The Role of Pregnancy, Perinatal Factors, and Hormones in Maternal Cancer Risk: A review of the evidence.
- Rebecca Troisi,
- Tone Bjørge,
- Mika Gissler,
- Tom Grotmol,
- Cari M Kitahara,
- Solbjørg Makalani Myrtveit Saether,
- Anne Gulbech Ording,
- Camilla Sköld,
- Henrik Toft Sørensen,
- Britton Trabert,
- Ingrid Glimelius
J Intern Med 2018 Feb 24. Epub 2018 Feb 24.
Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
An understanding of the origin of cancer is critical for cancer prevention and treatment. Complex biological mechanisms promote carcinogenesis, and there is increasing evidence that pregnancy-related exposures influence fetal growth cell division and organ functioning and may have a long-lasting impact on health and disease susceptibility in the mothers and offspring. Nulliparity is an established risk factor for breast, ovarian, endometrial, and possibly pancreatic cancer, while the risk of kidney cancer is elevated in parous compared with nulliparous women. Read More