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    Significance of parathyroid scintigraphy and correlation of findings with parathyroid hormone values in patients undergoing hemodialysis.
    Med Glas (Zenica) 2017 Aug 1;14(2). Epub 2017 Aug 1.
    Clinic for Gynecology and Obstetrics, University Clinical Center Sarajevo; Bosnia and Herzegovina.
    Aim To compare finding of thyroid gland scintigraphy with serum concentration of parathyroid hormone in patients undergoing hemodialysis. Methods This retrospective-prospective study included 50 patients undergoing hemodialysis with established hyperparathyroidism who were treated at Cantonal Hospital Zenica in the period 2009 - 2014. Besides anthropological data, concentration of parathyroid hormone in serum of patients was monitored too. Read More

    Periodic Paralysis and Encephalopathy as Initial Manifestations of Graves' Disease: Case Report and Review of the Literature.
    Neurologist 2017 Jul;22(4):134-137
    *Neurology Department, Papageorgiou General Hospital ‡Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece †Department of Clinical Neurophysiology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
    Background: Thyrotoxic periodic paralysis (TPP) is an uncommon complication of Graves' disease, characterized by the triad of acute hypokalemia without total body potassium deficit, episodic muscle paralysis, and thyrotoxicosis. Graves' encephalopathy is an extremely rare form of encephalopathy associated with autoimmune thyroid disease (EAATD), characterized by neuropsychiatric symptoms, increased antithyroid antibodies and cerebrospinal fluid protein concentration, nonspecific electroencephalogram abnormalities, and cortico-responsiveness. Coexistence of both these complications in the same patient has not been reported before. Read More

    Significance of expression of suppressor of cytokine signaling proteins: Suppressor of cytokine signaling-1, suppressor of cytokine signaling-2, and suppressor of cytokine signaling-3 in papillary thyroid cancer.
    J Cancer Res Ther 2017 Apr-Jun;13(2):337-345
    Division of Molecular Endocrinology, Department of Cancer Biology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India.
    Purpose: Uncontrolled cytokine signal transduction largely associated with oncogene activation, can have disastrous biological consequences. The suppressor of cytokine signaling (SOCS) proteins represent one of the mechanisms by which this rampant signaling can be dissipated. Thus, we aimed to study the expression of SOCS-1, SOCS-2, and SOCS-3 in patients having benign thyroid disease and papillary thyroid cancer. Read More

    Application of transoral continuous intraoperative neuromonitoring in natural orifice transluminal endoscopic surgery for thyroid disease: a preliminary study.
    Surg Endosc 2017 Jun 22. Epub 2017 Jun 22.
    Superintendent's Office, Chi-Mei Hospital Chiali, Chiali 606, Shin-Hwa Road, Chiali District, Tainan, 722, Taiwan.
    Background: The novel concept of continuous intraoperative neuromonitoring (Cont-IONM) through stimulation of the vagal nerve has been used in thyroidectomies to prevent imminent injury of the recurrent laryngeal nerve (RLN). This article reports on this technology and the results of using transoral Cont-IONM in natural orifice transluminal endoscopic surgery for thyroid disease.

    Methods: Cont-IONM of the RLN was achieved through automatic cyclical stimulation of the vagal nerve using a C2 monitor and delta stimulating electrode. Read More

    Inclusion Body Myositis: A Case Presenting with Respiratory Failure and Autopsy Findings Leading to the Hypothesis of a Paraneoplastic Cause.
    Am J Case Rep 2017 Jun 23;18:700-706. Epub 2017 Jun 23.
    SUNY Downstate Medical Center, Brooklyn, NY, USA.
    BACKGROUND Sporadic inclusion body myositis (IBM) is the most common acquired myopathy seen in adults aged over 50 years, with a prevalence estimated at between 1 and 70 per million. Weakness of the diaphragm with loss of vital capacity is almost universal in IBM. This is almost always asymptomatic. Read More

    Development of a Tailored Thyroid Gland Phantom for Fine-Needle Aspiration Cytology by Three-Dimensional Printing.
    J Surg Educ 2017 Jun 19. Epub 2017 Jun 19.
    Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Medical-Engineering, Hybrid Professional Development Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. Electronic address:
    Background: Fine-needle aspiration cytology (FNAC) is a challenging and risky procedure for inexperienced clinicians to perform because of the proximity of the thyroid to the jugular veins, carotid arteries, and trachea. A phantom model for transfixion practice would help train clinicians in FNAC.

    Objective: To fabricate a tailored phantom with consideration for authenticity of size, touch, feel, and ultrasonographic (US) characteristics. Read More

    Thyrotoxic and pheochromocytoma multisystem crisis: a case report.
    J Med Case Rep 2017 Jun 23;11(1):173. Epub 2017 Jun 23.
    Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
    Background: Thyrotoxic crisis and pheochromocytoma multisystem crisis are rare, life-threatening, emergency endocrine diseases with various clinical manifestations. Here we report a case of a patient who simultaneously developed thyrotoxic crisis and pheochromocytoma multisystem crisis and required intensive cardiovascular management.

    Case Presentation: A 60-year-old Asian man experienced nausea and vomiting, and subsequently developed dyspnea and cold sweats while farming. Read More

    Thyroid autoimmunity in bipolar disorder: A systematic review.
    J Affect Disord 2017 Jun 13;221:97-106. Epub 2017 Jun 13.
    Bipolar Disorders Unit, Clinical Institute of Neurosciences, Hospital Clinic, IDIBAPS, University of Barcelona, CIBERSAM, Barcelona, Catalonia, Spain.
    Background: Accumulating evidence points to the pathophysiological relevance between immune dysfunction and mood disorders. High rates of thyroid dysfunction have been found in patients with bipolar disorder (BD), compared to the general population. A systematic review of the relationship between BD and thyroid autoimmunity was performed. Read More

    A PRISMA-compliant systematic review and meta-analysis of the relationship between thyroid disease and different levels of iodine intake in mainland China.
    Medicine (Baltimore) 2017 Jun;96(25):e7279
    Department of Nuclear Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
    Background: Low-iodine intake has historically been an issue in China, causing widespread iodine deficiency diseases (IDD). China started to introduce universal salt iodization in 1995, but reports of increased thyroid disease are a concern and appropriate levels of iodine intake must be considered.

    Objective: To assess the prevalence of thyroid disease with different urinary iodine concentrations (UICs) in the general population of those residing in mainland China. Read More

    Is selenium supplementation in autoimmune thyroid diseases justified?
    Curr Opin Endocrinol Diabetes Obes 2017 Jul 20. Epub 2017 Jul 20.
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark.
    Purpose Of Review: This review provides an appraisal of recent evidence for or against selenium supplementation in patients with autoimmune thyroid diseases, and discusses possible effect mechanisms.

    Recent Findings: Epidemiological data suggest an increased prevalence of autoimmune thyroid diseases under conditions of low dietary selenium intake. Two systematic reviews have evaluated controlled trials among patients with autoimmune thyroiditis and report that selenium supplementation decreases circulating thyroid autoantibodies. Read More

    Cushing Syndrome: Diagnostic Workup and Imaging Features, With Clinical and Pathologic Correlation.
    AJR Am J Roentgenol 2017 Jul;209(1):19-32
    1 Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030.
    Objective: Cushing syndrome (CS) is a constellation of clinical signs and symptoms resulting from chronic exposure to excess cortisol, either exogenous or endogenous. Exogenous CS is most commonly caused by administration of glucocorticoids. Endogenous CS is subdivided into two types: adrenocorticotropic hormone (ACTH) dependent and ACTH independent. Read More

    Discovery of novel wtRET and V804MRET inhibitors: from hit to lead.
    ChemMedChem 2017 Jun 22. Epub 2017 Jun 22.
    University of Padova, Pharmaceutical Sciences, via Marzolo 5, I-35131, Padova, ITALY.
    Oncogenic activation of the RET kinase has been found in several neoplastic diseases, like medullary thyroid carcinoma, multiple endocrine neoplasia, papillary thyroid carcinoma and non-small cells lung cancer. Currently approved RET inhibitors were not originally designed to be RET inhibitors and their potency against RET kinase has not been optimized. Hence, novel compounds able to inhibit both wtRET and its mutants (e. Read More

    The cell biology of the thyroid-disrupting mechanism of dichlorodiphenyltrichloroethane (DDT).
    J Endocrinol Invest 2017 Jun 21. Epub 2017 Jun 21.
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
    Objective: Dichlorodiphenyltrichloroethane (DDT) is an organochlorine known for its pesticide properties and for its negative effects on human health. It was banned in most countries for its toxicity to the endocrine system, but due to its persistence at clinically relevant concentrations in both soil and animal tissues, DDT is still linked to several health and social problems.

    Methods: We have previously shown that DDT exposure is causally related to the extracellular release of vesicular organelles such as microvesicles and/or exosomes by using immunocytochemistry with gold-tagged antibodies and various fluorescent membrane markers. Read More

    POEMS syndrome: a rare cause of exudative ascites and chronic peripheral neuropathy.
    BMJ Case Rep 2017 Jun 20;2017. Epub 2017 Jun 20.
    Neurology Department, Rashid Hospital, Dubai, UAE.
    POEMS syndrome (Peripheral neuropathy, Organomegaly, Endocrinopathy, M protein, Skin changes) is a rare plasma cell disorder with multisystem involvementA 40-year-old man with a chronic history of unexplained peripheral neuropathy , presented with exudative ascites.He was found to have an incidental osteolytic lesion of the sacrum proven to be a plasmacytoma. Immunoelectrophoresis for monoclonal protein was negative. Read More

    Role of the tumour necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) axis in autoimmune thyroid disease.
    Clin Endocrinol (Oxf) 2017 Jun 21. Epub 2017 Jun 21.
    Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, P.R. China, 110001.
    Background: TNF-like weak inducer of apoptosis (TWEAK), its receptor fibroblast growth factor-inducible 14 (Fn14) and its scavenger receptor CD163 (sCD163) have known associations with many autoimmune diseases. However, the role of the TWEAK axis in autoimmune thyroid disease (AITD) remains unclear. Therefore, the aim of this study was to investigate the role of the TWEAK-Fn14 axis in the pathogenesis of AITD. Read More

    Rethinking the Current American Joint Committee on Cancer TNM Staging System for Medullary Thyroid Cancer.
    JAMA Surg 2017 Jun 21. Epub 2017 Jun 21.
    Department of Surgery, Duke University Medical Center, Durham, North Carolina3Duke Cancer Institute, Durham, North Carolina4Duke Clinical Research Institute, Durham, North Carolina5Deputy Editor, JAMA Surgery.
    Importance: Controversy exists around the American Joint Committee on Cancer (AJCC) TNM staging system for medullary thyroid cancer (MTC). Because of the rarity of the disease and limited available data, the staging system for MTC has been largely extrapolated from staging for differentiated thyroid cancer.

    Objectives: To evaluate how well the current (seventh and eighth editions) AJCC TNM staging system correlates with survival for patients with MTC and to suggest a possible revision. Read More

    Evaluation of molecular diagnostic approaches for the detection of BRAF p.V600E mutations in papillary thyroid cancer: Clinical implications.
    PLoS One 2017 21;12(6):e0179691. Epub 2017 Jun 21.
    Oncology Clinic, Holycross Cancer Centre, Kielce, Poland.
    Differentiated papillary thyroid cancer (PTC) is the most common cancer of the endocrine system. PTC has a very good prognosis and a high 5 year survival rate; however, some patients are unresponsive to treatment, and their diagnosis eventually results in death. Recent efforts have focused on searching for prognostic and predictive factors that may enable treatment personalization and monitoring across the course of the disease. Read More

    Surgical management for follicular variant of papillary thyroid carcinoma.
    Oncotarget 2017 Jun 16. Epub 2017 Jun 16.
    Department of Breast and Thyroid Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, P.R. China.
    Background And Aims: For most patients with follicular variant of papillary thyroid carcinoma (FVPTC), surgery is required, while the surgical management remains controversial. We aim to further understanding of treatment of FVPTC and to determine whether specific features could be identified for the decision of surgical strategy.

    Materials And Methods: Data were obtained from the Surveillance, Epidemiology, and End Results (SEER) Program database during 2003 and 2013. Read More

    New Insights in Thyroid Cancer and p53 Family Proteins.
    Int J Mol Sci 2017 Jun 21;18(6). Epub 2017 Jun 21.
    Department of Clinical and Experimental Medicine, University of Catania, 95124 Catania, Italy.
    Thyroid cancers are common endocrine malignancies that comprise tumors with different clinical and histological features. Indeed, papillary and follicular thyroid cancers are slow-growing, well-differentiated tumors, whereas anaplastic thyroid cancers are undifferentiated neoplasias that behave much more aggressively. Well-differentiated thyroid carcinomas are efficiently cured by surgery and radioiodine, unlike undifferentiated tumors that fail to uptake radioactive iodine and are usually resistant to chemotherapy. Read More

    GC-1: a thyromimetic with multiple therapeutic applications in liver disease.
    Gene Expr 2017 Jun 13. Epub 2017 Jun 13.
    Department of Biomedical Sciences, Unit of Oncology and Molecular Pathology, University of Cagliari, Cagliari, Italy.
    Thyroid hormones, namely 3,5,3'-triiodo-L-thyronine (T3) and 3,5,3',5'-tetraiodo-L-thyronine (thyroxine or T4), influence a variety of physiological processes that have important implications in fetal development, metabolism, cell growth and proliferation. While THs elicit several beneficial effects on lipid metabolism and improve myocardial contractility, these therapeutically desirable effects are associated to a thyrotoxic state, that severely limits the possible use of THs as therapeutic agents. Therefore, several efforts have been made to develop T3 analogues that could retain the beneficial actions (triglyceride, cholesterol, obesity and body mass lowering), without the adverse TH-dependent side effects. Read More

    Comparison of the 7th and 8th Editions of the AJCC/UICC TNM Staging System for Differentiated Thyroid Cancer.
    Thyroid 2017 Jun 21. Epub 2017 Jun 21.
    Asan Medical Center, Uinversity of Ulsan College of Medicine, Internal Medicine, Seoul, Korea (the Republic of) ;
    Objective: To evaluate the efficacy and prognostic validity for disease-specific survival (DSS) of the 8th edition American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) tumor-node-metastasis (TNM) staging system (TNM-8) compared with the 7th edition (TNM-7) in patients with differentiated thyroid carcinoma (DTC).

    Methods: The 7th and 8th editions of the TNM staging system were applied to 1613 DTC patients who underwent thyroid surgery between 1996 and 2003. We evaluated the proportion of variation explained (PVE) and Harrell's c-index to compare the predictive capability of DSS. Read More

    Sorafenib in Japanese Patients With Locally Advanced or Metastatic Medullary Thyroid Carcinoma and Anaplastic Thyroid Carcinoma.
    Thyroid 2017 Jun 21. Epub 2017 Jun 21.
    Bayer Yakuhin, Ltd., 8Medical Affairs, Oncology and Hematology, and Clinical Development, Specialty Medicine, Tokyo, Japan ;
    Background: Therapeutic options for treating advanced or metastatic medullary thyroid carcinoma (MTC) and anaplastic thyroid carcinoma (ATC) are still limited in Japan even though vandetanib for MTC, and lenvatinib for MTC and ATC have been approved. Sorafenib is an oral multikinase inhibitor approved for the treatment of patients with radioactive iodine-refractory (RAI-R) differentiated thyroid cancer (DTC). We conducted an uncontrolled, open-label, multicenter, single-arm, phase 2 clinical study to evaluate the safety and efficacy of sorafenib in Japanese patients with MTC and ATC. Read More

    [RET/PTC rearrangement affects multifocal formation of papillary thyroid carcinoma].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Jun;52(6):435-439
    Department of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
    Objective:RET/PTC gene rearrangement can lead to aberrant activation of tyrosine kinase receptors, which is a common mutation in papillary thyroid carcinoma (PTC). This study focuses on the association of RET/PTC rearrangements with PTC clinical factors. Methods: From January 2011 to December 2013, a total of 114 patients with PTC were enrolled in this study. Read More

    [Retrospective comparison of screening criteria for active surveillance for papillary thyroid microcarcinoma].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Jun;52(6):430-434
    Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
    Objective: To investigate the rationality of management of active surveillance for papillary thyroid microcarcinoma (PTMC) and the main indications for active surveillance for PTMC. Methods: In this study, two criteria were used to evaluate patients with PTMC: low-risk PTMC conditions defined by Kuma hospital and Chinese Association of Thyroid Oncology (CATO) consensus on PTMC management of active surveillance. The patients had received surgical treatment. Read More

    Demographic characteristics and pregnancy outcomes in adolescents - Experience from an Australian perinatal centre.
    Aust N Z J Obstet Gynaecol 2017 Jun 20. Epub 2017 Jun 20.
    Mater Research Institute, University of Queensland, South Brisbane, QLD, Australia.
    Background: Adolescent pregnancy is defined as pregnancy in girls aged 10-19 years and can be associated with increased risks.

    Aim: To investigate obstetric and perinatal outcomes in a cohort of adolescent girls from a major Australian tertiary centre.

    Materials And Methods: This was a nine-year retrospective cohort study of women who birthed at the Mater Mother's Hospital (MMH) in Brisbane, Australia between 1 January 2007 and 31 December 2015. Read More

    Primary squamous cell carcinoma of the thyroid: Case report and systematic review of the literature.
    Int J Surg Case Rep 2017 Jun 13;37:36-40. Epub 2017 Jun 13.
    Clinic for Visceral, General and Transplant Surgery, Tuebingen University Hospital, Germany. Electronic address:
    Background: Primary squamous cell cancer (PSCC) of thyroid is a rare malignancy with poor prognosis. It is mandatory to exclude secondary involvement of the thyroid by panendoscopy, CT-scan and immunohistochemical analysis. As treatment surgery, radiation and rarely chemotherapy is employed. Read More

    Citrobacter freundii as a cause of acute suppurative thyroiditis in an immunocompetent adult female.
    Indian J Pathol Microbiol 2017 Apr-Jun;60(2):282-284
    Department of Otorhinolaryngology, Government Medical College Hospital, Chandigarh, India.
    Acute suppurative thyroiditis (AST) is an uncommon condition, in the patients with preexisting thyroid disease or immunosuppression. The most common cause of AST is bacterial, and the most common bacteria are Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Klebsiella species. Due to various complications such as septicemia, septic thrombophlebitis, necrotizing mediastinitis, or pericarditis, prompt diagnosis and treatment are the keys to reduce mortality and morbidity. Read More

    The absence of CD56 expression can differentiate papillary thyroid carcinoma from other thyroid lesions.
    Indian J Pathol Microbiol 2017 Apr-Jun;60(2):161-166
    Department of Pathology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
    Context: The neural cell adhesion molecule CD56 is an antigen important for the differentiation of the follicular epithelium. Recent studies have reported low or absent expression of CD56 in papillary thyroid carcinoma (PTC) and its presence in normal thyroid tissue, benign thyroid lesions, and most follicular non-PTC tumors.

    Aim: We wish to estimate the value of CD56 in the differentiation of PTC (including follicular variant-PTC [FV-PTC]) from other nontumoral lesions and follicular thyroid neoplasias. Read More

    Definition of the upper reference limit for thyroglobulin antibodies according to the National Academy of Clinical Biochemistry guidelines: comparison of eleven different automated methods.
    Auto Immun Highlights 2017 Dec 19;8(1). Epub 2017 Jun 19.
    Clinical Pathology Laboratory, 'S. Maria degli Angeli' Hospital, Pordenone, Italy.
    Purpose: In the last two decades, thyroglobulin autoantibodies (TgAb) measurement has progressively switched from marker of thyroid autoimmunity to test associated with thyroglobulin (Tg) to verify the presence or absence of TgAb interference in the follow-up of patients with differentiated thyroid cancer. Of note, TgAb measurement is cumbersome: despite standardization against the International Reference Preparation MRC 65/93, several studies demonstrated high inter-method variability and wide variation in limits of detection and in reference intervals. Taking into account the above considerations, the main aim of the present study was the determination of TgAb upper reference limit (URL), according to the National Academy of Clinical Biochemistry guidelines, through the comparison of eleven commercial automated immunoassay platforms. Read More

    Thyrotoxic periodic paralysis as an initial presentation of Graves' disease in a Saudi patient.
    BMJ Case Rep 2017 Jun 19;2017. Epub 2017 Jun 19.
    Department of Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
    Thyrotoxic periodic paralysis (TPP) is a well-known complication of hyperthyroidism, characterised by recurrent flaccid paralysis with hypokalaemia. To date, only five cases of this rare disorder have been reported in Saudi Arabia. Here, we report an additional case involving a 25-year-old Saudi man who presented with lower limb paralysis and severe hypokalaemia. Read More

    Preoperative embolization in spinal tumour surgery: Enhancing its effectiveness.
    J Clin Neurosci 2017 Jun 16. Epub 2017 Jun 16.
    Department of Diagnostic Imaging, National University Hospital, Singapore 119074, Singapore.
    We conducted a retrospective review of 221 patients, who underwent spinal oncologic surgery at a tertiary university hospital between 2005 and 2014; in order to identify and validate factors that influence the impact of preoperative embolization of spinal tumours on outcome measures of blood loss and transfusion requirements in spinal oncologic surgery. We also focused on primary tumour type and type of spinal surgery performed. Patients' electronic and physical records were reviewed to provide demographic data, tumour characteristics, embolization techniques and surgical procedure details. Read More

    Insights into the management of papillary microcarcinoma of the thyroid.
    Thyroid 2017 Jun 19. Epub 2017 Jun 19.
    Kuma Hospital, Department of Surgery , Shimoyamate-dori, Chuo-ku, Kobe , Kobe, Japan , 6500011 ;
    Background: Rapid increases in the incidence of thyroid carcinoma with stable mortality rates from thyroid carcinoma have been reported from many countries, and these increases are thought to be due mostly to the increased detection of small papillary thyroid carcinomas (PTCs), including papillary microcarcinomas (PMCs, i.e., PTCs ≤10 mm). Read More

    Differentiated Thyroid Cancer-Treatment: State of the Art.
    Int J Mol Sci 2017 Jun 17;18(6). Epub 2017 Jun 17.
    Department of Nuclear Medicine, University of Regensburg, 93053 Regensburg, Germany.
    Differentiated thyroid cancer (DTC) is a rare malignant disease, although its incidence has increased over the last few decades. It derives from follicular thyroid cells. Generally speaking, the prognosis is excellent. Read More

    Polybrominated diphenyl ethers (PBDEs) and thyroid hormones in cord blood.
    Environ Pollut 2017 Jun 16;229:489-495. Epub 2017 Jun 16.
    Department of Pediatrics, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:
    Human exposure to polybrominated diphenyl ethers (PBDEs) has been increasing over the last three decades in China and around the world. Animal studies suggest that PBDEs could reduce blood levels of thyroid hormones, but it is unclear whether PBDEs disrupt thyroid function in humans. We used data from a prospective birth cohort of 123 pregnant women who were enrolled between September 2010 and March 2011 in Shandong, China. Read More

    Alterations in AQP4 expression and polarization in the course of motor neuron degeneration in SOD1G93A mice.
    Mol Med Rep 2017 Jun 15. Epub 2017 Jun 15.
    Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China.
    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective degeneration of upper and lower motor neurons. The disease progression is associated with the astrocytic environment. Aquaporin-4 (AQP4) water channels are the most abundant AQPs expressed in astrocytes, exerting important influences on central nervous system homeostasis. Read More

    Maternal autoimmune disorders and fetal defects.
    J Matern Fetal Neonatal Med 2017 Jun 18:1-9. Epub 2017 Jun 18.
    a Fetal Medicine Research Institute , King's College Hospital , London , UK.
    Maternal autoantibodies can cross the placenta and cause fetal damage. This article summarizes the development and management of fetal thyroid goiter in response to maternal Graves' disease and/or its treatment with antithyroid medication, fetal heart block due to maternal anti-Ro and anti-La antibodies, fetal athrogryposis multiplex congenita in association with maternal myasthenia gravis and fetal brain hemorrhage due to maternal autoimmune thrombocytopenia. Read More

    Analysis of PTPN22, ZFAT and MYO9B polymorphisms in Turner Syndrome and risk of autoimmune disease.
    Int J Immunogenet 2017 Jun 18. Epub 2017 Jun 18.
    Human Genetic Department, Hospital General de México Eduardo Liceaga, Mexico City, Mexico.
    Turner syndrome (TS) is one of the most common sexual chromosome abnormalities and is clearly associated with an increased risk of autoimmune diseases, particularly thyroid disease and coeliac disease (CD). Single-nucleotide polymorphism analyses have been shown to provide correlative evidence that specific genes are associated with autoimmune disease. Our aim was to study the functional polymorphic variants of PTPN22 and ZFAT in relation to thyroid disease and those of MYO9B in relation to CD. Read More

    Graves' disease with severe neutropenia: any clues?
    Clin Endocrinol (Oxf) 2017 Jun 19. Epub 2017 Jun 19.
    Medical Department, Al Adan Hospital, Kuwait.
    In volume 85, issue 6 of "Clinical Endocrinology", Aggarwal, et al. published a study titled "Treatment of Hyperthyroidism With Antithyroid Drugs Corrects Mild Neutropenia in Graves' Disease". The authors treated Graves' disease (GD) with mild neutropenia using a thionamide anti-thyroid drug (ATD). Read More

    Autoimmune Thyroiditis and Glomerulopathies.
    Front Endocrinol (Lausanne) 2017 2;8:119. Epub 2017 Jun 2.
    Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Autoimmune thyroiditis (AIT) is generally associated with hypothyroidism. It affects ~2% of the female population and 0.2% of the male population. Read More

    Influence of chronic lymphocytic thyroiditis on the risk of persistent and recurrent disease in patients with papillary thyroid carcinoma and elevated antithyroglobulin antibodies after initial therapy.
    Braz J Otorhinolaryngol 2017 Jun 2. Epub 2017 Jun 2.
    Santa Casa de Belo Horizonte, Serviço de Endocrinologia, Belo Horizonte, MG, Brazil.
    Introduction: In patients with papillary thyroid carcinoma who have negative serum thyroglobulin after initial therapy, the risk of structural disease is higher among those with elevated antithyroglobulin antibodies compared to patients without antithyroglobulin antibodies. Other studies suggest that the presence of chronic lymphocytic thyroiditis is associated with a lower risk of persistence/recurrence of papillary thyroid carcinoma.

    Objective: This prospective study evaluated the influence of chronic lymphocytic thyroiditis on the risk of persistence and recurrence of papillary thyroid carcinoma in patients with negative thyroglobulin but elevated antithyroglobulin antibodies after initial therapy. Read More

    [Algorithms based on medico-administrative data in the field of endocrine, nutritional and metabolic diseases, especially diabetes].
    Rev Epidemiol Sante Publique 2017 Jun 15. Epub 2017 Jun 15.
    Caisse nationale d'assurance maladie des travailleurs salariés, 75020 Paris, France.
    Background: Medico-administrative databases represent a very interesting source of information in the field of endocrine, nutritional and metabolic diseases. The objective of this article is to describe the early works of the Redsiam working group in this field.

    Methods: Algorithms developed in France in the field of diabetes, the treatment of dyslipidemia, precocious puberty, and bariatric surgery based on the National Inter-schema Information System on Health Insurance (SNIIRAM) data were identified and described. Read More

    Sialadenoma papilliferum in the buccal mucosa detected on (18)F-fluorodeoxyglucose-positron emission tomography.
    Br J Oral Maxillofac Surg 2017 Jun 15. Epub 2017 Jun 15.
    Department of Oral Maxillofacial Surgery, Tokyo Medical University Hospital, 6-7-1, Shinjuku, Tokyo, Japan. Electronic address:
    An incidental discovery of an accumulation of (18)F-fluorodeoxyglucose (FDG) in the oral cavity of patients with malignant tumours on FDG positron emission tomography (PET) can pose a problem regarding the differential diagnosis of metastatic lesions. Large accumulations can often be found even when tumours in the salivary or thyroid gland are benign, so FDG-PET is limited in its ability to differentiate between benign and malignant disease. This report describes a rare case of sialadenoma papilliferum in the buccal mucosa that was discovered incidentally on FDG-PET in a patient with multiple metastases to bone after an operation for rectal cancer. Read More

    Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors.
    Bioorg Med Chem Lett 2017 May 26. Epub 2017 May 26.
    Department of Biochemistry & Molecular Biology, Indiana University, School of Medicine, Van Nuys Medical Sciences Building, MS 0013D, 635 Barnhill Dr, Indianapolis, IN 46202, United States. Electronic address:
    Rate-limiting dissociation of the tetrameric protein transthyretin (TTR), followed by monomer misfolding and misassembly, appears to cause degenerative diseases in humans known as the transthyretin amyloidoses, based on human genetic, biochemical and pharmacologic evidence. Small molecules that bind to the generally unoccupied thyroxine binding pockets in the native TTR tetramer kinetically stabilize the tetramer, slowing subunit dissociation proportional to the extent that the molecules stabilize the native state over the dissociative transition state-thereby inhibiting amyloidogenesis. Herein, we use previously reported structure-activity relationship data to develop two semi-quantitative algorithms for identifying the structures of potent and selective transthyretin kinetic stabilizers/amyloidogenesis inhibitors. Read More

    DICER1 mutations in twelve Chinese patients with pleuropulmonary blastoma.
    Sci China Life Sci 2017 Jun 14. Epub 2017 Jun 14.
    Center for Clinical Epidemiology & Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
    Our aim is to examine the impact of DICER1 mutations on the pathogenesis of pleuropulmonary blastoma (PPB) by evaluating the mutation frequency and investigating the family history of Chinese patients with PPB. The family histories of 12 children with PPB recruited consecutively were surveyed. Blood samples from patients and their first-degree relatives were tested for DICER1 mutations. Read More

    Retrograde Thyroidectomy for preservation of the External Branch of the Superior Laryngeal Nerve: A case series.
    Int J Surg Case Rep 2017 May 15. Epub 2017 May 15.
    Department of Clinical Surgical Sciences, The University of West Indies, St Augustine, Trinidad and Tobago.
    Background: The external branch of the Superior Laryngeal nerve (EBSLN) is at high risk of injury in surgery for large multinodular goitre (MNG) since the upper pole is high in the neck, well cephalad to the EBSLN. We present a technique of drawing the lobe caudally by retrograde thyroidectomy in order to minimize nerve injury.

    Design & Method: All patients having surgery for benign MNG were included. Read More

    Association between giant cell arteritis and thyroid dysfunction in a "real life" population.
    Endocrine 2017 Jun 16. Epub 2017 Jun 16.
    Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.
    Purpose: Giant cell arteritis is a systemic autoimmune disorder which involves inflammation of medium to large vessels. The association between giant cell arteritis and autoimmune thyroid disorders has been investigated numerous times in the literature with inconsistent results. Our objective was to evaluate whether a genuine association exists between giant cell arteritis and thyroid dysfunction, which is often due to immune-mediated thyroid disease. Read More

    Delay in diagnosis of celiac disease in patients without gastrointestinal complaints.
    Am J Med 2017 Jun 13. Epub 2017 Jun 13.
    Division of Gastroenterology, Department of Medicine, Loyola University Medical Center Division of Gastroenterology, Department of Medicine, 2160 S. 1(st) Avenue Rm 167, Maywood, IL 60153, Howard University College of Medicine, Washington, DC 20060, United States. Electronic address:
    Purpose: The purpose of our study is to investigate the delay in diagnosis of patients with biopsy-proven celiac disease in those who present with gastrointestinal complaints vs non-gastrointestinal complaints at our tertiary care center. Celiac disease is an autoimmune disorder which affects approximately 1% of the population worldwide. Celiac disease can have variable clinical presentations characterized by either predominately gastrointestinal symptoms or may present without any gastrointestinal symptom. Read More

    Endocrine-disrupting activity of per- and polyfluoroalkyl substances: Exploring combined approaches of ligand and structure based modeling.
    Chemosphere 2017 Jun 9;184:514-523. Epub 2017 Jun 9.
    Interdisciplinary Center for Nanotoxicity, Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS, 39217, USA. Electronic address:
    Exposure to perfluorinated and polyfluoroalkyl substances (PFCs/PFASs), endocrine disrupting halogenated pollutants, has been linked to various diseases including thyroid toxicity in human populations across the globe. PFASs can compete with thyroxine (T4) for binding to the human thyroid hormone transport protein transthyretin (TTR) which may lead to reduce thyroid hormone levels leading to endocrine disrupting adverse effects. Environmental fate and endocrine-disrupting activity of PFASs has initiated several research projects, but the amount of experimental data available for these pollutants is limited. Read More

    Ratio of positive lymph nodes: The prognostic value in stage IV thyroid cancer.
    Oncotarget 2017 Jun 7. Epub 2017 Jun 7.
    Department of Nuclear Medicine, Second Affiliated Hospital, Fujian Medicine University, Licheng, Quanzhou 362000, China.
    To assess the prognostic value of lymph node ratio (LNR) in patients with stage IV thyroid cancer based on the Surveillance, Epidemiology, and End Results (SEER) database. A total of 4,940 eligible patients were included for the analysis. Kaplan-Meier survival analysis and Cox proportional hazard regression were used to reveal the effect of LNR on overall survival (OS) and disease specific survival (DSS). Read More

    Clinical Characteristics and Outcomes of Patients with Ischemic and Non-Ischemic Complete Heart Block.
    Cureus 2017 May 12;9(5):e1244. Epub 2017 May 12.
    Electrophysiology, Fairview Hospital, Cleveland Clinic, USA.
    Introduction: Third degree or complete heart block (CHB) is a medical emergency and usually requires permanent pacemaker placement. CHB can be caused by cardiac ischemia or non-ischemic conditions such as infiltrative diseases or fibrosis. The purpose of this study is to identify the baseline clinical characteristics associated with ischemic versus non-ischemic causes of complete heart block and compare their outcomes. Read More

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