7,743 results match your criteria Thyroid Cancer in Children


MicroRNA-4500 Inhibits Migration, Invasion, and Angiogenesis of Breast Cancer Cells via RRM2-Dependent MAPK Signaling Pathway.

Mol Ther Nucleic Acids 2020 May 4;21:278-289. Epub 2020 May 4.

Department of Breast Surgery, Shenzhen Maternity and Child Health Hospital, Shenzhen 518000, P.R. China.

With the consideration of the dynamic role of microRNAs (miRNAs) in breast cancer, miRNAs may serve as therapeutic targets, helping to prevent development of therapy resistance, maintain stable disease, and prohibit metastatic spread. We identified the differentially expressed breast cancer-related gene ribonucleotide reductase subunit M2 (RRM2) as the study focus through microarray expression profiles. Next, the upstream regulatory microRNA (miR)-4500 of RRM2 was predicted using bioinformatics website analysis, and their binding was verified by a dual luciferase reporter gene assay. Read More

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http://dx.doi.org/10.1016/j.omtn.2020.04.018DOI Listing

Targeted Oncogene Therapy Before Surgery in Pediatric Patients With Advanced Invasive Thyroid Cancer at Initial Presentation: Is It Time for a Paradigm Shift?

JAMA Otolaryngol Head Neck Surg 2020 Jul 2. Epub 2020 Jul 2.

Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Importance: Initial data suggest the effectiveness of oncogene-specific targeted therapies in inducing tumor regression of diverse cancers in children and adults, with minimal adverse effects.

Observations: In this review, preliminary data suggest that systemic therapy may be effective in inducing tumor regression in pediatric patients with unresectable invasive thyroid cancer. Although most pediatric patients with thyroid cancer initially present with operable disease, some children have extensive disease that poses substantial surgical challenges and exposes them to higher than usual risk of operative complications. Read More

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http://dx.doi.org/10.1001/jamaoto.2020.1340DOI Listing

Hurthle cell carcinoma in childhood: A retrospective analysis of five cases and review of pediatric literature.

Pediatr Blood Cancer 2020 Jul 2:e28300. Epub 2020 Jul 2.

Division of Pediatrics, Department of Human Pathology in Adulthood and Childhood, University of Messina, Messina, Italy.

Background: the available studies on Hurthle cell carcinoma (HCC) in pediatric age are scarce and based on isolated case reports. Aims of the present study were to review the available pediatric literature on HCC (2000-2019), to describe the cohort of children with this cancer histotype, and to estimate its relative prevalence in pediatric age.

Procedure: We retrospectively reconstructed an HCC course in five patients < 19 years who were identified in our departments during the period 2000-2019, and we reviewed the available pediatric studies on this differentiated thyroid cancer (DTC) variant. Read More

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http://dx.doi.org/10.1002/pbc.28300DOI Listing

Cumulative evidence of relationships between multiple variants in 8q24 region and cancer incidence.

Medicine (Baltimore) 2020 Jun;99(26):e20716

Department of Pediatrics.

Genome-wide association studies (GWAS) have identified multiple independent cancer susceptibility loci at chromosome 8q24. We aimed to evaluate the associations between variants in the 8q24 region and cancer susceptibility. A comprehensive research synopsis and meta-analysis was performed to evaluate associations between 28 variants in 8q24 and risk of 7 cancers using data from 103 eligible articles totaling 146,932 cancer cases and 219,724 controls. Read More

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http://dx.doi.org/10.1097/MD.0000000000020716DOI Listing

KIF15 contributes to cell proliferation and migration in breast cancer.

Hum Cell 2020 Jun 23. Epub 2020 Jun 23.

Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215006, China.

A number of kinesin proteins (KIFs) have been implicated in the development of multiple cancers. However, little is known about the expression and function of KIF15 in human breast cancer. Herein, we detected KIF15 expression in breast cancer tissues and paired adjacent normal tissues using immunohistochemistry and quantitative real-time polymerase chain reaction analysis, and the correlation of KIF15 expression with clinicopathological parameters was evaluated statistically. Read More

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http://dx.doi.org/10.1007/s13577-020-00392-0DOI Listing

Medullary Thyroid Carcinoma in Children.

Semin Pediatr Surg 2020 Jun 16;29(3):150921. Epub 2020 May 16.

Department of Surgery, Endocrine Surgery Section, University of California, San Francisco. Electronic address:

The vast majority of medullary thyroid carcinomas (MTC) in children are inherited as part of the multiple endocrine neoplasia (MEN) syndromes MEN2A and MEN2B, and the related variant, familial MTC. Prophylactic surgery in infants and children identified through genetic screening leads to the highest survival in these patients. This article summarizes the current recommendations for screening, treatment, and surveillance of children with MTC to provide a concise clinically relevant review for pediatric practitioners. Read More

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http://dx.doi.org/10.1016/j.sempedsurg.2020.150921DOI Listing

Papillary and Follicular Thyroid Cancer in children and adolescents: Current approach and future directions.

Authors:
Andrew J Bauer

Semin Pediatr Surg 2020 Jun 16;29(3):150920. Epub 2020 May 16.

The Thyroid Center, Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, 3500 Civic Center Boulevard, Buerger Center, 12-149, Philadelphia, PA USA 19104; Department of Pediatrics, The Perelman School of Medicine, The University of Pennsylvania, 415 Curie Blvd, Philadelphia, PA USA 19104. Electronic address:

An increasing number of children are diagnosed with differentiated thyroid cancer. With an excellent prognosis for the majority of pediatric patients, the goal of therapy is to optimize outcome while reducing complications. Increased knowledge of the somatic, oncogenic driver mutations provides opportunities to improve the accuracy of diagnosis, to stratify surgery, and to treat patients with morbidly invasive or refractory disease. Read More

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http://dx.doi.org/10.1016/j.sempedsurg.2020.150920DOI Listing

Practice Patterns and Outcomes of Pediatric Thyroid Surgery: An NSQIP Analysis.

J Surg Res 2020 Jun 18;255:181-187. Epub 2020 Jun 18.

Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa. Electronic address:

Background: Pediatric thyroid cancer rates are rising. The aim of this study was to determine the state of current practice and outcomes for pediatric thyroidectomies using the pediatric National Surgical Quality Improvement Program (NSQIP-P) with specific attention to differences based on surgeon type/specialty.

Methods: All cases of pediatric thyroidectomies and neck dissections within the NSQIP-P database were identified from 2015 to 2017. Read More

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http://dx.doi.org/10.1016/j.jss.2020.05.056DOI Listing
June 2020
1.936 Impact Factor

Should Total Thyroidectomy Be Recommended for Patients with Familial Non-medullary Thyroid Cancer?

World J Surg 2020 Jun 18. Epub 2020 Jun 18.

Department of Endocrinology, Ulsan University Hospital, University of Ulsan College of Medicine, 877, Bangeojinsunhwando-ro, Dong-gu, Ulsan, 44033, South Korea.

Background: It is unknown whether familial non-medullary thyroid cancer (FNMTC) has more aggressive clinical features and a worse prognosis than sporadic non-medullary thyroid cancer (SNMTC).

Methods: We retrospectively reviewed 2894 patients with differentiated thyroid cancer who underwent primary thyroidectomy, identified 391 FNMTC cases, and compared the prevalence, surgical extension, and clinicopathologic features of FNMTC and SNMTC.

Results: A family history of thyroid cancer was noted in 391 patients (13. Read More

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http://dx.doi.org/10.1007/s00268-020-05473-7DOI Listing

Eruptive Halo Naevi: A Possible Indicator of Malignant Disease in a Case Series of Post-Adolescent Patients.

Acta Derm Venereol 2020 Jun 16. Epub 2020 Jun 16.

Department of Dermatology, Aarhus University Hospital, DK-8200 Aarhus N, Denmark. E-mail:

Halo naevi are considered benign. They occur in children and adolescents. Eruptive multiple halo naevi are infrequently seen in adults. Read More

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http://dx.doi.org/10.2340/00015555-3568DOI Listing

Pediatric differentiated thyroid carcinoma: An update from the APSA Cancer Committee.

J Pediatr Surg 2020 May 11. Epub 2020 May 11.

Department of Surgery, Boys Town National Research Hospital, Omaha, NE.

Background: Differentiated thyroid carcinomas (DTCs) are rare in young children but represent almost 10% of all malignancies diagnosed in older adolescents.

Methods: This article reviews the recent literature describing surgical therapeutic approaches to pediatric DTC, associated complications, and long-term recurrence and survival outcomes.

Results: Similar to adult thyroid cancers, pediatric DTCs are more common in females and are associated with thyroid nodules, family history of thyroid cancer, radiation exposure, iodine deficiency, autoimmune thyroid disease, and genetic syndromes. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2020.05.003DOI Listing

Low Bone Mineral Density at Initial Diagnosis in Children and Adolescents with Graves' Disease.

J Clin Densitom 2020 May 21. Epub 2020 May 21.

Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, Suwon, Republic of Korea. Electronic address:

Previous studies have reported reduced bone mineral density (BMD) in patients with hyperthyroidism. We assessed the association of BMD in children and adolescents with Graves' disease (GD) after correcting for potential confounders affecting BMD such as age, sex, and pubertal status. Forty-four children and adolescents with GD and 172 age- and sex-matched healthy controls were enrolled in this study. Read More

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http://dx.doi.org/10.1016/j.jocd.2020.05.006DOI Listing

Long-term outcome of differentiated thyroid cancer in children and young adults: risk stratification by ATA criteria and assessment of pre-ablation stimulated thyroglobulin as predictors of disease persistence.

Endocrine 2020 Jun 13. Epub 2020 Jun 13.

Department of Endocrinology, Diabetes and Metabolism, Evangelismos Hospital, 10676, Athens, Greece.

Purpose: Differentiated thyroid cancer (DTC) has an increasing incidence in childhood and adolescence but long-term outcome data are limited. We aimed to identify possible risk factors associated with disease persistence, with special focus on the usefulness of ATA risk stratification system and pre-ablation stimulated thyroglobulin (Tg) levels.

Methods: We retrospectively studied 103 patients, 79 females (76. Read More

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http://dx.doi.org/10.1007/s12020-020-02378-2DOI Listing

Demonstration of reciprocal diurnal variation in human serum T3 and rT3 concentration demonstrated by mass spectrometric analysis and establishment of thyroid hormone reference intervals.

Ther Adv Endocrinol Metab 2020 27;11:2042018820922688. Epub 2020 May 27.

Department of Laboratory Medicine, Clinical Center, National Institutes of Health, 10 Center Drive, Building 10, Office:2C429, Bethesda, MD 20892-0001, USA.

Background: There has been a wide range of reference intervals proposed in previous literature for thyroid hormones due to large between-assay variability of immunoassays, as well as lack of correction for collection time. We provided the diurnal reference intervals for five thyroid hormones, namely total thyroxine (TT4), total triiodothyronine (TT3), free thyroxine (FT4), free triiodothyronine (FT3), and reverse T3 (rT3), measured in serum samples of healthy participants using a liquid chromatography/tandem mass spectrometry (LC-MS/MS) method.

Methods: Couplet serum samples (a. Read More

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http://dx.doi.org/10.1177/2042018820922688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257839PMC

Misunderstanding of the purpose and intermediate results of the Fukushima health management survey could impede the progress in the radiation protection field.

J Radiol Prot 2020 Jun 10. Epub 2020 Jun 10.

Department of Public Health, Fukushima Medical University School of Medicine, Fukushima, 960-1295, JAPAN.

After Fukushima Daiichi Nuclear Power Plant (FDNPP) incident, ultrasound screening of the thyroid gland was conducted for children under 18 years of age as part of the Fukushima Health Management Survey (FHMS) designed to assess and protect the residents' health. However, several studies were conducted with a misunderstanding of the purpose of the FHMS and the characteristics of FHMS data. This letter highlight is to point out some crucial troubling aspect of these publications. Read More

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http://dx.doi.org/10.1088/1361-6498/ab9b65DOI Listing

Increasing incidence of cancer and stage migration towards advanced disease in children and young adolescents in the Netherlands, 1990-2017.

Eur J Cancer 2020 Jul 7;134:115-126. Epub 2020 Jun 7.

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands; Department of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands. Electronic address:

Background: This is the first national study on trends in cancer incidence for children and young adolescents in the Netherlands, including stage at diagnosis as a potential marker of early diagnosis and better staging.

Methods: All neoplasms in patients younger than 18 years, diagnosed between 1990 and 2017 (N = 15,233), were derived from the Netherlands Cancer Registry. Incidence rates and the average annual percentage change with 95% CIs were calculated for all cancers combined and diagnostic (sub)groups. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.04.011DOI Listing

Overdiagnosis of Juvenile Thyroid Cancer.

Authors:
Toru Takano

Eur Thyroid J 2020 May 16;9(3):124-131. Epub 2019 Oct 16.

Rinku General Medical Center, Izumisano, Japan.

Overdiagnosis is the detection of a disease that does not do any harm to the patient throughout the lifetime. Thyroid cancer in children is a rare disease; however, since 2011, many children in Fukushima, Japan, have been diagnosed with it, and the number has shown a steady increase to over 200 cases at present. Some experts have stated that this phenomenon is due to overdiagnosis caused by thyroid ultrasound (US)-based thyroid screening detecting self-limiting thyroid cancer, which will not lead to clinical symptoms in the future. Read More

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http://dx.doi.org/10.1159/000503323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265730PMC

Lung metastasis in children with differentiated thyroid cancer: factors associated with diagnosis and outcomes of therapy.

Thyroid 2020 Jun 10. Epub 2020 Jun 10.

Hospital for Sick Children, 7979, Division of Endocrinology, Toronto, Ontario, Canada;

Background: Lung metastasis from differentiated thyroid cancer (DTC) in children and young adults (CAYA) is estimated at 25%, which is 3-4 times higher than in adults. Lung metastasis can respond to radioactive iodine (RAI) therapy and overall survival is excellent. Associations with lung metastasis include lateral lymph node (LN) disease although CAYA data are limited. Read More

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http://dx.doi.org/10.1089/thy.2020.0002DOI Listing

T1 Glottic Cancer: Does Anterior Commissure Involvement Worsen Prognosis?

Cancers (Basel) 2020 Jun 6;12(6). Epub 2020 Jun 6.

Department of Otorhinolaryngology, Maxillofacial and Thyroid Surgery, Fondazione IRCCS, National Cancer Institute of Milan, University of Milan, 20122 Milan, Italy.

Radiotherapy (RT) and transoral laser microsurgery (TLM) represent the main treatment modalities for early glottic carcinoma. Local failure is notoriously more frequent in T1b glottic cancer in comparison to T1a and T2 tumors. In this scenario, the role of anterior commissure (AC) involvement is still controversial. Read More

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http://dx.doi.org/10.3390/cancers12061485DOI Listing

Malignant teratoid tumor of the thyroid gland: an aggressive primitive multiphenotypic malignancy showing organotypical elements and frequent DICER1 alterations-is the term "thyroblastoma" more appropriate?

Virchows Arch 2020 Jun 7. Epub 2020 Jun 7.

Instituto de Investigação e Inovação em Saúde, Porto, Portugal.

Primary thyroid teratomas are exceedingly rare. Mature and immature variants recapitulate their gonadal counterparts (predilection for infants/children, triphasic germ layer differentiation, and favorable outcome). On the other hand, the so-called malignant teratomas affect predominantly adults and elderly, are highly aggressive, and, according to a few published cases, harbor DICER1 mutations. Read More

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http://dx.doi.org/10.1007/s00428-020-02853-1DOI Listing

Risk of second primary breast cancer among cancer survivors: Implications for prevention and screening practice.

PLoS One 2020 4;15(6):e0232800. Epub 2020 Jun 4.

Department of Epidemiology and Biostatistics, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Second primary breast cancer (SPBC) is becoming one of the major obstacles to breast cancer (BC) control. This study was aimed to determine the trend of SPBC incidence over time and the risk of developing SPBC in site-specific primary cancer survivors in the United States. The Surveillance, Epidemiology, and End Results (SEER) 13 registry (1992-2015) was used to identify SPBC patients with previous malignancies. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232800PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272050PMC

Accuracy of CEUS-guided sentinel lymph node biopsy in early-stage breast cancer: a study review and meta-analysis.

World J Surg Oncol 2020 May 29;18(1):112. Epub 2020 May 29.

Department of Thyroid and Breast Surgery, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China.

Objective: To investigate whether preoperative localization of sentinel lymph node (SLN) by contrast-enhanced ultrasound (CEUS) can further improve the accuracy of sentinel lymph node biopsy (SLNB).

Method: Collect published literatures or conference reports by searching electronic databases. The Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) evaluation method is used to evaluate the quality of the screened literatures. Read More

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http://dx.doi.org/10.1186/s12957-020-01890-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260746PMC

EV PD-L1 is correlated with clinical features and contributes to T cell suppression in pediatric thyroid cancer.

J Clin Endocrinol Metab 2020 May 27. Epub 2020 May 27.

Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, China.

Context: The contribution of blood extracellular vesicular (EV) programmed death-ligand 1 (PD-L1) and programmed death-1 (PD-1) in papillary thyroid cancer (PTC) is uncertain.

Objective: We sought to determine the relationship of EV PD-L1/PD-1 with the clinical features of pediatric PTC and the role of EV PD-L1 in immunosuppression.

Main Outcome Measures: Plasma levels of EV and soluble PD-L1 and PD-1 and levels of plasma cytokines in PTC children and controls were determined by ELISA. Read More

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http://dx.doi.org/10.1210/clinem/dgaa309DOI Listing

YAP confers resistance to vandetanib in medullary thyroid cancer.

Biochem Cell Biol 2020 Jun 25;98(3):443-448. Epub 2020 May 25.

Department of General Surgery, Jiaxing Maternity and Child Health Care Hospital, No. 2468 Central East Road, Nanhu District, Jiaxing 314000, Zhejiang, China.

Medullary thyroid cancer (MTC) is the third most common thyroid cancer. (Rearranged in Transformation) gene mutations are considered as one of the major drivers of MTC. Vandetanib suppresses RET activity, and has shown promise in clinical trials. Read More

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http://dx.doi.org/10.1139/bcb-2019-0354DOI Listing

Presentation and outcome of subsequent thyroid cancer among childhood cancer survivors compared to sporadic thyroid cancer: a matched national study.

Eur J Endocrinol 2020 Aug;183(2):169-180

Department of Pediatric Endocrinology, Wilhelmina Children's Hospital/University Medical Center Utrecht, Utrecht, The Netherlands.

Objective: Childhood cancer survivors (CCS) are at increased risk to develop differentiated thyroid cancer predominantly after radiotherapy (subsequent DTC). It is insufficiently known whether subsequent DTC in CCS has a different presentation or outcome than sporadic DTC.

Methods: Patients with subsequent DTC (n = 31) were matched to patients with sporadic DTC (n = 93) on gender, age and year of diagnosis to compare presentation and DTC outcomes. Read More

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http://dx.doi.org/10.1530/EJE-20-0153DOI Listing

Association of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis.

Lancet Diabetes Endocrinol 2020 Jun;8(6):501-510

Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands; Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, Netherlands. Electronic address:

Background: Adequate transplacental passage of maternal thyroid hormone is important for normal fetal growth and development. Maternal overt hypothyroidism and hyperthyroidism are associated with low birthweight, but important knowledge gaps remain regarding the effect of subclinical thyroid function test abnormalities on birthweight-both in general and during the late second and third trimester of pregnancy. The aim of this study was to examine associations of maternal thyroid function with birthweight. Read More

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http://dx.doi.org/10.1016/S2213-8587(20)30061-9DOI Listing

Ovarian Sertoli-Leydig cell tumors: an analysis of 13 cases.

Arch Gynecol Obstet 2020 Jul 19;302(1):203-208. Epub 2020 May 19.

International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Purpose: To report the clinical, ultrasound and histopathological characteristics, clinical management, and prognosis of 13 patients with Sertoli-Leydig cell tumors (SLCTs) of ovary.

Methods: 13 patients with pathologically confirmed ovarian SLCTs at International Peace Maternity and Child Health Hospital from 2010 and 2019 were included in this study. The clinical, ultrasound and histopathological characteristics, clinical management, and prognosis of 13 patients were retrospectively analyzed. Read More

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http://dx.doi.org/10.1007/s00404-020-05588-1DOI Listing

Pleuropulmonary blastoma-like peritoneal sarcoma: a newly described malignancy associated with biallelic DICER1 pathogenic variation.

Mod Pathol 2020 May 15. Epub 2020 May 15.

International Pleuropulmonary Blastoma/DICER1 Registry, Children's Minnesota, Minneapolis, MN, USA.

Since the original description of pathogenic germline DICER1 variation underlying pleuropulmonary blastoma (PPB), the spectrum of extrapulmonary neoplasms known to be associated with DICER1 has continued to expand and now includes tumors of the ovary, thyroid, kidney, eye, and brain among other sites. This report documents our experience with another manifestation: a primitive sarcoma that resembles PPB and DICER1-associated sarcoma of the kidney. These tumors are distinguished by their unusual location in the peritoneal cavity, associated with visceral and/or parietal mesothelium. Read More

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http://dx.doi.org/10.1038/s41379-020-0558-4DOI Listing

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.

Cell 2020 05 27;181(5):1016-1035.e19. Epub 2020 Apr 27.

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Program in Immunology, Harvard Medical School, Boston, MA 02115, USA; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-CoV-2 spike (S) protein binds angiotensin-converting enzyme 2 (ACE2), and in concert with host proteases, principally transmembrane serine protease 2 (TMPRSS2), promotes cellular entry. The cell subsets targeted by SARS-CoV-2 in host tissues and the factors that regulate ACE2 expression remain unknown. Read More

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http://dx.doi.org/10.1016/j.cell.2020.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252096PMC

Cancer Among Adolescents and Young Adults Between 2000 and 2016 in France: Incidence and Improved Survival.

J Adolesc Young Adult Oncol 2020 May 15. Epub 2020 May 15.

Registre National des Cancers de l'Enfant, Registre National des Tumeurs Solides de l'Enfant, CHRU Nancy, Vandœuvre-lès-Nancy, France.

This study was undertaken to determine cancer survival and describe the spectrum of cancers diagnosed among French adolescent and young adult (AYA) population. All cases of cancer diagnosed in 15-24 years, recorded by all French population-based registries (18% of the French population), over the 2000-2016 period, were included. Age-standardized incidence rates, conventional annual percentage change (cAPC) of incidence over time, and 5-year overall survival (5yOS) were calculated. Read More

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http://dx.doi.org/10.1089/jayao.2020.0017DOI Listing

Subsequent neoplasms and late mortality in children undergoing allogeneic transplantation for nonmalignant diseases.

Blood Adv 2020 May;4(9):2084-2094

Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Department of Pediatrics, Columbia University, New York, NY.

We examined the risk of subsequent neoplasms (SNs) and late mortality in children and adolescents undergoing allogeneic hematopoietic cell transplantation (HCT) for nonmalignant diseases (NMDs). We included 6028 patients (median age, 6 years; interquartile range, 1-11; range, <1 to 20) from the Center for International Blood and Marrow Transplant Research (1995-2012) registry. Standardized mortality ratios (SMRs) in 2-year survivors and standardized incidence ratios (SIRs) were calculated to compare mortality and SN rates with expected rates in the general population. Read More

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http://dx.doi.org/10.1182/bloodadvances.2019000839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218429PMC

A Novel Multimodal Therapy for Anaplastic Thyroid Carcinoma: I Seed Implantation Plus Apatinib After Surgery.

Front Endocrinol (Lausanne) 2020 22;11:207. Epub 2020 Apr 22.

Department of Thyroid-breast-hernia Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Anaplastic thyroid cancer is known to be the most lethal malignancy among endocrine tumors for its extremely limited survival rate after diagnosis. As a result of this poor survival prognosis, multimodal therapy is currently under investigation to address this global concern. In this reported case, the I seed implantation and vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor apatinib were co-applied to treat a 49-year-old woman with anaplastic thyroid cancer. Read More

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http://dx.doi.org/10.3389/fendo.2020.00207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188788PMC

Thyroid carcinoma in children, adolescents, and young adults in Brazil: A report from 11 population-based cancer registries.

PLoS One 2020 1;15(5):e0232416. Epub 2020 May 1.

Research Center, Instituto Nacional de Cancer, Rio de Janeiro, RJ, Brazil.

Background: The increasing incidence of thyroid cancer has been described worldwide. Overdiagnosis, improved imaging, and increased environmental risk factors have contributed to the rising incidence. The objective of this study was to analyze the population incidence rate and trends during the period of 2000-2013 in children, adolescents and young adults (AYAs) in Brazil. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232416PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194432PMC

Bilateral pulmonary metastases of papillary thyroid carcinoma in a 12-year-old child-A case report and review of the literature.

Radiol Case Rep 2020 Jun 21;15(6):799-802. Epub 2020 Apr 21.

Ameripath Lubbock Pathology, Ameripath, Lubbock, TX 79407, USA.

Metastatic disease of the lung has been extensively documented in the adult patient population. The most common primary sources for pulmonary metastases include breast, colon gastrointestinal including pancreas and urinary bladder. Malignant lung tumors in pediatric population is extremely rare. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178319PMC

Spectrum of PALB2 germline mutations and characteristics of PALB2-related breast cancer: Screening of 16,501 unselected patients with breast cancer and 5890 controls by next-generation sequencing.

Cancer 2020 Jul 27;126(14):3202-3208. Epub 2020 Apr 27.

Department of Breast Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: Partner and localizer BRCA2 (PALB2) is a breast cancer predisposition gene, but the clinical relevance of PALB2 germline mutations in Chinese patients with breast cancer remains unknown. This study attempted to investigate the full prevalence and spectrum of PALB2 germline mutations in China and the associations between PALB2 germline mutations and breast cancer risk.

Methods: A total of 21,216 unselected patients with breast cancer were enrolled from 10 provinces in China, and 5890 Chinese women without cancer were enrolled as healthy controls. Read More

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http://dx.doi.org/10.1002/cncr.32905DOI Listing

Deletion of Suppresses the Malignant Phenotypes of Breast Cancer Cells and Through Targeting Axis.

Cancer Biother Radiopharm 2020 Apr 22. Epub 2020 Apr 22.

Department of Thyroid Breast and Vascular Surgery, First Affiliated Hospital of Air Force Military Medical University, Xi'an, Shaanxi, China.

Hepatocyte nuclear factor 1 homeobox A-antisense RNA 1 () is a long noncoding RNA and controls human tumor development and progression. However, its expression and role in breast cancer, the most overwhelmingly occurring malignancy in women globally, remain poorly illuminated. Expression of , ()-, and tripartite motif containing 32 () was detected using quantitative real-time polymerase chain reaction and western blotting. Read More

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http://dx.doi.org/10.1089/cbr.2019.3168DOI Listing

A nationwide questionnaire survey targeting Japanese pediatric endocrinologists regarding transitional care in childhood, adolescent, and young adult cancer survivors.

Clin Pediatr Endocrinol 2020 16;29(2):55-62. Epub 2020 Apr 16.

Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan.

Existing guidelines recommend long-term follow-up of childhood cancer survivors (CCS). However, in Japan, transitional care for CCS has not been established. To ascertain the current status in Japan, and to cultivate a better understanding, a questionnaire survey was conducted on transitional care in CCS, and adolescent and young adult (AYA) cancer survivors. Read More

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http://dx.doi.org/10.1297/cpe.29.55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160455PMC

LncRNA WEE2-AS1 promotes proliferation and inhibits apoptosis in triple negative breast cancer cells via regulating miR-32-5p/TOB1 axis.

Biochem Biophys Res Commun 2020 Jun 16;526(4):1005-1012. Epub 2020 Apr 16.

Prenatal Diagnosis Center, Hubei Maternal and Child Health Hospital, Wuhan, 430070, Hubei, China.

Triple negative breast cancer (TNBC) is a malignant breast cancer subtype with poor prognosis. Recent studies have revealed the critical roles of dysregulated long non-coding RNAs (lncRNAs) in many cancer types, including TNBC. LncRNA WEE2 antisense RNA 1 (WEE2-AS1) has been reported to be able to promote the progression of hepatocellular carcinoma, but the function of WEE2-AS1 in TNBC is still unknown. Read More

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http://dx.doi.org/10.1016/j.bbrc.2020.01.170DOI Listing

[Clinical pathology and incidence trend of thyroid cancer based on 21 980 cases].

Zhonghua Yi Xue Za Zhi 2020 Apr;100(14):1072-1076

Department of Thyroid Surgery, the First Affiliated Hospital of Zhengzhou University, Key-Discipline Laboratory Clinical Medicine for Colleges and Universities in Henan, Zhengzhou 450052, China.

To analyze the clinical pathological characteristics and incidence of thyroid cancer. The clinical and pathological data of 21 980 thyroid cancer patients who underwent surgery in the Department of Thyroid Surgery of the First Affiliated Hospital of Zhengzhou University from January 2012 to December 2018, including the gender, age, pathological type, tumor size, tumor number, central and lateral lymph node metastasis, was retrospectively analyzed. There were 16 895 females and 5 085 males (gender ratio: 3. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20190905-01972DOI Listing

Osseous metaplasia of the thyroid cancer.

Endokrynol Pol 2020 Apr 15. Epub 2020 Apr 15.

Papillary carcinoma is the most frequently occurring thyroid cancer among both children and adults which may occur at any age. Exposition to the ionizing radiation is the main risk factor. Papillary carcinoma may be indicated by the painless tumor, which is hormonally inactive. Read More

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http://dx.doi.org/10.5603/EP.a2020.0018DOI Listing

Outpatient thyroidectomy in the pediatric population.

Am J Surg 2020 06 2;219(6):890-893. Epub 2020 Apr 2.

University of Alabama at Birmingham, Department of Surgery, 1808 7th Ave S, Boshell Diabetes Building, Birmingham, AL, 35233, USA. Electronic address:

Preoperative optimization and patient education have allowed for the transition of thyroid surgery to the outpatient setting over the last few decades. Performing these operations in the outpatient setting has proven to be cost-effective and safe in the adult population. The purpose of this study is to evaluate the safety and efficacy of outpatient thyroid surgery in the pediatric population. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.03.025DOI Listing

Management of pediatric differentiated thyroid cancer: An overview for the pediatric oncologist.

Pediatr Blood Cancer 2020 Jun 10;67(6):e28141. Epub 2020 Apr 10.

Division of Hematology/Oncology, Department of Pediatrics, Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.

Differentiated thyroid cancer (DTC) is the most common childhood thyroid malignancy. The standard of care for pediatric DTC is total thyroidectomy followed by radioactive iodine (RAI) treatment when indicated. Molecular changes and potential therapeutic targets have been recently described in pediatric thyroid cancer. Read More

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http://dx.doi.org/10.1002/pbc.28141DOI Listing
June 2020
2.562 Impact Factor

Pulmonary and overall healthcare utilization after childhood and young adult thyroid cancer.

Endocr Relat Cancer 2020 Jun;27(6):391-402

Pediatric Oncology Group of Ontario, Toronto, Ontario, Canada.

Differentiated thyroid carcinoma (DTC) in children, adolescents, and young adults is associated with excellent prognosis. However, little is known about the long-term utilization of healthcare resources among survivors. The objective of this study was to compare the utilization of healthcare resources among DTC survivors to the general population, with a focus on pulmonary-related resource utilization. Read More

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http://dx.doi.org/10.1530/ERC-19-0463DOI Listing

Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications.

J Hepatol 2020 Mar 30. Epub 2020 Mar 30.

Childhood Liver Oncology Group, Germans Trias i Pujol Research Institute (IGTP), Program for Predictive and Personalized Medicine of Cancer (PMPPC), Badalona, Spain; CIBER, Hepatic and Digestive Diseases, Barcelona, Spain. Electronic address:

Background & Aims: Hepatoblastoma (HB) is a rare disease. Nevertheless, it is the predominant pediatric liver cancer, with limited therapeutic options for patients with aggressive tumors. Herein, we aimed to uncover the mechanisms of HB pathobiology and to identify new biomarkers and therapeutic targets in a move towards precision medicine for patients with advanced HB. Read More

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http://dx.doi.org/10.1016/j.jhep.2020.03.025DOI Listing

Postoperative Hypoparathyroidism After Total Thyroidectomy in Children.

J Surg Res 2020 Aug 29;252:63-68. Epub 2020 Mar 29.

Department of Surgery, University of California San Francisco, San Francisco, California. Electronic address:

Background: Postoperative hypocalcemia because of hypoparathyroidism is the most common complication of total thyroidectomy in children. We hypothesized that most children with postoperative hypocalcemia would be eucalcemic by 12 mo and sought to define risk factors for permanent hypoparathyroidism.

Methods: We retrospectively reviewed children who underwent total thyroidectomy at a single children's hospital from 2012 to 2019. Read More

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http://dx.doi.org/10.1016/j.jss.2020.02.018DOI Listing

Predominant Pathogenic Variants in Pediatric Follicular Thyroid Carcinomas.

Thyroid 2020 May 8. Epub 2020 May 8.

Seoul National University Cancer Research Institute, Seoul Republic of Korea.

Pediatric thyroid cancer has characteristics that are distinct from adulthood thyroid cancer. Due to its very low prevalence, little is known about the genetic characteristics of pediatric follicular thyroid cancer (FTC). We investigated genetic alterations in tumor tissues from 15 patients aged <20 years (median: 14. Read More

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http://dx.doi.org/10.1089/thy.2019.0233DOI Listing

Impact of maternal reproductive factors on cancer risks of offspring: A systematic review and meta-analysis of cohort studies.

PLoS One 2020 30;15(3):e0230721. Epub 2020 Mar 30.

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.

Background: A number of studies have reported on associations between reproductive factors, such as delivery methods, number of birth and breastfeeding, and incidence of cancer in children, but systematic reviews addressing this issue to date have important limitations, and no reviews have addressed the impact of reproductive factors on cancer over the full life course of offspring.

Methods: We performed a comprehensive search in MEDLINE, and Embase up to January 2020 and Web of Science up to 2018 July, including cohort studies reporting the association between maternal reproductive factors of age at birth, birth order, number of births, delivery methods, and breastfeeding duration and cancer in children. Teams of two reviewers independently extracted data and assessed risk of bias. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230721PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105118PMC

Assessment of Thyroid Function in Patients With Alkaptonuria.

JAMA Netw Open 2020 Mar 2;3(3):e201357. Epub 2020 Mar 2.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.

Importance: Alkaptonuria is an autosomal recessive disorder caused by pathogenic variants in the HGD gene. Deficiency of the HGD enzyme leads to tissue deposition of homogentisic acid (HGA), causing severe osteoarthropathies and cardiac valve degeneration. Although HGD is vital for the catabolism of tyrosine, which provides the basis for thyroid hormone synthesis, the prevalence of thyroid dysfunction in alkaptonuria is unknown. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.1357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090965PMC