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    The Role of Pregnancy, Perinatal Factors, and Hormones in Maternal Cancer Risk: A review of the evidence.
    J Intern Med 2018 Feb 24. Epub 2018 Feb 24.
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
    An understanding of the origin of cancer is critical for cancer prevention and treatment. Complex biological mechanisms promote carcinogenesis, and there is increasing evidence that pregnancy-related exposures influence fetal growth cell division and organ functioning and may have a long-lasting impact on health and disease susceptibility in the mothers and offspring. Nulliparity is an established risk factor for breast, ovarian, endometrial, and possibly pancreatic cancer, while the risk of kidney cancer is elevated in parous compared with nulliparous women. Read More

    Evaluation of adequacy of levo-thyroxine dosage in patients with differentiated thyroid carcinoma: correlation between morning and afternoon TSH determination.
    J Endocrinol Invest 2018 Feb 23. Epub 2018 Feb 23.
    Endocrine Unit, Policlinico San Martino, Viale Benedetto XV, 6, 16100, Genoa, Italy.
    Purpose: The aim of this study was to judge the reliability of evaluating thyroid-stimulating hormone (TSH) and free thyroxine (f-T4) in the morning and afternoon in differentiated thyroid carcinoma (DTC) patients.

    Methods: We evaluated 153 DTC patients, aged 61 ± 13 years, in active follow-up in our center after primary treatments and under stabilized levo-thyroxine (L-T4) posology. In each patient, morning and afternoon examinations were performed 1-3 months apart. Read More

    Acorrelation study between histological results and thyroid ultrasound findings. The TI-RADS classification.
    Endocrinol Diabetes Nutr 2018 Feb 20. Epub 2018 Feb 20.
    Servicio de Radiodiagnóstico, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España.
    Introduction: There are several classifications based on thyroid ultrasound for selecting suspected malignant thyroid nodules. The Thyroid Imaging Reporting and Data System (TI-RADS) classification proposed by Horvath in 2009 includes 6 categories.

    Objetives: To assess the sensitivity of the TI-RADS classification for diagnosing thyroid nodules. Read More

    High Prevalence of Antithyroid Antibodies in a New Zealand Cohort of Patients With Systemic Sclerosis.
    J Clin Rheumatol 2018 Feb 15. Epub 2018 Feb 15.
    Background: Autoimmune thyroid disease affects 1% of the general population, and autoimmune thyroid antibodies are noted in up to 15%.

    Objective: We hypothesized systemic sclerosis (SSc) is associated with higher prevalence of antithyroglobulin (anti-Tg) and anti-thyroid peroxidase (anti-TPO) antibodies) to justify monitoring of thyroid function for earlier detection and treatment.

    Methods: Waikato Hospital SSc clinic patients were prospectively tested for thyroid function tests and antithyroid antibodies (ATAs). Read More

    Theranostic radiopharmaceuticals: established agents in current use.
    Br J Radiol 2018 Feb 23:20170969. Epub 2018 Feb 23.
    Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
    Although use of the term "theranostic" is relatively recent, the concept goes back to the earliest days of nuclear medicine, with the use of radioiodine for diagnosis and therapy of benign and malignant thyroid disease being arguably the most successful molecular radiotherapy in history. A diagnostic scan withI-,I-, or a low activity ofI-iodide is followed by therapy with high activityI-iodide. Similarly, adrenergic tumours such as phaeochromocytoma and neuroblastoma can be imaged withI-metaiodobenzylguanidine (MIBG) and treated withI-MIBG. Read More

    Direct effects of thyroid hormones on hepatic lipid metabolism.
    Nat Rev Endocrinol 2018 Feb 23. Epub 2018 Feb 23.
    Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Programme, Duke-NUS Medical School, Singapore, Singapore.
    It has been known for a long time that thyroid hormones have prominent effects on hepatic fatty acid and cholesterol synthesis and metabolism. Indeed, hypothyroidism has been associated with increased serum levels of triglycerides and cholesterol as well as non-alcoholic fatty liver disease (NAFLD). Advances in areas such as cell imaging, autophagy and metabolomics have generated a more detailed and comprehensive picture of thyroid-hormone-mediated regulation of hepatic lipid metabolism at the molecular level. Read More

    Oral lichen planus - Differential diagnoses, serum autoantibodies, hematinic deficiencies, and management.
    J Formos Med Assoc 2018 Feb 19. Epub 2018 Feb 19.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
    Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease that occurs more frequently in middle-aged and elderly female patients. Previous studies indicate that OLP is a T-cell dysfunction-induced localized autoimmune disease. Clinically, six types of OLP, namely reticular, papular, plaque-like, atrophic/erosive, ulcerative, and bullous types, can be identified. Read More

    Prognostic factors for treatment success in patients with multidrug-resistant tuberculosis in China.
    Int J Tuberc Lung Dis 2018 Mar;22(3):300-305
    Zhejiang Prevention and Treatment Center of Tuberculosis, Zhejiang Chinese Medicine and Western Medicine Integrated Hospital, Hangzhou.
    Objective: To examine the clinical outcomes and associated prognostic factors among patients with multidrug-resistant tuberculosis (MDR-TB) in China.

    Methods: This retrospective study involved 243 patients with MDR-TB. All patients received standard regimens containing para-amino salicylic acid (PAS) and/or cycloserine (CS). Read More

    Small papillary thyroid carcinoma with minimal extrathyroidal extension should be managed as ATA low-risk tumor.
    J Endocrinol Invest 2018 Feb 22. Epub 2018 Feb 22.
    Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
    Purpose: According to American Thyroid Association (ATA) guideline, papillary thyroid cancer (PTC) with minimal extrathyroidal extension (mETE) is classified at "intermediate risk" of persistent/recurrent disease. However, the impact of mETE per se on patients' outcome is not fully understood. The aim of our study was to evaluate the prognostic significance of mETE in patients with PTC not submitted to therapeutic or prophylactic lymph node dissection, according to tumor size and other prognostic factors. Read More

    Permanent Hypoparathyroidism After Total Thyroidectomy in Children: Results from a National Registry.
    World J Surg 2018 Feb 22. Epub 2018 Feb 22.
    Department of Clinical Science, Lund University, 221 85, Lund, Sweden.
    Introduction: Hypoparathyroidism is the most common complication following thyroidectomy. There are few population-based reports on the rate of hypoparathyroidism in children. The incidence of medical treatment of permanent hypoparathyroidism in children is reported using a national registry. Read More

    Changes in Scope of Procedures Performed by Pediatric Otolaryngologists in the Past Decade.
    JAMA Otolaryngol Head Neck Surg 2018 Feb 22. Epub 2018 Feb 22.
    Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, Boston, Massachusetts.
    Importance: Monitoring current trends in pediatric otolaryngology will help adjust our training and practice paradigms in a way that ensures the long-term viability of the specialty.

    Objectives: To gauge the current scope of pediatric otolaryngology (ORL) practice within and outside of the United States and to identify changes in caseload over the past decade.

    Design, Setting, And Participants: An online survey was sent to pediatric ORL chairs and/or fellowship directors at 42 institutions in the United States and abroad. Read More

    Cowden syndrome: clinical case and a brief review.
    Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.
    Department of Dermatology and Venereology, Centro Hospitalar São João EPE, Porto, Portugal.
    Cowden syndrome is a rare genodermatosis of autosomal dominant inheritance characterized by multiple hamartomas in several organs and an increased risk of malignancies. We present the case of a 53-year-old man with a history of benign and malignant thyroid disease, intestinal polyposis, and Chiari malformation. He had several trichilemmomas, papillomatosis of the oral cavity, macular pigmentation of the glans penis, among other clinical features suggestive of Cowden syndrome. Read More

    Presence of autoimmune disease affects not only risk but also survival in patients with B-cell non-Hodgkin lymphoma.
    Hematol Oncol 2018 Feb 22. Epub 2018 Feb 22.
    School of Public Health, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
    Although autoimmune diseases (AIDs) are known to predispose to non-Hodgkin lymphoma (NHL), their association with NHL prognosis has rarely been investigated. We examined associations between autoimmunity and B-cell NHL onset by comparing AID history (determined by self-report and medication review and supplemented by chart review where possible) among 435 adult B-NHL patients in Hadassah-Hebrew University Medical Center, diagnosed 2009-2014, and 414 age-and-sex frequency-matched controls. We examined AIDs as a whole, B- and T-cell-mediated AIDs, and autoimmune thyroid diseases. Read More

    Antithyroid drugs inactivate TSH binding to the TSH receptor by their reducing action.
    Endocr Metab Immune Disord Drug Targets 2018 Feb 19. Epub 2018 Feb 19.
    Yamasa Ltd , Choshi, Chiba 288-0056. Japan.
    The effect of antithyroid drugs(ATDs)[methylmercaptoimidazole (MMI) and propylthiouracil (PTU)] and reducing agents (mercaptoethanol, dithiothreitol and cysteine) on bovine (b) TSH binding to human (h) and porcine (p) TSH receptor (R) was examined. (1) ATDs was pre-incubated with hTSHR coated tube for 1- 4 h, washed free of ATDs, and then 125I-bTSH binding to hTSHR after 1 h incubation was examined. MMI (10-40 mM) decreased 125I-bTSH binding in a dose-dependent manner and binding decreased proportionally as pre-incubation time increased from 1 to 4 h. Read More

    Hormone treatments in congestive heart failure.
    J Int Med Res 2018 Jan 1:300060518761262. Epub 2018 Jan 1.
    2 Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
    The common ultimate pathological feature for all cardiovascular diseases, congestive heart failure (CHF), is now considered as one of the main public health burdens that is associated with grave implications. Neurohormonal systems play a critical role in cardiovascular homeostasis, pathophysiology, and cardiovascular diseases. Hormone treatments such as the newly invented dual-acting drug valsartan/sacubitril are promising candidates for CHF, in addition to the conventional medications encompassing beta receptor blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and mineralocorticoid receptor antagonists. Read More

    Effects of iodine-131 radiotherapy on Th17/Tc17 and Treg/Th17 cells of patients with differentiated thyroid carcinoma.
    Exp Ther Med 2018 Mar 21;15(3):2661-2666. Epub 2017 Dec 21.
    Department of Nuclear Medicine, Zhejiang Provincial Hospital of Traditional Chinese Medicine, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China.
    T helper 17 (Th17), T cytotoxic 17 (Tc17) and regulatory T (Treg) cells serve important roles in a number of inflammatory and autoimmune diseases. The aim of the present study was to examine the distribution of Th17, Tc17 and Treg cells in patients with differentiated thyroid cancer (DTC) prior to as well as 7, 30 and 90 days following radioactive iodine-131 (I) therapy, and to elucidate the probable effects ofI therapy on Th17/Tc17 and Treg/Th17 cells in patients with DTC. A total of 40 patients with DTC (26 female; 14 male) between the ages of 24 and 72 years, as well as 13 age- and sex-matched healthy subjects were included in this study. Read More

    Clinical Feasibility of Continuously Monitored Data for Heart Rate, Physical Activity, and Sleeping by Wearable Activity Trackers in Patients with Thyrotoxicosis: Protocol for a Prospective Longitudinal Observational Study.
    JMIR Res Protoc 2018 Feb 21;7(2):e49. Epub 2018 Feb 21.
    Department of Internal Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Republic Of Korea.
    Background: Thyrotoxicosis is a common disease caused by an excess of thyroid hormones. The prevalence of thyrotoxicosis about 2% and 70-90% of thyrotoxicosis cases are caused by Graves' disease, an autoimmune disease, which has a high recurrence rate when treated with antithyroid drugs such as methimazole or propylthiouracil. The clinical symptoms and signs of thyrotoxicosis include palpitation, weight loss, restlessness, and difficulty sleeping. Read More

    A Single Radioactive Iodine Treatment has a Deleterious Effect on Ovarian Reserve in Women with Thyroid Cancer: Results of a Prospective Pilot Study.
    Thyroid 2018 Feb 21. Epub 2018 Feb 21.
    Tel Aviv Sourasky Medical Center, 26738, Institute of Endocrinology, Metabolism, and Hypertension, Tel Aviv, Israel.
    Background: Women of reproductive age with differentiated thyroid cancer (DTC) often need to receive radioactive iodine (RAI) treatment after surgery. In contrast to the well documented effect of RAI on testicular function, the potential negative effects of this treatment on ovarian reserve have been largely dismissed. The objective of this pilot study was to examine the possibility that RAI treatment is deleterious to the ovarian reserve by prospectively measuring the concentration of anti-Müllerian hormone (AMH) after this treatment. Read More

    Loss of HCN2 leads to delayed gastrointestinal motility and reduced energy intake in mice.
    PLoS One 2018 21;13(2):e0193012. Epub 2018 Feb 21.
    Davee Department of Neurology and Clinical Neurosciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
    Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) channels are important regulators of excitability in neural, cardiac, and other pacemaking cells, which are often altered in disease. In mice, loss of HCN2 leads to cardiac dysrhythmias, persistent spike-wave discharges similar to those seen in absence epilepsy, ataxia, tremor, reduced neuropathic and inflammatory pain, antidepressant-like behavior, infertility, and severely restricted growth. While many of these phenotypes have tissue-specific mechanisms, the cause of restricted growth in HCN2 knockout animals remains unknown. Read More

    In iodine-induced thyrotoxicosis, steroid therapy today could keep the surgical knife at bay.
    J Pediatr Endocrinol Metab 2018 Feb 21. Epub 2018 Feb 21.
    Division of Endocrinology, Department of Pediatrics, Nationwide Children's Hospital/The Ohio State University College of Medicine, Columbus, OH, USA.
    Background: Amiodarone-induced thyrotoxicosis (AIT) type 2, characterized as a destructive thyroiditis, is well described in the medical literature; however, iodine-induced thyrotoxicosis (IIT) is not, though the latter has similar features and can be managed similarly.

    Case Presentation: We present a 17-year-old female who presented with a history of an intermittent goiter with thyroid function tests (TFTs): thyroid-stimulating hormone (TSH)<0.015 (0. Read More

    99mTc-MDP SPECT-CT and Ultrasound in the Diagnosis and Staging of Thyroid Metastasis From Osteosarcoma.
    Clin Nucl Med 2018 Feb 21. Epub 2018 Feb 21.
    The classification of thyroid nodules in children is often difficult, especially in pretreated patients with metastatic disease. In osteosarcoma patients, Tc-MDP SPECT/CT is used for primary and follow-up staging. Bone and soft tissue metastases can be revealed because of Tc-MDP imaging of osteoid-producing metastases. Read More

    Case Series: Noninflammatory Thyroid Eye Disease.
    Ophthal Plast Reconstr Surg 2018 Feb 16. Epub 2018 Feb 16.
    Division of Orbital and Ophthalmic Plastic Surgery, Stein Eye Institute.
    Purpose: Patients presenting with thyroid eye disease (TED) usually follow a well-defined self-remitting course characterized by an active inflammatory phase followed by an inactive fibrotic phase. We present 3 cases where patients presented primarily with signs of progressive fibrosis and no signs of prior active inflammation.

    Methods: We reviewed the clinical notes and investigations of 3 patients who presented to our center between January 2015 and August 2017. Read More

    Soft Tissue Metrics in Thyroid Eye Disease: An International Thyroid Eye Disease Society Reliability Study.
    Ophthal Plast Reconstr Surg 2018 Feb 16. Epub 2018 Feb 16.
    Vanderbilt Eye Institute, Vanderbilt University School of Medicine, Nashville, Tennessee, U.S.A.
    Purpose: To determine the reliability of 3 scales for assessing soft tissue inflammatory and congestive signs associated with thyroid eye disease.

    Methods: This was a multicentered prospective observational study, recruiting 55 adults with thyroid eye disease from 9 international centers. Six thyroid eye disease soft tissue features were measured; each sign graded using 3 scales (presence/absence [0-1], 3-point scale [0-2], and percentage [0-100]). Read More

    Pneumatocele during sorafenib therapy: first report of an unusual complication.
    Oncotarget 2018 Jan 22;9(5):6652-6656. Epub 2017 Dec 22.
    Liver Unit, Department of Internal Medicine, Clínica Universidad de Navarra-IDISNA and CIBEREHD, Pamplona, Navarra, Spain.
    Sorafenib is a multi-kinase inhibitor and a vascular endothelial growth factor (VEGF) inhibitor approved to treat patients with advanced hepatocellular carcinoma, renal cell carcinoma and differentiated thyroid carcinoma. Its most common side effects are asthenia/fatigue, skin toxicity, diarrhea and arterial hypertension. Reported respiratory adverse reactions include dyspnea, cough, pleural effusion and hoarseness. Read More

    A single-center retrospective study of factors related to the effects of intravenous glucocorticoid therapy in moderate-to-severe and active thyroid-associated ophthalmopathy.
    BMC Endocr Disord 2018 Feb 20;18(1):13. Epub 2018 Feb 20.
    Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, No. 639 ZhiZaoJu Road, Shanghai, 200011, China.
    Background: Intravenous glucocorticoids (ivGC) have been recommended as a first-line treatment of moderate-to-severe and active thyroid-associated ophthalmopathy (TAO). However, not all patients are responsive to ivGC. The identification of potential factors used to predict their efficacy and the selection of suitable patients have both been lacking. Read More

    Clinicopathological indicators of survival among patients with pulmonary carcinoid tumor.
    Acta Oncol 2018 Feb 20:1-8. Epub 2018 Feb 20.
    a HUSLAB, Helsinki Biobank, Department of Pathology , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
    Background: Pulmonary carcinoids (PC) are rare malignant neoplasms that cover approximately 1% of all lung cancers. PCs are classified by histological criteria as either typical (TC) or atypical (AC). Histological subtype is the most studied prognostic factor. Read More

    Type 1 diabetes mellitus and Graves' disease in Down's syndrome--a rare combination.
    Afr J Med Med Sci 2016 Sep;45(3):299-301
    Background: Autoimmune diseases including thyroid. disorders, type 1 diabetes and celiac disease are commoner in persons with Down's syndrome compared with the general population. Coexistent type 1 diabetes and hyperthyroidism in Down's syndrome is however not commonly reported in literature. Read More

    Preoperative imaging for parathyroid localization in patients with concurrent thyroid disease: A systematic review.
    Head Neck 2018 Feb 20. Epub 2018 Feb 20.
    Department of Otolaryngology - Head and Neck Surgery, Loma Linda University Medical Center, Loma Linda, California.
    Background: Thyroid disease occurs more frequently in patients with hyperparathyroidism than the general population and hinders parathyroid localization. Identifying thyroid pathology before operating improves management and avoids the risks of reoperation in the neck. This review assesses imaging studies in patients with hyperparathyroidism and thyroid pathology to identify the ideal imaging methodology for patients with multigland disease. Read More

    [Is scleromyxedema a skin problem or systemic pathological process?]
    Arkh Patol 2018 ;80(1):63-66
    N.I. Pirogov Russian National Research Medical University, Moscow, Russia.
    Scleromyxedema is regarded as a rare cutaneous mucinosis from a group of lichen myxedematosus characterized by diffuse mucin deposition, sclerosis, and lichenoid eruptions in the absence of thyroid disease. The paper discusses the pathogenesis of the disease and histological changes in tissues. It underlines the need for using histochemical tests to identify acidic and neutral glycosaminoglycans and gives a differential diagnosis of this disease. Read More

    [Primary biliary cholangitis. Part 1. State of the art, epidemiology, physiopathology and clinical manifestations].
    Rev Gastroenterol Peru 2017 Oct-Dec;37(4):357-364
    Universidad Nacional de Colombia. Bogotá, Colombia; Hospital Universitario Nacional de Colombia. Bogotá, Colombia.
    Primary biliary cholangitis (PBC) is a chronic autoimmune cholangiopathy characterized by a selective destruction of biliary epithelial cells of small and medium caliber hepatic ducts, which mainly affects women. The main symptoms are fatigue and pruritus, however, a large proportion of patients may be asymptomatic. The diagnosis is based on AMA titers >1:40, alkaline phosphatase >1. Read More

    Thyroid-Stimulating Hormone-Stimulated Human Adipocytes Express Thymic Stromal Lymphopoietin.
    Horm Metab Res 2018 Feb 19. Epub 2018 Feb 19.
    Chronic Disease Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
    When recombinant human (rh) thyroid-stimulating hormone (TSH) is administered to thyroid cancer survivors, an acute extra-thyroidal effect raises pro-inflammatory cytokines and activates platelets. Thymic stromal lymphopoietin (TSLP) is a cytokine recently implicated in platelet activation. Our aim was to measure platelet microparticle levels after rhTSH stimulation in vivo, and to investigate TSLP expression in TSH-stimulated human adipocytes in culture. Read More

    Delayed Presentation of Submucosal Retained Toothbrush from Self-Inflicted Injury in Patient with Schizophrenia.
    Case Rep Emerg Med 2017 31;2017:2480140. Epub 2017 Dec 31.
    Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
    Foreign body ingestion occurs in not only children but also adults, particularly those with history of neurologic disease, alcohol use, or psychiatric disease. We present the case of a 40-year-old male with schizophrenia who presented to the emergency room with a long history of pharyngeal foreign body sensation which had recently progressed to include trismus, odynophagia, and dyspnea. Flexible laryngoscopy demonstrated fullness of the right posterior pharyngeal wall and computed tomography (CT) showed a linear opaque foreign body extending from the level of the oropharynx to the thyroid ala. Read More

    Novel targeted therapies and immunotherapy for advanced thyroid cancers.
    Mol Cancer 2018 Feb 19;17(1):51. Epub 2018 Feb 19.
    Alexandria Comprehensive Cancer center, Alexandria, Egypt.
    Thyroid cancer is a frequently encountered endocrine malignancy. Despite the favorable prognosis of this disease, 15-20% of differentiated thyroid cancer (DTC) cases and most anaplastic types, remain resistant to standard treatment options, including radioactive iodine (RAI). In addition, around 30% of medullary thyroid cancer (MTC) cases show resistance after surgery. Read More

    The clinicopathological and prognostic significance of programmed cell death ligand 1 (PD-L1) expression in patients with non-medullary thyroid cancer: a systematic review and meta-analysis.
    Thyroid 2018 Feb 17. Epub 2018 Feb 17.
    Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia.
    Background: Evidence has shown that PD-L1 overexpression is associated with poor prognosis and resistance to immune therapies in several human cancers. However, data on the prognostic significance of PD-L1 expression in thyroid cancer is limited and remains controversial. In this systematic review and meta-analysis, we aimed to comprehensively evaluate the clinicopathological significance and prognostic value of PD-L1 expression in non-medullary thyroid cancers. Read More

    Multiple endocrine neoplasia 2A (MEN 2A) syndrome.
    Bratisl Lek Listy 2018 ;119(2):120-125
    Introduction: In the MEN 2A syndrome, which is the most common of the three types of MEN, three endocrine systems are affected simultaneously or subsequently by the development of tumours manifested by medullary thyroid gland carcinoma, pheochromocytoma (often bilateral) and hyperparathyroidism.

    Material And Methods: 27 patients from 3 families affected by MEN 2A syndrome were examined clinically (by detecting the effects of catecholamine overproduction), biochemically (screening for metanephrine and normetanephrine in the serum), visualization (CT, MRI, MIBG, PET CT) and some of them also genetically (DNA fragment analysis obtained by PCR amplification).

    Results: Familial incidence of pheochromocytoma was confirmed in 10 patients (4 males, 5 females and one girl) aged 6 to 54 years (average 22. Read More

    A Potential Prognostic Long Noncoding RNA Signature to Predict Recurrence among ER-positive Breast Cancer Patients Treated with Tamoxifen.
    Sci Rep 2018 Feb 16;8(1):3179. Epub 2018 Feb 16.
    Department of the Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, 400016, China.
    Limited predictable long noncoding RNA (lncRNA) signature was reported in tamoxifen resistance among estrogen receptor (ER)-positive breast cancer (BC) patients. The aim of this study was to identify and assess prognostic lncRNA signature to predict recurrence among ER-positive BC patients treated with tamoxifen. Cohorts from Gene Expression Omnibus (GEO) (n = 298) and The Cancer Genome Atlas (TCGA) (n = 160) were defined as training and validation cohort, respectively. Read More

    Does rituximab improve clinical outcomes of patients with thyroid-associated ophthalmopathy? A systematic review and meta-analysis.
    BMC Ophthalmol 2018 Feb 17;18(1):46. Epub 2018 Feb 17.
    Department of Ophthalmology, the Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, 310009, China.
    Background: The current therapies of thyroid-associated ophthalmopathy (TAO) were still a challenging matter. In this study, we aimed to contrast the impact of before- after rituximab (RTX) therapy in the patients with TAO.

    Methods: We searched the PubMed, EMBASE, and SCOPUS databases for articles published up to July 3, 2017. Read More

    The effect of Metformin treatment in obese insulin-resistant patients with euthyroid goiter.
    Acta Clin Belg 2018 Feb 16:1-7. Epub 2018 Feb 16.
    a Department of Endocrinology , Iuliu Haţieganu University of Medicine and Pharmacy , Cluj-Napoca , Romania.
    Objective The study's objective was to evaluate the thyroid parameters in obese insulin-resistant patients with euthyroid diffuse or nodular goiter, following Metformin treatment. Patients and methods The study was experimental, open, and prospective. Fifty-three patients aged 18-68 were enrolled for two years. Read More

    Familial Nonmedullary Thyroid Carcinoma: A Retrospective Analysis of 117 Families.
    Chin Med J (Engl) 2018 Feb;131(4):395-401
    Department of Head and Neck Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
    Background: The first and most important step in characterizing familial nonmedullary thyroid carcinoma (NMTC) is to distinguish the true familial patients, which is the prerequisite for all accurate analyses. This study aimed to investigate whether patients from families with ≥3 first-degree relatives affected with NMTC have different characteristics than patients from families with only two affected members, and to compare these patients with those with sporadic disease.

    Methods:: We analyzed the clinicopathological features and prognosis of 209 familial and 1120 sporadic cases of NMTC. Read More

    Role of the T and B lymphocytes in pathogenesis of autoimmune thyroid diseases.
    Thyroid Res 2018 13;11. Epub 2018 Feb 13.
    Department of Pediatrics, Endocrinology and Diabetes with a Cardiology Unit, Medical University of Bialystok, ul. Waszyngtona 17, 15-274 Białystok, Poland.
    Autoimmune thyroid disorders (AITD) broadly include Graves' disease and Hashimoto's thyroiditis which are the most common causes of thyroid gland dysfunctions. These disorders develop due to complex interactions between environmental and genetic factors and are characterized by reactivity to self-thyroid antigens due to autoreactive lymphocytes escaping tolerance. Both cell-mediated and humoral responses lead to tissue injury in autoimmune thyroid disease. Read More

    RRS1 gene expression involved in the progression of papillary thyroid carcinoma.
    Cancer Cell Int 2018 13;18:20. Epub 2018 Feb 13.
    1Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, MOE Key Laboratory of Major Diseases in Children, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
    Background: Papillary thyroid carcinoma (PTC) is one of the most frequent malignancies of the endocrine system, whose mechanisms of pathogenesis, progression and prognosis are still far from being clearly elucidated. Despite an increasing body of evidences highlights ribosome biogenesis regulator homolog (RRS1) as a ribosome biogenesis protein in yeast and plants, little is known about human RRS1 function.

    Methods: Proliferation, cell cycle and apoptosis of PTC cells were assessed following the knockdown of RRS1 expression though MTT, colony formation assay, and flow cytometry. Read More

    Papular mucinosis, or localized lichen myxedematosis (LM) (discrete papular type).
    Dermatol Online J 2017 Dec 15;23(12). Epub 2017 Dec 15.
    New York University Langone Health, New York.
    Lichen myxedematosus is condition characterized by localized areas of dermal deposition of mucin, presenting with firm papules localized to few areas of the body. The condition needs to be excluded from scleromyxedema, which, in addition to the firm papular eruption, has areas of induration and is usually associated with a monoclonal gammopathyand systemic symptoms. We present a 62-year-old woman with a several-year history of asymptomatic, firm papules over the face and arms with no evidence of thyroid disease or a monoclonal gammopathy,which is consistent with a diagnosis of localized lichen myxedematosus, the discrete papular variant. Read More

    Thyroid carcinoma producing β-human chorionic gonadotropin shows different clinical behavior.
    Pathol Int 2018 Feb 15. Epub 2018 Feb 15.
    Department of Pathology, Shandong University School of Basic Medical Sciences, 44#, Wenhua Xi Road, Jinan, Shandong, 250012, PR China.
    Columnar cell variant of papillary thyroid carcinoma (CCV-PTC) is an unusual neoplasm, the clinical behavior of which mainly depends on the encapsulation or infiltration. Patients with extensive extrathyroidal extension usually have an aggressive biological behavior. This study confirmed that beta-human chorionic gonadotropin (β-hCG) secreting invasive CCV-PTC has good prognosis comparing with a cohort of follicular cell differentiated thyroid carcinoma. Read More

    Hyperparathyroidism Mimicking Metastatic Bone Disease: A Case Report and Review of Literature.
    J Adolesc Young Adult Oncol 2018 Feb 15. Epub 2018 Feb 15.
    3 Department of Nuclear Medicine, Delhi State Cancer Institute , Delhi, India .
    Multiple osteolytic lesions are usually associated with metastatic involvement of the bone; however, metabolic bone diseases should also be included in the differential diagnosis. In this study, we describe a case of primary hyperparathyroidism (PHPT) with multiple osteolytic lesions that was diagnosed initially as having metastatic bone involvement. The laboratory results showed hypercalcemia and raised alkaline phosphatase along with fibrosis in the bone marrow biopsy with no increase in tumor markers and normal serum protein electrophoresis. Read More

    De novo variants in Myelin regulatory factor (MYRF) as candidates of a new syndrome of cardiac and urogenital anomalies.
    Am J Med Genet A 2018 Feb 15. Epub 2018 Feb 15.
    Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
    Myelin Regulatory Factor (MYRF) is a transcription factor that has previously been associated with the control of the expression of myelin-related genes. However, it is highly expressed in human tissues and mouse embryonic tissues outside the nervous system such as the stomach, lung, and small intestine. It has not previously been reported as a cause of any Mendelian disease. Read More

    High prevalence of HCV (GT4)-related TSH abnormality among 13402 Egyptian patients treated with direct acting antiviral therapy.
    Hepatol Int 2018 Feb 14. Epub 2018 Feb 14.
    Hepatology and Endemic Medicine Department, Cairo University, Cairo, 11311, Egypt.
    Background: HCV is associated with several extra hepatic diseases including thyroid dysfunction. This study aims at evaluating prevalence of thyroid dysfunction and its possible predictors in a large cohort of HCV GT4-infected patients, and the role of thyroid dysfunction as a predictor of response in the setting of direct acting antivirals (DAAs).

    Methods: Patients registered on the web-based registry system to receive therapy for chronic HCV in Beheira governorate viral hepatitis specialized treatment center affiliated to the National committee for control of viral hepatitis (NCCVH), Ministry of health, Egypt in the period from January 2015 to October 2016. Read More

    L-Thyroxine intake as a potential risk factor for the development of fatigue in breast cancer patients undergoing chemotherapy.
    Support Care Cancer 2018 Feb 14. Epub 2018 Feb 14.
    Division of Physical Activity, Prevention and Cancer, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, 69120, Heidelberg, Germany.
    Purpose: L-Thyroxine is one of the most commonly prescribed drugs and accordingly used by many breast cancer patients with thyroid disorders. Hence, potential interactions of chemotherapy with L-thyroxine, possibly contributing to fatigue, would be of high clinical relevance. Therefore, we investigated fatigue and underlying pathways in L-thyroxine-using breast cancer patients during chemotherapy. Read More

    Graves' disease coexisting with resistance to thyroid hormone: a rare case.
    Clin Case Rep 2018 Feb 29;6(2):337-341. Epub 2017 Dec 29.
    Endocrine and Diabetes CenterAffiliated Hospital of Integrated Traditional Chinese and Western MedicineJiangsu Province Academy of Traditional Chinese MedicineNanjing University of Traditional Chinese MedicineNanjingChina.
    A rare case of resistance to thyroid hormone (RTH) complicated with Graves' hyperthyroidism was reported. The management of this disease is similar to that of Graves' disease. Antithyroid drug therapy is the first choice, and iodine therapy and surgery are not recommended due to the possibility of severe hypothyroidism and enlargement of the pituitary gland. Read More

    Loss of NDRG2 in liver microenvironment inhibits cancer liver metastasis by regulating tumor associate macrophages polarization.
    Cell Death Dis 2018 Feb 14;9(2):248. Epub 2018 Feb 14.
    State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China.
    The liver is the predominant metastatic site for several types of malignancies. Tumor-associated macrophages (TAMs) in the liver play crucial roles in the metastasis process. Shifting tumor-promoting M2-like TAMs toward the M1-like phenotype, which exerts tumor suppressor functions via phagocytosis and the secretion of inhibitory factors, may be a potential therapeutic strategy for liver cancer metastasis treatment. Read More

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