160,207 results match your criteria Thyroid Disease


Long-term thyroid disorders in pediatric survivors of hematopoietic stem cell transplantation after chemotherapy-only conditioning.

J Pediatr Endocrinol Metab 2018 Jun 23. Epub 2018 Jun 23.

Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

Background: Thyroid dysfunction (TD) was usually described in hematopoietic stem cell transplantation (HSCT) recipients who were given total body irradiation (TBI) in the conditioning regimen. Because previous studies have reported discrepant results regarding the presence of long-term thyroid complications in HSCT survivors following chemotherapy-only conditioning, we investigated the frequency of thyroid abnormalities in a series of children treated with HSCT for different disorders without TBI as part of the conditioning protocol.

Methods: We compared thyroid-stimulating hormone, free thyroxine, total triiodothyronine (TT3), anti-peroxidase (TPO Ab) and anti-thyroglobulin antibodies and thyroid volume z-score in 28 HSCT survivors and 16 healthy subjects matched for age and sex. Read More

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Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.

Curr Treat Options Oncol 2018 Jun 21;19(8):38. Epub 2018 Jun 21.

Alpert Medical School of Brown University, Rhode Island Hospital, 593 Eddy St., Providence, RI, 02903, USA.

Opinion Statement: Diffuse large B cell lymphoma (DLBCL) arises from extranodal organs in about 30% of cases. Its prognosis and risk of recurrence in the central nervous system (CNS) vary according to the primary site of origin. Recent studies begin to clarify these differences using molecular classification. Read More

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June 2018
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How much of the predisposition to Hashimoto's thyroiditis can be explained based on previously reported associations?

J Endocrinol Invest 2018 Jun 21. Epub 2018 Jun 21.

Department of Endocrinology, Medical Faculty, Jagiellonian University Medical College, Krakow, Poland.

Purpose: Our insight in the genetics of Hashimoto's thyroiditis (HT) has become clearer through information provided by genome-wide association studies and candidate gene studies, but remains still not fully understood. Our aim was to assess how many different genetic risk variants contribute to the development of HT.

Methods: 147 HT cases (10. Read More

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June 2018
1 Read

Role of Tumor-Derived Chemokines in Osteolytic Bone Metastasis.

Front Endocrinol (Lausanne) 2018 7;9:313. Epub 2018 Jun 7.

New Jersey Center for Science, Technology and Mathematics, Kean University, Union, NJ, United States.

Metastasis is the primary cause of mortality and morbidity in cancer patients. The bone marrow is a common destination for many malignant cancers, including breast carcinoma (BC), prostate carcinoma, multiple myeloma, lung carcinoma, uterine cancer, thyroid cancer, bladder cancer, and neuroblastoma. The molecular mechanism by which metastatic cancer are able to recognize, infiltrate, and colonize bone are still unclear. Read More

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Anterior hypopituitarism in a patient with amyloidosis secondary to Crohn's disease: a case report.

J Med Case Rep 2018 Jun 22;12(1):174. Epub 2018 Jun 22.

Department of Endocrinology and Nutrition, Cliniques Universitaires Saint Luc, UCL, Avenue Hippocrate 10, 1200, Woluwé-Saint-Lambert, Belgium.

Background: Amyloid infiltration of endocrine glands has been reported, mostly in the thyroid, pancreas, adrenals, and testes, but affected patients do not frequently exhibit overt endocrine insufficiency. Here we report the case of a patient with complete anterior hypopituitarism probably due to a known systemic amyloidosis.

Case Presentation: Our male Caucasian patient was diagnosed with Crohn's disease at the age of 22 years. Read More

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June 2018
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Higher levels of thyroxine may predict a favorable response to donepezil treatment in patients with Alzheimer disease: a prospective, case-control study.

BMC Neurosci 2018 Jun 22;19(1):36. Epub 2018 Jun 22.

Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, No. 130, Kai-Syuan, 2nd Road, Ling-Ya District, Kaohsiung, 802, Taiwan.

Background: Cholinergic hypothesis has been advanced as an etiology of Alzheimer disease (AD) on the basis of the presynaptic deficit found in the diseased brains, and cholinesterase inhibitors (ChEIs) are the treatment of choice for these patients. However, only about half of treatment efficacy was found. Because increasing evidence supports an extensive interrelationship between thyroid hormones (THs), cortisol level and the cholinergic system, the aim of the present study was to evaluate thyroid function and cortisol level in patients with mild to moderate AD before and after ChEIs treatment, and to identify possible variations in response. Read More

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June 2018
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Predictors of Neck Reoperation and Mortality after Initial Total Thyroidectomy for Differentiated Thyroid Cancer.

Thyroid 2018 Jun 21. Epub 2018 Jun 21.

University of California Davis, Otolaryngology, Sacramento, California, United States ;

Background: In an era of rising differentiated thyroid cancer incidence, the rate and impact of neck reoperation may inform the intensity of earlier interventions and surveillance. In this study, we sought to define predictors of neck reoperation and to assess its impact on survival.

Methods: Using California Cancer Registry linked to California Office of Statewide Health Planning and Development records, we performed a retrospective cohort study of 24,230 patients with total or near total thyroidectomy for papillary or follicular thyroid cancer during 1991-2008 and follow up through 2013. Read More

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June 2018
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Antitumor Perspectives of Oleuropein and Its Metabolite Hydroxytyrosol: Recent Updates.

J Food Sci 2018 Jun 21. Epub 2018 Jun 21.

Inst. of Food and Nutritional Sciences, PMAS-Arid Agriculture Univ., Rawalpindi, Pakistan.

Olive fruit is a significant and promising source of potential bioactive compounds such as oleuropein and hydroxytyrosol. Oleuropein is the ester of elenolic acid and 3,4-dihydroxyphenyl ethanol (HT). It is the main glycoside in olives, the degradation of which results in the formation of hydroxytyrosol in olive oil. Read More

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Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage.

Oncotarget 2018 Jun 1;9(42):26670-26678. Epub 2018 Jun 1.

Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.

We investigated the possible association between the lymph node density and survival outcomes in differentiated papillary thyroid carcinoma, and examined whether the lymph node density was a predictor in a multivariate analysis adjusted for the pathological stage in the eighth edition of the Union for International Cancer Control Tumor-Node Metastasis Classification of Malignant Tumors. A total of 543 patients with papillary thyroid carcinoma were enrolled. We performed restaging according to the eighth edition. Read More

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June 2018
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Gestational Hypothyroxinemia Affects Its Offspring With a Reduced Suppressive Capacity Impairing the Outcome of the Experimental Autoimmune Encephalomyelitis.

Front Immunol 2018 6;9:1257. Epub 2018 Jun 6.

Departamento de Ciencias Biológicas, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile.

Hypothyroxinemia (Hpx) is a thyroid hormone deficiency (THD) condition highly frequent during pregnancy, which although asymptomatic for the mother, it can impair the cognitive function of the offspring. Previous studies have shown that maternal hypothyroidism increases the severity of experimental autoimmune encephalomyelitis (EAE), an autoimmune disease model for multiple sclerosis (MS). Here, we analyzed the immune response after EAE induction in the adult offspring gestated in Hpx. Read More

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June 2018
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Prolactin-Producing Pituitary Carcinoma, Hypopituitarism, and Graves' Disease-Report of a Challenging Case and Literature Review.

Front Endocrinol (Lausanne) 2018 6;9:312. Epub 2018 Jun 6.

Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar São João, Porto, Portugal.

Introduction: The diagnosis of pituitary carcinoma is very rare, requires the evidence of metastatic disease, and has a poor overall survival. Malignant prolactinoma frequently requires dopamine agonist therapy, pituitary surgery, radiotherapy, and even chemotherapy.

Case Description: A 19-year-old female presented with galactorrhea, primary amenorrhea, and left hemianopsia. Read More

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June 2018
1 Read

Extraocular Muscle Enlargement and Thyroid Eye Disease-like Orbital Inflammation Associated with Immune Checkpoint Inhibitor Therapy in Cancer Patients.

Ophthalmic Plast Reconstr Surg 2018 Jun 19. Epub 2018 Jun 19.

Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery.

Purpose: To describe thyroid eye disease (TED)-like orbital inflammatory syndrome in 3 cancer patients treated with immune checkpoint inhibitors.

Methods: All consecutive patients treated by the senior author who were receiving immune checkpoint inhibitors and developed TED-like orbital inflammation were included.

Results: Three cancer patients treated with immune checkpoint inhibitors developed orbital inflammation. Read More

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[Pituitary lactotroph adenomas resistant to dopamine agonist treatment: histological and immunohistochemical characteristics].

Arkh Patol 2018 ;80(3):34-39

National Medical Research Center of Endocrinology, Ministry of Health of Russia, Moscow, Russia.

Objective: To present the histological and immunohistochemical characteristics of pituitary lactotroph adenomas (PLAs) resistant to dopamine agonist treatment.

Subject And Methods: The investigators examined paraffin-embedded blocks and histological sections obtained from 19 patients (13 women, 6 men), whose median age was 29 (19, 38) years, after surgical treatment (adenomectomy) for PLAs resistant to dopamine agonist treatment. Immunohistological examination was performed using antibodies against prolactin (PRL), growth hormone (GH), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), type 2 dopamine receptors (DR), estrogen receptors-α (ERα), the proliferation marker Ki-67, and the endothelial cell marker CD34. Read More

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January 2018
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[Clinical, morphological, and prognostic features of papillary thyroid carcinoma with different BRAF mutational status assessed by immunohistochemistry].

Arkh Patol 2018 ;80(3):19-25

Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.

The somatic mutation in BRAF (BRAF), the data on the prognostic role of which are contradictory, is one of the most common molecular genetic abnormalities in the cells of papillary thyroid carcinoma (PTC).

Objective: To investigate the association of the immunoexpression of mutant BRAF in PTC with different morphological characteristics and long-term treatment results in patients.

Material And Methods: Information on inpatients with PTC was obtained from the database of the Pathology Department, A. Read More

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January 2018

Identifying and Understanding the Gaps in Care Experienced by Adolescent and Young Adult Cancer Patients at the University of Iowa Hospitals and Clinics.

J Adolesc Young Adult Oncol 2018 Jun 20. Epub 2018 Jun 20.

2 University of Iowa Hospitals and Clinics , Stead Family Children's Hospital, Iowa City, Iowa.

Purpose: In an effort to counteract the differences in improvement in survival rates of adolescents and young adults (AYA), compared to other age groups with cancer, the University of Iowa Hospitals and Clinics established an AYA cancer program. This study was conducted to gather feedback from AYAs in an effort to generate actionable data for program development.

Methods: The target population included patients aged 13-31 treated for malignancy in one of the following disease sites: central nervous system, leukemia, lymphoma, neuroendocrine, sarcoma, and thyroid. Read More

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June 2018
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Using Acutely Dissociated and Purified Oligodendrocyte Precursor Cells for High-Throughput Drug Screening to Identify Compounds that Promote Oligodendrocyte Differentiation.

Curr Protoc Cell Biol 2018 Jun;79(1):e49

Teva Pharmaceuticals Biologics Discovery, Redwood City, California.

Multiple sclerosis (MS) is an autoimmune disease that involves an immune-mediated inflammatory response in the central nervous system and optic nerve resulting in demyelination and neural degeneration, the cause of which is unknown. The adult central nervous system has the capacity to remyelinate axons by generating new oligodendrocytes (OLs). To identify clinical candidate compounds that may promote remyelination, we have developed a high-throughput screening (HTS) assay to identify compounds that promote the differentiation of oligodendrocyte precursor cells (OPCs) into OLs. Read More

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Heterogeneity of tissue IL-17 and tight junction proteins expression demonstrated in patients with autoimmune thyroid diseases.

Medicine (Baltimore) 2018 Jun;97(25):e11211

Institute of Anatomy and Anthropology.

Th17 cells together with their hallmark cytokine interleukin (IL)-17 were identified as crucial contributing factors in the pathogenesis of thyroid autoimmunity. The cytokine-regulated tight junction (Tj) disruption is thought to be essential in the initiation and/or development of several diseases. Still, the role of IL-17 maintaining Tj integrity in autoimmune thyroid diseases (AITDs) has not yet been evaluated. Read More

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June 2018
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Efficacy and Safety of Immunosuppressive Agents for Thyroid Eye Disease.

Authors:
Diego Strianese

Ophthalmic Plast Reconstr Surg 2018 Jun 18. Epub 2018 Jun 18.

King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia and Department of Neuroscience, Reproductive Sciences and Dentistry - University of Naples Federico II, Naples, Italy.

Purpose: To present an update on the efficacy and safety of immunosuppressive therapy for thyroid eye disease (TED) and to offer a general recommendation for management of TED, in light of these reports.

Methods: Data were retrieved from a literature search on PubMed, using the following words: thyroid eye disease, immunosuppressant, corticosteroid, methotrexate, azathioprine, cyclosporine, cyclophosphamide, rituximab, etanercept, adalimumab, tocilizumab, teprotumumab, adverse effects, side effects, and complications.

Results: Corticosteroids continue to be the primary medical therapy for TED. Read More

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Improvement in Both Primary and Eccentric Ocular Alignment After Thyroid Eye Disease-Strabismus Surgery With Tenon's Recession.

Ophthalmic Plast Reconstr Surg 2018 Jun 18. Epub 2018 Jun 18.

Department of Ophthalmology, Columbia-Presbyterian Medical Center, Edward S. Harkness Eye Institute, New York, New York, U.S.A.

Purpose: To evaluate the improvement in primary and eccentric gaze ocular alignment in thyroid eye disease (TED) patients undergoing horizontal strabismus surgery with Tenon's recession.

Methods: This is an Institutional Review Board-approved retrospective analysis of TED patients undergoing horizontal strabismus surgery for esotropia. The study included all patients from 2007 to 2016 operated on by a single surgeon at Columbia University Medical Center. Read More

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June 2018
3 Reads

Thyroid neoplasms: surgical and cyto-histopathological connections on a six year cases study.

G Chir 2018 May-Jun;39(3):158-165

Objective: This study aims to evaluate the percentage of cyto-histologic correlation in patients with a thyroid disease documented through clinical-instrumental, cytological (FNAB), histological and surgical examinations. The purpose of this study is also to determine the percentage of disease incidence and evaluating any surgical indication in relation to biological behavior (benign, malignant or indeterminate lesions, occult carcinomas), sex, and age.

Background: Almost all of thyroid neoplasms is manifested through thyroid nodule. Read More

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Relationship between serum cholesterol and Graves' orbitopathy (GO): a confirmatory study.

J Endocrinol Invest 2018 Jun 19. Epub 2018 Jun 19.

Endocrinology Units, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy.

Background: It has been suggested that high cholesterol represents a risk factor for Graves' orbitopathy (GO). In a recent cross-sectional study, a correlation between cholesterol and the presence of GO was found in patients with a Graves' disease (GD) of recent onset. To confirm this observation, we conducted a retrospective investigation in consecutive patients with GD. Read More

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Toxic effects of Lambda-cyhalothrin, on the rat thyroid: Involvement of oxidative stress and ameliorative effect of ginger extract.

Authors:
Wael M Al-Amoudi

Toxicol Rep 2018 12;5:728-736. Epub 2018 Jun 12.

Department of Biology, Faculty of Applied Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia.

Lambda-cyhalothrin (LCT) is a synthetic pyrethroid that is widely used to control insecticide. Ginger is a traditional plant that is widely used as a spice or folk medicine. This study evaluates the antioxidant effect of ginger extract on thyroid toxicity induced by LCT in albino rats. Read More

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June 2018
3 Reads

Editorial: "Homeostasis and Allostasis of Thyroid Function".

Front Endocrinol (Lausanne) 2018 5;9:287. Epub 2018 Jun 5.

Private Consultancy, Research and Development, Yandina, QLD, Australia.

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June 2018
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Neural and Endocrinal Pathobiochemistry of Vitiligo: Comparative Study for a Hypothesized Mechanism.

Front Endocrinol (Lausanne) 2018 25;9:197. Epub 2018 Apr 25.

Dermatology, Andrology and STDs Department, Faculty of Medicine, Al-Azhar University, Assuit Branch, Assuit, Egypt.

The etiology of vitiligo is still unclear. The aim is to investigate a neural and hormonal etio-pathology of vitiligo. Sixty acrofacial vitiligo patients were divided into two subgroups as active vitiligo patients group (AVPs;  = 35) and stable vitiligo patients group (SVP;  = 25). Read More

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April 2018
3 Reads

[Analysis of the diagnosis and treatment of Castleman disease originating in the head and neck].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jun;32(11):860-864

Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Zhengzhou University.

To improve diagnosis and treatment of Castleman' s disease (CD) originating in the head and neck.Of 15 cases of Castleman' s disease originating in the head and neck, 8 cases occurred in the right side of the neck, 6 cases in the left side, and 1 case in both sides. Eleven cases were focal type CD (UCD), and 4 cases were multi-center type CD (MCD). Read More

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[Oncological disease: dimensions of the phenomenon and role ionizing radiation].

G Ital Med Lav Ergon 2017 Nov;39(2):124-130

Dipartimento di Sanità pubblica, Medicina Sperimentale e Forense - Università di Pavia. Unità Operativa Ospedaliera di Medicina del lavoro (UOOML) - Fisiopatologia Respiratoria - IRCCS Fondazione "S. Maugeri" di Pavia.

Objectives: The continuous scientific advances against neoplastic diseases affecting all areas of oncology biomedical research. Age is an extremely important factor in cancer development, since the incidence of cancer increases significantly with age. Because of aging of the Italian population, although the incidence is kept constant, the number of cancer diagnosis is inevitably going to increase over time only to increasing age. Read More

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November 2017
2 Reads

High-Risk Factors for Suppurative Mastitis in Lactating Women.

Med Sci Monit 2018 Jun 19;24:4192-4197. Epub 2018 Jun 19.

Department of Breast and Thyroid Surger, Liaocheng People's Hospital, Liaocheng, Shandong, China (mainland).

BACKGROUND Acute mastitis is a common disease occurring in postpartum lactating women. This study aimed to identify the high-risk factors for suppurative mastitis (SM) in women who were breastfeeding. MATERIAL AND METHODS A total of 262 non-SM patients and 63 SM patients admitted to the Department of Breast and Thyroid Surgery of Liaocheng People's Hospital were retrospectively enrolled in this study. Read More

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An investigation into symptoms, diagnosis, treatment, and treatment complications in patients with retrosternal goiter.

J Family Med Prim Care 2018 Jan-Feb;7(1):224-229

Inflammatory Lung Disease Research Center, School of Medicine, Razi Hospital, Guilan University of Medical Science, Rasht, Iran.

Introduction: Retrosternal goiter refers to any thyroid enlargement in which over 50% of the thyroid permanently located under the thoracic inlet or the lower pole of thyroid is not palpable with the neck in hyperextended position. Due to the increasing number of surgical procedures of retrosternal goiter, the present study was carried out to examine the symptoms, diagnosis, treatment, and treatment complications in retrosternal goiter patients.

Materials And Methods: Data related to demographic data (age and gender), clinical symptoms (dyspnea, dysphagia, dysphonia, lumps in neck, and hoarseness), methods of diagnosis (computed tomography [CT], chest X-ray [CXR], ultrasonography, and magnetic resonance imaging), and postoperative complications (bleeding, early and late dysphonia, early and late dyspnea, transient and permanent hypocalcemia, transient, and permanent recurrent laryngeal nerve paralysis) were collected. Read More

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Free triiodothyronine level correlates with statin responsiveness in acute myocardial infarction.

J Geriatr Cardiol 2018 Apr;15(4):290-297

Departments of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Although thyroid hormone (TH) has important effects on lipid metabolism, the relationship between TH and statin responsiveness has never been investigated. We hypothesize that TH plays an important role in statin responsiveness in patients with acute myocardial infarction (AMI).

Methods: Consecutive 1091 hospitalized AMI patients in Fuwai hospital (Beijing, China) were enrolled into this current study. Read More

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April 2018
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Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.

Front Immunol 2018 4;9:1197. Epub 2018 Jun 4.

Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China.

Background: Inflammasomes, which mediate maturation of interleukin-1β (IL-β) and interleukin-18 (IL-18) and lead to pyroptosis, have been linked to various autoimmune disorders. This study investigated whether they are involved in the pathogenesis of autoimmune thyroiditis (AIT).

Methods: We collected thyroid tissues from 50 patients with AIT and 50 sex- and age-matched controls. Read More

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June 2018
1 Read

Non-Desmoglein Antibodies in Patients With Pemphigus Vulgaris.

Front Immunol 2018 4;9:1190. Epub 2018 Jun 4.

Department of Dermatology, University of California Irvine, Irvine, CA, United States.

Pemphigus vulgaris (PV) is a potentially life-threatening mucocutaneous autoimmune blistering disease. Patients develop non-healing erosions and blisters due to cell-cell detachment of keratinocytes (acantholysis), with subsequent suprabasal intraepidermal splitting. Identified almost 30 years ago, desmoglein-3 (Dsg3), a Ca-dependent cell adhesion molecule belonging to the cadherin family, has been considered the "primary" autoantigen in PV. Read More

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June 2018
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Immunological Profile and Predisposition to Autoimmunity in Girls With Turner Syndrome.

Front Endocrinol (Lausanne) 2018 4;9:307. Epub 2018 Jun 4.

Department of Paediatrics and Paediatric Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Objective: The risk of autoimmune diseases (AD) in patients with Turner Syndrome (TS) is twice higher than in the general female population and four times higher than in the male population. The causes of the increased incidence of AD in TS are still under discussion. We hypothesized the presence of a specific humoral, cellular, and regulatory T cell (Treg) immunity profile which predisposes to AD, disorders of immunity, and disorders of immune regulation. Read More

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Comparative assessment of Graves' disease and main extrathyroidal manifestation, Graves' ophthalmopathy, by non-targeted metabolite profiling of blood and orbital tissue.

Sci Rep 2018 Jun 18;8(1):9262. Epub 2018 Jun 18.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

Graves' disease (GD) is an autoimmune disorder that causes the overproduction of thyroid hormones and consequent cascade of systemic metabolism dysfunction. Moreover, Graves' ophthalmopathy (GO) is the main extrathyroidal manifestation of Graves' disease (GD). The goal of the study was to identify metabolic signatures in association with diagnostic biomarkers of GD without GO and GO, respectively. Read More

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Isolated thyroid metastasis from benign phyllodes tumour.

BMJ Case Rep 2018 Jun 17;2018. Epub 2018 Jun 17.

Department of Pathology, University of the Philippines Manila, Manila, Philippines.

We present a rare and interesting case of a 35-year-old woman who initially underwent an uneventful wide excision for a 13 cm left benign phyllodes tumour. She then noted a slowly growing left thyroid nodule 8 months postsurgery which on thyroidectomy 4 years later was shown to be a 6.9cm isolated thyroid metastasis from the phyllodes tumour. Read More

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June 2018
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Concurrent metastases of papillary thyroid carcinoma to the scalp and Meckel's cave.

BMJ Case Rep 2018 Jun 17;2018. Epub 2018 Jun 17.

Division of Dermatology, Washington University in Saint Louis School of Medicine, Saint Louis, Missouri, USA.

We present the case of a 65-year-old man with severe headaches and unilateral facial weakness, seen in consultation by the dermatology service to rule out primary cutaneous melanoma after brain imaging identified an enlarging mass within the right trigeminal (Meckel's) cave. Examination revealed only a pair of erythematous papules on the scalp, for which biopsy demonstrated metastatic papillary thyroid carcinoma. Further evaluation and subsequent thyroidectomy confirmed the origin of widespread internal disease, followed by definitive excision of scalp lesions and multimodal management of systemic involvement. Read More

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June 2018
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Combination therapy of ipilimumab and nivolumab induced thyroid storm in a patient with Hashimoto's disease and diabetes mellitus: a case report.

J Med Case Rep 2018 Jun 19;12(1):171. Epub 2018 Jun 19.

Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, 1750-1, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

Background: Recently, immune checkpoint inhibitors have widely been used for the management of advanced melanoma. However, high-grade immune-related adverse events can occur, particularly with combination immunotherapy. We report a case of a patient with melanoma who developed thyroid storm following treatment with ipilimumab and nivolumab. Read More

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June 2018
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A short review on human exposure to and tissue distribution of per- and polyfluoroalkyl substances (PFASs).

Sci Total Environ 2018 Sep 3;636:1058-1069. Epub 2018 May 3.

School of Environment, Guangzhou Key Laboratory of Environmental Exposure and Health, and Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, China. Electronic address:

PFASs are widely distributed in natural and living environment and can enter human bodies via different routes. Many studies have reported that PFASs may be associated with human diseases, such as urine acid and thyroid diseases. In this study, we reviewed PFAS levels in human bodies reported in past seven years, including blood, urine, milk, and tissues (hair and nails). Read More

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September 2018

Cystatin C as a predictor of mortality in elderly patients with chronic kidney disease.

Aging Male 2018 Jun 18:1-6. Epub 2018 Jun 18.

a Department of Nephrology, Clinic for Internal Medicine , University Clinical Centre Maribor , Maribor , Slovenia.

Background: The prevalence of chronic kidney disease (CKD) in the elderly is high. Serum cystatin C is an accurate marker of kidney function and it also has prognostic utility in CKD patients. The aim of our study was to determine the prediction of serum cystatin C and other markers of kidney function on long-term survival in elderly CKD patients. Read More

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Epidemiology of Swallowing Disorders in Rheumatoid Arthritis: Prevalence, Risk Factors, and Quality of Life Burden.

Ann Otol Rhinol Laryngol 2018 Jun 1:3489418780136. Epub 2018 Jun 1.

4 The Division of Rheumatology, Department of Internal Medicine, the University of Utah, Salt Lake City, Utah, USA.

Objective: This investigation examined the prevalence, symptoms, risk factors, and quality-of-life burden of swallowing disorders in rheumatoid arthritis (RA), a chronic, progressive autoimmune inflammatory disease.

Methods: One hundred individuals with RA (84 women, 16 men; mean age = 61.1 years, SD = 13. Read More

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Subclinical Hypothyroidism and Cardiac Risk: Lessons from a South Indian Population Study.

Indian J Endocrinol Metab 2018 Mar-Apr;22(2):217-222

Department of Endocrinology, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India.

Introduction: The benefits of treating subclinical hypothyroidism are currently under debate, prevention of adverse cardiac events purporting to be one of the main benefits. The effect of subclinical hypothyroidism on the cardiovascular health of the Indian sub-population is largely unknown. This study was designed to examine these effects and to help guide treatment of this disorder. Read More

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June 2018
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Sinonasal papilloma: what influences the decision to request a magnetic resonance imaging scan?

J Laryngol Otol 2018 Jun 18:1-7. Epub 2018 Jun 18.

Department of Otorhinolaryngology,Head and Neck and Thyroid Surgery,Liverpool,UK.

Background: Computed tomography is the standard pre-operative imaging modality for sinonasal papilloma. The complementary use of magnetic resonance imaging as an additional investigation is debated. This study aimed to establish whether magnetic resonance imaging can accurately detect tumour extent and is a useful adjunct to computed tomography. Read More

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Patients' knowledge about the outcomes of thyroid biopsy: a patient survey.

Endocrine 2018 Jun 16. Epub 2018 Jun 16.

Knowledge and Evaluation Research Unit in Endocrinology (KER-Endo), Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Medicine, Mayo Clinic, Rochester, MN, USA.

Purpose: Fine-needle aspiration biopsy of the thyroid is an increasingly common outpatient procedure. Patients are counseled about the indications and risks of this procedure and informed consent is obtained. We aimed to assess the extent to which patients acquired necessary knowledge during this process. Read More

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June 2018
2 Reads

Survival of aggressive variants of papillary thyroid carcinoma in patients under 55 years old: a SEER population-based retrospective analysis.

Endocrine 2018 Jun 16. Epub 2018 Jun 16.

Department of Thyroid Surgery, Guangzhou First People's Hospital, Guangzhou Medical University, 510180, Guangzhou, China.

Background: Patients younger than 55 years of age with papillary thyroid carcinoma (PTC) have excellent survival. Diffuse sclerosing variant (DSV) and tall cell variant (TCV) of PTC are associated with aggressiveness; the survival of patients <55 years of age with these variants is still unclear. We aim to investigate the clinicopathological features and survival of these variants in the age group <55 years. Read More

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June 2018
2 Reads

Graves' disease presenting as severe postpartum pruritus.

BMJ Case Rep 2018 Jun 15;2018. Epub 2018 Jun 15.

Family Medicine, Saint Joseph Hospital Family Medicine Residency, Denver, Colorado, USA.

A 39-year-old multigravida woman presented 3 weeks postpartum with worsening generalised pruritus without primary rash. Workup was significant for cholestasis and undiagnosed Graves' disease. She began to have symptomatic relief after starting methimazole, and liver function tests normalised as she became euthyroid. Read More

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June 2018
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Incident thyroid disease in female spouses of private pesticide applicators.

Environ Int 2018 Jun 13;118:282-292. Epub 2018 Jun 13.

Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Electronic address:

Background: Little is known about modifiable risk factors for thyroid disease. Several pesticides have been implicated in thyroid disruption, but clinical implications are not clear.

Objective: We assessed associations between pesticide use and other farm exposures and incident hypothyroidism and hyperthyroidism in female spouses of farmers in the Agricultural Health Study (AHS). Read More

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June 2018
2 Reads

Well-differentiated thyroid cancer and robotic transaxillary surgery at a North American institution.

J Surg Res 2018 Aug 11;228:170-178. Epub 2018 Apr 11.

Tulane University School of Medicine, Department of Surgery, New Orleans, Louisiana. Electronic address:

Background: Recent studies from Asia have reported the safety and feasibility of robotic-assisted thyroid surgery. In the United States, several small series and case reports have been published, mostly regarding treatment of benign disease. The aim of our study is to report the safety and feasibility of robotic surgery for well-differentiated thyroid cancer patients at a North American institution. Read More

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Transient receptor potential vanilloid-type 2 targeting on stemness in liver cancer.

Biomed Pharmacother 2018 Jun 12;105:697-706. Epub 2018 Jun 12.

Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The 2nd Xiangya Hospital, Central South University, Hunan Provincial Key Laboratory of Hepatobiliary Disease Research, Changsha, Hunan, 410011, China. Electronic address:

The malignant phenotype of the cells resulting from human liver cancer is driven by liver cancer stem-like cells (LCSLCs). Transient Receptor Potential Vanilloid-type 2 channel (TRPV2) contributes to the progression of different tumor types, including liver cancer. In the current study, the TRPV2 expression levels give rise to the effect on stemness in liver cancer cell lines. Read More

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June 2018
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Schmidt’s syndrome: a difficult diagnosis in the Latin American context

Rev Med Inst Mex Seguro Soc 2018 Mar-Apr;56(2):189-193

Facultad de Ciencias de la Salud, Escuela de Medicina, Departamento de Investigación. Lima, Perú

Background: Schmidt’s syndrome, also known as poliglandular autoimmune syndrome type 2, is a rare disease that has a prevalence between 1.5-4.5 cases per 100 000 inhabitants. Read More

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June 2018
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Surgical Treatment of Diplopia in Graves Orbitopathy Patients.

Ophthalmic Plast Reconstr Surg 2018 Jun 13. Epub 2018 Jun 13.

Department of Ophthalmology, Orbital Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Purpose: To review the authors' current understanding of motility dysfunction in patients with thyroid eye disease and to summarize appropriate evaluation and available management options.

Methods: Data were retrieved from a systematic search of the literature.

Results: Diplopia is one of the most disabling symptoms for Graves orbitopathy patients. Read More

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June 2018
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