61,780 results match your criteria Thyroid Anatomy


Potential forensic implications of therapy - a traditional Indonesian therapy associated with neck bruising.

Med Sci Law 2020 Jun 5:25802420926867. Epub 2020 Jun 5.

Faculty of Medicine, The University of Adelaide, Australia.

is a traditional Indonesian treatment involving abrading the skin over various parts of the body with a blunt object such as a coin or a piece of ginger which may create suspicious injuries. Here, the case of a 30-year-old woman who had undergone therapy is reported. She was complaining of retro-sternal pain and epigastric discomfort and subsequently became markedly short of breath and died. Read More

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http://dx.doi.org/10.1177/0025802420926867DOI Listing

A three-dimensional computed tomography angiography study of the anatomy of the accessory middle colic artery and implications for colorectal cancer surgery.

Surg Radiol Anat 2020 Jun 4. Epub 2020 Jun 4.

Department of Gastroenterological, General, Breast and Thyroid Surgery, Faculty of Medicine, Yamagata University, Yamagata, 990-9585, Japan.

Purpose: In the present study, we focused on the accessory middle colic artery and aimed to increase the safety and curative value of colorectal cancer surgery by investigating the artery course and branching patterns.

Methods: We included 143 cases (mean age, 70.4 ± 11. Read More

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http://dx.doi.org/10.1007/s00276-020-02511-wDOI Listing

Origin variations of the superior thyroid, lingual, and facial arteries: a computed tomography angiography study.

Surg Radiol Anat 2020 Jun 1. Epub 2020 Jun 1.

Departamento de Anatomía Humana, Facultad de Medicina, Universidad Autónoma de Nuevo León, Francisco I. Madero and Aguirre Pequeño Sin Numero, Colonia Mitras Centro Monterrey, 64460, Nuevo León, Mexico.

Purpose: To determine the anatomical variations and morphology of the external carotid artery (ECA) and its anterior branches.

Methods: Using computed tomography angiography (CTA), the origin, internal diameter, and surface laterality emergence of the superior thyroid (STA), lingual (LA), and facial (FA) arteries were evaluated retrospectively evaluated and classified. The bifurcation level of the common carotid artery (CCA) in relation to the cervical vertebrae and disc was also determined. Read More

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http://dx.doi.org/10.1007/s00276-020-02507-6DOI Listing

Core functional nodes and sex-specific pathways in human ischaemic and dilated cardiomyopathy.

Nat Commun 2020 Jun 2;11(1):2843. Epub 2020 Jun 2.

Precision Cardiovascular Laboratory, The University of Sydney, Sydney, NSW, Australia.

Poor access to human left ventricular myocardium is a significant limitation in the study of heart failure (HF). Here, we utilise a carefully procured large human heart biobank of cryopreserved left ventricular myocardium to obtain direct molecular insights into ischaemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM), the most common causes of HF worldwide. We perform unbiased, deep proteomic and metabolomic analyses of 51 left ventricular (LV) samples from 44 cryopreserved human ICM and DCM hearts, compared to age-, gender-, and BMI-matched, histopathologically normal, donor controls. Read More

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http://dx.doi.org/10.1038/s41467-020-16584-zDOI Listing

Ultrasonographic and anatomical examination of normal thyroid and internal parathyroid glands in goats.

PLoS One 2020 29;15(5):e0233685. Epub 2020 May 29.

Department of Morphological Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, Warsaw, Poland.

Ultrasonographic examination of the normal thyroid and parathyroid glands has been described for humans and many animal species. However, similar reports for goats are still missing. The aim of the study was to present ultrasound features of the normal thyroid and internal parathyroid glands in goats with the determination of their dimensions and volume, followed by a comparison of the results to the gross examination. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233685PLOS

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.

Cell 2020 05 27;181(5):1016-1035.e19. Epub 2020 Apr 27.

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Program in Immunology, Harvard Medical School, Boston, MA 02115, USA; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-CoV-2 spike (S) protein binds angiotensin-converting enzyme 2 (ACE2), and in concert with host proteases, principally transmembrane serine protease 2 (TMPRSS2), promotes cellular entry. The cell subsets targeted by SARS-CoV-2 in host tissues and the factors that regulate ACE2 expression remain unknown. Read More

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http://dx.doi.org/10.1016/j.cell.2020.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252096PMC

A simple, efficient, and safe way of finding recurrent laryngeal nerve beneficial for PTC patients.

Medicine (Baltimore) 2020 May;99(19):e20138

Department of Thyroid and Vascular Surgery.

Background: More surgeons have known the importance of parathyroid grand and recurrent laryngeal nerve protection in the surgery, but there is still plenty of scope to improve the surgical techniques. This study aims at investigating whether the improved method of finding recurrent laryngeal nerve (RLN) can protect parathyroid grand and RLN.

Methods: One hundred fifty-eight patients were enrolled and divided randomly into the test and control group according to different methods of finding RLN in the surgery. Read More

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http://dx.doi.org/10.1097/MD.0000000000020138DOI Listing

A phase I/IIa double blind single institute trial of low dose sirolimus for Pendred syndrome/DFNB4.

Medicine (Baltimore) 2020 May;99(19):e19763

Department of Otorhinolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.

Introduction: Pendred syndrome (PDS)/DFNB 4 is a disorder with fluctuating and progressive hearing loss, vertigo, and thyroid goiter. We identified pathophysiology of a neurodegenerative disorder in PDS patient derived cochlear cells that were induced via induced pluripotent stem cells and found sirolimus, an mTOR inhibitor, as an inhibitor of cell death with the minimum effective concentration less than 1/10 of the approved dose for other diseases. Given that there is no rational standard therapy for PDS, we planned a study to examine effects of low dose oral administration of sirolimus for the fluctuating and progressive hearing loss, and the balance disorder of PDS by daily monitor of their audio-vestibular symptoms. Read More

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http://dx.doi.org/10.1097/MD.0000000000019763DOI Listing

Main Surgical Principles and Methods in Surgical Treatment of Primary Hyperparathyroidism.

Sisli Etfal Hastan Tip Bul 2019 3;53(4):337-352. Epub 2019 Dec 3.

Department of Genaral Surgery, Bahcesehir University, Faculty of Medicine, Istanbul, Turkey.

The only curative treatment for primary hyperparathyroidism (pHPT) is surgery. The most important factors that increase the success rate of a parathyroidectomy are the establishment of the correct diagnosis and the surgeon's good knowledge of anatomy and embryology. The lower parathyroid glands develop from the dorsal portion of the third pharyngeal pouch, and the upper parathyroid glands from the fourth pharyngeal pouch. Read More

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http://dx.doi.org/10.14744/SEMB.2019.67944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192302PMC
December 2019

A Triple-negative Matrix-producing Breast Carcinoma Patient-derived Orthotopic Xenograft (PDOX) Mouse Model Is Sensitive to Bevacizumab and Vinorelbine, Regressed by Eribulin and Resistant to Olaparib.

Anticancer Res 2020 May;40(5):2509-2514

AntiCancer Inc, San Diego, CA, U.S.A.

Background/aim: Matrix-producing breast carcinoma (MPBC) is a rare and usually aggressive triple-negative breast cancer (TNBC). In this study, we determined drug sensitivity for a triple-negative MPBC, without BRCA mutations, in a patient-derived orthotopic xenograft (PDOX) model.

Materials And Methods: The MPBC PDOX model was established in the left 2 mammary gland of nude mouse by implantation of the patient tumor using surgical orthotopic implantation (SOI). Read More

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http://dx.doi.org/10.21873/anticanres.14221DOI Listing

Eribulin Regresses a Cisplatinum-resistant Rare-type Triple-negative Matrix-producing Breast Carcinoma Patient-derived Orthotopic Xenograft Mouse Model.

Anticancer Res 2020 May;40(5):2475-2479

AntiCancer Inc, San Diego, CA, U.S.A.

Background/aim: Matrix-producing breast carcinoma (MPBC) is a rare and usually aggressive triple-negative breast cancer (TNBC). In the present report, we determined the drug sensitivity for a triple-negative MPBC using a patient-derived orthotopic xenograft (PDOX) model.

Materials And Methods: The PDOX model was established in the left 2 mammary by surgical orthotopic implantation (SOI). Read More

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http://dx.doi.org/10.21873/anticanres.14217DOI Listing

De-differentiation of papillary thyroid carcinoma into squamous cell carcinoma in an elderly patient: A case report.

Medicine (Baltimore) 2020 Apr;99(16):e19892

Diabetes and Thyroid Center, Theptarin Hospital.

Rationale: The unpredictability of thyroid cancer can be striking, as the disease may rapidly progress to death in some individuals. Herein, we reported a rare case of aggressive papillary thyroid cell carcinoma (PTC) in an elderly patient de-differentiated into squamous cell carcinoma (SCC).

Patient Concerns: We describe a case of a 79-year-old Thai woman presented with hoarseness and neck mass for 2 months and she had been diagnosed with a 3-cm papillary thyroid carcinoma (PTC) in the right side of the thyroid gland. Read More

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http://dx.doi.org/10.1097/MD.0000000000019892DOI Listing

Fine-needle aspiration with rapid parathyroid hormone assay to identify parathyroid gland in thyroidectomy.

Medicine (Baltimore) 2020 Apr;99(16):e19840

Department of Nuclear Medicine, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai, China.

To determine the levels of parathyroid hormone (PTH) in the fluids of various tissues for identification of parathyroid glands during thyroidectomy.Our study comprised 31 patients with thyroid cancer who underwent lobectomy with central compartment dissection at our hospital from October 2014 to February 2015. A total of 186 tissue samples, including 28 from parathyroid glands and 158 from non-parathyroid tissues, were obtained during the operations. Read More

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http://dx.doi.org/10.1097/MD.0000000000019840DOI Listing

Prediction mode of more than 5 central lymph nodes metastases in clinically node-negative ipsilateral papillary thyroid carcinoma with tumor size 1 to 4 cm.

Medicine (Baltimore) 2020 Apr;99(16):e19809

Department of Head and Neck Surgery.

According to the 2015 American Thyroid Association guidelines, either lobectomy or total thyroidectomy was recommended for patients with papillary thyroid carcinoma (PTC) of 1 to 4 cm without extrathyroidal extension and lymph node metastasis. However, lymph node metastases showed strong association with recurrence and low survival rate, especially in PTC patients with more than 5 metastatic lymph nodes. Therefore, this study aimed to investigate the predictive factors of more than 5 central lymph nodes metastases (CLNM) in PTC patients with tumor sizes of 1 to 4 cm. Read More

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http://dx.doi.org/10.1097/MD.0000000000019809DOI Listing

The effect of preterm birth, recurrent laryngeal nerve lesion, and postnatal maturation on hyoid and thyroid movements, and their coordination in infant feeding.

J Biomech 2020 May 12;105:109786. Epub 2020 Apr 12.

Department of Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, OH, 44272, United States.

Movements of the hyoid and thyroid are critical for feeding. These structures are often assumed to move in synchrony, despite evidence that neurologically compromised populations exhibit altered kinematics. Preterm infants are widely considered to be a neurologically compromised population and often experience feeding difficulties, yet measuring performance, and how performance matures in pediatric populations is challenging. Read More

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http://dx.doi.org/10.1016/j.jbiomech.2020.109786DOI Listing
May 2020
2.751 Impact Factor

Cytological diagnosis of a rare synchronous non-small cell lung cancer metastatic to the thyroid gland.

Cytopathology 2020 Apr 14. Epub 2020 Apr 14.

Operative Unit of Pathologic Anatomy, Azienda USL della Romagna, Infermi Hospital of Rimini, Rimini, Italy.

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http://dx.doi.org/10.1111/cyt.12832DOI Listing

Silicone tubes with thyroid hormone (Τ3) and BDNF as an alternative to autografts for bridging neural defects.

Injury 2020 Apr 6. Epub 2020 Apr 6.

Laboratory of Education & Research in Neuroscience (LERNs), Department of Anatomy, National & Kapodistrian University of Athens, Greece; School of Medicine, European University Cyprus, Cyprus.

The way thyroid hormone works in peripheral nerve regeneration has not been fully elucidated, although studies have shown that it has a strong positive effect on nerve regeneration. It is argued that its action is probably stronger than the neurotrophic factors that have been used for some time. It is hypothesized that the use of thyroid hormone in the nerve tubes has a beneficial effect on nerve regeneration to the extent that the results of its use are comparable to those of the autograft technique in bridging small nerve deficits. Read More

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http://dx.doi.org/10.1016/j.injury.2020.03.026DOI Listing

Clinicopathologic characteristics and outcomes of papillary thyroid carcinoma in younger patients.

Medicine (Baltimore) 2020 Apr;99(15):e19795

Department of Integrated Chinese and Western Medicine, Institute of cancer research and basic medical sciences of Chinese Academy of Sciences, Cancer hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital.

In the 7th edition of AJCC staging system, cervical lymph node metastases (LNM) in papillary thyroid carcinoma (PTC) is considered as a poorer prognostic indicator only in patients aged 45 years or older, but as a low-risk factor in patients younger than 45 years. The objective of this study is to investigate the influence of cervical LNM on prognostic outcomes of young patients (<45 years' old) with PTC.We carried out a retrospective analysis of 1896 PTC patients younger than 45 years' old at diagnosis, who were firstly treated in our department between January 2005 and December 2014. Read More

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http://dx.doi.org/10.1097/MD.0000000000019795DOI Listing

[Spinalcord compression secondary to metastases from a non-previous diagnosed thyroid cancer].

Rev Med Liege 2020 04;75(4):201-202

Service de Médecine Interne, Diabète et Maladies Métaboliques, Hôpitaux Universitaires de Strasbourg, France.

We presented a case of a 73-year-old woman presenting to the emergency department with a spinal cord compression secondary to a T2 mass lesion and needing emergency surgery. The lesion was consistent with a papillary thyroid carcinoma. The patient had a previous history of thyroidectomy in a setting of a multinodular goiter 6 years before. Read More

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Thyroid Tubercle of Zuckerkandl May Not Arise from the Ultimobranchial Body: Results from Histological Analysis.

Pathobiology 2020 Apr 6:1-5. Epub 2020 Apr 6.

Department of Surgery, Kuma Hospital, Kobe, Japan.

Thyroid tubercle of Zuckerkandl (TZ) is a nodule arising from the posterolateral thyroid, considered to be a remnant of the ultimobranchial body (UB). Considering that C cells and solid cell nests also arise from the UB, we hypothesized that these would be present in the TZ. We examined the presence of C cells and solid cell nests in the TZ using the histological analyses of 21 patients with grade 2 or 3 TZs following Pelizzo's grading system. Read More

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http://dx.doi.org/10.1159/000506231DOI Listing

Optimization of serum thyroglobulin measured at different time points for prognostic evaluation in differentiated thyroid carcinoma patients.

Medicine (Baltimore) 2020 Apr;99(14):e19652

Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, Jeonnam, Republic of Korea.

Although serum thyroglobulin (Tg) is a reliable differentiated thyroid carcinoma (DTC) prognostic marker, its cutoff values can be affected by TSH stimulation status. Serum Tg prognostic values measured at different time points before and after radioactive iodine (RAI) therapy prepared with recombinant human TSH (rhTSH) in DTC patients, were investigated.This study included 160 DTC patients who underwent surgery followed by rhTSH-aided RAI therapy. Read More

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http://dx.doi.org/10.1097/MD.0000000000019652DOI Listing

Maintenance of neural stem cell positional identity by .

Science 2020 04;368(6486):48-53

Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.

Neural stem cells (NSCs) in the developing and postnatal brain have distinct positional identities that dictate the types of neurons they generate. Although morphogens initially establish NSC positional identity in the neural tube, it is unclear how such regional differences are maintained as the forebrain grows much larger and more anatomically complex. We found that the maintenance of NSC positional identity in the murine brain requires a ()-dependent epigenetic memory system. Read More

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http://dx.doi.org/10.1126/science.aba5960DOI Listing

Connection between SOX7 Expression and Breast Cancer Prognosis.

Med Sci Monit 2020 Apr 2;26:e921510. Epub 2020 Apr 2.

Department of Thyroid Breast Surgery, Weihai Municipal Hospital, Weihai, Shandong, China (mainland).

BACKGROUND SOX7 exerts a repressing effect against tumors and imposes vital influences on malignancies. Our research discussed the importance of SOX7 in breast cancer prognoses. MATERIAL AND METHODS SOX7 mRNA expression in breast cancer tissues samples and matched adjacent normal controls of breast cancer patients was measured by quantitative real-time-polymerase chain reaction (qRT-PCR). Read More

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http://dx.doi.org/10.12659/MSM.921510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152737PMC

Cholestatic syndrome as initial manifestation of pancreatic metastasis of papillary thyroid carcinoma: case report and review.

Arch Endocrinol Metab 2020 Apr 27;64(2):179-184. Epub 2020 Mar 27.

Unidade de Endocrinologia Oncológica, Instituto Nacional de Câncer José Alencar Gomes da Silva, Rio de Janeiro, RJ, Brasil.

Most papillary thyroid carcinomas (PTC) harbor excellent prognosis. Although rare, distant metastases normally occur in lungs and/or bones. Here we describe a rare case of pancreatic metastasis presenting with rapid onset cholestatic syndrome. Read More

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http://dx.doi.org/10.20945/2359-3997000000215DOI Listing

Microscopic extrathyroid extension in papillary thyroid carcinoma: impact on response to therapy.

Arch Endocrinol Metab 2020 Apr 27;64(2):144-149. Epub 2020 Mar 27.

Endocrinology Department, Instituto Português de Oncologia de Coimbra Francisco Gentil, EPE, Coimbra, Portugal.

Objectives Evaluate the impact of microscopic extrathyroid extension (MEE) on outcome and therapy response in patients with cT1 and cT2 papillary thyroid carcinoma (PTC). Subjects and methods Retrospective study of 970 consecutive patients, who underwent surgery for PTC between 2000 and 2016. All patients had: tumours ≤ 4 cm, apparent complete tumour resection, without clinically apparent lymph node or distant metastasis at diagnosis and nonaggressive histologic variant. Read More

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http://dx.doi.org/10.20945/2359-3997000000210DOI Listing

Aspiration with or without lavage in the treatment of acute suppurative thyroiditis secondary to pyriform sinus fistula.

Arch Endocrinol Metab 2020 Apr 27;64(2):128-137. Epub 2020 Mar 27.

Department of Otolaryngology, Affiliated Changzhou No. 2 People's Hospital, Nanjing Medical University, Changzhou, Jiangsu, China.

Objective There is currently no consensus regarding the optimal management of acute suppurative thyroiditis (AST) secondary to pyriform sinus fistula (PSF). To investigate the benefits and adverse events of aspiration with or without lavage for the treatment of AST secondary to PSF. Subjects and methods This was a retrospective analysis of consecutive patients with AST secondary to PSF who were admitted at the Affiliated Changzhou No. Read More

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http://dx.doi.org/10.20945/2359-3997000000207DOI Listing

Combinatorial Therapies in Thyroid Cancer: An Overview of Preclinical and Clinical Progresses.

Cells 2020 Mar 30;9(4). Epub 2020 Mar 30.

Laboratory of Human Anatomy and Experimental Oncology, Faculty of Medicine, Mons University, Avenue du Champ de Mars, 8, B7000 Mons, Belgium.

Accounting for about 2% of cancers diagnosed worldwide, thyroid cancer has caused about 41,000 deaths in 2018. Despite significant progresses made in recent decades in the treatment of thyroid cancer, many resistances to current monotherapies are observed. In our complete review, we report all treatments that were tested in combination against thyroid cancer. Read More

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http://dx.doi.org/10.3390/cells9040830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226736PMC

MANAGEMENT OF ENDOCRINE DISEASE: Female sexual dysfunction for the endocrinologist.

Eur J Endocrinol 2020 Jun;182(6):R101

Chair in Endocrinology and Medical Sexology (ENDOSEX), Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Sexual function is an important component of either general health and quality of life in both genders. Many studies have focused on the different risk factors for sexual dysfunctions, proving an association with several medical conditions. Endocrine disorders have been often mentioned in the pathogenesis of female and male sexual dysfunctions; however, particularly in women, sexual function is rarely addressed during clinical, in general, and endocrinological, in particular, consultations. Read More

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http://dx.doi.org/10.1530/EJE-19-0903DOI Listing

Association of Triiodothyronine Levels With Prostate Cancer Histopathological Differentiation and Tumor Stage.

Anticancer Res 2020 Apr;40(4):2323-2329

Department of Oncology and Nuclear Medicine, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia.

Background/aim: The aim of this study was to determine the association between total triiodothyronine (T3), free fraction of thyroxin (FT4), and thyrotropin (TSH) levels with prostate cancer histopathological features.

Patients And Methods: Blood samples from 140 patients with prostate cancer were analyzed preoperatively and stratified according to postoperative histopathological differentiation. The first group (N=62) included patients with prostate cancer Grade Groups (GG) 1-2, while the second group (N=63) included patients with prostate cancer GG 3-5. Read More

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http://dx.doi.org/10.21873/anticanres.14199DOI Listing

Papillary thyroid microcarcinoma presenting as a metastasis to the brain.

Ann R Coll Surg Engl 2020 May 1;102(5):e107-e110. Epub 2020 Apr 1.

Centre for Endocrine Surgery, University College London Hospital, London, UK.

The brain is a particularly rare site of metastasis from papillary microcarcinoma, with only few cases described in the literature. We present a case of 59-year-old man who presented with seizures and dysphasia due to left frontal lobe cystic mass, which was excised and turned out on histopathology to be of thyroid origin. Total thyroidectomy was performed and histology showed multifocal papillary microcarcinoma with the largest focus of 3mm with no other adverse features. Read More

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http://dx.doi.org/10.1308/rcsann.2020.0041DOI Listing

A Diagnostic Dilemma: Skip Metastasis in Papillary Thyroid Cancer.

Am Surg 2020 Mar;86(3):245-249

The frequency, pattern, and predictive factors for skip LN metastasis in patients with papillary thyroid carcinoma (PTC) remain controversial. In this study, we evaluated predictive factors of skip LN metastasis in these patients. We reviewed the medical records of 68 PTC patients who underwent total thyroidectomy, central neck dissection, and lateral neck dissection at the initial operation. Read More

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Neurotized Free Platysma Flap for Functional Eyelid Reconstruction: A Cadaveric Study of Anatomical Feasibility.

Plast Reconstr Surg 2020 Apr;145(4):1049-1057

Chicago, Ill.; and Cleveland, Ohio From the Division of Plastic and Reconstructive Surgery, Northwestern Feinberg School of Medicine; and the Department of Plastic Surgery, Cleveland Clinic.

Background: Conventional reconstructive options for large full-thickness eyelid defects are limited to static local flaps without replacing the missing orbicularis. The authors' aim is to delineate the platysma neurovascular anatomy for innervated functional eyelid reconstruction.

Methods: Fourteen fresh latex-injected heminecks were dissected. Read More

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http://dx.doi.org/10.1097/PRS.0000000000006648DOI Listing

[Analysis of Collision Carcinoma of Larynx Between Moderately Differentiated Squamous Cell Carcinoma and Poorly Differentiated Neuroendocrine Carcinoma from One Case].

Sichuan Da Xue Xue Bao Yi Xue Ban 2020 Mar;51(2):261-263

Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.

A 75-year-old male patient was hospitalized in hoarseness for 2 months. Laryngoscopy showed a mass protruding in right laryngeal chamber and covering the middle part of right vocal cord. Since tumor biopsy showed low differentiation cancer, he received total laryngectomy, and post-operative pathological result found composite carcinoma, which containing medium differentiated squamous cell carcinoma (about 5%) and low differentiated neuroendocrine carcinoma (about 95%). Read More

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http://dx.doi.org/10.12182/20200360202DOI Listing

Lymph node metastasis around the entrance point to recurrent laryngeal nerve in papillary thyroid carcinoma.

Sci Rep 2020 Mar 25;10(1):5433. Epub 2020 Mar 25.

Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

There are few reports on the lymph nodes of entrance point to recurrent laryngeal nerve (LN-epRLN) in patients with papillary thyroid carcinoma (PTC). Thus, we investigated the clinical significance of LN-epRLN and implications it may have. An observational analysis of 878 consecutive patients with PTC who underwent thyroidectomy from April 2016 to March 2017 was conducted. Read More

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http://dx.doi.org/10.1038/s41598-020-62031-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096401PMC

DNA-BINDING and DNA-protecting activities of small natural organic molecules and food extracts.

Chem Biol Interact 2020 May 20;323:109030. Epub 2020 Mar 20.

Department of Pathobiology, Faculty of Pharmacy, University of Belgrade, Serbia.

The review summarizes literature data on the DNA-binding, DNA-protecting and DNA-damaging activities of a range of natural human endogenous and exogenous compounds. Small natural organic molecules bind DNA in a site-specific mode, by arranging tight touch with the structure of the major and minor grooves, as well as individual bases in the local duplex DNA. Polyphenols are the best-studied exogenous compounds from this point of view. Read More

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http://dx.doi.org/10.1016/j.cbi.2020.109030DOI Listing

Di-(2-ethylhexyl) phthalate inhibits expression and internalization of transthyretin in human placental trophoblastic cells.

Toxicol Appl Pharmacol 2020 May 20;394:114960. Epub 2020 Mar 20.

Department of Toxicology, Anhui Medical University, No 81 Meishan Road, Hefei 230032, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes/Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, No 81 Meishan Road, Hefei 230032, China. Electronic address:

During pregnancy, fetal thyroid hormones (THs) are dependent on maternal placental transport and their physiological level is crucial for normal fetal neurodevelopment. Earlier research has shown that Di-(2-ethylhexyl) phthalate (DEHP) disrupts thyroid function and THs homeostasis in pregnant women and fetuses, and affects placental THs transport. However, the underlying mechanisms are poorly understood. Read More

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http://dx.doi.org/10.1016/j.taap.2020.114960DOI Listing

The significance of Runx2 mediating alcohol-induced Brf1 expression and RNA Pol III gene transcription.

Chem Biol Interact 2020 May 18;323:109057. Epub 2020 Mar 18.

Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address:

Runx2 (Runt-related transcription factor 2) is a key transcription factor which is associated with osteoblast differentiation and expressed in ER+ (estrogen receptor positive) human breast cancer cell lines. Runx2 also participates in mammary gland development. Deregulation of RNA Pol III genes (polymerase III-dependent genes) is tightly linked to tumor development, while Brf1 (TFIIB-related factor 1) specifically regulates these gene transcription. Read More

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http://dx.doi.org/10.1016/j.cbi.2020.109057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261693PMC

Over expression of CDK4 and MDM2 in a patient with recurrent ALK-negative mediastinal inflammatory myofibroblastic tumor: A case report.

Medicine (Baltimore) 2020 Mar;99(12):e19577

Division of Hematology and Medical Oncology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan.

Rationale: The diagnosis of anaplastic lymphoma kinase (ALK)-negative inflammatory myofibroblastic tumors (IMT) remains challenging because of their morphological resemblance with spindle cell sarcoma with myofibroblastic characteristics.

Patient Concerns: A 69-year-old female patient presented with loco-regional recurrent IMT several times within 8 years after primary treatment and neck lymph node metastasis 3.5 years after last recurrence. Read More

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http://dx.doi.org/10.1097/MD.0000000000019577DOI Listing

The Impact of Arterial Phase on the Detection of Cervical Lymph Node Metastasis From Papillary Thyroid Carcinoma: A Quantitative Evaluation on Multiphasic Computed Tomography.

J Comput Assist Tomogr 2020 Mar/Apr;44(2):262-268

Otorhinolaringology, School of Medicine, Ankara University, Ankara, Turkey.

Objective: The purpose of this study was to assess the diagnostic performance of multiphasic computed tomography (CT) in the discrimination of metastatic lymph nodes (LNs) of papillary thyroid cancer by using quantitative parameters.

Methods: This study enrolled 272 pathologically proven metastatic and benign LNs. Multiphasic CT was utilized by using nonenhanced, arterial (25-second delay), and venous (80-second delay) phases. Read More

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http://dx.doi.org/10.1097/RCT.0000000000001005DOI Listing

Low-risk papillary thyroid microcarcinoma: Optimal management toward a more conservative approach.

J Surg Oncol 2020 May 18;121(6):958-963. Epub 2020 Mar 18.

Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.

The incidence of papillary thyroid microcarcinoma (microPTC) has dramatically increased in the last decades. Most of these tumors remain small and clinically "silent", only small number progress. Although thyroid surgery used to be the only therapeutic approach, recent guidelines now consider active surveillance for low-risk microPTC. Read More

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http://dx.doi.org/10.1002/jso.25848DOI Listing
May 2020
3.244 Impact Factor

Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition.

Arch Endocrinol Metab 2020 Feb 13;64(1):89-95. Epub 2020 Mar 13.

Departamento de Pós-Graduação em Distúrbios do Desenvolvimento, Centro de Ciências Biológicas e da Saúde, Universidade Presbiteriana Mackenzie, São Paulo, SP, Brasil.

Clinical and subclinical hypothyroidism are the most common hormonal dysfunctions during pregnancy. Insufficient maternal thyroid hormones (THs) in the early stages of pregnancy can lead to severe impairments in the development of the central nervous system because THs are critical to central nervous system development. In the fetus and after birth, THs participate in neurogenic processes, cell differentiation, neuronal activation, axonal growth, dendritic arborization, synaptogenesis and myelination. Read More

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http://dx.doi.org/10.20945/2359-3997000000201DOI Listing
February 2020

Molecular Imaging of Galectin-1 Expression as a Biomarker of Papillary Thyroid Cancer by Using Peptide-Functionalized Imaging Probes.

Biology (Basel) 2020 Mar 14;9(3). Epub 2020 Mar 14.

Department of General, Organic and Biomedical Chemistry, UMONS, Avenue Victor Maistriau 19, 7000 Mons, Belgium.

Thyroid cancers are the most frequent endocrine cancers and their incidence is increasing worldwide. Thyroid nodules occur in over 19-68% of the population, but only 7-15% of them are diagnosed as malignant. Diagnosis relies on a fine needle aspiration biopsy, which is often inconclusive and about 90% of thyroidectomies are performed for benign lesions. Read More

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http://dx.doi.org/10.3390/biology9030053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150867PMC

The Expression, Clinicopathologic Characteristics, and Prognostic Value of Androgen Receptor in Breast Cancer: A Bioinformatics Analysis Using Public Databases.

DNA Cell Biol 2020 May 16;39(5):864-874. Epub 2020 Mar 16.

Department of Breast Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, China.

The role of androgen receptor () in breast cancer has been unveiled in succession for the past few years. In this study, we conducted a comprehensive analysis based on four online public databases of data from many previous studies. We found that the expression of is significantly related to age, histological grade, and subtype but not to lymph node status. Read More

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http://dx.doi.org/10.1089/dna.2019.5192DOI Listing

Male axillary accessory breast cancer: A case report.

Medicine (Baltimore) 2020 Mar;99(11):e19506

General Surgery, Qingdao West Coast New Area Central Hospital, Qingdao, China.

Rationale: Accessory breast cancer is extremely rare among all cancerous diseases, especially in male patients. There were only few male axillary accessory breast cancer cases that have been reported in scientific literatures so far. Hereby, we would like to discuss a case of male axillary accessory breast cancer found in our hospital. Read More

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http://dx.doi.org/10.1097/MD.0000000000019506DOI Listing

Rapid disease progression after discontinuation of lenvatinib in thyroid cancer.

Medicine (Baltimore) 2020 Mar;99(11):e19408

Department of Surgery, Ito Hospital, 4-3-6, Jingumae, Shibuya-ku, Tokyo.

Some thyroid cancer patients experience a rapid disease progression after the discontinuation of tyrosine kinase inhibitors (TKIs), which is called flare phenomenon. The incidence of the flare phenomenon of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) ranged from 4% to 11.1% and the median time to occurrence of the flare phenomenon ranged from 7 to 12 days in previous reports. Read More

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http://dx.doi.org/10.1097/MD.0000000000019408DOI Listing

[Thyrotropin-secreting pituitary adenoma].

Orv Hetil 2020 Mar;161(12):474-478

I. Belgyógyászati és Infektológiai Osztály, Zala Megyei Szent Rafael Kórház Zalaegerszeg, Zrínyi M. út 1., 8900.

Thyrotropin-secreting pituitary tumors are rare causes of hyperthyroidism and account for less than 1% of all pituitary adenomas. The number of reported cases increased over the last few years as a consequence of the routine use of ultrasensitive immunometric assays for measuring thyrotropin levels. In the clinical practice, thyrotropin secreting adenomas must be considered in case of inappropriately normal to elevated thyrotropin in the presence of elevated free serum thyroid hormone levels. Read More

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http://dx.doi.org/10.1556/650.2020.31697DOI Listing

[A pathological report of three COVID-19 cases by minimal invasive autopsies].

Zhonghua Bing Li Xue Za Zhi 2020 May;49(5):411-417

Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.

To investigate the pathological characteristics and the clinical significance of novel coronavirus (2019-nCoV)-infected pneumonia (termed by WHO as coronavirus disease 2019, COVID-19). Minimally invasive autopsies from lung, heart, kidney, spleen, bone marrow, liver, pancreas, stomach, intestine, thyroid and skin were performed on three patients died of novel coronavirus pneumonia in Chongqing, China. Hematoxylin and eosin staining (HE), transmission electron microcopy, and histochemical staining were performed to investigate the pathological changes of indicated organs or tissues. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20200312-00193DOI Listing

Thyroid carcinoma with atypical metastasis to the pituitary gland and unexpected postmortal diagnosis.

Endocrinol Diabetes Metab Case Rep 2020 Mar 13;2020. Epub 2020 Mar 13.

Departments of Endocrinology, Diabetology and Internal Medicine.

Summary: Papillary thyroid gland carcinoma is the most common type of malignancy of the endocrine system. Metastases to the pituitary gland have been described as a complication of papillary thyroid cancer in few reported cases since 1965. We report the case of a 68-year-old female patient with a well-differentiated form of thyroid gland cancer. Read More

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http://dx.doi.org/10.1530/EDM-19-0148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077587PMC

Ensemble disease gene prediction by clinical sample-based networks.

BMC Bioinformatics 2020 Mar 11;21(Suppl 2):79. Epub 2020 Mar 11.

Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, S7N 5A9, Canada.

Background: Disease gene prediction is a critical and challenging task. Many computational methods have been developed to predict disease genes, which can reduce the money and time used in the experimental validation. Since proteins (products of genes) usually work together to achieve a specific function, biomolecular networks, such as the protein-protein interaction (PPI) network and gene co-expression networks, are widely used to predict disease genes by analyzing the relationships between known disease genes and other genes in the networks. Read More

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http://dx.doi.org/10.1186/s12859-020-3346-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068856PMC
March 2020
2.576 Impact Factor