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    miR-204 regulates the biological behavior of breast cancer MCF-7 cells by directly targeting FOXA1.
    Oncol Rep 2017 May 16. Epub 2017 May 16.
    Department of Pathology, The First Affiiated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
    MicroRNAs (miRNAs) are short, non-protein-coding RNAs and transcripts that are 18-24 nt in length. miR-204 was first identified as an anti-oncogene and is reported to be downregulated in non-small cell lung cancer, glioma, gastric and thyroid cancer. Recent studies have proposed that a low level of miR-204 expression is associated with tumor progression and disease outcome in breast cancer. Read More

    HASHIMOTO'S THYROIDITIS AND VESTIBULAR DYSFUNCTION.
    Endocr Pract 2017 May 23. Epub 2017 May 23.
    Endocrinology Clinic, Internal Medicine Department, Institut Jules Bordet-Comprehensive Cancer Center, Université Libre de Bruxelles, Brussels, Belgium.
    The aim of this review was to analyze the existing literature concerning the relationship between Hashimoto's thyroiditis (HT) and vestibular dysfunction.

    Methods: We used electronic databases (PubMed, EMBASE, Cochrane Library) to search and collect all published articles about association between HT and vestibular disorders.

    Results: Several observational and retrospective studies have postulated a relationship of thyroid autoimmunity and vestibular disorders. Read More

    Hypothyroidism in hospitalized elderly patients: a sign of worse prognosis.
    J Endocrinol Invest 2017 May 22. Epub 2017 May 22.
    Endocrinology Department, Cesar Milstein Hospital, 951 La Rioja St, 1221, Buenos Aires, Argentina.
    Purpose: Overt hypothyroidism has adverse clinical consequences and might worsen prognosis in critically ill elderly patients. However, the difficult interpretation of thyroid function tests (TFT) due to non-thyroidal illness (NTI) has led to discouragement of screening for thyroid dysfunction. Our aim was to determine the prevalence of TFT compatible with hypothyroidism and to study its influence on mortality among hospitalized elderly patients. Read More

    Reactivity to Novel Autoantigens in Patients with Coexisting Central Nervous System Demyelinating Disease and Autoimmune Thyroid Disease.
    Front Immunol 2017 8;8:514. Epub 2017 May 8.
    Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
    Several lines of evidence suggest a definite and unique link between CNS demyelinating diseases and autoimmune thyroid disease (AITD). The aim of the current study was to systematically compare the clinical and laboratory features of patients with coexistent AITD and CNS demyelinating disease with those of patients with just CNS demyelinating disease. Forty-four patients with coexisting CNS demyelinating disease and AITD were identified and their clinical and radiological features were recorded. Read More

    U.S. Food and Drug Administration Approval Summary: Pembrolizumab for the Treatment of Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma with Disease Progression on or After Platinum-Containing Chemotherapy.
    Oncologist 2017 May 22. Epub 2017 May 22.
    Office of Hematology and Oncology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
    On August 5, 2016, the U.S. Food and Drug Administration granted accelerated approval to pembrolizumab (KEYTRUDA injection, Merck Sharp & Dohme Corp. Read More

    Risk of hypothyroidism among patients with nasopharyngeal carcinoma treated with radiation therapy: A Population-Based Cohort Study.
    Radiother Oncol 2017 May 19. Epub 2017 May 19.
    Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan; Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan. Electronic address:
    Background And Purpose: This study aimed to assess the incidence and risk of hypothyroidism among patients with nasopharyngeal carcinoma (NPC) after radiation therapy (RT).

    Material And Methods: We identified 14,893 NPC patients and 16,105 other head and neck cancer (HNC) patients treated with RT without thyroidectomy from the National Health Insurance Research Database in Taiwan between 2000 and 2011. Each NPC patient was randomly frequency-matched with four individuals without NPC by age, sex, and index year. Read More

    Oxidative stress and metabolic syndrome: Effects of a natural antioxidants enriched diet on insulin resistance.
    Clin Nutr ESPEN 2015 Apr 19;10(2):e52-e60. Epub 2015 Mar 19.
    Institute of Biochemistry and Clinical Biochemistry, Catholic University of the Sacred Heart, Largo Agostino Gemelli, 8, 00168 Rome, Italy. Electronic address:
    Background & Aims: Oxidative stress (OS) could play a role in metabolic syndrome-related manifestations contributing to insulin resistance (IR). The aim of the present study was to gain insight the relationships between OS, IR and other hormones involved in caloric balance, explaining the effects of a natural antioxidant-enriched diet in patients affected by metabolic syndrome.

    Methods: We investigated the effects of dietary antioxidants on IR, studying 53 obese (20 males and 33 females, 18-66 years old, BMI 36. Read More

    Racial Differences in 20-Year Cardiovascular Mortality Risk Among Childhood and Young Adult Cancer Survivors.
    J Adolesc Young Adult Oncol 2017 May 22. Epub 2017 May 22.
    2 Department of Clinical Cancer Prevention, The University of Texas M.D. Anderson Cancer Center , Houston, Texas.
    Purpose: Whether cardiovascular disease (CVD) risk differs according to race and cancer type among survivors of childhood or young adulthood cancers is unknown.

    Methods: Data from the years 1973-2011 were analyzed using the Surveillance, Epidemiology, and End Results (SEER) registries. Cases were categorized by ICD-0-3/WHO 2008 Adolescent and Young Adult classification. Read More

    [SERUM THYROGLOBULIN LEVELS AND ESTIMATED IODINE INTAKE IN ADULTS EXPOSED TO IODINE‑DILUTED DESALINATED DRINKING WATER].
    Harefuah 2016 Aug;155(8):470-474
    Department of Internal Medicine C, Barzilai Medical Center Ashkelon, Israel.
    Aims: The aim of this study was to describe thyroglobulin levels and iodine intake estimations in a convenience sample of Israeli adults without TD in the Ashkelon District, where SWRO desalination has become the major source of drinking water.

    Background: Iodine deficiency (ID) is a significant risk factor for thyroid disease (TD). Recently, there were increases in both selfreported use of TD medication among Israeli adults and the national use of sea water reverse osmosis (SWRO) desalinated water. Read More

    [PAPILLARY THYROID CARCINOMA TREATMENT - IS THE PENDULUM SHIFTING?]
    Harefuah 2016 Aug;155(8):511-515
    Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petach Tikva, Israel.
    Introduction: The incidence of papillary thyroid carcinoma has been on the rise in the past few decades while the disease specific mortality remains stable. During prophylactic central neck dissection (level 6), an average of 60% positive occult lymph nodes metastasis are found, hence the justification for performing a prophylactic central neck dissection. The opponents for performing neck dissection claim that the disease specific mortality is low regardless of the operation and that adding a neck dissection will, significantly, increase surgical morbidity. Read More

    Evolution, immunity and the emergence of brain superautoantigens.
    F1000Res 2017 21;6:171. Epub 2017 Feb 21.
    Bank of Tissues and Cells, Lyon University Hospital (Hospices Civils de Lyon), CarMeN Laboratory, INSERM 1060, INRA 1397, INSA Lyon, Université Claude Bernard Lyon-1, Lyon, F-69000, France.
    While some autoimmune disorders remain extremely rare, others largely predominate the epidemiology of human autoimmunity. Notably, these include psoriasis, diabetes, vitiligo, thyroiditis, rheumatoid arthritis and multiple sclerosis. Thus, despite the quasi-infinite number of "self" antigens that could theoretically trigger autoimmune responses, only a limited set of antigens, referred here as superautoantigens, induce pathogenic adaptive responses. Read More

    Aggressiveness of the tall cell variant of papillary thyroid carcinoma is independent of the tumor size and patient age.
    Oncol Lett 2017 May 29;13(5):3501-3507. Epub 2017 Mar 29.
    Department of Anatomic Pathology, Clinical University Hospital, Faculty of Medicine, Galician Healthcare Service, University of Santiago de Compostela, Santiago de Compostela 15706, Spain.
    The tall cell variant (TCV) of papillary thyroid carcinoma (PTC) is characterized by tall columnar cells with a height of at least three times their width. TCV usually presents at an older age, has a larger size and exhibits more extrathyroidal extension and metastases than classical PTC. The current study compared TCV with the classical and follicular variants (CaFVs) of PTC to determine if, irrespective of the age at diagnosis and tumor size, TCV is more aggressive than its classical and follicular counterparts. Read More

    Antithyroid Drug Therapy for Graves' Disease and Implications for Recurrence.
    Int J Endocrinol 2017 25;2017:3813540. Epub 2017 Apr 25.
    Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
    Graves' disease (GD) is the most common cause of hyperthyroidism worldwide. Current therapeutic options for GD include antithyroid drugs (ATD), radioactive iodine, and thyroidectomy. ATD treatment is generally well accepted by patients and clinicians due to some advantages including normalizing thyroid function in a short time, hardly causing hypothyroidism, and ameliorating immune disorder while avoiding radiation exposure and invasive procedures. Read More

    Sagittal Plane Kinematics of the Jaw and Hyolingual Apparatus During Swallowing in Macaca mulatta.
    Dysphagia 2017 May 20. Epub 2017 May 20.
    Department of Organismal Biology and Anatomy, University of Chicago, 1025 E 57th St. Culver Rm 206, Chicago, IL, 60637, USA.
    Studies of mechanisms of feeding behavior are important in a society where aging- and disease-related feeding disorders are increasingly prevalent. It is important to evaluate the clinical relevance of animal models of the disease and the control. Our present study quantifies macaque hyolingual and jaw kinematics around swallowing cycles to determine the extent to which macaque swallowing resembles that of humans. Read More

    Tall cell and diffuse sclerosing variants of papillary thyroid cancer: outcome and predicting value of risk stratification methods.
    J Endocrinol Invest 2017 May 20. Epub 2017 May 20.
    Endocrinology, Department of Clinical and Experimental Medicine, Garibaldi-Nesima Medical Center, University of Catania, Via Palermo 636, 95122, Catania, Italy.
    Purpose: Tall cell (TCV) and diffuse sclerosing (DSV) variants are aggressive variants of papillary thyroid cancer (PTC). We compared the risk of recurrent/persistent disease in patients with TCV, DSV and classical PTC (cPTC) and evaluated the prognostic accuracy of initial vs. ongoing risk stratification. Read More

    TR2 and TR4 Orphan Nuclear Receptors: An Overview.
    Curr Top Dev Biol 2017 5;125:357-373. Epub 2017 Apr 5.
    George Whipple Lab for Cancer Research, The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, United States; Sex Hormone Research Center, China Medical University/Hospital, Taichung, Taiwan. Electronic address:
    Testicular nuclear receptors 2 and 4 (TR2, TR4), also known as NR2C1 and NR2C2, belong to the nuclear receptor superfamily and were first cloned in 1989 and 1994, respectively. Although classified as orphan receptors, several natural molecules, their metabolites, and synthetic compounds including polyunsaturated fatty acids (PUFAs), PUFA metabolites 13-hydroxyoctadecadienoic acid, 15-hydroxyeicosatetraenoic acid, and the antidiabetic drug thiazolidinediones can transactivate TR4. Importantly, many of these ligands/activators can also transactivate peroxisome proliferator-activated receptor gamma (PPARγ), also known as NR1C3 nuclear receptor. Read More

    COUP-TF Genes, Human Diseases, and the Development of the Central Nervous System in Murine Models.
    Curr Top Dev Biol 2017 18;125:275-301. Epub 2017 Jan 18.
    Institute of Life Science, Nanchang University, Nanchang, Jiangxi, China. Electronic address:
    COUP-TFI and -TFII are members of the steroid/thyroid nuclear receptor superfamily. Recent clinical studies reveal that COUP-TFI gene mutations are associated with Bosch-Boonstra-Schaaf optic atrophy syndrome displaying symptoms of optic atrophy, intellectual disability, hypotonia, seizure, autism spectrum disorders, oromotor dysfunction, thin corpus callosum, or hearing defects, and COUP-TFII gene mutations lead to congenital heart defects and/or congenital diaphragmatic hernia with developmental delay and mental defects. In this review, we first describe the functions of COUP-TF genes in the morphogenesis of mouse forebrain including cerebral cortex, hippocampus, amygdala complex, hypothalamus, and cortical interneuron. Read More

    Cytogenetic biodosimetry and dose-rate effect after radioiodine therapy for thyroid cancer.
    Radiat Environ Biophys 2017 May 19. Epub 2017 May 19.
    Department of Radiation Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Japan.
    This study set out to investigate chromosomal damage in peripheral blood lymphocytes of thyroid cancer patients receiving (131)I for thyroid remnant ablation or treatment of metastatic disease. The observed chromosomal damage was further converted to the estimates of whole-body dose to project the adverse side effects. Chromosomal aberration analysis was performed in 24 patients treated for the first time or after multiple courses. Read More

    Modeling Psychomotor Retardation using iPSCs from MCT8-Deficient Patients Indicates a Prominent Role for the Blood-Brain Barrier.
    Cell Stem Cell 2017 May 8. Epub 2017 May 8.
    The Board of Governors Regenerative Medicine Institute and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address:
    Inactivating mutations in the thyroid hormone (TH) transporter Monocarboxylate transporter 8 (MCT8) cause severe psychomotor retardation in children. Animal models do not reflect the biology of the human disease. Using patient-specific induced pluripotent stem cells (iPSCs), we generated MCT8-deficient neural cells that showed normal TH-dependent neuronal properties and maturation. Read More

    An Unusual Case of Sudden Death: Is There a Relationship Between Thyroid Disorders and Fatal Pulmonary Thromboembolism? A Case Report and Review of Literature.
    Am J Forensic Med Pathol 2017 May 19. Epub 2017 May 19.
    From the *Institute of Legal Medicine, University "La Sapienza," Rome; and †Institute of Legal Medicine, University "Magna Graecia," Catanzaro, Italy.
    In adults, the most common cause of sudden death is coronary heart disease or defects in the cardiac conduction system; however, there are many cases of sudden death occurring from other causes such as fatal pulmonary thromboembolism. Several risk factors are recognized, including hospitalization, surgery, obesity, pregnancy, the use of oral contraceptives, traumatic fractures, and genetic conditions, which cause hypercoagulable states such as factor V Leiden mutations. Although many risk factors have been identified, the mortality rate is still high. Read More

    First in-human radiation dosimetry of (68)Ga-NODAGA-RGDyK.
    EJNMMI Res 2017 Dec 18;7(1):43. Epub 2017 May 18.
    Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland.
    Background: Integrin-targeting radiopharmaceuticals have potential broad applications, spanning from cancer theranostics to cardiovascular diseases. We have previously reported preclinical dosimetry results of (68)Ga-NODAGA-RGDyK in mice. This study presents the first human dosimetry of (68)Ga-NODAGA-RGDyK in the five consecutive patients included in a clinical imaging protocol of carotid atherosclerotic plaques. Read More

    Hashimoto's thyroiditis associated with thyroid adenoma with Hürthle cells - case report.
    Rom J Morphol Embryol 2017 ;58(1):241-248
    Department of Endocrinology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;
    Chronic thyroiditis may present a focal lesion, often-palpable abnormality, simulating nodular disease. The number and morphology of the Hürthle cells (HC) vary in the thyroid aspirate. Distinguishing between neoplastic and non-neoplastic HC lesions is difficult when using the fine-needle aspiration cytology (FNAC). Read More

    High expression of PLA2G16 is associated with a better prognosis in HER2-positive breast cancer.
    J Thorac Dis 2017 Apr;9(4):1002-1011
    Department of Cancer Stem Cell, Dalian Medical University, Dalian 116000, China.
    Background: PLA2G16 functions as a phosphatase in metabolism and its abnormal expression is closely associated with tumor progression. The aim of this study is to investigate the prognosis value of PLA2G16 in breast cancer.

    Methods: A tissue microarray including 200 invasive ductal carcinoma specimens was constructed. Read More

    Association of vitamin D insufficiency/deficiency with thyroid artery Doppler ultrasonography in patients with Hashimoto thyroiditis.
    Pak J Med Sci 2017 Mar-Apr;33(2):295-299
    Prof. Dr. Hakan Cinemre, Departments of Internal Medicine, Sakarya University School of Medicine, Sakarya, Turkey.
    Background & Objective: During the course of the autoimmune thyroid diseases, ultrasonography change parallel to histopathology. Vitamin D is associated with autoimmune diseases and thus can affect thyroid blood flow. Our aim was to investigate the relationship between vitamin D insufficiency/deficiency and thyroid hemodynamic indices in patients with Hashimoto thyroiditis. Read More

    Incidence of total hip or knee replacement due to osteoarthritis in relation to thyroid function: a prospective cohort study (The Nord-Trøndelag Health Study).
    BMC Musculoskelet Disord 2017 May 18;18(1):201. Epub 2017 May 18.
    Division of Orthopaedic Surgery, Oslo University Hospital, Oslo, Norway.
    Background: To study whether thyroid function was associated with risk of hip or knee replacement due to primary osteoarthritis.

    Methods: In a prospective cohort study, data from the second and third survey of the Nord-Trøndelag Health Study were linked to the Norwegian Arthroplasty Register in order to identify total hip or knee replacement as a result of primary osteoarthritis.

    Results: Among 37 891 participants without previously known thyroid disease we recorded 978 total hip replacements (THRs) and 538 total knee replacements (TKRs) during a median follow-up time of 15. Read More

    The Influence of the Manner of Performing the Thyroid Ultrasound Examination on the Reliability of the Assessment of the Thyroid Size in School-Aged Children.
    Horm Res Paediatr 2017 May 18. Epub 2017 May 18.
    Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland.
    Background/aims: Goitre incidence in school-aged children evaluated using ultrasonography is one of the essential indicators of iodine intake in a given area. The aim of the study was to examine what the difference is between the volume of the thyroid gland measured in the supine and sitting position and to determine the intra-observer, inter-observer, and inter-position variations.

    Methods: The survey was conducted among 87 children (56 girls and 31 boys aged 7-13 years, mean age 10. Read More

    Defining optimal health range for thyroid function based on the risk of cardiovascular disease.
    J Clin Endocrinol Metab 2017 May 17. Epub 2017 May 17.
    Department of Epidemiology and.
    Context: Reference ranges of thyroid stimulating hormone (TSH) and free thyroxine (FT4) are defined by their distribution in apparently healthy populations, (2.5th and 97.5th percentiles) irrespective of disease risk and used as cut-offs for defining and clinically managing thyroid dysfunction. Read More

    Management and outcome of clinically evident neck recurrence in patients with papillary thyroid cancer.
    Clin Endocrinol (Oxf) 2017 May 18. Epub 2017 May 18.
    Department of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center.
    Background: The aim of this study was to report our incidence of clinically evident neck recurrence, salvage neck management and subsequent outcomes in patients with papillary thyroid cancer. This is important to know so that patients with thyroid cancer can be properly councelled about the implications of recurrent disease and subsequent outcome.

    Methods: An institutional database of 3664 patients with thyroid cancer operated between 1986 and 2010 was reviewed. Read More

    Screening for lipoprotein receptor-related protein 4-, agrin-, and titin-antibodies and exploring the autoimmune spectrum in myasthenia gravis.
    J Neurol 2017 May 17. Epub 2017 May 17.
    Department of Neurology, RWTH Aachen University, Aachen, Germany.
    In autoimmune myasthenia gravis (MG), the identification of antibodies and characterization of serological subgroups is of great importance for diagnosis and management of the disease. Our aims were to study the frequency of antibodies against lipoprotein-related protein 4 (LRP4), agrin, and titin using the most recent techniques, and to characterize corresponding clinical features and autoimmune diseases (AID) in 100 MG-patients. The antibody frequencies in the 55 AChR-antibody positive patients were 7% LRP4, 5% agrin, 53% titin, and in the 45 AChR-antibody negative patients 2% MuSK, 2% LRP4, 2% agrin, and 27% titin. Read More

    Corrigendum: Increased Toll-Like Receptors Activity and TLR Ligands in Patients with Autoimmune Thyroid Diseases.
    Front Immunol 2017 15;8:551. Epub 2017 May 15.
    Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, China.
    [This corrects the article on p. 578 in vol. 7, PMID: 28018345. Read More

    Subacute Noninfective Inflammatory Encephalopathy: Our Experience and Diagnostic Problems.
    Indian J Psychol Med 2017 Mar-Apr;39(2):183-187
    Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
    Introduction: Immune dysregulation associated encephalopathies present with significant psychiatric manifestations and only a few soft neurological and general systemic features. They are generally resistant to treatment with psychiatric medications. Generalized orthostatic myoclonus and faciobrachial dystonic seizures are mistaken as Creutzfeldt-Jakob disease and subacute sclerosing panencephalitis. Read More

    Metabolomic analysis shows differential hepatic effects of T2 and T3 in rats after short-term feeding with high fat diet.
    Sci Rep 2017 May 17;7(1):2023. Epub 2017 May 17.
    Program of Cardiovascular and Metabolic Disorders, Duke-NUS Medical School Singapore8 College Road, 169857, Singapore, Singapore.
    Nonalcoholic fatty liver disease (NAFLD) is a major health problem worldwide, and is often associated with lipotoxic injury, defective mitochondrial function, and insulin resistance. Thyroid hormones (THs) are important regulators of hepatic lipid metabolism. Among the THs, diiodothyronine (T2) and triiodothyronine (T3) have shown promising results in lowering hepatic fat content in various models of NAFLD. Read More

    Functional polymorphisms affecting Th1 differentiation are associated with the severity of autoimmune thyroid diseases.
    Endocr J 2017 May 16. Epub 2017 May 16.
    Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
    The prognosis for autoimmune thyroid diseases (AITDs), such as Hashimoto's disease (HD) and Graves' disease (GD), varies among patients. Interleukin (IL)-12 and IL-18 also induce Th1 differentiation, and SOCS1 (Suppressor of cytokine signaling 1) and TIM-3 (T cell immunoglobulin and mucin domain-3) are known to be negative regulators of Th1 cells. To clarify the association of functional polymorphisms in the IL12, IL12Rβ1, IL18, SOCS1 and TIM3 genes with the intractability and severity of autoimmune thyroid disease (AITD), we genotyped these polymorphisms in 151 GD patients, including 61 patients with intractable GD and 51 patients with GD in remission, in 140 HD patients, including 59 patients with severe HD and 55 patients with mild HD, and in 74 healthy controls. Read More

    Retina and Nerve Fiber Layer Thickness in Eyes with Thyroid-Associated Ophthalmopathy.
    Isr Med Assoc J 2017 May;19(5):277-281
    Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Thyroid-associated ophthalmopathy (TAO) is an inflammatory disease that affects the thyroid gland and the eye orbit. Of patients with TAO, 3%-5% have severe sight-threatening disease due to optic neuropathy Optical coherence tomography (OCT), the non-invasive imaging technology that yields high-resolution cross-sectional images of the retina, provides qualitative and quantitative data on the retina.

    Objectives: To apply this technique to quantitatively assess retinal nerve fiber layer (RNFL) and macular ring thicknesses in healthy subjects and in patients with TAO to determine their relationship to the severity of the orbital disease. Read More

    Mitral valve vegetation diagnosed with oesophageal ultrasound with bronchoscope (EUS-B).
    BMJ Case Rep 2017 May 15;2017. Epub 2017 May 15.
    Department of Pulmonary and Critical Care Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
    Oesophageal ultrasound with bronchoscope (EUS-B) is designed to evaluate mediastinal structures. We describe a case of a 78-year-old woman who presented with altered mental status for 2 weeks. CT head revealed a subacute infarct in the right middle cerebral artery distribution. Read More

    Deleterious Effects From Occupational Exposure to Ethylene Thiourea in Pregnant Women.
    Workplace Health Saf 2017 May 1:2165079916687312. Epub 2017 May 1.
    1 Emory University.
    Human exposure to endocrine disrupting chemicals (EDCs) has become common as a result of widespread application of these chemicals to the food supply, environmental contamination, and occupational exposures (Caserta et al., 2011). However, relatively little is known about the effects of EDCs such as ethylene thiourea (ETU) in developing fetuses and the lasting implications of this disruption on human development from birth through adulthood. Read More

    An Analysis of Dynamic Pulmonary Functions of Hypothyroid Patients.
    J Clin Diagn Res 2017 Mar 1;11(3):CC10-CC12. Epub 2017 Mar 1.
    Professor and Head, Department of Physiology, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India.
    Introduction: Hypothyroidism is a silent epidemic of our times. In India, the prevalence of hypothyroidism is 11%. The effect of hypothyroidism on respiratory system is debatable with studies suggesting both obstructive and restrictive disease patterns. Read More

    Study of Serum Total PSA and Free PSA as an Oncological Marker in Breast Tumour.
    J Clin Diagn Res 2017 Mar 1;11(3):BC13-BC16. Epub 2017 Mar 1.
    Medical Superintendent, Department of Surgical Oncology, Dr. B. Borooah Cancer Institute, Guwahati, Assam, India.
    Introduction: Breast Cancer (BC) cases are rising alarmingly all over the world and India is not an exception. This rising trend is due to an increased age at first child birth, decreased breast feeding, and the changing lifestyle mostly in urban India. With the advent of more sensitive methodologies and research works in this field, it has been suggested that Prostate Specific Antigen (PSA) plays an important role in the pathogenesis of breast cancer besides other established tumour markers. Read More

    Practical Surgical Techniques for Lymphadenectomy Along the Right Recurrent Laryngeal Nerve During Thoracoscopic Esophagectomy in the Prone Position.
    Ann Surg Oncol 2017 May 16. Epub 2017 May 16.
    Division of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, Kobe, Hyogo, Japan.
    Background: In esophageal squamous cell cancer (SCC), lymphadenectomy along the right recurrent laryngeal nerve (RLN) is important for disease control. The metastatic rate was 33% and the 5-year overall survival rate of these patients was 33.3%,1 but the risk of RLN palsy increases. Read More

    PAPILLARY THYROID CANCER: THE GOOD AND BAD OF THE "GOOD CANCER".
    Thyroid 2017 May 16. Epub 2017 May 16.
    University of Wisconsin, Department of Surgery, Madison, Wisconsin, United States ;
    Background: Papillary thyroid cancer is often described as the "good cancer" because of its treatability and relatively favorable survival rates. We sought to characterize the thoughts of papillary thyroid cancer patients as they relate to having the "good cancer."

    Methods: This qualitative study included 31 papillary thyroid cancer patients enrolled in an ongoing randomized trial. Read More

    Anti-thyroglobulin antibodies do not significantly increase the risk of finding iodine avid metastases on post-radioactive iodine ablation scan in low-risk thyroid cancer patients.
    J Endocrinol Invest 2017 May 16. Epub 2017 May 16.
    Division of Endocrinology, Diabetes, and Metabolism, The Ohio State University Medical Center, The Ohio State University and Arthur G. James Cancer Center, 575 McCampbell Hall, 1581 Dodd Dr, Columbus, OH, 43210, USA.
    Objective: Post-operative thyroglobulin (Tg) levels can predict the likelihood of residual cancer, including distant metastases, thereby influencing postsurgical treatment strategies even in patients with low-risk disease. Circulating anti-thyroglobulin antibodies (anti-Tg Abs) interfere with Tg measurement preventing this clinical use. It is not known if the presence of anti-Tg Abs predicts metastatic disease on post-therapy scan in patients with low-risk disease or if they should influence the use or dose of I-131 therapy. Read More

    Follow-up of patients with thyroglobulin-antibodies: Rising Tg-Ab trend is a risk factor for recurrence of differentiated thyroid cancer.
    Endocr Res 2017 May 16:1-9. Epub 2017 May 16.
    a Department of Surgical Oncology and Endocrine Surgery , University Medical Center Utrecht , Utrecht , The Netherlands.
    Purpose: Differentiated thyroid cancer is the most common endocrine malignancy. Recurrences (5-20%) are the main reason for follow-up. Thyroglobulin (Tg) has proven to be an excellent disease marker, but thyroglobulin-antibodies (Tg-Ab) may interfere with Tg measurement, leading to over or underestimation. Read More

    A case of minimal change nephrotic syndrome with hypothyroidism deterioration.
    CEN Case Rep 2016 May 26;5(1):95-98. Epub 2015 Oct 26.
    Department of Pathology, Tachikawa Sogo Hospital, 1-16-15 Nishiki-cho, Tachikawa, Tokyo, Japan.
    A 73-year-old woman with Graves' disease underwent total thyroidectomy and was being treated with levothyroxine. She developed edema in the lower region of both legs 1 month before hospitalization. She had a high concentration of urine protein and was hospitalized for further assessment. Read More

    Juvenile nephronophthisis and dysthyroidism: a rare association.
    CEN Case Rep 2017 May 13;6(1):98-104. Epub 2017 Mar 13.
    Shahrak of Gharb (Qods) pathologic and genetic center, Tehran, Iran.
    Nephronophthisis, an autosomal recessive kidney disease, represents the most frequent genetic cause of end-stage kidney disease in the first three decades of life. A 27-year-old male was presented with gait imbalance, sever pruritus since 10 days prior time of admission. In past medical history, he had bilateral cataract, torsional nystagmus, and bilateral optic nerve atrophy since 2 years of age. Read More

    Myopathy in Pediatric Thyroid States: A Review of the Literature.
    Pediatr Endocrinol Rev 2016 Dec;14(2):147-158
    Department of Pediatrics, Division of Pediatric Endocrinology, New York University School of Medicine, New York, NY, USA.
    This review highlights the presentations of myopathy in children in both hypothyroid and hyperthyroid states with an emphasis on the pathophysiology, diagnosis and treatment. Based on our review of the literature data, myopathy should be considered in all children presenting with muscular weakness or altered muscle enzymes in the context of thyroid disease. Read More

    Fetal recurrent thyrotoxicosis.
    Ultrasound Obstet Gynecol 2017 May 15. Epub 2017 May 15.
    Maternal Fetal Medicine Unit. Department of Obstetrics. University Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
    Fetal hyperthyroidism is a rare and potentially life-threatening condition, not always easy to detect(1,2) . It is most commonly observed in maternal thyroid autoimmune disorders such as poorly controlled Grave's disease. Transplacental passage of maternal thyroid stimulating immunoglobulins (TSI) is the main cause of fetal thyroid gland stimulation and the clinical manifestations of this disorder: intrauterine growth restriction, non-immune hydrops, fetal goiter, tachycardia, craniosynostosis, accelerate bone maturation and intrauterine death(2) . Read More

    Issues in Managing Hurthle Cell Carcinoma of Thyroid: A Case Report.
    Cureus 2017 Apr 14;9(4):e1167. Epub 2017 Apr 14.
    Oncology, Kingston General Hospital and Hotel Dieu Hospital, Queens University.
    A 61-year-old woman noticed a right neck lump in October 2001. Fine needle aspiration showed follicular neoplasm, adenoma versus carcinoma. The ultrasound scan showed a solid mass of maximum dimension of 3. Read More

    Targeted next generation sequencing identifies somatic mutations and gene fusions in papillary thyroid carcinoma.
    Oncotarget 2017 Apr 25. Epub 2017 Apr 25.
    Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Head and Neck Surgery, Peking University Cancer Hospital & Institute, Beijing, China.
    138 papillary thyroid carcinoma (PTC) samples were assessed for somatic mutation profile and fusion genes by targeted resequencing using a cancer panel (ThyGenCapTM) targeting 244 cancer-related genes and 20 potential fusion genes. At least one genetic alteration (including mutations and fusion genes) was observed in 118/138 (85.5%) samples. Read More

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