163,109 results match your criteria Thyroid Disease


Diagnostic Accuracy of 18F-FDG PET/CT in Patients With Biochemical Evidence of Recurrent, Residual, or Metastatic Medullary Thyroid Carcinoma.

Clin Nucl Med 2018 Dec 17. Epub 2018 Dec 17.

From the PET Unit, Department of Nuclear Medicine-IDI, and Departments of.

Objective: Medullary thyroid carcinoma (MTC) is a rare malignancy. Location of residual, recurrent, or metastatic disease is crucial to treatment management and outcome. We aimed to evaluate the use of F-FDG PET/CT in localizing MTC foci in patients with biochemical relapse. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002414DOI Listing
December 2018

Risk factors for incidentally detected and symptomatic angiodysplasias: a case-control study with the general population as reference.

Eur J Gastroenterol Hepatol 2018 Dec 17. Epub 2018 Dec 17.

Departments of Gastroenterology and Hepatology.

Background: There is no literature on risk factors for incidentally found angiodysplasias. In clinical practice, endoscopists may defer treatment owing to uncertainty about a causal role of any found angiodysplasia and overt or occult bleeding. The objective is to identify risk factors that distinguish incidental angiodysplasias from angiodysplasias that are the cause of symptomatic bleeding. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001335DOI Listing
December 2018

Thyroid Dysfunction in Heart Failure and Cardiovascular Outcomes.

Circ Heart Fail 2018 Dec;11(12):e005266

Division of Endocrinology, Diabetes, and Metabolism (L.K., A.R.C.) at the Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

Background: The effects of thyroid dysfunction in patients with preexisting heart failure have not been adequately studied. We examined the prevalence of thyroid dysfunction and associations with cardiovascular outcomes in a large, prospective cohort of outpatients with preexisting heart failure.

Methods And Results: We examined associations between thyroid dysfunction and New York Heart Association class, atrial fibrillation, and a composite end point of ventricular assist device placement, heart transplantation, or death in 1365 participants with heart failure enrolled in the Penn Heart Failure Study. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005266DOI Listing
December 2018

Letter to the Editor: "Elevated serum tetrac in Graves Disease: Potential pathogenic role in thyroid-associated ophthalmopathy".

J Clin Endocrinol Metab 2018 Dec 17. Epub 2018 Dec 17.

Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.

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http://dx.doi.org/10.1210/jc.2018-02103DOI Listing
December 2018

An anatomical hypothesis: a "concentric-structured model" for the theoretical understanding of the surgical anatomy in the upper mediastinum required for esophagectomy with radical mediastinal lymph node dissection.

Dis Esophagus 2018 Dec 17. Epub 2018 Dec 17.

Department of Esophageal Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

Understanding the surgical anatomy is the key to reducing surgical invasiveness especially in the upper mediastinal dissection for esophageal cancer, which is supposed to have a significant impact on curability and morbidity. However, there is no theoretical recognition regarding the surgical anatomy required for esophagectomy, although the surgical anatomy in abdominal digestive surgery has been developed on the basis of embryological findings of intestinal rotation and fusion fascia. Therefore, we developed a hypothesis of a 'concentric-structured model' of the surgical anatomy in the upper mediastinum based on human embryonic development. Read More

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http://dx.doi.org/10.1093/dote/doy119DOI Listing
December 2018

Autoimmune diseases in autoimmune atrophic gastritis.

Acta Biomed 2018 Dec 17;89(8-S):100-103. Epub 2018 Dec 17.

Endoscopy Unit, Departement of Surgery, ULSS7-Pedemontana, Santorso Hospital, Santorso (VI), Italy.

Autoimmune diseases, characterized by an alteration of the immune system which results in a loss of tolerance to self antigens often coexist in the same patient. Autoimmune atrophic gastritis, characterized by the development of antibodies agains parietal cells and against intrinsic factor, leads to mucosal destruction that affects primarily the corpus and fundus of the stomach. Autoimmune atrophic gastritis is frequently found in association with thyroid disease, including Hashimoto's thyroiditis, and with type 1 diabetes mellitus, Other autoimmune conditions that have been described in association with autoimmune atrophic gastritis are Addison's disease, chronic spontaneous urticaria, myasthenia gravis, vitiligo, and perioral cutaneous autoimmune conditions, especially erosive oral lichen planus. Read More

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December 2018

Thyroid and celiac disease in pediatric age: a literature review.

Acta Biomed 2018 Dec 17;89(9-S):11-16. Epub 2018 Dec 17.

Gastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Chronic autoimmune thyroid disease or Hashimoto thyroiditis (HT) and Graves-Basedow disease (GD) are the main autoimmune thyroid diseases in pediatric age. Both are characterized by the production of anti-thyroid antibodies, by an infiltration of autoreactive B and T lymphocytes into the thyroid parenchyma and by alterations in thyroid function (hyperthyroidism in GD, normal function or subclinical hypothyroidism in HT with possible evolution towards manifest hypothyroidism). Celiac disease (CD) is a systemic autoimmune disease caused by gluten ingestion in genetically predisposed subjects, its prevalence is around 1% in Western Countries. Read More

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December 2018

American Head and Neck Society Endocrine Section clinical consensus statement: North American quality statements and evidence-based multidisciplinary workflow algorithms for the evaluation and management of thyroid nodules.

Head Neck 2018 Dec 18. Epub 2018 Dec 18.

Department of Otolaryngology, Massachusetts General Hospital, Boston, Massachusetts.

Background: Care for patients with thyroid nodules is complex and multidisciplinary, and research demonstrates variation in care. The objective was to develop clinical guidelines and quality metrics to reduce unwarranted variation and improve quality.

Methods: Multidisciplinary expert consensus and modified Delphi approach. Read More

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http://dx.doi.org/10.1002/hed.25526DOI Listing
December 2018

Chronic Urticaria and Osteoporosis: A longitudinal, Community-based Cohort Study of 11,944 Patients.

Br J Dermatol 2018 Dec 18. Epub 2018 Dec 18.

Siaal Research Center for Family Medicine and Primary Care, Division of Community Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Background: Chronic urticaria (CU) carries many risk factors for osteoporosis, but data on the relation between CU and osteoporosis are lacking.

Objective: To evaluate the association between CU and osteoporosis in a large community-based study.

Methods: A nationwide observational longitudinal cohort study was conducted. Read More

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http://dx.doi.org/10.1111/bjd.17528DOI Listing
December 2018

Idiopathic thyroid storm mimicking SIRS in a patient with hypothyroidism- a diagnostic dilemma.

J Community Hosp Intern Med Perspect 2018 11;8(6):368-369. Epub 2018 Dec 11.

Department of Internal Medicine, North Florida Regional Medical Center, University of Central Florida (Gainesville), Gainesville, FL, USA.

Thyroid storm, defined as an endocrine emergency in 1926, remains a challenge for physicians in the 21 century. The mortality rate of untreated thyroid storm is very high. Hence, if a thyroid storm is suspected, treatment should not be delayed. Read More

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http://dx.doi.org/10.1080/20009666.2018.1547090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292359PMC
December 2018

Retrosternal Goiter: A couple of classification methods with computed tomograpy findings.

Pak J Med Sci 2018 Nov-Dec;34(6):1494-1497

Dr. Pinar Celtikci, Department of Radiology, Kars Harakani State Hospital, Kars, Turkey.

Objectives: The retrosternal goiter (RSG), which can be defined by different classification and its incidence between 2% and 26% of all thyroidectomized patients, is a thyroid gland disease. Our aim was to classify RSG cases with a couple of different ways, which we have detected in computed tomography (CT) imaging of the thorax.

Methods: In this retrospective study conducted at Kars Harakani State Hospital Pulmonary Medicine Polyclinic between June 2014 and June 2017 in which 176 patients were included. Read More

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http://dx.doi.org/10.12669/pjms.346.15932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290211PMC
December 2018

The Pathology of Hyperthyroidism.

Front Endocrinol (Lausanne) 2018 3;9:737. Epub 2018 Dec 3.

Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, United States.

This article reviews those pathologic lesions which are associated with clinical and/or biochemical hyperthyroidism. Beginning with the descriptive pathology of classical Graves' disease and the less common toxic nodular goiter and hyper-functioning thyroid nodules, this paper describes the effects of non-thyroidal hormones, glandular function (including pituitary and hypothalamic lesions), ectopic production of thyroid stimulating proteins by non-thyroidal neoplasms, exogenous drug reactions causing hyper-function and finally conditions associated with a mechanic- destructive cause of hyperthyroidism. Read More

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http://dx.doi.org/10.3389/fendo.2018.00737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286962PMC
December 2018

Low Value of Thyroid Testing in the Pediatric Inpatient Setting.

Hosp Pediatr 2018 Dec 17. Epub 2018 Dec 17.

Division of Endocrinology, Children's National Health System and School of Medicine and Health Sciences, George Washington University, Washington, DC

Objectives: Our objective was to assess the frequency of pediatric inpatient thyroid testing, frequency of detection of abnormal results, and apparent impact on patient management.

Methods: This is a retrospective study of admissions from July 2015 to June 2016 at a large urban children's hospital. Chart review was conducted on all hospitalized pediatric patients who underwent thyroid testing. Read More

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http://dx.doi.org/10.1542/hpeds.2018-0101DOI Listing
December 2018

SLC30A10 transporter in the digestive system regulates brain manganese under basal conditions while brain SLC30A10 protects against neurotoxicity.

J Biol Chem 2018 Dec 17. Epub 2018 Dec 17.

Division of Pharmacology & Toxicology, The University of Texas at Austin, United States.

The essential metal manganese becomes neurotoxic at elevated levels. Yet, mechanisms by which brain manganese homeostasis is regulated are unclear. Loss-of-function mutations in SLC30A10, a cell surface-localized manganese efflux transporter in the brain and liver, induce familial manganese neurotoxicity. Read More

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http://dx.doi.org/10.1074/jbc.RA118.005628DOI Listing
December 2018

Epidemiology of parathyroid disorders.

Authors:
Sudhaker D Rao

Best Pract Res Clin Endocrinol Metab 2018 Dec 7. Epub 2018 Dec 7.

Division of Endocrinology, Diabetes, and Bone & Mineral Disorders, Bone & Mineral Research Laboratory, Henry Ford Hospital, Detroit, MI, USA. Electronic address:

Parathyroid disorders are not as uncommon as once believed. Both hyper- and hypoparathyroidism are more prevalent in women, but for different reasons. The female preponderance seen in primary hyperparathyroidism may be pathogenically linked, as it is more common after menopause. Read More

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http://dx.doi.org/10.1016/j.beem.2018.12.003DOI Listing
December 2018

Sexual Dimorphism of NADPH Oxidase/H₂O₂ System in Rat Thyroid Cells; Effect of Exogenous 17β-Estradiol.

Int J Mol Sci 2018 Dec 15;19(12). Epub 2018 Dec 15.

Department of Oncological Endocrinology, Medical University of Lodz, 7/9 Zeligowski St., 90-752 Lodz, Poland.

It has long been observed that females are more susceptible to thyroid diseases than males. Epidemiological and experimental data show that actions of hormonal factors-especially estrogens-may explain such disparity. However, the exact cause and mechanisms of this sexual dimorphism remain so far unknown. Read More

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http://dx.doi.org/10.3390/ijms19124063DOI Listing
December 2018

Proteomic Analysis of Zn Depletion/Repletion in the Hormone-Secreting Thyroid Follicular Cell Line FRTL-5.

Nutrients 2018 Dec 14;10(12). Epub 2018 Dec 14.

Research Centre for Food and Nutrition, CREA, Via Ardeatina 546, 00178 Rome, Italy.

Zinc deficiency predisposes to a wide spectrum of chronic diseases. The human Zn proteome was predicted to represent about 10% of the total human proteome, reflecting the broad array of metabolic functions in which this micronutrient is known to participate. In the thyroid, Zn was reported to regulate cellular homeostasis, with a yet elusive mechanism. Read More

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http://dx.doi.org/10.3390/nu10121981DOI Listing
December 2018

Axillary lymph node metastasis as the first manifestation of male occult breast cancer: A Case Report.

Medicine (Baltimore) 2018 Dec;97(50):e13706

Department of Radiotherapy, The Second Hospital of Jilin University, Changchun, Jilin Province, China.

Rational: Occult breast cancer (OBC) is an extremely rare breast cancer and is defined by the presence of axillary metastasis without a primary tumor in the breasts or any abnormality on radiologic examination.

Patient Concerns: This case report presents a 49-year-old man who was diagnosed with male OBC, which first manifested as an axillary lymph node metastasis followed by the emergence of infraclavicular lymph node metastasis. Neither the breast nor other organs had any abnormality. Read More

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http://dx.doi.org/10.1097/MD.0000000000013706DOI Listing
December 2018

T-Cell-Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028.

J Clin Oncol 2018 Dec 13:JCO2018782276. Epub 2018 Dec 13.

Patrick A. Ott, Dana-Farber Cancer Institute, Boston, MA; Yung-Jue Bang, Seoul National University College of Medicine, Seoul, The Republic of Korea; Sarina A. Piha-Paul, University of Texas MD Anderson Cancer Center, Houston, TX; Albiruni R. Abdul Razak, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Jaafar Bennouna, Centre Hospitalier Universitaire Nantes, Nantes; Jean-Charles Soria, University Paris-Sud and Gustave Roussy, Villejuif, France; Hope S. Rugo, University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA; Roger B. Cohen, University of Pennsylvania, Philadelphia, PA; Bert H. O'Neil, Indiana University, Bloomington, IN; Janice M. Mehnert, Rutgers Cancer Institute of New Jersey, New Brunswick; Razvan Cristescu, Ping Yang, Kenneth Emancipator, Karen Stein, Mark Ayers, Andrew K. Joe, and Jared K. Lunceford, Merck & Co., Inc., Kenilworth, NJ; Juanita Lopez, Institute of Cancer Research, London, United Kingdom; Toshihiko Doi, National Cancer Center Hospital East, Chiba, Japan; and Emilie M.J. van Brummelen, Netherlands Cancer Institute, Amsterdam, the Netherlands.

Purpose: Biomarkers that can predict response to anti-programmed cell death 1 (PD-1) therapy across multiple tumor types include a T-cell-inflamed gene-expression profile (GEP), programmed death ligand 1 (PD-L1) expression, and tumor mutational burden (TMB). Associations between these biomarkers and the clinical efficacy of pembrolizumab were evaluated in a clinical trial that encompassed 20 cohorts of patients with advanced solid tumors.

Methods: KEYNOTE-028 ( ClinicalTrials. Read More

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http://ascopubs.org/doi/10.1200/JCO.2018.78.2276
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http://dx.doi.org/10.1200/JCO.2018.78.2276DOI Listing
December 2018
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Clinicopathologic and Molecular Features of Metastatic Follicular Thyroid Carcinoma in Patients Presenting With a Thyroid Nodule Versus a Distant Metastasis.

Am J Surg Pathol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, University of Chicago Medical Center.

Metastatic follicular thyroid carcinoma (FTC) is rare. The aim of this study was to determine the clinical, histologic, and molecular differences between patients with metastatic FTC who present with distant metastatic (DM) disease versus those who present with a primary thyroid nodule (PT). Clinical and pathologic information was extracted from the medical record and surgical pathology report. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001208DOI Listing
December 2018

Efficacy and safety of dronedarone in patients with amiodarone-induced hyperthyroidism: a clinical study.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8502-8508

Division of Cardiology, University of Rome Tor Vergata, Rome, Italy.

Objective: The aim of the study was to examine the safety and efficacy of dronedarone in patients with a history of atrial fibrillation and amiodarone-induced hyperthyroidism.

Patients And Methods: We conducted a prospective study to evaluate the use of amiodarone and dronedarone in 124 patients with a history of paroxysmal atrial fibrillation who had no additional structural heart disease. All patients received amiodarone 200 mg qd. Read More

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December 2018

Risk of solid subsequent malignant neoplasms after childhood Hodgkin lymphoma-identification of high-risk populations to guide surveillance: A report from the Late Effects Study Group.

Cancer 2018 Dec 17. Epub 2018 Dec 17.

Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, Alabama.

Background: Survivors of Hodgkin lymphoma (HL) in childhood have an increased risk of subsequent malignant neoplasms (SMNs). Herein, the authors extended the follow-up of a previously reported Late Effects Study Group cohort and identified patients at highest risk for SMNs to create evidence for risk-based screening recommendations.

Methods: The standardized incidence ratio was calculated using rates from the Surveillance, Epidemiology, and End Results program as a reference. Read More

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http://dx.doi.org/10.1002/cncr.31807DOI Listing
December 2018

Prevalence of growth and endocrine disorders in Malaysian children with transfusion-dependent thalassaemia.

Singapore Med J 2018 Dec 17. Epub 2018 Dec 17.

Department of Paediatrics, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.

Introduction: Endocrine dysfunction due to iron overload secondary to frequent blood transfusions is a common complication in children with transfusion-dependent thalassaemia (TDT). We ascertained the prevalence of endocrine dysfunction in children with TDT seen in a hospital setting in Malaysia.

Methods: We reviewed all patients with TDT who had ≥ 8 blood transfusions per year. Read More

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http://dx.doi.org/10.11622/smedj.2018155DOI Listing
December 2018

Cancer Risk in Myotonic Dystrophy Type I: Evidence of a Role for Disease Severity.

JNCI Cancer Spectr 2018 Nov 10;2(4):pky052. Epub 2018 Dec 10.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Background: Myotonic dystrophy type 1 (DM1) is an inherited trinucleotide repeat disorder in which specific cancers have been implicated as part of the disease phenotype. This study aimed to assess whether cancer risk in DM1 patients is modified by disease severity.

Methods: Using the United Kingdom Clinical Practice Research Datalink (primary care electronic medical records), we identified a cohort of 927 DM1 and a matched cohort of 13 085 DM1-free individuals between January 1, 1988 and February 29, 2016. Read More

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http://dx.doi.org/10.1093/jncics/pky052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286884PMC
November 2018
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The epidemiological characteristics of patients with thyroid eye disease in a referral center in northern Iran.

J Curr Ophthalmol 2018 Dec 19;30(4):353-358. Epub 2018 Jul 19.

Eye Research Center, Guilan University of Medical Sciences, Rasht, Iran.

Purpose: This study was conducted to determine the demographics, clinical features, severity, and activity of thyroid eye disease (TED) in patients of a referral center in the north of Iran.

Methods: Patients with TED who were referred to Amir-Almomenin Hospital, Rasht, Iran from March 2012 to March 2014 were enrolled in this cross-sectional study. The measurements of proptosis, lid width, lagophthalmos, extraocular muscle function, and visual acuity were recorded. Read More

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http://dx.doi.org/10.1016/j.joco.2018.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276727PMC
December 2018

Segmental Maternal UPD of Chromosome 7q in a Patient With Pendred and Silver Russell Syndromes-Like Features.

Front Genet 2018 30;9:600. Epub 2018 Nov 30.

Division of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Research, IRCCS Istituto Auxologico Italiano, Milan, Italy.

Pendred syndrome (PS) is an autosomal recessive disorder due to mutations in the gene (chr7q22. 3) and characterized by sensorineural hearing loss and variable thyroid phenotype. Silver-Russell syndrome (SRS) is a heterogeneous imprinting disorder including severe intrauterine and postnatal growth retardation, and dysmorphic features. Read More

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http://dx.doi.org/10.3389/fgene.2018.00600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284021PMC
November 2018

and Thyroid: A Pleiotropic Candidate Gene for Congenital Hypothyroidism.

Front Endocrinol (Lausanne) 2018 29;9:730. Epub 2018 Nov 29.

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Variations in the transcription factor Gli-similar 3 () gene have been associated to variable congenital endocrine defects, including both morphogenetic and functional thyroid alterations. Evidence from Glis3 knockout mice indicates a relevant role for in thyroid hormone biosynthesis and postnatal thyroid gland growth, with a mechanism of action downstream of the TSH/TSHR interaction. However, the pathophysiological role of this transcription factor during the embryonic thyroid development remains unexplored. Read More

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http://dx.doi.org/10.3389/fendo.2018.00730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281699PMC
November 2018

Regional recurrence rate of lymph-node-positive thyroid carcinoma after selective or comprehensive neck dissection.

Oral Oncol 2018 Dec 13. Epub 2018 Dec 13.

Department of Dental Anesthesiology, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu 610041, China. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.034DOI Listing
December 2018

Developmental toxicity of kresoxim-methyl during zebrafish (Danio rerio) larval development.

Chemosphere 2018 Dec 8;219:517-525. Epub 2018 Dec 8.

Institute of Quality and Standard for Agro-products, Zhejiang Academy of Agricultural Sciences, State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Hangzhou, 310021, Zhejiang, China. Electronic address:

Kresoxim-methyl (KM) is a broad spectrum strobilurin fungicide that has been used widely on crops around the world. In the present study, we aimed to investigate the toxic effects of KM using various sublethal endpoints during zebrafish (Danio rerio) larval development. Results showed that the LC values of KM to zebrafish at multiple life stages (embryo, larvae, juvenile and adult) were 0. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.12.061DOI Listing
December 2018
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Long noncoding RNA H19 promotes vascular remodeling by sponging let-7a to upregulate the expression of cyclin D1.

Biochem Biophys Res Commun 2018 Dec 11. Epub 2018 Dec 11.

Department of Vascular Surgery, The First Hospital of China Medical University, Shenyang, 110001, China. Electronic address:

Vascular remodeling is mainly caused by excessive proliferation of vascular smooth muscle cells (VSMCs). Noncoding RNAs (ncRNAs) have emerged as important regulators in diverse pathological processes. Previous work has shown the functions and mechanisms of long noncoding RNA H19 (LncRNA H19) on VSMCs. Read More

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http://dx.doi.org/10.1016/j.bbrc.2018.11.185DOI Listing
December 2018
1 Read

Bony Orbital Volume Expansion in Thyroid Eye Disease.

Ophthalmic Plast Reconstr Surg 2018 Dec 7. Epub 2018 Dec 7.

Doheny Eye Institute, Division of Orbital and Ophthalmic Plastic Surgery, University of California-Los Angeles, Los Angeles, California, U.S.A.

Purpose: To quantify changes to the bony orbital volume (BOV) in patients with thyroid eye disease (TED) relative to normal controls.

Methods: In this case-control study, all patients affected with TED seen over a 2-year period were screened for study entry. Eligible participants were adults with clinical evidence of TED and CT scans of their orbits obtained during the course of their routine care. Read More

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http://Insights.ovid.com/crossref?an=00002341-900000000-9837
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http://dx.doi.org/10.1097/IOP.0000000000001292DOI Listing
December 2018
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[Analysis of clinicopathological characteristics of papillary thyroid carcinoma and BRAF V600E gene mutation].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1472-1476

Department of Pathology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an,710061, China.

To study the correlation between the BRAF V600E mutation and the clinicopathological features of papillary thyroid carcinoma(PTC), and to explore the application value of BRAF V600E mutation in PTC. The BRAF V600E gene mutation was detected in 108 PTC cases and 30 control cases by qPCR. The results were statistically analyzed by using SPSS 21. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.19.007DOI Listing
October 2018

[Robot-assisted transaxillary thyroidectomy: our early experience].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1051-1055

Department of Otolaryngology, Sun Yat-sen Memorial Hospital,Sun Yat-sen University, Guangzhou, 510120, China.

To evaluate the feasibility, effectiveness and safety of robot-assisted transaxillary thyroidectomy (RATT). The clinical data of 66 patients undergoing RATT from November 2016 to May 2018 were prospectively collected and analyzed. The average age was (38. Read More

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http://www.cnki.net/kcms/doi/10.13201/j.issn.1001-1781.2018.
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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.14.003DOI Listing
July 2018
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Role of MDM2 309T>G (rs2279744) and I/D (rs3730485) polymorphisms and haplotypes in risk of papillary thyroid carcinoma, tumor stage, tumor size, and early onset of tumor: A case control study.

J Cell Physiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Murine double minute clone 2 (MDM2) protein plays an important role in the regulation of p53 tumor suppressor. Genetic polymorphisms of the MDM2 gene are the candidate variants in susceptibility to various cancers. In the present study, we aimed to investigate the possible effects of MDM2 309T>G (rs2279744) and I/D (rs3730485) polymorphisms on papillary thyroid carcinoma (PTC) susceptibility and clinical or pathological features of the disease. Read More

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http://dx.doi.org/10.1002/jcp.27960DOI Listing
December 2018

The time point of completion thyroidectomy has no prognostic impact in patients with differentiated thyroid cancer.

Clin Endocrinol (Oxf) 2018 Dec 12. Epub 2018 Dec 12.

University Hospital Würzburg, Department of Nuclear Medicine, Würzburg, Germany.

Background: After partial resection of the thyroid gland a second operation referred to as "completion thyroidectomy" may be required if histopathological analysis indicates the presence of differentiated thyroid cancer (DTC). Although there is little evidence it is assumed that the time point of completion thyroidectomy is not critical for oncological prognosis of patients with DTC. We assessed whether patients with total thyroidectomy (TTx) in a two-step procedure have an equal long-term prognosis with regard to disease-specific survival compared to patients immediately undergoing total thyroidectomy in a one-step procedure. Read More

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http://dx.doi.org/10.1111/cen.13916DOI Listing
December 2018

Immunotherapy in selected patients with Down syndrome disintegrative disorder.

Dev Med Child Neurol 2018 Dec 12. Epub 2018 Dec 12.

Department of Pediatrics, Duke University Medical Center, Durham, NC, USA.

Down syndrome disintegrative disorder (DSDD) is an increasingly identified condition characterized by cognitive decline, autistic characteristics, insomnia, catatonia, and psychosis in adolescents and young adults with Down syndrome. Previously we reported a higher rate of autoimmune thyroid disease in these patients compared with unaffected individuals with Down syndrome. We therefore hypothesized DSDD may in some cases be immune-mediated. Read More

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http://dx.doi.org/10.1111/dmcn.14127DOI Listing
December 2018

Novel variants in SPTAN1 without epilepsy: An expansion of the phenotype.

Am J Med Genet A 2018 Dec 11. Epub 2018 Dec 11.

Office of the Clinical Director, NHGRI, and NIH Undiagnosed Diseases Program, Office of the Director, National Institutes of Health, Bethesda, Maryland.

We describe two unrelated children with de novo variants in the non-erythrocytic alpha-II-spectrin (SPTAN1) gene who have hypoplastic brain structures, intellectual disability, and both fine and gross motor impairments. Using agnostic exome sequencing, we identified a nonsense variant creating a premature stop codon in exon 21 of SPTAN1, and in a second patient we identified an intronic substitution in SPTAN1 prior to exon 50 creating a new donor acceptor site. Neither of these variants has been described previously. Read More

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http://dx.doi.org/10.1002/ajmg.a.40628DOI Listing
December 2018

Histopathological analysis of papillary thyroid carcinoma detected during ultrasound screening examinations in Fukushima.

Cancer Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Radiation Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.

Thyroid ultrasound screening of young residents in Fukushima prefecture of Japan demonstrated high detection rate of papillary thyroid carcinoma (PTC). Detailed morphological analysis of these tumors was not presented to date. This study sets out to evaluate changes in histopathological and invasive characteristics of Fukushima PTC with time after the nuclear accident of March 2011 in all available cases and in different age subgroups. Read More

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http://dx.doi.org/10.1111/cas.13912DOI Listing
December 2018

The oculoauriculofrontonasal syndrome: Further clinical characterization and additional evidence suggesting a nontraditional mode of inheritance.

Am J Med Genet A 2018 Dec 10. Epub 2018 Dec 10.

Centre de Génétique et Centre de Référence Anomalies du Développement et Syndromes Malformatifs de l'Interrégion Est, Centre Hospitalier Universitaire Dijon, Dijon, France.

The oculoauriculofrontonasal syndrome (OAFNS) is a rare disorder characterized by the association of frontonasal dysplasia (widely spaced eyes, facial cleft, and nose abnormalities) and oculo-auriculo-vertebral spectrum (OAVS)-associated features, such as preauricular ear tags, ear dysplasia, mandibular asymmetry, epibulbar dermoids, eyelid coloboma, and costovertebral anomalies. The etiology is unknown so far. This work aimed to identify molecular bases for the OAFNS. Read More

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http://dx.doi.org/10.1002/ajmg.a.40662DOI Listing
December 2018

Different outcomes in sporadic versus familial medullary thyroid cancer.

Head Neck 2018 Dec 11. Epub 2018 Dec 11.

Endocrine Unit, Department of Clinical Therapeutics, School of Medicine, National Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece.

Background: Medullary thyroid carcinoma (MTC) has varying clinical course with familial cases (fMTC) diagnosed earlier than sporadic MTC (spMTC).

Methods: A total of 273 MTCs (familial: n = 110 [40.3%], males: 38. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hed.25463
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http://dx.doi.org/10.1002/hed.25463DOI Listing
December 2018
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Thyroid Stimulating Hormone (TSH)/Insulin-like Growth Factor 1 (IGF1) Receptor Cross-talk in Human Cells.

Curr Opin Endocr Metab Res 2018 Oct 5;2:29-33. Epub 2018 Feb 5.

Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.

Thyroid stimulating hormone and insulin-like growth factor 1 receptors (TSHRs and IGF1Rs, respectively) interact leading to additive or synergistic stimulation of cellular responses. Recent findings provide evidence that the interaction between TSHRs and IGF1Rs is similar to that described for other G protein-coupled receptors and receptor tyrosine kinases. These types of interactions occur at or proximal to the receptors and are designated "receptor cross-talk. Read More

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http://dx.doi.org/10.1016/j.coemr.2018.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287758PMC
October 2018

Live birth following laparoscopic fertility-sparing surgery for papillary thyroid carcinoma arising from mature ovarian cystic teratoma: A case report.

Mol Clin Oncol 2018 Dec 5;9(6):613-616. Epub 2018 Oct 5.

Department of Obstetrics and Gynecology, Hashimoto Municipal Hospital, Hashimoto, Wakayama 648-0005, Japan.

Papillary thyroid carcinoma arising from ovarian mature cystic teratoma is clinically rare. We herein present a case of live birth following two laparoscopic surgeries for papillary thyroid carcinoma arising in a mature ovarian cystic teratoma. A 30-year-old female patient, gravida 1 para 1, was treated by laparoscopic bilateral ovarian cystectomy for suspicion of bilateral mature cystic teratoma. Read More

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http://dx.doi.org/10.3892/mco.2018.1743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256107PMC
December 2018

The prevalence and correlation between subclinical hypothyroidism and gall stone disease in Baghdad teaching hospital.

Ann Med Surg (Lond) 2019 Jan 30;37:7-10. Epub 2018 Nov 30.

Baghdad Medical City, Iraq.

Background: Gall stones are the most common biliary pathology. Subclinical hypothyroidism is not a common problem in the population with thyroid disease, several explanations for a possible relation between hypothyroidism and lipid metabolism, gall stone formation proved that prevalence of gall stones is increased in patients with hypothyroidism disease.

Objective: To find the prevalence and correlation between the subclinical hypothyroidism and gall stone disease. Read More

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http://dx.doi.org/10.1016/j.amsu.2018.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282189PMC
January 2019

Targeted next-generation sequencing of cancer-related genes in thyroid carcinoma: A single institution's experience.

Oncol Lett 2018 Dec 2;16(6):7278-7286. Epub 2018 Oct 2.

Department of Biology and Genetics, Laboratory of Cancer Medical Science, Hokuto Hospital, Obihiro, Hokkaido 080-0833, Japan.

Thyroid carcinoma (TC) has characteristic genetic alterations, including point mutations in proto-oncogenes and chromosomal rearrangements that vary by histologic subtype. Recent developments in next-generation sequencing (NGS) technology enable simultaneous analysis of cancer-associated genes of interest, thus improving diagnostic accuracy and allowing precise personalized treatment for human cancer. A total of 50 patients who underwent thyroidectomy between 2014 and 2016 at Hokuto Hospital were enrolled. Read More

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http://dx.doi.org/10.3892/ol.2018.9538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256352PMC
December 2018

Lenvatinib as a novel treatment for anaplastic thyroid cancer: A retrospective study.

Oncol Lett 2018 Dec 5;16(6):7271-7277. Epub 2018 Oct 5.

Department of Breast and Endocrine Surgery, Kanagawa Cancer Center, Yokohama, Kanagawa 241-8515, Japan.

Anaplastic thyroid cancer (ATC) is associated with an extremely poor prognosis and is resistant to the majority of chemotherapies. In 2015, lenvatinib was approved for treating ATC in Japan. The present study aimed to evaluate the overall survival (OS) of patients with ATC treated with lenvatinib. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9553
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http://dx.doi.org/10.3892/ol.2018.9553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256365PMC
December 2018
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Understanding nationwide readmissions after thyroid surgery.

Surgery 2018 Dec 10. Epub 2018 Dec 10.

Department of Surgery, Thyroid and Parathyroid Surgery Program, Thomas Jefferson University Hospital, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA. Electronic address:

Background: The 30-day readmission rate is increasingly utilized as a metric of quality that impacts reimbursement. To date, there are no nationally representative data on readmission rates after thyroid surgery. We aimed to determine national readmission rates after inpatient thyroidectomy operations and whether select clinical factors were associated with increased odds of postthyroidectomy readmission. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00396060183065
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http://dx.doi.org/10.1016/j.surg.2018.09.007DOI Listing
December 2018
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Faecal Short Chain Fatty Acids Profile is Changed in Polish Depressive Women.

Nutrients 2018 Dec 7;10(12). Epub 2018 Dec 7.

Department of Biochemistry and Human Nutrition, Pomeranian Medical University, 71-460 Szczecin, Poland.

Short chain fatty acids (SCFAs) being produced during fermentation of non-digestible polysaccharides are regulatory compounds with the potential to influence inflammatory, as well as emotional state and cognition through the gut⁻brain axis. We analyzed the association between stool concentration of SCFAs (acetic acid (C 2:0), propionic acid (C 3:0), isobutyric acid (C 4:0 ), butyric acid (C 4:0 ), isovaleric acid (C 5:0 ) valeric acid (C 5:0 ), isocaproic acid (C 6:0 ), caproic acid, and (C 6:0 ) heptanoic acid (C 7:0)) and depressive symptoms among women and looked for the potential confounders of microbiota byproduct synthesis. We enrolled 116 women aged 52. Read More

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http://dx.doi.org/10.3390/nu10121939DOI Listing
December 2018

Thyroid incidentaloma as a "PAIN" phenomenon- does it always require surgery?

Medicine (Baltimore) 2018 Dec;97(49):e13339

First Department and Clinic of General, Gastroenterological and Endocrine Surgery.

A thyroid nodule discovered during imaging study performed due to unrelated thyroid disease is known as a thyroid incidentaloma, while positron emission tomography (PET) associated incidental neoplasm of thyroid is known as a "PAIN" phenomenon.To evaluate which patients with "PAIN" phenomenon should undergo surgery in regards to cytology results.Retrospective review of 4716 patients consecutively admitted and surgically treated in tertiary surgical center. Read More

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http://dx.doi.org/10.1097/MD.0000000000013339DOI Listing
December 2018

The diagnostic accuracy of contrast-enhanced ultrasound for the differentiation of benign and malignant thyroid nodules: A PRISMA compliant meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13325

Department of General Surgery, People's Hospital of Rizhao, Rizhao, China.

Background: Contrast-enhanced ultrasound (CEUS) is a non-invasive method that has been used in the diagnosis of several diseases. Recently, CEUS has been used in the differentiation of benign and malignant thyroid nodules. However, the performance of CEUS in thyroid nodules has not been studied clearly. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812070-0002
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http://dx.doi.org/10.1097/MD.0000000000013325DOI Listing
December 2018
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General hyperpigmentation induced by Grave's disease: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13279

Department of Endocrinology, The Second Affiliated Hospital of Zhejiang University School of Medicine.

Rationale: Hyperpigmentation is a common skin disease. However, there are few reported cases of Grave's disease with diffuse hyperpigmentation. We hereby described a rare case with diffuse hyperpigmentation induced by Grave's disease. Read More

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http://dx.doi.org/10.1097/MD.0000000000013279DOI Listing
December 2018