Search Our Scientific Publications & Authors

AACE Clin Case Rep 2022 May-Jun;8(3):131-134. Epub 2022 Jan 13.

Division of General Surgery, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.

Objective: Distant metastases from papillary thyroid carcinoma (PTC) are relatively rare and may be associated with a poor prognosis. The adrenal gland is a highly unusual site of metastasis in the natural course of PTC. Herein, we describe a case of an incidentally detected metastatic solid variant of PTC in the adrenal gland of an asymptomatic patient as the initial presentation. Read More

Cytojournal 2022 4;19. Epub 2022 Feb 4.

Department of Pathology, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India.

Endocr Connect 2022 01 27;11(1). Epub 2022 Jan 27.

Department of Internal Medicine, Rijnstate Hospital, Arnhem, the Netherlands.

Objective: Radiofrequency ablation (RFA) is increasingly considered the prime option for treating symptomatic, benign, non-functioning thyroid nodules (NFTN). However, little is known about the degree of operator experience required to achieve optimal results. This study describes the RFA learning curve of a single-center team. Read More

Cureus 2021 Oct 9;13(10):e18618. Epub 2021 Oct 9.

Dermatology, University of California, Davis Medical Center, Sacramento, USA.

Solitary cutaneous focal mucinosis is a unique condition defined by the presence of mucin, a hyaluronic acid complex, in the dermis. The lesion typically presents as an isolated, asymptomatic papule or nodule on the extremities or back and is not associated with any systemic condition. Conversely, multiple cutaneous focal mucinosis present with numerous skin lesions has been found to be associated with systemic diseases such as scleromyxedema, systemic lupus erythematous, and thyroid disease. Read More

Ultrasound Med Biol 2022 02 12;48(2):209-216. Epub 2021 Nov 12.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical School of Usak University, Usak, Turkey.

Alterations in neck anatomy after thyroid surgery and post-operative fibrosis may be misleading by causing sonoelastographic changes in recurrent tissues in patients with recurrent nodular goiter and so may result in unnecessary biopsies or surgical procedures. Here, the aim was to examine thyroid sonoelastography values in patients developing a recurrence and presenting with recurrent nodular goiter with benign cytology after total or near-total thyroidectomy (T/N-TT). Twenty-nine nodules from 22 patients with a recurrence after T/N-TT whose biopsies were found to be benign constituted the patients, and 23 nodules from 23 participants among the non-operated patients having solitary or multiple thyroid nodules and with age, gender and body mass index values similar to those of the patients constituted our controls. Read More

Surg Clin North Am 2021 Dec;101(6):1081-1096

Department of Surgery, Division of Surgical Oncology, University of Nebraska Medical Center, 986880 Nebraska Medical Center, Omaha, NE 68198-6880, USA. Electronic address:

Incidental findings are common in the evaluation of surgical patients. Understanding the appropriate assessment and management of these frequent occurrences is important for the provision of comprehensive quality care. This review details the epidemiology, considerations, and recommendations for management of common incidental manifestations in surgical patients, including Meckel diverticulum, adrenal incidentaloma, thyroid nodule, solitary pulmonary nodule, small bowel intussusception, gallstones, and incidental appendectomy. Read More

Eur J Radiol 2021 Oct 14;143:109912. Epub 2021 Aug 14.

Department of Radiology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, China. Electronic address:

Purpose: This study aims to compare the diagnostic performance of two imaging methods for thyroid nodules ≤1.0 cm and reduce unnecessary overdiagnosis.

Methods: A retrospective study was conducted on 80 patients with pathologically confirmed solitary thyroid micronodules underwent both high-resolution ultrasound (HRUS) and High b-value (2000 s/mm) diffusion weighted imaging (DWI). Read More

AACE Clin Case Rep 2021 May-Jun;7(3):164-168. Epub 2021 Jan 7.

American Hospital of Paris, Thyroid Unit, Neuilly-sur-Seine, France.

Objective: Horner's syndrome (HS) is a rare complication of high-intensity focused ultrasound (HIFU) and radiofrequency ablation for thyroid nodules. We present such a case and discuss how to avoid this complication in the future.

Methods: This case occurred during HIFU treatment of a benign thyroid nodule (BTN). Read More

Medicine (Baltimore) 2021 May;100(21):e26165

Clinical Laboratories.

Abstract: Serum insulin-like growth factor 1 (IGF-1) is elevated in different cancers. However, relationships between serum IGF-1 and thyroid cancer (TC) are scarce. The present study aimed to investigate the clinical significance of serum IGF-1 in TC. Read More

Int J Surg Case Rep 2021 Apr 22;81:105804. Epub 2021 Mar 22.

Department of Surgery, Kangwon National University Hospital, Kangwon National University Hospital, 156, Baengnyeong-ro, Chuncheon-Si, Gangwon-Do 24289, Republic of Korea. Electronic address:

Introduction And Importance: Thyroid metastasis of colorectal cancer is rare and the patient with thyroid metastasis has no symptoms early in the disease course. On the other hand, evaluation of thyroid is not generally included in the routine follow-up of colorectal cancer. Therefore, the diagnosis of thyroid metastasis of colorectal cancer may be delayed. Read More

J Cytol 2020 Oct-Dec;37(4):193-199. Epub 2020 Sep 16.

Department of Endocrinology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.

Background: The incidence of thyroid cancer has been increasing worldwide. Thyroid imaging reporting and data system (TIRADS) has been proposed for risk stratification of thyroid nodules to improve categorical management. Fine needle aspiration cytology based on Bethesda system for reporting of thyroid cytopathology (BSRTC) plays a fundamental role in the evaluation of thyroid nodule microscopically. Read More

Front Oncol 2021 3;11:609075. Epub 2021 Mar 3.

Department of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Cervical lymph node metastasis (LNM) was found to be clinically significant prognostic factors of patients with papillary thyroid carcinomas (PTC). Ultrasound (US) characteristics of thyroid nodules and thyroid parenchyma may be used to predict LNM. To investigate the value of nodular US features as well as thyroid parenchymal microcalcifications on US in predicting LNM in patients with PTC. Read More

Eur J Endocrinol 2021 May;184(5):657-665

Thyroid Center, Brigham and Women's Hospital.

Objective: Surgical resection is recommended for cytologically indeterminate pediatric thyroid nodules due to their intermediate malignancy risk. We evaluated the utility of ultrasound characteristics for refining malignancy risk to inform the management of these nodules.

Design: Retrospective cohort study (2004-2019). Read More

Endocr Pract 2020 Jul 24;26(7):754-760. Epub 2020 Nov 24.

Johns Hopkins University School of Medicine, Division of Endocrinology, Diabetes and Metabolism, Baltimore, Maryland. Electronic address:

Objective: Clinical practice for differentiated thyroid cancer is moving towards lobectomy rather than total thyroidectomy in patients at low risk of recurrence. However, recurrence risk assessment depends on post-operative findings, while the surgical decision is based on preoperative factors. We determined the preoperative predictors of occult higher-risk pathology and rates of completion thyroidectomy among surgical candidates with nonbenign thyroid nodules 10 to 40 mm and no evidence of extrathyroidal extension or metastasis on preoperative evaluation. Read More

Indian J Endocrinol Metab 2020 Jul-Aug;24(4):349-354. Epub 2020 Aug 27.

Department of Endocrinology and R.G. KAR Medical College, Kolkata, West Bengal, India.

Background: High resolution ultrasonography (USG) is the first-line investigation in evaluation of euthyroid nodules. Thyroid imaging reporting and data system (TIRADS) is an USG-based risk stratification system for classifying thyroid nodules. Subjects with high-risk category of TIRADS undergo fine needle aspiration cytology (FNAC) and FNAC findings are reported according to Bethesda classification. Read More

J Am Soc Cytopathol 2021 Mar-Apr;10(2):164-167. Epub 2020 Jul 30.

Ascension St. John Hospital, Detroit, Michigan.

Introduction: Thyroid fine-needle aspiration (tFNA) is a powerful screening tool for assessing solitary thyroid nodules. Generally, morphologic evaluation of smears yields an accurate diagnosis; but, in some cases it is useful to have a cell block (CB) to conduct ancillary studies such as immunohistochemistry (IHC). Cytologic diagnoses guide clinical decisions, so it is important that accurate and efficient diagnoses be rendered. Read More

Dtsch Med Wochenschr 2020 08 7;145(17):1227-1235. Epub 2020 Jul 7.

In Germany and in other regions with former iodine deficiency, thyroid nodules and nodular goiter are still much more frequent than in the U.S.A. Read More

Case Rep Endocrinol 2020 31;2020:2128093. Epub 2020 Mar 31.

Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Sección XVI, Tlalpan, México City 14000, Mexico.

Synchronous parathyroid and papillary thyroid carcinoma are extremely rare. To our knowledge, only 15 cases have been reported in the last four decades. We describe a 50-year-old female without significant past medical or family history and no previous trauma presented with left heel pain that prompted her to seek medical attention. Read More

J Pak Med Assoc 2019 Aug;69(Suppl 3)(8):S45-S49

Department of Surgery, Al-Mustansiriya University, Baghdad, Iraq.

Objective: To define the value of clinical, imaging and histopathological investigations in the evaluation of solitary thyroid nodule, and to predict malignant risk or any abnormal functional activity.

Methods: The prospective study was conducted at AlYarmouk Teaching Hospital, Baghdad, Iraq, from March 2016 to March 2018, and comprised patients with thyroid nodule who underwent thyroidectomy. The patients were evaluated by history, clinical examination, thyroid isotope scan, thyroid ultrasonography, and fine needle aspiration cytology, and the results were correlated with post-operative histopathological examination. Read More

Acta Inform Med 2019 Jun;27(2):114-118

General/Family Medical Services, Public Healthcare Institution, Medical Centre Tuzla, Tuzla, Bosnia and Herzegovina.

Introduction: Pathology of thyroid nodules is present in all ages and it is frequently encountered in clinical practice. Thyroid nodules do not represent a single disease, but they are the clinical manifestation of a wide range of different thyroid diseases.

Aim: The objective of this study is to evaluate the frequency and localization of malignancy in solitary scintigraphic cold nodules, as well as the sensitivity, specificity and diagnostic accuracy of FNAB in comparison with histopathological findings. Read More

Pak J Med Sci 2019 Jul-Aug;35(4):1003-1007

Dr. Muhammad Ayoob Jat, Assistant Professor Surgery, Department of Surgery, College of Medicine, Northern Border University, Arar, KSA.

Objective: To assess the Solitary thyroid nodules by surgeon- performed ultrasound-guided FNAC and evaluate with the histopathological findings.

Methods: This study includes 100 Consecutive patients of a solitary thyroid nodule which were presented to the Outpatients Department of Surgery during the period of two years from September 2016 to August 2018. Exclusion criteria were patients with extra-thyroid swelling, diffuse goiter and multinodular goiter. Read More

Endocr Connect 2019 Aug;8(8):1195-1205

Department of Clinical Medicine, Health, Aarhus University, Aarhus N, Denmark.

Thyroid nodular disease is common, but predicting the risk of malignancy can be difficult. In this prospective study, we aimed to assess the diagnostic accuracy of shear wave elastography (SWE) in predicting thyroid malignancy. Patients with thyroid nodules were enrolled from a surgical tertiary unit. Read More

Hormones (Athens) 2019 Sep 28;18(3):321-324. Epub 2019 May 28.

Department of Nuclear Medicine and Thyroid Centre, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.

Introduction: Over the last few years, several scientific societies have introduced specific evaluation systems to stratify the risk of malignancy of thyroid nodules. Most of these classifications have been created on the basis of ultrasonographic features of the commonest thyroid carcinoma histotype. Herein, we report a case of anaplastic thyroid carcinoma presenting at ultrasound (US) examination as an unsuspicious thyroid nodule associated with distant metastases, which was followed by the patient's death a short time later. Read More

Mymensingh Med J 2019 Apr;28(2):356-363

Dr Md Abdul Momin, Assistant Professor, Department of Surgery, Mainamoti Medical College, Cumilla, Bangladesh; E-mail:

Discrete swelling in one lobe of thyroid gland with no palpable abnormality elsewhere is termed as a solitary thyroid nodule. FNAC is the investigation of choice in solitary nodule for selection of surgical cases due to compliance, simple and quick to perform. The aim of this study was to evaluate the utility of FNAC in solitary thyroid nodule with the relation of histopathological findings. Read More

Ann Med Surg (Lond) 2019 May 13;41:43-46. Epub 2019 Apr 13.

Department of Endocrine Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareily Road, Lucknow, 226 014, India.

Introduction: In the modern day busy clinical practice, the communication between patient/relative and caregiver is at a minimal level. The patients and relatives feel apprehensive when advised about surgical/interventional treatment. Storytelling is such a technique of health communication made in common man language and can operate in a virtual environment. Read More

J Endocr Soc 2019 Apr 5;3(4):791-800. Epub 2019 Mar 5.

Thyroid Interdisciplinary Team, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Context: The impact of Hashimoto thyroiditis (HT) on the risk of thyroid cancer and its accurate detection remains unclear. The presence of a chronic lymphocytic infiltration imparts a logical mechanism potentially altering neoplastic transformation, while also influencing the accuracy of diagnostic evaluation.

Methods: We performed a prospective, cohort analysis of 9851 consecutive patients with 21,397 nodules ≥1 cm who underwent nodule evaluation between 1995 and 2017. Read More

Indian J Surg Oncol 2018 Dec 19;9(4):477-482. Epub 2018 May 19.

Department of Head-Neck and Thoracic Surgical Oncology, Fortis Memorial Research Institute (FMRI), Gurugram, Sector-44, Gurugram, Haryana 122002 India.

The aim of this observational prospective study was to determine the technical feasibility, safety, and adequacy of robotic hemithyroidectomy. From April 2015 to May 2016, 16 patients with solitary thyroid lesion underwent robotic hemithyroidectomy using the Surgical system. Patients were observed and data were recorded on surgical time, blood loss, complications, and functional outcome of the patients. Read More

Head Neck 2018 08 6;40(8):1812-1823. Epub 2018 Apr 6.

Department of Head and Neck-Endocrine Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

Background: The impact of oncogene panel results on the surgical management of indeterminate thyroid nodules (ITNs) is currently unknown.

Methods: Surgical management of 649 patients consecutively evaluated from October 2008 to April 2016 with a single nodule biopsied and indeterminate cytology (193 evaluated with and 456 without oncogene panels) was assessed and compared. Histological features of 629 consecutively resected ITNs (164 evaluated with and 465 without oncogene panels) were also characterized and compared. Read More

J Endocrinol Invest 2018 Jul 14;41(7):809-813. Epub 2017 Dec 14.

Department of Surgical Pathology, The University of Pisa, 56124, Pisa, Italy.

Purpose: To report the clinical implications of an initial experience with transoral endoscopic thyroidectomy vestibular approach (TOETVA).

Methods: From March to November 2017, five cases of TOETVA were performed. Data reported include patient demographics, indication for surgery, extent of surgery, operative time, the need to convert to cervicotomy, the length of hospital stay and post-operative pain and morbidity. Read More

Clin Nucl Med 2018 Jan;43(1):e27-e28

From the Nuclear Medicine Service, James A. Haley Veterans' Hospital & Clinics; and University of South Florida Morsani College of Medicine, Tampa, FL.

I-NaI thyroid uptake and scan in a 46-year-old woman with symptomatic hyperthyroidism demonstrated marked, diffusely increased uptake consistent with Graves disease, as well as a solitary hypofunctioning ("cold") nodule. Pathologic evaluation following total thyroidectomy and selective neck dissection revealed invasive multifocal papillary thyroid carcinoma in a background of Graves disease and 5 of 36 lymph nodes positive for metastatic disease. This case serves as a reminder that when present a cold nodule in the setting of Graves disease warrants further evaluation for underlying malignancy. Read More