58,399 results match your criteria Thyroid Anatomy


An exonic splicing enhancer mutation in causes aberrant alternative splicing and severe congenital hypothyroidism in Bama pigs.

Dis Model Mech 2019 Jan 15;12(1). Epub 2019 Jan 15.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, China

Pigs share many similarities with humans in terms of anatomy, physiology and genetics, and have long been recognized as important experimental animals in biomedical research. Using an N-ethyl-N-nitrosourea (ENU) mutagenesis screen, we previously identified a large number of pig mutants, which could be further established as human disease models. However, the identification of causative mutations in large animals with great heterogeneity remains a challenging endeavor. Read More

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http://dmm.biologists.org/lookup/doi/10.1242/dmm.036616
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http://dx.doi.org/10.1242/dmm.036616DOI Listing
January 2019
1 Read

Bilateral thyrolinguofacial trunk: unusual and rare branching pattern of external carotid artery.

Anat Cell Biol 2018 Dec 29;51(4):302-304. Epub 2018 Dec 29.

Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India.

Prior knowledge of arterial supply to the head and neck is of substantial importance for well-planned surgeries involving the concerned region. We are reporting an unusual and rare variation in the branching pattern of external carotid artery in a 60-year-old female cadaver. A common trunk known as thyrolinguofacial trunk, originating from the anterior surface of the external carotid artery (right and left) giving of superior thyroid artery and a linguofacial trunk during a routine neck dissection. Read More

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http://dx.doi.org/10.5115/acb.2018.51.4.302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318451PMC
December 2018

Anatomical variations and developmental anomalies of the thyroid gland in Ethiopian population: a cadaveric study.

Anat Cell Biol 2018 Dec 29;51(4):243-250. Epub 2018 Dec 29.

Department of Anatomy, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Because of its embryonic origin, the thyroid gland is predisposed to multiple anatomical variations and developmental anomalies. These include the pyramidal lobe, the origin of levator glandular thyroidae, the absence of the isthmus, ectopic thyroid, accessory thyroid tissues, etc. These anatomical variations are clinically significant to surgeons, anatomists, and researchers. Read More

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http://dx.doi.org/10.5115/acb.2018.51.4.243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318459PMC
December 2018

Clinical Significance of Preoperative Embolization for Non-Hypervascular Metastatic Spine Tumors.

J Korean Neurosurg Soc 2019 Jan 31;62(1):106-113. Epub 2018 Dec 31.

Department of Orthopedic Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Objective: The efficacy of preoperative embolization for hypervascular metastatic spine disease (MSD) such as renal cell and thyroid cancers has been reported. However, the debate on the efficacy of preoperative embolization for non-hypervascular MSD still remains unsettled. The purpose of this study is to determine whether preoperative embolization for non-hypervascular MSD decreases perioperative blood loss. Read More

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http://dx.doi.org/10.3340/jkns.2018.0073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328796PMC
January 2019

Follicular cell lineage in persistent ultimobranchial remnants of mammals.

Authors:
Yoko Kameda

Cell Tissue Res 2019 Jan 8. Epub 2019 Jan 8.

Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa, 252-0374, Japan.

It has been a subject of much debate whether thyroid follicular cells originate from the ultimobranchial body, in addition to median thyroid primordium. Ultimobranchial remnants are detected in normal dogs, rats, mice, cattle, bison and humans and also in mutant mice such as Eya1 homozygotes, Hox3 paralogs homozygotes, Nkx2.1 heterozygotes and FRS2α. Read More

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http://link.springer.com/10.1007/s00441-018-02982-9
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http://dx.doi.org/10.1007/s00441-018-02982-9DOI Listing
January 2019
1 Read

Thrombectomy by direct cervical access in a case of common carotid occlusion with collateral supply to the Internal Carotid Artery: an uncommon anatomical variant.

World Neurosurg 2019 Jan 3. Epub 2019 Jan 3.

Department of Diagnostic and Interventional Neuroradiology, Foch Hospital, 40 rue Worth, 92150 Suresnes, France.

Background: Mechanical thrombectomy for acute ischaemic stroke recently proved its superiority to standard medical management alone. With the increasing number of procedures, practitioners are exposed to unexpected situations that may lead to failure of access and significantly worse clinical outcome. Being able to plan the procedure and to use alternative techniques may be useful in case of peculiar anatomy. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.12.133DOI Listing
January 2019

Predictive factors for non-small-volume central lymph node metastases (more than 5 or ≥ 2 mm) in clinically node-negative papillary thyroid carcinoma.

Medicine (Baltimore) 2019 Jan;98(1):e14028

Departments of Head and Neck Surgery.

The benefits of prophylactic central neck dissection (pCND) for treating patients with clinical node-negative (cN0) papillary thyroid carcinoma (PTC) remain controversial. Lymph node metastases have been strongly associated with local recurrence and low survival, especially in PTC patients with 5 or more or ≥2 mm metastatic lymph nodes. The following study investigates the incidence and risk factors of more than 5 or ≥2 mm metastatic lymph nodes in the central compartment. Read More

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http://dx.doi.org/10.1097/MD.0000000000014028DOI Listing
January 2019

Differences in treatment outcomes between ultrasound-guided percutaneous microwave ablation and endoscopic thyroidectomy for patients with papillary thyroid microcarcinoma: Protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2019 Jan;98(1):e13953

Department of Medical Ultrasound.

Background: The differences in treatment outcomes between ultrasound (US)-guided percutaneous microwave ablation (PMWA) and endoscopic thyroidectomy for patients with papillary thyroid microcarcinoma (PTMC) remains unknown.

Methods: An electronic search will be performed for randomized controlled trials or observational studies that reported recurrence and mortality rates in PTMC patients with US-guided PMWA or endoscopic thyroidectomy. Hazard ratios with their 95% confidence intervals will be calculated using fixed- or random-effects models according to heterogeneity. Read More

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http://dx.doi.org/10.1097/MD.0000000000013953DOI Listing
January 2019

Routine Intraoperative Neuromonitoring of the Recurrent Laryngeal Nerve to Facilitate Complete Resection and Ensure Safety in Thyroid Cancer Surgery.

Am Surg 2018 Dec;84(12):1882-1888

Routine use of intraoperative neuromonitoring (IONM) in thyroid cancer surgery is controversial. We aimed to investigate whether it improves the completeness of thyroidectomy and ensures safety. This retrospective study included 380 thyroid cancer patients who underwent thyroidectomy, by one surgeon, between July 2006 and November 2015. Read More

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December 2018

Performance of Serum Glypican 3 in Diagnosis of Hepatocellular Carcinoma: A meta-analysis.

Ann Hepatol 2018 Dec;18(1):58-67

Department of Human Anatomy, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, China.

Introduction And Aim: Serum glypican-3 (GPC3) has been explored as a non-invasive biomarker of hepatocellular carcinoma (HCC). However, controversy remains on its diagnostic accuracy. Therefore, we aimed to conduct a systematic review and metaanalysis to evaluate the differential diagnostic accuracy of serum GPC3 between HCC and liver cirrhosis (LC) cases. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7863DOI Listing
December 2018

Ultrasound risk evaluation of thyroid nodules that are "unspecified" in the 2015 American Thyroid Association management guidelines: A retrospective study.

Medicine (Baltimore) 2018 Dec;97(52):e13914

Department of Ultrasound, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing, China.

This study sought to assess the malignant risks of "unspecified" thyroid nodules; that is, nodules that were not of a type described in the 2015 American Thyroid Association (ATA) guidelines.We retrospectively reviewed medical records and ultrasound (US) data for 1808 consecutive patients with 2614 thyroid nodules who underwent thyroidectomy between January 2015 and December 2015. Nodules with US features that did not satisfy the criteria for any risk category in the 2015 ATA guidelines were defined as "unspecified" nodules. Read More

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http://dx.doi.org/10.1097/MD.0000000000013914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314728PMC
December 2018
2 Reads

BRAF-positive Multifocal and Unifocal Papillary Thyroid Cancer Show Different mRNA Expressions.

Clin Endocrinol (Oxf) 2018 Dec 28. Epub 2018 Dec 28.

Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea.

Objective: Thyroid cancer is the most common malignant endocrine tumor, and its incidence has continuously increased worldwide over the past three decades. We focused on the association of multifocal PTC with mRNA expression to characterize how molecular and histopathologic features relate to multifocality.

Design: A retrospective cohort study. Read More

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http://doi.wiley.com/10.1111/cen.13928
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http://dx.doi.org/10.1111/cen.13928DOI Listing
December 2018
4 Reads

MicroRNA Expression in the Progression and Aggressiveness of Papillary Thyroid Carcinoma.

Anticancer Res 2019 Jan;39(1):33-40

Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wroclaw, Poland.

In the last two decades microRNAs have received great attention in research because of their ability to regulate gene expression. Many studies have shown that defects in different microRNA molecules are linked to many diseases; however, their contribution towards thyroid disease has not been fully explored. Herein, we present a short review of the present state of knowledge on microRNAs, such as their origin, their biogenesis and biological function, as well as their differential expression in papillary thyroid carcinoma. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13077DOI Listing
January 2019
4 Reads

Differential effects of hypo- and hyperthyroidism on remodeling of contacts between neurons expressing the neuropeptide EI and tyrosine hydroxylase in hypothalamic areas of the male rat.

Peptides 2018 Dec 24;113:1-10. Epub 2018 Dec 24.

Laboratorio de Neurobiología, Instituto de Embriología e Histología (IHEM-CONICET), Facultad de Ciencias Médicas, Universidad Nacional de Cuyo (UNCuyo), 5500, Mendoza, Argentina.

The Neuropeptide EI (NEI, glutamic acid- isoleucine amide) participates in neuroendocrine function. Previously we demonstrated that NEI concentration is regulated by thyroid hormones in discrete hypothalamic areas in rats. We observed that the thyroid status affects the dopaminergic regulation of the pituitary hormones. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.12.008DOI Listing
December 2018

Toward automated and personalized organ dose determination in CT examinations - A comparison of two tissue characterization models for Monte Carlo organ dose calculation with a Therapy Planning System.

Med Phys 2018 Dec 24. Epub 2018 Dec 24.

Medical Radiation Sciences, Department of Immunology, Genetics and Pathology, Uppsala University, Sjukhusfysik Ing. 82, Akademiska Sjukhuset, SE-751 85, Uppsala, Sweden.

Purpose: Computed tomography (CT) is a versatile tool in diagnostic radiology with rapidly increasing number of examinations per year globally. Routine adaption of the exposure level for patient anatomy and examination protocol cause the patients' exposures to become diversified and harder to predict by simple methods. To facilitate individualized organ dose estimates, we explore the possibility to automate organ dose calculations using a radiotherapy treatment planning system (TPS). Read More

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http://dx.doi.org/10.1002/mp.13357DOI Listing
December 2018

The downregulation of lncRNA EMX2OS might independently predict shorter recurrence-free survival of classical papillary thyroid cancer.

PLoS One 2018 21;13(12):e0209338. Epub 2018 Dec 21.

Department of Anatomy, Histology and Embryology, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Homeobox protein Emx2 is a transcription factor that is encoded by the EMX2 gene. In this study, using data from the Cancer Genome Atlas-Thyroid Cancer (TCGA-THCA), we aimed to examine the expression profile of EMX2 and its antisense transcript EMX2OS in papillary thyroid cancer (PTC), their prognostic value and potential regulatory networks. Results showed that in the three variants of PTC, EMX2 was significantly downregulated in classical PTC, while EMX2OS were significantly downregulated in follicular and classical PTC, compared with adjacent normal tissues. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209338PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303026PMC
December 2018

Extensive peritoneal implant metastases of malignant struma ovarii treated by thyroidectomy and 131I therapy: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13867

Department of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Rationale: Malignant struma ovarii is extremely rare in the clinic. The diagnosis and modalities of treatment are still controversial. Here we describe a case of extensive peritoneal implant metastasis originating from malignant struma ovarii discovered 14 years after ovariectomy and chemotherapy. Read More

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http://dx.doi.org/10.1097/MD.0000000000013867DOI Listing
December 2018
1 Read

An anatomical hypothesis: a "concentric-structured model" for the theoretical understanding of the surgical anatomy in the upper mediastinum required for esophagectomy with radical mediastinal lymph node dissection.

Dis Esophagus 2018 Dec 17. Epub 2018 Dec 17.

Department of Esophageal Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

Understanding the surgical anatomy is the key to reducing surgical invasiveness especially in the upper mediastinal dissection for esophageal cancer, which is supposed to have a significant impact on curability and morbidity. However, there is no theoretical recognition regarding the surgical anatomy required for esophagectomy, although the surgical anatomy in abdominal digestive surgery has been developed on the basis of embryological findings of intestinal rotation and fusion fascia. Therefore, we developed a hypothesis of a 'concentric-structured model' of the surgical anatomy in the upper mediastinum based on human embryonic development. Read More

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http://dx.doi.org/10.1093/dote/doy119DOI Listing
December 2018

Upregulation of the solute carrier family 7 genes is indicative of poor prognosis in papillary thyroid carcinoma.

World J Surg Oncol 2018 Dec 17;16(1):235. Epub 2018 Dec 17.

Department of Thyroid Breast Oncology, Shanghai East Hospital, School of Medicine, Tongji University School of Medicine, No.150 Jimo Road, Shanghai, 200120, China.

Background: The solute carrier (SLC) 7 family genes comprise 14 members and function as cationic amino acid/glycoprotein transporters in many cells, they are essential for the maintenance of amino acid nutrition and survival of tumor cells. This study was conducted to analyze the associations of SLC7 family gene expression with mortality in papillary thyroid carcinoma (PTC).

Methods: Clinical features, somatic mutations, and SLC7 family gene expression data were downloaded from The Cancer Genome Atlas database. Read More

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https://wjso.biomedcentral.com/articles/10.1186/s12957-018-1
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http://dx.doi.org/10.1186/s12957-018-1535-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297957PMC
December 2018
8 Reads

Characterization and prognosis of estrogen receptor-positive/progesterone receptor-negative male breast cancer: a population-based study.

World J Surg Oncol 2018 Dec 17;16(1):236. Epub 2018 Dec 17.

Department of Thyroid and Breast Surgery, Clinical Medical College of Yangzhou University and Northern Jiangsu People's Hospital, Yangzhou, China.

Background: The aim of this study was to explore the characteristics and prognostic information of estrogen receptor-positive/progesterone receptor-negative (ER+/PR-) male breast cancer.

Methods: Using the US National Cancer Institute's Surveillance, Epidemiology, and End Results database, we compared the demographics, clinical characteristics, and outcome of estrogen receptor-positive/progesterone receptor-positive (ER+/PR+) patients with ER+/PR- male breast cancer patients from 1990 to 2010. Two thousand three hundred twenty-two patients with ER+/PR+ tumors and 355 patients with ER+/PR- tumors were included in our study. Read More

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http://dx.doi.org/10.1186/s12957-018-1539-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297954PMC
December 2018

Axillary lymph node metastasis as the first manifestation of male occult breast cancer: A Case Report.

Medicine (Baltimore) 2018 Dec;97(50):e13706

Department of Radiotherapy, The Second Hospital of Jilin University, Changchun, Jilin Province, China.

Rational: Occult breast cancer (OBC) is an extremely rare breast cancer and is defined by the presence of axillary metastasis without a primary tumor in the breasts or any abnormality on radiologic examination.

Patient Concerns: This case report presents a 49-year-old man who was diagnosed with male OBC, which first manifested as an axillary lymph node metastasis followed by the emergence of infraclavicular lymph node metastasis. Neither the breast nor other organs had any abnormality. Read More

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http://dx.doi.org/10.1097/MD.0000000000013706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320098PMC
December 2018
5.723 Impact Factor

Controversy regarding when clinically suspicious thyroid nodules should be subjected to surgery: Review of current guidelines.

Medicine (Baltimore) 2018 Dec;97(50):e13634

Background: The work-up of a thyroid nodule to diagnose malignancy is not always straightforward. There are various international thyroid societies each with their own guidelines on the approach to a thyroid nodule. The aim is therefore to determine whether a clinically suspicious thyroid nodule should be subjected to surgery. Read More

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http://dx.doi.org/10.1097/MD.0000000000013634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320209PMC
December 2018

Bony Orbital Volume Expansion in Thyroid Eye Disease.

Ophthalmic Plast Reconstr Surg 2018 Dec 7. Epub 2018 Dec 7.

Doheny Eye Institute, Division of Orbital and Ophthalmic Plastic Surgery, University of California-Los Angeles, Los Angeles, California, U.S.A.

Purpose: To quantify changes to the bony orbital volume (BOV) in patients with thyroid eye disease (TED) relative to normal controls.

Methods: In this case-control study, all patients affected with TED seen over a 2-year period were screened for study entry. Eligible participants were adults with clinical evidence of TED and CT scans of their orbits obtained during the course of their routine care. Read More

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http://Insights.ovid.com/crossref?an=00002341-900000000-9837
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http://dx.doi.org/10.1097/IOP.0000000000001292DOI Listing
December 2018
13 Reads

Thyroid incidentaloma as a "PAIN" phenomenon- does it always require surgery?

Medicine (Baltimore) 2018 Dec;97(49):e13339

First Department and Clinic of General, Gastroenterological and Endocrine Surgery.

A thyroid nodule discovered during imaging study performed due to unrelated thyroid disease is known as a thyroid incidentaloma, while positron emission tomography (PET) associated incidental neoplasm of thyroid is known as a "PAIN" phenomenon.To evaluate which patients with "PAIN" phenomenon should undergo surgery in regards to cytology results.Retrospective review of 4716 patients consecutively admitted and surgically treated in tertiary surgical center. Read More

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http://dx.doi.org/10.1097/MD.0000000000013339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310517PMC
December 2018
1 Read

General hyperpigmentation induced by Grave's disease: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13279

Department of Endocrinology, The Second Affiliated Hospital of Zhejiang University School of Medicine.

Rationale: Hyperpigmentation is a common skin disease. However, there are few reported cases of Grave's disease with diffuse hyperpigmentation. We hereby described a rare case with diffuse hyperpigmentation induced by Grave's disease. Read More

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http://dx.doi.org/10.1097/MD.0000000000013279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310574PMC
December 2018
5 Reads

Upregulation of thyroid hormone receptor interactor 13 is associated with human hepatocellular carcinoma.

Oncol Rep 2018 Dec 4;40(6):3794-3802. Epub 2018 Oct 4.

Nantong Institute of Liver Disease, Nantong Third People's Hospital, Nantong University, Nantong, Jiangsu 226006, P.R. China.

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality worldwide. Thyroid hormone receptor interactor 13 (TRIP13) has been reported to promote nonhomologous end joining (NHEJ). However, the role of TRIP13 in the molecular pathogenesis of HCC remains to be elucidated. Read More

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http://dx.doi.org/10.3892/or.2018.6767DOI Listing
December 2018

Combination of serum microRNAs and ultrasound profile as predictive biomarkers of diagnosis and prognosis for papillary thyroid microcarcinoma.

Oncol Rep 2018 Dec 9;40(6):3611-3624. Epub 2018 Oct 9.

Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.

Circulating microRNAs (miRNAs) are promising diagnostic markers in various types of cancers, including papillary thyroid carcinoma (PTC). However, there is sparse information reported with regards to miRNA expression in papillary thyroid microcarcinoma (PTMC) or concerning the role of a combination of miRNAs and ultrasound (US) in the diagnosis of PTMC before surgery. Therefore, we designed a study that aimed to evaluate miRNA expression levels and their potential associations with US findings and determine whether miRNAs could be used as diagnostic and prognostic biomarkers of PTMC. Read More

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http://dx.doi.org/10.3892/or.2018.6776DOI Listing
December 2018

The Impact of Goiter and Thyroid Surgery on Goiter Related Esophageal Dysfunction. A Systematic Review.

Front Endocrinol (Lausanne) 2018 20;9:679. Epub 2018 Nov 20.

Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark.

Patients with goiter referred for thyroidectomy report swallowing difficulties. This might be associated with esophageal compression and deviation as this is present in a significant number of patients. Studies on how goiter and subsequently its treatment affect the esophagus are sparse and point in various directions. Read More

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http://dx.doi.org/10.3389/fendo.2018.00679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256339PMC
November 2018
1 Read

Vascular Endothelial Growth Factor (VEGF) Induced Downstream Responses to Transient Receptor Potential Vanilloid 1 (TRPV1) and 3-Iodothyronamine (3-TAM) in Human Corneal Keratocytes.

Front Endocrinol (Lausanne) 2018 22;9:670. Epub 2018 Nov 22.

Klinik für Augenheilkunde, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

This study was undertaken to determine if crosstalk among the transient receptor potential (TRP) melastatin 8 (TRPM8), TRP vanilloid 1 (TRPV1), and vascular endothelial growth factor (VEGF) receptor triad modulates VEGF-induced Ca signaling in human corneal keratocytes. Using RT-PCR, qPCR and immunohistochemistry, we determined TRPV1 and TRPM8 gene and protein coexpression in a human corneal keratocyte cell line (HCK) and human corneal cross sections. Fluorescence Ca imaging using both a photomultiplier and a single cell digital imaging system as well as planar patch-clamping measured relative intracellular Ca levels and underlying whole-cell currents. Read More

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http://dx.doi.org/10.3389/fendo.2018.00670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262029PMC
November 2018

Mechanisms of disease: The endocrinology of obstructive sleep apnoea.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

A Tahrani, University of Birmingham, Institute of Metabolism and Systems Research, Birmingham, United Kingdom of Great Britain and Northern Ireland.

Obstructive sleep apnoea (OSA) is a common disorder that is associated with serious co-morbidities with a negative impact on quality of life, life expectancy and health costs. As OSA is related to obesity and is associated with sleep disruption, increased inflammation and oxidative stress, it is not surprising that OSA has an impact on the secretion of multiple hormones and is implicated in the development of many endocrine conditions. On the other hand, many endocrine conditions that can affect obesity and/or upper airways anatomy and stability have been implicated in the development or worsening of OSA. Read More

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http://dx.doi.org/10.1530/EJE-18-0411DOI Listing
December 2018
1 Read

Morphological features predictive for BRAF(V600E) mutation in papillary thyroid microcarcinomas.

Rom J Morphol Embryol 2018 ;59(3):747-753

Department of Histology, University of Medicine and Pharmacy of Tîrgu Mureş, Romania;

Background: The B-Raf proto-oncogene serine∕threonine kinase (BRAF) V600E (BRAF(V600E)) mutation represents a very specific marker for papillary thyroid carcinoma (PTC), including microcarcinomas (PTMCs). However, assessment of the BRAF(V600E) mutational status is expensive and not available in all pathology laboratories.

Aim: We aimed to evaluate if we can identify those morphological features that could predict the presence of the BRAF(V600E) mutation in a series of PTMCs. Read More

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December 2018

Prognostic significance of cell-adhesion molecules in histological variants of papillary thyroid carcinoma.

Rom J Morphol Embryol 2018 ;59(3):721-727

Department of Morphofunctional Sciences I, "Grigore T. Popa" University of Medicine and Pharmacy, Iaşi, Romania;

The molecular structure of E-cadherin and its function are intimately related to β-catenin, their interactions ensuring the cell morphology and stability. Alterations of E-cadherin-β-catenin complex facilitate the tumor growth and spreading in the carcinogenic mechanism. We aimed to assess the E-cadherin and β-catenin immunoexpressions in different variants of papillary thyroid carcinoma (PTC), and the relationship of these markers with the clinicopathological prognostic factors. Read More

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December 2018

Patient Satisfaction after Aesthetic Chondrolaryngoplasty.

Plast Reconstr Surg Glob Open 2018 Oct 3;6(10):e1877. Epub 2018 Oct 3.

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology - Head and Neck Surgery, Boston University School of Medicine, Boston, Mass.

Background: Patient's pursuing aesthetic surgery often inquire about the success of the procedure. Having objective data for these patients improves preoperative counseling. To assess patient satisfaction after aesthetic chondrolaryngoplasty using specifically developed outcomes assessment instrument and to evaluate the anatomy of the vocalis insertion on the thyroid cartilage and its effect on the extent of surgical resection. Read More

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http://dx.doi.org/10.1097/GOX.0000000000001877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250475PMC
October 2018
8 Reads

Symmetrical Apophyses on the Posterior Margins of the Thyroid Cartilage: A Previously Undescribed Anatomical Variation With Potential Forensic Implications.

Am J Forensic Med Pathol 2018 Dec 6. Epub 2018 Dec 6.

Departamento de Anatomía y Embriología Humana Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.

Differential diagnosis between normal/variant anatomy and pathological/traumatic findings represents one of the main matters of investigation of the so-called forensic clinical anatomy. In the literature, many anatomical variations of the laryngeal thyroid cartilage have been reported, with potential implications in forensic pathology. They include triticeal cartilages, foramen thyroideum, asymmetry, segmentation or agenesis of the superior thyroid horns, bone connections with the hyoid bone, absence of cricothyroid facets, hypertrophy of the inferior thyroid tubercle, and asymmetries in the thyroid notch, isthmus, or length of the inferior horn. Read More

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http://Insights.ovid.com/crossref?an=00000433-900000000-9917
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http://dx.doi.org/10.1097/PAF.0000000000000452DOI Listing
December 2018
1 Read

Peritumoral implantation of hydrogel-containing nanoparticles and losartan for enhanced nanoparticle penetration and antitumor effect.

Int J Nanomedicine 2018 13;13:7409-7426. Epub 2018 Nov 13.

Department of Thyroid and Breast Surgery, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China,

Background And Purpose: Nanoparticle-loaded hydrogels - localized drug delivery devices containing a combination of therapeutic nanoparticles and implantable hydrogel - have been recipients of increased focus and interest for cancer treatment. However, it is difficult for the released nanoparticles to penetrate deeply into tumors because of the dense collagen network in the tumor extracellular matrix, which greatly limits their antitumor effect. We hypothesized that the implantation of a hydrogel loaded with both nanoparticles and losartan (Los) might enhance penetration because Los has been proven to effectively reduce collagen levels in various tumors. Read More

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http://dx.doi.org/10.2147/IJN.S178585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239105PMC
January 2019
1 Read

Validation of ultrasound as a diagnostic tool to assess vocal cord motion in an animal feasibility study.

Gland Surg 2018 Oct;7(5):433-439

Department of Otolaryngology, Head and Neck Surgery, University of Tennessee Health Science Center, Memphis, TN, USA.

Background: Post-thyroidectomy dysphonia can result from recurrent laryngeal nerve (RLN) injury. Confirmation of postoperative recurrent nerve function has prompted many surgeons to advocate laryngoscopic examination. Indirect and flexible laryngoscopy permit visualization of vocal cord motion, but not all thyroid surgeons are skilled in these techniques. Read More

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http://gs.amegroups.com/article/view/20738/21353
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http://dx.doi.org/10.21037/gs.2018.07.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234245PMC
October 2018
4 Reads

Expression of Metallothionein I/II and Ki-67 Antigen in Graves' Disease.

Anticancer Res 2018 Dec;38(12):6847-6853

Department of Histology and Embryology, Medical University of Wroclaw, Wroclaw, Poland.

Background/aim: The expression of metallothionein I/II (MT-I/II) was examined in thyroids of Graves' disease (GD) and nodular goiter (NG) patients to determine its role as a potential marker of proliferation and autoimmune inflammation in the thyroid.

Patients And Methods: MT-I/II and Ki-67 antigen expression was studied using immunohistochemistry in 72 GD and 24 NG patients.

Results: MT-I/II expression was noted in the cytoplasm and nuclei of thyrocytes of GD and NG patients. Read More

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http://dx.doi.org/10.21873/anticanres.13059DOI Listing
December 2018
3 Reads

Effect of Heparin-Protamine Treatment on Thyroid Cancer Cell Lines.

Anticancer Res 2018 Dec;38(12):6759-6762

Division of Molecular Cell Biology, Core Research Facilities of Basic Science, The Jikei University School of Medicine, Tokyo, Japan.

Background: Anticoagulation therapy is often used to prevent stroke in patients with thyroid cancer. However, the effects of heparin and protamine on thyroid cancer are unknown; therefore, we examined the response of thyroid cancer cell lines to heparin and protamine.

Materials And Methods: Cytotoxic assay for heparin-protamine treatment was examined on SW1736, 8505c and 8305c cell lines. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13046DOI Listing
December 2018
5 Reads

Percutaneous laser ablation of benign thyroid nodules: a one year follow-up study.

Einstein (Sao Paulo) 2018 Nov 29;16(4):eAO4279. Epub 2018 Nov 29.

Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.

Objective: To evaluate safety and effectiveness of nodule volume reduction and thyroid function after percutaneous laser ablation treatment in patients with benign nonfunctioning thyroid nodules.

Methods: Prospective single-center study, from January 2011 to October 2012, which evaluated 30 euthyroid and thyroid antibodies negative patients with benign solitary or dominant nodule with indication of treatment due to compressive symptoms and aesthetic disturbances. The clinical and laboratory (thyroid ultrasound, TSH, FT4, TG, TG-Ab, TPO-Ab and TRAb levels) evaluations were performed before the procedure, and periodically 1 week, 3 months and 6 months after. Read More

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https://journal.einstein.br/pt-br/article/ablacao-percutanea
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http://dx.doi.org/10.31744/einstein_journal/2018AO4279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276810PMC
November 2018
5 Reads

Level VI lymph nodes: an anatomic study of lymph nodes located between the recurrent laryngeal nerve and the right common carotid artery.

Rev Col Bras Cir 2018 Nov 29;45(6):e1972. Epub 2018 Nov 29.

Universidade de São Paulo, Faculdade de Medicina, Disciplina de Topografia Estrutural Humana, São Paulo, SP, Brasil.

Objective: to describe the presence of lymph nodes and their relationships with demographic and anthropometric characteristics in a specific region, not yet described in anatomy compendiums, called by us Recurrent Carotid Recess (RCR) and located among the right recurrent laryngeal nerve, the right common carotid artery, and the right inferior thyroid artery.

Methods: 32 right cervical regions were harvested from cadavers within 24 hours post-mortem. The fibro-fatty tissue of the RCR was resected and prepared with formalin fixation. Read More

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http://dx.doi.org/10.1590/0100-6991e-20181972DOI Listing
November 2018
1 Read

[A toddler with a rare complication of scarlet fever].

Ned Tijdschr Geneeskd 2018 11 26;162. Epub 2018 Nov 26.

Reinier de Graaf Gasthuis, afd. Kindergeneeskunde, Delft.

Background: Haemolytic group A streptococci (GAS) are the most common bacterial cause of infection in the Netherlands. These bacteria can cause many different non-invasive infections, including scarlet fever.

Case Description: A two-year-old girl presented with fever, tachycardia, exanthema and swelling in the neck. Read More

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November 2018
2 Reads

MMP-9-1562 C/T single nucleotide polymorphism associates with increased MMP-9 level and activity during papillary thyroid carcinoma progression.

Pathology 2019 Jan 27;51(1):55-61. Epub 2018 Nov 27.

Institute for the Application of Nuclear Energy-INEP, University of Belgrade, Belgrade, Serbia. Electronic address:

Papillary thyroid carcinoma (PTC), a common form of thyroid malignancy, displays significant variations in clinical features and outcome. The malignant transformation of the thyroid is driven by altered expression of many matrix-modulating enzymes, including matrix metalloproteinase-9 (MMP-9). A single nucleotide polymorphism in its promotor (-1562 C/T) is suspected to cause overexpression of MMP-9, which in turn contributes to development of a tumour unfavourable phenotype. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.10.008DOI Listing
January 2019

A Contemporary and Novel Use of Thyroid Cartilage for Structural Grafting in Esthetic Rhinoplasty: A Case Report.

J Oral Maxillofac Surg 2018 Nov 2. Epub 2018 Nov 2.

American Academy of Cosmetic Surgery Fellowship Director, Cosmetic Surgery Affiliates, Oklahoma City, OK.

This case report details a 21-year-old transgender female patient who underwent a concomitant trichophytic brow lift with frontal bone reduction, tracheal shave (also known as thyroid chondroplasty), and rhinoplasty for facial feminization in conjunction with her transitioning process. During rhinoplasty, harvesting cartilage for structural grafting is often necessary, and this is typically done from a distant, unrelated surgical site. During this case, cartilage from the thyroid lamina was utilized in the form of a columellar strut graft. Read More

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http://dx.doi.org/10.1016/j.joms.2018.10.019DOI Listing
November 2018

Prognostic value of sorting nexin 10 weak expression in stomach adenocarcinoma revealed by weighted gene co-expression network analysis.

World J Gastroenterol 2018 Nov;24(43):4906-4919

Department of Gastric Cancer, Liaoning Cancer Hospital and Institute (Cancer Hospital of China Medical University), Shenyang 110042, Liaoning Province, China.

Aim: To detect significant clusters of co-expressed genes associated with tumorigenesis that might help to predict stomach adenocarcinoma (SA) prognosis.

Methods: The Cancer Genome Atlas database was used to obtain RNA sequences as well as complete clinical data of SA and adjacent normal tissues from patients. Weighted gene co-expression network analysis (WGCNA) was used to investigate the meaningful module along with hub genes. Read More

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http://dx.doi.org/10.3748/wjg.v24.i43.4906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250920PMC
November 2018
2.369 Impact Factor

VDR gene FokI polymorphism as a poor prognostic factor for papillary thyroid cancer.

Tumour Biol 2018 Nov;40(11):1010428318811766

1 Department of Endocrinology and Metabolism, Ankara Diskapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey.

This is the first study to investigate the effect of vitamin D receptor ( VDR) gene single-nucleotide polymorphisms on the clinicopathologic features of papillary thyroid cancer in Turkey. A total of 165 patients with papillary thyroid cancer and 172 controls were included in this case-control study. VDR gene single-nucleotide polymorphisms FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236) were evaluated using reverse-transcription polymerase chain reaction. Read More

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http://dx.doi.org/10.1177/1010428318811766DOI Listing
November 2018

Parathyroid imaging by (18)F-fluorocholine PET/CT in patients with primary hyperparathyroidism and inconclusive conventional methods: clinico-pathological correlations.

Physiol Res 2018 Nov;67(Supplementum 3):S551-S557

Institute of Endocrinology, Prague, Czech Republic.

(18)F-fluorocholine positron emission tomography/computed tomography (FCH) was performed after inconclusive neck ultrasound and (99)Tc-sestaMIBI SPECT (MIBI) scintigraphy in patients with primary hyperparathyroidism (PHPT) to localize abnormal parathyroid glands before surgery. The results were retrospectively evaluated and compared to postoperative histopathological findings. 13 patients with PHPT were enrolled (mean age 64. Read More

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November 2018
1 Read

Genetic predictors of the development and recurrence of Graves' disease.

Physiol Res 2018 Nov;67(Supplementum 3):S431-S439

Department of Molecular Endocrinology, Institute of Endocrinology, Prague, Czech Republic.

Graves' disease affects approximately 3 % of women and 0.5 % of men. The first-choice therapy is based on the administration of thyrostatic drugs. Read More

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November 2018

Intraoperative carbon nanoparticles mapping in secondary total thyroidectomy for recurrent thyroid nodules: Results of a 8-criterion case-match study (case control study).

Int J Surg 2018 Dec 23;60:210-215. Epub 2018 Nov 23.

Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. Electronic address:

Background: The extent of total thyroidectomy in the management of multinodular goiter remains unclear. Compared to primary thyroidectomy, secondary total thyroidectomy is more difficult to perform and carries a significantly higher risk of postoperative complications such as recurrent laryngeal nerve (RLN) palsy or hypoparathyroidism. In this study, we aimed to evaluate the efficacy and safety of intraoperative carbon nanoparticle (CN) mapping in patients undergoing secondary total thyroidectomy. Read More

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http://dx.doi.org/10.1016/j.ijsu.2018.11.014DOI Listing
December 2018
3 Reads