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    Clinical outcomes after delayed thyroid surgery in patients with papillary thyroid microcarcinoma.
    Eur J Endocrinol 2017 Apr 21. Epub 2017 Apr 21.
    W Kim, Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of.
    Objective: Active surveillance is an option for patients with papillary thyroid microcarcinoma (PTMC). However, the long-term clinical outcomes after delayed surgery remain unclear. We compared the long-term clinical outcomes of PTMC patients according to the time interval between initial diagnosis and surgery. Read More

    Genomic answers for recurrent spontaneous abortion in Saudi Arabia: An array comparative genomic hybridization approach.
    Reprod Biol 2017 Apr 18. Epub 2017 Apr 18.
    Center of Excellence in Genomic Medicine Research, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address:
    To study the genomics/genetic factors associated with recurrent spontaneous abortion (RSA), as ∼50% of RSA are unexplained. However, chromosome abnormalities have been reported to play major role in RSA. We performed whole genome array-CGH based genomic analysis of forty four Saudi RSA patients to identify potential molecular and chromosomal abnormalities. Read More

    Protein oxidation and autoantibodies' reactivity against malondialdehyde and hydrogen peroxide-modified thyroid antigens in plasma of patients with Graves' disease and Hashimoto Thyroiditis.
    Chem Biol Interact 2017 Apr 18. Epub 2017 Apr 18.
    Laboratory LR11ES45, Research Group "Biotechnology and Pathology", National School of Engineers, Univeristy of Sfax, Tunisia; Service of Nuclear Medicine, CHU Habib Bourguiba, Sfax, Tunisia.
    The aim of this study was first to investigate the oxidative proteins modifications in the plasma of both autoimmune thyroid diseases (AITD), Graves' disease (GD) and Hashimoto Thyroiditis (HT). Then, the impact of these oxidative modifications on immune response was evaluated by measuring the reactivity of patients' autoantibodies against malondialdéhyde (MDA) and Hydrogen peroxide (H2O2) modified thyroid antigens (T.Ag) in comparison to native ones. Read More

    The p.G534E variant of HABP2 is not associated with sporadic papillary thyroid carcinoma in a Polish population.
    Oncotarget 2017 Apr 6. Epub 2017 Apr 6.
    Oncology Clinic, Holycross Cancer Centre, Kielce, Poland.
    Thyroid cancer is one of the most frequently diagnosed cancers of the endocrine system. There are no known genetic risk factors for non-medullary thyroid cancer, other than a small number of hereditary syndromes; however, approximately 5% of non-medullary thyroid cancer, designated familial non-medullary thyroid cancer, exhibits heritability. The p. Read More

    Impact of thyroid disease on testicular function.
    Endocrine 2017 Apr 20. Epub 2017 Apr 20.
    Department of Clinical and Experimental Medicine, University of Catania, Policlinico "G. Rodolico", Via Santa Sofia 78, 95123, Catania, Italy.
    Introduction: Testis was considered unresponsive to thyroid hormone for a long time. However, like in animals, the presence of thyroid hormone receptors in different testicular cell types was demonstrated also in humans. Accordingly, thyrotoxicosis and hypothyroidism have remarkable effects on testicular function and more extensively on fertility. Read More

    Cardiovascular risk may be increased in women with unexplained infertility.
    Clin Exp Reprod Med 2017 Mar 31;44(1):28-32. Epub 2017 Mar 31.
    Department of Obstetrics and Gynecology, Suleymaniye Maternity, Research, and Training Hospital, Istanbul, Turkey.
    Objective: Growing evidence suggests that increased cardiovascular disease (CVD) risk is associated with female infertility caused by conditions such as polycystic ovarian disease, obesity, thyroid dysfunction, and endometriosis. The aim of this study was to evaluate whether any relationship exists between CVD and unexplained infertility.

    Methods: Sixty-five women with unexplained infertility and 65 fertile controls were enrolled in the study. Read More

    Bioinformatics analysis of key genes and latent pathway interactions based on the anaplastic thyroid carcinoma gene expression profile.
    Oncol Lett 2017 Jan 30;13(1):167-176. Epub 2016 Nov 30.
    Department of Hepatobiliary Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
    Anaplastic thyroid carcinoma (ATC) is an aggressive malignant disease in older adults with a high mortality rate. The present study aimed to examine several key genes and pathways, which are associated with ATC. The GSE33630 gene expression profile was downloaded from the Gene Expression Omnibus database, which included 11 ATC and 45 normal thyroid samples. Read More

    A Microarray Immunoassay for Serum Thyrotropin and Thyroglobulin Using Antibodies Immobilized on Track-Etched Membranes.
    Indian J Clin Biochem 2017 Jun 6;32(2):193-199. Epub 2016 Jul 6.
    Radiation Medicine Centre, Bhabha Atomic Research Centre, Mumbai, India.
    Serum thyroglobulin (Tg) and thyroid stimulating hormone (TSH) measurements have evolved as important analytes for monitoring the prognosis of patients with differentiated thyroid cancer, post-thyroidectomy. Individual analyte immunoassay is the current practice in clinical pathology, but the simultaneous assay for all relevant analytes for a given disease, can reduce assay costs, improve patient compliance and give the clinician more information for an unequivocal diagnosis. Microarray immunoassay (MI) can achieve this goal and, hence, we have developed and validated a immuno-radiometric MI for quantitation of serum TSH and Tg by using highly micro-porous polycarbonate (PC) track-etched membranes (TEM) to immobilize the monoclonal anti-TSH and polyclonal anti-Tg antibodies in ~1 mm diameter spots. Read More

    Hypothyroidism in Pediatric Population - Bosnian and Herzegovinian Situation.
    Med Arch 2017 Feb 5;71(1):62-65. Epub 2017 Feb 5.
    Faculty of Medicine, Sarajevo School of Science and Technology, Sarajevo, Bosnia and Herzegovina.
    Introduction: Thyroid gland diseases in children are in second place by frequency among all endocrine disorders. When interpreting the results of the thyroid function assessment it should be taken into account the significant differences in the concentrations of TSH, thyroid hormones, thyroid binding proteins and calcitonin among children of different ages.

    Goal: To present the age and sex structure of the patients diagnosed with hypothyroidism, evaluate diagnostic methods for making diagnosis, evaluation of etiology of hypothyroidism, with special review of the therapeutic modality. Read More

    Thyroid Autoimmunity in Patients with Chronic Urticaria.
    Med Arch 2017 Feb 5;71(1):29-31. Epub 2017 Feb 5.
    Department of Dermatology and Venereology, University Clinical Center Sarajevo, Bosnia and Herzegovina.
    Introduction: chronic urticaria (CU) is a skin disorder characterized by transient, pruritic wheals persisting for longer than 6 weeks. The etiopathogenesis of the disease is still unclear, but there is evidence that autoimmunity and endocrine dysfunction may be involved.

    Aim: the aim of this study was to determine whether chronic urticaria is statistically associated with thyroid autoimmunity. Read More

    Investments in cancer research awarded to UK institutions and the global burden of cancer 2000-2013: a systematic analysis.
    BMJ Open 2017 Apr 20;7(4):e013936. Epub 2017 Apr 20.
    Harvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
    Objectives: To systematically categorise cancer research investment awarded to United Kingdom (UK) institutions in the period 2000-2013 and to estimate research investment relative to disease burden as measured by mortality, disability-adjusted life years (DALYs) and years lived with disability (YLDs).

    Design: Systematic analysis of all open-access data.

    Setting And Participants: Public and philanthropic funding to all UK cancer research institutions, 2000-2013. Read More

    Vitamin D receptor, Retinoid X receptor and peroxisome proliferator-activated receptor γ are overexpressed in BRCA1 mutated breast cancer and predict prognosis.
    J Exp Clin Cancer Res 2017 Apr 20;36(1):57. Epub 2017 Apr 20.
    Department of Obstetrics and Gynecology, Ludwig-Maximilians-University of Munich, Munich, Germany.
    Background: BRCA1 mutated breast cancers are commonly diagnosed as negative for classical hormone receptors i.e. estrogen receptor, progesterone receptor and/or Her2. Read More

    Urinary triclosan concentrations during pregnancy and birth outcomes.
    Environ Res 2017 Apr 17;156:505-511. Epub 2017 Apr 17.
    Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
    Background: Triclosan is an antimicrobial chemical used in consumer products, and exposure is ubiquitous among pregnant women in the United States. Triclosan may reduce the levels of thyroid hormones that are important for fetal growth and development.

    Objective: We investigated the relationship of prenatal triclosan exposure with birth anthropometry and gestational duration. Read More

    Understanding the Risks and Harms of Management of Incidental Thyroid Nodules: A Review.
    JAMA Otolaryngol Head Neck Surg 2017 Apr 20. Epub 2017 Apr 20.
    Department of Radiology, The Ohio State University Wexner Medical Center, Columbus.
    Importance: Incidental thyroid nodules are defined as nodules originally detected in a patient with no thyroid-related clinical symptoms, examination findings, or suspected thyroid disease. Medical imaging for diseases in the neck, chest, and spine is a common source of incidental thyroid nodules. They are easily detected but poorly characterized. Read More

    Altered structure and function of adipose tissue in long-lived mice with growth hormone-related mutations.
    Adipocyte 2017 Mar 21:1-7. Epub 2017 Mar 21.
    a Department of Internal Medicine , Southern Illinois University School of Medicine , Springfield , Illinois , USA.
    A major focus of biogerontology is elucidating the role(s) of the endocrine system in aging and the accumulation of age-related diseases. Endocrine control of mammalian longevity was first reported in Ames dwarf (Prop1(df)) mice, which are long-lived due to a recessive Prop1 loss-of-function mutation resulting in deficiency of growth hormone (GH), thyroid-stimulating hormone, and prolactin. Following this report, several other GH-related mutants with altered longevity have been described including long-lived Snell dwarf and growth hormone receptor knockout mice, and short-lived GH overexpressing transgenic mice. Read More

    Phase I dose-escalation study of milciclib in combination with gemcitabine in patients with refractory solid tumors.
    Cancer Chemother Pharmacol 2017 Apr 19. Epub 2017 Apr 19.
    Drug Development Department (DITEP), Gustave Roussy Cancer Centre, Université Paris-Saclay, 114 Rue Eduard Vaillant, 94805, Villejuif, France.
    Background: This phase I trial evaluated the safety and tolerability of milciclib, an inhibitor of multiple cyclin-dependent kinases and tropomycin receptor kinase A, in combination with gemcitabine in patients with refractory solid tumors.

    Design: Sixteen patients were enrolled and treated with milciclib at three dose levels (45 mg/m(2)/day, n = 3; 60 mg/m(2)/day, n = 3; and 80 mg/m(2)/day, n = 10) with a fixed dose of gemcitabine (1000 mg/m(2)/day). Milciclib was administered orally once daily for 7 days on/7 days off in a 4-week cycle, and gemcitabine was administered intravenously on days 1, 8 and 15 in a 4-week cycle. Read More

    ZCCHC12, a novel oncogene in papillary thyroid cancer.
    J Cancer Res Clin Oncol 2017 Apr 19. Epub 2017 Apr 19.
    Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
    Purpose: Thyroid cancer is the most common endocrine malignancy worldwide. The molecular mechanisms underlying thyroid tumorigenesis remain unclear. Some studies suggested that the ZCCHC12 gene correlates with certain diseases. Read More

    Thyroid skeletal metastasis: pain management with verteblation.
    BMJ Support Palliat Care 2017 Apr 19. Epub 2017 Apr 19.
    Department of Radiology, Sant'Andrea University Hospital La Sapienza, Rome, Italy.
    The combination of percutaneous vertebroplasty with radiofrequency ablation (verteblation) has not shown to be an effective measure of pain management in patients with metastatic lesions of the spine. The use of this novel technique has not been previously described in metastatic disease from thyroid cancer. We would like to report our experience after treating a patient affected by a thyroid carcinoma and an osteolytic spine metastasis. Read More

    Hobnail variant of papillary thyroid carcinoma: molecular profiling and comparison to classical papillary thyroid carcinoma, poorly differentiated thyroid carcinoma and anaplastic thyroid carcinoma.
    Oncotarget 2017 Mar;8(13):22023-22033
    Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.
    Background: As a rare but aggressive papillary thyroid carcinoma (PTC) variant, the genetic changes of hobnail variant of PTC (HVPTC) are still unclear.

    Results: The prevalence of HVPTC was 1.69% (18/1062) of all PTC diagnosed in our cohort. Read More

    Comorbidities of rheumatoid arthritis: Results from the Korean National Health and Nutrition Examination Survey.
    PLoS One 2017 19;12(4):e0176260. Epub 2017 Apr 19.
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
    This study aimed to evaluate the prevalence of comorbidities in patients with rheumatoid arthritis (RA) compared with the non-RA population. The 2010-2012 Korea National Health and Nutrition Examination Survey (KNHANES), which assesses the general health status of populations in South Korea using interviews and basic health assessment, was analyzed retrospectively. Weighted prevalence and odds ratio (OR) of comorbidities were analyzed in patients with RA compared with the non-RA population. Read More

    Cranial irradiation in childhood mimicking neurofibromatosis type II.
    Am J Med Genet A 2017 Apr 19. Epub 2017 Apr 19.
    The Gilbert Israeli Neurofibromatosis Center, Tel-Aviv Medical Center, Tel-Aviv, Israel.
    Neurofibromatosis type II (NF2) is a genetic disease characterized by bilateral vestibular schwannomas (VS) and other nerve system tumors. However, such tumors may be associated with environmental, rather than a genetic, etiology. Individuals fulfilling the clinical criteria of NF2 who had been treated by head ionized irradiation at a young age were compared for disease characteristics and molecular analysis with non-irradiated sporadic NF2 cases. Read More

    Surgical treatment in Paget's disease with invasive ductal carcinoma: an observational study based on SEER.
    Sci Rep 2017 Apr 19;7:45510. Epub 2017 Apr 19.
    Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, P. R. China.
    The aim is to analyse the clinical presentation, treatment and outcomes in patients with Paget's disease with invasive ductal carcinoma (PD-IDC), with special emphasis on the role of surgical treatment. Using data obtained by the Surveillance, Epidemiology, and End Results (SEER) program from 2010-2013, we investigated the differences in characteristics, overall survival (OS), and breast cancer-specific mortality (BCSM) between patients with PD-IDC and those with invasive ductal carcinoma (IDC). Compared with IDC group, patients with PD-IDC had a better prognosis and lower mortality in adjusted analyses. Read More

    The Frequency of Incidental Findings and Subsequent Evaluation in Low-Dose CT Scans for Lung Cancer Screening.
    Ann Am Thorac Soc 2017 Apr 19. Epub 2017 Apr 19.
    Cleveland Clinic, Cleveland, Ohio, United States ;
    Rationale: The USPSTF recommends lung cancer screening with low-dose chest CT scans (LDCT) for a well-defined high-risk population. Data on the frequency and impact of incidental findings on LDCT scans performed within a centralized lung cancer screening program has not been reported.

    Objectives: Previous studies have reported IFs in the setting of clinical trials. Read More

    Growth characteristics and endocrine abnormalities in 22q11.2 deletion syndrome.
    Am J Med Genet A 2017 May 16;173(5):1301-1308. Epub 2017 Feb 16.
    Pediatric Endocrinology and Diabetes Unit, The Edmond and Lilly Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel.
    22q11.2 deletion syndrome (22q11.2DS) has a wide range of clinical features including endocrine abnormalities. Read More

    Genetics of Thyroid-Stimulating Hormone Receptor-Relevance for Autoimmune Thyroid Disease.
    Front Endocrinol (Lausanne) 2017 3;8:57. Epub 2017 Apr 3.
    Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
    Production of thyroid-stimulating hormone receptor (TSHR) antibodies represents the hallmark of Graves' disease (GD) pathogenesis. Thus, for more than two decades the TSHR gene has been at the center of studies intended to elucidate its contribution to disease pathology. The advent of genome-wide association technology allowed to establish a strong association of the TSHR gene with GD. Read More

    Preconception management of thyroid disorders.
    J Pak Med Assoc 2017 Apr;67(4):645-647
    Department of Endocrinology, Bharti Hospital, Karnal, India.
    Thyroid function is closely interlinked with pregnancy. Maternal and foetal outcomes can be improved if optimal thyroid function is achieved, and maintained prior to conception. This needs a systematic approach which includes rational screening, appropriate management, and pragmatic counseling. Read More

    Heart, lipids and hormones.
    Endocr Connect 2017 Apr 18. Epub 2017 Apr 18.
    M Krebs, Internal Medicine III, Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria
    Cardiovascular disease is the leading cause of death in general population. Besides well known risk factors like hypertension, impaired glucose tolerance and dyslipidemia, growing evidence suggests that also hormonal changes in various endocrine diseases impact cardiac morphology and function. Recent studies highlight the importance of ectopic intracellular myocardial and pericardial lipid deposition, since even slight changes of these fat depots are associated with alterations in cardiac performance. Read More

    Pilot survey of the health of Massachusetts dentists.
    J Investig Clin Dent 2017 Apr 16. Epub 2017 Apr 16.
    Department of Orthodontics, University of Iowa, Iowa City, IA, USA.
    Aim: Dentistry is a career that is very rewarding because of the direct opportunity to deliver essential health services to patients in need. Dentistry is also very demanding; mentally, physically, and even emotionally. Little is known about the health of dentists and how it compares to the health of the general population. Read More

    Solid Papillary Breast Carcinomas Resembling the Tall Cell Variant of Papillary Thyroid Neoplasms: A Unique Invasive Tumor With Indolent Behavior.
    Am J Surg Pathol 2017 Apr 17. Epub 2017 Apr 17.
    *Department of Biomedical and Neuromotor Sciences, Section of Pathology "M. Malpighi," University of Bologna, Bologna ∥Department of Pathology, CDI, Milano, Italy †Pathology Unit, Laboratories Dr. Macedo Dias, Porto, Portugal ‡Department of Pathology, Bács-Kiskun County Teaching Hospital, Kecskemét, Hungary §Department of Histopathology, Nottingham City Hospital, Nottingham, United Kingdom.
    Thirteen cases of invasive solid papillary breast carcinomas resembling the tall cell variant of papillary thyroid neoplasms (BPTC) are reported here. Some cases had long-term follow-up. BPTC is a special type of primary breast neoplasm showing a triple-negative profile but low aggressive potential. Read More

    Late 124I PET/CT Uptake Measurement-Assessment of Appropriate Examination Protocol in Benign Thyroid Diseases.
    Clin Nucl Med 2017 Apr 17. Epub 2017 Apr 17.
    From the Clinic of Nuclear Medicine, Jena University Hospital, Jena, Germany.
    Purpose: This study aimed at investigating the performance of late I PET/CT for radioiodine uptake (RAIU) measurement at 336 hours after administration in patients with benign thyroid diseases requiring radioiodine therapy. Special attention was paid to the comparability of I uptake (I-RAIU) to the clinical standard (I-RAIU, probe measurement). Considering cost aspects, we sought to establish an economically reasonable examination protocol based on scan duration and administered activity. Read More

    Plurihormonal cells of normal anterior pituitary: Facts and conclusions.
    Oncotarget 2017 Mar 23. Epub 2017 Mar 23.
    Ott Research Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, 199034, Russian Federation.
    Introduction: plurihormonality of pituitary adenomas is an ability of adenoma cells to produce more than one hormone. After the immunohistochemical analysis had become a routine part of the morphological study, a great number of adenomas appeared to be multihormonal in actual practice. We hypothesize that the same cells of a normal pituitary gland releases several hormones simultaneously. Read More

    Case 241: Hemiparkinsonism- Hemiatrophy-SPECT with (99m)Tc TRODAT-1 and Muscle MR Imaging Abnormalities.
    Radiology 2017 May;283(2):613-619
    From the Department of Internal Medicine, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil (T.C.V.); Department of Neurology (F.C.d.L.P., J.L.P., O.G.B.) and Department of Psychiatry, Laboratório Interdisciplinar de Neurociências Clínicas (LiNC) (M.A.d.R., I.R.B., R.A.B.), Universidade Federal de São Paulo, R. Sena Madureira 1500, Vila Clementino, São Paulo, SP 04021-001, Brazil; and Delboni Auriemo, Diagnósticos da América SA, São Paulo, Brazil (R.L.M.R., R.A.M.).
    History A 43-year-old right-handed man presented with a history of progressive mild left-sided weakness and slowness of movements. Symptoms began 4 years earlier, and the patient noticed a progressive decline in his daily routine due to gait difficulties in the past year. There was no history of head trauma, surgery, drug therapy, smoking, or alcohol abuse, nor was there any relevant family history. Read More

    The G534E variant in HABP2 is not associated with increased risk of familial nonmedullary thyroid cancer in Brazilian Kindreds.
    Clin Endocrinol (Oxf) 2017 Apr 18. Epub 2017 Apr 18.
    Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
    Familial nonmedullary thyroid cancer (FNMTC) encompasses a heterogeneous group of diseases that includes both syndromic and nonsyndromic associated tumours. The syndromic group is characterized by a preponderance of nonthyroidal tumours and is associated with Mendelian cancer syndromes. Nonsyndromic groups, which account for 95% of the cases, are characterized by a significantly increased rate of benign or malignant thyroid tumours of follicular-cell origin in the same family and are not associated with other Mendelian cancer syndromes. Read More

    A Retrospective Study on the Association between Thyroid Autoantibodies with β2-glycoprotein and Cardiolipin Antibodies in Recurrent Miscarriage.
    Iran J Allergy Asthma Immunol 2017 Feb;16(1):72-76
    Clinical Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Austria.
    Etiologic factors for recurrent miscarriage (RM) include autoimmune diseases, the most frequently antiphospholipid syndrome and thyroiditis. Some women who suffer from RM might also have an altered immune system. We aimed to evaluate possible associations between anti-thyroid and anti-phospholipid antibodies in women with RM. Read More

    Applying a systems approach to thyroid physiology: Looking at the whole with a mitochondrial perspective instead of judging single TSH values or why we should know more about mitochondria to understand metabolism.
    BBA Clin 2017 Jun 4;7:127-140. Epub 2017 Apr 4.
    WOMED, Karl-Kapferer-Strasse 5, AT-6020 Innsbruck, Austria.
    Classical thinking in endocrine physiology squeezes our diagnostic handling into a simple negative feedback mechanism with a controller and a controlled variable. In the case of the thyroid this is reduced to TSH and fT3 and fT4, respectively. The setting of this tight notion has no free space for any additions. Read More

    Characterization and risk estimate of cancer in patients with primary Sjögren syndrome.
    J Hematol Oncol 2017 Apr 17;10(1):90. Epub 2017 Apr 17.
    Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, ICMiD, Hospital Clínic, Barcelona, Spain.
    Background: The purpose of this study is to characterize the risk of cancer in a large cohort of patients with primary Sjögren syndrome (SjS).

    Methods: We had analyzed the development of cancer in 1300 consecutive patients fulfilling the 2002 SjS classification criteria. The baseline clinical and immunological characteristics and systemic activity (ESSDAI scores) were assessed at diagnosis as predictors of cancer using Cox proportional hazards regression analysis adjusted for age at diagnosis and gender. Read More

    A nation-wide multicenter 10-year (1999-2008) retrospective study of chemotherapy in Chinese breast cancer patients.
    Oncotarget 2017 Mar 22. Epub 2017 Mar 22.
    Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, China.
    Little information is available on the evolvement of chemotherapeutic regimens administered to Chinese females with breast cancer. We retrospectively analyzed demographic, pathological and chemotherapeutic data of 4211 breast cancer patients, who were randomly selected from representative hospitals of 7 traditional areas in China between 1999 and 2008. A total of 3271 cases (77. Read More

    Genome-wide association study of high-altitude pulmonary edema in a Han Chinese population.
    Oncotarget 2017 Mar 18. Epub 2017 Mar 18.
    Center of Altitude Disease, General Hospital of Tibet Military Area Command, Lhasa 850003, China.
    A two-stage genome-wide association study (GWAS) was performed to identify and analyze genes and single nucleotide polymorphisms (SNPs) associated with high-altitude pulmonary edema (HAPE) in a Han Chinese patient population. In the first stage, DNA samples from 68 patients with recurrent HAPE were scanned using Affymetrix SNP Array 6.0 Chips, and allele frequencies were compared to those of 84 HapMap CHB samples to identify candidate SNPs. Read More

    Patients with subclinical hypothyroidism before 20 weeks of pregnancy have a higher risk of miscarriage: A systematic review and meta-analysis.
    PLoS One 2017 17;12(4):e0175708. Epub 2017 Apr 17.
    The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases, Department of Endocrinology and Metabolism, The First Hospital of China Medical University, Shenyang, China.
    Objective: To evaluate the relationship between subclinical hypothyroidism (SCH) and the risk of miscarriage before 20 weeks of pregnancy.

    Methods: Literature databases were searched, including the PubMed, Web of Science, Embase and Cochrane databases, from January 1, 1980, to December 31, 2015. The following search terms were used: subclinical hypothyroidism, hypothyroidism, thyroid dysfunction, thyroid hypofunction, subclinical thyroid disease, thyroid dysfunction, pregnancy loss, abortion and miscarriage. Read More

    Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance.
    Oncogene 2017 Apr 17. Epub 2017 Apr 17.
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
    High CD44 expression is associated with enhanced malignant potential in esophageal squamous cell carcinoma (ESCC), among the deadliest of all human carcinomas. Although alterations in autophagy and CD44 expression are associated with poor patient outcomes in various cancer types, the relationship between autophagy and cells with high CD44 expression remains incompletely understood. In transformed oesophageal keratinocytes, CD44(Low)-CD24(High) (CD44L) cells give rise to CD44(High)-CD24(-/Low) (CD44H) cells via epithelial-mesenchymal transition (EMT) in response to transforming growth factor (TGF)-β. Read More

    Comparative evaluation of iodine-131 metaiodobenzylguanidine and 18-fluorodeoxyglucose positron emission tomography in assessing neural crest tumors: Will they play a complementary role?
    South Asian J Cancer 2017 Jan-Mar;6(1):31-34
    Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre, Mumbai, Maharashtra, India.
    Background: 18-Fluorodeoxyglucose positron emission tomography (FDG-PET) has established a role in the evaluation of several malignancies. However, its precise clinical role in the neural crest cell tumors continues to evolve.

    Purpose: The purpose of this study was to compare iodine-131 metaiodobenzylguanidine ((131)I-MIBG) and FDG-PET of head to head in patients with neural crest tumors both qualitatively and semiquantitatively and to determine their clinical utility in disease status evaluation and further management. Read More

    25-Hydroxyvitamin D serum level in Hashimoto's thyroiditis, but not Graves' disease is relatively deficient.
    Endocr J 2017 Apr 11. Epub 2017 Apr 11.
    Department of Endocrinology, Fifth People's Hospital of Shanghai Fudan University, Fudan University, Shanghai 200240, China.
    Vitamin D is a modulator of both the innate and adaptive immune system. As vitamin D deficiency was a risk factor for some autoimmune diseases, we aimed to evaluate the serum vitamin D levels in autoimmune thyroid diseases (AITD) including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) and investigated the association between serum vitamin D levels and AITD. 175 AITD patients including 51 GD, 61 euthyroid HT (mild HT), 63 euthyroid HT patients with hypothyroidism receiving hormone therapy (treated HT) were recruited from the outpatient department. Read More

    Appraising the holistic value of Lenvatinib for radio-iodine refractory differentiated thyroid cancer: A multi-country study applying pragmatic MCDA.
    BMC Cancer 2017 Apr 17;17(1):272. Epub 2017 Apr 17.
    LASER Analytica, Montreal, Quebec, Canada.
    Background: The objective of the study was to reveal through pragmatic MCDA (EVIDEM) the contribution of a broad range of criteria to the value of the orphan drug lenvatinib for radioiodine refractory differentiated thyroid cancer (RR-DTC) in country-specific contexts.

    Methods: The study was designed to enable comprehensive appraisal (12 quantitative, 7 qualitative criteria) in the current disease context (watchful waiting, sorafenib) of France, Italy and Spain. Data on the value of lenvatinib was collected from diverse stakeholders during country-specific panels and included: criteria weights (individual and social values); performance scores (judgments on evidence-collected through MCDA systematic review); qualitative impacts of contextual criteria; and verbal and written insights structured by criteria. Read More

    Expression of MRP1 and ABCG2 is associated with adverse clinical outcomes of the papillary thyroid carcinoma with a solid component.
    Hum Pathol 2017 Apr 11. Epub 2017 Apr 11.
    Department of Diagnostic Pathology, Nippon Medical School Hospital, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan; Department of Integrated Diagnostic Pathology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
    Solid variant of papillary thyroid carcinoma is characterized by a solid component (SC) retaining classical cytological features of papillary thyroid carcinoma (PTC). Despite some controversies, PTC cases with SC (PTCSC) have poor prognosis compared to well-differentiated PTC. We investigated if cancer stem cells (CSC) may have a role in pathogenesis of PTCSC. Read More

    Locally invasive thyroid cancer: options for a treatment.
    Updates Surg 2017 Apr 13. Epub 2017 Apr 13.
    Thoracic Surgery Unit, University of Perugia Medical School, Loc. Sant'Andrea delle Fratte, 06134, Perugia, Italy.
    Local invasion to neighbor organs by thyroid cancer is an important prognosticator and requires different therapeutic approach. Which one is the possible best treatment option and results are evaluated in this study. A single-institution experience in thyroid cancer invading the airway is evaluated retrospectively (1990-2016). Read More

    Surgical management of medullary thyroid carcinoma.
    Updates Surg 2017 Apr 13. Epub 2017 Apr 13.
    Section of Endocrine Surgery, Department of Surgery, Duke University School of Medicine, DUMC 2945, Durham, NC, 27710, USA.
    Medullary thyroid cancer (MTC) is a malignant tumor of the parafollicular C cells of the thyroid and comprises only 1-2% of all thyroid cancer cases. Unlike most differentiated thyroid cancer, MTC is associated with a mean survival of 8.6 years and accounts for a disproportionate 8. Read More

    Comorbidity of chronic spontaneous urticaria and autoimmune thyroid diseases: a systematic review.
    Allergy 2017 Apr 13. Epub 2017 Apr 13.
    Charité - Universitätsmedizin Berlin, Department of Dermatology and Allergy, Berlin, Germany.
    Chronic spontaneous urticaria (CSU) patients are widely held to often have other autoimmune disorders, including autoimmune thyroid disease. Here, we systematically evaluated the literature on the prevalence of thyroid autoimmunity in CSU and vice versa. There is a strong link between CSU and elevated levels of IgG anti-thyroid autoantibodies (AAbs), with most of a large number of studies reporting rates of ≥10%. Read More

    Thyroid Hormone Economy in the Perinatal Mouse Brain: Implications for Cerebral Cortex Development.
    Cereb Cortex 2017 Apr 12:1-11. Epub 2017 Apr 12.
    Department of Endocrine and Nervous System Pathophysiology, Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), E-28029 Madrid, Spain.
    Thyroid hormones (THs, T4 and the transcriptionally active hormone T3) play an essential role in neurodevelopment; however, the mechanisms underlying T3 brain delivery during mice fetal development are not well known. This work has explored the sources of brain T3 during mice fetal development using biochemical, anatomical, and molecular approaches. The findings revealed that during late gestation, a large amount of fetal brain T4 is of maternal origin. Read More

    Subclinical hypothyroidism: Should we treat?
    Post Reprod Health 2017 Jan 1:2053369117705058. Epub 2017 Jan 1.
    1 Department of Endocrinology, Royal Devon & Exeter Hospital Foundation Trust, Exeter, UK.
    Subclinical hypothyroidism (also known as compensated hypothyroidism or mild hypothyroidism) is a condition associated with a raised serum concentration of thyroid stimulating hormone (TSH) but a normal serum free thyroxine (FT4). It is common, affecting about 10% of women above the age of 55 years. Autoimmunity is the commonest cause of subclinical hypothyroidism. Read More

    A Study of salt and fat Consumption pattern in Regional Indian diet among hypertensive and dyslipidemic PaTients - SCRIPT study.
    J Assoc Physicians India 2016 Dec;64(12):47-54
    Abbott Healthcare Pvt. Ltd., Mumbai, Maharashtra.
    Background: Cardiovascular diseases are leading cause of mortality and morbidity. There is an increasing prevalence of hypertension and dyslipidemia due to globalization and adoption of westernized dietary habits in India. These transitions are manifest in dietary patterns and health outcomes. Read More

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