186,923 results match your criteria Thyroid Disease

The ethanolic extract of Artemisia anomala exerts anti-inflammatory effects via inhibition of NLRP3 inflammasome.

Phytomedicine 2022 May 10;102:154163. Epub 2022 May 10.

Laboratory of Natural Product Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Medical School, West China Hospital, Sichuan University, Chengdu 610041, PR China.

Background: Artemisia anomala S. Moore (Compositae), known as "Nan-Liu-Ji-Nu" in traditional Chinese medicine (TCM), has been used to treat many inflammatory diseases, including enteritis, acute icteric hepatitis, rheumatism, toothache, tonsillitis, and chronic bronchitis, for centuries. Our preliminary studies have demonstrated that the ethanolic extract of A. Read More

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Radix Ranunculi ternati: review of its chemical constituents, pharmacology, quality control and clinical applications.

J Pharm Pharmacol 2022 May 21. Epub 2022 May 21.

School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.

Objectives: Radix ranunculi ternati (RRT) is widely used as traditional and folk medicine distributed in China, as well as in Kyushu and Shikoku in Japan. Although RRT has a short history of use as medicine, it has a high medicinal value. This study summarizes the research progress on the chemical constituents, pharmacological activity, quality control measures and clinical applications to provide a valuable and exhaustive reference for the development and application of RRT. Read More

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Association of thyroid peroxidase antibodies and thyroglobulin antibodies with thyroid function in pregnancy - an individual participant data meta-analysis.

Thyroid 2022 May 20. Epub 2022 May 20.

University of Southern California Keck School of Medicine, 12223, Department of Preventive Medicine, Los Angeles, California, United States;

Objectives: Thyroid autoimmunity is common in pregnant women and associated with thyroid dysfunction and adverse obstetric outcomes. Most studies focus on thyroid peroxidase autoantibodies (TPOAbs) assessed by negative-positive dichotomy and rarely take into account thyroglobulin autoantibodies (TgAbs). This study aimed at determining the association of TPOAbs and TgAbs, respectively and interdependently, with maternal thyroid function. Read More

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Transient Hypocalcemia After Total Thyroidectomy: The Obesity Paradox at Work?

J Surg Res 2022 May 17;278:93-99. Epub 2022 May 17.

Division of Endocrine Surgery; DeWitt Daughtry Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida.

Introduction: With increasing rates of obesity worldwide, a correlation between high body mass index (BMI) and postoperative morbidity after thyroid surgery remains unclear. Postoperative transient hypocalcemia is common after total thyroidectomy due to interruption of parathyroid function. This study examines the relationship between BMI and hypocalcemia after total thyroidectomy. Read More

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Differential gene expression profile of multinodular goiter.

PLoS One 2022 20;17(5):e0268354. Epub 2022 May 20.

School of Health Sciences, State University of Amazonas, Manaus, Amazonas, Brazil.

Introduction: The goiter, a neglected heterogeneous molecular disease, remains a major indication for thyroidectomies in its endemic regions.

Objectives: This study analyzed differential gene expression in surgical specimens diagnosed with multi nodular and compared the data to that of thyroid tissue without multinodular goiter from patients undergoing thyroidectomy in Manaus-AM, Brazil using RNA-seq technology.

Methodology: The transcriptome information of the surgical specimen fragments with and without multinodular goiter was accessed by Illumina HiSeq 2000 New Generation Sequencing (NGS) using the RNA-seq NEBNext® Ultra™ RNA Library Prep Kit for Illumina®-#E7530L protocol and differential gene expression analysis. Read More

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Enhancing Radioiodine Incorporation Into Radio Iodine Refractory Thyroid Cancer With MAPK Inhibition (ERRITI): A Single-Center Prospective Two-Arm Study.

Clin Cancer Res 2022 May 20. Epub 2022 May 20.

University Hospital Essen, West German Cancer Center, Essen, Germany.

Purpose: Restoration of iodine incorporation (redifferentiation) by mitogen-activated protein kinase (MAPK) inhibition was achieved in previously radioiodine-refractory, unresectable thyroid carcinoma (RR-TC). However, results were unsatisfactory in BRAFV600E-mutant RR-TC. Here we assess safety and efficacy of redifferentiation therapy through genotype-guided MAPK-modulation in patients with BRAFV600E-mutant (BRAF-MUT) or wildtype (BRAF-WT) RR-TC. Read More

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Diagnosis and treatment of thyroid cancer in adult patients - Recommendations of Polish Scientific Societies and the National Oncological Strategy. 2022 Update [Diagnostyka i leczenie raka tarczycy u chorych dorosłych - Rekomendacje Polskich Towarzystw Naukowych oraz Narodowej Strategii Onkologicznej. Aktualizacja na rok 2022].

Endokrynol Pol 2022 ;73(2):173-300

Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland.

The guidelines Thyroid Cancer 2022 are prepared based on previous Polish recommendations updated in 2018. They consider international guidelines - American Thyroid Association (ATA) 2015 and National Comprehensive Cancer Network (NCCN); however, they are adapted according to the ADAPTE process. The strength of the recommendations and the quality of the scientific evidence are assessed according to the GRADE system and the ATA 2015 and NCCN recommendations. Read More

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January 2022

Immune Checkpoint Inhibitor-Induced Thyroid Disorders: a Single Center Experience.

Curr Pharm Des 2022 May 18. Epub 2022 May 18.

Department of Clinical and Experimental Medicine, University of Pisa, Italy.

Background: Immune checkpoint inhibitors (ICI) foster T lymphocytes to fight cancer, but they can also trigger immune-related adverse events (irAE) in various organs, including thyroid dysfunction that can manifest itself in terms of both hyperthyroidism and hypothyroidism or subclinical disease.

Objective: Based on previous observations, this study evaluated the impact of oncological immunotherapy on the development of thyroid dysfunction in a cohort of patients treated with ICI at our institution.

Methods: We collected 10 cases of thyroid irAE that emerged from 24 cancer patients treated with immunotherapy, belonging to a cohort of 120 patients sent to our clinic by the Oncology Department of our institution, between December 2016 and March 2020. Read More

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The Association Between Serum Palmitic Acid and Thyroid Function.

Front Endocrinol (Lausanne) 2022 3;13:860634. Epub 2022 May 3.

Department of General Surgery, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Aim: Emerging evidence indicates that palmitic acid (PA) can regulate the progression and development of many diseases. However, the studies examining the association between PA and thyroid function remain sparse. We aimed to investigate the association between serum PA (sPA) and thyroid function in the US population. Read More

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Potential of Endogenous Oxytocin in Endocrine Treatment and Prevention of COVID-19.

Front Endocrinol (Lausanne) 2022 3;13:799521. Epub 2022 May 3.

Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.

Coronavirus disease 2019 or COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a significant threat to the health of human beings. While wearing mask, maintaining social distance and performing self-quarantine can reduce virus spreading passively, vaccination actively enhances immune defense against COVID-19. However, mutations of SARS-CoV-2 and presence of asymptomatic carriers frustrate the effort of completely conquering COVID-19. Read More

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How long-term metal and lead exposure among foundry workers affect COVID-19 infection outcomes in Jordan.

Mohamed Saadh

Environ Sci Pollut Res Int 2022 May 19. Epub 2022 May 19.

Faculty of Pharmacy, Middle East University, Amman, Jordan.

Foundry workers face a number of occupational health hazards, which may lead to an increased risk of respiratory disease, cancer, and anxiety level and are associated with endocrine, hematologic, renal, and neurological problems in humans. This study aims to evaluated thyroid functions, glutathione level, and the risk of infection with SARS-CoV-2 after vaccinated (two doses of the BNT162b2 mRNA COVID-19 vaccine) foundry workers in Jordan. We examined the efficacy BNT162b2 vaccine by calculating the rate of mortality and the degree of severity from mild to severe respiratory infections in 105 adult males foundry workers occupationally exposed to metals and Pb who had been received two doses, 21 days apart, of the BNT162b2 vaccine. Read More

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Nat Rev Dis Primers 2022 May 19;8(1):30. Epub 2022 May 19.

Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.

Hypothyroidism is the common clinical condition of thyroid hormone deficiency and, if left untreated, can lead to serious adverse health effects on multiple organ systems, with the cardiovascular system as the most robustly studied target. Overt primary hypothyroidism is defined as elevated thyroid-stimulating hormone (TSH) concentration in combination with free thyroxine (fT) concentration below the reference range. Subclinical hypothyroidism, commonly considered an early sign of thyroid failure, is defined by elevated TSH concentrations but fT concentrations within the reference range. Read More

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Cancer Risk in Patients With Fuchs Endothelial Corneal Dystrophy.

Cornea 2021 Sep 27. Epub 2021 Sep 27.

Department of Ophthalmology, Mayo Clinic, Rochester, MN.

Purpose: The purpose of this study is to quantify cancer risk in patients with Fuchs endothelial corneal dystrophy (FECD).

Methods: Using the 2014 to 2016 Medicare Limited 5% Data Sets-Carrier Line File, US Medicare fee-for-service beneficiaries (aged 65 years or older) with FECD and cancer were identified through International Classification of Diseases, ninth and 10th Revision diagnostic codes from January 1, 2014, to December 31, 2016. The main outcome measures were odds ratios (ORs) of cancer at various anatomic locations in patients with versus without FECD. Read More

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September 2021

Nationwide Incidence of Thyroid Eye Disease and Cumulative Incidence of Strabismus and Surgical Interventions in Denmark.

JAMA Ophthalmol 2022 May 19. Epub 2022 May 19.

Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Importance: Thyroid eye disease (TED) is a serious condition that can cause proptosis and strabismus and, in rare cases, lead to blindness. Incidence data for TED and strabismus and surgical interventions after TED are sparce.

Objective: To investigate the nationwide incidence of TED, strabismus, and surgical interventions associated with TED. Read More

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Associations Between Chronic Rhinosinusitis and Cancers: A Nationwide Population-Based Cohort Study.

Laryngoscope 2022 May 19. Epub 2022 May 19.

Departments of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Anyang, Republic of Korea.

Objective: Chronic rhinosinusitis (CRS) is one of the most common chronic inflammatory diseases. The effect of chronic inflammation caused by CRS on the occurrence of various cancers has not been thoroughly evaluated. This study aimed to investigate the increased incidences of 10 types of cancers among CRS patients with/without nasal polyps (NP) using a national population-based database from the Korean Health Insurance Review and Assessment Service. Read More

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Minimal residual disease assessment of papillary thyroid carcinoma through circulating tumor cell-based cytology.

Cancer Med 2022 May 18. Epub 2022 May 18.

BioNEM Laboratory and Nanotechnology Research Center, Department of Experimental and Clinical Medicine, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.

The overall estimated risk of recurrence after an apparently complete thyroid cancer resection ranges from <1% to 55%, and the high-quality pathology report is crucial for proper risk stratification. The neck ultrasound (US) and serum thyroglobulin (Tg) and anti-Tg antibody (TgAb) assays are the mainstays for Differentiated Thyroid Cancer (DTC) follow-up. However, the neck US includes a high frequency of nonspecific findings and despite the serum, Tg unmasks the presence of thyrocytes, it is not discriminating between normal and malignant cells. Read More

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Clinical analysis of 2860 cases of diabetes in pregnancy: a single-center retrospective study.

BMC Pregnancy Childbirth 2022 May 18;22(1):418. Epub 2022 May 18.

Department of Obstetrics, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.

Background: To investigate the epidemiological, clinical characteristics and outcomes of diabetes in pregnancy (DIP).

Methods: This single-center, retrospective study included 16,974 pregnant women hospitalized during 2018-2019. Among them, 2860 DIP patients were grouped according to diabetes type, glycemic status, and insulin use. Read More

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Differentiated thyroid carcinoma in the elderly: influence of age on disease-free and overall survival.

Endocrine 2022 May 18. Epub 2022 May 18.

Department of Endocrinology, Complejo Hospitalario de Toledo, Toledo, Spain.

Purpose: We investigated whether age at diagnosis of differentiated thyroid carcinoma (DTC) may be a risk factor for structural disease and mortality after primary treatment in aging patients.

Methods: A multicenter, retrospective analysis including patients older than 60 years at DCT diagnosis was designed. All subjects were treated by surgery with or without radioiodine adjuvant therapy and had a minimum follow-up of one year. Read More

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Schilddrüsenknoten: Die Form verrät das Krebsrisiko.

Elke Oberhofer

MMW Fortschr Med 2022 May;164(10):10

Springer Medizin Verlag GmbH, Aschauer Str. 30, 81549, München, Germany.

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Vocal cord augmentation with autogenous SVF-gel injection for treating glottis incompetence: The first ultrasound-guided case.

Asian J Surg 2022 May 15. Epub 2022 May 15.

Breast and Thyroid Disease Center, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), 563000, Zunyi, China. Electronic address:

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Ultrasound classification of thyroid nodules: does size matter?

Einstein (Sao Paulo) 2022 16;20:eAO6747. Epub 2022 May 16.

Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.

Objective: To determine whether the size of thyroid nodules in ACR-TIRADS ultrasound categories 3 and 4 is correlated with the Bethesda cytopathology classification.

Methods: Thyroid nodules (566) subclassified as ACR-TIRADS 3 or 4 were divided into three size categories according to American Thyroid Association guidelines. The frequency of different Bethesda categories in each size range within ACR-TIRADS 3 and 4 classifications was analyzed. Read More

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USP13 genetics and expression in a family with thyroid cancer.

Endocrine 2022 May 18. Epub 2022 May 18.

Group for Advanced Molecular Investigation (NIMA), Graduate Program in Health Sciences (PPGCS), School of Medicine (EM), Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba, Brazil.

Purpose: Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma and its incidence has greatly increased in the last 30 years. Ubiquitin-specific protease 13 (USP13) is a class of deubiquitinating enzymes (DUBs) and plays an important role in cellular functions such as cell cycle regulation, DNA damage repair, and different cell signaling pathways. Studies regarding the role of USP13 in cancer development and progression are divergent and there are no previous data regarding the role of USP13 gene in PTCs. Read More

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External Validation of Three Available Grading Systems for Medullary Thyroid Carcinoma in a Single Institution Cohort.

Endocr Pathol 2022 May 18. Epub 2022 May 18.

Pathology Unit, "Città Della Salute E Della Scienza" Hospital, Turin, Italy.

Medullary thyroid carcinoma (MTC) is a rare thyroid carcinoma with a variable clinical behavior. Potential clinical and pathological prognostic markers have been investigated, but studies are limited and controversial. In neuroendocrine neoplasms of various other sites, necrosis and proliferation (mitotic activity and/or Ki67 index) are integrated to provide a histological grade. Read More

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Well-Differentiated Thyroid Cancer: Who Should Get Postoperative Radiation?

Ann Surg Oncol 2022 May 18. Epub 2022 May 18.

Department of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: The mainstay of treatment of well-differentiated thyroid cancer (WDTC) is surgery followed by adjuvant radioactive iodine therapy. Postoperative radiation therapy (PORT) is rarely used.

Objective: The aim of our study was to report our experience of patients with WDTC who were selected to receive PORT. Read More

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An Evaluation of Clinical Efficacy of Immune Checkpoint Inhibitors for Patients with Anaplastic Thyroid Carcinoma.

Thyroid 2022 May 18. Epub 2022 May 18.

The Ohio State University Comprehensive Cancer Center Arthur G James Cancer Hospital and Richard J Solove Research Institute, 24600, 460 W. 10th Avenue Columbus, Columbus, Ohio, United States, 43210-1240;

Background: Anaplastic thyroid cancer (ATC) is an aggressive thyroid malignancy which is associated with a poor prognosis. Current treatment options include surgery, radiation, cytotoxic chemotherapy, and multikinase inhibitor therapy. The role of immunotherapy in ATC is an area of active interest and recent evidence suggests that it may be a potentially effective treatment option. Read More

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Predictive Value of C2HEST Score for Atrial Fibrillation Recurrence Following Successful Cryoballoon Pulmonary Vein Isolation in Paroxysmal Atrial Fibrillation.

Angiology 2022 May 18:33197221102230. Epub 2022 May 18.

Department of Cardiology, 147003Bursa Yüksek İhtisas Training and Research Hospital, İzmir, Turkey.

The C2HEST score ((coronary artery disease (CAD) or chronic obstructive pulmonary disease (COPD) [C2, 1 point each]; hypertension [H, 1 point]; elderly [E, age ≥75 years, 2 points]; systolic heart failure [S, 2 points]; thyroid disease [T, hyperthyroidism, 1 point]) has been validated for predicting incidental atrial fibrillation (AF) in both the general population and patients with ischemic stroke. The present study evaluated the performance of this score in predicting AF recurrence in 252 patients following cryoballoon ablation (CRYO) for paroxysmal AF. The AF recurrence rate in 3-12 months following CRYO was 20,2%. Read More

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Proteus-Like Syndrome: A Rare Phenotype of Phosphatase and Tensin Homolog Hamartoma Tumor Syndrome.

Cureus 2022 Apr 14;14(4):e24135. Epub 2022 Apr 14.

Radiology, University of Toledo Medical Center, Toledo, USA.

The phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome (PHTS) is a collection of diseases stemming from mutations in the PTEN tumor suppressor gene and is characterized by variable expressivity and abnormal overgrowth in multiple body systems. Its clinical manifestations include, but are not limited to, lipomas, limb overgrowth, dermatologic lesions, and malignancy. The infrequency of occurrence and broadness of clinical presentation has made the diagnosis and differentiation of different subtypes of PHTS challenging. Read More

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Prevalence of hypothyroidism and effect of thyroid hormone replacement therapy in patients with non-alcoholic fatty liver disease: A population-based study.

World J Hepatol 2022 Mar;14(3):551-558

Department of Digestive Disease and Surgery Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, United States.

Background: Non-alcoholic fatty liver disease (NAFLD) is currently considered as the most common cause of chronic liver disease worldwide. Risk factors for NAFLD have been well-described, including obesity, type 2 diabetes mellites (T2DM), dyslipidemia (DLP) and metabolic syndrome. Hypothyroidism has been identified as an independent risk factor for the development of NAFLD, although the literature is inconsistent. Read More

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Concomitant myocarditis and painless thyroiditis after AstraZeneca coronavirus disease 2019 vaccination: a case report.

J Med Case Rep 2022 May 17;16(1):212. Epub 2022 May 17.

Division of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Cardiac Center, King Chulalongkorn Memorial Hospital, Bangkok, 10330, Thailand.

Background: Incidence of myocarditis following messenger RNA coronavirus disease 2019 vaccination has been widely described, but this clinical scenario after adenoviral vector coronavirus disease 2019 vaccination has only been rarely reported. In addition, a few case reports of thyroiditis after adenoviral vector coronavirus disease 2019 vaccination have been published.

Case Presentation: A 55-year-old Thai woman presented with palpitation without neck pain 14 days after receiving AstraZeneca coronavirus disease 2019 vaccination. Read More

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