2,983 results match your criteria Thyroid Anaplastic Carcinoma


Incidental papillary thyroid microcarcinomas in thyroidectomy specimens: A single-center experience from Turkey.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):211-215

Department of Ear, Nose and Throat, Kayseri City Training and Research Hospital, Kayseri, Turkey.

Background: Papillary thyroid microcarcinoma (PTM) is a relatively common entity in the general population. PTM is often asymptomatic and is detected incidentally during the histopathological examination of thyroidectomy specimens from operations because of benign thyroid disease.

Aims: The aims of the study are to determine the incidence of incidental papillary thyroid microcarcinomas (IPTMs) in our center, to examine the clinicopathologic characteristics of these tumors, and to present our experiences. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_439_18DOI Listing
April 2019
1 Read

Induction of cell fusion/apoptosis in anaplastic thyroid carcinoma in orthotopic mouse model by urokinase-specific oncolytic Sendai virus.

Head Neck 2019 Apr 10. Epub 2019 Apr 10.

Department of Otolaryngology - Head and Neck Surgery, National Defense Medical College, Saitama, Japan.

Background: This study was designed to assess the therapeutic effect of urokinase-targeted recombinant oncolytic Sendai virus, termed "BioKnife," on anaplastic thyroid carcinoma (ATC).

Methods: Urokinase activity was investigated in human ATC cell lines, and BioKnife cytotoxicity against the cell lines was evaluated in vitro. Orthotopic mouse models of ATC were treated with three intratumoral injections of BioKnife, control virus, or phosphate-buffered saline (PBS) and were observed daily until >20% weight loss occurred. Read More

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http://dx.doi.org/10.1002/hed.25769DOI Listing
April 2019
2 Reads

An update on the central nervous system manifestations of DICER1 syndrome.

Acta Neuropathol 2019 Apr 5. Epub 2019 Apr 5.

Department of Pathology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Bader 104, Boston, MA, 02115, USA.

DICER1 syndrome is a rare tumor predisposition syndrome with manifestations that predominantly affect children and young adults. The syndrome is typically caused by heterozygous germline loss-of-function DICER1 alterations accompanied on the other allele by somatic missense mutations occurring at one of a few mutation hotspots within the sequence encoding the RNase IIIb domain. DICER1 encodes a member of the microRNA biogenesis machinery. Read More

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http://dx.doi.org/10.1007/s00401-019-01997-yDOI Listing
April 2019
2 Reads

Sodium orthovanadate inhibits growth and triggers apoptosis of human anaplastic thyroid carcinoma cells and .

Oncol Lett 2019 May 28;17(5):4255-4262. Epub 2019 Feb 28.

Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.

Vanadium and its compounds exhibit concentration- and time-dependent anticancer effects on various types of tumor; however, the effects of sodium orthovanadate (SOV) on anaplastic thyroid carcinoma (ATC) have not yet been reported. In the present study, the anticancer effects of SOV on ATC were evaluated. experiments, including cell viability assays, plate colony formation assays, cell cycle analysis and apoptosis analysis were used to study the role of SOV in ATC. Read More

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http://dx.doi.org/10.3892/ol.2019.10090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444324PMC
May 2019
2 Reads

Targeting CD47 in anaplastic thyroid carcinoma enhances tumor phagocytosis by macrophages and is a promising therapeutic strategy.

Thyroid 2019 Apr 2. Epub 2019 Apr 2.

University of Bern, Institute of Pathology, Bern, Bern, Switzerland ;

Background: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human cancers with a median survival of only 3-6 months. Standard treatment options and even targeted therapies have so far failed to improve long-term overall survival. Thus, novel treatment modalities for ATC, such as immunotherapy, are urgently needed. Read More

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http://dx.doi.org/10.1089/thy.2018.0555DOI Listing
April 2019
2 Reads

Clear Cell Variant of Papillary Thyroid Carcinoma With Associated Anaplastic Thyroid Carcinoma: Description of an Extraordinary Case.

Int J Surg Pathol 2019 Apr 1:1066896919837678. Epub 2019 Apr 1.

1 Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.

Clear cell change is a rare observation in thyroid cancer, resulting from aberrant cytoplasmic accumulation of lipids, glycogen, or thyroglobulin in the tumor cells. The phenomenon is most common for follicular thyroid neoplasia, with no definite coupling to patient outcome. The clear cell variant of papillary thyroid carcinoma (ccPTC) is even more infrequent-making conclusions regarding prognosis difficult. Read More

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http://dx.doi.org/10.1177/1066896919837678DOI Listing
April 2019
2 Reads

miR-650 promotes motility of anaplastic thyroid cancer cells by targeting PPP2CA.

Endocrine 2019 Mar 29. Epub 2019 Mar 29.

IRCCS SDN, Napoli, Via Emanuele Gianturco 113, 80143, Napoli, Italy.

Purpose: Aberrant expression of miRNAs is crucial in several tissues tumorigenesis including thyroid. Recent studies demonstrated that miR-650 plays different role depending on the cancer type. Herein, we investigated the role of miR-650 in thyroid carcinoma. Read More

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http://dx.doi.org/10.1007/s12020-019-01910-3DOI Listing
March 2019
2 Reads

Distribution and Activity of Lenvatinib in Brain Tumor Models of Human Anaplastic Thyroid Cancer Cells in Severe Combined Immune Deficient Mice.

Mol Cancer Ther 2019 Mar 29. Epub 2019 Mar 29.

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

Anaplastic thyroid carcinoma (ATC) is a rare but aggressive undifferentiated tumor that frequently metastasizes to the brain. The multiple kinase inhibitor lenvatinib and sorafenib have been approved to treat unresectable differentiated thyroid cancer, and lenvatinib has been approved in Japan to treat ATC. This study compared the effects of lenvatinib and sorafenib in mouse models of central nervous system metastases of ATC. Read More

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http://dx.doi.org/10.1158/1535-7163.MCT-18-0695DOI Listing
March 2019
5 Reads

Targeting super-enhancer-driven oncogenic transcription by CDK7 inhibition in anaplastic thyroid cancer.

Thyroid 2019 Mar 29. Epub 2019 Mar 29.

Tianjin Medical University, 12610, Tianjin, China ;

Background: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive malignancies with no effective treatment currently available. The molecular mechanisms of ATC carcinogenesis remain poorly understood. The objective of this study was to investigate the mechanisms and functions of super-enhancer-driven oncogenic transcriptional addiction in the progression of ATC and identify new drug targets for ATC treatments. Read More

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http://dx.doi.org/10.1089/thy.2018.0550DOI Listing
March 2019
3 Reads

Case Report: 84-Month Disease-Free Survival after Surgery for Anaplastic Thyroid Carcinoma.

J Nippon Med Sch 2019 ;86(1):38-42

Department of Breast and Thyroid Surgery, International University of Health and Welfare, Ichikawa Hospital.

We present a rare case of a patient with anaplastic thyroid carcinoma (ATC) who survived for 87 months after surgery. The patient was a 71-year-old man who presented with a painful enlarged mass in the right side of his neck that rapidly enlarged over 2 months. He was diagnosed with T4a, stage IVA ATC with no distant metastasis and underwent total thyroidectomy with modified neck dissection. Read More

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http://dx.doi.org/10.1272/jnms.JNMS.2019_86-7DOI Listing
January 2019
1 Read

Changing trends of incidence and prognosis of thyroid carcinoma.

Nuklearmedizin 2019 Mar 27;58(2):86-92. Epub 2019 Mar 27.

Clinic for Nuclear Medicine, University hospital Essen.

Aim: to evaluate the time trend of epidemiology of follicular cell derived thyroid cancer (TC) based on data from a well documented cancer registry.

Methods: Population based data on TC from Lower Franconia (LF), Germany, within 1981 and 2015 were analysed to estimate the regional epidemiology of TC. The incidence was assessed in 5-year-intervals for gender, histology, and tumor stage. Read More

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http://dx.doi.org/10.1055/a-0859-7454DOI Listing
March 2019
1 Read

Establishment of metastatic liver carcinoma model by implanting AX7 cells into rabbit liver, and its histological findings.

Int J Med Sci 2019 29;16(3):409-415. Epub 2019 Jan 29.

Division of Hepatobiliarypancreas and Transplantation, Department of Surgery, Pusan National University Hospital, Busan, Republic of Korea.

: Progression of metastatic liver carcinoma from any original cancer is aggressive and the prognosis is very poor. Therefore the new model that is easily approachable to study the propagation and prognosis of metastatic liver carcinoma is necessary. The aim of this study is to confirm the tumor formation and metastatic activity of anaplastic thyroid cancer and to support the research basis for the next generation cancer treatment that is to be developed, by carrying out additional experiments like cytokine stimulation. Read More

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http://www.medsci.org/v16p0409.htm
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http://dx.doi.org/10.7150/ijms.28998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428987PMC
January 2019
4 Reads

Promoter Hypomethylation as Recurrence Predictive Marker in Well-Differentiated Thyroid Carcinomas.

Int J Mol Sci 2019 Mar 16;20(6). Epub 2019 Mar 16.

Department of Clinical Genetics, Vejle Hospital, Institute of Regional Health Research, University of Southern Denmark, 7100 Vejle, Denmark.

Despite the low mortality rates, well-differentiated thyroid carcinomas (WDTC) frequently relapse. and mutations have been extensively related to prognosis in thyroid cancer. In this study, the methylation levels of selected CpGs (5-cytosine-phosphate-guanine-3) comprising a classifier, previously reported by our group, were assessed in combination with and mutations. Read More

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http://dx.doi.org/10.3390/ijms20061334DOI Listing
March 2019
1 Read

Immune Profiling of Thyroid Carcinomas Suggests the Existence of Two Major Phenotypes: an ATC-like and a PDTC-like.

J Clin Endocrinol Metab 2019 Mar 18. Epub 2019 Mar 18.

Department of Medicine, University of Perugia, Perugia.

Objectives: The understanding of the mechanisms underlying thyroid cancer immune escape can lead to the identification of new molecular targets and/or efficacy biomarkers. For this purpose, we performed immune expression profiling in thyroid cancers to obtain a comprehensive view on immune mechanisms activated during cancer progression.

Methods: The study was conducted retrospectively in 25 papillary thyroid carcinomas (PTC), 14 poorly differentiated thyroid carcinomas (PDTC), 13 anaplastic thyroid carcinomas (ATC) and 7 normal thyroid tissue samples (NT). Read More

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http://dx.doi.org/10.1210/jc.2018-01167DOI Listing
March 2019
2 Reads

Clinical Trials in Management of Anaplastic Thyroid Carcinoma; Progressions and Set Backs: A Systematic Review.

Int J Endocrinol Metab 2019 Jan 13;17(1):e67759. Epub 2019 Jan 13.

Department of Surgical Oncology, Division of Head and Neck Surgery, Duarte, United States.

Context: Anaplastic thyroid carcinoma (ATC) is associated with rapid tumor growth and extremely poor prognosis. Although ATC is found in only 2% of all thyroid carcinomas, it accounts for up to 50% of thyroid cancer mortality.

Objective: To understand the effect of different treatment modalities upon anaplastic thyroid cancer outcomes. Read More

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http://dx.doi.org/10.5812/ijem.67759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408732PMC
January 2019
1 Read

Clinicopathologic Features of Mismatch Repair-Deficient Anaplastic Thyroid Carcinomas.

Thyroid 2019 Apr 16. Epub 2019 Apr 16.

1 Department of Pathology; Harvard Medical School, Boston, Massachusetts.

Prior studies have reported mutations in mismatch repair (MMR) genes in a small subset of anaplastic thyroid carcinomas (ATC). The aim of this study was to identify MMR-protein-deficient (MMR-D) ATC and investigate their histopathologic features and clinical outcome. A cohort of 28 ATC diagnosed between 2003 and 2017 with tissue blocks available were evaluated. Read More

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http://dx.doi.org/10.1089/thy.2018.0716DOI Listing
April 2019
3 Reads
4.493 Impact Factor

Low lymphocyte-to-monocyte ratios are associated with poor overall survival in anaplastic thyroid carcinoma patients.

Thyroid 2019 Mar 13. Epub 2019 Mar 13.

Asan Medical Center, Internal medicine , 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, Korea , Seoul, Korea, Republic of , 138-736 ;

Background: The lymphocyte-to-monocyte ratio (LMR), which reflects the tumor infiltrating immune cell status and host immunity, has been reported as a prognostic marker in various cancers. The aim of the present study was to evaluate the role of LMR as a prognostic marker in predicting the survival of patients with anaplastic thyroid carcinoma (ATC).

Methods: We retrospectively included 35 ATC patients with available complete blood cell count (CBC) data. Read More

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http://dx.doi.org/10.1089/thy.2018.0684DOI Listing
March 2019
1 Read

Histone Deacetylase Inhibitors and Anaplastic Thyroid Carcinoma.

Anticancer Res 2019 Mar;39(3):1119-1127

Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Background/aim: Anaplastic thyroid cancer (ATC) is one of the most aggressive human malignancies, remaining generally incurable. Histone deacetylase (HDAC) seems to play a role in regulating transcription of genes involved in ATC, making HDAC inhibitors (HDACI) promising anticancer drugs for ATC. The purpose of this review was to evaluate the role of HDACIs in ATC treatment and describe the latest trends of current research on this field. Read More

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http://dx.doi.org/10.21873/anticanres.13220DOI Listing

Junctional adhesion molecule-A is down-regulated in anaplastic thyroid carcinomas and reduces cancer cell aggressiveness by modulating p53 and GSK3 α/β pathways.

Mol Carcinog 2019 Mar 4. Epub 2019 Mar 4.

IRCCS SDN, Napoli, Italy.

Junctional adhesion molecule A (JAM-A) is a transmembrane protein that contributes to different biological process, including the epithelial to mesenchymal transition (EMT). Through an EMT profiler array, we explored the molecular players associated with human thyroid cancer progression and identified JAM-A as one of the genes mostly deregulated. The quantitative real-time polymerase chain reaction and immunohistochemistry analyses showed that downregulation of JAM-A occurred in anaplastic thyroid carcinoma (ATC) compared with normal thyroid (NT) and papillary thyroid carcinoma (PTC) tissues and correlated with extrathyroid infiltration, tumor size, and ATC histotype. Read More

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http://dx.doi.org/10.1002/mc.23001DOI Listing
March 2019
4 Reads

Hypofractionated Radiotherapy for Anaplastic Thyroid Carcinoma: 15 Years of Experience in a Single Institution.

Eur Thyroid J 2019 Jan 4;8(1):24-30. Epub 2018 Oct 4.

Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background: Anaplastic thyroid carcinoma (ATC) is a rare cancer and has a poor prognosis. Several radiation protocols have been reported, but the results were not satisfactory.

Objective: The aim of this study was to determine the effect of hypofractionated radiotherapy. Read More

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http://dx.doi.org/10.1159/000493315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381908PMC
January 2019
1 Read

JAK/STAT3 and NF-κB Signaling Pathways Regulate Cancer Stem-Cell Properties in Anaplastic Thyroid Cancer Cells.

Thyroid 2019 Mar 15. Epub 2019 Mar 15.

1 Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.

Background: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and refractory cancers, and a therapy with a new concept needs to be developed. Recently, research on cancer stem cells (CSCs) has progressed, and CSCs have been suggested to be responsible for metastasis, recurrence, and therapy resistance. In ATC-CSCs, aldehyde dehydrogenase (ALDH) activity is the most reliable marker to enrich CSCs. Read More

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http://dx.doi.org/10.1089/thy.2018.0212DOI Listing
March 2019
2 Reads

Integrated Bioinformatics Analysis of Hub Genes and Pathways in Anaplastic Thyroid Carcinomas.

Int J Endocrinol 2019 13;2019:9651380. Epub 2019 Jan 13.

Department of General Surgery, Xuhui District Central Hospital of Shanghai, Shanghai 200031, China.

Anaplastic thyroid carcinoma (ATC) is a very rare malignancy; the pathogenesis of which is still not fully understood. The aim of the present study was to identify hub genes and pathways in ATC by microarray expression profiling. Two independent datasets (GSE27155 and GSE53072) were downloaded from GEO database. Read More

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http://dx.doi.org/10.1155/2019/9651380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350566PMC
January 2019
2 Reads

Clinico-Pathological Profile of Anaplastic Thyroid Carcinoma in an Endemic Goiter Area.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):793-797

Department of Endocrine Surgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh, India.

Introduction: Anaplastic thyroid cancers (ATCs) usually present in the sixth to seventh decades of life and little is known about the disease in young patients. The aim was to analyze the clinicopathological characteristics diagnosed with ATC in an iodine-deficient area.

Material And Methods: The medical records of 100 patients diagnosed with ATC at a tertiary care hospital between 1991 and 2013 were reviewed. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_264_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330874PMC
February 2019
1 Read

Presurgical Screening of Fine Needle Aspirates from Thyroid Nodules for Mutations: A Prospective Single Center Experience.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):785-792

Department of Endocrine Surgery, Christian Medical College, Ida Scudder Road, Vellore, Tamil Nadu, India.

Objective: Analysis of BRAF V600E mutation in thyroid fine needle aspirates (FNA) is an important adjunct to cytology, particularly among FNA placed in the "indeterminate category." However, such a prospective evaluation of FNA obtained from patients with thyroid nodules has been lacking from India.

Material And Methods: FNA from 277 patients were prospectively evaluated for BRAF mutations by Sanger's sequencing. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_126_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330867PMC
February 2019
1 Read

Blockade of the programmed death ligand 1 (PD-L1) as potential therapy for anaplastic thyroid cancer.

Endocrine 2019 Apr 14;64(1):122-129. Epub 2019 Feb 14.

University of Siena, Siena, Italy.

Purpose: Anaplastic thyroid carcinoma (ATC) is a rare, highly aggressive form of thyroid cancer (TC) characterized by an aggressive behavior and poor prognosis, resulting in patients' death within a year. Standard treatments, such as chemo and radiotherapy, as well as tyrosine kinase inhibitors, are ineffective for ATC treatment. Cancer immunotherapy is one of the most promising research area in oncology. Read More

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http://dx.doi.org/10.1007/s12020-019-01865-5DOI Listing
April 2019
1 Read
3.527 Impact Factor

Microsatellite Instability Occurs in a Subset of Follicular Thyroid Cancers.

Thyroid 2019 Apr 27;29(4):523-529. Epub 2019 Mar 27.

1 Department of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.

Background: Inactivation of DNA mismatch repair (MMR) and the resulting microsatellite instability (MSI) are frequently observed in endometrial, stomach, and colorectal cancers, as well as more rarely in other solid tumor types. The prevalence of MSI in thyroid cancer has not been explored in depth, although recent studies utilizing data from large cancer sequencing efforts such as The Cancer Genome Atlas indicate that MSI is absent or at least very rare in the most common and most well studied histologic subtype, papillary thyroid carcinoma. This study aimed to determine the prevalence of MSI in thyroid cancer by using a large series comprising all major histological subtypes. Read More

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http://dx.doi.org/10.1089/thy.2018.0655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457885PMC
April 2019
1 Read
4.493 Impact Factor

Poorly Differentiated Carcinoma of the Thyroid Gland: Current Status and Future Prospects.

Thyroid 2019 Mar;29(3):311-321

1 Department of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: Poorly differentiated thyroid cancer (PDTC) is a rare but clinically highly significant entity because it accounts for most fatalities from non-anaplastic follicular cell-derived thyroid cancer. Due to the relative rarity of the disease and heterogeneous diagnostic criteria, studies on PDTC have been limited. In light of the evolution of ultra-deep next-generation sequencing technologies and through correlation of clinicopathologic and genomic characteristics of PDTC, an improved understanding of the biology of PDTC has been facilitated. Read More

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http://dx.doi.org/10.1089/thy.2018.0509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437626PMC
March 2019
8 Reads

Angiosarcoma and anaplastic carcinoma of the thyroid are two distinct entities: a morphologic, immunohistochemical, and genetic study.

Mod Pathol 2019 Feb 5. Epub 2019 Feb 5.

Pathology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS, Reggio Emilia, Italy.

Angiosarcoma and anaplastic carcinoma are the most lethal neoplasms of the thyroid worldwide and share some similarities, which have led to a longstanding controversy on their etiopathological relationship. Thyroid angiosarcomas are characterized by vessel formation and an immunophenotype common to endothelial cells, while anaplastic carcinomas are partially or wholly composed of mesenchymal-like cells that have lost the morphologic and functional features of normal thyroid follicular cells. To investigate whether angiosarcomas represent the endothelial extreme of the differentiation spectrum of carcinomas or they are bona fide vascular neoplasms, we studied the clinico-morphologic and genetic characteristics of a series of 10 angiosarcomas and 22 anaplastic carcinomas. Read More

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http://www.nature.com/articles/s41379-018-0199-z
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http://dx.doi.org/10.1038/s41379-018-0199-zDOI Listing
February 2019
9 Reads

The Current Histologic Classification of Thyroid Cancer.

Authors:
Sylvia L Asa

Endocrinol Metab Clin North Am 2019 03;48(1):1-22

Department of Laboratory Medicine and Pathobiology, University of Toronto, Elizabeth Street, Toronto, Ontario M5G 2C4, Canada. Electronic address:

Thyroid cancers of follicular cell derivation provide excellent phenotype-genotype correlations. Current morphologic classifications are complex and require simplification. Benign adenomas have follicular or papillary architecture and bland cytology. Read More

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http://dx.doi.org/10.1016/j.ecl.2018.10.001DOI Listing
March 2019
4 Reads

County Median Family Income Is an Independent Prognostic Factor for Stage IV Anaplastic Thyroid Cancer.

Anticancer Res 2019 Feb;39(2):949-956

Division of Endocrinology, Department of Internal Medicine, St Vincent Hospital, Worcester, MA, U.S.A.

Background/aim: Advanced anaplastic thyroid cancer (ATC) is a rare, but highly aggressive malignancy, and its prognostic factors need to be further explored. We examined socioeconomic factors' predictive effect for survival performance in stage IV ATC patients.

Materials And Methods: Using the Surveillance, Epidemiology, and End Results database, we collected 1,048 cases with stage IV anaplastic thyroid cancer (ATC) from 2004 to 2015. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13198DOI Listing
February 2019
7 Reads

Metastasis to Stomach in a Patient with Anaplastic Thyroid Carcinoma: A Clinical Challenge.

Am J Case Rep 2019 Feb 1;20:134-138. Epub 2019 Feb 1.

Department of Surgical Oncology, HCG Manavata Cancer Centre, Nashik, Maharashtra, India.

BACKGROUND Anaplastic thyroid carcinoma (ATC) is an uncommon and aggressive form of human cancer. Despite advancement in multimodal therapy for patients with ATC, the prognosis remains poor. Most patients presenting with ATC have metastasis to the lungs and regional lymph nodes. Read More

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https://www.amjcaserep.com/abstract/index/idArt/913736
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http://dx.doi.org/10.12659/AJCR.913736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368130PMC
February 2019
8 Reads

PI3K/mTOR inhibition potentiates and extends palbociclib activity in anaplastic thyroid cancer.

Endocr Relat Cancer 2019 Jan 1. Epub 2019 Jan 1.

A Di Cristofano, Developmental and Molecular Biology, Albert Einstein College of Medicine, BRONX, United States.

Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer. Despite its low incidence, it accounts for a disproportionate number of thyroid cancer-related deaths, because of its resistance to current therapeutic approaches. Novel actionable targets are urgently needed to prolong patient survival and increase their quality of life. Read More

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https://erc.bioscientifica.com/view/journals/erc/aop/erc-19-
Publisher Site
http://dx.doi.org/10.1530/ERC-19-0011DOI Listing
January 2019
28 Reads

CK7 negative anaplastic thyroid carcinoma presenting as cutaneous metastases to the scalp.

Dermatol Online J 2018 11 15;24(11). Epub 2018 Nov 15.

Division of Dermatology, University of Louisville, Louisville, Kentucky.

Anaplastic thyroid carcinoma (ATC) is an extremely rare but aggressive form of thyroid cancer. Although local tissue invasion is characteristic of this disease, systemic metastases are a common clinical finding. Our case discusses an unusual presentation of cutaneous metastases to the scalp in a patient with a remote history of ATC. Read More

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November 2018
1 Read

Anaplastic lymphoma kinase fusions: Roles in cancer and therapeutic perspectives.

Oncol Lett 2019 Feb 20;17(2):2020-2030. Epub 2018 Dec 20.

Zhejiang Provincial Key Laboratory of Silkworm Bioreactors and Biomedicine, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, P.R. China.

Receptor tyrosine kinase (RTK) anaplastic lymphoma kinase (ALK) serves a crucial role in brain development. is located on the short arm of chromosome 2 (2p23) and exchange of chromosomal segments with other genes, including nucleophosmin (), echinoderm microtubule-associated protein-like 4 () and -fused gene (), readily occurs. Such chromosomal translocation results in the formation of chimeric fusion oncoproteins, which possess potential oncogenic functions due to constitutive activation of ALK kinase. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9856
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http://dx.doi.org/10.3892/ol.2018.9856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341817PMC
February 2019
15 Reads

HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid Cancer.

Int J Mol Sci 2019 Jan 21;20(2). Epub 2019 Jan 21.

Department of Medical Laboratory, Taipei Medical University-Shuang Ho Hospital, New Taipei City 23561, Taiwan.

Anaplastic thyroid carcinoma (ATC) and squamous thyroid carcinoma (STC) are both rare and advanced thyroid malignancies with a very poor prognosis and an average median survival time of 5 months and less than 20% of affected patients are alive 1 year after diagnosis. The clinical management of both ATC and STC is very similar because they are not particularly responsive to radiotherapy and chemotherapy. This inspired us to explore a novel and effective clinically approved therapy for ATC treatment. Read More

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http://dx.doi.org/10.3390/ijms20020454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359659PMC
January 2019
3 Reads

Targetable gene fusions identified in radioactive iodine refractory advanced thyroid carcinoma.

Eur J Endocrinol 2019 Apr;180(4):235-241

Department of Pathology, Division of Endocrinology, Leiden University Medical Centre, Leiden, the Netherlands.

Objective Gene alterations leading to activation of the MAPK pathway are of interest for targeted therapy in patients with advanced radioactive iodine refractory (RAI-R) thyroid carcinoma. Due to technical reasons gene fusion analysis in RNA isolated from formalin-fixed tumor tissues has till now been limited. The objective of the present study was to identify targetable gene rearrangements in RNA isolated from formalin-fixed RAI-R thyroid carcinomas. Read More

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https://eje.bioscientifica.com/view/journals/eje/aop/eje-18-
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http://dx.doi.org/10.1530/EJE-18-0653DOI Listing
April 2019
11 Reads

Anaplastic Carcinoma Thyroid in a Young Child - an Extremely Rare Occurrence.

Acta Medica (Hradec Kralove) 2018;61(4):150-152

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Anaplastic thyroid carcinoma (ATC), one of the most aggressive malignancies, is extremely rare in childhood. We present a case of 5-yearold child who presented with rapidly progressing thyroid swelling and stridor, for which she underwent emergency tracheostomy and biopsy. Histopathological features were suggestive of ATC and the patient died within two months after diagnosis. Read More

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http://dx.doi.org/10.14712/18059694.2018.134DOI Listing
January 2018
4 Reads

Minimally invasive thyroid anaplastic carcinoma with long survival.

Turk J Surg 2018 Dec 1;34(4):319-322. Epub 2018 Dec 1.

Department of General Surgery, Marmara University School of Medicine, İstanbul, Turkey.

Anaplastic thyroid carcinoma is a highly lethal malignancy. Previously, only five cases of a noninvasive form of anaplastic thyroid carcinoma with excellent prognosis were reported. We report a case of a 68-year-old man who presented with a 3. Read More

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http://dx.doi.org/10.5152/turkjsurg.2017.3383DOI Listing
December 2018
5 Reads

Anaplastic Thyroid Carcinoma with Gastric Metastasis.

Curr Health Sci J 2018 Jul-Sep;44(3):294-298. Epub 2018 Jul 15.

Department of Gastroenterology, Hepatology, and Nutrition, University of Texas-MD Anderson Cancer Center, Houston, Texas, USA.

Introduction: Carcinomas of the thyroid gland represent 3% of all malignancies, with 1.3 to 9.8% corresponding to anaplastic thyroid carcinomas (ATC). Read More

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http://dx.doi.org/10.12865/CHSJ.44.03.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311218PMC
July 2018
10 Reads

A Phase II study of the safety and efficacy of lenvatinib in patients with advanced thyroid cancer.

Future Oncol 2019 Mar 14;15(7):717-726. Epub 2019 Jan 14.

Department of Head & Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

Aim: To investigate the safety and efficacy of lenvatinib in advanced thyroid cancer.

Patients/methods: In this Phase II study, 51 Japanese patients with radioiodine-refractory differentiated thyroid cancer (RR-DTC), medullary thyroid cancer (MTC) or anaplastic thyroid cancer (ATC) received once-daily lenvatinib 24 mg. The primary end point was safety. Read More

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http://dx.doi.org/10.2217/fon-2018-0557DOI Listing
March 2019
6 Reads

Antitumor Effect of Various Phytochemicals on Diverse Types of Thyroid Cancers.

Nutrients 2019 Jan 9;11(1). Epub 2019 Jan 9.

Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Korea.

Thyroid cancers developed from the tissues of the thyroid gland are classified into papillary (PTC), follicular (FTC), medullary (MTC), and anaplastic thyroid cancer (ATC). Although thyroid cancers have been generally known as mild forms of cancer, undifferentiated MTC and ATC have a more unfavorable prognosis than differentiated PTC and FTC because they are more aggressive and early metastatic. A variety of therapies such as surgery, radiotherapy, and chemotherapy have been currently used to treat thyroid cancer, but they still have limitations including drug resistance or unfavorable side effects. Read More

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http://www.mdpi.com/2072-6643/11/1/125
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http://dx.doi.org/10.3390/nu11010125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356543PMC
January 2019
14 Reads

Antineoplastic Effect of Lenvatinib and Vandetanib in Primary Anaplastic Thyroid Cancer Cells Obtained From Biopsy or Fine Needle Aspiration.

Front Endocrinol (Lausanne) 2018 18;9:764. Epub 2018 Dec 18.

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Anaplastic thyroid carcinoma (ATC) is a malignant tumor of the thyroid gland, infrequent but with a very poor prognosis, as it rapidly causes death (mean survival of about 6 months). ATC treatment includes a multimodal protocol consisting of surgery, chemotherapy (doxorubicin and cisplatin), and hyperfractionated accelerated external beam radiotherapy (median patient survival of 10 months). For this reason, the identification of an effective systemic treatment for ATC would be a major advance in the management of this deadly thyroid cancer. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2018.00764
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http://dx.doi.org/10.3389/fendo.2018.00764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305332PMC
December 2018
4 Reads

Liquid Biopsy in Thyroid Cancer: New Insight.

Int J Hematol Oncol Stem Cell Res 2018 Jul;12(3):235-248

Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Thyroid cancer, one of the most widespread malignancies of the endocrine-related system that over the past three decades, has a vivid increasing rate. The diagnosis and management of it is dependent on the tumor type and stage. Thyroid cancer is divided into four main types, including PTC (papillary thyroid carcinoma), FTC (follicular thyroid carcinoma), MTC (medullarly thyroid carcinoma), and ATC (anaplastic thyroid carcinoma). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305265PMC
July 2018
4 Reads

New and emerging renal entities: a perspective post-WHO 2016 classification.

Histopathology 2019 Jan;74(1):31-59

Charles University and University Hospital Pilsen, Pilsen, Czech Republic.

Renal tumours include a heterogeneous and diverse spectrum of neoplasms. Recent advances in this field have significantly improved our understanding of the morphological, immunohistochemical, molecular, epidemiological and clinical characteristics of renal tumours, which led to the new Vancouver classification of renal neoplasia and the new World Health Organization (WHO) classification of renal cell tumours. This review aims to summarise the new information and evidence on several new and emerging/provisional renal entities, which were mostly generated after the recent classification of renal neoplasia. Read More

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http://dx.doi.org/10.1111/his.13727DOI Listing
January 2019
6 Reads
3.453 Impact Factor

Secretory Carcinoma of the Thyroid Gland: Report of a Highly Aggressive Case Clinically Mimicking Undifferentiated Carcinoma and Review of the Literature.

Head Neck Pathol 2018 Dec 18. Epub 2018 Dec 18.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, 3020D Vanderbilt University Hospital, 1211 Medical Center Drive, Nashville, TN, 37232-7415, USA.

After being described in the salivary glands as a malignancy with features essentially identical to those of the breast, secretory carcinoma (SC) (formerly mammary analogue SC) has now been identified in other sites including the skin, lung, and thyroid gland. In the breast, SC has a relatively favorable prognosis. Likewise when arising in the salivary glands, it is generally considered to be a low to intermediate grade carcinoma; however, there is a range of clinical behavior with occasional patients dying of progressive disease. Read More

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http://dx.doi.org/10.1007/s12105-018-0995-2DOI Listing
December 2018
12 Reads

Targeted next-generation sequencing of cancer-related genes in thyroid carcinoma: A single institution's experience.

Oncol Lett 2018 Dec 2;16(6):7278-7286. Epub 2018 Oct 2.

Department of Biology and Genetics, Laboratory of Cancer Medical Science, Hokuto Hospital, Obihiro, Hokkaido 080-0833, Japan.

Thyroid carcinoma (TC) has characteristic genetic alterations, including point mutations in proto-oncogenes and chromosomal rearrangements that vary by histologic subtype. Recent developments in next-generation sequencing (NGS) technology enable simultaneous analysis of cancer-associated genes of interest, thus improving diagnostic accuracy and allowing precise personalized treatment for human cancer. A total of 50 patients who underwent thyroidectomy between 2014 and 2016 at Hokuto Hospital were enrolled. Read More

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http://dx.doi.org/10.3892/ol.2018.9538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256352PMC
December 2018
2 Reads

NCCN Guidelines Insights: Thyroid Carcinoma, Version 2.2018.

J Natl Compr Canc Netw 2018 Dec;16(12):1429-1440

Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center-James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

The NCCN Guidelines for Thyroid Carcinoma provide recommendations for the management of different types of thyroid carcinoma, including papillary, follicular, Hürthle cell, medullary, and anaplastic carcinomas. These NCCN Guidelines Insights summarize the panel discussion behind recent updates to the guidelines, including the expanding role of molecular testing for differentiated thyroid carcinoma, implications of the new pathologic diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features, and the addition of a new targeted therapy option for V600E-mutated anaplastic thyroid carcinoma. Read More

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http://www.jnccn.org/lookup/doi/10.6004/jnccn.2018.0089
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http://dx.doi.org/10.6004/jnccn.2018.0089DOI Listing
December 2018
20 Reads
4.178 Impact Factor

Liposomal Delivery of miR-34b-5p Induced Cancer Cell Death in Thyroid Carcinoma.

Cells 2018 Dec 11;7(12). Epub 2018 Dec 11.

Cancer Molecular Pathology, School of Medicine, Griffith University, Gold Coast, Queensland 4222, Australia.

This study aims to determine the functional roles of microRNA-34b-5p (miR-34b) in the suppression of anaplastic thyroid carcinoma. We used hydration-of-freeze-dried-matrix (HFDM) formulated liposomes (liposome-loaded miR-34b) for effective delivery of miR-34b to anaplastic thyroid carcinoma in vitro and in vivo. Real time polymerase chain was used to determine the level of miR-34b. Read More

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http://www.mdpi.com/2073-4409/7/12/265
Publisher Site
http://dx.doi.org/10.3390/cells7120265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315437PMC
December 2018
5 Reads