164,068 results match your criteria Thyroid Disease


Stimulated thyroglobulin and Thyroglobulin Reduction Index Predict Excellent Response in Differentiated Thyroid Cancers.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

CHU Clermont-Ferrand, Service d'endocrinologie, diabétologie et maladies métaboliques, Clermont-Ferrand, France.

Introduction: Despite its good prognosis, differentiated thyroid cancer (DTC) is characterized by a high risk of disease persistence and/or recurrence. Estimation of long-term remission (excellent response) thanks to specific parameters could help to personalize the schedule of active surveillance.

Objective: Evaluation of the value of stimulated thyroglobulin and thyroglobulin reduction index (TRI) to predict long-term remission in patients with DTC managed by thyroidectomy and radioactive iodine (RAI) remnant ablation. Read More

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http://dx.doi.org/10.1210/jc.2018-02680DOI Listing
February 2019

Improving risk stratification strategies for thyroid disease during pregnancy.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

Depts. of Internal Medicine, Erasmus University Medical Center, the Netherlands.

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http://dx.doi.org/10.1210/jc.2019-00336DOI Listing
February 2019

Clinical Features and Comorbidities of Patients With Necrobiosis Lipoidica With or Without Diabetes.

JAMA Dermatol 2019 Feb 20. Epub 2019 Feb 20.

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

Importance: Necrobiosis lipoidica (NL) is a rare granulomatous condition. Current knowledge of its key features is based on a limited number of studies and case reports, leading to wide variability in the characterization of its defining features, with limited comparison of patients with or without diabetes.

Objective: To evaluate the epidemiologic characteristics, clinical features, and disease associations of NL in patients with or without type 1 or 2 diabetes. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.5635DOI Listing
February 2019

Thyroid disorders in Brazil: the contribution of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

Authors:
I M Bensenor

Braz J Med Biol Res 2019 Feb 14;52(2):e8417. Epub 2019 Feb 14.

Centro de Pesquisa Clínica e Epidemiológica, Hospital Universitário, Universidade de São Paulo, São Paulo, SP, Brasil.

Thyroid disorders are common diseases, both in Brazil and worldwide. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a prospective cohort study that investigates cardiovascular diseases, diabetes, and associated factors, including non-classical cardiovascular risk factors such as thyroid function. Thyroid function was classified according to thyrotropin stimulating hormone (TSH), free thyroxine (FT4), and use of medication to treat thyroid disorders, after excluding participants who reported use of any medication that could alter the results of the TSH and FT4 tests. Read More

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http://dx.doi.org/10.1590/1414-431X20198417DOI Listing
February 2019

Defining and listing very rare cancers of paediatric age: consensus of the Joint Action on Rare Cancers in cooperation with the European Cooperative Study Group for Pediatric Rare Tumors.

Eur J Cancer 2019 Feb 19;110:120-126. Epub 2019 Feb 19.

Department of Epidemiological Research and Molecular Medicine, Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Italy. Electronic address:

Although all tumours are rare in childhood, there are some particularly rare paediatric cancers which have not benefited from advances made by the international paediatric oncology network. To establish a shared definition and produce a list of these entities, the European Union Joint Action on Rare Cancers (JARC) promoted a consensus effort. The definition was based on the incidence rates estimated using the information network on rare cancers (RARECAREnet) database, pooling data from 94 population-based cancer registries and 27 countries. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.12.031DOI Listing
February 2019

Thyroid Hormones in Critical Illness.

Crit Care Clin 2019 Apr 24;35(2):375-388. Epub 2019 Jan 24.

Endocrine and Metabolic Unit, Royal Adelaide Hospital, Port Road, Adelaide, South Australia 5000, Australia.

Thyroid hormone is integral for normal function, yet during illness, circulating levels of the most active form (triiodothyronine [T3]) decline. Whether this is an adaptive response in critical illness or contributes to progressive disease has remained controversial. This review outlines the basis of thyroid hormone changes during critical illness and considers the evidence regarding T3 replacement. Read More

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http://dx.doi.org/10.1016/j.ccc.2018.11.012DOI Listing

The JAK/STAT3 and NF-κB signaling pathways regulate cancer stem cell properties in anaplastic thyroid cancer cells.

Thyroid 2019 Feb 20. Epub 2019 Feb 20.

Nagasaki University, Radiation Medical Sciences, Atomic Bomb Disease Institute , 1-12-4 Sakamoto , Nagasaki, Japan , 852-8523 ;

Background: Anaplastic thyroid carcinoma (ATC) is still one of the most aggressive cancers, and a therapy with a new concept needs to be developed. Recently, the research of cancer stem cells (CSCs) has been progressed, and CSCs have been suggested to be responsible for metastasis, recurrence, and therapy resistance. In ATC-CSCs, aldehyde dehydrogenase (ALDH) activity is the most reliable marker to enrich the CSCs; however, it itself is just a marker and is not involved in CSC properties. Read More

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http://dx.doi.org/10.1089/thy.2018.0212DOI Listing
February 2019

Tc-Pertechnetate Scintigraphy Predicts Successful Postoperative Ablation in Differentiated Thyroid Carcinoma Patients Treated with Low Radioiodine Activities.

Endocrinol Metab (Seoul) 2019 Feb 15. Epub 2019 Feb 15.

Clinic for Nuclear Medicine and Competence Center for Thyroid Diseases, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.

Background: Postoperative routine radioiodine (RAI) treatment is currently debated for patients with low-risk differentiated thyroid carcinoma (DTC) patients. If performed, a low ¹³¹I activity (i.e. Read More

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February 2019

Cost for treatment and follow-up of thyroid cancer increases according to the severity of disease.

Head Neck 2019 Feb 19. Epub 2019 Feb 19.

Department of Surgery, Thyroid Cancer Center, Gangnam Severance Hospital, Institute of Refractory Thyroid Cancer, Yonsei University College of Medicine, Seoul, Korea.

Background: The aim of this study was to provide an analysis of thyroid cancer-related health care costs over a 5-year period, according to the extent of thyroid surgery.

Methods: The study included 33 patients from our institutional database who underwent thyroid cancer surgery in 2010. Patients were divided into four groups based on surgical extent: (1) hemithyroidectomy, (2) total thyroidectomy, (3) total thyroidectomy with ipsilateral radical neck dissection, and (4) total thyroidectomy with bilateral radical neck dissection and mediastinal dissection. Read More

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http://dx.doi.org/10.1002/hed.25706DOI Listing
February 2019

Prevalence of diabetes and presence of autoantibodies against zinc transporter 8 and glutamic decarboxylase at diagnosis and at follow up of Graves' disease.

Endocrine 2019 Feb 19. Epub 2019 Feb 19.

Department of Endocrinology, Lund University, SE-221 00, Lund, Sweden.

Purpose: The aim of this work was to investigate, in patients with newly diagnosed Graves' disease (GD), the frequency of islet autoantibodies including autoantibodies against Zink transporter 8 (ZnT8A), as well as to investigate the relation between thyroid autoantibodies, islet autoantibodies and diabetes both before GD diagnosis and at follow-up.

Methods: Blood samples from 278 patients with newly diagnosed GD were analyzed for autoantibodies against glutamic acid decarboxylase (GADA), insulinoma-associated protein-2 (IA2-A), three variants of zinc transporter 8 (ZnT8A), thyroid peroxidase (TPOA) and the TSH receptor (TRAb). Information on other autoimmune diseases, as well as development of diabetes during follow up was gathered from patient's medical journal. Read More

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http://dx.doi.org/10.1007/s12020-019-01852-wDOI Listing
February 2019
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Development of a binational thyroid cancer clinical quality registry: a protocol paper.

BMJ Open 2019 Jan 28;9(1):e023723. Epub 2019 Jan 28.

Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Introduction: The occurrence of thyroid cancer is increasing throughout the developed world and since the 1990s has become the fastest increasing malignancy. In 2014, a total of 2693 Australians and 302 New Zealanders were diagnosed with thyroid cancer, with this number projected to rise to 3650 in 2018. The purpose of this protocol is to establish a binational population-based clinical quality registry with the aim of monitoring and improving the quality of care provided to patients diagnosed with thyroid cancer in Australia and New Zealand. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023723DOI Listing
January 2019

Efficacy and safety of levothyroxine (L-T4) replacement on the exercise capability in chronic systolic heart failure patients with subclinical hypothyroidism: Study protocol for a multi-center, open label, randomized, parallel group trial (ThyroHeart-CHF).

Trials 2019 Feb 19;20(1):143. Epub 2019 Feb 19.

Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Xicheng District, Beijing, 100037, China.

Background: Subclinical hypothyroidism is a common condition in patients with heart failure and is defined as elevated serum thyroid hormone (TSH) with normal circulating free thyroxine (FT4). Evidence on the effect of thyroid hormone treatment is lacking. We designed a randomized controlled trial to compare the efficacy and safety of thyroid hormone supplementation in patients with chronic heart failure complicated with subclinical hypothyroidism. Read More

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http://dx.doi.org/10.1186/s13063-019-3219-5DOI Listing
February 2019

The dilemma of metastatic medullary thyroid carcinoma: when to start systemic treatment.

Tumori 2019 Feb 19:300891619829571. Epub 2019 Feb 19.

2 Head and Neck Cancer Medical Oncology 3 Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Purpose:: Two tyrosine kinase inhibitors (TKIs), vandetanib and cabozantinib, have been approved for recurrent/metastatic (R/M) medullary thyroid carcinoma (MTC). To date, it is still debated when and which TKI has to be started in R/M MTC patients. This is due to 1) TKI-related toxicity burden, 2) no overall survival benefit for either TKI, and 3) progression-free survival improvement in MTC subgroups ( RETM918T and RAS mutations) treated with cabozantinib. Read More

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http://dx.doi.org/10.1177/0300891619829571DOI Listing
February 2019

Association studies of the SAS-ZFAT, IL-23R, IFIH1 and FOXP3 genes in autoimmune thyroid disease.

Expert Rev Endocrinol Metab 2009 Jul;4(4):325-331

b Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan.

Autoimmune thyroid diseases (AITDs) are complex diseases caused by an interaction between susceptibility genes and environmental triggers. Genetic susceptibility in combination with external factors, such as dietary iodine, is believed to initiate the autoimmune response against thyroid antigens. Abundant epidemiological data, including family and twin studies, point to a strong genetic influence in the development of AITDs. Read More

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http://dx.doi.org/10.1586/eem.09.21DOI Listing

Radioactive iodine-refractory differentiated thyroid cancer: unmet needs and future directions.

Expert Rev Endocrinol Metab 2012 Sep;7(5):541-554

f Massachusetts General Hospital, Boston, MA, USA.

Approximately 90% of thyroid cancers are differentiated (DTCs) and have papillary, follicular or Hürthle cell morphology. Although treatment with surgery and radioactive iodine (I-131; RAI), as appropriate, is associated with significant cure rates and survival benefits, clonal disease progression with development of refractoriness to RAI poses a major therapeutic challenge in about 15% of patients. Traditional chemotherapeutic agents are relatively ineffective and are associated with significant toxicities. Read More

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http://dx.doi.org/10.1586/eem.12.36DOI Listing
September 2012

Brain regional thyroid hormone status and Dio3: where genetics, epigenetics and psychiatric vulnerability meet.

Expert Rev Endocrinol Metab 2011 Sep;6(5):649-652

a Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1586/eem.11.64DOI Listing
September 2011

Update on the molecular signature of differentiated thyroid cancer: clinical implications and potential opportunities.

Expert Rev Endocrinol Metab 2011 Nov;6(6):819-834

d Division of Endocrinology, Department of Pediatrics, Children's Hospital of Richmond at The Commonwealth University Health System, Medical College of Virginia, Richmond, VA, USA.

With the development and maturation of new technologies, there has been a steady incorporation of powerful new tools into the evaluation and management of thyroid nodules and thyroid cancer. An increasing number of reports on oncogene testing and molecular screening in fine-needle aspiration biopsy samples have been published. However, there remains a paucity of data and consensus on combining both conventional and molecular technologies to determine the diagnosis and/or prognosis of disease. Read More

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http://dx.doi.org/10.1586/eem.11.68DOI Listing
November 2011

Managing anaplastic thyroid carcinoma.

Expert Rev Endocrinol Metab 2011 Nov;6(6):793-809

a Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, USA.

Anaplastic thyroid cancer is one of the most lethal malignancies, with dismal prognosis, resistance to multimodal treatments and a median survival of only 5-6 months. Advances in the discovery of genetic pathway aberrations involved in this aggressive disease have been made, and multiple novel therapies targeting these pathways are undergoing clinical trials. So far, there is no single effective treatment for this disease; however, multimodal therapies with a combination of surgery, radiation and chemotherapy hold some promise. Read More

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http://dx.doi.org/10.1586/eem.11.76DOI Listing
November 2011

Prophylactic thyroidectomy in multiple endocrine neoplasia type 2.

Expert Rev Endocrinol Metab 2010 Nov;5(6):867-874

a Endocrine Practice and Molecular Laboratory, Brückenstr. 21, 69120 Heidelberg, Germany.

Medullary thyroid carcinoma (MTC) is the main component of the autosomal dominant cancer syndrome multiple endocrine neoplasia type 2 (MEN 2). MEN 2 is caused by autosomal dominant gain-of-function mutations in the RET proto-oncogene. In RET-mutation carriers, an age-related progression has been documented from normal C-cells to premalignant C-cell hyperplasia and finally to MTC with or without cervical lymph node metastases. Read More

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http://dx.doi.org/10.1586/eem.10.58DOI Listing
November 2010

Thyroid dysfunction in pregnancy: optimizing fetal and maternal outcomes.

Expert Rev Endocrinol Metab 2010 Jul;5(4):521-529

b Centre for Endocrine and Diabetes Sciences, School of Medicine, Cardiff University, Cardiff CF14 4XN, South Wales, UK.

Recent decades have seen a growing awareness of the threat posed by thyroid dysfunction in pregnancy on maternal, fetal and neonatal well-being. Uncontrolled hypothyroidism and hyperthyroidism are associated with adverse obstetrics and fetal outcomes and also affect neurointellectual development in the offspring. Excellent outcomes are, however, achievable with appropriate management. Read More

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http://dx.doi.org/10.1586/eem.10.30DOI Listing

The role of microRNA-16 in the pathogenesis of autoimmune diseases: A comprehensive review.

Biomed Pharmacother 2019 Feb 16;112:108583. Epub 2019 Feb 16.

Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, Medical College of China Three Gorges University, Yichang, Hubei, 443002, China. Electronic address:

MicroRNAs (miRNAs) are a class of small noncoding RNAs that are only 21-25 nt long. Many studies have shown that miRNA dysfunction is closely related to the occurrence and development of diseases. By combining with the 3' noncoding region of target gene mRNA, miRNAs can mediate the degradation or translation inhibition of mRNA and exert a powerful regulation effect on gene expression at the posttranscriptional level, mainly inhibiting the translation or degradation of targets. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.01.044DOI Listing
February 2019

Clinical management of localized undifferentiated sinonasal carcinoma: our experience and review of the literature.

Anticancer Drugs 2019 Mar;30(3):308-312

Departments of Head and Neck and Sarcoma Oncology.

Undifferentiated sinonasal carcinoma (SNUC) is defined as a small round blue cell tumor that is immunohistochemically distinct from other sinonasal malignancies, such as lymphoma, mucosal melanoma, nasopharyngeal carcinoma, neuroendocrine carcinoma, and olfactory neuroblastoma. SNUCs are very aggressive malignancies, provoking quick destruction of the splanchnocranium structures. Being a very rare neoplasm, there are no prospective clinical trials assessing their treatment strategies, so lots of data are derived by small retrospective trials. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000707DOI Listing

Surgical treatment of rectal cancer with a Retzius shunt: a case report.

Surg Case Rep 2019 Feb 18;5(1):25. Epub 2019 Feb 18.

Department of Surgery, Osaka Rosai Hospital, 1179-3 Nagasonecho, Kita-ku, Sakai, 591-8025, Japan.

Background: A case of a short circuit (Retzius shunt) from the inferior mesenteric vein (IMV) to the inferior vena cava (IVC) without accompanying portal hypertension due to liver cirrhosis is rare.

Case Presentation: An 83-year-old woman who was followed after surgery for thyroid and breast cancer was incidentally found to have rectal cancer on computed tomography (CT). Preoperative three-dimensional CT showed a venous malformation forming a short circuit (Retzius shunt) from the IMV to the IVC. Read More

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http://dx.doi.org/10.1186/s40792-019-0583-zDOI Listing
February 2019

Validation of plasma thyroxine and triiodothyronine methods on the ADVIA Centaur XP.

Scand J Clin Lab Invest 2019 Feb 19:1-7. Epub 2019 Feb 19.

a Department of Clinical Biochemistry, North Zealand Hospital , University of Copenhagen , Hilleroed , Denmark.

Standardization programs for thyroid hormones have revealed bias between immunochemical methods and the reference method ED-ID-LC/MS. Lack of standardization between methods, suboptimal reference intervals and replacement of serum with plasma may compromise the capability of the immunochemical thyroid methods to diagnose thyroid disease. To accommodate the demand for faster turn-around times for laboratory replies, we replaced serum with plasma on some serum CE marked thyroid methods. Read More

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http://dx.doi.org/10.1080/00365513.2019.1571624DOI Listing
February 2019

Changes in bone mineral density and trabecular bone score in Graves' disease patients after anti-thyroid therapy.

Osteoporos Sarcopenia 2016 Sep 21;2(3):175-179. Epub 2016 Jun 21.

Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea.

Objective: The purpose of this study was to evaluate changes in bone quantity based on bone mineral density (BMD) and bone quality based on trabecular bone score (TBS) in Graves' disease patients after anti-thyroid therapy.

Research Design And Method: This retrospective study included premenopausal female and male patients with Graves' disease who received BMD measurement more than two times during treatment. BMD and thyroid function tests with free thyroxine (FT4), total triiodothyronine (T3), thyroid stimulating hormone (TSH), and TSH receptor antibody (TRAb) levels were collected two times during follow-up. Read More

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http://dx.doi.org/10.1016/j.afos.2016.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372732PMC
September 2016

[Discussion about the safety of outpatient thyroid surgery].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Feb;54(2):157-160

Department of Head and Neck Surgery, Sichuan Cancer Hospital Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China.

Thyroid tumors are one of the most common diseases, and the thyroidectomy surgery increases. The outpatient surgery is the new trend in clinic. Is it suited for the thyroidectomy? In this article, we will analyse the setting of hospital, surgeon, surgery, patients, and so on, to prove the safety for the outpatient thyroidectomy. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.02.014DOI Listing
February 2019

On the Etiopathogenesis and Pathophysiology of Alzheimer's Disease: A Comprehensive Theoretical Review.

J Alzheimers Dis 2019 Feb 8. Epub 2019 Feb 8.

Johns Hopkins University.

Alzheimers' disease (AD) is the most common cause of dementia, with an estimated 5 million new cases occurring annually. Among the elderly, AD shortens life expectancy, results in disability, decreases quality of life, and ultimately, leads to institutionalization. Despite extensive research in the last few decades, its heterogeneous pathophysiology and etiopathogenesis have made it difficult to develop an effective treatment and prevention strategy. Read More

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http://dx.doi.org/10.3233/JAD-181052DOI Listing
February 2019

Is the incidence of anaplastic thyroid cancer increasing: A population based epidemiology study.

World J Otorhinolaryngol Head Neck Surg 2019 Mar 11;5(1):34-40. Epub 2018 Aug 11.

Medical University of South Carolina, 135 Rutledge Ave., Charleston, SC., 29425, USA.

Objective: To provide an understanding of the incidence of anaplastic thyroid cancer within the United States.

Methods: Patients in the Surveillance, Epidemiology, and End Results (SEER) database were included from 1973 to 2014 based on a diagnosis of anaplastic thyroid cancer using ICD O-3 codes. Patients were categorized into cohorts based on their year of diagnosis. Read More

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http://dx.doi.org/10.1016/j.wjorl.2018.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364517PMC

Monoclonal Gammopathy of Undetermined Significance-associated Scleromyxoedema.

Indian Dermatol Online J 2019 Jan-Feb;10(1):54-57

Department of Dermatology, Smt. N.H.L Medical College, Ahmedabad, Gujarat, India.

Scleromyxoedema is a rare generalized cutaneous mucinosis, which in absence of thyroid disease, occurs almost invariably in patients with monoclonal gammopathies. A 54-year-old female patient presented with complaint of tightening of skin on the extremities, abdomen, forehead, gradually progressive since 1 year, episodes of generalized tonic-clonic convulsions, and acute psychosis since 5 days. Cutaneous examination revealed nonpitting edema over the face and sclerodermoid changes over extremities. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_138_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362733PMC
February 2019

Integrated Bioinformatics Analysis of Hub Genes and Pathways in Anaplastic Thyroid Carcinomas.

Int J Endocrinol 2019 13;2019:9651380. Epub 2019 Jan 13.

Department of General Surgery, Xuhui District Central Hospital of Shanghai, Shanghai 200031, China.

Anaplastic thyroid carcinoma (ATC) is a very rare malignancy; the pathogenesis of which is still not fully understood. The aim of the present study was to identify hub genes and pathways in ATC by microarray expression profiling. Two independent datasets (GSE27155 and GSE53072) were downloaded from GEO database. Read More

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http://dx.doi.org/10.1155/2019/9651380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350566PMC
January 2019

Gene Variations Confer Susceptibility to Autoimmune Thyroid Diseases and Graves' Ophthalmopathy.

Int J Endocrinol 2019 15;2019:7429187. Epub 2019 Jan 15.

Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, No. 1500 Zhouyuan Road, Pudong District, Shanghai 201318, China.

The objective of this study was to investigate whether polymorphisms are associated with autoimmune thyroid diseases (AITDs). We selected three single nucleotide polymorphisms (SNPs) of , namely, rs1061501, rs1131665, and rs1061502 for genotyping using PCR-based ligase detection reaction (LDR) method in a total of 1659 participants (592 with Graves' disease, 297 with Hashimoto's thyroiditis, and 770 healthy controls). Gene-disease and genotype-clinical phenotype associations were evaluated for the three SNPs. Read More

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http://dx.doi.org/10.1155/2019/7429187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350596PMC
January 2019
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A tribute to Dr. Saul Hertz: The discovery of the medical uses of radioiodine.

Authors:
Barbara Hertz

World J Nucl Med 2019 Jan-Mar;18(1):8-12

Curator, Dr. Saul Hertz Archives and Saul Hertz MD.com.

Dr. Saul Hertz was Director of The Massachusetts General Hospital's Thyroid Unit, when he heard about the development of artificial radioactivity. He conceived and brought from bench to bedside the successful use of radioiodine (RAI) to diagnose and treat thyroid diseases. Read More

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http://dx.doi.org/10.4103/wjnm.WJNM_107_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357704PMC
February 2019

Organic dust inhibits surfactant protein expression by reducing thyroid transcription factor-1 levels in human lung epithelial cells.

Innate Immun 2019 Feb;25(2):118-131

Department of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, USA.

Exposure to organic dust is a risk factor for the development of respiratory diseases. Surfactant proteins (SP) reduce alveolar surface tension and modulate innate immune responses to control lung inflammation. Therefore, changes in SP levels could contribute to the development of organic-dust-induced respiratory diseases. Read More

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http://dx.doi.org/10.1177/1753425919827360DOI Listing
February 2019

Expanding the genetic and clinical spectrum of the NONO-associated X-linked intellectual disability syndrome.

Am J Med Genet A 2019 Feb 17. Epub 2019 Feb 17.

Division of Medical Genetics, University of Utah, Salt Lake City, Utah.

The NONO gene encodes a nuclear protein involved in RNA metabolism. Hemizygous loss-of-function NONO variants have been associated with syndromic intellectual disability and with left ventricular noncompaction (LVNC). A two-year-old boy presented to the University of Utah's Penelope Undiagnosed Disease Program with developmental delay, nonfamilial features, relative macrocephaly, and dilated cardiomyopathy with LVNC and Ebstein anomaly. Read More

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http://dx.doi.org/10.1002/ajmg.a.61091DOI Listing
February 2019
1 Read

[A retrospective analysis of 12 cases of primary thyroid lymphoma].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Feb;51(1):165-170

Department of Endocrinology, Peking University First Hospital, Beijing 100034, China.

Objective: To discuss the clinical characteristics and diagnostic and therapeutic considerations of primary thyroid lymphoma (PTL) by reviewing PTL cases.

Methods: In the study, 12 cases of PTL diagnosed and treated in Peking University First Hospital between January 1995 and September 2015 were identified. The clinical characteristics, management experiences and prognosis of these cases were reviewed retrospectively. Read More

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http://dx.doi.org/10.19723/j.issn.1671-167X.2019.01.028DOI Listing
February 2019

Clinical significance and immunobiology of IL-21 in autoimmunity.

J Autoimmun 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, PR China. Electronic address:

Interleukin-21 (IL-21), an autocrine cytokine predominantly produced by follicular helper T (Tfh) and T helper 17 (Th17) cells, has been proven to play an important role in the immune system, for example, by promoting proliferation and the development of Tfh and Th17 cells, balancing helper T cell subsets, inducing B cell generation and differentiation into plasma cells, and enhancing the production of immunoglobulin. These effects are mainly mediated by activation of the JAK/STAT, MAPK and PI3K pathways. Some IL-21 target genes, such as B lymphocyte induced maturation protein-1 (Blimp-1), suppressor of cytokine signaling (SOCS), CXCR5 and Bcl-6, play important roles in the immune response. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.01.013DOI Listing
February 2019
1 Read

Review: The role of zinc in the endocrine system.

Pak J Pharm Sci 2019 Jan;32(1):231-239

Selcuk University, Medical School, Department of Physiology, Konya, Turkey.

Zinc is essential in the regulation of a variety of physiological and biochemical events in the organism. It plays a critical role in maintaining the cell membrane integrity, protein-carbohydrate-lipid metabolism, immune system, wound injury and in the regulation of a number of other biological processes associated with normal growth and development. Physiological and biochemical levels of many hormones are affected by zinc metabolism. Read More

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January 2019
3 Reads

Sex differences in the association between thyroid-stimulating hormone levels and depressive symptoms among the general population with normal free T4 levels.

J Affect Disord 2019 Feb 10;249:151-158. Epub 2019 Feb 10.

Department of Public Health, Graduate School, Yonsei University, Seoul, Republic of Korea; Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: Overt and subclinical thyroid dysfunction has been reported to be related to depression. Thyroid diseases have been known to occur more frequently in women. However, scarce data are available on effects and sex differences of changes in thyroid-stimulating hormone (TSH) levels, with a normal range of thyroid hormones, on depression. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.027DOI Listing
February 2019

Detection of the sentinel node using a magnetic tracer in thyroid cancer. A technical pilot study.

Cir Esp 2019 Feb 13. Epub 2019 Feb 13.

Departamento de Cirugía, Pediatría y Obstetricia y Ginecología, Universidad de Murcia, Murcia, España; Servicio de Cirugía General y de Aparato Digestivo, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Servicio Murciano de Salud, Murcia, España; Instituto Murciano de Investigación Bio-Sanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, España.

Introduction: There is no standard procedure for the detection of the sentinel node (SN) in thyroid disease. However, the recent detection of the SN using a paramagnetic tracer is proving to be useful in breast cancer and melanoma. The objective was to assess the utility of super paramagnetic iron oxide tracer for the intraoperative detection of the SN in patients with papillary thyroid cancer without nodal involvement in the preoperative study. Read More

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http://dx.doi.org/10.1016/j.ciresp.2018.12.003DOI Listing
February 2019
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Chronic exposure to microcystin-LR reduces thyroid hormone levels by activating p38/MAPK and MEK/ERK signal pathway.

Ecotoxicol Environ Saf 2019 Feb 13;173:142-148. Epub 2019 Feb 13.

Department of Geriatric Endocrinology, Geriatric Hospital of Nanjing Medical University, Luojia Road 30, Nanjing 210024, China. Electronic address:

Microcystin-LR (MC-LR) is the most toxic and abundant microcystin that produced by cyanobacteria. Previous studies have shown MC-LR had acute toxic to thyroid, however, the mechanism is still unclear, and the effect of long-term, low-dose MC-LR on thyroid remains uncertain. In this study, we investigated the chronic, low-dose effect of MC-LR on mouse thyroid tissues and thyroid hormone metabolism. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.02.024DOI Listing
February 2019
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Mathematical models applied to thyroid cancer.

Biophys Rev 2019 Feb 15. Epub 2019 Feb 15.

Instituto de Biociências, Universidade Estadual Paulista (UNESP), Botucatu, SP, 18618-689, Brazil.

Thyroid cancer is the most prevalent endocrine neoplasia in the world. The use of mathematical models on the development of tumors has yielded numerous results in this field and modeling with differential equations is present in many papers on cancer. In order to know the use of mathematical models with differential equations or similar in the study of thyroid cancer, studies since 2006 to date was reviewed. Read More

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http://dx.doi.org/10.1007/s12551-019-00504-7DOI Listing
February 2019
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Association and gene-gene interaction analyses for polymorphic variants in CTLA-4 and FOXP3 genes: role in susceptibility to autoimmune thyroid disease.

Endocrine 2019 Feb 15. Epub 2019 Feb 15.

Department of Genetics, Osmania University, Hyderabad, Telangana, India.

Purpose: Polymorphic variants of cytotoxic T-lymphocyte antigen-4 (CTLA-4) and forkhead box protein P3 (FOXP3) genes are implicated in dysregulated immune homeostasis and autoimmune disorders. We analyzed the association between CTLA-4 rs231775 and FOXP3 rs3761548, rs3761549 polymorphisms and predisposition to autoimmune thyroid disease (AITD), inclusive of Hashimoto's thyroiditis (HT) and Graves' disease (GD) in South-Indian population.

Methods: A total of 355 AITD subjects (comprising 275 HT and 80 GD) and 285 randomly selected age- and sex-matched control subjects were genotyped for the aforementioned polymorphisms by PCR-RFLP method. Read More

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http://dx.doi.org/10.1007/s12020-019-01859-3DOI Listing
February 2019
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How to treat Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

SS is a chronic, autoimmune disease of unknown aetiology for which there is no known curative treatment. Although dryness of the eyes and mouth are the classically described features, patients often experience drying of other mucosal surfaces and systemic manifestations, including fatigue and arthralgia. There is an association with other autoimmune diseases, especially thyroid disease, coeliac disease and primary biliary cholangitis. Read More

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http://dx.doi.org/10.1093/rheumatology/key363DOI Listing
February 2019

Performance of HbA1c versus oral glucose tolerance test (OGTT) as a screening tool to diagnose dysglycemic status in high-risk Thai patients.

BMC Endocr Disord 2019 Feb 15;19(1):23. Epub 2019 Feb 15.

Diabetes and Thyroid Center, Theptarin Hospital, Bangkok, Thailand.

Background: Dysglycemic status defined by prediabetes and diabetes is known to be related with future risk of diabetic complications and cardiovascular diseases. Herein, we aimed to determine the diagnostic accuracy of glycated hemoglobin (HbA1c) when compared with oral glucose tolerance test (OGTT) as a reference test in identifying dysglycemic status among high-risk Thai patients receiving care in an out-patient setting.

Methods: An 11-year retrospective cross-sectional study of high-risk Thai patients who underwent OGTT during 2007-2017 was analysed. Read More

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http://dx.doi.org/10.1186/s12902-019-0339-6DOI Listing
February 2019
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First case report of thyroid abscess caused by Helicobacter cinaedi presenting with thyroid storm.

BMC Infect Dis 2019 Feb 15;19(1):166. Epub 2019 Feb 15.

Division of Pulmonary Medicine, Department of Internal Medicine, Federation of National Public Service Personnel Mutual Aid Associations, Tachikawa Hospital, 4-2-22 Nishikicho, Tachikawa, Tokyo, 190-8531, Japan.

Background: Helicobacter cinaedi is a microaerobic Gram-negative spiral-shaped bacterium that causes enteritis, cellulitis, and bacteremia in both immunocompromised and immunocompetent patients. While there have been increasing numbers of reported H. cinaedi infections recently, there has been no thyroid abscess case caused by H. Read More

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http://dx.doi.org/10.1186/s12879-019-3808-7DOI Listing
February 2019
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Comorbidities (excluding lymphoma) in Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Rheumatology Department, Doctor Negrín University Hospital of Gran Canaria, Gran Canaria, Spain.

The information about comorbidities (excluding lymphoma) in primary Sjögren's syndrome (pSS) is relatively scarce. Cardiovascular disease, infections, musculoskeletal conditions or malignancy are likely the most relevant comorbid conditions in pSS. Different infections (particularly oral candidal infections) and fibromyalgia are extremely frequent in the daily clinical practice. Read More

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http://dx.doi.org/10.1093/rheumatology/key329DOI Listing
February 2019
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Air Pollutants are associated with Dry Eye Disease in Urban Ophthalmic Outpatients: a Prevalence Study in China.

J Transl Med 2019 Feb 15;17(1):46. Epub 2019 Feb 15.

Department of Ophthalmology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No. 301, Yanchang Road, Shanghai, China.

Background: Although previous prevalence studies of DED were reported from some countries worldwide, national data are unavailable in China. We aimed to conduct an up-to-date national survey on the prevalence of DED in China and find out the potential risk factors including air pollutant.

Methods: 23,922 eligible outpatients were recruited from ophthalmic clinics of 32 cities in China in 2013 by registration orders. Read More

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http://dx.doi.org/10.1186/s12967-019-1794-6DOI Listing
February 2019
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3.930 Impact Factor

THE PRIMARY CILIUM IN THE HUMAN THYROCYTE: CHANGES IN FREQUENCY AND LENGTH IN RELATION TO THE FUNCTIONAL PATHOLOGY OF THE THYROID GLAND.

Thyroid 2019 Feb 15. Epub 2019 Feb 15.

School of Medicine. University of Seville, Citología e Histología Normal y Patológica, Seville, Spain ;

Background: Primary cilia (PC) are conserved structures in the adult thyroid gland of different mammals. We have recently described that, in humans, PC are usually present as a single copy per follicular cell emerging from the follicular cell apex into the follicular lumen.

Methods: To better understand the role developed by PC in thyroid hormonogenesis, we investigated their changes in different human functional thyroid diseases (diffuse toxic hyperplasia/Graves' disease and nodular hyperplasia/nodular goiter), in comparison with normal thyroid tissue, using immunofluorescence, morphometry and electron microscopy analyses. Read More

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http://dx.doi.org/10.1089/thy.2018.0401DOI Listing
February 2019
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Alopecia neoplastica as a sign of visceral malignancies: a systematic review.

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio, Emilia, Italy.

Alopecia neoplastica (AN) from visceral tumors is a rare form of cutaneous metastasis in which internal malignancies spread to the scalp. The diagnosis of AN may be very challenging, especially when its onset precedes the diagnosis of the primary tumor. We aimed to improve the knowledge on AN, highlighting that in case of scarring localized alopecia, a differential diagnosis with metastasis should always be considered. Read More

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http://dx.doi.org/10.1111/jdv.15498DOI Listing
February 2019
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Clinico-Pathological Profile of Anaplastic Thyroid Carcinoma in an Endemic Goiter Area.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):793-797

Department of Endocrine Surgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh, India.

Introduction: Anaplastic thyroid cancers (ATCs) usually present in the sixth to seventh decades of life and little is known about the disease in young patients. The aim was to analyze the clinicopathological characteristics diagnosed with ATC in an iodine-deficient area.

Material And Methods: The medical records of 100 patients diagnosed with ATC at a tertiary care hospital between 1991 and 2013 were reviewed. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_264_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330874PMC
February 2019
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