2,952 results match your criteria Thyroid Anaplastic Carcinoma


The JAK/STAT3 and NF-κB signaling pathways regulate cancer stem cell properties in anaplastic thyroid cancer cells.

Thyroid 2019 Feb 20. Epub 2019 Feb 20.

Nagasaki University, Radiation Medical Sciences, Atomic Bomb Disease Institute , 1-12-4 Sakamoto , Nagasaki, Japan , 852-8523 ;

Background: Anaplastic thyroid carcinoma (ATC) is still one of the most aggressive cancers, and a therapy with a new concept needs to be developed. Recently, the research of cancer stem cells (CSCs) has been progressed, and CSCs have been suggested to be responsible for metastasis, recurrence, and therapy resistance. In ATC-CSCs, aldehyde dehydrogenase (ALDH) activity is the most reliable marker to enrich the CSCs; however, it itself is just a marker and is not involved in CSC properties. Read More

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http://dx.doi.org/10.1089/thy.2018.0212DOI Listing
February 2019

Why is there such a poor prognosis associated with anaplastic thyroid carcinoma?

Authors:
Richard O Wein

Expert Rev Endocrinol Metab 2012 Sep;7(5):483-485

a Department of Otolaryngology - Head and Neck Surgery,Tufts Medical Center, 800 Washington Street, Box 850, Boston, MA 02111, USA.

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http://dx.doi.org/10.1586/eem.12.46DOI Listing
September 2012

Managing anaplastic thyroid carcinoma.

Expert Rev Endocrinol Metab 2011 Nov;6(6):793-809

a Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, USA.

Anaplastic thyroid cancer is one of the most lethal malignancies, with dismal prognosis, resistance to multimodal treatments and a median survival of only 5-6 months. Advances in the discovery of genetic pathway aberrations involved in this aggressive disease have been made, and multiple novel therapies targeting these pathways are undergoing clinical trials. So far, there is no single effective treatment for this disease; however, multimodal therapies with a combination of surgery, radiation and chemotherapy hold some promise. Read More

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http://dx.doi.org/10.1586/eem.11.76DOI Listing
November 2011

Integrated Bioinformatics Analysis of Hub Genes and Pathways in Anaplastic Thyroid Carcinomas.

Int J Endocrinol 2019 13;2019:9651380. Epub 2019 Jan 13.

Department of General Surgery, Xuhui District Central Hospital of Shanghai, Shanghai 200031, China.

Anaplastic thyroid carcinoma (ATC) is a very rare malignancy; the pathogenesis of which is still not fully understood. The aim of the present study was to identify hub genes and pathways in ATC by microarray expression profiling. Two independent datasets (GSE27155 and GSE53072) were downloaded from GEO database. Read More

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http://dx.doi.org/10.1155/2019/9651380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350566PMC
January 2019

Clinico-Pathological Profile of Anaplastic Thyroid Carcinoma in an Endemic Goiter Area.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):793-797

Department of Endocrine Surgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh, India.

Introduction: Anaplastic thyroid cancers (ATCs) usually present in the sixth to seventh decades of life and little is known about the disease in young patients. The aim was to analyze the clinicopathological characteristics diagnosed with ATC in an iodine-deficient area.

Material And Methods: The medical records of 100 patients diagnosed with ATC at a tertiary care hospital between 1991 and 2013 were reviewed. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_264_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330874PMC
February 2019
1 Read

Presurgical Screening of Fine Needle Aspirates from Thyroid Nodules for Mutations: A Prospective Single Center Experience.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):785-792

Department of Endocrine Surgery, Christian Medical College, Ida Scudder Road, Vellore, Tamil Nadu, India.

Objective: Analysis of BRAF V600E mutation in thyroid fine needle aspirates (FNA) is an important adjunct to cytology, particularly among FNA placed in the "indeterminate category." However, such a prospective evaluation of FNA obtained from patients with thyroid nodules has been lacking from India.

Material And Methods: FNA from 277 patients were prospectively evaluated for BRAF mutations by Sanger's sequencing. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_126_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330867PMC
February 2019
1 Read

Blockade of the programmed death ligand 1 (PD-L1) as potential therapy for anaplastic thyroid cancer.

Endocrine 2019 Feb 14. Epub 2019 Feb 14.

University of Siena, Siena, Italy.

Purpose: Anaplastic thyroid carcinoma (ATC) is a rare, highly aggressive form of thyroid cancer (TC) characterized by an aggressive behavior and poor prognosis, resulting in patients' death within a year. Standard treatments, such as chemo and radiotherapy, as well as tyrosine kinase inhibitors, are ineffective for ATC treatment. Cancer immunotherapy is one of the most promising research area in oncology. Read More

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http://dx.doi.org/10.1007/s12020-019-01865-5DOI Listing
February 2019
3.527 Impact Factor

Microsatellite Instability Occurs in a Subset of Follicular Thyroid Cancers.

Thyroid 2019 Feb 12. Epub 2019 Feb 12.

The Ohio State University, Department of Cancer Biology and Genetics, Columbus, Ohio, United States ;

Background: Inactivation of DNA mismatch repair (MMR) and the resulting microsatellite instability (MSI) are frequently observed in endometrial, stomach and colorectal cancers as well as more rarely in other solid tumor types. The prevalence of MSI in thyroid cancer has not been explored in-depth, although recent studies utilizing data from large cancer sequencing efforts such as The Cancer Genome Atlas indicate MSI is absent or at least very rare in the most common and most well-studied histologic subtype, papillary carcinoma. In this study, we aim to determine the prevalence of MSI in thyroid cancer by using a large series comprising all major histological subtypes. Read More

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http://dx.doi.org/10.1089/thy.2018.0655DOI Listing
February 2019
1 Read
4.493 Impact Factor

Poorly differentiated carcinoma of the thyroid gland: Current status and future prospects.

Thyroid 2019 Feb 12. Epub 2019 Feb 12.

Memorial Sloan Kettering Cancer Center, Department of Surgery, Head and Neck Service , New York, New York, United States ;

Background: Poorly differentiated thyroid cancer (PDTC) is a rare but clinically highly significant entity because it accounts for most fatalities from non-anaplastic follicular cell-derived thyroid cancer. Due to the relative rarity of the disease and heterogeneous diagnostic criteria, studies on PDTC have been limited. In light of the evolution of ultra deep next-generation sequencing (NGS) technologies and through correlation of clinico-pathological and genomic characteristics of PDTC, an improved understanding of the biology of PDTC has been facilitated. Read More

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http://dx.doi.org/10.1089/thy.2018.0509DOI Listing
February 2019
1 Read

Angiosarcoma and anaplastic carcinoma of the thyroid are two distinct entities: a morphologic, immunohistochemical, and genetic study.

Mod Pathol 2019 Feb 5. Epub 2019 Feb 5.

Pathology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS, Reggio Emilia, Italy.

Angiosarcoma and anaplastic carcinoma are the most lethal neoplasms of the thyroid worldwide and share some similarities, which have led to a longstanding controversy on their etiopathological relationship. Thyroid angiosarcomas are characterized by vessel formation and an immunophenotype common to endothelial cells, while anaplastic carcinomas are partially or wholly composed of mesenchymal-like cells that have lost the morphologic and functional features of normal thyroid follicular cells. To investigate whether angiosarcomas represent the endothelial extreme of the differentiation spectrum of carcinomas or they are bona fide vascular neoplasms, we studied the clinico-morphologic and genetic characteristics of a series of 10 angiosarcomas and 22 anaplastic carcinomas. Read More

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http://www.nature.com/articles/s41379-018-0199-z
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http://dx.doi.org/10.1038/s41379-018-0199-zDOI Listing
February 2019
3 Reads

The Current Histologic Classification of Thyroid Cancer.

Authors:
Sylvia L Asa

Endocrinol Metab Clin North Am 2019 03;48(1):1-22

Department of Laboratory Medicine and Pathobiology, University of Toronto, Elizabeth Street, Toronto, Ontario M5G 2C4, Canada. Electronic address:

Thyroid cancers of follicular cell derivation provide excellent phenotype-genotype correlations. Current morphologic classifications are complex and require simplification. Benign adenomas have follicular or papillary architecture and bland cytology. Read More

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http://dx.doi.org/10.1016/j.ecl.2018.10.001DOI Listing
March 2019
1 Read

Metastasis to Stomach in a Patient with Anaplastic Thyroid Carcinoma: A Clinical Challenge.

Am J Case Rep 2019 Feb 1;20:134-138. Epub 2019 Feb 1.

Department of Surgical Oncology, HCG Manavata Cancer Centre, Nashik, Maharashtra, India.

BACKGROUND Anaplastic thyroid carcinoma (ATC) is an uncommon and aggressive form of human cancer. Despite advancement in multimodal therapy for patients with ATC, the prognosis remains poor. Most patients presenting with ATC have metastasis to the lungs and regional lymph nodes. Read More

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https://www.amjcaserep.com/abstract/index/idArt/913736
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http://dx.doi.org/10.12659/AJCR.913736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368130PMC
February 2019
4 Reads

PI3K/mTOR inhibition potentiates and extends palbociclib activity in anaplastic thyroid cancer.

Endocr Relat Cancer 2019 Jan 1. Epub 2019 Jan 1.

A Di Cristofano, Developmental and Molecular Biology, Albert Einstein College of Medicine, BRONX, United States.

Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer. Despite its low incidence, it accounts for a disproportionate number of thyroid cancer-related deaths, because of its resistance to current therapeutic approaches. Novel actionable targets are urgently needed to prolong patient survival and increase their quality of life. Read More

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https://erc.bioscientifica.com/view/journals/erc/aop/erc-19-
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http://dx.doi.org/10.1530/ERC-19-0011DOI Listing
January 2019
9 Reads

CK7 negative anaplastic thyroid carcinoma presenting as cutaneous metastases to the scalp.

Dermatol Online J 2018 11 15;24(11). Epub 2018 Nov 15.

Division of Dermatology, University of Louisville, Louisville, Kentucky.

Anaplastic thyroid carcinoma (ATC) is an extremely rare but aggressive form of thyroid cancer. Although local tissue invasion is characteristic of this disease, systemic metastases are a common clinical finding. Our case discusses an unusual presentation of cutaneous metastases to the scalp in a patient with a remote history of ATC. Read More

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November 2018

Anaplastic lymphoma kinase fusions: Roles in cancer and therapeutic perspectives.

Oncol Lett 2019 Feb 20;17(2):2020-2030. Epub 2018 Dec 20.

Zhejiang Provincial Key Laboratory of Silkworm Bioreactors and Biomedicine, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, P.R. China.

Receptor tyrosine kinase (RTK) anaplastic lymphoma kinase (ALK) serves a crucial role in brain development. is located on the short arm of chromosome 2 (2p23) and exchange of chromosomal segments with other genes, including nucleophosmin (), echinoderm microtubule-associated protein-like 4 () and -fused gene (), readily occurs. Such chromosomal translocation results in the formation of chimeric fusion oncoproteins, which possess potential oncogenic functions due to constitutive activation of ALK kinase. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9856
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http://dx.doi.org/10.3892/ol.2018.9856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341817PMC
February 2019
8 Reads

HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid Cancer.

Int J Mol Sci 2019 Jan 21;20(2). Epub 2019 Jan 21.

Department of Medical Laboratory, Taipei Medical University-Shuang Ho Hospital, New Taipei City 23561, Taiwan.

Anaplastic thyroid carcinoma (ATC) and squamous thyroid carcinoma (STC) are both rare and advanced thyroid malignancies with a very poor prognosis and an average median survival time of 5 months and less than 20% of affected patients are alive 1 year after diagnosis. The clinical management of both ATC and STC is very similar because they are not particularly responsive to radiotherapy and chemotherapy. This inspired us to explore a novel and effective clinically approved therapy for ATC treatment. Read More

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http://dx.doi.org/10.3390/ijms20020454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359659PMC
January 2019
1 Read

Targetable Gene Fusions Identified in Radioactive Iodine-Refractory Advanced Thyroid Carcinoma.

Eur J Endocrinol 2019 Jan 1. Epub 2019 Jan 1.

H Morreau, Pathology, Leiden University Medical Center, Leiden, Netherlands.

Objective: Gene alterations leading to activation of the MAPK pathway are of interest for targeted therapy in patients with advanced radioactive iodine-refractory (RAI-R) thyroid carcinoma. Due to technical reasons gene fusion analysis in RNA isolated from formalin-fixed tumor tissues has till now been limited. The objective of the present study was to identify targetable gene rearrangements in RNA isolated from formalin-fixed RAI-R thyroid carcinomas. Read More

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https://eje.bioscientifica.com/view/journals/eje/aop/eje-18-
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http://dx.doi.org/10.1530/EJE-18-0653DOI Listing
January 2019
5 Reads

Anaplastic Carcinoma Thyroid in a Young Child - an Extremely Rare Occurrence.

Acta Medica (Hradec Kralove) 2018 ;61(4):150-152

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Anaplastic thyroid carcinoma (ATC), one of the most aggressive malignancies, is extremely rare in childhood. We present a case of 5-yearold child who presented with rapidly progressing thyroid swelling and stridor, for which she underwent emergency tracheostomy and biopsy. Histopathological features were suggestive of ATC and the patient died within two months after diagnosis. Read More

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http://dx.doi.org/10.14712/18059694.2018.134DOI Listing
January 2018
2 Reads

Minimally invasive thyroid anaplastic carcinoma with long survival.

Turk J Surg 2018 Dec 1;34(4):319-322. Epub 2018 Dec 1.

Department of General Surgery, Marmara University School of Medicine, İstanbul, Turkey.

Anaplastic thyroid carcinoma is a highly lethal malignancy. Previously, only five cases of a noninvasive form of anaplastic thyroid carcinoma with excellent prognosis were reported. We report a case of a 68-year-old man who presented with a 3. Read More

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http://dx.doi.org/10.5152/turkjsurg.2017.3383DOI Listing
December 2018
1 Read

Anaplastic Thyroid Carcinoma with Gastric Metastasis.

Curr Health Sci J 2018 Jul-Sep;44(3):294-298. Epub 2018 Jul 15.

Department of Gastroenterology, Hepatology, and Nutrition, University of Texas-MD Anderson Cancer Center, Houston, Texas, USA.

Introduction: Carcinomas of the thyroid gland represent 3% of all malignancies, with 1.3 to 9.8% corresponding to anaplastic thyroid carcinomas (ATC). Read More

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http://dx.doi.org/10.12865/CHSJ.44.03.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311218PMC
July 2018
3 Reads

A Phase II study of the safety and efficacy of lenvatinib in patients with advanced thyroid cancer.

Future Oncol 2019 Jan 14. Epub 2019 Jan 14.

Department of Head & Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

Aim: To investigate the safety and efficacy of lenvatinib in advanced thyroid cancer.

Patients/methods: In this Phase II study, 51 Japanese patients with radioiodine-refractory differentiated thyroid cancer (RR-DTC), medullary thyroid cancer (MTC) or anaplastic thyroid cancer (ATC) received once-daily lenvatinib 24 mg. The primary end point was safety. Read More

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http://dx.doi.org/10.2217/fon-2018-0557DOI Listing
January 2019
2 Reads

Antineoplastic Effect of Lenvatinib and Vandetanib in Primary Anaplastic Thyroid Cancer Cells Obtained From Biopsy or Fine Needle Aspiration.

Front Endocrinol (Lausanne) 2018 18;9:764. Epub 2018 Dec 18.

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Anaplastic thyroid carcinoma (ATC) is a malignant tumor of the thyroid gland, infrequent but with a very poor prognosis, as it rapidly causes death (mean survival of about 6 months). ATC treatment includes a multimodal protocol consisting of surgery, chemotherapy (doxorubicin and cisplatin), and hyperfractionated accelerated external beam radiotherapy (median patient survival of 10 months). For this reason, the identification of an effective systemic treatment for ATC would be a major advance in the management of this deadly thyroid cancer. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2018.00764
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http://dx.doi.org/10.3389/fendo.2018.00764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305332PMC
December 2018
2 Reads

Liquid Biopsy in Thyroid Cancer: New Insight.

Int J Hematol Oncol Stem Cell Res 2018 Jul;12(3):235-248

Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Thyroid cancer, one of the most widespread malignancies of the endocrine-related system that over the past three decades, has a vivid increasing rate. The diagnosis and management of it is dependent on the tumor type and stage. Thyroid cancer is divided into four main types, including PTC (papillary thyroid carcinoma), FTC (follicular thyroid carcinoma), MTC (medullarly thyroid carcinoma), and ATC (anaplastic thyroid carcinoma). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305265PMC
July 2018
3 Reads

New and emerging renal entities: a perspective post-WHO 2016 classification.

Histopathology 2019 Jan;74(1):31-59

Charles University and University Hospital Pilsen, Pilsen, Czech Republic.

Renal tumours include a heterogeneous and diverse spectrum of neoplasms. Recent advances in this field have significantly improved our understanding of the morphological, immunohistochemical, molecular, epidemiological and clinical characteristics of renal tumours, which led to the new Vancouver classification of renal neoplasia and the new World Health Organization (WHO) classification of renal cell tumours. This review aims to summarise the new information and evidence on several new and emerging/provisional renal entities, which were mostly generated after the recent classification of renal neoplasia. Read More

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http://dx.doi.org/10.1111/his.13727DOI Listing
January 2019
3 Reads
3.453 Impact Factor

Secretory Carcinoma of the Thyroid Gland: Report of a Highly Aggressive Case Clinically Mimicking Undifferentiated Carcinoma and Review of the Literature.

Head Neck Pathol 2018 Dec 18. Epub 2018 Dec 18.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, 3020D Vanderbilt University Hospital, 1211 Medical Center Drive, Nashville, TN, 37232-7415, USA.

After being described in the salivary glands as a malignancy with features essentially identical to those of the breast, secretory carcinoma (SC) (formerly mammary analogue SC) has now been identified in other sites including the skin, lung, and thyroid gland. In the breast, SC has a relatively favorable prognosis. Likewise when arising in the salivary glands, it is generally considered to be a low to intermediate grade carcinoma; however, there is a range of clinical behavior with occasional patients dying of progressive disease. Read More

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http://dx.doi.org/10.1007/s12105-018-0995-2DOI Listing
December 2018
1 Read

Targeted next-generation sequencing of cancer-related genes in thyroid carcinoma: A single institution's experience.

Oncol Lett 2018 Dec 2;16(6):7278-7286. Epub 2018 Oct 2.

Department of Biology and Genetics, Laboratory of Cancer Medical Science, Hokuto Hospital, Obihiro, Hokkaido 080-0833, Japan.

Thyroid carcinoma (TC) has characteristic genetic alterations, including point mutations in proto-oncogenes and chromosomal rearrangements that vary by histologic subtype. Recent developments in next-generation sequencing (NGS) technology enable simultaneous analysis of cancer-associated genes of interest, thus improving diagnostic accuracy and allowing precise personalized treatment for human cancer. A total of 50 patients who underwent thyroidectomy between 2014 and 2016 at Hokuto Hospital were enrolled. Read More

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http://dx.doi.org/10.3892/ol.2018.9538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256352PMC
December 2018
2 Reads

NCCN Guidelines Insights: Thyroid Carcinoma, Version 2.2018.

J Natl Compr Canc Netw 2018 Dec;16(12):1429-1440

Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center-James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

The NCCN Guidelines for Thyroid Carcinoma provide recommendations for the management of different types of thyroid carcinoma, including papillary, follicular, Hürthle cell, medullary, and anaplastic carcinomas. These NCCN Guidelines Insights summarize the panel discussion behind recent updates to the guidelines, including the expanding role of molecular testing for differentiated thyroid carcinoma, implications of the new pathologic diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features, and the addition of a new targeted therapy option for V600E-mutated anaplastic thyroid carcinoma. Read More

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http://www.jnccn.org/lookup/doi/10.6004/jnccn.2018.0089
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http://dx.doi.org/10.6004/jnccn.2018.0089DOI Listing
December 2018
12 Reads
4.178 Impact Factor

Liposomal Delivery of miR-34b-5p Induced Cancer Cell Death in Thyroid Carcinoma.

Cells 2018 Dec 11;7(12). Epub 2018 Dec 11.

Cancer Molecular Pathology, School of Medicine, Griffith University, Gold Coast, Queensland 4222, Australia.

This study aims to determine the functional roles of microRNA-34b-5p (miR-34b) in the suppression of anaplastic thyroid carcinoma. We used hydration-of-freeze-dried-matrix (HFDM) formulated liposomes (liposome-loaded miR-34b) for effective delivery of miR-34b to anaplastic thyroid carcinoma in vitro and in vivo. Real time polymerase chain was used to determine the level of miR-34b. Read More

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http://www.mdpi.com/2073-4409/7/12/265
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http://dx.doi.org/10.3390/cells7120265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315437PMC
December 2018
3 Reads

MiR-19a Overexpression in FTC-133 Cell Line Induces a More De-Differentiated and Aggressive Phenotype.

Int J Mol Sci 2018 Dec 7;19(12). Epub 2018 Dec 7.

Department of Biomedical and Biotechnological Sciences, Physiology Section, University of Catania, Catania 95123, Italy.

In recent years, microRNAs (miRNAs) have received increasing attention for their important role in tumor initiation and progression. MiRNAs are a class of endogenous small non-coding RNAs that negatively regulate the expression of several oncogenes or tumor suppressor genes. MiR-19a, a component of the oncogenic miR-17-92 cluster, has been reported to be highly expressed only in anaplastic thyroid cancer, the most undifferentiated, aggressive and lethal form of thyroid neoplasia. Read More

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http://dx.doi.org/10.3390/ijms19123944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320980PMC
December 2018

Circular RNA EIF6 (Hsa_circ_0060060) sponges miR-144-3p to promote the cisplatin-resistance of human thyroid carcinoma cells by autophagy regulation.

Aging (Albany NY) 2018 Dec;10(12):3806-3820

Department of General Surgery, First Hospital of Shanxi Medical University, Taiyua, Shanxi 030001, China.

Anaplastic thyroid carcinoma (ATC) responds for the majority of death of thyroid carcinoma and often causes chemotherapy resistance. We investigated the influence of circEIF6 (Hsa_circ_0060060) on the cisplatin-sensitivity in papillary thyroid carcinoma (PTC) and ATC cells, and explored its regulation to downstream molecules miR-144-3p and Transforming Growth Factor α (TGF-α). Differentially expressed circRNAs in PTC were analyzed using the GSE93522 data downloaded. Read More

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http://www.aging-us.com/article/101674/text
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http://dx.doi.org/10.18632/aging.101674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326687PMC
December 2018
5 Reads

Effect of Combined Epigenetic Treatments and Ectopic NIS Expression on Undifferentiated Thyroid Cancer Cells.

Anticancer Res 2018 Dec;38(12):6653-6662

Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Background: Poorly differentiated (PDTC) and anaplastic thyroid (ATC) cancer cells are characterized by the acquisition of epigenetic abnormalities, leading to the silencing of both the sodium iodide co-transporter and the Coxsackie adenovirus receptor. As aberrant histone acetylation and DNA methylation represent epigenetic mechanisms involved in neoplastic transformation, our study investigated the anticancer properties of epigenetic modifiers in thyroid carcinoma.

Materials And Methods: The cytotoxicity and gene expression modulation of histone deacetylase and DNA methyltransferase inhibitors were evaluated in both PDTC and ATC. Read More

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http://dx.doi.org/10.21873/anticanres.13032DOI Listing
December 2018
2 Reads

Mediastinal seminoma presenting as a neck mass falsely diagnosed as anaplastic thyroid carcinoma: A case report.

Diagn Cytopathol 2018 Nov 23. Epub 2018 Nov 23.

Department of Lab Medicine and Pathology - Histopathology Section, Hamad Medical Corporation, Doha, State of Qatar.

Germ cell tumors can occur in the mediastinum. They account for about 20% of tumors at this location. The majority are located in the anterior mediastinum and usually occur in young adult males. Read More

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http://dx.doi.org/10.1002/dc.24090DOI Listing
November 2018
12 Reads

Understanding Malignancies of the Thyroid Gland: Institutional Experience.

Indian J Otolaryngol Head Neck Surg 2018 Dec 5;70(4):482-489. Epub 2018 Sep 5.

1Department of Otolaryngology and Head Neck Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

To study the epidemiological, pathological characters and determine survival in patients diagnosed of having thyroid gland malignancies. Retrospective chart review of patients having thyroid gland malignancies, which were managed by the two senior authors at our tertiary care institute from January 2000 to December 2006, were performed and evaluated in terms of various clinical, operative and histological parameters. Patients in which follow up of at least 10 years are available were included in the study. Read More

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http://dx.doi.org/10.1007/s12070-018-1492-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224818PMC
December 2018
8 Reads

MEK inhibition induces therapeutic iodine uptake in a murine model of anaplastic thyroid cancer.

J Nucl Med 2018 Nov 21. Epub 2018 Nov 21.

University of Bern, Switzerland.

Rationale: Anaplastic thyroid carcinoma (ATC) is refractory to radioiodine therapy in part due to impaired iodine metabolism. We targeted the MAPK and PI3'K pathways with the intent to induce radioiodine uptake for radioiodine treatment of ATC. Human ATC cells were used to evaluate the ability of pharmacological inhibition of the mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways to induce radioiodine uptake. Read More

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http://dx.doi.org/10.2967/jnumed.118.216721DOI Listing
November 2018
10 Reads

The Use of Post-ablation Stimulated Thyroglobulin in Predicting Clinical Outcomes in Differentiated Thyroid Carcinoma - What Cut-off Values Should We Use?

Clin Oncol (R Coll Radiol) 2019 Feb 17;31(2):e11-e20. Epub 2018 Nov 17.

Department of Clinical Oncology, Prince of Wales Hospital, Shatin, Hong Kong, China.

Aims: Recently published international guidelines recommended using the stimulated thyroglobulin (sTg) post-radioactive iodine (RAI) ablation, in conjunction with tumour stage, as a risk stratification factor. The choice of cut-off values for sTg, namely 1 and 10 ng/ml, was, however, largely based on the functional sensitivities of the assays used, with relatively few published data addressing the prognostic impact of alternative cut-off values. Our study aims to provide data on the prognostic value of sTg at different levels of sensitivities and specificities. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09366555183047
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http://dx.doi.org/10.1016/j.clon.2018.10.009DOI Listing
February 2019
15 Reads

Low intensity focused ultrasound (LIFU) triggered drug release from cetuximab-conjugated phase-changeable nanoparticles for precision theranostics against anaplastic thyroid carcinoma.

Biomater Sci 2018 Dec;7(1):196-210

Department of Ultrasound, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province 130033, P. R. China.

Currently, multifunctional nanotechnology is strongly expected to improve the prospect of treatment and diagnosis. In this study, we synthesized epidermal growth factor (EGFR)-targeted phase-changeable polymer nanoparticles (C-HPNs) loaded with two drugs (C225 and 10-HCPT) for specific tumor targeting, synergistic chemotherapy, and ultrasound imaging under low-intensity focused ultrasound (LIFU). Cetuximab (C225), an EGFR-targeted monoclonal antibody, was conjugated on the surface of the nanoparticles, leading to a significantly high binding affinity to EGFR-overexpressing anaplastic thyroid C643 cells both in vitro and in vivo. Read More

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http://xlink.rsc.org/?DOI=C8BM00970H
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http://dx.doi.org/10.1039/c8bm00970hDOI Listing
December 2018
12 Reads

ID Proteins May Reduce Aggressiveness of Thyroid Tumors.

Endocr Pathol 2018 Nov 9. Epub 2018 Nov 9.

Laboratory of Cancer Molecular Genetics, School of Medical Sciences, State University of Campinas (Unicamp), Campinas, SP, Brazil.

ID genes have an important function in the cell cycle, and ID proteins may help identify aggressive tumors, besides being considered promising therapeutic targets. However, their role in thyroid tumors is still poorly understood. We examined ID expression and their correlation with diagnostic and prognostic features aiming to find a clinical application in differentiated thyroid carcinoma (DTC) cases. Read More

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http://link.springer.com/10.1007/s12022-018-9556-1
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http://dx.doi.org/10.1007/s12022-018-9556-1DOI Listing
November 2018
5 Reads

Giant nonfunctioning adrenal tumors: two case reports and review of the literature.

J Med Case Rep 2018 Nov 10;12(1):335. Epub 2018 Nov 10.

Department of Surgery, 424 General Military Hospital of Thessaloniki, Agiou Nikolaou 42, 55132, Kalamaria, Thessaloniki, Greece.

Background: There are an estimated 1-2 cases per million per year of adrenocortical carcinoma in the USA. It represents a rare and aggressive malignancy; it is the second most aggressive endocrine malignant disease after anaplastic thyroid carcinoma. Non-secretory adrenal masses are diagnosed late due to a mass effect or metastatic disease or found incidentally (adrenal incidentalomas). Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-018-1876-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234785PMC
November 2018
6 Reads

[New aspects in thyroid cancer treatment : Highlights of the ASCO Annual Meeting 2018].

HNO 2018 Dec;66(12):896-900

Klinik und Poliklinik für Hals‑, Nasen- und Ohrenheilkunde, Kopf-Hals Chirurgie, Kopf-Hals-Tumorzentrum des Universitären Cancer Center Hamburg (UCCH), Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Deutschland.

Whereas surgical treatment of thyroid carcinoma plays an important role especially in the early stages, a multimodal approach is pursued in the palliative setting, which, in addition to classical chemotherapy primarily involves treatment with tyrosine kinase inhibitors. An analysis of clinical trials and studies presented at the American Society of Clinical Oncology (ASCO) Annual Meeting 2018 is presented. In particular, studies on the treatment of radioiodine-refractory differentiated thyroid cancer, anaplastic thyroid cancer and immunotherapy were selected and analyzed. Read More

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http://link.springer.com/10.1007/s00106-018-0589-z
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http://dx.doi.org/10.1007/s00106-018-0589-zDOI Listing
December 2018
12 Reads

Cystathione β-Synthase Is Increased in Thyroid Malignancies.

Anticancer Res 2018 Nov;38(11):6085-6090

Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.

Background: Cystathione β-synthase (CBS) catalyzes the conversion of homocysteine and cysteine to hydrogen sulfide (HS) and cystathione, via the trans-sulfuration pathway. CBS protein expression levels are increased in several different human malignancies, with increased protein expression correlating with parameters such as tumor stage, anaplasia, metastases, and chemotherapy resistance.

Materials And Methods: This study employed tissue microarrays to examine CBS expression in benign thyroid tissue, thyroid oncocytomas, thyroid follicular adenomas, and in follicular, papillary, anaplastic, and medullary thyroid carcinomas. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.12
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http://dx.doi.org/10.21873/anticanres.12958DOI Listing
November 2018
13 Reads

Meta-analysis of microarray datasets identify several chromosome segregation-related cancer/testis genes potentially contributing to anaplastic thyroid carcinoma.

PeerJ 2018 24;6:e5822. Epub 2018 Oct 24.

Department of Human Anatomy, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China.

Aim: Anaplastic thyroid carcinoma (ATC) is the most lethal thyroid malignancy. Identification of novel drug targets is urgently needed.

Materials & Methods: We re-analyzed several GEO datasets by systematic retrieval and data merging. Read More

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https://peerj.com/articles/5822
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http://dx.doi.org/10.7717/peerj.5822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203939PMC
October 2018
6 Reads

A giant mass in the neck of a young men: a case of anaplastic thyroid cancer.

Pan Afr Med J 2018;30:151. Epub 2018 Jun 20.

Universidad Autonoma de Nuevo Leon, Facultad de Medicina y Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Oncology Service, Department of Internal Medicine, Monterrey, Nuevo Leon, Mexico.

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http://www.panafrican-med-journal.com/content/article/30/151
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http://dx.doi.org/10.11604/pamj.2018.30.151.15156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201609PMC
December 2018
1 Read

Expression of EMT regulators TWIST, SLUG, and SNAIL in follicular thyroid tumours may relate to widely invasive, poorly differentiated, and distant metastasis.

Histopathology 2018 Oct 28. Epub 2018 Oct 28.

Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.

Aims: To assess the expression of EMT regulators in follicular thyroid tumours.

Methods And Results: The expression of E-cadherin (E-CAD) and transcription factors TWIST, SLUG, and SNAIL in follicular thyroid tumours were examined by immunohistochemistry in tissue samples, including 18 follicular adenomas (FA), 12 minimally invasive follicular thyroid carcinomas (MI-FTC), 16 widely invasive follicular thyroid carcinomas (WI-FTC), 10 poorly differentiated follicular thyroid carcinomas (PDTC), and 6 anaplastic thyroid carcinomas (ATC). Metastatic tumour tissues from 6 of these cases were also examined. Read More

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http://doi.wiley.com/10.1111/his.13778
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http://dx.doi.org/10.1111/his.13778DOI Listing
October 2018
6 Reads

High-grade malignant pancreatic neoplasm with sarcomatoid features.

AME Case Rep 2018 22;2:39. Epub 2018 Aug 22.

Department of Pathology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

Sarcomatoid carcinoma is a rare and aggressive form that occur at diverse locations in the body such as upper respiratory tract, upper and lower digestive tracts, genitourinary tract, breast and thyroid glands. However, its occurrence in pancreas has been rarely reported. Sarcomatoid carcinoma of pancreas (SCP) is a high-grade epithelial malignancy composed predominantly of spindle cells often having features suggestive of epithelial derivation without features indicative of a specific line of mesenchymal differentiation. Read More

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http://acr.amegroups.com/article/view/4583/5326
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http://dx.doi.org/10.21037/acr.2018.08.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182016PMC
August 2018
14 Reads

Galectin-3 targeting in thyroid orthotopic tumors opens new ways to characterize thyroid cancer.

J Nucl Med 2018 Oct 25. Epub 2018 Oct 25.

Nuklearmedizinische Klinik und Poliklinik, Technische Universität München, Germany.

Preoperative characterization of thyroid nodules is challenging since thyroid scintigraphy fails to distinguish between benign and malignant lesions. Galectin-3 is widely expressed in the majority of well-differentiated thyroid carcinomas and in a large fraction of undifferentiated thyroid cancer types but not in normal thyrocytes and benign thyroid lesions. Herein, we aimed to validate galectin-3 targeting in thyroid orthotopic tumors otherwise not visible with conventional imaging. Read More

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http://jnm.snmjournals.org/lookup/doi/10.2967/jnumed.118.219
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http://dx.doi.org/10.2967/jnumed.118.219105DOI Listing
October 2018
17 Reads

Detection of Solitary Axillary Lymph Node Metastases from Hürthle Cell Carcinoma of the Thyroid on F-FDG PET/CT.

Nucl Med Mol Imaging 2018 Oct 27;52(5):389-393. Epub 2018 Aug 27.

1Department of Nuclear Medicine, All India Institute of Medical Sciences, E-81, Ansari Nagar (East), AIIMS Campus, New Delhi, 110029 India.

Thyroid carcinoma is the most common neoplasm of endocrine malignancies. Differentiated thyroid carcinoma (DTC) constitutes 90% of the thyroid carcinomas, rest being medullary thyroid carcinoma (MTC), and anaplastic thyroid carcinoma (ATC). Distant metastases occur in up to 10% of patients with DTC. Read More

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http://dx.doi.org/10.1007/s13139-018-0539-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177346PMC
October 2018
3 Reads

Anaplastic Carcinoma Thyroid - A Review on the Management of this Aggressive Cancer.

Gulf J Oncolog 2018 Sep;1(28):37-41

Department of Surgical Oncology, Government Royapettah Hospital, Chennai, India.

Anaplastic carcinoma thyroid is an aggressive malignancy with very poor survival rate. In this study, we reviewed the records of 34 patients with anaplastic carcinoma thyroid in our centre and we divided them into groups T4a, T4b, and T4c. The case records were reviewed for presentation, diagnosis, treatment and follow-up and we analysed the data using statistical methods. Read More

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September 2018
4 Reads

Clinicopathological Spectrum of Anaplastic Carcinoma of Thyroid - 5 Year Experience from a Tertiary Cancer Centre.

Gulf J Oncolog 2018 Sep;1(28):17-22

Dept. of Surgical Oncology, Malabar Cancer Centre, Thalassery. Kannur,Kerala, India.

Background: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and lethal solid tumors known to affect humans. Although ATC accounts for only 1% to 5% of all thyroid tumors, it portends a dismal prognosis with a median survival of 4 to 12 months from the time of diagnosis. In this retrospective review we aim to study the clinical, cytological and histopathological features and management of ATC cases reported in our institution. Read More

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September 2018

Tumor Susceptibility Gene 101 Mediates Anoikis Resistance of Metastatic Thyroid Cancer Cells.

Cancer Genomics Proteomics 2018 Nov-Dec;15(6):473-483

Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand

Background/aim: Resistance to anoikis is a pre-requisite step in metastasis, a major cause of death in patients with cancer, including thyroid cancer. Impairing anoikis resistance is a possible strategy for therapy of metastatic cancer. We, therefore, we aimed to investigate the key players of anoikis resistance. Read More

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http://dx.doi.org/10.21873/cgp.20106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299787PMC
December 2018
5 Reads

Apatinib-induced protective autophagy and apoptosis through the AKT-mTOR pathway in anaplastic thyroid cancer.

Cell Death Dis 2018 Oct 9;9(10):1030. Epub 2018 Oct 9.

Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China.

Apatinib, an inhibitor of vascular endothelial growth factor receptor-2, has been shown to promote anti-cancer action across a wide range of malignancies, including gastric, lung, and breast cancers. Our previous study showed that apatinib increases apoptosis in anaplastic thyroid carcinoma (ATC), but the direct functional mechanism of tumor lethality mediated by apatinib is still unknown. In this study, we demonstrated that apatinib induced both autophagy and apoptosis in human ATC cells through downregulation of p-AKT and p-mTOR signals via the AKT/mTOR pathway. Read More

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http://dx.doi.org/10.1038/s41419-018-1054-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177436PMC
October 2018
2 Reads