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Horm Res Paediatr 2018 Dec 12:1-14. Epub 2018 Dec 12.

The hypothalamic-pituitary-thyroid axis is a common site of unintended, acquired disease either during or after the treatment of cancer. Children treated with external radiation therapy are at the highest risk for developing a thyroid-related late effect, but thyroid dysfunction and second primary thyroid neoplasms can also occur after treatment with radiopharmaceutical agents such as 131I-metaiodobenzylguanidine. Increasingly recognized is the development of early thyroid dysfunction as an off-target consequence of the more novel cancer therapeutics such as the tyrosine kinase inhibitors and immune checkpoint inhibitors. Read More

Ear Nose Throat J 2018 Dec;97(12):E7-E10

University of Arizona College of Medicine - Tucson, 1501 N. Campbell Ave., PO Box 245017, Tucson, AZ 85724, USA.

Cystic neck masses in the pediatric population are common but rarely concerning for malignancy. Given this typically benign nature, they are frequently managed conservatively. Here we present an unusual case of a waxing and waning cystic neck mass in a pediatric patient. Read More

PLoS One 2018 12;13(12):e0209225. Epub 2018 Dec 12.

[This corrects the article DOI: 10.1371/journal.pone. Read More

Aging (Albany NY) 2018 Dec 12. Epub 2018 Dec 12.

Department of General Surgery, First Hospital of Shanxi Medical University, Taiyua, Shanxi 030001, China.

Anaplastic thyroid carcinoma (ATC) responds for the majority of death of thyroid carcinoma and often causes chemotherapy resistance. We investigated the influence of circEIF6 (Hsa_circ_0060060) on the cisplatin-sensitivity in papillary thyroid carcinoma (PTC) and ATC cells, and explored its regulation to downstream molecules miR-144-3p and Transforming Growth Factor α (TGF-α). Differentially expressed circRNAs in PTC were analyzed using the GSE93522 data downloaded. Read More

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

A Tahrani, University of Birmingham, Institute of Metabolism and Systems Research, Birmingham, United Kingdom of Great Britain and Northern Ireland.

Obstructive sleep apnoea (OSA) is a common disorder that is associated with serious co-morbidities with a negative impact on quality of life, life expectancy and health costs. As OSA is related to obesity and is associated with sleep disruption, increased inflammation and oxidative stress, it is not surprising that OSA has an impact on the secretion of multiple hormones and is implicated in the development of many endocrine conditions. On the other hand, many endocrine conditions that can affect obesity and/or upper airways anatomy and stability have been implicated in the development or worsening of OSA. Read More

Orbit 2018 Dec 12:1-8. Epub 2018 Dec 12.

a Division of Orbit & Oculofacial Surgery, Department of Ophthalmology , National University Hospital , Singapore , Singapore.

Introduction: The mainstay of therapy for active inflammatory phase of thyroid eye disease (TED) is immunosuppression. Patients in our centre with early active TED are treated with pulsed intravenous methylprednisolone (IVMP). Two different protocols are offered in our centre: High dose (1g/day for 3 days, monthly for 6 months), or EUGOGO protocol (500 mg weekly for six weeks, followed by 250 mg weekly for the next 6 weeks). Read More

J Cancer Res Ther 2018 Dec;14(Supplement):S1201-S1208

Department of Medical Oncology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.

Aims: In this study, we investigated the expression of thyroid transcription factor-1 (TTF-1) in lung adenocarcinoma patients' samples and analyzed the association of TTF-1 with clinicopathological parameters, prognosis, and treatment options in patients with lung adenocarcinoma.

Subjects And Methods: This retrospective study enrolled 200 patients who were histologically confirmed lung adenocarcinoma with Stage I-IV disease, between 2008 and 2015 years. The cytological archive of these hospitals' Pathology Department was searched. Read More

J Cancer Res Ther 2018 Dec;14(Supplement):S1170-S1172

Department of Thyroid and Breast Surgery, Clinical Medical College of Yangzhou University, Subei People's Hospital of Jiangsu Province, Yangzhou 225001, Jiangsu, P.R. China.

Aim Of Study: Breast cancer invasion and metastasis is the main reason for the failure, and laminin is involved in it. This study intends to explore the expression of laminin in breast cancer and normal breast tissue and its clinical significance.

Materials And Methods: We use immunohistochemical assay for the detection of breast infiltrating ductal cancer tissues and normal breast tissues of laminin expression and discuss their role in breast cancer invasion and metastasis. Read More

J Cancer Res Ther 2018 Dec;14(Supplement):S969-S974

Department of Ultrasound, Linzi District People's Hospital, Zibo 255 400, Shandong Province, China.

Purpose: The incidence of papillary thyroid carcinoma (PTC) has dramatically increased over the past two decades. This study aimed to investigate the disparity of gene expression between PTC and normal tissues.

Materials And Methods: Gene chip data of E-GEOD-33630 and E-GEOD-60542 were acquired and downloaded from European Bioinformatics Institute Part of the European Molecular Biology Laboratory website. Read More

Curr Radiopharm 2018 Dec 11. Epub 2018 Dec 11.

Department of Nuclear Medicine, S. Andrea Hospital, La Spezia. Italy.

Objective: Neuroendocrine neoplasms (NENs) are generally defined as rare and heterogeneous tumors. The gastrointestinal system is the most frequent site of NENs localization, however they can be found in other anatomical regions, such as pancreas, lungs, ovaries, thyroid, pituitary, and adrenal glands. Neuroendocrine neoplasms have significant clinical manifestations depending on the production of active peptide. Read More

Diabetes Ther 2018 Dec 11. Epub 2018 Dec 11.

Medical University of South Carolina, Charleston, SC, USA.

Introduction: iGlarLixi is a titratable, fixed-ratio combination of insulin glargine (100 units/mL) and lixisenatide (33 μg/mL). This review evaluates the overall safety and adverse event (AE) profile of iGlarLixi in patients with type 2 diabetes.

Methods: We collated patient-level data from the phase 2 LixiLan proof-of-concept trial and the phase 3 LixiLan-L (insulin-experienced patients) and LixiLan-O (insulin-naïve patients) trials to evaluate AEs associated with iGlarLixi. Read More

Pathol Oncol Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Anesthesiology, The First People's Hospital of Jiangxia District Wuhan City, No. 1, Zhifang Culture Avenue, Jiangxia District, Wuhan, Hubei, 430200, People's Republic of China.

Thyroid cancer (TC) is the one of the most common endocrine malignancy. However, currently there are no specific and sensitive biomarkers for predicting the prognosis for TC. In this study, we for the first time showed MIR22HG was down-regulated in thyroid cancer by analyzing public datasets, including TCGA, GSE29265, GSE33630, and GSE55091. Read More

Pathol Oncol Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Pathology, the First People's Hospital of Jingmen, Jingmen, 448000, Hubei Province, China.

To observe the expression of P53, CyclinD1, Ki-67, Galectin-3, COX-2, Bcl-2 and approach their contribution on assessing the invasive potential for Hurthle cell tumors. Seventy-three cases of Hurthle cell tumor were collected for immunohistochemistry staining. The patients were followed up with 8 months to 5 years. Read More

Pathol Oncol Res 2018 Dec 11. Epub 2018 Dec 11.

Department of General Surgery, Department of Hepatopancreatobiliary Surgery, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Tongbai Road #195, Zhengzhou, 450007, Henan, China.

APTR has been employed as a potential biomarker attributing to it was involved in carcinogenesis and malignancy's progression. However, the roles of APTR in papillary thyroid cancer (PTC) and anaplastic thyroid cancer (ATC) are unclear. In the present study, we aimed to explore the relative expression of APTR in PTC and ATC tissues and the relation between APTR expression and PTC clinicopathological features. Read More

Biol Trace Elem Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, NO.34 North Zhongshan Road, Quanzhou City, Fujian Province, People's Republic of China.

Iodine is an important chemical for thyroid hormone synthesis. The association between iodine nutrition status and the risk of disease present U-shaped curve, as either low or high iodine nutrition status will increase the risk of thyroid diseases. Endoplasmic reticulum stress (ER stress), which can induce over expressions of inflammation factors, like monocyte chemo-attractant protein-1 (MCP-1), is related to the pathogenesis of thyroid disease. Read More

EJNMMI Phys 2018 Dec 12;5(1):32. Epub 2018 Dec 12.

Department of Nuclear Medicine, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.

Purpose: Radioiodine has been used for the treatment of benign thyroid diseases for over 70 years. However, internationally, there is no common standard for pretherapeutic dosimetry to optimally define the individual therapy activity. Here, we analyze how absorbed tissue doses are influenced by different approaches to pretherapeutic activity calculation of varying complexity. Read More

World J Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgery, KUMC Thyroid Center, Korea University Hospital, Korea University College of Medicine, 73, Inchon-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.

Background: Endoscopic transoral thyroidectomy is a recently introduced technique of remote access thyroidectomy. We previously reported the feasibility of the robotic approach (TORT). Nevertheless, experience to date is limited, with scant data on outcomes in patients with papillary thyroid carcinoma (PTC). Read More

Internist (Berl) 2018 Dec 11. Epub 2018 Dec 11.

Medizinische Klinik und Poliklinik I, Schwerpunkt Endokrinologie und Diabetologie, Universitätsklinikum Würzburg, Oberdürrbacher Str. 6, 97070, Würzburg, Deutschland.

Drugs Today (Barc) 2018 Nov;54(11):695-704

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Anaplastic thyroid cancer is a rare but extremely aggressive type of thyroid cancer. Treatment typically consists of surgery, external beam radiotherapy and cytotoxic chemotherapy. However, available literature suggests only modest survival benefit for cytotoxic chemotherapy. Read More

Biomed Res Int 2018 14;2018:7375169. Epub 2018 Nov 14.

Department of Emergency Surgery, The First Affiliated Hospital of Nanchang University, No. 17 Yongwai Street, Nanchang, Jiangxi Province 330006, China.

Introduction: Pretreatment platelet-to-lymphocyte ratio (PLR) has been considered a prognostic factor in various cancers. However, the application of PLR in the assessment of patients with cholangiocarcinoma remains controversial. This study aimed to evaluate the prognostic value of pretreatment PLR in cholangiocarcinoma. Read More

Biomed Res Int 2018 14;2018:2032413. Epub 2018 Nov 14.

Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China.

Ethnic differences in the level of thyroid hormones exist among individuals. The American Thyroid Association (ATA) recommends that an institution or region should establish a specific thyroid hormone reference value for each stage of pregnancy. To date, a limited number of studies have reported the level of thyroid hormones in Chinese minorities, and the exact relationship between BMI and thyroid function in pregnant women is ill. Read More

Case Rep Endocrinol 2018 12;2018:4369531. Epub 2018 Nov 12.

Department of Endocrinology, La Rabta hospital, Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia.

Thyroid involvement with tuberculosis is an uncommon condition even in endemic countries. As its clinical presentation is not specific, diagnosis is often difficult and requires histopathological confirmation. Herein we report an observation of secondary tuberculosis of the thyroid gland in a woman with a type 2 diabetes mellitus and a primary hypothyroidism. Read More

Nucl Med Mol Imaging 2018 Dec 27;52(6):475-478. Epub 2018 Oct 27.

3Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

We present the case of a 36-year-old woman who underwent F-FDG PET/CT with suspicion of a primary breast malignancy. However, PET/CT detected an occult renal cell carcinoma with metastases to the thyroid, breast, lungs and lymph nodes. Thyroid and breast metastases are atypical metastatic sites of renal cell carcinoma. Read More

Nucl Med Mol Imaging 2018 Dec 3;52(6):468-472. Epub 2018 Nov 3.

1Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 13620 South Korea.

Planar scintigraphy using Tc-99m pertechnetate is useful for snapshot evaluation of hot thyroid nodules, which are pathologically follicular adenoma and seldom, if ever, malignant. The autonomy of the hot nodules has been demonstrated by the presence of thyroid-stimulating hormone-dependent extra-nodular thyroid tissue besides the hot nodules. Here, we present two cases of hot thyroid nodules in patients who underwent quantitative single-photon emission computed tomography/computed tomography (SPECT/CT). Read More

Int J Endocrinol 2018 14;2018:1871530. Epub 2018 Nov 14.

Department of endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Purpose: To determine if the TSH is related to estimated glomerular filtration rate (eGFR) in T2D patients without overt thyroid dysfunction.

Methods: A cohort study of 5936 T2D patients was assessed for thyroid and kidney functions, in whom 248 with subclinical hyperthyroidism and 362 with subclinical hypothyroidism. Serum creatinine and 24-hour urine albumin excretion (UAE) were collected. Read More

Cancer Manag Res 2018 22;10:6181-6193. Epub 2018 Nov 22.

Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang 110001, China,

Background: The incidence of papillary thyroid cancer (PTC) is increasing faster than any other solid tumors worldwide. Invasion and metastasis are the main reasons for the poor prognosis of patients with PTC. Previously, we observed significantly low expression of miRNA-299-5p in invasive PTC tissue samples. Read More

Clin Interv Aging 2018 22;13:2407-2419. Epub 2018 Nov 22.

Department of Geriatrics, The First Hospital of Jilin University, Changchun 130021, Jilin, China,

Purpose: The aim of this study was to explore the role of miRNAs in the process of skeletal muscle aging.

Materials And Methods: We analyzed the miRNA microarray datasets from 19 young and 17 old skeletal muscle samples by bioinformatic analysis. Differentially expressed miRNAs were identified, followed by function and pathway enrichment analysis. Read More

Indian J Surg Oncol 2018 Dec 18;9(4):592-594. Epub 2018 May 18.

3Department of Pathology, St. John's Medical College and Hospital, Bengaluru, Karnataka India.

Multiple primary cancer (MPC) has an incidence of 1.8% and is defined as having two or more cancers in a single patient. Synchronous tumors are defined as ≥ 2 primary tumors occurring within 6 months of diagnosis of the first primary tumor. Read More

Indian J Surg Oncol 2018 Dec 19;9(4):477-482. Epub 2018 May 19.

Department of Head-Neck and Thoracic Surgical Oncology, Fortis Memorial Research Institute (FMRI), Gurugram, Sector-44, Gurugram, Haryana 122002 India.

The aim of this observational prospective study was to determine the technical feasibility, safety, and adequacy of robotic hemithyroidectomy. From April 2015 to May 2016, 16 patients with solitary thyroid lesion underwent robotic hemithyroidectomy using the Surgical system. Patients were observed and data were recorded on surgical time, blood loss, complications, and functional outcome of the patients. Read More

Eye (Lond) 2018 Dec 11. Epub 2018 Dec 11.

Department of Ophthalmology, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, UK.

Imaging in thyroid eye disease (TED) is used to exclude other diagnoses, assess for apical crowding and plan surgery. But to quantify TED activity objectively, subjective clinical scoring assessments remain the norm. Magnetic resonance imaging (MRI) T2-relaxation times correlate with extra-ocular muscle (EOM) inflammation, but are confounded by signal from fat. Read More

Pediatr Hematol Oncol 2018 Dec 11:1-10. Epub 2018 Dec 11.

b Texas Children's Cancer and Hematology Centers , Houston , Texas , USA.

Background: Craniospinal irradiation (CSI) often results in endocrine deficiencies in children with medulloblastoma due to irradiation of the hypothalamic-pituitary axis (HPA) or the thyroid gland. CSI with Proton radiation therapy (PRT) has the potential to decrease the risk of hypothyroidism by reduction in radiation dose to these organs. This study compares the risk for hypothyroidism in patients with medulloblastoma treated with Photon radiation therapy (XRT) or PRT. Read More

J Cardiol Cases 2013 Apr 1;7(4):e93-e96. Epub 2012 Dec 1.

Department of Cardiology, Bayindir Hospital, Ankara, Turkey.

Multiple endocrine neoplasia 2 (MEN 2) is a hereditary syndrome associated with medullary thyroid carcinoma, pheochromocytoma (PCC), and hyperparathyroidism. PCCs in patients with MEN 2 are usually found in the adrenals after the manifestation of medullary thyroid cancer and are commonly bilateral and hormonally active. Unfortunately, a diagnosis of MEN 2 or PCC often is delayed until after the patient has developed an advanced MEN 2-related tumor. Read More

J Cardiol Cases 2010 Dec 6;2(3):e147-e150. Epub 2010 Jul 6.

National Cardiovascular Center, Osaka, Japan.

We encountered a case of hypothyroidism showing Brugada-type electrocardiogram (ECG). A 52-year-old man was referred to our hospital in August 2009. Past medical history showed that liver dysfunction and face edema of unknown origin had been pointed out 1 year earlier. Read More

Cell Physiol Biochem 2018 11;51(5):2434-2444. Epub 2018 Dec 11.

The Clinical Medical Testing Laboratory, Northern Jiangsu People's Hospital and Clinical Medical College of Yangzhou University, Yangzhou, China.

Background/aims: Glycolysis, a multi-step enzymatic reaction, is considered to be the root of cancer development and progression. The aim of this study is to figure out which glycolysis enzyme participates in the progression of breast cancer and its possible mechanisms.

Materials: We firstly screened out PGK1 by performing an RT-PCR array of glycolysis-related genes in three paired breast cancer samples, and further investigated PGK1 using TCGA and our own database. Read More

Acta Paediatr 2018 Dec 7. Epub 2018 Dec 7.

Department of Neonatology, University Hospitals Leuven, KU, Leuven, Belgium.

Aim: Thyroid hormones are crucial for fetal and neonatal brain development. This paper provides an overview of the normal role of thyroid hormones in fetal brain development and the pathophysiology of transient hypothyroxinaemia of prematurity (THOP). It also discusses the diagnostic and therapeutic controversies around THOP and looks at directions for future research. Read More

Pathol Int 2018 Dec 7. Epub 2018 Dec 7.

Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Surgery, Ewha Womans University Medical Center, Seoul, South Korea.

Background: The effect of Graves' disease on the risk of postoperative complications in patients undergoing total thyroidectomy is unclear.

Methods: The incidence of recurrent laryngeal nerve (RLN) injury and hypoparathyroidism were analyzed between 165 patients with Graves' disease (GD group) and 1:1 matched patients with euthyroid states (control group).

Results: The matched cohorts did not differ in age, sex, body mass index, pathologic diagnosis, and extent of operation. Read More

Head Neck 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.

Background: This study assessed the feasibility of near-infrared fluorescence imaging with indocyanine green (ICG) to identify the parathyroid glands (PGs) intraoperatively and to assess their perfusion after thyroid resection.

Methods: Patients undergoing elective thyroidectomy were enrolled in this prospective study. An intravenous bolus of 7. Read More

Head Neck 2018 Dec 9. Epub 2018 Dec 9.

Department of Medicine and Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, New York.

Background: We evaluated the usefulness of three-dimensional (3D) ultrasound of cervical lymph nodes (LN), when two-dimensional (2D) ultrasound evaluation is not sufficient to clearly evaluate lymph node characteristics, in thyroid cancer patients being followed after thyroidectomy.

Methods: Two readers retrospectively analyzed 2D and 3D images of 147 LNs; LNs were categorized as normal, reactive, suspicious, or indeterminate, and confidence level was rated. Results were compared to cytological/clinical data. Read More

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Thyroid and Endocrine Surgery Section, Department of Surgery, Gachon University College of Medicine, Gil Medical Center, Incheon, Republic of Korea.

Background: Papillary thyroid microcarcinomas (PTMCs) often demonstrate lateral lymph node (LN) metastasis. The purpose of this study was to assess whether the size of primary tumor should be considered in deciding lateral neck dissection extent.

Methods: We conducted a retrospective comparison of patients with PTMC and papillary thyroid carcinoma (PTC) larger than 1 cm who received lateral LN dissection from 2009 to 2015. Read More

Head Neck 2018 Dec 9. Epub 2018 Dec 9.

Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana.

Background: Fine-needle aspiration (FNA) cytology has been the standard of care in the workup of cervical lymph nodes (LNs) in patients with recurrent papillary thyroid cancer (PTC) and suspicious cervical LNs. Recently, FNA thyroglobulin (TG) washout measurement has been proposed as an adjunct in the management of these patients. We hypothesize that using FNA-TG washout for suspicious cervical LNs would increase the accuracy of diagnosing metastatic disease especially in cystic and highly vascular cervical LN in patients with recurrent PTC. Read More

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Department of Surgery, Thyroid Cancer Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background: Recent guidelines advocate unilateral thyroidectomy for low-risk 1-cm to 4-cm differentiated thyroid cancer (DTC). This study was designed to examine the association between the extent of thyroidectomy and oncologic outcomes in patients with 1-cm to 4-cm DTC.

Materials And Methods: From April 1978 to December 2011, 16 057 patients with DTC underwent thyroidectomy at Yonsei University Hospital. Read More

Laryngoscope 2018 Dec 11. Epub 2018 Dec 11.

Radiation and Public Health Project, Ocean City, New Jersey, U.S.A.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):8042-8059

Gynecological Oncology, National Cancer Institute, Aviano, Italy.

Objective: Infertile women requiring ovarian stimulation and assisted reproduction techniques (ART) are faced with difficult issues. The fear that using hormones could increase their risk of cancer is the most significant. One of the main challenges for assessing cancer risk after ART is the difficulty to separate it from the underlying condition of infertility per se. Read More

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7778-7787

Department of Oncology, The First People's Hospital of Yunnan Province, Kunming, China.

Objective: We investigated the relationship between Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC) in children and adolescents.

Patients And Methods: We carried out a retrospective study of thyroidectomies performed from 2004 to 2017 at The First People's Hospital and the Tumor Hospital of Yunnan Province (Kunming, China). The occurrence and features of PTC and benign thyroid disease (BTD) in children and adolescents (age ≤ 20 years) were compared. Read More

World J Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of Ultrasound, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, 197 Ruijin 2 Rd, 200025, Shanghai, China.

Background: Our purpose is to assess the effectiveness and safety of ultrasound-guided percutaneous microwave ablation (MWA) for lymph node metastases (LNMs) from papillary thyroid carcinomas (PTC).

Methods: In total, 14 patients with recurrent PTC were enrolled in this retrospective study. The vascularity within the ablation zone was evaluated by contrast-enhanced ultrasonography (CEUS) after MWA. Read More

World J Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of General Surgery, Monash University Endocrine Surgery Unit, The Alfred Hospital, 55 Commercial Rd, Melbourne, VIC, 3004, Australia.

Background: Since the mid-1800s, thyroidectomy has transformed from a procedure associated with high to near-zero mortality. Nonetheless, surgeons must continue to strive to improve patient care. Using historical records and contemporary data, this study compares the practice and outcomes of thyroid surgery at a tertiary institution during two periods, 50 years apart. Read More

Eur Arch Otorhinolaryngol 2018 Dec 10. Epub 2018 Dec 10.

Otorhinolaryngology-Head and Neck Surgery Department, University Hospital of Modena, Largo del Pozzo, 71, 41125, Modena, Italy.

Purpose: Locoregional recurrence of thyroid carcinoma is relatively common and reported rate are between 5 and 20%. Cervical nodes are usually involved, especially at the central compartment. The management of recurrent thyroid carcinoma at central compartment still remains challenging because of higher incidence of complication rate. Read More

Genes Genomics 2018 Dec 8. Epub 2018 Dec 8.

Department of Informatics, University of Evora, 7004-516, Evora, Portugal.

Background: Identification of differentially expressed genes, i.e., genes whose transcript abundance level differs across different biological or physiological conditions, was indeed a challenging task. Read More

Eur J Nutr 2018 Dec 10. Epub 2018 Dec 10.

International Agency for Research on Cancer (IARC), Lyon, France.

Purpose: Coffee and tea constituents have shown several anti-carcinogenic activities in cellular and animal studies, including against thyroid cancer (TC). However, epidemiological evidence is still limited and inconsistent. Therefore, we aimed to investigate this association in a large prospective study. Read More