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    [Ovarian teratomas as the cause of diseases of the nervous, endocrine and haematology system].
    Wiad Lek 2016 ;69(6):786-790
    I Klinika Ginekologii Onkologicznej i Ginekologii Uniwersytet Medyczny w Lublinie, Polska.
    Teratomas are the most common tumors of the ovary occurring in girls and young women. Derived from primordial germ cell and embryonic gonads have the ability to differentiate into the three germ layers. In about 95% of cases are benign, and their most common form is a dermoid cyst of the ovary. Read More

    Malignant tumors associated with ovarian mature teratoma: A single institution experience.
    Pathol Res Pract 2017 Jan 22. Epub 2017 Jan 22.
    Department of Gynecology and Obstetrics, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
    Objective: The aims of this study are to present demographical features of cases diagnosed with malignant tumor associated with ovarian mature teratoma and to analyze histopathological features and clinical follow up of these tumors.

    Study Design: Single-institution retrospective charts were reviewed to identify all cases of ovarian mature teratoma diagnosed from 1998 to 2015. Clinicopathological parameters that were analyzed include age, tumor size, tumor stage, histological type, laterality, IOC diagnosis and whether or not patient has received adjuvant chemotherapy. Read More

    The relationship between BRAFV600E, NF-κB and TgAb expression in papillary thyroid carcinoma.
    Pathol Res Pract 2017 Jan 12. Epub 2017 Jan 12.
    Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, PR China. Electronic address:
    Purpose: The aim of this study was to investigate the potential link between thyroglobulin antibody (TgAb) titers and papillary thyroid carcinoma (PTC) aggressiveness.

    Materials And Methods: This retrospective study included 122 patients who had undergone total thyroidectomy and neck central area lymph dissection followed by radioactive iodine (RAI) ablation for PTC between July 2012 and July 2014. The parameters included clinical characteristics of PTC, TgAb levels and tumor histopathological characteristics. Read More

    Primary multiple tumor with affection of the thyroid gland, uterus, urinary bladder, mammary gland and other organs.
    Pathol Res Pract 2017 Jan 19. Epub 2017 Jan 19.
    Sumy State University, Foreign Languages Department, Ukraine. Electronic address:
    Background: Nowadays multiple primary tumor is characterized by growth and development of two or more tumors in one patient. The total world sickness rate ranges from 1% to 37%. The presence of four or more tumors in one patient is rare case and presented as casuistry. Read More

    MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression.
    Nat Commun 2017 Feb 17;8:14448. Epub 2017 Feb 17.
    James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA.
    Exosomes are emerging mediators of intercellular communication; whether the release of exosomes has an effect on the exosome donor cells in addition to the recipient cells has not been investigated to any extent. Here, we examine different exosomal miRNA expression profiles in primary mouse colon tumour, liver metastasis of colon cancer and naive colon tissues. In more advanced disease, higher levels of tumour suppressor miRNAs are encapsulated in the exosomes. Read More

    Birth size, risk factors across life and cognition in late life: protocol of prospective longitudinal follow-up of the MYNAH (MYsore studies of Natal effects on Ageing and Health) cohort.
    BMJ Open 2017 Feb 16;7(2):e012552. Epub 2017 Feb 16.
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.
    Introduction: For late-life neurocognitive disorders, as for other late-life chronic diseases, much recent interest has focused on the possible relevance of Developmental Origins of Health and Disease (DOHaD). Programming by undernutrition in utero, followed by overnutrition in adult life may lead to an increased risk, possibly mediated through cardiovascular and metabolic pathways. This study will specifically examine, if lower birth weight is associated with poorer cognitive functioning in late life in a south Indian population. Read More

    Isolated Hypoplasia of Left Pulmonary Artery with Agenesis of Left Lobe of Thyroid: A Case Report.
    J Clin Diagn Res 2016 Dec 1;10(12):SD04-SD05. Epub 2016 Dec 1.
    Professor and Head, Department of Cardiology, Chettinad Hospital and Research Institute , Chennai, Tamil Nadu, India .
    Isolated Unilateral hypoplasia or agenesis of a branch of pulmonary artery is very rare. It is usually seen associated with congenital heart diseases such as tetralogy of Fallot, atrial septal defect, coarctation of the aorta, right aortic arch, truncus arteriosus, patent ductus arteriosus and pulmonary atresia. It occurs as a result of lack of embryological development of either the left or right sixth aortic arch and has been found to present itself with various clinical manifestations as during childhood it presents as contralateral pulmonary hypertension and in adults as haemoptysis. Read More

    A rare case report of very low thyroglobulin and a negative whole-body scan in a patient with a solid variant of papillary thyroid carcinoma with distant metastases.
    Medicine (Baltimore) 2017 Feb;96(7):e6086
    Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, PR China.
    Rationale: The early detection of recurrent differentiated thyroid carcinoma (DTC) cells in postsurgery DTC patients relies on the sensitivity of measuring both the level of thyroglobulin (Tg) and 131-iodine distribution on a whole-body scan (WBS). Recent studies have defined patients who subsequently have no evidence of disease as those who have a stimulated Tg level <1 ng/mL with no other radiological or clinical evidence of disease.

    Patient Concerns: A woman patient with solid variant papillary thyroid carcinoma (SVPTC) had undergone twice thyroidectomy with lymph node dissection and radioactive therapy. Read More

    Two Rare Variants of Left Vertebral Artery.
    J Craniofac Surg 2017 Feb 15. Epub 2017 Feb 15.
    Department of Anatomy, AIIMS Rishikesh, Rishikesh, India.
    Though the variations of vertebral artery are clinically asymptomatic yet abnormalities are of diagnostic importance either prior to vascular surgery in the neck region or in patients of intravascular diseases such as arteriovenous malformations or cerebral aneurysms. Therefore, the aim of the study is to bring out 2 variations in the configuration of vertebral artery and their clinical implication. During dissection of thorax of 2 female cadavers, 2 different variants of configurations of left vertebral arteries were observed. Read More

    A 'silent' skull metastatic follicular thyroid carcinoma mimicking as a benign scalp tumor in a pregnant woman.
    Endocrinol Diabetes Metab Case Rep 2017 12;2017. Epub 2017 Jan 12.
    Departments of Plastic and Reconstructive Surgery.
    : Thyroid cancer with cranial metastasis in a pregnant woman is very rare. In the literature, most cases are diagnosed early from neurogenic signs or symptomatic thyroid gland. Pregnancy also contributes to a hesitation toward early surgical and medical treatments. Read More

    Histologic Findings and Cytological Alterations in Thyroid Nodules After Radioactive Iodine Treatment for Graves' Disease.
    Int J Surg Pathol 2017 Feb 1:1066896917693091. Epub 2017 Feb 1.
    1 Mount Sinai Medical Center, Miami Beach, FL, USA.
    Unlike the well-documented relation between radiation to the neck and development of papillary thyroid carcinoma, a causal association between radioactive iodine treatment for Graves' disease and development of thyroid malignancy is less defined. However, patients with a background of thyroid dysfunction presenting with clinically palpable thyroid nodules are followed more closely than the average population, and fine needle aspiration is recommended in such circumstances. Cytological examination of aspirates, and histologic examination of tissue provided from patients with a known history of Graves' disease, managed by radioactive iodine therapy can create a diagnostic dilemma, as the distinction between radiation effect and a malignant primary thyroid neoplasm can be very challenging. Read More

    Thyroid gland in chronic obstructive pulmonary disease.
    Adv Respir Med 2017 ;85(1):28-34
    The risk of chronic obstructive pulmonary disease (COPD), as well as thyroid diseases increases with age. COPD is a common systemic disease associated with chronic inflammation. Many endocrinological disorders, including thyroid gland diseases are related to systemic inflammation. Read More

    Gender differences in clinical and polysomnographic features of obstructive sleep apnea: a clinical study of 2827 patients.
    Sleep Breath 2017 Feb 14. Epub 2017 Feb 14.
    Department of Chest Diseases, Ege University School of Medicine, Bornova, 35100, Izmir, Turkey.
    Purpose: Obstructive sleep apnea (OSA) is underdiagnosed in females due to different clinical presentation. We aimed to determine the effect of gender on clinical and polysomnographic features and identify predictors of OSA in women.

    Methods: Differences in demographic, clinical, and polysomnographic parameters between 2052 male and 775 female OSA patients were compared. Read More

    Metformin and thyroid disease.
    J Endocrinol 2017 Feb 14. Epub 2017 Feb 14.
    C Liu, Endocrinology, Jiangsu Province Hospital of Integration on Chinese and Western Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing, China
    An intriguing area of research in thyroidology is the recently discovered association of insulin resistance with thyroid functional and morphological abnormalities. Individuals with hyperinsulinemia have larger thyroid gland and a higher prevalence of thyroid nodules and cancer. Accordingly, patients treated with metformin have a smaller thyroid volume and a lower risk of incident goiter, thyroid nodule and cancer. Read More

    Intraindividual variation of microRNA expression levels in plasma and peripheral blood mononuclear cells and the associations of these levels with the pathogenesis of autoimmune thyroid diseases.
    Clin Chem Lab Med 2017 Feb 14. Epub 2017 Feb 14.
    Background: MicroRNAs (miRNAs) circulate in the blood and negatively regulate the expression of mRNAs. Some miRNAs are associated with the development of autoimmune thyroid diseases (AITD); however, there are few reports on the association between miRNA expression and the pathogenesis of AITD or the physiological variations of circulating miRNAs, which are important to examine as biomarkers.

    Methods: We examined the circadian and day-to-day variations in the expression levels of 5 miRNAs (miR-125a, miR-146a, miR-155, let-7e and miR-106a) in plasma and peripheral blood mononuclear cells (PBMC). Read More

    Phrenic nerve stimulation during neck dissection for advanced thyroid cancer involving level IV: is it worth doing it?
    Updates Surg 2017 Feb 13. Epub 2017 Feb 13.
    Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    During thyroidectomy and neck dissection surgery for advanced or recurrent metastatic thyroid cancer under intraoperative monitoring, we used the available technology to assess the feasibility of such an intervention to monitor those patients with phrenic nerves at risk. A retrospective review of patients operated on from January 2009 to December 2015 by a single surgeon (CSD) was conducted. Patients who had neck and mediastinal dissection, with or without total thyroidectomy, due to advanced or recurrent metastatic disease to the neck were selected. Read More

    Primary Thyroid Lymphoma: Clinicopathologic Characteristics and Therapeutic Outcomes of Six Cases in Morocco.
    • Authors:
    Gulf J Oncolog 2016 Sep;1(22):11-15
    Background: Primary non-Hodgkin lymphomas of the thyroid are uncommon and account for 1-5% of all thyroid malignancies and less than 2% of extranodal lymphomas. The aim of the present study was to review our experience and management of primary thyroid lymphoma and to discuss the diagnostic and therapeutic considerations.

    Methods: All non-Hodgkin lymphoma diagnosed at our institution between 2007 and 2011 were reviewed, six cases of primary thyroid lymphoma were identified. Read More

    Extrahepatic Autoimmune Diseases in Patients with Autoimmune Liver Diseases: A Phenomenon Neglected by Gastroenterologists.
    Gastroenterol Res Pract 2017 16;2017:2376231. Epub 2017 Jan 16.
    Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin 300052, China.
    Autoimmune liver diseases (AILDs) often coexist with other extrahepatic autoimmune diseases (EHAIDs). The spectrum of EHAIDs in patients with AILDs is similar, whereas the incidence is different. Notably, autoimmune thyroid disease and Sjogren's syndrome are the most common EHAIDs. Read More

    A novel integrative risk index of papillary thyroid cancer progression combining genomic alterations and clinical factors.
    Oncotarget 2017 Feb 6. Epub 2017 Feb 6.
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
    Although the majority of papillary thyroid cancer (PTC) is indolent, a subset of PTC behaves aggressively despite the best available treatment. A major clinical challenge is to reliably distinguish early on between those patients who need aggressive treatment from those who do not. Using a large cohort of PTC samples obtained from The Cancer Genome Atlas (TCGA), we analyzed the association between disease progression and multiple forms of genomic data, such as transcriptome, somatic mutations, and somatic copy number alterations, and found that genes related to FOXM1 signaling pathway were significantly associated with PTC progression. Read More

    A comparative study of nuclear 8-hydroxyguanosine expression in Autoimmune Thyroid Diseases and Papillary Thyroid Carcinoma and its relationship with p53, Bcl-2 and Ki-67 cancer related proteins.
    Adv Med Sci 2016 Jun 22;62(1):45-51. Epub 2016 Jun 22.
    Laboratory of Analysis, Development and Food Safety, Research Group "Biotechnology and Pathology", National School of Engineers of Sfax, Sfax, Tunisia.
    Purpose: To investigate whether the oxidative stress is involved in the evolution of Graves' disease (GD) and Hashimoto thyroiditis (HT) into Papillary Thyroid Carcinoma (PTC), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and cancer related proteins (Bcl-2, p53 and Ki-67) expressions were evaluated in these pathologies.

    Patients And Methods: Immunohistochemical method was applied on 25 thyroid tissues. Allred score (AS) serving to evaluate the immunostaining is based on a scale from 0 to 8. Read More

    Frontal bone metastasis from an occult follicular thyroid carcinoma: Diagnosed by FNAC.
    J Cytol 2017 Jan-Mar;34(1):59-61
    Department of Pathology, PGIMS, Rohtak, India.
    Metastatic deposits in skull bones from follicular thyroid carcinoma is rare, and metastatic disease in skull being the presenting symptom without obvious thyroid lesion (occult primary) is even rarer. A 60-year-old female patient presented with a mass in the frontal region of the skull. Fine needle aspiration cytology was done which revealed an adenocarcinoma with repeated follicular pattern, reminiscent of follicular neoplasm of thyroid, which on immunocytochemistry revealed positivity for thyroglobulin. Read More

    Thyroid dysfunction and nonalcoholic fatty liver disease.
    Minerva Endocrinol 2017 Feb 9. Epub 2017 Feb 9.
    Department of Endocrinology, "Hippokration" General Hospital of Thessaloniki, Thessaloniki, Greece.
    Thyroid hormones are crucial for hepatic lipid and glucose metabolism. Nonalcoholic fatty liver disease (NAFLD), a very common and potentially serious disease of modern society, shares common clinical features with hypothyroidism, such as obesity, insulin resistance and dyslipidemia. Furthermore, in certain studies, increased prevalence of hypothyroidism was observed in patients with NAFLD. Read More

    Thyrotropin receptor gene expression in the association between chronic spontaneous urticaria and Hashimoto's thyroiditis.
    Int J Dermatol 2017 Feb 8. Epub 2017 Feb 8.
    Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University - Unesp, Botucatu, Sao Paulo, Brazil.
    Background: Chronic spontaneous urticaria (CSU) may be associated with autoimmune thyroid diseases, and the Autologous Serum Skin Test (ASST) is an autoreactivity marker. The thyrotropin (TSH) and TSH receptor (TSHR) could play a role in the pathogenesis of CSU. The aim of this study was to evaluate ASST positivity and TSHR gene expression in healthy skin and ASST wheals in euthyroid women with CSU, with (14 patients) and without (15 patients) Hashimoto's thyroiditis (HT). Read More

    Changing trend in referral to secondary care specialist thyroid eye disease clinic following the Amsterdam declaration.
    Int Ophthalmol 2017 Feb 8. Epub 2017 Feb 8.
    Department of Endocrinology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, UK.
    Introduction: Early diagnosis and treatment of thyroid eye disease (TED) improves outcomes. Previous studies have highlighted delays in diagnosis and referral to specialist centres. The Amsterdam declaration (2009) aimed to halve the time from presentation to diagnosis and from diagnosis to referral to a specialist centre in five years. Read More

    Thyroid Ultrasound: State of the Art Part 1 - Thyroid Ultrasound reporting and Diffuse Thyroid Diseases.
    Med Ultrason 2017 Jan;19(1):79-93
    Department of Internal Medicine 2, Caritas Hospital, Bad Mergentheim, Germany, Sino-German Research Center of Ultrasound in Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
    Accurate differentiation of focal thyroid nodules (FTL) and thyroid abnormalities is pivotal for proper diagnostic and therapeutic work-up. In these two part articles, the role of ultrasound techniques in the characterization of FTL and evaluation of diffuse thyroid diseases is described to expand on the recently published World Federation in Ultrasound and Medicine (WFUMB) thyroid elastography guidelines and review how this guideline fits into a complete thyroid ultrasound exam. Read More

    Rituximab Can Induce Remission in a Patient with Ankylosing Spondylitis Who Failed Anti-TNF-α Agent.
    Am J Case Rep 2017 Feb 9;18:143-147. Epub 2017 Feb 9.
    Department of Internal Medicine, Dr. Soliman Fakeeh Hospital, Jeddah, Saudi Arabia.
    BACKGROUND Ankylosing spondylitis (AS) is a chronic inflammatory disease that predominantly affects the axial skeleton. The ability of anti-TNF-α agents to reduce disease activity in patients with axial spondyloarthritis (axSpA), including AS, has been demonstrated in multiple randomized trials and several meta-analyses. Reports on the efficacy of rituximab in treatment of AS have described good results. Read More

    Risk factors for post-thyroidectomy hemorrhage: a meta- analysis.
    Eur J Endocrinol 2017 Feb 8. Epub 2017 Feb 8.
    H Zhang, Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, China
    Background Post-thyroidectomy haemorrhage is a rare but potentially life-threatening and unpredictable complication of thyroid surgery. In this study, we analysed the potential risk factors for the occurrence of post-thyroidectomy haemorrhage. Methods The PubMed and SCIE databases were comprehensively searched for studies published before June 30, 2016. Read More

    Overwhelming rapid metabolic and structural response to apatinib in radioiodine refractory differentiated thyroid cancer.
    Oncotarget 2017 Feb 2. Epub 2017 Feb 2.
    Department of Oncology, Peking University International Hospital, Beijing 102206, China.
    Currently, patients with radioiodine refractory differentiated thyroid cancer (RAIR-DTC) have limited treatment options. In this study, we aimed to assess the short-term efficacy and safety of apatinib in RAIR-DTC. Ten adult patients were prospectively enrolled to receive oral apatinib (750 mg q. Read More

    P21-activated kinase 4 involves TSH induced papillary thyroid cancer cell proliferation.
    Oncotarget 2017 Feb 4. Epub 2017 Feb 4.
    Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, P.R. China.
    Papillary thyroid cancer is a common endocrine malignancy. Although p21-activated kinase 4 (PAK4) is involved in the development of different types of tumor, its function has not been investigated in papillary thyroid cancer. Here, we identified a role for PAK4 in papillary thyroid cancer progression. Read More

    Family history of cancer other than breast or ovarian cancer in first-degree relatives is associated with poor breast cancer prognosis.
    Breast 2017 Feb 5;32:130-134. Epub 2017 Feb 5.
    Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, PR China. Electronic address:
    Objective: Whether a first-degree family history of others cancers (FHOC) than breast or ovarian cancer (BOC) is associated with breast cancer prognosis remains unknown. Thus, the aim of the present study was to clarify this issue.

    Methods: Women who were diagnosed with invasive breast cancer at the Renmin Hospital of Wuhan University from 2010 to 2013 were included in the study. Read More

    A new method of subtotal thyroidectomy for Graves' disease leaving a unilateral remnant based on the upper pole.
    Medicine (Baltimore) 2017 Feb;96(6):e5919
    aDepartment of Thyroid and Breast Surgery bInstitute of Orthopedics, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
    Background: The aim of this prospective randomized study was to evaluate the feasibility of subtotal thyroidectomy with leaving a unilateral remnant based on the upper pole.

    Methods: Patients who underwent the subtotal thyroidectomy and isthmusectomy leaving either a unilateral remnant based on the upper pole (Group I, 79 patients) or the bilateral dorsal thyroid tissue remained (Group II, 89 patients) were compared in operation time, blood loss, recurrence, and postoperative complications.

    Results: Among 168 patients analyzed, the operation time remained similar, but the blood loss, the reoperation time, and recurrence in Group I were much less than Group II. Read More

    Anaplastic thyroid carcinoma and foscarnet use in a multitarget treatment documented by 18F-FDG PET/CT: A case report.
    Medicine (Baltimore) 2017 Feb;96(6):e5621
    aDepartment of Experimental Medicine bDepartment of Internal Medicine and Clinical Specialities cDepartment of Radiology, Anatomopathology and Oncology, Sapienza University of Rome, Rome dNuclear Medicine Unit, Department of Interventional Oncology, Azienda Ospedaliera Ospedale di Circolo di Busto Arsizio Varese, Busto Arsizio, Varese, Italy.
    Rationale: The case reported the rapid remission of disease recurrence achieved adding foscarnet, a DNA polymerase inhibitor that interacts with fibroblast growth factor 2, to low molecular weight heparin and sunitinib for the first time in a patient with an anaplastic thyroid cancer (ATC).

    Patient Concerns: A 65-year-old woman with a multinodular goiter referred for a rapid enlargement of a nodule. Histological examination revealed an ATC with a little area of papillary thyroid cancer (PTC). Read More

    Hypothyroidism and nephrotic syndrome: why, when and how to treat.
    Curr Vasc Pharmacol 2017 Feb 7. Epub 2017 Feb 7.
    Department of Clinical Medicine, Sapienza University of Rome, Rome,. Italy.
    Hypothyroidism, characterised by low/normal free thyroxine (FT4) and free tri-iodothyronine (FT3) with elevated thyroid-stimulating hormone (TSH), is a well-known complication of nephrotic syndrome (NS). This is a common feature of primary and secondary glomerular diseases and comprises loss of protein in the urine and increased urinary excretion of thyroid hormones and thyroxine-binding globulin. With a normal thyroid reserve, this scenario is associated with the development of subclinical hypothyroidism, with a slight increase in TSH and normal free fractions. Read More

    Congenital Hypothyroidism: Facts, Facets & Therapy.
    Curr Pharm Des 2017 Feb 6. Epub 2017 Feb 6.
    Department of Biotechnology, Vignan's Foundation for Science, Technology and Research University (VFSTRU), Guntur 522213, Andhra Pradesh,. India.
    Back ground: Thyroid hormone (T3) is essential for normal development of children enabling brain development and somatic growth. However, certain individuals are genetically predisposed with insufficient or no thyroid hormones. Such a condition is termed congenital hypothyroidism (CH). Read More

    Comparison of hepatectomy with or without hepatic inflow occlusion in patients with hepatocellular carcinoma: a single-center experience.
    Minerva Med 2017 Feb 7. Epub 2017 Feb 7.
    Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.
    Background: The negative effects of hepatic inflow occlusion (HIO) on postoperative liver function of patients with hepatocellular carcinoma (HCC) after liver resection have been reported. Nevertheless, whether HIO could influence the long-term outcomes remains unclear.

    Methods: A total of 396 patients were included in this study and divided into without occlusion (WO) group (n=112) and HIO group (n=284). Read More

    Fibromyalgia in patients with thyroid autoimmunity: prevalence and relationship with disease activity.
    Clin Rheumatol 2017 Feb 7. Epub 2017 Feb 7.
    Department of Physical Medicine and Rehabilitation, Erzurum Regional Research and Training Hospital, Erzurum, Turkey.
    Fibromyalgia (FM) is a syndrome characterised by chronic musculoskeletal pain, tenderness and other somatic symptoms. The prevalence of FM is approximately 2-7% in the general global population and is 30-40% in the population of Hashimoto thyroiditis (HT) with a structural pathology. In 2010, new classification criteria for FM were proposed, as an alternative to the American College of Rheumatology (ACR) 1990 criteria. Read More

    [Characteristics of Adolescent and Young Adult Cancer].
    Gan To Kagaku Ryoho 2017 Jan;44(1):7-11
    Clinical Research Center, National Hospital Organization Nagoya Medical Center.
    In adolescent and young adult(AYA)population, cancer is the leading cause of death due to illness with the lowest mortality rate as well as children, and national measures for cancer was left behind. Leukemia, lymphomas, brain tumors, thyroid cancer, ovarian cancer, cervical cancer, breast cancer, testicular cancer and bone and soft tissue sarcomas account for majority of the cancers in this age group. There has been no significant improvement in AYA patients in contrast to other age groups. Read More

    New insights into thyroid hormone action.
    Pharmacol Ther 2017 Feb 4. Epub 2017 Feb 4.
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. Electronic address:
    Thyroid hormones (TH) are endocrine messengers essential for normal development and function of virtually every vertebrate. The hypothalamic-pituitary-thyroid axis is exquisitely modulated to maintain nearly constant TH (T4 and T3) levels in circulation. However peripheral tissues and the CNS control the intracellular availability of TH, suggesting that circulating concentrations of TH are not fully representative of what each cell type sees. Read More

    Diagnosis and Treatment of Pituitary Adenomas: A Review.
    JAMA 2017 Feb;317(5):516-524
    Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
    Importance: Pituitary adenomas may hypersecrete hormones or cause mass effects. Therefore, early diagnosis and treatment are important.

    Observations: Prevalence of pituitary adenomas ranges from 1 in 865 adults to 1 in 2688 adults. Read More

    [Isoflavone-containing dietary supplements].
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2017 Feb 6. Epub 2017 Feb 6.
    Institut für Sicherheit und Qualität bei Obst und Gemüse, Max Rubner-Institut, Karlsruhe, Deutschland.
    Isoflavones (IFs) from soy and other legumes have weak estrogenic properties. Isolated IFs are available as dietary supplements and advertised to alleviate symptoms of menopause. The present chapter provides an overview of the occurrence, the chemical structure of IFs and their metabolites, the market situation and reviews the current evidence on the efficacy and safety of IF-containing dietary supplements. Read More

    Intraoperative Identification of the Parathyroid Gland with a Fluorescence Detection System.
    World J Surg 2017 Feb 6. Epub 2017 Feb 6.
    Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
    Background: Intraoperative identification of the difficult-to-spot parathyroid gland is critical during surgery for thyroid and parathyroid disease. Recently, intrinsic fluorescence of the parathyroid gland was identified, and a new method was developed for intraoperative detection of the parathyroid with an original fluorescent detection apparatus. Here, we describe a method for intraoperative detection of the parathyroid using a ready-made photodynamic eye (PDE) system without any fluorescent dye or contrast agents. Read More

    Autoimmune/Inflammatory Syndrome Induced by Adjuvants and Thyroid Autoimmunity.
    Front Endocrinol (Lausanne) 2016 24;7:150. Epub 2017 Jan 24.
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Aviv, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Tel-Aviv University, Tel-Aviv, Israel.
    The autoimmune/inflammatory syndrome induced by adjuvants (ASIA), presented by Shoenfeld and Agmon-Levin in 2011, is an entity that incorporates diverse autoimmune conditions induced by the exposure to various adjuvants. Adjuvants are agents that entail the capability to induce immune reactions. Adjuvants are found in many vaccines and used mainly to increase the response to vaccination in the general population. Read More

    High frequency ultrasound features and pathological characteristics of medullary thyroid carcinoma.
    Pak J Pharm Sci 2016 Nov;29(6(Suppl)):2269-2271
    Pathology Department of the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
    To study high-frequency ultrasound features and pathological characteristics of medullary thyroid carcinoma (medullary thyroid carcinoma, MTC) with the purpose to improve the diagnostic accuracy of this disease. The clinical data of 20 cases of patients with MTC confirmed by the clinical surgery were retrospectively analyzed. And the high-frequency ultrasound features were analyzed and compared with the pathological characteristics. Read More

    Antidepressant and anxiolytic-like activity of sodium selenite after acute treatment in mice.
    Pharmacol Rep 2016 Nov 11;69(2):276-280. Epub 2016 Nov 11.
    Department of Pharmacology and Pharmacodynamics, Faculty of Pharmacy with Division of Medical Analytics, Medical University of Lublin, Lublin, Poland.
    Background: Selenium (Se) is an essential trace element for humans and animals, that is needed for a broad variety of physiological functions including thyroid hormone metabolism, protection against oxidative stress, and immunity associated functions. Human nutritional Se deficiencies are associated with neuropsychiatric diseases, like Alzheimer's disease, Parkinson's disease, obsessive - compulsive disorder, stroke, epilepsy as well as depressive behaviours. In this study we examined antidepressant- and anxiolytic-like activity of Se in the inorganic form of sodium selenite and investigated whether Se influence on the locomotor activity in mice. Read More

    Parathyroid reimplantation with PR-FaST technique in unselected patients during thyroidectomy. A case series with long term follow up confirming graft vitality and parathormone production.
    Int J Surg 2017 Feb 3;39:202-205. Epub 2017 Feb 3.
    Department of Surgery "P. Valdoni", Sapienza University, Rome, Italy.
    Introduction: Parathyroid damage or unintentional excision still affect thyroid surgery and may cause permanent hypoparathyroidism. The only way to recover the excised or ischemic gland functionality is still reimplantation. Many sites of reimplantation have been described, each of one showing both advantages and drawbacks. Read More

    The Blood Bank for Diabetes Screening: a Feasible Alternative?
    Clin Lab 2017 Jan;63(1):21-26
    Background: Vascular complications of diabetes mellitus (DM) are associated with 5% of deaths globally every year. Early diagnosis and treatment could reduce this figure. The aim of this project was to investigate the frequency of undiagnosed DM among blood donors and the possibility of blood banks participating in DM screening. Read More

    The IL15 +96522 A>T functional polymorphism is related to the differentiation of Th17 cells and the severity of Hashimoto's disease.
    Int J Immunogenet 2017 Feb 5. Epub 2017 Feb 5.
    Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
    To clarify the association between the genetic producibility of IL-15, a pro-inflammatory cytokine, and the pathogenesis of autoimmune thyroid diseases (AITDs), we genotyped +96522 A>T and +82889 A>G polymorphisms in the IL15 gene using 127 patients with Hashimoto's disease (HD), including 55 patients with severe HD and 48 patients with mild HD; 130 patients with Graves' disease (GD), including 52 patients with intractable GD and 44 patients with GD in remission; and 79 healthy volunteers. Both the IL15 +96522 A allele and AA genotype were more frequent in patients with severe HD than in those with mild HD. The serum levels of IL-15 were higher in individuals with the IL15 +96522 AA genotype than in those with the T allele, and they were also higher in patients with severe HD than in those with mild HD. Read More

    Perinatal factors associated with neonatal thyroid-stimulating hormone in normal newborns.
    Ann Pediatr Endocrinol Metab 2016 Dec 31;21(4):206-211. Epub 2016 Dec 31.
    Department of Pediatrics, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.
    Purpose: This study was to evaluate the effect of neonatal, maternal, and delivery factors on neonatal thyroid-stimulating hormone (TSH) of healthy newborns.

    Methods: Medical records of 705 healthy infants born through normal vaginal delivery were reviewed. Neonatal TSH levels obtained by neonatal screening tests were analyzed in relation to perinatal factors and any associations with free thyroxine (FT4) and 17-α hydroxyprogesterone (17OHP) levels. Read More

    Isolated Liver Metastasis in Hürthle Cell Thyroid Cancer Treated with Microwave Ablation.
    Case Rep Endocrinol 2017 9;2017:2790741. Epub 2017 Jan 9.
    Endocrinology, Diabetes and Metabolism, The Ohio State University Wexner Medical Center, 5th Floor McCampbell Hall, 1581 Dodd Drive, Columbus, OH 43210, USA.
    Hürthle cell thyroid cancer (HCTC) is a less common form of differentiated thyroid cancer. It rarely metastasizes to the liver, and when it does, the metastasis is almost never isolated. Here we report a 62-year-old male with widely invasive Hürthle cell thyroid cancer, who underwent total thyroidectomy and received adjuvant treatment with I-131 with posttreatment scan showing no evidence of metastatic disease. Read More

    Effects of Vitamin D treatment on thyroid autoimmunity.
    J Res Med Sci 2016 18;21:85. Epub 2016 Oct 18.
    Department of Endocrinology and Metabolism, Kayseri Training and Research Hospital, Kayseri, Turkey.
    Background: Vitamin D was shown to be related to autoimmune thyroid diseases (AITDs) in the previous studies. We aimed to investigate the relationship between Vitamin D and thyroid autoimmunity.

    Materials And Methods: Eighty-two patients, diagnosed with AITD by the endocrinology outpatient clinic, were included in this prospective study. Read More

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