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    Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study.
    Int J Cancer 2017 Nov 23. Epub 2017 Nov 23.
    Nutrition and Metabolism Section, International Agency for Research on Cancer, Lyon, France.
    Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin(IL)-6, IL-10 and TNF-α and the risk of TC. Read More

    Aging-Related Disease Risks among Young Thyroid Cancer Survivors.
    Cancer Epidemiol Biomarkers Prev 2017 Nov 22. Epub 2017 Nov 22.
    Division of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, Utah.
    Background: Thyroid cancer is the most rapidly increasing cancer in the United States, affects a young population, has high survival, and is one of the most common cancers in people under age 40. The aim of this study was to examine the risks of aging-related diseases in a statewide sample of thyroid cancer survivors who were diagnosed <40 years compared with those diagnosed ≥40 and a cancer-free sample.Methods: Thyroid cancer survivors diagnosed 1997 to 2012 were matched to up to 5 cancer-free individuals on birth year, sex, birth state, using the statewide Utah Population Database. Read More

    Pregnancy outcomes among women with asthma.
    J Matern Fetal Neonatal Med 2017 Nov 22:1-7. Epub 2017 Nov 22.
    a Department of Obstetrics and Gynecology , Jewish General Hospital, McGill University , Montreal , Canada.
    Purpose: The purpose of this study is to examine the association between maternal asthma and pregnancy, delivery and neonatal outcomes.

    Materials And Methods: We carried out a retrospective cohort study using the Health Care Cost and Utilization Project-Nationwide Inpatient Sample (HCUP-NIS) database from 2003 to 2011. Among women who delivered during this time period, we compared pregnancy, delivery, and neonatal outcomes in asthmatics versus non-asthmatics. Read More

    Thyroid Stimulating Hormone Within the Reference Range is Associated with Visceral Adiposity Index and Lipid Accumulation Product: A Population-Based Study of SPECT-China.
    Horm Metab Res 2017 Nov 17. Epub 2017 Nov 17.
    Institute and department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
    Few studies about the relationship of thyroid stimulating hormone (TSH) level with visceral adiposity index (VAI) and lipid accumulation product (LAP) in large Chinese population are available. The aim of this study was to explore whether TSH level within the reference range was associated with these two newer reliable cardiovascular risk factors. The data were obtained from a cross-sectional study (SPECT-China study, 2014-2015), which was based on the population. Read More

    BRAF V600E Mutation-Assisted Risk Stratification of Solitary Intrathyroidal Papillary Thyroid Cancer for Precision Treatment.
    J Natl Cancer Inst 2017 Nov 18. Epub 2017 Nov 18.
    Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Endocrinology and Metabolism and the Shanghai Research Center of Thyroid Diseases, The Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China; Endocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy; Department of Internal Medicine, University of Perugia, Perugia, Italy; Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, and Department of Pathophysiology and Transplantation, University of Milan, Milan Italy; Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland; Cancer Molecular Pathology of School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia; Department of Medicine, Endocrinology Unit, University of Padua, Padua, Italy; Veneto Institute of Oncology, IRCCS, Padua, Italy; University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Endocrinology and Nutrition Hospital Universitario La Paz and Hospital, Universitario de Mostoles, 28029 Madrid, Spain; Biomedical Research Institute "Alberto Sols," Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, 28029 Madrid, Spain; Ciberonc, Health Institute Carlos III, 28029 Madrid, Spain; Endocrine Surgical Unit, The University of Sydney, Sydney, Australia.
    Background: Precise risk stratification-based treatment of solitary intrathyroidal papillary thyroid cancer (SI-PTC) that is larger than 1.0 cm and 4.0 cm or less is undefined. Read More

    Increased global DNA hypomethylation in distant metastatic and dedifferentiated thyroid cancer.
    J Clin Endocrinol Metab 2017 Nov 20. Epub 2017 Nov 20.
    Consortium for the Study of Thyroid Cancer (CECaT), Catalonia, Spain.
    Introduction: Global DNA hypomethylation is a major event for the development and progression of cancer, although the significance in thyroid cancer remains unclear. Therefore, we aimed to investigate its role in thyroid cancer progression and its potential as a prognostic marker.

    Methods: Global hypomethylation of Alu repeats was used as a surrogate marker for DNA global hypomethylation, and was assessed using the Quantification of Unmethylated Alu (QUAlu) technique. Read More

    Nitroxides as Antioxidants and Anticancer Drugs.
    Int J Mol Sci 2017 Nov 22;18(11). Epub 2017 Nov 22.
    Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 90-136 Lodz, Poland.
    Nitroxides are stable free radicals that contain a nitroxyl group with an unpaired electron. In this paper, we present the properties and application of nitroxides as antioxidants and anticancer drugs. The mostly used nitroxides in biology and medicine are a group of heterocyclic nitroxide derivatives of piperidine, pyrroline and pyrrolidine. Read More

    The Hokkaido Birth Cohort Study on Environment and Children's Health: cohort profile-updated 2017.
    Environ Health Prev Med 2017 May 18;22(1):46. Epub 2017 May 18.
    Hokkaido University Center for Environmental and Health Sciences, Kita 12, Nishi 7, Kita-ku, Sapporo, 060-0812, Japan.
    The Hokkaido Study on Environment and Children's Health is an ongoing study consisting of two birth cohorts of different population sizes: the Sapporo cohort and the Hokkaido cohort. Our primary study goals are (1) to examine the effects of low-level environmental chemical exposures on birth outcomes, including birth defects and growth retardation; (2) to follow the development of allergies, infectious diseases, and neurobehavioral developmental disorders and perform a longitudinal observation of child development; (3) to identify high-risk groups based on genetic susceptibility to environmental chemicals; and (4) to identify the additive effects of various chemicals, including tobacco smoking. The purpose of this report is to update the progress of the Hokkaido Study, to summarize the recent results, and to suggest future directions. Read More

    Expression of cancer/testis antigens MAGE-A, MAGE-C1, GAGE and CTAG1B in benign and malignant thyroid diseases.
    Oncol Lett 2017 Dec 26;14(6):6485-6496. Epub 2017 Sep 26.
    Division of Pathology Diagnostic Services, Cytology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
    Despite considerable advances in the understanding of thyroid gland biology, correctly diagnosing thyroid nodules and treating high-grade thyroid carcinoma remains challenging. Cancer/testis (CT) antigens have emerged as potential diagnostic tools as well as targets of potential cancer vaccinations. In the present study, a total of 117 patients who underwent surgical therapy for thyroid disease were available for analysis. Read More

    HHV-6A/6B Infection of NK Cells Modulates the Expression of miRNAs and Transcription Factors Potentially Associated to Impaired NK Activity.
    Front Microbiol 2017 31;8:2143. Epub 2017 Oct 31.
    Section of Microbiology and Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
    Natural killer (NK) cells have a critical role in controlling virus infections, and viruses have evolved several mechanisms to escape NK cell functions. In particular, Human herpesvirus 6 (HHV-6) is associated with diseases characterized by immune dysregulation and has been reported to infect NK cells. We recently found that HHV-6 in vitro infection of human thyroid follicular epithelial cells and T-lymphocytes modulates several miRNAs associated with alterations in immune response. Read More

    Clinical, Genetic, and Protein Structural Aspects of Familial Dysalbuminemic Hyperthyroxinemia and Hypertriiodothyroninemia.
    Front Endocrinol (Lausanne) 2017 1;8:297. Epub 2017 Nov 1.
    Department of Molecular Medicine, University of Pavia, Pavia, Italy.
    Familial dysalbuminemic hyperthyroxinemia (FDH-T4) and hypertriiodothyroninemia (FDH-T3) are dominantly inherited syndromes characterized by a high concentration of thyroid hormone in the blood stream. The syndromes do not cause disease, because the concentration of free hormone is normal, but affected individuals are at risk of erroneous treatment. FDH-T4 is the most common cause of euthyroid hyperthyroxinemia in Caucasian populations in which its prevalence is about 1 in 10,000 individuals, but the prevalence can be much higher in some ethnic groups. Read More

    Vitiligo and Autoimmune Thyroid Disorders.
    Front Endocrinol (Lausanne) 2017 27;8:290. Epub 2017 Oct 27.
    Department of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
    Vitiligo represents the most common cause of acquired skin, hair, and oral depigmentation, affecting 0.5-1% of the population worldwide. It is clinically characterized by the appearance of disfiguring circumscribed skin macules following melanocyte destruction by autoreactive cytotoxic T lymphocytes. Read More

    Primary Ewing Sarcoma of the Thyroid-Eight Cases in a Decade: A Case Report and Literature Review.
    Front Endocrinol (Lausanne) 2017 27;8:257. Epub 2017 Oct 27.
    Department of Surgical Oncology, Medical University of Gdańsk, Gdańsk, Poland.
    Sarcomas represent less than 1% of all malignant tumors found in the thyroid. Of these, primary extraosseoussarcoma has been reported only a few times in the past decade. We present the case of a 34-year-old male who had a fast-growing hard mass in the lower left neck. Read More

    [Thyrotropin reference ranges during pregnancy in the province of Huelva, Spain].
    Semergen 2017 Nov 18. Epub 2017 Nov 18.
    Centro de Salud El Torrejón, Huelva, España.
    Objective: The correct diagnosis of hypothyroidism during pregnancy requires knowledge of the local trimester-specific thyrotropin (TSH) reference ranges. When these are not available, the guidelines recommend upper limits of 2.5, 3. Read More

    Sustained attention in school-age children with congenital hypothyroidism: Influence of episodes of overtreatment in the first three years of life.
    Neurologia 2017 Nov 18. Epub 2017 Nov 18.
    Instituto Superior de Diseño, Universidad de La Habana, Instituto de Neurología y Neurocirugía de La Habana, La Habana, Cuba.
    Introduction: Children with congenital hypothyroidism (CH) are at risk of developing mild cognitive impairment despite normal overall intellectual performance. These deficits may be caused by disease-related and treatment-related factors. This study explores the impact of abnormal thyroid function during the first 3 years of life on attention performance at school age. Read More

    Real world experience with targeted therapy for the treatment of anaplastic thyroid carcinoma.
    Thyroid 2017 Nov 22. Epub 2017 Nov 22.
    University of Texas M.D. Anderson Cancer Center, Endocrine Neoplasia and Hormonal Disorders , 1515 Holcombe Blvd, unit 1461 , Houston, Texas, United States , 77030 ;
    Background: Patients with anaplastic thyroid cancer (ATC) have a dismal prognosis despite systemic cytotoxic chemotherapy. Our objective was to study the efficacy and safety of targeted therapy in ATC patients when used outside of a clinical trial.

    Methods: This is a retrospective review from April 2015 to May 2016 at a single academic institution where we studied 16 ATC patients receiving targeted therapy outside of a clinical trial. Read More

    Normal menstrual cycle steroid hormones variation does not affect the blood levels of total adiponectin and its multimer forms.
    J Clin Transl Endocrinol 2015 Jun 18;2(2):61-65. Epub 2015 Mar 18.
    Research Laboratory, Department of Endocrinology and Metabolic Diseases, Larissa University Hospital, School of Medicine, University of Thessaly, Biopolis, Larissa 41110, Greece.
    Objective: Plasma total adiponectin reveals a sexual dimorphism indicating that gonadal steroids may be involved in its secretion and/or metabolism. However, results from previous reports are conflicting and data regarding the influence of ovarian steroids on adiponectin's multimer forms are scarce. The objective of the study was to assess if total adiponectin and its isoforms are affected by the changes of estradiol and progesterone during the normal menstrual cycle and the association of total adiponectin and its isoforms with the gonadal steroid levels. Read More

    Outcomes of hospitalized diabetic foot patients in a multi-disciplinary team setting: Thailand's experience.
    J Clin Transl Endocrinol 2014 Dec 15;1(4):187-191. Epub 2014 Oct 15.
    Diabetes and Thyroid Center, Theptarin Hospital, 3858 Rama IV Rd, Klong Toey, Bangkok 10110, Thailand.
    Aims: The aims of this study were to evaluate the outcomes of treatment among hospitalized patients with diabetic foot ulcers, the risk factors for non-healing ulcers, and the rate of major amputation among Thai patients.

    Methods: A retrospective study of hospitalized diabetic foot patients treated at Theptarin Hospital during the period of 2009-2013. The complete healing rate was assessed at 12 months after admission. Read More

    The value of neck circumference (NC) as a predictor of non-alcoholic fatty liver disease (NAFLD).
    J Clin Transl Endocrinol 2014 Dec 23;1(4):133-139. Epub 2014 Jul 23.
    Department of Endocrinology, Changhai Hospital, Shanghai 200433, PR China.
    Aims: To analyze the correlation between neck circumference (NC) and non-alcoholic fatty liver disease (NAFLD) and compare the predictive value of NC for NAFLD with that of other simple anthropometric measures and other biochemical profiles.

    Methods: 2761 subjects, undergoing a medical check-up at the Changhai Hospital between October 01, 2012 and November 30, 2012, were recruited to the study. NC, other simple anthropometric measures, and biochemical profiles were analyzed. Read More

    Cotton rats (Sigmodon hispidus) possess pharyngeal pouch remnants originating from different primordia.
    Histol Histopathol 2017 Nov 21:11946. Epub 2017 Nov 21.
    Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
    Pharyngeal pouches in mammals develop into specific derivatives. If the differentiation of the pharyngeal pouches is anomalous, their remnants can result in cysts, sinuses, and fistulae in the differentiated organs or around the neck. In the present study, we found several pharyngeal pouch remnants, such as cystic structures in thymus and parathyroid gland and fossulae extended from the piriform fossa, in the inbred cotton rats maintained at Hokkaido Institute of Public Health (HIS/Hiph) and University of Miyazaki (HIS/Mz). Read More

    Recent Pregnancy is Not Associated with High-Risk Pathological Features of Well-Differentiated Thyroid Cancer.
    Thyroid 2017 Nov 21. Epub 2017 Nov 21.
    UCLA David Geffen School of Medicine, Division of Endocrinology, Diabetes, and Nutrition; Department of Medicine, Los Angeles, California, United States.
    Background: Thyroid cancer is commonly diagnosed in the first postpartum year, supporting the theory that high levels of estrogen may stimulate progression of hormone-mediated thyroid cancer. The aim of this study was to assess the effect of recent pregnancy on histopathologic disease characteristics of well-differentiated thyroid cancer (WDTC).

    Methods: Cases of WDTC (1999-2012) were identified from the California Cancer Registry and linked to data from the Office of Statewide Health Planning and Development. Read More

    Rutin Scavenges Reactive Oxygen Species, Inactivates 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK) and Increases NIS expression in thyroid PCCL3 Cells.
    Thyroid 2017 Nov 21. Epub 2017 Nov 21.
    Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho , Av. Carlos Chagas Filho, 373 , Bloco G - 1o andar - sala: G1-60 , CCS - Ilha do Fundão , Rio de Janeiro, Rio de Janeiro, Brazil , 21.941-902 ;
    Background: Thyroid iodide uptake, mediated by the sodium-iodide symporter (NIS), is essential for thyroid hormone synthesis and also for treatment of thyroid diseases, such as thyroid cancer, through radioiodine therapy. Therefore, compounds able to increase thyroid iodide uptake could be clinically useful, and it is of great importance to unravel the mechanisms underlying such effect. We have previously shown that the flavonoid rutin increases thyroid radioiodide uptake in vivo, in rats. Read More

    Irisin as a regulator of bone and glucose metabolism: a narrative review.
    Minerva Endocrinol 2017 Nov 20. Epub 2017 Nov 20.
    Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy -
    In humans, irisin is produced mainly by skeletal muscle in response to physical activity. It has been demonstrated that irisin plays a pivotal role in inducing fat browning and regulating energy expenditure. New findings from various studies conducted in both animals and humans suggest that irisin can affect bone and glucose metabolism. Read More

    High-resolution melting analysis (HRM) for mutational screening of Dnajc17 gene in patients affected by thyroid dysgenesis.
    J Endocrinol Invest 2017 Nov 20. Epub 2017 Nov 20.
    Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli "Federico II", Via S. Pansini, 5, 80131, Naples, Italy.
    Background: Congenital hypothyroidism is a frequent disease occurring with an incidence of about 1/1500 newborns/year. In about 75% of the cases, CH is caused by alterations in thyroid morphogenesis, defined "thyroid dysgenesis" (TD). TD is generally a sporadic disease but in about 5% of the cases a genetic origin has been demonstrated. Read More

    Dosing of radioactive iodine in end-stage renal disease patient with thyroid cancer.
    Endocrinol Diabetes Metab Case Rep 2017 10;2017. Epub 2017 Nov 10.
    Division of Endocrinology, Department of Medicine.
    We describe detailed administration of thyroidal and extrathyroidal doses of radioiodine to a patient with end-stage renal disease on hemodialysis. A thorough description of area under curve measurements in a patient with compromised renal function has rarely been described in the literature. Few publications have described thyroid cancer management of patients on hemodialysis, and we believe our management will aid in patient treatment in the future. Read More

    Correlation between Insulin Resistance and Thyroid Nodule in Type 2 Diabetes Mellitus.
    Int J Endocrinol 2017 12;2017:1617458. Epub 2017 Oct 12.
    Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
    Objective: The present study explored the association between insulin resistance (IR) and the clinical characteristics of thyroid nodules in patients with type 2 diabetes mellitus (T2DM).

    Methods: All the patients were newly diagnosed with T2DM. 201 patients with thyroid nodule disease and 308 patients without the nodular thyroid disease. Read More

    Dynamic profile of differentiated thyroid cancer in male and female patients with thyroidectomy during 2000-2013 in China: a retrospective study.
    Sci Rep 2017 Nov 20;7(1):15832. Epub 2017 Nov 20.
    Department of Endocrinology, Chinese PLA General Hospital, Beijing, 100853, China.
    The study aimed to investigate the gender-related differences of disease onset, age distribution, blood type, clinical characteristics, and malignant behaviors of differentiated thyroid carcinoma (DTC) in Chinese patients. A total of 7385 consecutive thyroid cancer patients who underwent thyroidectomy were retrospectively reviewed. 4087 (55. Read More

    Next generation panel sequencing identifies NF1 germline mutations in three patients with pheochromocytoma but no clinical diagnosis of Neurofibromatosis Type 1.
    Eur J Endocrinol 2017 Nov 20. Epub 2017 Nov 20.
    B Klink, Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, TU Dresden, Fetscherstraße 74, 01307 Dresden, Germany.
    Objective Our objective was to improve molecular diagnostics in patients with hereditary pheochromocytoma and paraganglioma (PPGL) by using next generation sequencing (NGS) multi-gene panel analysis. Derived from this study we here present three cases that were diagnosed with NF1 germline mutations but did not have a prior clinical diagnosis of Neurofibromatosis Type 1 (NF1). Design We performed genetic analysis of known tumor predisposition genes, including NF1, using a multi-gene NGS enrichment-based panel applied to a total of 1029 PPGL patients. Read More

    Autoimmune thyroid diseases and Th17/Treg lymphocytes.
    Life Sci 2017 Nov 17. Epub 2017 Nov 17.
    Department of Geriatrics, Affiliated Hospital of Jianghan University, Wuhan 430015, PR China. Electronic address:
    Years of researches have demonstrated that the imbalance of Th17 and Tregs contribute to the thyroid autoimmunity and the severity of autoimmune thyroid disease (AITD). The underlying mechanism comprises inherent genetic predisposition, abnormality of Th17 and Treg related biological molecules, and gut microbiota disorder. New therapeutic strategies have been developed to improve the Th17/Treg equilibrium, including regulation of intracellular signaling pathways, neutralization of Th17-related cytokines, as well as manipulation of Th17 and Treg specific transcription factors. Read More

    The first postoperative-stimulated serum thyroglobulin is a prognostic factor for thyroid microcarcinomas.
    Braz J Otorhinolaryngol 2017 Oct 31. Epub 2017 Oct 31.
    Universidade Estadual Paulista "Júlio de Mesquita Filho" (Unesp), Faculdade de Medicina de Botucatu, Departamento de Medicina Interna, Botucatu, SP, Brazil. Electronic address:
    Introduction: Endogenous thyroid-stimulating hormone-stimulated thyroglobulin collected after total thyroidectomy is a useful predictor of better prognosis in patients with differentiated thyroid carcinomas in general, but studies with microcarcinomas are scarce.

    Objective: To assess whether the first postoperative stimulated thyroglobulin measurement is a prognostic factor in patients with microcarcinoma.

    Methods: The medical data of 150 differentiated thyroid carcinoma patients were studied retrospectively, and 54 (36%) cases with microcarcinoma were selected. Read More

    Relationship of paratracheal lymph nodes with the progression of chronic autoimmune thyroiditis: 5-year follow-up results
    Turk J Med Sci 2017 08 23;47(4):1173-1179. Epub 2017 Aug 23.
    Background/aim: To examine changes in paratracheal lymph nodes (PLNs) and the relationship with the course of the disease in patients with chronic autoimmune thyroiditis (CAT) 5 years after diagnosis. Materials and methods: A total of 169 patients with newly diagnosed CAT and 53 healthy subjects were included in the study. All patients underwent ultrasonographic (US) examinations of the thyroid, paratracheal regions, and examined thyroid function tests. Read More

    Mixed subtype thyroid cancer: A surveillance, epidemiology, and end results database analysis.
    Oncotarget 2017 Oct 23;8(49):86556-86565. Epub 2017 Sep 23.
    Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.
    The prognosis of patients with mixed subtype thyroid cancer (MSTC) is unclear. The present study compared the prognoses of MSTC, papillary thyroid cancer (PTC), and follicular thyroid cancer (FTC) to provide a new perspective regarding the treatment guidelines for these diseases. We evaluated data from patients with thyroid cancer who were included in the Surveillance, Epidemiology, and End Results database between 2004 and 2013. Read More

    Somatic mutations in CDH1 and CTNNB1 in primary carcinomas at 13 anatomic sites.
    Oncotarget 2017 Oct 21;8(49):85680-85691. Epub 2017 Sep 21.
    Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
    Metastases are involved in most cancer deaths. Evidence has suggested that cancer cell detachment from primary tumors might occur largely via the mechanism of epithelial-mesenchymal transition (EMT) activated by epigenetic events, but data addressing other possible triggers of detachment, particularly genetic mutations, have been limited. Using the Profile study of cancer genomics at Dana-Farber Cancer Institute, we examined somatic mutations in the EMT genes CDH1 in 5,106 primary carcinomas and CTNNB1 in 7,578 primary carcinomas across 13 anatomic sites: urinary bladder, breast, colon/rectum, endometrium, esophagus, kidney, lung, ovary, pancreas, prostate, skin (non-melanoma), stomach, and thyroid. Read More

    Advances in applied homeostatic modelling of the relationship between thyrotropin and free thyroxine.
    PLoS One 2017 20;12(11):e0187232. Epub 2017 Nov 20.
    Medical Department I, Endocrinology and Diabetology, Bergmannsheil University Hospitals, Ruhr University of Bochum, Bochum, Germany.
    Introduction: The relationship between pituitary TSH and thyroid hormones is central to our understanding of thyroid physiology and thyroid function testing. Here, we generated distribution patterns by using validated tools of thyroid modelling.

    Methods: We simulated patterns of individual set points under various conditions, based on a homeostatic model of thyroid feedback control. Read More

    Long-term cardiovascular morbidity and mortality in patients treated for differentiated thyroid cancer.
    Clin Endocrinol (Oxf) 2017 Nov 20. Epub 2017 Nov 20.
    Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
    Objective: Thyroid hormone suppression therapy has been widely used in the treatment of thyroid cancer, but concerns have been raised about the cardiovascular risks of this treatment. The objective of this study was to evaluate long-term cardiovascular morbidity and mortality in patients treated for differentiated thyroid cancer (DTC) and to assess the effect of TSH suppression and radioiodine (RAI) treatment on the cardiovascular outcome.

    Design: Retrospective cohort study. Read More

    Sonographic Criteria Predictive of Malignant Thyroid Nodules: Which Lesions Should be Biopsied?
    Acad Radiol 2017 Nov 16. Epub 2017 Nov 16.
    Serviço de Radiologia, Hospitais da Universidade de Coimbra Praceta Mota Pinto, 3000-075 Coimbra, Portugal.
    Rationale And Objectives: The objective of this study was to evaluate the ultrasound features of thyroid nodules and their association with malignancy, focusing on establishing feature-oriented ultrasound criteria to determine proper management of a thyroid nodule.

    Materials And Methods: A sample of 379 thyroid nodules were biopsied (from a total of 357 patients aged 59.8 ± 14. Read More

    Integrating surgery and genetic testing for the modern surgeon.
    Ann Transl Med 2017 Oct;5(20):399
    Department of Surgery, MedStar Georgetown University Hospital, Washington, DC, USA.
    The field of cancer genetics is rapidly evolving and several genetic mutations have been identified in hereditary cancer syndromes. These mutations can be diagnosed via routine genetic testing allowing prompt intervention. This is especially true for certain variants of colorectal, breast, and thyroid cancers where genetic testing may guide surgical therapy. Read More

    A Low-Normal Free Triiodothyronine Level Is Associated with Adverse Prognosis in Euthyroid Patients with Heart Failure Receiving Cardiac Resynchronization Therapy.
    Int Heart J 2017 Nov 17. Epub 2017 Nov 17.
    Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University.
    Thyroid dysfunction is prevalent in patients with heart failure (HF) and hypothyroidism is related to the adverse prognosis of HF subjects receiving cardiac resynchronization therapy (CRT). We aim to investigate whether low-normal free triiodothyronine (fT3) level is related to CRT response and the prognosis of euthyroid patients with HF after CRT implantation.One hundred and thirteen euthyroid patients who received CRT therapy without previous thyroid disease and any treatment affecting thyroid hormones were enrolled. Read More

    Thyroid malignancy risk in different clinical thyroid diseases
    Turk J Med Sci 2017 11 13;47(5):1509-1519. Epub 2017 Nov 13.
    Background/aim: To evaluate the malignancy risk of thyroid nodules in different clinical thyroid diseases. Materials and methods: Patients who underwent thyroidectomy between 2007 and 2014 were grouped as euthyroid, hypothyroid, and hyperthyroid. Further classification was made depending on the presence of solitary/multiple thyroid nodules. Read More

    Eleven patients with primary thyroid lymphoma: a single center experience
    Turk J Med Sci 2017 11 13;47(5):1322-1327. Epub 2017 Nov 13.
    Background/aim: Primary thyroid lymphoma (PTL) is a very rare thyroid malignancy. It should be diagnosed and treated immediately and accurately. Our aim was to evaluate the diagnostic methods and treatment results for patients with PTL. Read More

    [Analysis of Incidence and Mortality of Thyroid Cancer in China, 2013].
    Zhonghua Zhong Liu Za Zhi 2017 Nov;39(11):862-867
    Department of Thoracic Surgery, National Cancer Centre/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
    Objective: To evaluate the incidence and mortality status of thyroid cancer in China, 2013. Methods: Incidence and mortality data of thyroid cancer were derived from 255 population-based cancer registries in China. Age-specific and age standardized incidence and mortality rates of thyroid cancer in different areas (urban and rural) with different gender were calculated based on the stratification of area (urban and rural), gender, age and tumor position. Read More

    Survey on Paediatric Differentiated Thyroid Cancer Care in Europe.
    Horm Res Paediatr 2017 Nov 17. Epub 2017 Nov 17.
    Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
    Background/aims: Thyroid cancer among children is a very rare disease. Although survival is favourable, morbidity caused by the treatment remains considerable, so there is a great need to optimize management by international cooperation. For this reason, the 2016 European Thyroid Association-Cancer Research Network (ETA-CRN) meeting in Copenhagen, Denmark, paid considerable attention to this topic and aimed to give an overview of the care for this paediatric patient group in different European countries. Read More

    Polymorphism T81C in H-RAS Oncogene Is Associated With Disease Progression in Imatinib (TKI) Treated Chronic Myeloid Leukemia Patients.
    World J Oncol 2015 Apr 12;6(2):321-328. Epub 2015 Apr 12.
    Cancer Genetics Lab, Department of Biochemistry and Associated Hospitals, New Delhi, India.
    Background: Mammalian cells contain three functional RAS proto-oncogenes, known as H-RAS, K-RAS, and N-RAS, which encode small GTP-binding proteins in terms of p21(ras)s. RAS genes have been elucidated as major participants in the development and progression of cancer. A single nucleotide polymorphism (SNP) at H-RAS cDNA position 81 T→C (rs12628) has been found to be associated with the risk of many human cancers like gastrointestinal, oral, colon, bladder and thyroid carcinomas. Read More

    Metastatic Medullary Thyroid Carcinoma and Cabozantinib: Case Series and Review of Literature.
    World J Oncol 2014 Apr 6;5(2):81-89. Epub 2014 May 6.
    Division of Pathology, Overlook Medical Center, 99 Beauvoir Ave, Summit, NJ 07902, USA.
    Cabozantinib, a tyrosine kinase inhibitor, was approved by the US Food and Drug Administration in November 2012, for the treatment of metastatic medullary thyroid carcinoma. Although side effects typically include stomatitis, palmar-plantar erythrodysesthesia syndrome, hypertension and diarrhea, most patients are able to tolerate the recommended dose of 140 mg daily. Surgical resection is the primary treatment for medullary thyroid carcinoma. Read More

    Advanced Thyroid Cancer Patients in Phase I Clinical Trials: Outcome Assessment and Literature Review.
    World J Oncol 2014 Feb 11;5(1):24-32. Epub 2014 Mar 11.
    Institute for Drug Development (IDD), Cancer Therapy and Research Center (CTRC), University of Texas Health Science Center, San Antonio, TX, USA.
    Background: To describe the basic demographics, analyze the response and survival experience of advanced thyroid cancer subjects treated in Phase I clinical trials. We also reviewed early Phase studies using new targeted agents in thyroid cancer.

    Methods: We conducted a retrospective observational study in 32 advanced thyroid cancer patients who participated in 21 Phase I trials at our center between 2002 and 2012. Read More

    Distribution of Thyroid Cancer in the Eastern Part of Turkey 27 Years After the Chernobyl Accident.
    World J Oncol 2013 Dec 16;4(6):230-234. Epub 2014 Jan 16.
    Department of Nephrology, Recep Tayyip Erdogan University, Rize, Turkey.
    Background: The Chernobyl accident caused widespread effects across Europe and huge areas where radiocontaminated. The effects of the Chernobyl accident on thyroid cancer have been investigated in most European countries. According to the data of the Turkish Atomic Energy Authority, the eastern part of the Black Sea region was the most radiocontaminated area in Turkey at the time of Chernobyl accident. Read More

    A Rare but Significant Cause of an Enlarging Neck Mass: A Case Report of Primary Thyroid Lymphoma.
    World J Oncol 2013 Jun 15;4(3):158-160. Epub 2013 Jul 15.
    Division of Endocrinology, Metabolism, and Lipid Research, Washington University in Saint Louis, USA.
    Primary thyroid lymphoma is a rare form of non-Hodgkin's lymphoma that typically presents as a rapidly enlarging goiter in patients with a history of autoimmune thyroid disease. We present the evaluation, pitfalls in diagnosis, and treatment of a 49-year-old woman with diffuse large B-cell primary thyroid lymphoma presenting with airway obstruction. Read More

    Angiogenesis in Malignant Thyroid Tumors.
    World J Oncol 2010 Dec 1;1(6):221-231. Epub 2011 Jan 1.
    United Institute of Informatics Problems, National Academy of Sciences of Belarus, Minsk. Belarus, 220040, Minsk, Bogdanovicha lane, 112/38. Email:
    It is well known that radiation significantly impacts the morbidity of thyroid cancer and that is why Belarus has the highest incidence of the malignancy. Author describes statistical data, classification of angiogenesis, and typical pathological features of malignant thyroid diseases with regard to the vascular network. Read More

    Population analysis of predictors of difficult intubation with direct laryngoscopy in pediatric patients with and without thyroid disease.
    J Anesth 2017 Nov 17. Epub 2017 Nov 17.
    Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.
    Purpose: There are no data on the prevalence and predictors of difficult intubation (DI) in pediatric patients with thyroid disease. This study (1) assesses the prevalence of DI in patients with thyroid disease undergoing elective operations, (2) identifies other predictors of DI in children, and (3) evaluates the effect of DI on postoperative care and length-of-stay.

    Methods: A single-center retrospective cohort analysis of procedures in patients assigned with an ICD-9 code for thyroid disease between June 2012 and February 2016. Read More

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