171,700 results match your criteria Thyroid Disease


Preoperative Potassium Iodide Treatment in Patients Undergoing Thyroidectomy for Graves' Disease-Perspective of a European High-Volume Center.

World J Surg 2020 May 23. Epub 2020 May 23.

Department of Endocrine Surgery, Schoen Clinic, Dehnhaide 120, 22081, Hamburg, Germany.

Background: Potassium iodide (KI) treatment affects the vascularity of the thyroid gland and therefore may improve intraoperative visualization of essential structures. However, clear evidence for its usage is lacking, and its implementation in patients suffering from Graves' disease is becoming rare. The objective of this retrospective study was to assess the impact of KI treatment on the intraoperative course and the outcome of patients undergoing thyroidectomy for Graves' diseases. Read More

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http://dx.doi.org/10.1007/s00268-020-05593-0DOI Listing

Medical treatment in thyroid eye disease in 2020.

Br J Ophthalmol 2020 May 23. Epub 2020 May 23.

Department of Surgery, University of Melbourne, Centre for Eye Research Australia Ltd, East Melbourne, Victoria, Australia.

Thyroid eye disease (TED) affects 25% of patients with Graves' hyperthyroidism, where 1 in 20 patients has active, moderate-to-severe disease that will require medical treatment for reducing TED activity and severity. Intravenous corticosteroid has been the mainstay of treatment for active moderate-to-severe TED. With improved understanding of the pathophysiology of TED, immunotherapy targeting different molecular pathways including T cells, B cells, cytokines and cell surface receptors have been investigated in randomised clinical trials. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316051DOI Listing

Evaluation of the performance of ultrasonography and 99mTc-sestamibi scintigraphy for primary hyperparathyroidism surgery.

Eur Ann Otorhinolaryngol Head Neck Dis 2020 May 20. Epub 2020 May 20.

Service d'ORL et de Chirurgie Cervico-Faciale, CHU Brest, Brest, France.

Introduction: Minimally invasive surgery has become the standard surgical attitude in primary hyperparathyroidism. It requires precise preoperative lesion localization. The aim of the present study was to evaluate the performance of ultrasonography and 99mTc-sestamibi scintigraphy in minimally invasive surgery for primary hyperparathyroidism. Read More

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http://dx.doi.org/10.1016/j.anorl.2020.03.009DOI Listing

Thyroid hormones ratio is a major prognostic marker in advanced metastatic colorectal cancer: Results from the phase III randomised CORRECT trial.

Eur J Cancer 2020 May 20;133:66-73. Epub 2020 May 20.

Department of Oncology, Unit of Oncology 1, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy. Electronic address:

Background: Free triiodothyronine (FT3)/free thyroxine (FT4) ratio is an index estimating the peripheral activity of thyroid hormones. In a previous experience, we identified a prognostic role for FT3/FT4 ratio in chemorefractory patients treated with regorafenib. Therefore, we planned this post hoc analysis of the phase III CORRECT trial of regorafenib versus placebo. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.04.023DOI Listing

Treatment Variation in Older Adults With Differentiated Thyroid Cancer.

J Surg Res 2020 May 20;254:154-164. Epub 2020 May 20.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

Background: The growth of the aging population coupled with the increasing incidence of thyroid cancer warrants a better understanding of thyroid cancer in older adults. We aimed to investigate the variation of treatment patterns and determine if the extent of surgery is associated with disease-specific mortality in older adults with differentiated thyroid cancer (DTC).

Methods: We performed a population-based study using the Surveillance, Epidemiology, and End Results 18 program to examine patients diagnosed with DTC between 2004 and 2015. Read More

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http://dx.doi.org/10.1016/j.jss.2020.04.013DOI Listing

Association of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis.

Lancet Diabetes Endocrinol 2020 Jun;8(6):501-510

Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands; Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, Netherlands. Electronic address:

Background: Adequate transplacental passage of maternal thyroid hormone is important for normal fetal growth and development. Maternal overt hypothyroidism and hyperthyroidism are associated with low birthweight, but important knowledge gaps remain regarding the effect of subclinical thyroid function test abnormalities on birthweight-both in general and during the late second and third trimester of pregnancy. The aim of this study was to examine associations of maternal thyroid function with birthweight. Read More

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http://dx.doi.org/10.1016/S2213-8587(20)30061-9DOI Listing

Histopathologic Features and Clinical Outcome of Anaplastic Thyroid Carcinoma with a Minor Anaplastic Component.

Endocr Pathol 2020 May 22. Epub 2020 May 22.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Although prior studies have reported that patients with anaplastic thyroid carcinoma (ATC) with a focal anaplastic component may have a prolonged survival compared to other ATC patients, the outcome data are limited. We evaluated a cohort of ATC resected between 2003 and 2018. Tumor slides were reviewed to confirm the diagnosis and to identify cases with a minor ATC component (defined as comprising < 10% of the tumor). Read More

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http://dx.doi.org/10.1007/s12022-020-09627-0DOI Listing

Thyrotoxic Periodic Paralysis-A Misleading Challenge in the Emergency Department.

Diagnostics (Basel) 2020 May 18;10(5). Epub 2020 May 18.

Endocrinology Department, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, 700111 Iasi, Romania.

Despite its' life-threatening potential due to cardiac severe dysrhythmia in the context of severe hypokalemia, thyrotoxic periodic paralysis (TPP) often goes unrecognized. Although classically confined to young Asian men, it can occur irrespective of age, sex, and race. We report a short series of three cases of TPP as first presentation of Graves' disease in a young Caucasian male and in two Caucasian elderly and middle-aged women, respectively. Read More

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http://dx.doi.org/10.3390/diagnostics10050316DOI Listing

Clinical and prognostic value of neutrophil-lymphocyte ratio for patients with thyroid cancer: A meta-analysis.

Medicine (Baltimore) 2020 May;99(20):e19686

College of Basic Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, China.

Background: Although the malignant degree is relatively low and overall prognosis is excellent, some patients with thyroid cancer still experience metastasis during the follow-up, which leads to their possible death. Pretreatment neutrophil-to-lymphocyte ratio (NLR) has been recommended as a biomarker for the prediction of metastasis and prognosis in patients with cancers. However, its value in thyroid cancer remains inconclusive. Read More

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http://dx.doi.org/10.1097/MD.0000000000019686DOI Listing

Thyroid Disease in Pregnancy: ACOG Practice Bulletin, Number 223.

Authors:

Obstet Gynecol 2020 Jun;135(6):e261-e274

Both thyrotoxicosis and hypothyroidism are associated with adverse pregnancy outcomes. There also is concern about the effect of overt maternal thyroid disease on fetal development. In addition, medications that affect the maternal thyroid gland can cross the placenta and affect the fetal thyroid gland. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003893DOI Listing

Thyroid Disease in Pregnancy: ACOG Practice Bulletin Summary, Number 223.

Authors:

Obstet Gynecol 2020 Jun;135(6):1496-1499

Both thyrotoxicosis and hypothyroidism are associated with adverse pregnancy outcomes. There also is concern about the effect of overt maternal thyroid disease on fetal development. In addition, medications that affect the maternal thyroid gland can cross the placenta and affect the fetal thyroid gland. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003894DOI Listing

[Hypoparathyroidism treated with recombinant human parathyroid hormone [rhPTH(1-84)]].

Medicina (B Aires) 2020 ;80(3):289-291

Servicio de Endocrinología, Clínica Universitaria Reina Fabiola, Córdoba, Argentina.

Hypoparathyroidism (HypoPT) is a rare disease characterized by low calcium and inappropriately low circulating parathormone levels. We present the case of a 25-year-old high-performance athlete male, with history of HypoPT after total thyroidectomy for papillary thyroid carcinoma (T3 N1b M0) two years before, who was referred to our clinic for symptomatic hypocalcemia. The patient reported serum calcium average levels of 7mg%, presented symptoms of hypocalcemia at rest and had multiple hospital admissions. Read More

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January 2020

Experimental evidence for alpha enolase as one potential autoantigen in the pathogenesis of both autoimmune thyroiditis and its related encephalopathy.

Int Immunopharmacol 2020 May 19;85:106563. Epub 2020 May 19.

Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang 110001, PR China.

Alpha-enolase (ENO1) is a ubiquitous protein. Patients with autoimmune thyroiditis-associated encephalopathy have high serum ENO1Ab titers. We aimed to explore whether ENO1Ab was the pathogenic antibody in the thyroid and brain. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106563DOI Listing

Stroke in the patient with diabetes (Part 1) - Epidemiology, etiology, therapy and prognosis.

Diabetes Res Clin Pract 2020 May 19:108193. Epub 2020 May 19.

Southside Endocrinology, Diabetes and Thyroid Associates, Birmingham, AL. Electronic address:

There is a higher incidence of stroke in both the type 2 diabetic and the non-diabetic insulin resistant patient which is accompanied by higher morbidity and mortality. The increase in the frequency of stroke is due to an increase in cerebral infarction, mainly lacunar infarcts, with the incidence of cerebral hemorrhage being less frequent. The major risk factors for stroke in the type 2 diabetic patient are age, hypertension, the number of features of the Metabolic Syndrome, the presence of diabetic nephropathy in both the type 1 and type 2 patient, the presence of peripheral and coronary artery disease and especially the presence of atrial fibrillation. Read More

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http://dx.doi.org/10.1016/j.diabres.2020.108193DOI Listing

FUT7 promotes the malignant transformation of follicular thyroid carcinoma through α1,3-Fucosylation of EGF receptor.

Exp Cell Res 2020 May 19:112095. Epub 2020 May 19.

Department of Pathology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China. Electronic address:

Aberrant protein glycosylation is involved in many diseases including cancer. This study investigated the role of fulcosytransferase VII (FUT7) in the progression of follicular thyroid carcinoma (FTC). FUT7 expression was found to be upregulated in FTC compared to paracancerous thyroid tissue, and in FTC with T2 stage of TMN classification compared to FTC with T1 stage. Read More

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http://dx.doi.org/10.1016/j.yexcr.2020.112095DOI Listing

Clinical Assessment of Pediatric Patients with Differentiated Thyroid Carcinoma: A 30-Year Experience at a Single Institution.

World J Surg 2020 May 21. Epub 2020 May 21.

Department of Surgery, Yonsei University College of Medicine, Seoul, 03722, Korea.

Background: Thyroidectomy is the typical treatment for pediatric thyroid carcinoma; total thyroidectomy is commonly performed. We aimed to report our experience at a single tertiary institution and to evaluate the risk factors for recurrence, especially based on surgical extent, in pediatric patients with differentiated thyroid carcinoma (DTC).

Methods: A data of 94 pediatric patients who underwent thyroid surgery for DTC from January 1982 to December 2012 at Yonsei University Hospital (Seoul, Korea) were reviewed. Read More

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http://dx.doi.org/10.1007/s00268-020-05598-9DOI Listing

Influence of Body Mass Index on Survival and Prognosis in Squamous Cell Carcinoma of Head and Neck.

Cancer Manag Res 2020 7;12:3203-3210. Epub 2020 May 7.

Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.

Objective: Differences in body mass index (BMI) were used to analyze the survival and prognosis of SCCHN patients.

Patients And Methods: A retrospective cohort study was conducted to select 323 patients who underwent surgical treatment for SCCHN from June 2013 to June 2016. The patients were divided into a healthy BMI group (BMI<24kg/m), an overweight group (24kg/m≤BMI<28kg/m) and an obese group (BMI≥28 kg/m). Read More

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http://dx.doi.org/10.2147/CMAR.S249775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221410PMC

FoxO1-Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth.

Nat Commun 2020 May 21;11(1):2551. Epub 2020 May 21.

Department of Internal Medicine (Cardiology Division), University of Texas Southwestern Medical Center, Dallas, TX, 75390-8573, USA.

Forkhead box O (FoxO) proteins and thyroid hormone (TH) have well established roles in cardiovascular morphogenesis and remodeling. However, specific role(s) of individual FoxO family members in stress-induced growth and remodeling of cardiomyocytes remains unknown. Here, we report that FoxO1, but not FoxO3, activity is essential for reciprocal regulation of types II and III iodothyronine deiodinases (Dio2 and Dio3, respectively), key enzymes involved in intracellular TH metabolism. Read More

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http://dx.doi.org/10.1038/s41467-020-16345-yDOI Listing

The aryl hydrocarbon receptor pathway controls matrix metalloproteinase-1 and collagen levels in human orbital fibroblasts.

Sci Rep 2020 May 21;10(1):8477. Epub 2020 May 21.

Flaum Eye Institute, University of Rochester, Rochester, New York, 14642, USA.

Thyroid eye disease (TED) affects 25-50% of patients with Graves' Disease. In TED, collagen accumulation leads to an expansion of the extracellular matrix (ECM) which causes destructive tissue remodeling. The purpose of this study was to investigate the therapeutic potential of activating the aryl hydrocarbon receptor (AHR) to limit ECM accumulation in vitro. Read More

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http://dx.doi.org/10.1038/s41598-020-65414-1DOI Listing

Relationship between thyroid hormone levels and the pathology of Alzheimer's disease in euthyroid subjects.

Thyroid 2020 May 22. Epub 2020 May 22.

Keimyung University School of Medicine, 37976, Nuclear Medicine, Daegu, Korea (the Republic of);

Background: Although several studies have reported an association between thyroid dysfunction and Alzheimer's disease (AD), the effect of mild thyroid dysfunction within the normal range of TSH on the development of AD remains unclear. The aim of this study was to evaluate the association between thyroid hormones and the pathology of AD in euthyroid subjects.

Methods: Sixty-nine subjects with a TSH level between 0. Read More

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http://dx.doi.org/10.1089/thy.2019.0727DOI Listing

Endocrinology in the time of COVID-19: Management of hyper- and hypo- thyroidism.

Eur J Endocrinol 2020 May 1. Epub 2020 May 1.

L Persani, IRCCS Istituto Auxologico Italiano, Universita degli Studi di Milano Dipartimento di Scienze Cliniche e di Comunita, Milano, 20149, Italy.

This manuscript provides guidance on the management of thyroid dysfunction during the COVID-19 pandemic. Auto-immune thyroid diseases are not linked to increased risks of COVID-19. Uncontrolled thyrotoxicosis may result in more severe complications from SARS-CoV-2 infection, including thyroid storm. Read More

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http://dx.doi.org/10.1530/EJE-20-0445DOI Listing

Upregulation of LAGE3 correlates with prognosis and immune infiltrates in colorectal cancer: A bioinformatic analysis.

Int Immunopharmacol 2020 May 18;85:106599. Epub 2020 May 18.

Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, #1 Nan Bai Xiang Street, Wenzhou 325006, China. Electronic address:

Background: Colorectal cancer (CRC) is the primary cause of cancer-related deaths worldwide. Identification of new CRC biomarkers is imperative to improve the prognosis and development of therapies against the disease. LAGE3 (L Antigen Family Member 3) functions as a tRNA modifier, although its potential role in CRC has not been fully elucidated. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106599DOI Listing

Treatment Discontinuation within 3 Years of Levothyroxine Initiation among Children Diagnosed with Congenital Hypothyroidism.

J Pediatr 2020 May 8. Epub 2020 May 8.

National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA.

Objectives: To measure the rates of thyroid gland imaging and levothyroxine (L-T discontinuation and to assess whether discontinuation was monitored with thyroid stimulating hormone (TSH) testing in subjects with congenital hypothyroidism.

Study Design: This is a retrospective analysis of claims data from the IBM MarketScan Databases for children born during 2010-2016 and continuously enrolled in a non-capitated employer-sponsored private health insurance plan or in Medicaid for ≥36 months from the date of the first filled L-T prescription.

Results: 263 privately-insured and 241 Medicaid-enrolled children met the inclusion criteria. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.05.005DOI Listing

Thyroid cancer risk factors and Pakistani University students' awareness towards its preventive practice.

J Oncol Pharm Pract 2020 May 21:1078155220925166. Epub 2020 May 21.

Department of Pharmacy, COMSATS University Islamabad, Lahore, Pakistan.

Objectives: Thyroid Cancer is one of the rarest cancers but its prevalence has been increasing worldwide for the last couple of decades.

Methods: The data collection tool was designed to assess knowledge, awareness, perception, and attitude towards preventive practices of thyroid cancer in Pakistani university students. The data were collected over a duration of six months and a total number of 3722 students participated. Read More

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http://dx.doi.org/10.1177/1078155220925166DOI Listing

Endocrine surgery in the Coronavirus disease 2019 pandemic: Surgical Triage Guidelines.

Head Neck 2020 Apr 16. Epub 2020 Apr 16.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background: In the face of the COVID-19 pandemic, cancer care has had to adapt rapidly given the Centers for Disease Control and Prevention and the American College of Surgeons (ACS) issuing recommendations to postpone nonurgent surgeries.

Methods: An institutional multidisciplinary group of Head and Neck Surgical Oncology, Surgical Endocrinology, and Medical Endocrinology devised Surgical Triaging Guidelines for Endocrine Surgery during COVID-19, aligned with phases of care published by the ACS.

Results: Phases of care with examples of corresponding endocrine cases are outlined. Read More

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http://dx.doi.org/10.1002/hed.26169DOI Listing

Chromogranin Serves as Novel Biomarker of Endocrine and Gastric Autoimmunity.

J Clin Endocrinol Metab 2020 May 21. Epub 2020 May 21.

Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany.

Context: The glycoprotein Chromogranin A (CgA) is expressed by endocrine and neuroendocrine cells. High levels of serum CgA serve as marker of neuroendocrine tumors (NET), but its role in autoimmunity has not been assessed.

Objective: Investigate CgA utility as marker of endocrine autoimmunity. Read More

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http://dx.doi.org/10.1210/clinem/dgaa288DOI Listing

Subacute thyroiditis after SARS-CoV-2 infection.

J Clin Endocrinol Metab 2020 May 21. Epub 2020 May 21.

Endocrinology Unit I, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy.

Context: Subacute thyroiditis (SAT) is a thyroid disease of viral or post-viral origin. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that began in Wuhan, China, has spread rapidly worldwide and Italy has been severely affected by this outbreak.

Objectives: To report the first case of SAT related to SARS-CoV-2 infection. Read More

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http://dx.doi.org/10.1210/clinem/dgaa276DOI Listing

Autoimmune Thyroid Diseases after 25 years of Universal Salt Iodization: An Epidemiologic Study of Chinese Adults in Areas with Different Water Iodine Levels.

Br J Nutr 2020 May 21:1-30. Epub 2020 May 21.

Centre for Endemic Disease Control, Chinese Centre for Disease Control and Prevention, Harbin Medical University, Harbin City, Heilongjiang Province 150081, People's Republic of China.

The present study aimed to evaluate the status of iodine nutrition and thyroid function in adults, to understand the distribution of thyroid disease in people with autoimmune thyroid disease (AITD) in different water iodine areas, and to explore the relationship between serum iodine, urine iodine and thyroid function in people with AITD. A cross-sectional survey was conducted in areas of Shandong Province with different water iodine levels and subsequently 1225 adults were enrolled from I-deficient (ID), I-adequate (IA), and I-excess (IE) areas. Urinary iodine, water iodine, salt iodine, serum iodine, thyroid function were measured. Read More

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http://dx.doi.org/10.1017/S0007114520001786DOI Listing

Lithium's antiviral effects: a potential drug for CoViD-19 disease?

Int J Bipolar Disord 2020 May 20;8(1):21. Epub 2020 May 20.

Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.

Background: Since its introduction in modern medicine, naturalistic observations emerged about possible uses of lithium treatment for conditions different from recurring affective disorders, for which it is still a first-line treatment option. Some evidence about the antiviral properties of lithium began in the early 1970s, when some reports found a reduction of labial-herpetic recurrences. The present review aims to present most of the pre-clinical and clinical evidence about lithium's ability to inhibit DNA and RNA viruses, including Coronaviridae, as well as the possible pathways and mechanisms involved in such antiviral activity. Read More

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http://dx.doi.org/10.1186/s40345-020-00191-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239605PMC

Tumor-associated tissue eosinophilia predicts favorable clinical outcome in solid tumors: a meta-analysis.

BMC Cancer 2020 May 20;20(1):454. Epub 2020 May 20.

Department of Gynecology, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310009, China.

Background: Activated eosinophils have been deemed to affect carcinogenesis and tumor progression via various mechanisms in tumor microenvironment. However, the prognostic role of tumor-associated tissue eosinophilia (TATE) in human cancers remains controversial. Therefore, we conducted this meta-analysis to better comprehend the association between TATE and clinical outcomes of patients. Read More

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http://dx.doi.org/10.1186/s12885-020-06966-3DOI Listing

Familial Cerebral Cavernous Malformation Syndrome with Concomitant Fourth Ventricular Ependymoma: True Association or Mere Coincidence?

Cancer Genet 2020 May 3;244:36-39. Epub 2020 May 3.

Department of Neurological Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA. Electronic address:

Familial cerebral cavernous malformation syndromes are most commonly caused by mutations in one of three genes. The overlap of these genetic malformations with other acquired neoplastic lesions and congenital malformations is still under investigation. To the best of our knowledge, the concurrent occurrence of familial cavernous malformations and ependymoma has not been previously reported in the literature. Read More

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http://dx.doi.org/10.1016/j.cancergen.2020.04.075DOI Listing

Effect of Different 131I Dose Strategies for Treatment of Hyperthyroidism on Graves' Ophthalmopathy.

Clin Nucl Med 2020 May 19. Epub 2020 May 19.

From the Nuclear Medicine Research Center.

Purpose: The study aims to define the effect of different dose strategies on ophthalmic complications in patients with Graves' disease (GD).

Methods: All the patients with GD and no or inactive ophthalmopathy (clinical activity score; CAS < 3) underwent Snellen chart examination, measurement of proptosis, thyroid volume, and radioactive iodine uptake, and randomized into 1 of 3 groups. In group 1, all the patients received fixed low dose (FLD) of 259 MBq of I, whereas in group 2, all the patients received fixed high dose (FHD) of 555 MBq, and in group 3, calculated dose (CD) was administered to deliver 5. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003086DOI Listing

Microarray profile of B cells from Graves' disease patients reveals biomarkers of proliferation.

Endocr Connect 2020 May 1;9(5):405-417. Epub 2020 May 1.

Department of Endocrinology, Fifth People's Hospital of Shanghai Fudan University, Shanghai, China.

B lymphocytes are the source of autoantibodies against the thyroid-stimulating hormone receptor (TSHR) in Graves' disease (GD). Characterization of autoimmune B-cell expression profiles might enable a better understanding of GD pathogenesis. To reveal this, the expression levels of long noncoding RNAs (lncRNAs) and mRNAs (genes) in purified B cells from patients with newly diagnosed GD and healthy individuals were compared using microarrays, which elucidated 604 differentially expressed lncRNAs (DE-lncRNAs) and 410 differentially expressed genes (DEGs). Read More

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http://dx.doi.org/10.1530/EC-20-0045DOI Listing

Subclinical thyroid dysfunction in 1st trimester of pregnancy: "disease" versus physiological (pulsatile) variation in TSH concentrations.

Clin Endocrinol (Oxf) 2020 May 19. Epub 2020 May 19.

Polish Mothers' Memorial Hospital - Research Institute, Department of Endocrinology and Metabolic Diseases, Lodz, Poland.

Background: There is no universal consensus regarding cut off points for TSH in pregnancy, so concentrations of 2.5 mIU/L or 4.0 mIU/L were suggested for 1 trimester (Endocrine Society (2012) and ATA (2017) guidelines, respectively). Read More

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http://dx.doi.org/10.1111/cen.14256DOI Listing

Development and validation of a web-based malignancy risk-stratification system of thyroid nodules.

Clin Endocrinol (Oxf) 2020 May 19. Epub 2020 May 19.

Department of Radiology, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, P.R. China.

Objectives: Previous publications on risk-stratification systems for malignant thyroid nodules were based on conventional ultrasound only. We aimed to develop a practical and simplified prediction model for categorizing the malignancy risk of thyroid nodules based on clinical data, biochemical data, conventional ultrasound and real-time elastography.

Design: Retrospective cohort study. Read More

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http://dx.doi.org/10.1111/cen.14255DOI Listing

The effects of patient and disease-related factors on the quality of life in patients with hypoparathyroidism.

Arch Osteoporos 2020 May 19;15(1):75. Epub 2020 May 19.

Department of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.

This study aims to evaluate factors affecting the quality of life (QOL) of hypoparathyroidism. While QOL is reduced in post-surgical and non-surgical groups, mental health seems to be less affected in non-surgical patients. Having an additional disease affects QOL negatively but having thyroid cancer may not change the QOL results. Read More

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http://dx.doi.org/10.1007/s11657-020-00759-8DOI Listing

Ovarian Sertoli-Leydig cell tumors: an analysis of 13 cases.

Arch Gynecol Obstet 2020 May 19. Epub 2020 May 19.

International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Purpose: To report the clinical, ultrasound and histopathological characteristics, clinical management, and prognosis of 13 patients with Sertoli-Leydig cell tumors (SLCTs) of ovary.

Methods: 13 patients with pathologically confirmed ovarian SLCTs at International Peace Maternity and Child Health Hospital from 2010 and 2019 were included in this study. The clinical, ultrasound and histopathological characteristics, clinical management, and prognosis of 13 patients were retrospectively analyzed. Read More

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http://dx.doi.org/10.1007/s00404-020-05588-1DOI Listing

ALK-1-positive inflammatory myofibroblastic tumor of the thyroid complicated by Hashimoto's thyroiditis: report of a rare case and a literature review.

Diagn Pathol 2020 May 19;15(1):58. Epub 2020 May 19.

Department of Pathology, the Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, Guizhou, China.

Background: Inflammatory myofibroblastic tumors (IMTs) of the thyroid are extremely rare soft-tissue tumors. In the literature, IMTs are sometimes called plasma cell granulomas (PCGs) or inflammatory pseudotumors, which often causes ambiguity. To date, 17 cases of PCGs and five cases of thyroid IMTs have been reported. Read More

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http://dx.doi.org/10.1186/s13000-020-00966-4DOI Listing

Teprotumumab: a novel therapeutic monoclonal antibody for thyroid-associated ophthalmopathy.

Expert Opin Investig Drugs 2020 May 19. Epub 2020 May 19.

Department of Ophthalmology and Visual Sciences, W. K Kellogg Eye Center, University of Michigan Medical School, 1000 Wall St, Ann Arbor, MI 48105, USA.

: Thyroid-associated ophthalmopathy (TAO) is a disfiguring, potentially blinding, and sub-optimally managed autoimmune condition. Current therapy of active TAO consists most frequently of glucocorticoid steroids, orbital radiation, or B-cell depletion; all of which are associated with substantial side effects. Teprotumumab (Tepezza) is a human monoclonal antibody against the insulin-like growth factor type I receptor (IGF-IR), recently evaluated in 2 clinical trials for active moderate-to-severe TAO that was recently approved by the United States Food and Drug Administration (FDA) for use in TAO. Read More

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http://dx.doi.org/10.1080/13543784.2020.1772752DOI Listing

Immunomodulatory Effects of Vitamin D in Thyroid Diseases.

Nutrients 2020 May 16;12(5). Epub 2020 May 16.

Department of Translational Medicine, University of Piemonte Orientale UPO, 28100 Novara, Italy.

Vitamin D is a secosteroid with a pleiotropic role in multiple physiological processes. Besides the well-known activity on bone homeostasis, recent studies suggested a peculiar role of vitamin D in different non-skeletal pathways, including a key role in the modulation of immune responses. Recent evidences demonstrated that vitamin D acts on innate and adaptative immunity and seems to exert an immunomodulating action on autoimmune diseases and cancers. Read More

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http://dx.doi.org/10.3390/nu12051444DOI Listing

Response Rate and Prognostic Impact of Salvage Chemotherapy after Nivolumab in Patients with Advanced Gastric Cancer.

Oncology 2020 May 19:1-7. Epub 2020 May 19.

Department of Onco-biological Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Objective: Nivolumab is recommended as a third-line treatment in patients with unresectable advanced or recurrent gastric cancer. Although recent studies have demonstrated the prognostic impact of salvage chemotherapy after immune checkpoint inhibitors in several malignancies, its clinical significance remains unclear in patients with gastric cancer. This study aimed to investigate tumor response to subsequent chemotherapy after nivolumab in patients with advanced gastric cancer and assess the prognostic effect of salvage chemotherapy. Read More

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http://dx.doi.org/10.1159/000507219DOI Listing

Non-coding RNAs in drug resistance of head and neck cancers: A review.

Biomed Pharmacother 2020 May 16;127:110231. Epub 2020 May 16.

Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Shanxi Medical University, Taiyuan, 030001, Shanxi, PR China; Department of Otolaryngology Head & Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, PR China; Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, PR China; Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan, 030001, Shanxi, PR China; Yiducloud's Institute of Medical Data Science, Shanxi Medical University, Taiyuan, 030001, Shanxi, PR China. Electronic address:

Head and neck cancer (HNC), which includes epithelial malignancies of the upper aerodigestive tract (oral cavity, oropharynx, pharynx, hypopharynx, larynx, and thyroid), are slowly but consistently increasing, while the overall survival rate remains unsatisfactory. Because of the multifunctional anatomical intricacies of the head and neck, disease progression and therapy-related side effects often severely affect the patient's appearance and self-image, as well as their ability to breathe, speak, and swallow. Patients with HNC require a multidisciplinary approach involving surgery, radiation therapy, and chemotherapeutics. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110231DOI Listing

Safety of injectable semaglutide for type 2 diabetes.

Expert Opin Drug Saf 2020 May 19. Epub 2020 May 19.

Department of Diabetes and Endocrinology, Singleton Hospital, Swansea Bay University Health Board, Swansea, UK.

: Semaglutide is the most recently approved injectable glucagon-like peptide-1 receptor agonist (GLP-1RA) for people with type 2 diabetes (T2DM). It is one of three currently marketed GLP-1RAs that can be administered once weekly.: This review focusses on the safety of injectable semaglutide. Read More

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http://dx.doi.org/10.1080/14740338.2020.1772230DOI Listing

Substernal Goiter: a case to remember.

Rev Assoc Med Bras (1992) 2020 May;66(2):109-111

. Department of Internal Medicine. Hospital Trofa Saúde Vila Real. Vila Real, Portugal.

Goiter is a localized or generalized thyroid hypertrophy. It can remain within the cervical region or grow down until it invades the mediastinum. The signs and symptoms depend on the size and location of the goiter. Read More

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http://dx.doi.org/10.1590/1806-9282.66.2.109DOI Listing

Changes in Field of Binocular Single Vision and Ocular Deviation Angle After Balanced Orbital Decompression in Thyroid Eye Disease.

Ophthalmic Plast Reconstr Surg 2020 May 14. Epub 2020 May 14.

Department of Oculoplastic, Orbital & Lacrimal Surgery, Aichi Medical University Hospital, Aichi, Japan.

Purpose: To evaluate influential factors for changes in the binocular single vision (BSV) and ocular deviation angle in the medial direction after bilateral balanced orbital decompression in thyroid eye disease.

Methods: This retrospective study included 41 patients. The areas of BSV and the angles of medial ocular deviation on the Hess chart were measured. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001712DOI Listing

Spontaneous Orbital Wall Decompression in Thyroid Eye Disease: A Rare Feature.

Ophthalmic Plast Reconstr Surg 2020 May 15. Epub 2020 May 15.

Ophthalmic Plastic Surgery Service, L.V. Prasad Eye Institute, India.

Spontaneous orbital decompression is an incidental radiological finding in patients of thyroid eye disease. It is rare with few case reports in ophthalmic literature. The authors describe a 48-year-old female with thyroid eye disease who was found to have a spontaneous orbital decompression on computed tomography imaging. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001696DOI Listing

Combined role of lymph node ratio and serum thyroglobulin levels in predicting prognosis of papillary thyroid carcinoma.

Nucl Med Commun 2020 May 15. Epub 2020 May 15.

Department of Nuclear Medicine, Chonnam National University Hwasun Hospital.

Objectives: The aim of this study was to evaluate a prognostic value of the extent of metastatic lymph node combined with TSH-stimulated serum thyroglobulin (sTg) measured just before radioactive iodine (RAI) therapy in patients with papillary thyroid cancer (PTC).

Methods: The retrospective study included 468 patients with PTC who underwent total thyroidectomy with neck dissection and postoperative RAI therapy. The extent of metastatic lymph node was evaluated with the lymph node ratio (LNR) which was defined as the number of metastatic lymph nodes out of the number of total removed lymph nodes. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001214DOI Listing

Distribution and Prognostic Significance of Estrogen Receptor (ER), Estrogen Receptor (ER), and Human Epidermal Growth Factor Receptor 2 (HER-2) in Thyroid Carcinoma.

J Thyroid Res 2020 5;2020:6935724. Epub 2020 May 5.

Department of Endocrine Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, India.

Purpose: The primary aim of this study was to determine the incidence of estrogen receptor (ER), estrogen receptor (ER), and human epidermal growth factor receptor 2 (HER-2) expression in various subtypes of thyroid carcinoma (TC) of follicular origin and the secondary aim was to correlate the expression with various clinicopathologic prognostic factors.

Methods: Immunohistochemistry analysis was performed on archival paraffin-embedded tissue sections (1991-2016). ER, ER and HER-2 expressions were correlated with clinicopathologic prognostic factors, disease recurrence, and overall survival (OS). Read More

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http://dx.doi.org/10.1155/2020/6935724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222548PMC

Phospholipase A2 Receptor Autoantibodies as a Novel Serological Biomarker for Autoimmune Thyroid Disease Associated Nephropathy.

Front Immunol 2020 30;11:837. Epub 2020 Apr 30.

Wuxi Children's Hospital, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China.

To develop a highly sensitive immunoassay for PLA2R autoantibodies and study the relationship between PLA2R autoantibodies and autoimmune thyroid disease-associated nephropathy. We applied a highly sensitive time-resolved fluoroimmunoassay to quantitatively detect the concentration of phospholipase A2 receptor (PLA2R) antibodies in the serum of patients with Graves' disease, Hashimoto's thyroiditis (HT), nephrotic patients with idiopathic membranous nephropathy (IMN), and normal controls. We immunohistochemically analyzed the existing PLA2R target antigen in the thyroid tissue of patients with Graves' disease and HT, as well as the nephridial tissue of nephrotic patients with IMN. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204991PMC