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    1 OF 3188

    Outcomes of patients with bone metastases from differentiated thyroid cancer.
    Arch Endocrinol Metab 2018 Feb;62(1):14-20
    Division of Endocrinology, Hospital de Clínicas, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.
    Objective Bone metastases (BM) from differentiated thyroid cancer (DTC) are associated with poor survival rates. Due to the low frequency of this entity, we performed a multicentric retrospective study that aimed to evaluate the presentation, outcome and causes of death in this population. Subjects and methods We reviewed file records from 10 databases. Read More

    A phase 1 study of cabozantinib in children and adolescents with recurrent or refractory solid tumors, including CNS tumors: Trial ADVL1211, a report from the Children's Oncology Group.
    Pediatr Blood Cancer 2018 Apr 25:e27077. Epub 2018 Apr 25.
    Department of Pediatrics, Hem/Onc/BMT/University of Minnesota/Masonic Cancer Center, Minneapolis, MN, USA.
    Background: We conducted a phase 1 trial to determine the maximum tolerated dose (MTD), toxicity profile, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary activity of cabozantinib in children with refractory or relapsed solid tumors.

    Methods: Patients received cabozantinib tablets on a continuous dosing schedule in a rolling-six escalating phase 1 trial design. PK and PD studies were performed. Read More

    Lnc RNA H19 is associated with poor prognosis in breast cancer patients and promotes cancer stemness.
    Breast Cancer Res Treat 2018 Apr 24. Epub 2018 Apr 24.
    Department of Gastroenterological Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa, 236-0004, Japan.
    Purpose: Aldehyde dehydrogenase1 (ALDH1) is widely accepted as a stem cell marker for normal breast as well as in breast cancer. Although the clinical impact of ALDH1 was observed in our previous study, we do not know how ALDH1 affects stem cell features resulting in worsening of prognosis in breast cancer. The purpose of this study is to explore ALDH1-related gene and its function on cancer stem cell (CSC). Read More

    [Interaction between cigarette smoking and glucocorticoids therapy and therapeutic doses of radioiodine (131I) in patients with Graves’ disease].
    Przegl Lek 2016;73(10):766-72
    The present study evaluated the effects of smoking on the amount of therapeutic doses of radioiodine ((131)I) given to patients with Graves’ disease (GB). The study also retrospectively analyzed the relationship between the onset of symptoms of thyroid ophthalmopathy (OT) after treatment with (131)I within 2 years and changes of TSHR-Abs levels, and the impact of prednisone administration before and after the therapy on OT development in both smoking and non-smoking patients.

    Materials And Methods: The study group included 116 patients, 97 women and 19 men, aged 28 ÷ 77 years (average 51 years) who were diagnosed with GB and treated with therapeutic doses of (131)I. Read More

    Lectin-Like Oxidized Low-Density Lipoprotein Receptor (Lox-1), Thyroid Hormone (T3) And Reactive Oxygen Species (Ros): Possible Cross-Talk In Angiogenesis.
    Theor Biol Forum 2017 Jan 1;110(1-2):13-23. Epub 2017 Jan 1.
    Fondazione CNR/Regione Toscana G. Monasterio, Pisa, Italy.
    Angiogenesis is a physiological process required for embryonic vascular development and involved in the pathophysiological progress of diseases such as atherosclerosis. In fact, hypoxia, ischemia and oxidative stress are common events in atherosclerotic plaque that stimulate angiogenesis, leading to the formation of a neovascularization in the intima of atherosclerotic lesions. The presence of these capillaries favours the progression of the plaque instability. Read More

    [Effects of thyroid hormone on macrophage dysfunction induced by oxidized low-density lipoprotein].
    Sheng Li Xue Bao 2018 Apr;70(2):141-148
    Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China.
    It has been recognized that patients with hypothyroidism have higher risks of atherosclerosis and coronary heart disease, however, the mechanisms are largely unknown. Considering that macrophage dysfunction plays an important role in the formation and development of atherosclerosis plaques, this study aimed to investigate the direct effects of thyroid hormone on macrophage functions and to provide new insight for the mechanism of hypothyroid atherosclerosis. RAW264. Read More

    Metformin targets Mitochondrial Glycerophosphate Dehydrogenase (mGPDH) to control Rate of Oxidative Phosphorylation and growth of thyroid cancer in vitro and in vivo.
    Clin Cancer Res 2018 Apr 24. Epub 2018 Apr 24.
    Metabolic Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases
    Purpose: Mitochondrial glycerophosphate dehydrogenase (mGPDH) is the key enzyme connecting oxidative phosphorylation (OXPHOS) and glycolysis as well as a target of the antidiabetic drug metformin (MF) in the liver. There are no data on the expression and role of mGPDH as a metformin target in cancer. In this study, we evaluated mGPDH as a potential target of metformin in thyroid cancer and investigated its contribution in thyroid cancer metabolism. Read More

    MicroRNA-125b Affects Vascular Smooth Muscle Cell Function by Targeting Serum Response Factor.
    Cell Physiol Biochem 2018 Apr 19;46(4):1566-1580. Epub 2018 Apr 19.
    Division of Vascular Surgery, Guangdong Engineering Laboratory for Diagnosis and Treatment of Vascular Disease, Guangzhou, China.
    Background/aims: Increasing evidence links microRNAs to the pathogenesis of peripheral vascular disease. We recently found microRNA-125b (miR-125b) to be one of the most significantly down‑regulated microRNAs in human arteries with arteriosclerosis obliterans (ASO) of the lower extremities. However, its function in the process of ASO remains unclear. Read More

    Endocr Pract 2018 Apr 24. Epub 2018 Apr 24.
    From the 1College of Physicians & Surgeons, Columbia University, New York, New York.
    Objective: Iodine is a required nutrient for thyroid function. The mountainous terrain in the Republic of Artsakh (Nagorno Karabakh) in the south Caucasus suggests that it is likely to be endogenously deficient in iodine. The region is heavily dependent on neighboring Armenia for food imports including iodized salt. Read More

    Endocr Pract 2018 Apr 24. Epub 2018 Apr 24.
    School of Health Policy and Management, Institute of Medicine of Chung Shan Medical University.
    Objective: Over the past three decades, few studies on hyperthyroidism treatment trends have been reported. Therefore, we used a nationwide population-based database to evaluate the current practices and management of hyperthyroidism in Taiwan.

    Methods: This retrospective study included a random selection of 1 million people in Taiwan between 2004 and 2010. Read More

    mRECIST criteria to assess recurrent thyroid carcinoma treatment response after radiofrequency ablation: a prospective study.
    J Endocrinol Invest 2018 Apr 23. Epub 2018 Apr 23.
    Diagnostic and Interventional Radiology, Department of Translational Research and New Technologies in Medicine, University of Pisa, Via Paradisa, 2, Cisanello Hospital, 56100, Pisa, Italy.
    Purpose: Surgical removal is recommended for recurrent thyroid carcinomas (RTCs) unable to uptake radioiodine and/or not responsive to chemotherapy. However, repeated neck dissection is difficult for surgeons. Thus, radiofrequency ablation (RFA) was proposed for RTCs. Read More

    Primary thyroid MALToma- a rare diagnosis of an unassuming thyroid nodule.
    J Community Hosp Intern Med Perspect 2018 6;8(1):42-45. Epub 2018 Feb 6.
    Department of Internal Medicine, Reading Health System, PA, USA.
    Primary thyroid lymphoma, although a rare malignancy, can arise in common chronic inflammatory conditions such as Hashimoto's thyroiditis. Incidental finding of a thyroid nodule with chronic thyroid inflammation warrants further investigation. Early detection of malignancy can play a vital role in improved outcomes. Read More

    Angiotensin-(1-7) reduces cardiac effects of thyroid hormone by GSK3Β/NFATc3 signaling pathway.
    Clin Sci (Lond) 2018 Apr 23. Epub 2018 Apr 23.
    Department of Anatomy, University of Sao Paulo, Av Prof. Lineu Prestes, 2415, Cidade Universitária - Butantã, São Paulo, 05508-000, Brazil
    Patients with hyperthyroidism exhibit increased risk of development and progression of cardiac diseases. The activation of the Renin Angiotensin System (RAS) has been indirectly implicated in these cardiac effects observed in hyperthyroidism. Angiotensin-(1-7) (Ang-(1-7)) has previously been shown to counterbalance pathological effects of Angiotensin II (Ang II). Read More

    Hypoparathyroidism in Total Thyroidectomy due to Benign Thyroid Diseases.
    Clin Ther 2018 Apr 20. Epub 2018 Apr 20.
    Bezmialem Vakif University, Faculty of Medicine, Department of Otorhinolaryngology, Istanbul, Turkey.
    Purpose: Our aim was to compare the effects of exposing the recurrent laryngeal nerve throughout its entire course with exposing the nerve only at its entry to the larynx in patients undergoing total thyroidectomy due to benign thyroid diseases, and to evaluate the effects of these methods on the risk for hypoparathyroidism.

    Methods: The medical records of 437 patients who had undergone total thyroidectomy at the ear, nose, and throat clinic between 2001 and 2015 for benign thyroid diseases were evaluated retrospectively. Mean patient age was 46. Read More

    [Dysphagia from a gastroenterologist's perspective].
    Dtsch Med Wochenschr 2018 May 23;143(9):660-671. Epub 2018 Apr 23.
    Swallowing disorders (dysphagia) comprise a common cause of medical consultation and are defined as a subjective sensation of difficulty or abnormality of swallowing. In the initial step, a clear differentiation of dysphagia from odynophagia and globus sensation for further diagnostic procedures is mandatory. The careful questioning of patients symptoms and complaints is often helpful for the differentiation of oropharyngeal and esophageal dysphagia. Read More

    Image-guided chemical and thermal ablations for thyroid disease: Review of efficacy and complications.
    Head Neck 2018 Apr 23. Epub 2018 Apr 23.
    Coordinator of The International Head and Neck Scientific Group.
    Image-guided ablation of thyroid disease is increasingly being commonly reported. Techniques including ethanol injection and thermal ablation using radio-frequency, laser, and microwave devices have been described. Minimally invasive approaches to the management of benign cystic, solid, and functional thyroid nodules as well as both primary and recurrent thyroid malignancy have been reported. Read More

    Low thyroid function is not associated with an accelerated deterioration in renal function.
    Nephrol Dial Transplant 2018 Apr 18. Epub 2018 Apr 18.
    Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands.
    Background: Chronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the effect of thyroid hormone alterations on renal function in cross-sectional and longitudinal analyses in individuals from all adult age groups. Read More

    ACOG Committee Opinion No. 736: Optimizing Postpartum Care.
    • Authors:
    Obstet Gynecol 2018 May;131(5):e140-e150
    The weeks following birth are a critical period for a woman and her infant, setting the stage for long-term health and well-being. To optimize the health of women and infants, postpartum care should become an ongoing process, rather than a single encounter, with services and support tailored to each woman's individual needs. It is recommended that all women have contact with their obstetrician-gynecologists or other obstetric care providers within the first 3 weeks postpartum. Read More

    ACOG Committee Opinion No. 736 Summary: Optimizing Postpartum Care.
    • Authors:
    Obstet Gynecol 2018 May;131(5):949-951
    The weeks following birth are a critical period for a woman and her infant, setting the stage for long-term health and well-being. To optimize the health of women and infants, postpartum care should become an ongoing process, rather than a single encounter, with services and support tailored to each woman's individual needs. It is recommended that all women have contact with their obstetrician-gynecologists or other obstetric care providers within the first 3 weeks postpartum. Read More

    Subclinical hypothyroidism is associated with migraine: A case-control study.
    Cephalalgia 2018 Jan 1:333102418769917. Epub 2018 Jan 1.
    2 Endocrinology, Diabetes and Metabolic Disease Unit, A.O. Ordine Mauriziano di Torino, Torino, Italy.
    Background Recent studies suggested a potential association between both overt and subclinical hypothyroidism and migraine. Aims of this study were to estimate the comorbidity of migraine in patients with subclinical hypothyroidism and to evaluate associated clinical characteristics. Methods Using a case-control strategy, 151 consecutive subclinical hypothyroidism patients (mean age 48. Read More

    Follicular Thyroid Carcinoma in a Country of Endemic Iodine Deficiency (1994-2013).
    J Thyroid Res 2018 25;2018:6516035. Epub 2018 Feb 25.
    Department of Pathology, Korle-Bu Teaching Hospital, P.O. Box 77, Korle-Bu, Accra, Ghana.
    Background: Follicular thyroid cancer (FTC) has historically been linked to iodine deficiency. Although Ghana is among the iodine deficient regions of the world, the proportions, trends, and the clinical features of FTCs have not been studied as a single disease entity. The aim of this study was to determine the relative frequencies, trends, and the clinicopathological characteristics of FTCs among all thyroid malignancies in our institution. Read More

    Autosomal dominant polycystic kidney disease: a potential mistake in the interpretation of radioiodine whole-body scintigraphy.
    Radiol Case Rep 2018 Apr 7;13(2):453-455. Epub 2018 Mar 7.
    Nuclear Medicine and Molecular Imaging Research Center, Namazi Teaching Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
    There are a few case reports of renal cysts demonstrating radioiodine uptake on scintigraphy. In this case, we report a 49-year-old man who had undergone total thyroidectomy and had been treated with radioiodine. After conventional levothyroxine withdrawal, the patient underwent thyroid remnant ablation by oral administration of 125 mci I. Read More

    Prognostic value of the 8 edition of the tumor-node-metastasis classification for patients with papillary thyroid carcinoma: a single-institution study at a high-volume center in Japan.
    Endocr J 2018 Apr 20. Epub 2018 Apr 20.
    Department of Surgery, Kuma Hospital, Kobe 650-0011, Japan.
    The tumor-node-metastasis (TNM) staging system is most commonly adopted to evaluate the prognosis of patients with thyroid carcinoma. The 8 edition of the TNM staging system, an extensively revised version of the 7 edition, was recently released. We aimed to investigate whether and how well the 8 edition reflects the cause-specific survival (CSS) of patients with papillary thyroid carcinoma by analyzing the cases in 5,892 patients who underwent initial surgery at Kuma Hospital between 1987 and 2005. Read More

    Cancer incidence and mortality patterns in Luwan district of Shanghai during 2002-2011.
    Drug Discov Ther 2018 Apr 22. Epub 2018 Apr 22.
    Office of Clinical Epidemiology, Obstetrics and Gynecology Hospital of Fudan University.
    Cancer has become the leading cause of death and a major burden to public health in China. The current study analyzed the composition, incidence, mortality, and temporal trends for some major cancer types among permanent residents in Luwan district of Shanghai from 2002 to 2011, so as to provide data for cancer research. Data were collected from the database of cancer registration and management system in Shanghai. Read More

    Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians.
    Genomics 2018 Apr 18. Epub 2018 Apr 18.
    Department of Medical Biology, University of Split, School of Medicine, Šoltanska 2, Split, Croatia. Electronic address:
    Autoimmune thyroid diseases (AITD) are multifactorial endocrine diseases most frequently accompanied by Tg and TPO autoantibodies. Both antibodies have a higher prevalence in females and act under a strong genetic influence. To identify novel variants underlying thyroid antibody levels, we performed GWAS meta-analysis on the plasma levels of TgAb and TPOAb in three Croatian cohorts, as well as gender specific GWAS and a bivariate analysis. Read More

    Internalization of G-protein-coupled receptors: Implication in receptor function, physiology and diseases.
    Best Pract Res Clin Endocrinol Metab 2018 Apr 6;32(2):83-91. Epub 2018 Feb 6.
    Institute of Pharmacology and Toxicology and Bio-Imaging Center, University of Würzburg, Würzburg, Germany; Institute for Molecular Cell Biology, CMB-Center for Molecular Biomedicine, University Hospital Jena, Friedrich Schiller University Jena, Jena, Germany.
    G protein-coupled receptors (GPCRs) are the largest family of membrane receptors and mediate the effects of numerous hormones and neurotransmitters. The nearly 1000 GPCRs encoded by the human genome regulate virtually all physiological functions and are implicated in the pathogenesis of prevalent human diseases such as thyroid disorders, hypertension or Parkinson's disease. As a result, 30-50% of all currently prescribed drugs are targeting these receptors. Read More

    Physiological and Genetic Adaptations to Diving in Sea Nomads.
    Cell 2018 Apr;173(3):569-580.e15
    Centre for GeoGenetics, University of Copenhagen, Copenhagen 1350, Denmark; Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK; Wellcome Trust, Sanger Institute, Hinxton CB10 1SA, UK. Electronic address:
    Understanding the physiology and genetics of human hypoxia tolerance has important medical implications, but this phenomenon has thus far only been investigated in high-altitude human populations. Another system, yet to be explored, is humans who engage in breath-hold diving. The indigenous Bajau people ("Sea Nomads") of Southeast Asia live a subsistence lifestyle based on breath-hold diving and are renowned for their extraordinary breath-holding abilities. Read More

    Histopathological pattern of thyroid diseases in Zaria: A 10-year review.
    Niger Postgrad Med J 2018 Jan-Mar;25(1):37-42
    Department of Pathology, Ahmadu Bello University Teaching Hospital, Zaria, Kaduna State, Nigeria.
    Context: Majority of the previous studies on thyroid diseases in Northern Nigeria focussed mainly on neoplastic lesions. The non-neoplastic lesions are more common and constitute more public health burdens.

    Aim: To determine the histopathological pattern of thyroid diseases in our region and compare our findings with similar studies in Nigeria and elsewhere. Read More

    PTX3: A Potential Biomarker in Thyroid Associated Ophthalmopathy.
    Biomed Res Int 2018 20;2018:5961974. Epub 2018 Feb 20.
    Department of Ophthalmology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
    Background: Thyroid associated ophthalmopathy (TAO) is an autoimmune disease, which involves inflammation and tissue remodeling. Pentraxin-3 (PTX3) is a component of innate immune system and recently implicated in autoimmunity. This observation may indicate that PTX3 participates in the inflammatory process of TAO. Read More

    Anti-Thyroid Peroxidase Reactivity Is Heightened in Pemphigus Vulgaris and Is Driven by Human Leukocyte Antigen Status and the Absence of Desmoglein Reactivity.
    Front Immunol 2018 5;9:625. Epub 2018 Apr 5.
    Department of Dermatology, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, United States.
    Pemphigus vulgaris (PV) belongs to an autoimmune disease cluster that includes autoimmune thyroid disease (AITD), suggesting common mechanisms driving autoimmune susceptibility. Our group has shown that PV patients exhibit significant reactivity to AITD-related anti-thyroid peroxidase (anti-TPO), and anti-TPO antibodies affect signaling pathways in keratinocytes similar to anti-desmoglein (Dsg) 3 antibodies. To further assess the relevance of anti-TPO reactivity in PV, we analyzed anti-TPO levels in 280 PV and 167 healthy control serum samples across a comprehensive set of variable and static parameters of disease activity and etiopathogenesis. Read More

    Association Between Thyroid Hormones, Thyroid Antibodies, and Cardiometabolic Factors in Non-Obese Individuals With Normal Thyroid Function.
    Front Endocrinol (Lausanne) 2018 5;9:130. Epub 2018 Apr 5.
    Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.
    Background: Hypothyroidism is an important risk factor for cardiovascular diseases, and autoimmune thyroiditis (AIT) is the leading cause of hypothyroidism. Recent studies showed that even AIT patients with euthyroidism still had an increased number of early atherosclerotic lesions. However, the precise mechanism is not yet known. Read More

    Diminished ovarian reserve in patients with psoriasis.
    Taiwan J Obstet Gynecol 2018 Apr;57(2):227-230
    Ufuk University, Faculty of Arts and Sciences, Department of Statistics Ankara, Turkey.
    Objective: Psoriasis is a multi-systemic chronic inflammatory skin disease. Previous data suggests that women with some chronic inflammatory diseases have diminished ovarian reserve. This study explores ovarian reserve in patients with psoriasis. Read More

    Subclinical hypothyroidism and metabolic risk factors association: A health examination-based study in northern Taiwan.
    Biomed J 2018 Feb 30;41(1):52-58. Epub 2018 Mar 30.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.
    Background: Subclinical hypothyroidism (SCH) is defined as elevation in serum thyroid-stimulating hormone (TSH) levels despite normal serum levels of free thyroxine. It remains controversial whether people with SCH have higher total cholesterol and low-density lipoprotein cholesterol levels compared to normal-thyroid subjects. The aim of this study was to assess the metabolic risk factors for SCH. Read More

    Thyroid Hormones and Cardiovascular Function and Diseases.
    J Am Coll Cardiol 2018 Apr;71(16):1781-1796
    Clinical Physiology Institute, Consiglio Nazionale dele Ricerche (CNR), Pisa, Italy.
    Thyroid hormone (TH) receptors are present in the myocardium and vascular tissue, and minor alterations in TH concentration can affect cardiovascular (CV) physiology. The potential mechanisms that link CV disease with thyroid dysfunction are endothelial dysfunction, changes in blood pressure, myocardial systolic and diastolic dysfunction, and dyslipidemia. In addition, cardiac disease itself may lead to alterations in TH concentrations (notably, low triiodothyronine syndrome) that are associated with higher morbidity and mortality. Read More

    Exploring potential biomarkers associated with health-related quality of life in patients with coronary artery disease and heart failure.
    Eur J Cardiovasc Nurs 2018 Apr 1:1474515118772828. Epub 2018 Apr 1.
    1 Laboratory of Behavioral Medicine, Neuroscience Institute, Lithuanian University of Health Sciences, Palanga, Lithuania.
    Objective: There has been a lack of research examining associations between biomarkers and health-related quality of life (HRQoL) in patients with coronary artery disease and heart failure. In patients with coronary artery disease and heart failure, we aimed to explore potential associations between biomarkers of health such as serum levels of thyroid hormones, N-terminal pro-B-type natriuretic peptide (NT-pro-BNP), inflammatory biomarkers and HRQoL.

    Methods: In sum, 482 patients (75% male; mean age 58±10 years) with coronary artery disease and heart failure were evaluated for socio-demographic and clinical coronary artery disease risk factors. Read More

    Dynamic risk stratification system in post-lobectomy low-risk and intermediate-risk papillary thyroid carcinoma patients.
    Clin Endocrinol (Oxf) 2018 Apr 19. Epub 2018 Apr 19.
    Department of Surgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine,20 Ilsan-ro, Wonju, Gangwon-do,, 26426, Korea.
    Objective: The dynamic risk stratification (DRS) and its current definition of each response-to-therapy category in post-lobectomy papillary thyroid carcinoma (PTC) patients have not been well studied. This study aimed to validate the DRS system and to investigate useful thyroglobulin (Tg) or anti-Tg antibody (Ab)-related parameters in defining each response-to-therapy category DESIGN: Retrospective observational study.

    Patients: This historical cohort study included 619 patients with PTC treated by thyroid lobectomy. Read More

    Young Age Is Associated With Increased Rates of Residual & Recurrent Pediatric Differentiated Thyroid Carcinoma.
    Clin Endocrinol (Oxf) 2018 Apr 19. Epub 2018 Apr 19.
    Division of Endocrinology, The Hospital for Sick Children, Toronto, Ontario, Canada.
    Objective: Differentiated thyroid carcinoma is rare in young children. There are conflicting data as to whether disease in this age group differs from that in adolescents and specifically, if it is more aggressive. Current practice guidelines do not differentiate treatment between these groups, but speculate that differences may exist. Read More

    An Analysis of The American Joint Committee on Cancer 8th Edition T Staging System for Papillary Thyroid Carcinoma.
    J Clin Endocrinol Metab 2018 Apr 16. Epub 2018 Apr 16.
    Department of Head and Neck Surgery, Liverpool Hospital, NSW, Australia.
    Background: The American Joint Committee on Cancer (AJCC) removed microscopic extrathyroidal extension (m-ETE) from the 8th edition T staging for papillary thyroid carcinoma (PTC) based on increasing evidence that it is not an independent prognostic factor.

    Objectives: We aimed to compare the prognostic performance of AJCC 7th (pT7) and 8th (pT8) edition T stage systems, particularly in patient's ≥55 years old without macroscopic ETE or distant metastases, in whom T classification impacts TNM stage.

    Method: A retrospective analysis of disease-free survival (DFS) in 577 patients with PTC comparing pT8 versus pT7 using the Akaike information criterion (AIC), Harrell's C-index and Proportion of Variation Explained (PVE). Read More

    Tumor development in Japanese patients with Lynch syndrome.
    PLoS One 2018 19;13(4):e0195572. Epub 2018 Apr 19.
    Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
    Background: Lynch syndrome (LS) patients have a high risk of developing various tumors. This study aimed to clarify the characteristics of tumors developing in LS patients.

    Methods: This is a retrospective review of 55 LS patients treated at Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital. Read More

    Transconjunctival Triamcinolone Injection for Upper Lid Retraction in Thyroid Eye Disease-A New Injection Method.
    Ophthal Plast Reconstr Surg 2018 Apr 17. Epub 2018 Apr 17.
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Purpose: To evaluate the role of transconjunctival triamcinolone acetonide (TA) injection in the management of upper eyelid retraction in thyroid eye disease.

    Methods: Retrospective interventional review of all patients who underwent transconjunctival TA injection (40 mg/mL) for thyroid eye disease-related upper eyelid retraction from January 2010 to December 2016 in a single tertiary institution. The present study comprised 2 groups: Patients receiving only TA injection (group 1), and patients receiving both TA injection and other immunosuppressive therapy (group 2). Read More

    Insulin resistance is associated with larger thyroid volume in adults with type 1 diabetes independently from presence of thyroid autoimmunity.
    Scand J Clin Lab Invest 2018 Apr 19:1-6. Epub 2018 Apr 19.
    a Department of Internal Medicine and Diabetology , Poznan University of Medical Sciences , Poznan , Poland.
    To investigate the effect of insulin resistance (IR) on thyroid function, thyroid autoimmunity (AIT) and thyroid volume in type 1 diabetes (T1DM). 100 consecutive patients with T1DM aged 29 (±6) years with diabetes duration 13 (±6) years were included. Exclusion criteria were: history of thyroid disease, current treatment with L-thyroxin or anti-thyroid drugs. Read More

    Measurement properties of ThyPRO short-form (ThyPRO-39) for use in Chinese patients with benign thyroid diseases.
    Qual Life Res 2018 Apr 18. Epub 2018 Apr 18.
    Department of Surgery, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong SAR, China.
    Purpose: To evaluate the validity and reliability of a newly-translated Thyroid-specific Patient-Reported Outcome short-form (ThyPRO-39) instrument for ethnic-Chinese patients suffering from benign thyroid diseases.

    Methods: The translation and cross-cultural adaptation of the English ThyPRO-39 were performed using the double forward translation, reconciliation, single backward translation, and cognitive debriefing, followed by a panel review. Cross-sectional data of 308 patients with benign thyroid diseases were utilized for this psychometric evaluation of ThyPRO-39 instrument. Read More

    Exposure to Maternal Diabetes Is Associated With Early Abnormal Vascular Structure in Offspring.
    Front Physiol 2018 4;9:350. Epub 2018 Apr 4.
    UMR Centre National de la Recherche Scientifique 6015, INSERM U1083, MITOVASC, University of Angers, Angers, France.
    exposure to maternal diabetes increases the risk of developing hypertension and cardiovascular disorders during adulthood. We have previously shown that this is associated with changes in vascular tone in favor of a vasoconstrictor profile, which is involved in the development of hypertension. This excessive constrictor tone has also a strong impact on vascular structure. Read More

    Investigation on Aetiological Factors in Patients with Hyperhidrosis.
    Cutan Ocul Toxicol 2018 Apr 18:1-17. Epub 2018 Apr 18.
    a Department of Dermatology , Ministry of Health Atatürk Training and Research Hospital , Ankara , Turkey.
    Background: Hyperhidrosis is a condition where the amount of sweat released to skin surface increases due to the over-active eccrine sweat glands. Hyperhidrosis causes considerable psychosocial distress in affected people. It affects the quality of life and leads to social anxiety disorders. Read More

    Asymptomatic intrathyroidal pyriform sinus fistula mimicking thyroid cancer: A case report and literature review.
    Medicine (Baltimore) 2018 Apr;97(16):e0488
    Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Republic of Korea.
    Rationale: There have been many reports of non-thyroidal lesions which can be mistaken for thyroidal lesions on ultrasound (US) examination. However, it is not known that pyriform sinus fistula (PSF) can manifest as an incidental thyroid nodule and cause serious complication on fine-needle aspiration (FNA).

    Patient Concerns: We present a 34-year-old man with PSF incidentally detected on US. Read More

    The effects of celecoxib on the proliferation and ultrastructural changes of MDA-MB-231 breast cancer cells.
    Ultrastruct Pathol 2018 Apr 18:1-6. Epub 2018 Apr 18.
    a Department of Breast and Thyroid Surgery, Zhongnan Hospital, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center , Wuhan University , Wuhan , China.
    This study sought to investigate the effects of celecoxib on the proliferation and morphological changes of triple-negative breast cancer (TNBC) MDA-MB-231 cells. In this study, after MDA-MB-231 cells were treated with a certain concentration of celecoxib, a cell counting kit-8 (CCK-8) proliferation assay was used to detect cell viability. Western blotting was utilized to analyze the expression level of caspase-3, which is an apoptosis-related protein. Read More

    Induction of disease remission with one cycle of alemtuzumab in relapsing-remitting MS.
    J Neurol 2018 Apr 17. Epub 2018 Apr 17.
    Division of Neurology, New York-Presbyterian/Weill Cornell Medicine, 1305 York Avenue, Suite Y-217, New York, NY, 10021, USA.
    Objective: To investigate a single-course treatment with alemtuzumab in patients with relapsing-remitting multiple sclerosis.

    Methods: We performed a retrospective chart review of all patients diagnosed with RRMS who were treated with alemtuzumab at our MS center and who had at least 12 month follow-up since the first dose. Data on radiological and clinical relapse were collected for the 2 years prior to patients' first dose of alemtuzumab and were tracked until the time of analysis. Read More

    Carney complex: a case with thyroid follicular adenoma without a PRKAR1A mutation.
    Surg Case Rep 2018 Apr 17;4(1):34. Epub 2018 Apr 17.
    Department of Digestive and General Surgery, Faculty of Medicine, Shimane University, 89-1 Enya, Izumo, Shimane, 693-8501, Japan.
    Background: Carney complex (CNC) is a very rare disease. Although thyroid lesions are included in the diagnostic criteria for CNC, they are an infrequent occurrence.

    Case Presentation: The patient was a 69-year-old woman who had undergone the removal of a left atrial myxoma 10 years earlier, at the age of 59. Read More

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