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    History of thyroid disease and survival of ovarian cancer patients: results from the Ovarian Cancer Association Consortium, a brief report.
    Br J Cancer 2017 Aug 17. Epub 2017 Aug 17.
    Deparment of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.
    Background: Findings from in vitro studies suggest that increased exposure to thyroid hormones can influence progression of ovarian tumours. However, epidemiologic evidence on this topic is limited.

    Methods: We pooled data from 11 studies from the Ovarian Cancer Association Consortium. Read More

    Using k-dependence causal forest to mine the most significant dependency relationships among clinical variables for thyroid disease diagnosis.
    PLoS One 2017 17;12(8):e0182070. Epub 2017 Aug 17.
    Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, ChangChun City 130012, China.
    Numerous data mining models have been proposed to construct computer-aided medical expert systems. Bayesian network classifiers (BNCs) are more distinct and understandable than other models. To graphically describe the dependency relationships among clinical variables for thyroid disease diagnosis and ensure the rationality of the diagnosis results, the proposed k-dependence causal forest (KCF) model generates a series of submodels in the framework of maximum spanning tree (MST) and demonstrates stronger dependence representation. Read More

    Cabozantinib As Salvage Therapy for Patients With Tyrosine Kinase Inhibitor-Refractory Differentiated Thyroid Cancer: Results of a Multicenter Phase II International Thyroid Oncology Group Trial.
    J Clin Oncol 2017 Aug 17:JCO2017730226. Epub 2017 Aug 17.
    Maria E. Cabanillas and Komal Shah, The University of Texas MD Anderson Cancer Center, Houston, TX; Jonas A. de Souza, University of Chicago Medical Center, Chicago, IL; Susan Geyer, University of South Florida, Tampa; Michael E. Menefee, Mayo Clinic Jacksonville, Jacksonville, FL; Lori J. Wirth, Massachusetts General Hospital, Boston, MA; Stephen V. Liu, MedStar Georgetown University Hospital; John Wright, National Cancer Institute, Washington, DC; and Manisha H. Shah, Ohio State University, Columbus, OH.
    Purpose Sorafenib and lenvatinib are oral multikinase inhibitors targeting vascular endothelial growth factor receptor (VEGFR) and approved for radioiodine (RAI)-refractory differentiated thyroid cancer (DTC). However, there are no approved second- or third-line therapies. MET is implicated in resistance to VEGFR inhibitors. Read More

    Endocr Pract 2017 Aug 17. Epub 2017 Aug 17.
    Endocrinology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill-Cornell College of Medicine, New York, NY.
    Abstracts: Objective : Given the increase in the incidence of thyroid cancer in the United States, and it's potential public health implications, patient studies assessing ethnic, disparity and health care access are important. In this study, we retrospectively examined the variability in stage of thyroid cancer at presentation and final outcome among Hispanic vs non-Hispanic patients.

    Method: After obtaining IRB approval, we retrospectively reviewed the medical records of 220 adult patients with papillary thyroid carcinoma(PTC) who were treated at UT Health Science Center San Antonio between1996 and 2013. Read More

    Endocr Pract 2017 Aug 17. Epub 2017 Aug 17.
    From: 1Section of Endocrine Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA 90095.
    Objective: There has been increasing interest in active surveillance of papillary thyroid microcarcinoma (mPTC). The objective of this study was to characterize the incidence and outcomes of non-operatively managed differentiated thyroid cancers (DTCs) in California.

    Methods: Biopsy-proven DTCs from the California Cancer Registry (CCR) were linked to data from the California Office of Statewide Health Planning and Development (2004-2012). Read More

    Endocr Pract 2017 Aug 17. Epub 2017 Aug 17.
    Rheumatology Department, Federal University of Uberlândia, Brazil.
    Objectives: Because routine investigations are necessary for the early detection of thyroid disease, this study aimed to assess the prevalence of autoimmune thyroid disease (ATD) and thyroid dysfunction (TD) in patients with systemic lupus erythematosus (SLE).

    Methods: Seventy-nine SLE patients (American College of Rheumatology criteria) and 159 control patients with no diagnosis of autoimmune diseases (except for ATD) were consecutively evaluated regarding changes in laboratory assessments of thyroid function and the presence of ATD.

    Results: ATD was detected in 11. Read More

    The role of radiopharmaceuticals in Amiodarone-induced thyroid pathology.
    Curr Radiopharm 2017 Aug 16. Epub 2017 Aug 16.
    Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca. Romania.
    Amiodarone is a di-iodinated benzofuran derivative and is classified as a class III antiarrhythmic agent. It is one of the most powerful and effective antiarrhythmics, being a first-line agent due to its ability to treat ventricular and supraventricular dysrhythmias; since 1960 the drug has become one of the most frequently prescribed antiarrhythmics, despite its potentially serious, side effects. By far, one of the most challenging condition is the thyroid pathology induced by this drug. Read More

    A phase 3, multicenter, double-blind, placebo-controlled trial of lenvatinib (E7080) in patients with (131)I-refractory differentiated thyroid cancer (SELECT).
    J Clin Oncol 2014 Jun;32(18_suppl):LBA6008
    Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
    LBA6008 Background: Lenvatinib (LEN) is an oral tyrosine kinase inhibitor of the VEGFR1-3, FGFR1-4, PDGFRβ, RET, and KIT signaling networks. Based on efficacy results of the phase 2 study of patients (pts) with (131)I-refractory differentiated thyroid cancer (RR-DTC), this phase 3 Study of (E7080) Lenvatinib in Differentiated Cancer of the Thyroid (SELECT) was developed.

    Methods: This randomized, double-blind, placebo (PBO)-controlled study enrolled pts with RR-DTC with documented disease progression within 13 months (mo). Read More

    Process outcome measures of patients with head/neck, thoracic, and gynecologic malignancies in the MDC clinic.
    J Clin Oncol 2014 Oct;32(30_suppl):61
    The University of Manoa Honors Program-School of Nursing, Honolulu, HI.
    61 Background: Queen's Medical Center (QMC) was selected as one of 14 sites nationwide to participate in the expansion of the National Cancer Institute's Community Cancer Centers program in 2010. In 2011, QMC implemented Multidisciplinary Clinics (MDC) to make the treatment of patients with head and neck (H&N), thyroid, thoracic, and GYN malignancies more efficient and seamless. The purpose of this study was to examine the following process outcomes: timeliness of care, adherence to MDC treatment plans and national guidelines, and utilization of ancillary services in H&N, thyroid, thoracic, and GYN MDC. Read More

    Secondary nonbreast malignancies (SNBM) after primary breast cancer (BC).
    J Clin Oncol 2014 Sep;32(26_suppl):112
    McKesson Specialty Health/US Oncology, Houston, TX.
    112 Background: BC survivors are at higher risk of developing SNBM due to treatment effects and shared behavioral and genetic factors. Associations between histologic subtypes of primary BC and secondary endometrial or ovarian cancer have been reported. Less is known about subtype-specific associations with other secondary solid tumors. Read More

    The accuracy of preoperative U.S.-guided vacuum-assisted breast biopsy (VABB) in determining ER, PgR, HER2, and Ki67 status in early breast cancer.
    J Clin Oncol 2013 Sep;31(26_suppl):37
    Department of Breast and Endocrine Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
    37 Background: The intrinsic subtypes are important in the management of patients with early breast carcinoma; however, there have been only a few reports about the accuracy of preoperative subtyping by the preoperative ultrasonography guided vacuum-assisted breast biopsy (U.S.-guided VABB). Read More

    Sorafenib in locally advanced or metastatic patients with radioactive iodine-refractory differentiated thyroid cancer: The phase III DECISION trial.
    J Clin Oncol 2013 Jun;31(18_suppl)
    Institut Gustave Roussy, Villejuif, France.
    4 Background: Sorafenib, an orally active inhibitor of VEGFR1-3 and Raf kinases, has shown promising clinical activity in single-arm phase II studies in radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC). The double-blind, randomized, multicenter phase III DECISION trial examined sorafenib efficacy and safety vs placebo in patients with progressive RAI-refractory DTC.

    Methods: Patients with locally advanced/metastatic RAI-refractory DTC who progressed in the preceding 14 months were randomized 1:1 to sorafenib 400 mg bid po or placebo. Read More

    Unusual Manifestation of Anaplastic Thyroid Cancer.
    Acta Medica (Hradec Kralove) 2008 ;51(4):233-236
    Charles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, The Fingerland Department of Pathology, Hradec Králové, Czech Republic.
    Introduction: The authors present a rare case of a patient with symptoms consistent with retropharyngeal abscess. The diagnosis of anaplastic thyroid cancer was made after surgery and subsequent histological examination.

    Case Report: An 80-year-old woman was referred to Dpt. Read More

    Impact of eribulin on overall survival in patients with metastatic breast cancer with visceral disease.
    J Clin Oncol 2011 Sep;29(27_suppl):239
    Weill Cornell Medical College, New York, NY; Vall d'Hebron University Hospital, Barcelona, Spain; University of Leeds and St. James's University Hospital, Leeds, United Kingdom; Eisai, Hatfield, United Kingdom; Eisai Inc., Woodcliff Lake, NJ; Baylor Sammons Cancer Center, Texas Oncology, US Oncology, Dallas, TX.
    239 Background: Visceral disease is associated with poor survival outcome in women with metastatic breast cancer (mBC). Eribulin mesylate is a nontaxane microtubule dynamics inhibitor indicated for 3rd-line monotherapy in patients (pts) with mBC previously treated with at least two chemotherapeutic regimens in the metastatic setting, including an anthracycline and a taxane.

    Methods: Evidence from the global, randomized, multicenter, phase III clinical trial of eribulin in mBC (EMBRACE) demonstrated improved overall survival (OS) for eribulin-treated pts when compared to treatment of physician's choice (TPC). Read More

    A case of concurrent silent sinus syndrome, thyroid eye disease, idiopathic orbital inflammatory syndrome, and dacryoadenitis.
    Orbit 2017 Aug 16:1-3. Epub 2017 Aug 16.
    c Oculoplastic and Orbital Surgery Service , Wills Eye Hospital , Philadelphia , Pennsylvania , USA.
    This is a retrospective case description of a single female patient found to have concomitant bilateral silent sinus syndrome, bilateral thyroid eye disease, unilateral dacryoadenitis, and idiopathic orbital inflammation that presented as progressive unilateral right-sided proptosis. The spectrum of inflammatory orbital diseases can make discerning between different entities challenging, but more unique in this case was the simultaneous presentation with bilateral silent sinus syndrome, a rare entity in its own right. Identifying each of these concurrent disease processes is important to establishing a multidisciplinary treatment approach to address all the patient's orbital and peri-orbital pathology. Read More

    Occurence of autoantibodies in healthy Omani individuals.
    J Sci Res Med Sci 2001 Apr;3(1):13-19
    Department of Microbiology & Immunology, College of Medicine, Sultan Qaboos University, P.O. Box 35, Al-Khod 123, Muscat, Sultanate of Oman.
    Objectives: To investigate the occurence of various autoantibodies in the Omani population.

    Method: Sera from 392 healthy Omani individuals comprising 183 pregnant women and 209 blood donors (183 men and 26 women) were investigated. Autoantibodies were detected using immunofluorescence, haemagglutination and latex agglutination techniques. Read More

    Estimation of Upper Limit of Normal for Serum Alanine Transaminase in Healthy South Indian Population.
    Indian J Clin Biochem 2017 Jul 17;32(3):337-342. Epub 2016 Sep 17.
    Department of Statistics, Loyola College, Nungambakkam, Chennai, India.
    Alanine aminotransferase (ALT) is the most common and cost effective screening test for asymptomatic liver disease. There is paucity of data on normal ALT among healthy individuals in India. An observational cross sectional study was conducted from January to July 2013 to estimate the upper limit of normal for ALT in healthy south Indian population. Read More

    Analysis of risk factors of rapid thyroidal radioiodine-131 turnover in Graves' disease patients.
    Sci Rep 2017 Aug 15;7(1):8301. Epub 2017 Aug 15.
    Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, China.
    Rapid iodine-131((131)I) turnover in the thyroid gland is an important feature of Graves' disease (GD) and also a strong predictor of radioiodine therapy failure. The aim of this study was to explore the predictors of rapid (131)I turnover. The clinical data on 2543 patients were retrospectively reviewed. Read More

    Screening of congenital hypothyroidism in preterm, low birth weight and very low birth weight neonates: A systematic review.
    Pediatr Neonatol 2017 Jul 22. Epub 2017 Jul 22.
    Students Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
    Evidence from different screening programs indicated that the rate of congenital hypothyroidism (CH) was higher in pre-term and low-birth-weight (LBW) newborns than normal ones. Incomplete development of hypothalamic-pituitary axis in this group of neonates results in the delayed rise of TSH and missing cases with CH. Hence, there is a great need for a practicable systematic screening method for proper diagnosis of CH in this group of neonates. Read More

    Newborn Thyroid Screening: Influence of Pre-Analytic Variables on Dried Blood Spot TSH Measurement.
    Thyroid 2017 Aug 16. Epub 2017 Aug 16.
    Intermountain Medical Center , 5121 S. Cottonwood Street , Murray, Utah, United States , 84107 ;
    Background: Measuring thyroid stimulating hormone (TSH) eluted from a dried blood spot (DBS) is used to screen an estimated 30 million newborns annually for congenital hypothyroidism. Newborn thyroid screening has eliminated cretinism from the industrialized world and decreased the adverse effects of unrecognized congenital hypothyroidism on neurocognitive development. Hematocrit, a pre-analytic variable that affects the measurement of TSH from a DBS, contributes to the imprecision of DBS TSH measurement and could account for false negative and false positive DBS newborn screening test results. Read More

    Models of non-Alcoholic Fatty Liver Disease and Potential Translational Value: the Effects of 3,5-L-diiodothyronine.
    Ann Hepatol 2017 Aug;16(5):707-719
    University of Genoa, Genoa, Italy Department of Earth, Environmental and Life Sciences-DISTAV.
    Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in industrialized countries and is associated with increased risk of cardiovascular, hepatic and metabolic diseases. Molecular mechanisms on the root of the disrupted lipid homeostasis in NAFLD and potential therapeutic strategies can benefit of in vivo and in vitro experimental models of fatty liver. Here, we describe the high fat diet (HFD)-fed rat in vivo model, and two in vitro models, the primary cultured rat fatty hepatocytes or the FaO rat hepatoma fatty cells, mimicking human NAFLD. Read More

    Thyroid cancer incidence in Canada: a national cancer registry analysis.
    CMAJ Open 2017 Aug;5(3):E612-E616
    Affiliations: School of Public Health (Topstad), University of Alberta, Edmonton, Alta.; Department of Family Medicine and Department of Community Health Sciences (Dickinson), University of Calgary, Calgary, Alta.
    Background: Thyroid cancer incidence rates are increasing in many developed countries while mortality rates remain stable. International evidence shows that the increase in incidence rates is mostly caused by overdiagnosis of small papillary cancers. We sought to describe how thyroid cancer incidence has changed and how it varies between provinces in Canada. Read More

    Thyroid hormone receptor-beta agonist GC-1 inhibits Met-β-catenin driven hepatocellular cancer.
    Am J Pathol 2017 Aug 11. Epub 2017 Aug 11.
    Department of Pathology and Medicine, and Pittsburgh Liver Research Center, University of Pittsburgh, School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address:
    The thyromimetic agent GC-1 induces hepatocyte proliferation via Wnt/β-catenin signaling and may promoting regeneration in both acute and chronic liver insufficiencies. However, β-catenin activation particularly due to mutations in CTNNB1 is seen in a subset of hepatocellular carcinomas (HCC). Thus, it will be critical to address any effect of GC-1 on HCC growth and development, before its use can be advocated to stimulate regeneration in chronic liver diseases. Read More

    Encapsulated follicular variant of papillary thyroid cancer: are these tumors really benign?
    J Surg Res 2017 Aug 4;216:138-142. Epub 2017 May 4.
    Department of Surgery, University of California, Irvine, California.
    Background: Recent studies suggest that the encapsulated form of follicular variant of papillary thyroid cancer (eFVPTC) behaves more similarly to benign lesions and can be treated with thyroid lobectomy alone instead of total thyroidectomy. To distinguish aggressive cancers from more benign lesions more clearly, the objective of this study was to determine if the eFVPTC behaves less aggressively than the nonencapsulated variant (neFVPTC).

    Methods: A prospectively collected endocrine surgery database in our institution was reviewed for all patients with FVPTC on surgical pathology from 1999 to 2012. Read More

    Long-term outcomes of lateral neck dissection in patients with recurrent or persistent well-differentiated thyroid cancer.
    Thyroid 2017 Aug 15. Epub 2017 Aug 15.
    Tampa General Hospital, 7829, The Clayman Thyroid Cancer Center , 1 Tampa General Circle , Tampa, Florida, United States , 33601-1289.
    Background: Well-differentiated thyroid carcinoma (WDTC) has a high predilection for regional metastatic spread; rates for WDTC lateral neck recurrence are reported to be as high as 24% in patients after initial thyroidectomy, lateral neck surgery and adjuvant radioactive iodine treatment (RAI). The objective of the study was to evaluate the efficacy, safety, and long-term outcome of comprehensive lateral neck dissection (LND) of levels II-V for recurrent or persistent WDTC in a tertiary referral center.

    Methods: We retrospectively analyzed our standardized approach of LND for recurrent WDTC in the lateral neck compartment. Read More

    Temporal changes in thyroid nodule volume: lack of effect on paranodular thyroid tissue volume.
    Thyroid 2017 Aug 15. Epub 2017 Aug 15.
    Università di Roma Sapienza, Dipartimento di Medicina Interna e Specialità Mediche, Rome, Italy ;
    Background: The term "nodular goiter" has long been used to refer to a nodular thyroid gland, based on the assumption that nodule growth may be associated with hyperplasia of the surrounding non-nodular tissue. The aim of this prospective, multicenter, observational study was to determine whether nodule growth is accompanied by growth in the non-nodular tissue.

    Methods: Eight Italian thyroid-disease referral centers enrolled 992 consecutive patients with 1-4 benign nodules. Read More

    [Comparative long-term results of surgical treatment of patients with diffuse toxic goiter].
    Khirurgiia (Mosk) 2017 (8):13-17
    Pavlov Ryazan State Medical University, Ryazan, Russia.
    Aim: To analyze long-term outcomes of Graves' disease management.

    Material And Methods: There were 428 patients for the periods 2000-2004 and 2005-2010. Patients were called for examination and thyroid status control. Read More

    Commentary: Health Concerns of Brazil Nut Consumption.
    J Altern Complement Med 2017 Aug 14. Epub 2017 Aug 14.
    Department of Internal Medicine, Naval Hospital of Crete , Chania, Greece .
    Brazil nuts are the fruit of the enormous tropical tree Bertholletia excelsa that are produced in and exported from the territory of the Amazon. As a natural rich source of selenium (Se), the consumption of Brazil nuts is often suggested as therapeutic among patients with autoimmune thyroid diseases. In this review, the current knowledge regarding the main health concerns of Brazil nut consumption, such as Se toxicity, Se-induced type 2 diabetes mellitus, weight gain, radioactivity, aflatoxins, and allergic reactions, is presented and discussed. Read More

    AL amyloidosis, hypothyroidism and reduced tissue availability of thyroid hormones by thyroid hormone-binding immunoglobulin: a new possible perspective.
    J Intern Med 2017 Aug 14. Epub 2017 Aug 14.
    Department of Clinical and Experimental Medicine - Dermatology, University of Messina, Messina, Italy.
    We read the interesting article by Muchtar et al. [1] on the prevalence of hypothyroidism in AL amyloidosis and its association with survival disadvantage. Particularly, hypothyroid patients had more frequent renal and hepatic involvement by amyloidosis, and a higher light chain burden than euthyroid patients. Read More

    Clinical Implications of Immunoglobulin G4 to Graves' Ophthalmopathy.
    Thyroid 2017 Aug 12. Epub 2017 Aug 12.
    College of Medicine, Hallym University, Division of Endocrinology and Metabolism, Department of Internal Medicine, Chuncheon-Si, Korea, Republic of ;
    Background: This study aimed to explore relation of immunoglobulin G4 (IgG4) to clinical and laboratory characteristics of patients newly diagnosed with Graves' disease (GD) without or with Graves' ophthalmopathy (GO), and to analyze association of IgG4 with development and grade of GO in GD patients.

    Methods: Sixty-four GD patients and 64 sex- and age-matched euthyroid subjects were enrolled. Serum levels of thyroid hormones, thyroid autoantibodies, immunoglobulin G (IgG) and IgG4 were measured, and ophthalmological and ultrasonographical evaluation was performed. Read More

    Intermittent Dosing of Dabrafenib and Trametinib in Metastatic BRAFV600E Mutated Papillary Thyroid Cancer: Two Case Reports.
    Thyroid 2017 Aug 12. Epub 2017 Aug 12.
    Boston Medical Center, 1836, Section of Hematology and Oncology, Boston, Massachusetts, United States ;
    Background: A multi-institutional randomized Phase II trial of continuous dosing of dabrafenib with or without trametinib is ongoing in metastatic thyroid cancer. Preclinical evidence and emerging clinical experience in other cancers support evaluating intermittent dosing of these two agents to achieve more durable response, while being better tolerated and more cost effective.

    Patients: Two consecutive patients with symptomatic, metastatic radioactive iodine (RAI) resistant BRAF V600E mutated papillary thyroid cancer and poor performance status were treated initially with dabrafenib 150mg twice daily plus trametinib 2mg once daily, first in continuous daily dosing, then in a five-week-on and three-week-off schedule. Read More

    Personalised immunomodulating treatments for Graves' disease: fact or fiction?
    Swiss Med Wkly 2017 Aug 14;147:w14476. Epub 2017 Aug 14.
    Medical University Department, Clinic for Medical University Department, Clinic for Endocrinology, Diabetes and Metabolism, Kantonsspital Aarau, Switzerland; Medical Faculty of the University of Basel, Switzerland.
    Although Graves' disease has been recognised for more than 100 years, its physiopathological mechanisms are incompletely understood. Treatment strategies today mainly focus on suppression of thyroid hormone production by use of antithyroid drugs or radio-iodine, but neglect the underlying immunological mechanisms. Although Graves' disease is often seen as a prototype for an autoimmune mechanism, it is more likely to be a heterogeneous syndrome showing characteristics of both autoimmunity and immunodeficiency. Read More

    Comparative frequency of four different types of pregnancy-associated thyrotoxicosis in a single thyroid centre.
    Thyroid Res 2017 8;10. Epub 2017 Aug 8.
    Kuma Hospital, Centre for Excellence in Thyroid Care, 8-2-35 Shimoyamate-dori, Chuo-ku, Kobe, 650-0011 Japan.
    Background: Pregnancy and delivery markedly influence thyroid function. However, the comparative prevalence of gestational thyrotoxicosis (GT), new onset of Graves' disease during pregnancy (GD during pregnancy), postpartum destructive thyrotoxicosis (PPT), and postpartum Graves' thyrotoxicosis (PPGD) has not yet been determined.

    Methods: We prospectively registered and performed a review of 4127 consecutive non treated female patients with thyrotoxicosis, seen between August 2008 and December 2013 in our outpatient clinic of Kuma Hospital. Read More

    Sex disparities in cancer incidence in Jiashan County, China, 1995-2014.
    Cancer Epidemiol 2017 Aug 10;50(Pt A):46-52. Epub 2017 Aug 10.
    Department of Epidemiology and Health Statistics, School of Public Health, Zhejiang University, Hangzhou, China. Electronic address:
    Purpose: To describe the sex-specific incidence rates and the male-to-female incidence-rate ratios (IRRs) of different cancer types, and to explore the corresponding sex disparities in an area of Eastern China.

    Methods: We used data from the Cancer Registry in Jiashan County, and calculated the sex-specific age-standardized (2010 China standard population) incidence rates and the male-to-female IRRs for different cancer types during the period 1995-2014.

    Results: The age-standardized incidence rates of all cancers for the whole period 1995-2014 were 151. Read More

    Prognostic markers in well differentiated papillary and follicular thyroid cancer (WDTC).
    Eur J Surg Oncol 2017 Aug 3. Epub 2017 Aug 3.
    Department of Otolaryngology, Head and Neck Surgery, Beaumont Hospital, The Royal College of Surgeons in Ireland, Ireland.
    Objectives: WDTC (papillary and follicular thyroid cancer) make up around 90% of all thyroid tumours. Overall, the prognosis in patients with WDTC is excellent. However, there are small cohorts of patients who experience a more aggressive form of disease which is often associated with certain poor prognostic factors. Read More

    Liver toxicity of chemotherapy and targeted therapy for breast cancer patients with hepatitis virus infection.
    Breast 2017 Aug 8;35:191-195. Epub 2017 Aug 8.
    Department of Thyroid and Breast Surgery, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510000, China. Electronic address:
    Background: Chemotherapy has greatly improved the prognosis of breast cancer patients. However, it may also result in undesirable side effects such as hepatitis virus reactivation. Little information is available on the liver toxicity of chemotherapy and targeted therapy for breast cancer patients with hepatitis virus (HBV/HCV) infection. Read More

    Safety evaluation of combination carboplatin and toceranib phosphate (Palladia) in tumour-bearing dogs: A phase I dose finding study.
    Vet Comp Oncol 2017 Aug 10. Epub 2017 Aug 10.
    Department of Clinical Sciences, Kansas State University, College of Veterinary Medicine, Manhattan, Kansas.
    Combining conventional cytotoxic maximum tolerated dose (MTD) chemotherapy with low-dose metronomic and/or anti-angiogenic agents is a exciting area of oncologic research. The objective of this study was to establish the MTD, safety and adverse event (AE) profile of 1 such drug combination. This prospective phase I dose-finding clinical trial assumed an open-label 3 + 3 cohort design. Read More

    Rationalisation of the Irrational Neuropathological Basis of Hypothyroidism-Olfaction Disorders Paradox: Experimental Study.
    World Neurosurg 2017 Aug 7. Epub 2017 Aug 7.
    Department of Pathology, Medical Faculty of Ataturk University, Erzurum-Turkey.
    Objective: Hypothyroidism is defined as an underactive thyroid gland and one of the reasons for inadequate stimulation of thyroid is dysfunction of the hormone regulating brain centers. Olfaction disorders have been considered as a problem in hypothyroidism. It has been hypothesised that olfaction disorders reduce olfactory stimulation and diminished olfactory stimulus may trigger hypothyroidism. Read More

    Prevalence, Correlates, and Time Trends of Multiple Chronic Conditions Among Israeli Adults: Estimates From the Israeli National Health Interview Survey, 2014-2015.
    Prev Chronic Dis 2017 Aug 10;14:E64. Epub 2017 Aug 10.
    Israel Center for Disease Control, Israel Ministry of Health, Jerusalem, Israel.
    Introduction: Chronic diseases constitute a major public health challenge. The prevalence of multiple chronic conditions (MCC) has increased. The objective of our study was to describe the prevalence, correlates, and time trends of MCC in the Israeli population and among the nation's 2 main population groups (Jewish and Arab). Read More

    Evaluation of in vitro and in vivo activity of a multityrosine kinase inhibitor, AL3810, against human thyroid cancer.
    Acta Pharmacol Sin 2017 Aug 10. Epub 2017 Aug 10.
    Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
    Thyroid cancer is the most common type of endocrine neoplasia. Despite recent breakthroughs in treatment of the disease, the treatment of advanced, progressive thyroid cancers remains challenging with limited therapeutic options available. In this study, we evaluated a novel and orally bioavailable small-molecule multiple tyrosine kinases inhibitor, AL3810, in preclinical models of thyroid cancer in vitro and in vivo. Read More

    Sex, Symptom Severity, and Quality of Life in Rheumatology.
    Clin Rev Allergy Immunol 2017 Aug 9. Epub 2017 Aug 9.
    Rheumatology Unit, Clinic for Gastroenterology und Rheumatology, Department of Internal Medicine, Neurology and Dermatology, University of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany.
    Inflammatory rheumatic diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) show a striking female predominance ranging from 3:1 in RA up to 9:1 in SLE. The background for those gender bias is not fully understood yet, but seems to be the result of a complex interaction between sex hormones, (epi-)genetics, and possibly even the composition of gut microbiota. Moreover, time of disease onset, the clinical phenotype including co-morbidities as well as the course of the diseases during life differ between genders. Read More

    Single nucleotide polymorphism 1623 A/G (rs180195) in the promoter of the Thyroglobulin gene is associated with autoimmune thyroid disease but not with thyroid ophthalmopathy.
    Clin Ophthalmol 2017 25;11:1337-1345. Epub 2017 Jul 25.
    Thyroid Research Laboratory, Sydney Medical School - Nepean Clinical School, The University of Sydney, Kingswood, NSW, Australia.
    Background: Our studies over recent years have focused on some new ideas concerning the pathogenesis for the orbital reaction that characterizes Graves' ophthalmopathy namely, that there are antigens expressed by thyroid tissue and orbital tissue where they are targeted by autoantibodies and/or sensitized T cells, leading to orbital inflammation. While this has been well studied for the thyroid stimulating hormone-receptor, the possible role of another major thyroid antigen, Thyroglobulin (TG), has been largely ignored.

    Methods: We identified novel variant 1623 A/G single nucleotide polymorphism (SNP) (rs180195) in the promoter of TG gene associated with autoimmune thyroid disorders. Read More

    Comparative histopathological analysis of sporadic pediatric papillary thyroid carcinoma from Japan and Ukraine.
    Endocr J 2017 Aug 10. Epub 2017 Aug 10.
    Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523, Japan.
    This study set out to compare structural and invasive characteristics of sporadic papillary thyroid carcinoma (PTC) in age-matched groups of children and adolescents of Japan and Ukraine to provide detailed histopathological analysis of tumors from different geographical areas with different iodine intake. A total of 348 (160 Japanese and 188 Ukrainian) PTCs from patients without radiation history were analyzed initially as a combined pediatric group and then subdivided into childhood (aged ≤14 years) and adolescent (aged from 15 to ≤18 years) age series. On multivariate comparison, the Japanese pediatric PTC was characterized by a higher sex ratio (p=1. Read More

    Non-surgical treatment for eyelid retraction in thyroid eye disease (TED).
    Br J Ophthalmol 2017 Aug 9. Epub 2017 Aug 9.
    Scheie Eye Institute, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
    Thyroid eye disease (TED) is an autoimmune condition with an unpredictable course that may lead to permanent facial disfigurement. Eyelid retraction is one of the most common findings, and frequently demands attention due to ocular exposure and impaired cosmesis. Surgical treatment remains the most effective option, but there is a role for temporary corrections during the active phase of the disease, as well as in patients who are poor surgical candidates. Read More

    Factors Associated With Discordance Between Preoperative Parathyroid 4-Dimensional Computed Tomographic Scans and Intraoperative Findings During Parathyroidectomy.
    JAMA Surg 2017 Aug 9. Epub 2017 Aug 9.
    Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles.
    Importance: Parathyroid 4-dimensional computed tomographic scans (4D-CTs) have emerged as an accurate and cost-effective initial localization study for patients with primary hyperparathyroidism. However, potential limitations and factors affecting the accuracy of preoperative 4D-CTs remain poorly defined.

    Objectives: To characterize factors associated with missed parathyroid lesions on preoperative 4D-CTs and to investigate patterns of commonly observed errors. Read More

    Disease Severity at Presentation in Patients with Disease-Related Mortality from Differentiated Thyroid Cancer: Implications for the 2015 ATA Guidelines.
    Thyroid 2017 Aug 9. Epub 2017 Aug 9.
    Rabin Medical Center, 36632, Head & Neck Oncology Service, Davidoff Center, Petah Tikva, Israel.
    Background: The current trend of less aggressive treatment of low-risk differentiated thyroid cancer (DTC) patients was recently challenged by a study reporting >10% disease-related mortality (DRM) in low-risk patients ablated with radioiodine activity of <54mCi. However, this study and others were limited by incomplete data on disease severity at presentation. Whether patients presenting with low risk disease are at risk for disease-related mortality is crucial for planning current treatment strategies. Read More

    Detection of malignancy among suspicious thyroid nodules less than 1 cm on ultrasound with various thyroid image reporting and data systems.
    Thyroid 2017 Aug 9. Epub 2017 Aug 9.
    Chung-Ang University College of Medicine, Department of Radiology , 224-1, Heukseok-dong, Dongjak-gu , Seoul, Korea, Republic of , 156-755 ;
    Background: In patients undergoing active surveillance of papillary thyroid microcarcinoma (PTMC), definitive therapy-usually preceded by a definitive diagnostic procedure-is not recommended until evidence of disease progression is obtained, as stated in the American Thyroid Association (ATA) guidelines. This is because the deferring of definitive diagnosis and therapy until disease progression has no impact on the disease-specific survival. Here, we evaluated the malignancy rate and probability of thyroid nodules, which was further stratified based on the size cut-off value of 1 cm, with suspicious findings on ultrasonography (US), by using various malignant stratification systems. Read More

    Serum leptin levels and GHR-d3/fl gene polymorphism in acromegalic patients with thyroid nodules.
    Adv Clin Exp Med 2017 Mar-Apr;26(2):281-286
    Department of Endocrinology and Metabolism, Pamukkale University, Denizli, Turkey.
    Background: Acromegaly is a rare and serious syndrome that is commonly associated with pituitary neoplasms. Thyroid multinodular disease is a common finding in acromegaly. Leptin is a polypeptide hormone, and studies have shown that it can increase cell proliferation and inhibit apoptosis. Read More

    IL-6, IL-8 and TNF-α levels correlate with disease stage in breast cancer patients.
    Adv Clin Exp Med 2017 May-Jun;26(3):421-426
    Department of Pathogenic Microbiology and Immunology, Xi'an Jiaotong University Health Science Center, Xi'an, China.
    Background: Breast cancer is the most common cancer in Chinese women. Inflammation contributes to tumor progression and can be induced by excessive production of pro-inflammatory cytokines such as interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α). However, how their levels relate to the expression of estrogen receptors (ER), progesterone receptors (PR) and human epidermal growth factor receptor 2 (HER2) by the tumor has not been investigated. Read More

    Potential Role of Metabolic Intervention in the Management of Advanced Differentiated Thyroid Cancer.
    Front Oncol 2017 25;7:160. Epub 2017 Jul 25.
    Endocrinology, Diabetes and Metabolism, Warren Alpert Medical School of Brown University, Providence, RI, United States.
    Well-differentiated thyroid carcinoma (DTC) is the most common endocrine malignancy that has an excellent prognosis with a 5-year survival rate of about 98%. However, approximately 50% of the patients with DTC who present with distant metastases (advanced DTC) die from the disease within 5 years of initial diagnosis even after getting the appropriate therapy. Apart from recent advancements in chemotherapy agents, the potential role of metabolic interventions, including the use of metformin, ketogenic diet, and high-dose vitamin C in the management of advanced cancers have been investigated as a less toxic co-adjuvant therapies. Read More

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