165,048 results match your criteria Thyroid Disease


Pseudolaric acid B exhibits anti-cancer activity on human hepatocellular carcinoma through inhibition of multiple carcinogenic signaling pathways.

Phytomedicine 2018 Nov 19;59:152759. Epub 2018 Nov 19.

Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu, China. Electronic address:

Background: Pseudolaric acid B (PAB), a diterpene acid isolated from the root bark of Pseudolarix kaempferi, exhibits a potent anti-cancer activity in a variety of tumor cells.

Purpose: The present study was designed to evaluate the anti-cancer effects of PAB on hepatocellular carcinoma (HCC) cell lines in vitro, and to explore the underlying mechanism.

Methods: The anti-proliferative activity of PAB on HCC cells were assessed via sulforhodamine B staining, colony formation, cell cycle analysis, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phymed.2018.11.019DOI Listing
November 2018

Is there a correlation between thyroiditis and thyroid cancer?

Endocrine 2019 Apr 19. Epub 2019 Apr 19.

Department of Clinical and Experimental Medicine, University Hospital of Parma, Parma, Italy.

Background: In the past few decades, the incidence of thyroid cancer has increased significantly all over the world. In the same period, there also seems to have been an increase in the incidence of Hashimoto's Thyroiditis-the most common inflammatory autoimmune thyroid disease. Several studies have linked thyroiditis to thyroid cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12020-019-01935-8DOI Listing

Evaluation of cardiovascular risk by growth-differentiation factor-15 and tissue Doppler imaging in children with subclinical hypothyroidism.

Endocrine 2019 Apr 19. Epub 2019 Apr 19.

Department of Biochemistry, Konya Training and Research Hospital, Konya, Turkey.

Objective: Subclinical hypothyroidism, defined as increased TSH serum levels and normal serum free T4 concentrations, has been associated with an increased risk of heart disease in adults. But, data in children and adolescents are scanty and treatment of subclinical hypothyroidism is controversial. Growth differentiation factor-15 (GDF-15) is a promising biomarker of cardiac remodeling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12020-019-01933-wDOI Listing

Functional and oncological outcomes after retropharyngeal node dissection for papillary thyroid carcinoma.

Eur Arch Otorhinolaryngol 2019 Apr 19. Epub 2019 Apr 19.

Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-Ku, Kobe, Hyogo, 650-0017, Japan.

Background: Papillary thyroid carcinoma frequently metastasizes to central and lateral neck lymph nodes, but metastasis to retropharyngeal lymph nodes (RPLN) is rare.

Patients And Methods: We retrospectively reviewed 16 patients with RPLN metastasis of PTC who underwent therapeutic dissection of RPLN metastases.

Results: Among 16 patients, 7 patients underwent RPLN dissection with initial surgery and remaining 9 patients as salvage surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00405-019-05420-wDOI Listing

A constitutional activating MET mutation makes the genetic link between malignancies and chronic inflammatory diseases.

Clin Cancer Res 2019 Apr 19. Epub 2019 Apr 19.

Inserm U1165, University Paris 7.

Purpose: The genesis of all cancers results from an accumulation of mutations, constitutional and/or acquired when induced by external mutagenic factors. High-speed technologies for genome sequencing have completely changed the study of disease genetics, but with limited knowledge of the functional value of most genetic changes.

Experimental Design: Here, we proposed an innovative individual approach by studying tissue samples from a young woman with an unusual association of breast cancer, polycythemia vera and rheumatoid arthritis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-18-3261DOI Listing

Papillary thyroid carcinoma presenting as a primary renal tumor with multiple pulmonary and bone metastases: a case report.

J Med Case Rep 2019 Apr 20;13(1):95. Epub 2019 Apr 20.

Department of Endocrinology and Metabolism, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.

Background: Papillary thyroid carcinoma is the most common endocrine malignancy. Distant metastasis from differentiated thyroid carcinoma is infrequent and the metastasis rate of papillary thyroid carcinoma is lower than that of follicular thyroid carcinoma. Distant metastases from differentiated thyroid carcinoma are usually seen in the lungs and bones; however, renal metastasis is very rare. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13256-019-2025-8DOI Listing

Risk factors for gestational diabetes: An umbrella review of meta-analyses of observational studies.

PLoS One 2019 19;14(4):e0215372. Epub 2019 Apr 19.

Cyprus International Institute for Environmental & Public Health, Cyprus University of Technology, Limassol, Cyprus.

Background/objective: Gestational diabetes mellitus (GDM) is a common pregnancy complication, with complex disease mechanisms, and several risk factors may contribute to its onset. We performed an umbrella review to summarize the evidence from meta-analyses of observational studies on risk factors associated with GDM, evaluate whether there are indications of biases in this literature and identify which of the previously reported associations are supported by convincing evidence.

Methods: We searched PubMed and ISI Web of Science from inception to December 2018 to identify meta-analyses examining associations between putative risk factors for GDM. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215372PLOS

The association between clinical and laboratory parameters in thyroid disease and nonthyroidal illness in young women.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2950-2959

Department of Biochemistry and Clinical Chemistry, Medical University of Warsaw, Warsaw, Poland.

Objective: Evidence from epidemiological and clinical studies strongly suggest that young women in the preconception period are a group at risk for thyroid disorders which may lead to further aggravation of pre-existing chronic thyroid disease and complications during pregnancy.

Materials And Methods: This paper is a literature review focusing on articles published in English between 2014-2017 searched in Medline database using terms 'young women', 'subclinical hyperthyroidism', 'subclinical hypothyroidism', 'nonthyroidal illness syndrome', 'obesity', 'depression'.

Conclusions: Clinical assessment of young female patient including that of obtaining full medical history with a focus on the perceived changes in appearance, psychological symptoms and menstrual irregularities supported by laboratory tests indicative of metabolic status and characteristic changes in thyroid functions, may be the key to well-reasoned and justified individual therapeutic decisions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.26355/eurrev_201904_17575DOI Listing

Intestinal Perforation in ACTH-Dependent Cushing's Syndrome.

Biomed Res Int 2019 13;2019:9721781. Epub 2019 Mar 13.

Division of Endocrinology and Metabolism, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2S2.

Previous studies have linked systemic glucocorticoid use with intestinal perforation. However, the association between intestinal perforation and endogenous hypercortisolism has not been well described, with only 14 previously published case reports. In this study, we investigated if intestinal perforation occurred more frequently in patients with ectopic ACTH syndrome and in those with a greater than 10-fold elevation of 24-hour urinary free cortisol level. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/9721781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436364PMC

Time for a reassessment of the treatment of hypothyroidism.

BMC Endocr Disord 2019 Apr 18;19(1):37. Epub 2019 Apr 18.

, 113 Andersons Road, Yandina, QLD 4561, Australia.

Background: In the treatment for hypothyroidism, a historically symptom-orientated approach has given way to reliance on a single biochemical parameter, thyroid stimulating hormone (TSH).

Main Body: The historical developments and motivation leading to that decision and its potential implications are explored from pathophysiological, clinical and statistical viewpoints. An increasing frequency of hypothyroid-like complaints is noted in patients in the wake of this directional shift, together with relaxation of treatment targets. Read More

View Article

Download full-text PDF

Source
https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
Publisher Site
http://dx.doi.org/10.1186/s12902-019-0365-4DOI Listing
April 2019
1 Read

MADD silencing enhances anti-tumor activity of TRAIL in anaplastic thyroid cancer.

Endocr Relat Cancer 2019 Jun;26(6):551-563

Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA.

ATC is an aggressive disease with limited therapeutic options due to drug resistance. TRAIL is an attractive anti-cancer therapy that can trigger apoptosis in a cancer cell-selective manner. However, TRAIL resistance is a major clinical obstacle for its use as a therapeutic drug. Read More

View Article

Download full-text PDF

Source
https://erc.bioscientifica.com/view/journals/erc/26/6/ERC-18
Publisher Site
http://dx.doi.org/10.1530/ERC-18-0517DOI Listing
June 2019
1 Read
4.805 Impact Factor

Spindle Epithelial Tumor with Thymus-Like Differentiation (SETTLE): A Case Report.

Fetal Pediatr Pathol 2019 Apr 18:1-7. Epub 2019 Apr 18.

c Division of Anatomical Pathology , University of British Columbia , Vancouver , BC , Canada.

Background: Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a tumor with an indolent disease course and late metastatic potential. It occurs primarily in children and adolescents, although it can present later in life. It was first described by Chan and Rosai [Tumors of the neck showing thymic or related branchial pouch differentiation: a unifying concept. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/15513815.2019.1
Publisher Site
http://dx.doi.org/10.1080/15513815.2019.1600625DOI Listing
April 2019
1 Read

Implementing a central composite design for the optimization of solid phase microextraction to establish the urinary volatomic expression: a first approach for breast cancer.

Metabolomics 2019 Apr 17;15(4):64. Epub 2019 Apr 17.

CQM-Centro de Química da Madeira, Universidade da Madeira, Campus Universitário da Penteada, 9020-105, Funchal, Portugal.

Introduction: Breast cancer (BC) is positioned as the second among all cancers remaining at the top of women´s diseases worldwide followed by colorectum, lung, cervix, and thyroid cancers. The main drawback of most the screening/diagnostic methods is their low sensitivity/specificity and in some cases the invasive procedure required to obtain the samples.

Objectives: On the present investigation, we report a statistical design was to evaluate by central composite design the influence towards the optimization of the most significant variables of solid-phase microextraction (SPME) procedure for the isolation of volatile organic metabolites (VOMs) from urine of BC patients (N = 31) and healthy individuals (CTL; N = 40). Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11306-019-1525-2
Publisher Site
http://dx.doi.org/10.1007/s11306-019-1525-2DOI Listing
April 2019
2 Reads

Paraganglioma of the tongue with SDHB gene mutation in a patient with Graves' disease.

Clin Case Rep 2019 Apr 2;7(4):726-730. Epub 2019 Mar 2.

Hereditary Endocrine Cancer, Human Cancer Genetics Programme Spanish National Cancer Centre (CNIO) Madrid Spain.

We report a case of an apparently sporadic paraganglioma of the tongue with a germ-line mutation in a female patient with asymptomatic Graves' disease. The tongue is an unusual primary location. Genetic testing is mandatory in all cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ccr3.2065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452525PMC
April 2019
1 Read

Clinical features and outcomes of diffuse large B-cell lymphoma based on nodal or extranodal primary sites of origin: Analysis of 1,085 WHO classified cases in a single institution in China.

Chin J Cancer Res 2019 Feb;31(1):152-161

Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Objective: To explore the clinicobiologic features and outcomes of diffuse large B-cell lymphoma (DLBCL) patients in China according to the primary site.

Methods: A total of 1,085 patients diagnosed with DLBCL in National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College during a 6-year period were enrolled. Their clinical characteristics and outcomes were analyzed according to the primary site. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.01.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433587PMC
February 2019
1 Read

Incidence and mortality of thyroid cancer in China, 20082012.

Chin J Cancer Res 2019 Feb;31(1):144-151

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100021, China.

Objective: To analyze the incidence and mortality rates of thyroid cancer (TC) in China from 2008 to 2012.

Methods: Incident and death cases of TC were retrieved from the National Central Cancer Registry (NCCR) database collecting from 135 cancer registries in China during 2008-2012. The crude incidence and mortality rates of TC were calculated by area (urban/rural), region (eastern, middle, western), gender and age group (0, 1-4, 5-9, …, 85+). Read More

View Article

Download full-text PDF

Source
http://article.cjcrcn.org/en/article/doi/10.21147/j.issn.100
Publisher Site
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.01.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433579PMC
February 2019
1 Read

The Delayed Diagnosis of Thyroid Storm in Patients with Psychosis: A Report of Two Cases.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Japan.

We herein report two cases of patients with thyroid storm with a delayed diagnosis due to psychosis. The patients were a 63-year-old woman with bipolar II disorder and a 37-year-old man with major depressive disorder. The psychoses in both patients were well controlled with medication. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2169/internalmedicine.2681-19DOI Listing
April 2019
1 Read

Myelin repair stimulated by CNS-selective thyroid hormone action.

JCI Insight 2019 Apr 18;4(8). Epub 2019 Apr 18.

Department of Physiology & Pharmacology and Program in Chemical Biology, Oregon Health & Science University, Portland, Oregon, USA.

Oligodendrocyte processes wrap axons to form neuroprotective myelin sheaths, and damage to myelin in disorders, such as multiple sclerosis (MS), leads to neurodegeneration and disability. There are currently no approved treatments for MS that stimulate myelin repair. During development, thyroid hormone (TH) promotes myelination through enhancing oligodendrocyte differentiation; however, TH itself is unsuitable as a remyelination therapy due to adverse systemic effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/jci.insight.126329DOI Listing

Acute airway obstruction due to benign multinodular goitre.

BMJ Case Rep 2019 Apr 16;12(4). Epub 2019 Apr 16.

Internal Medicine, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.

Benign multinodular goitre is a common illness. When accompanied by obstructive symptoms, such as dyspnoea, it carries an indication for surgery. Benign multinodular goitres rarely cause acute airway obstruction. Read More

View Article

Download full-text PDF

Source
http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22809
Publisher Site
http://dx.doi.org/10.1136/bcr-2018-228095DOI Listing
April 2019
3 Reads

LATERAL NECK DISSECTION FOR AGGRESSIVE VARIANTS OF WELL-DIFFERENTIATED THYROID CANCER.

Endocr Pract 2019 Apr;25(4):328-334

Well-differentiated thyroid cancer (WDTC) is characterized by favorable disease course and excellent survival. However, some histologic subtypes, known as aggressive histologic variants (AHVs), present a more aggressive behavior than conventional WDTC. The aim of this study was to evaluate the pattern of nodal involvement and factors influencing prognosis in N1b patients with AHVs. Read More

View Article

Download full-text PDF

Source
http://journals.aace.com/doi/10.4158/EP-2018-0503
Publisher Site
http://dx.doi.org/10.4158/EP-2018-0503DOI Listing
April 2019
2 Reads

Risk of incident circulatory disease in patients treated for differentiated thyroid carcinoma with no history of cardiovascular disease.

Clin Endocrinol (Oxf) 2019 Apr 16. Epub 2019 Apr 16.

Institute of Applied Health Research, University of Birmingham, Birmingham, Edgbaston, United Kingdom, B15 2TT.

Context: The incidence of differentiated thyroid cancer (DTC) is increasing, yet the prognosis is favorable and long-term survival is expected. Exogenous TSH suppression has been used for many years to prevent DTC recurrence and may be associated with increased risks of circulatory diseases.

Design: Risks of circulatory disease in patients treated for DTC were compared to randomly matched patients without DTC (controls) up to a 1:5 ratio using age, sex, body mass index (BMI) and smoking as the matching parameters in a population-based, open cohort study using The Health Improvement Network. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13990DOI Listing
April 2019
1 Read

Recent advances in carbohydrate-based cancer vaccines.

Biotechnol Lett 2019 Apr 16. Epub 2019 Apr 16.

Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, 310014, Zhejiang, People's Republic of China.

Cancer is a complex multifactorial disease for which many promising therapeutic strategies such as immunotherapy are emerging. Malignant cells frequently express aberrant cell surface carbohydrates, which differentiate them from normal "healthy" cells. This characteristic presents a window for the development of synthetic carbohydrate antigen-based cancer vaccines which can be recognized by the immune system and can bring about T cell-dependent immune responses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10529-019-02675-5DOI Listing
April 2019
2 Reads

Medullary Thyroid Carcinoma and Papillary Thyroid Carcinoma in the Same Patient as a Collision Tumour.

Case Rep Endocrinol 2019 12;2019:4038628. Epub 2019 Mar 12.

Recep Tayyip Erdoğan University School of Medicine, Department of Pathology, Turkey.

Aim: Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) are two different types of thyroid carcinoma with significant different clinical and histological findings. Their coexistence in the same patient is a very rare event which demands different clinical approach.

Case Report: We report a case with concurrent MTC and PTC in the same thyroid having characteristics of a collision tumour. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/4038628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434312PMC
March 2019
1 Read

[Progression of diagnosis and treatment of medullary thyroid carcinoma].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;54(4):306-310

Department of Head and Neck Surgery, Sichuan Cancer Hospital, Sichuan Institute of Cancer Research, Sichuan Cancer Prevention and Control Center, Cancer Hospital affiliate to School of Medicine, Electronic Science and Technology, Chengdu 610041, China.

To review and summarize recent update on preoperative diagnostic criteria, treatment and postoperative follow-up for medullary thyroid carcinoma. The relevant literatures and guidelines about medullary thyroid carcinoma were analyzed and summarized. In the early stages of the disease radical surgery still dominated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.04.015DOI Listing
April 2019
2 Reads

X-chromosome gene dosage as a determinant of congenital malformations and of age-related comorbidity risk in patients with Turner syndrome, from childhood to early adulthood.

Eur J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

J Leger, Pediatric Endocrinology, Hopital Universitaire Robert-Debre, Paris, France.

Objective Turner Syndrome is associated with several phenotypic conditions associated with a higher risk of subsequent comorbidity. We aimed to evaluate the prevalence of congenital malformations and the occurrence of age-related comorbid conditions, and to determine whether the frequencies of congenital and acquired conditions depend on X-chromosome gene dosage, as a function of karyotype subgroup. Design and Methods This national retrospective observational cohort study includes 1501 patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/EJE-18-0878DOI Listing
April 2019
1 Read

Iodine in Edible Seaweed, Its Absorption, Dietary Use, and Relation to Iodine Nutrition in Arctic People.

J Med Food 2019 Apr;22(4):421-426

3 Ilisimatusarfik, University of Greenland, Nuuk, Greenland.

Dietary iodine is important to human health, and both low and high iodine intake levels increase the risk of disease. Seaweed is rich in iodine and it is a common component in both Asian and in Arctic cuisines. While the intake and impact are known for Asian people, data are lacking for Arctic people. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/jmf.2018.0187DOI Listing
April 2019
1 Read

[Circadian rhythms of thyroid hormones in patients with ischemic heart disease, arterial hypertension, and atrial fibrillation].

Kardiologiia 2019 Apr 13;59(3S):23-29. Epub 2019 Apr 13.

V.I. Razumovsky Saratov State Medical University, Bolshaya Kazachjya 112, Saratov 410012.

Aim: To evaluate the interrelationship between diurnal changes in thyrotropic hormone (TTH), free triiodothyronine (FT3), and clinical features of IHD in combination with AH and atrial fibrillation (AF).

Materials And Methods: Levels of TTH, FT3, and plasma cortisol were measured in 133 patients with IHD and AH with or without paroxysmal AF. The studied indexes included duration of IHD, AH, and AF; presence or absence of AF and AH; incidence rate of AF episodes per week; severity of exertional angina; systolic and diastolic BP; and EchoCG data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18087/cardio.2506DOI Listing
April 2019
1 Read

Ga-PSMA PET thyroid incidentalomas.

Hormones (Athens) 2019 Apr 15. Epub 2019 Apr 15.

Department of Nuclear Medicine and PET/CT Center, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.

Introduction: Thyroid incidentaloma is defined as a thyroid lesion incidentally and newly detected by imaging techniques performed for an unrelated purpose and especially for a non-thyroid disease. The aim of this review is to evaluate the prevalence and clinical significance of focal incidental radiolabelled prostate-specific membrane antigen (PSMA) uptake in the thyroid gland [PSMA thyroid incidentaloma (PTI)] revealed by PET/CT or PET/MRI.

Methods: A comprehensive literature search of the PubMed/MEDLINE, Scopus, and Embase databases was conducted to find relevant published articles about the prevalence and clinical significance of PTIs detected by PET/CT or PET/MRI in patients studied for other oncologic purposes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s42000-019-00106-8DOI Listing
April 2019
1 Read

Pituitary-testicular Axis Dysfunction in Methimazole-induced Hypothyroidism in Rats.

J Vet Res 2019 Mar 22;63(1):161-166. Epub 2019 Mar 22.

Department of Comparative Anatomy and Anthropology, Maria Curie-Skłodowska University, 20-033 Lublin, Poland.

Introduction: Thyroid hormones play a major role in the regulation of testicular maturation and growth and in the control of Sertoli and Leydig cell functions in adulthood. When naturally occurring, hypothyroidism causes male hypogonadotropic hypogonadism and Sertoli cell function disorders, but when iatrogenic and methimazole-induced its influence on the pituitary-testicular axis function with respect to Sertoli cells is poorly known.

Material And Methods: Male adult Wistar rats (n = 14) were divided into two groups: E - taking methimazole orally for 60 days, and C - control animals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2478/jvetres-2019-0008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458557PMC
March 2019
1 Read

The combined effect of mesenchymal stem cells and resveratrol on type 1 diabetic neuropathy.

Exp Ther Med 2019 May 13;17(5):3555-3563. Epub 2019 Mar 13.

Endocrinology Department, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.

Diabetic neuropathy (DN) is one of the most common diabetic complications that results in an increase in patient discomfort and pain. The present study demonstrated that mesenchymal stem cells (MSCs) or resveratrol (RSV) may improve diabetic hyperglycemia and neuropathy. The aim of the present study was to investigate the combined effect of MSCs and RSV on DN. Read More

View Article

Download full-text PDF

Source
http://www.spandidos-publications.com/10.3892/etm.2019.7383
Publisher Site
http://dx.doi.org/10.3892/etm.2019.7383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447822PMC
May 2019
2 Reads

Diffusely Increased F-FDG Uptake in the Thyroid Gland and Risk of Thyroid Dysfunction: A Cohort Study.

J Clin Med 2019 Apr 2;8(4). Epub 2019 Apr 2.

Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 04514 Seoul, Korea.

The impact of incidentally identified diffuse thyroid FDG uptake on F-FDG PET/CT scan on the incidence of thyroid dysfunction remains unclear. We examined the association of diffuse thyroid FDG uptake with the development of thyroid dysfunction. This cohort study involved 39,098 Korean adults who were free of malignancy and thyroid disease at baseline and underwent regular health checkup examinations including an F-FDG whole body PET/CT scan, thyroid-stimulating hormone and free thyroxine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm8040443DOI Listing
April 2019
2 Reads

The Mitochondrial DNA Control Region Might Have Useful Diagnostic and Prognostic Biomarkers for Thyroid Tumors.

Exp Clin Endocrinol Diabetes 2019 Apr 15. Epub 2019 Apr 15.

Faculty of Arts and Sciences, Department of Molecular Biology & Genetics, Tekirdağ Namık Kemal University, Tekirdağ, Turkey.

The literature suggests that mitochondrial DNA (mtDNA) defects are associated with a large number of diseases including cancers. The role of mtDNA variations in thyroid cancer is a highly controversial topic. Therefore, we investigated the role of mt-DNA control region (CR) variations in thyroid tumor progression and the influence of mtDNA haplogroups on susceptibility to thyroid tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0869-7355DOI Listing
April 2019
1 Read

Hypothyroidism is an independent risk factor for Menière's disease: A population-based cohort study.

Medicine (Baltimore) 2019 Apr;98(15):e15166

Department of Emergency Medicine.

The relationship of hypothyroidism and Menière's disease (MD) has been discussed before, yet not well documented. Our study aims to investigate the correlation of both diseases.This is a retrospective cohort study based on data from the LHID2000 (Longitudinal Health Insurance Database 2000), a subset of the Taiwan National Research Health Insurance Database that contains claims data for the 2000 to 2011 period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000015166DOI Listing
April 2019
1 Read

Traditional Chinese medicine for management of recurrent and refractory Crohn disease: A case report.

Medicine (Baltimore) 2019 Apr;98(15):e15148

Department of Thyroid.

Introduction: Crohn disease (CD) is a chronic relapsing systemic inflammatory disease afflicting the gastrointestinal system with a high morbidity. There has been increasing clinical interest in traditional Chinese medicine (TCM) treatment for CD. This report aims to present patient outcome of therapeutic management using TCM in combination with pharmacologic therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000015148DOI Listing
April 2019
1 Read

Hypothyroidism in Pregnancy.

Authors:
Scott A Sullivan

Clin Obstet Gynecol 2019 Apr 10. Epub 2019 Apr 10.

Department of Obstetrics/Gynecology, Division of Maternal-Fetal Medicine, Medical University of South Carolina, Charleston, South Carolina.

Hypothyroidism in pregnancy is defined as the presence of an elevated thyroid stimulating hormone during gestation, affecting 2% to 3% of the population. Overt hypothyroidism is diagnosed by a decreased FT4, while patients with a normal FT4 are considered to have subclinical disease. Poorly controlled disease is associated with both pregnancy complications and developmental delays in the offspring. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/GRF.0000000000000432DOI Listing
April 2019
2 Reads

Determining Specific Thyroid Transcripts in Peripheral Blood: A Single Center Study Experience.

Balkan J Med Genet 2018 Dec 31;21(2):13-20. Epub 2018 Dec 31.

Institute for Forensic Medicine, Criminology and Medical Deontology, Medical Faculty, Skopje, Republic of Macedonia.

Thyroid carcinoma (TC) comprises a spectrum of different tumors with a wide range of biological behavior and prognosis. The techniques based on the latest trends in molecular biology may have application in diagnosis of metastatic TC. The aim of this study was to apply and analyze mRNA expression in peripheral blood of thyrotropin receptor [thyroid stimulating hormone receptor (-mRNA)] gene and thyroglobulin (-mRNA) gene using 2 method in differentiated TC patients and healthy individuals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2478/bjmg-2018-0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454242PMC
December 2018
1 Read

Artificial Intelligence and Machine Learning in Endocrinology and Metabolism: The Dawn of a New Era.

Front Endocrinol (Lausanne) 2019 28;10:185. Epub 2019 Mar 28.

Section on Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fendo.2019.00185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448412PMC
March 2019
1 Read

Thyroid Hormone, Thyroid Hormone Metabolites and Mast Cells: A Less Explored Issue.

Front Cell Neurosci 2019 29;13:79. Epub 2019 Mar 29.

Section of Pharmacology, Department of Neurology, Psychology, Drug Sciences and Child Health, University of Florence, Florence, Italy.

Mast cells are primary players in immune and inflammatory diseases. In the brain, mast cells are located at the brain side of the blood brain barrier (BBB) exerting a crucial role in protecting the brain from xenobiotic invasion. Furthermore, recent advances in neuroscience indicate mast cells may play an important role in glial cell-neuron communication through the release of mediators, including histamine. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fncel.2019.00079
Publisher Site
http://dx.doi.org/10.3389/fncel.2019.00079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449760PMC
March 2019
5 Reads

Prediction of new onset atrial fibrillation in patients with acute pulmonary embolism: The role of sPESI Score.

Turk Kardiyol Dern Ars 2019 Apr;47(3):191-197

Department of Cardiology, Türkiye Yüksek Ihtisas Training and Research Hospital, Ankara, Turkey.

Objective: Acute pulmonary embolism (APE) is a serious clinical situation and atrial fibrillation (AF) is the most common arrhytmia in clinical practice. The Pulmonary Embolism Severity Index (PESI) is an accepted risk stratification tool used to predict short term mortality in APE. The aim of this study was to evaluate the relationship between the PESI score and new-onset AF in patients with APE. Read More

View Article

Download full-text PDF

Source
http://archivestsc.com/jvi.aspx?un=TKDA-78241
Publisher Site
http://dx.doi.org/10.5543/tkda.2018.78241DOI Listing
April 2019
2 Reads

Risk of cardiac arrhythmias in patients with chronic hepatitis B and C infections - A 13-year nationwide population-based study.

J Cardiol 2019 Apr 11. Epub 2019 Apr 11.

Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Chiayi, Taiwan.

Background: Chronic hepatitis C virus (HCV) infection is associated with higher risk of cardiovascular events than chronic hepatitis B virus (HBV). We aimed to investigate whether there is higher risk of arrhythmia in HCV infection.

Methods: Electronic medical records from National Health Institute Research Database during 2000-2012 were retrieved for patients with HBV or HCV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jjcc.2019.03.009DOI Listing
April 2019
2 Reads

The Role of Zinc in Thyroid Hormones Metabolism.

Int J Vitam Nutr Res 2019 Apr 15:1-9. Epub 2019 Apr 15.

1 Nutrition Department, Federal University of Piauí, Campus Minister Petrônio Portella, Ininga, Teresina, Piauí, Brazil.

Thyroid hormones play an important role in body homeostasis by facilitating metabolism of lipids and glucose, regulating metabolic adaptations, responding to changes in energy intake, and controlling thermogenesis. Proper metabolism and action of these hormones requires the participation of various nutrients. Among them is zinc, whose interaction with thyroid hormones is complex. Read More

View Article

Download full-text PDF

Source
https://econtent.hogrefe.com/doi/10.1024/0300-9831/a000262
Publisher Site
http://dx.doi.org/10.1024/0300-9831/a000262DOI Listing
April 2019
2 Reads
1.000 Impact Factor

On the central role of mitochondria dysfunction and oxidative stress in Alzheimer's disease.

Neurol Sci 2019 Apr 13. Epub 2019 Apr 13.

Johns Hopkins University, Baltimore, MD, USA.

Background: Alzheimer's disease (AD) is the commonest cause of dementia, with approximately 5 million new cases occurring annually. Despite decades of research, its complex pathophysiology and etiopathogenesis presents a major hindrance to the development of an effective treatment and prevention strategy. Aging is the biggest risk factor for the development of AD, and the total number of older people in the population is going to significantly increase in the next decades, suggesting that AD incidence and prevalence is likely to increase in the future. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10072-019-03863-xDOI Listing
April 2019
13 Reads

Diagnosis and treatment of confirmed and suspected primary hyperparathyroidism in equids: 17 cases (1999-2016).

Equine Vet J 2019 Apr 13. Epub 2019 Apr 13.

Baker Institute for Animal Health, Cornell University College of Veterinary Medicine, Ithaca, New York, 14853, USA.

Background: Primary hyperparathyroidism is uncommon in equids.

Objectives: To describe the diagnostic findings and efficacy of treatment in equids with primary hyperparathyroidism.

Study Design: Retrospective case series describing sixteen horses and one mule. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/evj.13120
Publisher Site
http://dx.doi.org/10.1111/evj.13120DOI Listing
April 2019
7 Reads

Multimorbidity and Health-Related Quality of Life in Old Age: Role of Functional Dependence and Depressive Symptoms.

J Am Med Dir Assoc 2019 Apr 9. Epub 2019 Apr 9.

Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Stockholm, Sweden; Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China. Electronic address:

Objectives: To examine the associations of multimorbidity patterns with health-related quality of life (HRQL) in rural-dwelling older adults in China, and to explore to what extent their associations were mediated by functional dependence and depressive symptoms.

Design: Population-based cross-sectional study.

Setting And Participants: 1497 participants (age ≥60 years; 66. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jamda.2019.02.024DOI Listing
April 2019
1 Read

Excessive iodine intake is associated with formation of thyroid nodules in pregnant Chinese women.

Nutr Res 2019 Mar 6. Epub 2019 Mar 6.

The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China; Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health. Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin, China. Electronic address:

In recent decades, the prevalence of thyroid nodules (TNs) has steadily increased in pregnant women. Therefore, this study aimed to investigate associations between TNs and iodine intake in pregnant women. From March 2016 to May 2017, serum and spot urine samples, as well as demographic data and medical history, were collected from 2353 pregnant women. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nutres.2019.02.009DOI Listing
March 2019
1 Read

Association of serum deiodinase type 2 level with chronic obstructive pulmonary disease in the Polish population.

Acta Biochim Pol 2019 Apr 12. Epub 2019 Apr 12.

Department of Pulmonology and Allergology, Medical University of Lodz, Łódź, Poland.

Backgrounds: Deiodinase type 2 (DIO2) is a selenoenzyme involved in the synthesis of thyroid hormones. Chemerin is a newly investigated adipokine known also as novel chemokine. Both molecules have been recently expected and found to play an important role in inflammation and immunity. Read More

View Article

Download full-text PDF

Source
https://ojs.ptbioch.edu.pl/index.php/abp/article/view/2761
Publisher Site
http://dx.doi.org/10.18388/abp.2018_2761DOI Listing
April 2019
2 Reads

Drug trends among non-institutionalized Canadians and the impact of data collection changes in the Canadian Health Measures Survey 2007 to 2015.

PLoS One 2019 12;14(4):e0214718. Epub 2019 Apr 12.

Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: There is a global trend of increasing use in prescription and over-the-counter (OTC) drugs. This hasn't been verified in Canada. In addition, there are changes made to the collection method of medication information after the Canadian Health Measures Survey (CHMS) cycle 2. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214718PLOS
April 2019
3 Reads

The impact of severe late-effects after 12 Gy fractionated total body irradiation and allogeneic stem cell transplantation for childhood leukemia (1988-2010).

Pediatr Hematol Oncol 2019 Apr 12:1-17. Epub 2019 Apr 12.

c Host Research Team EA4607 SNA-EPIS, PRES Lyon, Jean Monnet University, University Hospital , Saint-Etienne , France.

This study consists of a retrospective study including 71 childhood leukemia survivors (36 females) treated with allo-HSCT 12 Gy fractionated total body irradiation (fTBI) conditioning, with a median age of 25.0 y at time of follow-up and a median delay of 14.8 y since the graft. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08880018.2019.1591549DOI Listing
April 2019
1 Read

Efficacy of two-weekly nanoparticle albumin-bound paclitaxel as neoadjuvant chemotherapy for breast cancer.

Nanomedicine (Lond) 2019 Apr 12. Epub 2019 Apr 12.

Breast Disease Department, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, PR China.

Aim: Compare the two-weekly regimens of nanoparticle albumin-bound paclitaxel (nab-P) with solvent-based paclitaxel (sb-P) as neoadjuvant chemotherapy for breast cancer.

Materials & Methods: Patients (n = 162) with operable early breast cancer received four cycles of dose-dense epirubicin and cyclophosphamide followed by four two-weekly cycles of nab-P (n = 83) or sb-P (n = 79), with trastuzumab when needed.

Results: Across all the patients, the ypT0 ypN0 and ypT0/is ypN0 pathological complete response rates in the nab-P group were not superior to those in the sb-P group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/nnm-2018-0485DOI Listing
April 2019
1 Read
5.413 Impact Factor