58,844 results match your criteria Thyroid Anatomy


Sistrunk centennial: Evolution of a classic operation.

Authors:
Glenn Isaacson

Laryngoscope 2019 Mar 19. Epub 2019 Mar 19.

Department of Otolaryngology -Head and Neck Surgery and Department of Pediatrics, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, U.S.A.

Objectives/hypothesis: To trace the evolution of the Sistrunk procedure.

Study Design: Historical review.

Methods: We reviewed historical materials in the English, French, and German literature including journal articles, book chapters, genealogical sources, and obituaries to identify the emerging concepts leading to the Sistrunk operation. Read More

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http://dx.doi.org/10.1002/lary.27914DOI Listing

Modulation of Mitochondrial ERβ Expression Inhibits Triple-Negative Breast Cancer Tumor Progression by Activating Mitochondrial Function.

Cell Physiol Biochem 2019 15;52(3):468-485. Epub 2019 Mar 15.

Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea,

Background/aims: Breast cancer is a clinically and molecularly heterogeneous disease. Patients with triple-negative breast cancer (TNBC) have poorer outcomes than those with other breast cancer subtypes due to lack of effective molecular targets for therapy. The present study aimed to the identification of estrogen receptor (ER)β as a novel mitochondrial target in TNBC cells, together with underlying mechanisms. Read More

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http://dx.doi.org/10.33594/000000034DOI Listing
March 2019
1 Read

RISK OF MALIGNANCY IN THYROID CYTOLOGY: THE IMPACT OF THE RECLASSIFICATION OF NONINVASIVE FOLLICULAR THYROID NEOPLASM WITH PAPILLARY-LIKE NUCLEAR FEATURES (NIFTP).

Endocr Pract 2019 Mar 13. Epub 2019 Mar 13.

From: 1Endocrinology, Diabetes and Metabolism Department, University and Hospital Center of Coimbra, Coimbra, Portugal.

Objectives: Non-invasive encapsulated follicular variant of papillary thyroid carcinoma (NEFVPTC) was recently reclassified as non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). We aimed to compare the risk of malignancy (ROM) of the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) on fine-needle aspiration cytology (FNAC), before and after the reclassification, in a large cohort of patients.

Methods: We analyzed 5. Read More

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http://dx.doi.org/10.4158/EP-2018-0423DOI Listing
March 2019
1 Read

Targeting high transcriptional control activity of long mononucleotide A-T repeats in cancer by Argonaute 1.

Gene 2019 Mar 9;699:54-61. Epub 2019 Mar 9.

Center of Excellence in Molecular Genetic of Cancer and Human Disease, Department of Anatomy, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand. Electronic address:

Epigenetic regulatory changes alter the gene regulation function of DNA repeat elements in cancer and consequently promote malignant phenotypes. Some short tandem repeat sequences, distributed throughout the human genome, can play a role as cis-regulatory elements of the genes. Distributions of tandem long (≥10) and short (<10) A-T repeats in the genome are different depending on gene functions. Read More

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http://dx.doi.org/10.1016/j.gene.2019.03.010DOI Listing
March 2019
2 Reads

A Method for Reconstruction of Anterior Commissure Glottal Webs With Endoscopic Fibro-Mucosal Flaps.

Ann Otol Rhinol Laryngol 2019 Mar;128(3_suppl):82S-93S

1 Department of Surgery, Harvard Medical School, Boston, MA, USA.

Background:: Anterior-commissure (AC) cicatrization and web formation is a difficult problem that can result from a variety of clinical scenarios. An advancement-rotation flap utilizing papillomatous epithelium and subepithelial fibrous tissue has been previously described. For patients in whom there was not excessive redundant papillomatosis covering the AC web, including other clinical scenarios, a microlaryngoscopic procedure was designed to lengthen the glottal/subglottal aperture using substantial local fibro-mucosal tissue. Read More

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http://dx.doi.org/10.1177/0003489418820031DOI Listing
March 2019
2 Reads

TEK is a novel prognostic marker for clear cell renal cell carcinoma.

Eur Rev Med Pharmacol Sci 2019 Feb;23(4):1451-1458

Department of Anatomy, Pusan National University School of Medicine, Yangsan, Republic of Korea.

Objective: Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. However, effective therapeutics for ccRCC are lacking. Novel biomarkers could provide critical information when determining prognoses for patients with ccRCC. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17102DOI Listing
February 2019
2 Reads

Tobacco chemical-induced mouse lung adenocarcinoma cell lines pin the prolactin orthologue proliferin as a lung tumour promoter.

Carcinogenesis 2019 Mar 4. Epub 2019 Mar 4.

Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine; University of Patras; Rio, Achaia, Greece.

Lung adenocarcinoma (LADC) is the leading cause of cancer death worldwide. Nevertheless, syngeneic mouse models of the disease are sparse, and cell lines suitable for transplantable and immunocompetent mouse models of LADC remain unmet needs. We established multiple mouse LADC cell lines by repeatedly exposing two mouse strains (FVB, Balb/c) to the tobacco carcinogens urethane or diethylnitrosamine and by culturing out the resulting lung tumors for prolonged periods of time. Read More

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http://dx.doi.org/10.1093/carcin/bgz047DOI Listing
March 2019
1 Read

A case report of a giant mature teratoma of the thyroid gland in a young girl.

Medicine (Baltimore) 2019 Mar;98(9):e14703

Rationale: Teratomas are extremely rare in the thyroid gland. A cervical teratoma presenting as a cystic or mixed thyroid lesion can be easily confused with a thyroglossal duct cyst. It is difficult for pediatricians to differentiate between these 2 types of lesions. Read More

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http://dx.doi.org/10.1097/MD.0000000000014703DOI Listing
March 2019
1 Read

TNF‑α inhibits xenograft tumor formation by A549 lung cancer cells in nude mice via the HIF‑1α/VASP signaling pathway.

Oncol Rep 2019 Feb 21. Epub 2019 Feb 21.

Department of Breast and Thyroid Surgery, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan, Hubei 430071, P.R. China.

Lung cancer is the leading cause of cancer‑associated mortality worldwide. Tumor necrosis factor α (TNF‑α) is an important cytokine in the tumor microenvironment that serves a function in the balance of cell survival and cell death pathways. Our previous studies indicated that hypoxia‑inducible factor 1α (HIF‑1α) acts downstream of TNF‑α in MCF‑7 luminal breast cancer cells. Read More

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http://dx.doi.org/10.3892/or.2019.7026DOI Listing
February 2019
1 Read

Upregulated tissue expression of T helper (Th) 17 pathogenic interleukin (IL)-23 and IL-1β in Hashimoto's thyroiditis but not in Graves' disease.

Endocr J 2019 Feb 27. Epub 2019 Feb 27.

Institute of Anatomy and Anthropology, Riga Stradins University, Riga, LV-1010, Latvia.

T helper (Th) 17 cells and interleukin (IL)-17 play a significant role in the pathogenesis of autoimmune thyroid disease (AITD). However, it has recently become clear that Th17 cells are more heterogeneous and exhibit two different phenotypes, whereas IL-23 and IL-1β are crucial for the generation of pathogenic Th17 lymphocytes. We aimed to investigate the association between IL-17 and Th17-promoting cytokines in AITD by studying the immunoexpression patterns of IL-17, IL-23, and IL-1β in thyroid tissue. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0396DOI Listing
February 2019
1 Read

Diffuse alveolar hemorrhage in a patient with ANCA-associated vasculitis after thyroidectomy: A case report.

Medicine (Baltimore) 2019 Feb;98(8):e14630

Department of Anesthesiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.

Rationale: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune disease that mainly affects the lungs and kidneys. Limited reports of perioperative management of such patients were primarily concerned with airway stenosis. Here, we report a patient with AAV who developed diffuse alveolar hemorrhage (DAH) early after radical thyroidectomy. Read More

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http://dx.doi.org/10.1097/MD.0000000000014630DOI Listing
February 2019
1 Read

A case report of 131I therapy for Graves' disease patient with hemiagenesis.

Medicine (Baltimore) 2019 Feb;98(8):e14606

Department of Nuclear Medicine, Third Central Hospital of Tianjin, Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Technology Research Center of Public Health Ministry.

Rationale: Thyroid hemiagenesis is a rare congenital dysplasia, whereas a variety of pathological changes may occur in residual thyroid lobe. The most frequently described pathology in residual thyroid lobe is Graves' hyperthyroidism. Although I therapy has been generally recommended as the preferred treatment for Graves' disease (GD), subjects relating to hemiagenesis are very limited, especially in China. Read More

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http://dx.doi.org/10.1097/MD.0000000000014606DOI Listing
February 2019
4 Reads

MCNP SIMULATIONS WITH A PERSONALISED VOXEL PHANTOM TO VERIFY 131I CONTENT IN THYROID ESTIMATED BASED ON MEASUREMENTS WITH AN NaI(Tl) SPECTROMETER.

Radiat Prot Dosimetry 2019 Feb 26. Epub 2019 Feb 26.

Department of Radiation Measurement and Dose Assessment, National Institutes for Quantum and Radiological Sciences and Technology, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba-city, Chiba, Japan.

One of the authors (O.K.) stayed in the area located ~110 km south from the Fukushima Daiichi Nuclear Power Plant during the arrival of radioactive plumes released into the environment due to the accident in March 2011 in Japan. Read More

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http://dx.doi.org/10.1093/rpd/ncz020DOI Listing
February 2019

Chlorotoxin targets ERα/VASP signaling pathway to combat breast cancer.

Cancer Med 2019 Feb 25. Epub 2019 Feb 25.

Department of Pathology and Pathophysiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, China.

Breast cancer is one of the most common malignant tumors among women worldwide. About 70-75% of primary breast cancers belong to estrogen receptor (ER)-positive breast cancer. In the development of ER-positive breast cancer, abnormal activation of the ERα pathway plays an important role and is also a key point leading to the failure of clinical endocrine therapy. Read More

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http://dx.doi.org/10.1002/cam4.2019DOI Listing
February 2019

The Impact of Esophageal Compression on Goiter Symptoms before and after Thyroid Surgery.

Eur Thyroid J 2019 Jan 17;8(1):16-23. Epub 2018 Oct 17.

Department of ORL Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.

Introduction: Benign nodular goiter may be associated with swallowing difficulties, but insight into the associated pathophysiology is limited. The aim of this study was to investigate the effect of surgery on the degree of esophageal compression, and its correlation to swallowing difficulties.

Methods: Esophageal compression and deviation were evaluated blindly on magnetic resonance imaging (MRI) of the neck, prior to and 6 months after thyroid surgery for symptomatic benign goiter. Read More

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http://dx.doi.org/10.1159/000493542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381902PMC
January 2019
1 Read

Origin of superior thyroid artery: under the surgeon's knife.

J Vasc Bras 2018 Oct-Dec;17(4):290-295

Kasturba Medical College, Department of Anatomy, Manipal, Karnataka, India.

Background: The major arterial supply to the thyroid gland is from the superior and inferior thyroid arteries, arising from the external carotid artery and the thyrocervical trunk respectively. The external laryngeal nerve runs in close proximity to the origin of the superior thyroid artery in relation to the thyroid gland. The superior thyroid artery is clinically important in head and neck surgeries. Read More

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http://dx.doi.org/10.1590/1677-5449.004218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375267PMC
February 2019

Ultrasonographic study of the incidence of pyramidal lobe and agenesis of the thyroid isthmus in Nnewi population.

J Ultrason 2018 ;18(75):290-295

Department of Microbiology, Odumegwu Ojoukwu University , Uli, Anambra State , Nigeria.

Ultrasound is the most reliable imaging modality for thyroid evaluation due to the limitations in the clinical examination of this gland. Thyroid gland developmental anomalies are rare. Most of its variations are due to the persistence of the thyroglossal duct and the absence of the isthmus. Read More

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http://dx.doi.org/10.15557/JoU.2018.0042DOI Listing
January 2018

Local recurrence of sinonasal renal cell-like adenocarcinoma: A CARE compliant case report.

Medicine (Baltimore) 2019 Feb;98(7):e14533

Department of Pathology.

Rationale: Sinonasal renal cell-like adenocarcinoma (SNRCLA) is a very rare sino-nasal carcinoma. Because SNRCLA has the same morphological features as other clear cell carcinomas, and some of them also occurred in sinonasal part, it is necessary to differentiate SNRCLA from these tumors.

Patient Concerns: A 42-year-old man presented with complaints of epistaxis for 1 day. Read More

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http://dx.doi.org/10.1097/MD.0000000000014533DOI Listing
February 2019
1 Read

The prevalence and anatomy of parathyroid glands: a meta-analysis with implications for parathyroid surgery.

Langenbecks Arch Surg 2019 Feb 14;404(1):63-70. Epub 2019 Feb 14.

International Evidence-Based Anatomy Working Group, 12 Kopernika St., 31-034, Kraków, Poland.

Purpose: The anatomy of parathyroid glands (PTG) is highly variable in the population. The aim of this study was to conduct a systematic analysis on the prevalence and location of PTG in healthy and hyperparathyroidism (HPT) patients.

Methods: An extensive search of the major electronic databases was conducted to identify all studies that reported relevant data on the number of PTG per patient and location of PTG. Read More

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http://dx.doi.org/10.1007/s00423-019-01751-8DOI Listing
February 2019
2 Reads
2.160 Impact Factor

Is Drainage Necessary for Robotic Thyroidectomy?

Am Surg 2019 Jan;85(1):e66-e68

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January 2019
2 Reads

Overdoses of acetaminophen disrupt the thyroid-liver axis in neonatal rats.

Authors:
R G Ahmed

Endocr Metab Immune Disord Drug Targets 2019 Feb 12. Epub 2019 Feb 12.

Division of Anatomy and Embryology, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Sue. Egypt.

Objective: The objective of the study was to examine the impact of neonatal acetaminophen (APAP; paracetamol) administrations on the thyroid-liver axis in male Wistar rats.

Methods: APAP (100 or 350 mg/kg) was orally administered to neonates from postnatal day (PND) 20 to 40.

Results: Both APAP doses elicited a substantial increase in serum TSH, albumin, AST, ALT, and ALP values, and a profound decrease in serum FT4 and FT3 values at PND 40 relative to those in the control group. Read More

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http://dx.doi.org/10.2174/1871530319666190212165603DOI Listing
February 2019
5 Reads

Enantioselective thyroid disruption in zebrafish embryo-larvae via exposure to environmental concentrations of the chloroacetamide herbicide acetochlor.

Sci Total Environ 2019 Feb 5;653:1140-1148. Epub 2018 Nov 5.

International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.

Acetochlor (ACT) is a chiral chloroacetamide pesticide that has been heavily used around the world, resulting in its residues being frequently found in surface waters. It has been reported that ACT is an endocrine disrupting chemical (EDC) with strong thyroid hormone-disrupting activity in aquatic organisms. However, the enantioselectivity underlying thyroid disruption has yet to be understood. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.037DOI Listing
February 2019
2 Reads

The role of oncostatin M receptor gene polymorphisms in bladder cancer.

World J Surg Oncol 2019 Feb 12;17(1):30. Epub 2019 Feb 12.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, 37# Guoxuexiang Street, Chengdu, 610041, People's Republic of China.

Background: Oncostatin M receptor (OSMR) represents a part of the interleukin-six (IL6) cytokine group that was discovered recently to be closely associated with cell's growth and differentiation, inflammation, and enhancement of metastatic capacity. A comprehensive study suggests a close relationship between OSMR and papillary thyroid cancer, colorectal cancer, breast cancer, and other tumors. However, the relationship between OSMR and bladder cancer has yet to be determined. Read More

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http://dx.doi.org/10.1186/s12957-018-1555-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371456PMC
February 2019
1 Read

The organophosphate pesticide -OP- malathion inducing thyroidal disruptions and failures in the metamorphosis of the Senegalese sole, Solea senegalensis.

BMC Vet Res 2019 Feb 11;15(1):57. Epub 2019 Feb 11.

Instituto de Ciencias Marinas de Andalucía-ICMAN, CSIC Campus Universitario Río San Pedro, 11510, Puerto Real, Cádiz, Spain.

Background: Organophosphate pesticides-OP-, like malathion, can alter the normal functioning of neuro-endocrine systems (e.g., hypothalamus-pituitary-thyroid-HPT- axis), and to interfere on the thyroidal homeostasis. Read More

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http://dx.doi.org/10.1186/s12917-019-1786-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371575PMC
February 2019
1 Read

Effects of surgical and percutaneous tracheotomy on thyroid hormones.

Ann Ital Chir 2019 ;90:10-13

Aim: To evaluate the effects of surgical and percutaneous tracheotomy on thyroid hormones.

Material And Method: Sixty patients with respiratory problems who underwent surgical tracheotomy and percutaneous tracheotomy between December 2012 and December 2016 were divided into 2 groups. FT3, FT4, thyroglobulin and TSH levels of the groups were statistically evaluated preoperatively and postoperatively. Read More

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January 2019

[Familial medullary thyroid carcinoma: case report and literature review.]

Rev Fac Cien Med Univ Nac Cordoba 2018 12 12;75(4):303-309. Epub 2018 Dec 12.

Instituto Nacional de Enfermedades Neoplásicas Universidad Nacional Mayor de San Marcos.

Medullary thyroid carcinoma (MTC) is a malignant tumour of the calcitonin-secreting parafollicular C cells of the thyroid gland. Up to 25% of MTC are associated to pathogenic germinal variants on the proto-oncogene RET (locus 10q11.2), which cause Familial Medullary Thyroid Carcinoma (FMTC) or Multiple Endocrine Neoplasia type 2 (MEN2); genetic conditions inherited with autosomal dominant pattern. Read More

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http://dx.doi.org/10.31053/1853.0605.v75.n4.20947DOI Listing
December 2018
4 Reads

Association of anthropometric markers with globe position: A population-based MRI study.

PLoS One 2019 7;14(2):e0211817. Epub 2019 Feb 7.

Department of Ophthalmology, University Medicine Greifswald, Greifswald, Mecklenburg-Western Pomerania, Germany.

Purpose: Exophthalmometry is a common examination in ophthalmology. For example it is relevant for diagnosis or follow-up of thyroid eye disease. However, exophthalmometry is affected by several factors such as ethnicity, sex and age. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211817PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366780PMC
February 2019
1 Read

Development of a risk scoring system for patients with papillary thyroid cancer.

J Cell Mol Med 2019 Feb 7. Epub 2019 Feb 7.

Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea.

As the importance of personalized therapeutics in aggressive papillary thyroid cancer (PTC) increases, accurate risk stratification is required. To develop a novel prognostic scoring system for patients with PTC (n = 455), we used mRNA expression and clinical data from The Cancer Genome Atlas. We performed variable selection using Network-Regularized high-dimensional Cox-regression with gene network from pathway databases. Read More

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http://dx.doi.org/10.1111/jcmm.14208DOI Listing
February 2019
1 Read

Follicular thyroid carcinoma metastatic to skin: a small papule and a big diagnostic change.

An Bras Dermatol 2019 Jan-Feb;94(1):76-78

Department of Pathology, Laboratório Bacchi, Botucatu (SP), Brazil.

Cutaneous metastases are uncommon in daily practice, although very important, since they may be the first manifestation of an undiscovered primary neoplasm or the first indication of recurrence. Cutaneous metastases from the breast are the most frequent in women and cutaneous metastases from the lung are the most frequent in men. Thyroid carcinoma, despite representing the most frequent endocrine neoplasm, is considered a rare neoplasm, corresponding to 1% of malignant neoplasms diagnosed. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20198299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360978PMC
February 2019
8 Reads

Conventional Thyroidectomy in the Treatment of Primary Thyroid Cancer.

Endocrinol Metab Clin North Am 2019 03;48(1):125-141

Department of Otolaryngology, Division of Thyroid and Parathyroid Endocrine Surgery, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA.

This article focuses on conventional surgical management of thyroid cancer, reviewing long-standing and well-accepted main principles and practices. It also covers newer controversies and techniques to conventional thyroidectomy, including changes in the indications for thyroidectomy, the intraoperative management of the recurrent and superior laryngeal nerves and parathyroid glands, the extent of thyroidectomy, and the importance of outcomes measurement and quality improvement. Read More

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http://dx.doi.org/10.1016/j.ecl.2018.11.003DOI Listing
March 2019
1 Read

Altered laryngeal morphology in Period1 deficient mice.

Ann Anat 2019 Feb 1;223:43-48. Epub 2019 Feb 1.

Dr. Senckenbergische Anatomie, Institute of Anatomy III, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany.

Background: Ultrasonic vocalizations (USV) of mice are produced in and emitted by the larynx. However, which anatomical elements of the mouse larynx are involved and to which aspects of USV they contribute is not clear. Frequency and amplitude parameters of mice, deficient in the clock gene Period1 (mPer1 mice) are distinguishably different compared to C3H wildtype (WT) controls. Read More

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http://dx.doi.org/10.1016/j.aanat.2019.01.009DOI Listing
February 2019
1 Read

County Median Family Income Is an Independent Prognostic Factor for Stage IV Anaplastic Thyroid Cancer.

Anticancer Res 2019 Feb;39(2):949-956

Division of Endocrinology, Department of Internal Medicine, St Vincent Hospital, Worcester, MA, U.S.A.

Background/aim: Advanced anaplastic thyroid cancer (ATC) is a rare, but highly aggressive malignancy, and its prognostic factors need to be further explored. We examined socioeconomic factors' predictive effect for survival performance in stage IV ATC patients.

Materials And Methods: Using the Surveillance, Epidemiology, and End Results database, we collected 1,048 cases with stage IV anaplastic thyroid cancer (ATC) from 2004 to 2015. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13198DOI Listing
February 2019
5 Reads

Expression of activator protein-1 in papillary thyroid carcinoma and its clinical significance.

World J Surg Oncol 2019 Jan 31;17(1):25. Epub 2019 Jan 31.

Department of Pancreatic & Endocrine Surgery, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, Liaoning Province, China.

Background: The abnormal expression of activator protein-1(AP-1) has recently been investigated in a variety of tumors. While the relationship between AP-1 and thyroid cancer is poorly studied, our study was to evaluate the protein expression and clinical value of AP-1 in papillary thyroid carcinoma (PTC).

Methods: The expression of AP-1 was examined by immunohistochemistry on paraffin-embedded tissues obtained from PTC and correspondent paracancerous tissues of 82 patients. Read More

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http://dx.doi.org/10.1186/s12957-019-1568-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357454PMC
January 2019
2 Reads

Falsely elevated thyroglobulin and calcitonin due to rheumatoid factor in non-relapsing thyroid carcinoma: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14178

Department of Translational Medical Sciences.

Rationale: Thyroglobulin (Tg) is an accurate indicator of clinical outcome after total thyroidectomy in patients with differentiated thyroid carcinoma. Usually, Tg levels agree with whole body scan. However, in some patient, discordant results were found, often because of Tg immunoassay interference. Read More

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http://dx.doi.org/10.1097/MD.0000000000014178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380811PMC
February 2019
1 Read

Cyclic adenosine monophoshate phosphodiesterase: a possible marker of thyroid pathology?

J Biol Regul Homeost Agents 2019 Jan-Feb,;33(1):281-285

Laboratory of Medical Chemistry and Dental Materials, Department of Medical, Oral and Biotechnological Sciences, University G. D'Annunzio, Chieti, Italy.

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January 2019

Retrospective Application of the 2015 American Thyroid Association Guidelines for Ultrasound Classification, Biopsy Indications, and Follow-up Imaging of Thyroid Nodules: Can Improved Reporting Decrease Testing?

Can Assoc Radiol J 2019 Feb;70(1):68-73

Division of Endocrinology, Department of Medicine, Sunnybrook Health Sciences Center, University of Toronto, Toronto, Ontario, Canada.

Introduction: Thyroid ultrasound has been widely used to determine which nodules need further investigation. The goal of this study is to determine if using an ultrasonographic features checklist based on 2015 American Thyroid Association (ATA) guidelines can improve reporting and decrease unnecessary further testing.

Methods: In this retrospective study, ultrasonographic images of all nodules biopsied at our institution in 2014 and 2015 were reviewed by radiologists blinded to fine needle aspiration (FNA) biopsy result using a checklist. Read More

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http://dx.doi.org/10.1016/j.carj.2018.09.001DOI Listing
February 2019
1 Read

Follow-up of Benign Thyroid Nodules-Can We Do Less?

Can Assoc Radiol J 2019 Feb;70(1):62-67

Division of Endocrinology, Department of Medicine, Sunnybrook Health Sciences Center, University of Toronto, Toronto, Ontario, Canada.

Objective: To determine the incidence of malignancy, follow-up ultrasound (US), and repeat fine needle aspiration (FNA) in thyroid nodules that have been previously biopsied as benign.

Methods: This is a retrospective, descriptive study of benign thyroid nodules evaluated by US between 2010-2011. We determined the frequency of follow-up ultrasounds and FNAs, mean years of follow-up, interval between follow-up US, change in nodule size, reasons for repeat FNA (rFNA), frequency of thyroidectomy, and thyroid malignancy during 5 years of follow-up. Read More

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http://dx.doi.org/10.1016/j.carj.2018.10.001DOI Listing
February 2019
3 Reads

Detection of BRAF V600E mutation in fine-needle aspiration fluid of papillary thyroid carcinoma by droplet digital PCR.

Clin Chim Acta 2019 Apr 22;491:91-96. Epub 2019 Jan 22.

Central Laboratory, Huashan Hospital, Fudan University, Shanghai, China; Dept. of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

Objectives: Papillary thyroid carcinoma (PTC) accounts for 85% of thyroid carcinoma, which is the most common endocrine tumor. For the diagnosis of PTC, ultrasound-guided fine needle aspiration (FNA) with pathological evaluation is the standard test and BRAF V600E mutation is the most common molecular marker associated with the occurrence, progression and poor clinicopathological characteristics of PTC. However, because of the small amount of the tumor cells obtained by FNA for pathological evaluation or BRAF V600E mutation detection, more sensitive and accurate methods are required. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00098981193003
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http://dx.doi.org/10.1016/j.cca.2019.01.017DOI Listing
April 2019
10 Reads

Clinical diagnostic value of contrast-enhanced ultrasound and TI-RADS classification for benign and malignant thyroid tumors: One comparative cohort study.

Medicine (Baltimore) 2019 Jan;98(4):e14051

Department of Ultrasound, Rizhao People's Hospital, Jining Medical University, Shandong Province, PRC.

To evaluate the diagnostic efficacy and clinical value of contrast-enhanced ultrasonography (CEUS) plus TI-RADS classification in benign and malignant thyroid tumors compared with either method alone.The informed consent was signed all patients. A total of 370 patients with thyroid tumors of TI-RADS category 3 and 4 were recruited, with 432 thyroid nodules. Read More

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http://dx.doi.org/10.1097/MD.0000000000014051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358332PMC
January 2019
5.723 Impact Factor

Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands.

Nat Commun 2019 01 21;10(1):368. Epub 2019 Jan 21.

Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Krankenhausstr. 8-10, 91054, Erlangen, Germany.

The molecular pathogenesis of salivary gland acinic cell carcinoma (AciCC) is poorly understood. The secretory Ca-binding phosphoprotein (SCPP) gene cluster at 4q13 encodes structurally related phosphoproteins of which some are specifically expressed at high levels in the salivary glands and constitute major components of saliva. Here we report on recurrent rearrangements [t(4;9)(q13;q31)] in AciCC that translocate active enhancer regions from the SCPP gene cluster to the region upstream of Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3) at 9q31. Read More

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http://dx.doi.org/10.1038/s41467-018-08069-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341107PMC
January 2019
3 Reads

RANK/RANKL signaling inhibition may improve the effectiveness of checkpoint blockade in cancer treatment.

Crit Rev Oncol Hematol 2019 Jan 3;133:85-91. Epub 2018 Nov 3.

Department of Histopathology, Antwerp University Hospital, Edegem, B2650, Belgium.

Binding between the receptor activator of nuclear factor-kB (RANK) and its ligand (RANKL) triggers recruitment of TNF receptor associated factor (TRAF) adaptor proteins and activation of downstream pathways. RANK/RANKL signaling is controlled by a decoy receptor called osteoprotegerin (OPG) which interacts with RANKL. Additional networks regulating RANK/RANKL signaling are active in a context specific manner. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10408428183036
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http://dx.doi.org/10.1016/j.critrevonc.2018.10.011DOI Listing
January 2019
11 Reads

Elastography detected solid organ stiffness increased in patients with acromegaly.

Medicine (Baltimore) 2019 Jan;98(3):e14212

Department of Internal Medicine.

Elastography is a method to examine the increase in solid organs stiffness (SOS), and there is no data in the literature regarding to its use in patients with acromegaly. In this study, we aimed to investigate the change of SOS in patients with acromegaly and to determine the parameters closely related to SOS in same patient groups.We included 40 subjects with acromegaly and 40 healthy control subjects. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901180-0009
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http://dx.doi.org/10.1097/MD.0000000000014212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370059PMC
January 2019
6 Reads

Simultaneous Hodgkin lymphoma and BRAFV600E-positive papillary thyroid carcinoma: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14180

Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, PR China.

Rationale: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. However, the simultaneous occurrence of PTC and Hodgkin Lymphoma (HL) was rarely reported.

Patient Concerns: We present a case of simultaneous BRAF-positive PTC and HL in a 17-year-old female. Read More

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http://dx.doi.org/10.1097/MD.0000000000014180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370130PMC
January 2019
2 Reads

Solitary colonic metastasis from primary lung adenocarcinoma first presenting as intestinal obstruction: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14063

Department of Surgery.

Rationale: The brain, liver, adrenal glands, and bone are the most common sites of metastatic disease in patients with lung cancer. Symptomatic gastrointestinal metastases are rare. In the present report, we describe a rare case of a patient with intestinal obstruction due to solitary colonic metastasis from primary lung adenocarcinoma, wherein the intestinal obstruction was the first symptom of lung cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000014063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370174PMC
January 2019
1 Read

An exonic splicing enhancer mutation in causes aberrant alternative splicing and severe congenital hypothyroidism in Bama pigs.

Dis Model Mech 2019 Jan 15;12(1). Epub 2019 Jan 15.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, China

Pigs share many similarities with humans in terms of anatomy, physiology and genetics, and have long been recognized as important experimental animals in biomedical research. Using an N-ethyl-N-nitrosourea (ENU) mutagenesis screen, we previously identified a large number of pig mutants, which could be further established as human disease models. However, the identification of causative mutations in large animals with great heterogeneity remains a challenging endeavor. Read More

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http://dmm.biologists.org/lookup/doi/10.1242/dmm.036616
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http://dx.doi.org/10.1242/dmm.036616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361156PMC
January 2019
9 Reads

Multidisciplinary treatment approach for primary thyroid spindle cell sarcoma: A case report.

Cancer Radiother 2019 Feb 12;23(1):46-49. Epub 2019 Jan 12.

Radiation Oncology, Centro di Riferimento di Aviano (CRO), IRCCS, via Gallini 2, 33081 Aviano (PN), Italy.

A 25-year-old female with high-grade spindle cell sarcoma of the thyroid persistent after thyroidectomy performed at another hospital was referred to our institute. Chemotherapy followed by surgery with intraoperative radiotherapy and postoperative intensity-modulated radiotherapy were planned within the sarcoma board. Chemotherapy was discontinued after two cycles because of local disease progression and surgery with intraoperative radiotherapy, was anticipated. Read More

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http://dx.doi.org/10.1016/j.canrad.2018.05.004DOI Listing
February 2019
1 Read

Comparison of thyroid hormone disruption potentials by bisphenols A, S, F, and Z in embryo-larval zebrafish.

Chemosphere 2019 Apr 4;221:115-123. Epub 2019 Jan 4.

School of Public Health, Seoul National University, Seoul, 08826, South Korea. Electronic address:

Several structural analogues of bisphenol A (BPA), e.g., bisphenol F (BPF), bisphenol S (BPS), and bisphenol Z (BPZ), have been used as its substitutes in many applications and consequently detected in the environment, and human specimen such as urine and serum. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.01.019DOI Listing

Bilateral thyrolinguofacial trunk: unusual and rare branching pattern of external carotid artery.

Anat Cell Biol 2018 Dec 29;51(4):302-304. Epub 2018 Dec 29.

Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India.

Prior knowledge of arterial supply to the head and neck is of substantial importance for well-planned surgeries involving the concerned region. We are reporting an unusual and rare variation in the branching pattern of external carotid artery in a 60-year-old female cadaver. A common trunk known as thyrolinguofacial trunk, originating from the anterior surface of the external carotid artery (right and left) giving of superior thyroid artery and a linguofacial trunk during a routine neck dissection. Read More

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http://dx.doi.org/10.5115/acb.2018.51.4.302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318451PMC
December 2018
1 Read

Anatomical variations and developmental anomalies of the thyroid gland in Ethiopian population: a cadaveric study.

Anat Cell Biol 2018 Dec 29;51(4):243-250. Epub 2018 Dec 29.

Department of Anatomy, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Because of its embryonic origin, the thyroid gland is predisposed to multiple anatomical variations and developmental anomalies. These include the pyramidal lobe, the origin of levator glandular thyroidae, the absence of the isthmus, ectopic thyroid, accessory thyroid tissues, etc. These anatomical variations are clinically significant to surgeons, anatomists, and researchers. Read More

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http://dx.doi.org/10.5115/acb.2018.51.4.243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318459PMC
December 2018