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    2606 results match your criteria Thyroid Anaplastic Carcinoma

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    Pediatric, Adolescent, and Young Adult Thyroid Carcinoma Harbors Frequent and Diverse Targetable Genomic Alterations, Including Kinase Fusions.
    Oncologist 2017 Feb 16. Epub 2017 Feb 16.
    Foundation Medicine, Cambridge, Massachusetts, USA.
    Background: Thyroid carcinoma, which is rare in pediatric patients (age 0-18 years) but more common in adolescent and young adult (AYA) patients (age 15-39 years), carries the potential for morbidity and mortality.

    Methods: Hybrid-capture-based comprehensive genomic profiling (CGP) was performed prospectively on 512 consecutively submitted thyroid carcinomas, including 58 from pediatric and AYA (PAYA) patients, to identify genomic alterations (GAs), including base substitutions, insertions/deletions, copy number alterations, and rearrangements. This PAYA data series includes 41 patients with papillary thyroid carcinoma (PTC), 3 with anaplastic thyroid carcinoma (ATC), and 14 with medullary thyroid carcinoma (MTC). Read More

    Expression profile of biomarkers altered in papillary and anaplastic thyroid carcinoma: Contribution of Tunisian patients.
    Bull Cancer 2017 Feb 6. Epub 2017 Feb 6.
    Salah Azaiez Cancer Institute, Department of Immuno-Histo-Cytology Salah Azaiez, Place Bab Saadoun, 1006 Tunis, Tunisia.
    Aims: The objective of this study was to compare the protein expression profile between well-differentiated (papillary) and undifferentiated (anaplastic) thyroid carcinoma in Tunisian patients.

    Methods: This first Tunisian retrospective study concerned data of 38 thyroid cancer cases (19 papillary carcinoma PTC and 19 anaplastic carcinoma ATC) collected at Salah Azaiez Institute of Tunisia. Immunohistochemistry was used to evaluate tumor expression of different molecular markers (p53, Ki67, E-cadherin, cyclin D1, bcl2, S100 and Her-2). Read More

    Combination of SL327 and Sunitinib Malate leads to an additive anti-cancer effect in doxorubicin resistant thyroid carcinoma cells.
    Biomed Pharmacother 2017 Feb 5;88:985-990. Epub 2017 Feb 5.
    Department of Endocrine, Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Shandong, 264000, PR China. Electronic address:
    Background: Receptor tyrosine kinases (RTKs) play crucial roles in numerous cancer cell processes including cell survival, proliferation, and migration. MEK1/2 MAPK kinases are very important for cancer survival and development. Anaplastic thyroid carcinoma (ATC) is a deadly type of thyroid cancer and there are no very effective systemic treatment strategies for ATC so far. Read More

    Anaplastic thyroid carcinoma and foscarnet use in a multitarget treatment documented by 18F-FDG PET/CT: A case report.
    Medicine (Baltimore) 2017 Feb;96(6):e5621
    aDepartment of Experimental Medicine bDepartment of Internal Medicine and Clinical Specialities cDepartment of Radiology, Anatomopathology and Oncology, Sapienza University of Rome, Rome dNuclear Medicine Unit, Department of Interventional Oncology, Azienda Ospedaliera Ospedale di Circolo di Busto Arsizio Varese, Busto Arsizio, Varese, Italy.
    Rationale: The case reported the rapid remission of disease recurrence achieved adding foscarnet, a DNA polymerase inhibitor that interacts with fibroblast growth factor 2, to low molecular weight heparin and sunitinib for the first time in a patient with an anaplastic thyroid cancer (ATC).

    Patient Concerns: A 65-year-old woman with a multinodular goiter referred for a rapid enlargement of a nodule. Histological examination revealed an ATC with a little area of papillary thyroid cancer (PTC). Read More

    Dysadherin specific drug conjugates for the treatment of thyroid cancers with aggressive phenotypes.
    Oncotarget 2017 Jan 30. Epub 2017 Jan 30.
    Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
    Background: EDC1 is a novel type of antibody-drug conjugate which binds and inhibits the Na,K-ATPase on the surface of cancer cells expressing dysadherin. The purpose of this study was to determine the expression of dysadherin in different types of thyroid carcinoma, and evaluate the therapeutic potential of EDC1 for thyroid carcinomas.

    Methods: Thyroid tissues from 158 patients were examined for dysadherin expression and correlation with clinicopathological features. Read More

    Synergistic activity of N-hydroxy-7-(2-naphthylthio) heptanomide and sorafenib against cancer stem cells, anaplastic thyroid cancer.
    Neoplasia 2017 Jan 27;19(3):145-153. Epub 2017 Jan 27.
    Thyroid Cancer Center, Gangnam Severance Hospital, Department of Surgery, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea; Gangnam Severance Hospital, Department of Surgery, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea. Electronic address:
    Anaplastic thyroid carcinoma (ATC) although rare is the most deadly form of thyroid cancer. The fatality rate for ATC is high-pitched, the survival rate at 1 year after diagnosis is <20%. Control of ATC is severely hard and widespread with unpredictability. Read More

    Small interfering RNA (siRNA) against Slug induces apoptosis and sensitizes human anaplastic thyroid carcinoma cells to doxorubicin.
    Cancer Biomark 2017 Jan 20. Epub 2017 Jan 20.
    Department of Oncology, the Affiliated Hospital of Weifang Medical College, Weifang, Shandong, China.
    Objective: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human cancers and often shows resistance to multimodal therapeutic approaches. It has been shown that the transcriptional repressor Slug inhibits the chemotherapeutic agent-induced apoptosis of cancer cells. We evaluated whether targeting of Slug could augment doxorubicin (DOX)-induced apoptosis of ATC cells. Read More

    An adult mouse thyroid side population cell line that exhibits enriched epithelial-to-mesenchymal transition.
    Thyroid 2017 Jan 27. Epub 2017 Jan 27.
    National Cancer Institute, Laboratory of Metabolism, Bethesda, Maryland, United States ;
    Background: Studies of thyroid stem/progenitor cells have been hampered due to the small organ size and lack of tissue, which limits the yield of these cells. A continuous source that allows the study and characterization of thyroid stem/progenitor cells is desired to push the field forward.

    Method: A cell line was established from Hoechst-resistant side population cells derived from mouse thyroid that were previously shown to contain stem/progenitor-like cells. Read More

    Thyroid cancer after hysterectomy on benign indications: Findings from an observational cohort study in Sweden.
    Int J Cancer 2017 Jan 19. Epub 2017 Jan 19.
    The Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
    To investigate the association between hysterectomy and thyroid cancer subtypes based on histopathology. They did a nationwide, population-based, cohort study from 1973 to 2009 in Sweden. All women above 18 years of age during the period between January 1, 1973 and December 31, 2009 from the Register of Population (n = 5. Read More

    Primary squamous cell carcinoma of the thyroid with complete response to radical radiotherapy and concurrent cisplatin-based chemotherapy.
    BMJ Case Rep 2017 Jan 18;2017. Epub 2017 Jan 18.
    Eisenhower Medical Center, Rancho Mirage, California, USA.
    Chemoradiotherapy and/or surgery are both potentially radical treatments for squamous cell carcinomas. Squamous cell carcinomas are considered chemosensitive tumours compared to adenocarcinomas or anaplastic thyroid malignancies. A 76-year-old man was found to have T4bN0M0 primary squamous cell carcinoma of the thyroid with encasement of the internal carotid artery. Read More

    Comprehensive screening for PD-L1 expression in thyroid cancer.
    Endocr Relat Cancer 2017 Feb;24(2):97-106
    Division of Endocrinology and MetabolismDepartment of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    PD-L1 expression is being considered a potential biomarker for response of anti-PD-1 or anti-PD-L1 agents in various tumors. The reported frequency of PD-L1 positivity varies in thyroid carcinomas, and multiple factors may contribute to the variability in PD-L1 positivity. We evaluated the PD-L1 expression in various thyroid cancers on a large scale. Read More

    Undifferentiated Malignant Neoplasm Involving Parotid and Thyroid: Sampling and PAX8 Cross-Reactivity Can Obscure the Diagnosis of Lymphoma.
    Case Rep Pathol 2016 18;2016:3291549. Epub 2016 Dec 18.
    Department of Pathology, University of Tennessee Graduate School of Medicine, Knoxville, TN, USA.
    Poorly differentiated malignant neoplasia arising within the head and neck region may originate from diverse sources. We report a case of a cytologically undifferentiated malignant neoplasm clinically presenting as masses involving thyroid and parotid. Although PAX8 was immunoreactive and thus worrisome for anaplastic thyroid carcinoma, the tumor was eventually proven to represent PAX5 positive diffuse large B-cell lymphoma expressing cross-reactivity with polyclonal PAX8 antibody. Read More

    Lung adenocarcinoma and adrenocortical carcinoma in a patient with multiple endocrine neoplasia type 1.
    Respir Med Case Rep 2017 18;20:77-81. Epub 2016 Dec 18.
    Department of Internal Medicine, Ojiya General Hospital, Niigata, Japan; Center of Diabetes, Endocrinology and Metabolism, Joetsu General Hospital, Niigata, Japan.
    Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder caused by heterozygous germline mutations in the tumor suppressor gene MEN1, which encodes a nuclear protein, menin. MEN1 is characterized by the combined occurrence of tumors involving the pituitary gland, pancreatic islets, and parathyroid glands. Additionally, patients with MEN1 often exhibit adrenal tumors. Read More

    Patterns of Treatment Failure in Anaplastic Thyroid Carcinoma.
    Thyroid 2017 Jan 9. Epub 2017 Jan 9.
    University of Texas M.D. Anderson Cancer Center, Endocrine Neoplasia and Hormonal Disorders , 1515 Holcombe Blvd, unit 1461 , Houston, Texas, United States , 77030 ;
    Background: Anaplastic thyroid cancer (ATC) is one of the most lethal forms of cancer with a high mortality rate. Current guidelines support surgery for resectable ATC followed by external beam radiation therapy (EBRT) with or without chemotherapy. Treatment for those who are unresectable is palliative. Read More

    Primary Thyroid Carcinoma with Low-Risk Histology and Distant Metastases: Clinicopathologic and Molecular Characteristics.
    Thyroid 2017 Feb 1. Epub 2017 Feb 1.
    1 Department of Pathology, Memorial Sloan-Kettering Cancer Center , New York, New York.
    Background: Distant metastases (DM) are a rare occurrence in well-differentiated thyroid carcinoma. The aim of this study was to analyze the clinical, pathologic, and molecular features of primary thyroid carcinoma with low-risk histology that develop DM.

    Methods: A detailed clinicopathologic review and targeted next-generation sequencing were performed on a cohort of well-differentiated thyroid carcinoma lacking gross extrathyroidal extension, extensive vascular invasion, or significant lymph node metastases but exhibiting DM. Read More

    [Thyroid carcinoma, ten-years file].
    Rozhl Chir 2016 ;95(11):394-397
    Introduction: Even though thyroid carcinoma has, in general, a good prognosis and low mortality rate, its incidence, especially the incidence of early forms of the disease has been growing.

    Method: Retrospective analysis of the file of surgeries of documented thyroid carcinoma within the years of 2006-2015.

    Results: Thyroid carcinoma was recorded in 145 of 1820 patients operated for thyreopathy (8%); microcarcinoma (<10mm) was recorded in 64 cases (44. Read More

    Radiation therapy dose is associated with improved survival for unresected anaplastic thyroid carcinoma: Outcomes from the National Cancer Data Base.
    Cancer 2016 Dec 27. Epub 2016 Dec 27.
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
    Background: The outcomes of patients with unresected anaplastic thyroid carcinoma (ATC) from the National Cancer Data Base (NCDB) were assessed, and potential correlations were explored between radiation therapy (RT) dose and overall survival (OS).

    Methods: The study cohort was comprised of patients who underwent either no surgery or grossly incomplete resection. Correlates of OS were explored using univariate analysis and multivariable analysis (MVA). Read More

    Suberoyl bis-hydroxamic acid activates Notch1 signaling and induces apoptosis in anaplastic thyroid carcinoma through p53.
    Oncol Rep 2017 Jan 29;37(1):458-464. Epub 2016 Nov 29.
    Department of Anesthesiology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin National Clinical Research Center for Cancer, Tianjin 300060, P.R. China.
    Anaplastic thyroid cancer (ATC), usually derived from well-differentiated thyroid cancers is one of the most lethal human endocrine malignancies. In the present study, we report that in human ATC tumor tissue samples exist undetectable Notch1 and the active Notch1 intracellular domain could not be detected in ATC-CAL-62 cells. Interesting, suberoyl bis-hydroxamic acid (SBHA) administration could induce Notch1 intracellular domain levels in a dose-dependent manner, coupled with the increase of p53 and p21. Read More

    Most Thyroid Cancers Detected by Sonography Lack Intranodular Vascularity on Color Doppler Imaging: Review of the Literature and Sonographic-Pathologic Correlations for 698 Thyroid Neoplasms.
    J Ultrasound Med 2016 Dec 1. Epub 2016 Dec 1.
    Lenox Hill Radiology, New York, New York, USA.
    Objectives: This study investigated the controversy of whether hypervascularity on color Doppler sonography correlates with thyroid malignancy by reviewing the literature and sonographic-pathologic correlation.

    Methods: Over a 20-year period, 698 thyroid nodules had color Doppler and histopathologic data. Intranodular vascularity was graded 0 to 3+, and histopathologic findings were recorded. Read More

    Clinical presentation, treatment and outcome of anaplastic thyroid carcinoma: results of a multicenter study in Germany.
    Eur J Endocrinol 2016 Dec;175(6):521-529
    Department of Endocrinology and MetabolismUniversity Hospital Essen, University Duisburg-Essen, Essen, Germany
    Context: Anaplastic thyroid carcinoma (ATC) is an orphan disease and confers a dismal prognosis. Standard treatment is not established.

    Objective: The aim of this study is to describe clinical characteristics, current treatment regimens and outcome of ATC and to identify clinical prognostic markers and treatment factors associated with improved prognosis. Read More

    Clinicopathological features of thyroid cancer in the elderly compared to younger counterparts: single-center experience.
    J Endocrinol Invest 2016 Nov 24. Epub 2016 Nov 24.
    Department of Endocrinology and Metabolism, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey.
    Purpose: The incidence of thyroid cancer is increased in elderly patients. It tends to be larger and have more aggressive characteristics in these patients. Our aim was to compare features of thyroid carcinoma in geriatric and non-geriatric patients. Read More

    Initial Experience With Ultrasound Elastography for Diagnosis of Major Salivary Gland Lesions.
    J Ultrasound Med 2016 Dec 25;35(12):2597-2606. Epub 2016 Oct 25.
    Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai Center for Thyroid Diseases, Shanghai, China.
    Objectives: The aim of this study was to evaluate the usefulness of ultrasound elastography, including conventional strain elastography, acoustic radiation force impulse (ARFI)-induced strain elastography, and point shear wave elastography (SWE) for diagnosis of major salivary gland lesions.

    Methods: Forty major salivary gland lesions underwent conventional sonography, conventional strain elastography, ARFI strain elastography, and point SWE before surgery or biopsy. The diagnostic performances of the sonographic and elastographic techniques were assessed with reference to histopathologic results. Read More

    [Study of Medullary Thyroid Carcinoma from a proband].
    Arch Argent Pediatr 2016 Dec;114(6):e421-e424
    Hospital Universitario Miguel Servet, Servicio de Endocrinología Pediátrica, Zaragoza, España.
    Thyroid cancer is an uncommon type of cancer, accounting less than 1% of all cancers in adults, and 0.5-3% of all cancers in children. There are four different types: papillary carcinoma (80-90% of cases), follicular (5-10%), medullary (5%) and anaplastic cell (2-3%). Read More

    Identification of novel therapeutic targets in anaplastic thyroid carcinoma using functional genomic mRNA-profiling: Paving the way for new avenues?
    Surgery 2017 Jan 16;161(1):202-211. Epub 2016 Nov 16.
    Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:
    Background: Currently, anaplastic thyroid carcinoma has a very poor prognosis and there is an unmet need for new therapeutic options. Therefore, this study aims to identify upregulated genes in anaplastic thyroid carcinoma with known drug interactions that could serve as new therapeutic targets.

    Methods: Publicly available microarray expression profiles of anaplastic thyroid carcinoma and normal thyroid tissue were collected. Read More

    Targeting of slug sensitizes anaplastic thyroid carcinoma SW1736 cells to doxorubicin via PUMA upregulation.
    Int J Biochem Mol Biol 2016 30;7(3):48-55. Epub 2016 Sep 30.
    Department of Thyroid Surgery, Affiliated Hospital of Qingdao University Qingdao 266003, China.
    Objective: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human cancers and often shows resistance to multimodal therapeutic approaches. It has been shown that the transcriptional repressor Slug inhibits the chemotherapeutic agent-induced apoptosis of cancer cells. We evaluated whether targeting of Slug could augment doxorubicin (DOX)-induced apoptosis of ATC cells. Read More

    Management of thyroid cancer: United Kingdom National Multidisciplinary Guidelines.
    J Laryngol Otol 2016 May;130(S2):S150-S160
    The Newcastle upon Tyne Hospitals NHS Foundation Trust,Newcastle upon Tyne,UK.
    This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. This paper provides recommendations on the management of thyroid cancer in adults and is based on the 2014 British Thyroid Association guidelines. Recommendations • Ultrasound scanning (USS) of the nodule or goitre is a crucial investigation in guiding the need for fine needle aspiration cytology (FNAC). Read More

    Primary squamous cell carcinoma of the thyroid: a case report.
    Rom J Morphol Embryol 2016 ;57(2 Suppl):831-836
    Department of Endocrinology, University of Medicine and Pharmacy of Craiova, Romania;
    Primary squamous cell carcinoma of the thyroid is a very rare thyroid malignancy (less than 1% of thyroid cancers) with unfavorable clinical evolution and median survival less than one year, due to highly local tumor invasiveness with airway obstruction, metastases and treatment complications. We present a 62-year-old female patient with a fixed, rapidly increasing 5 cm right thyroid nodule, generating compressive signs and significant weight loss, resembling anaplastic thyroid carcinoma. Thyroid hormones, antithyroid antibodies and calcitonin were normal. Read More

    Anticancer activity of all-trans retinoic acid-loaded liposomes on human thyroid carcinoma cells.
    Colloids Surf B Biointerfaces 2017 Feb 4;150:408-416. Epub 2016 Nov 4.
    Department of Health Sciences, University "Magna Græcia" of Catanzaro, Campus Universitario "S. Venuta", Viale S. Venuta, Germaneto, I-88100 Catanzaro, Italy; IRC-FSH-Interregional Research Center for Food Safety & Health, University of Catanzaro "Magna Græcia", Building of BioSciences, V.le Europa, I-88100 Germaneto Catanzaro (CZ), Italy. Electronic address:
    All-trans retinoic acid (ATRA) is an anti-tumor compound, exerting different anti-cancer effects on different types of cancer cells. Unfortunately, retinoids are also characterized by certain side effects following systemic administration, such as the burning of skin and general malaise. The highly variable degree of bioavailability of ATRA plus its tendency to induce its own destruction through metabolic degradation following oral treatment necessitate the development of alternative formulations. Read More

    When Clinical Trial Participation Is Not an Option in the Era of Personalized Medicine: The Case of Two Patients.
    Oncology 2017 8;92(1):55-60. Epub 2016 Nov 8.
    University of Vermont Cancer Center, Burlington, Vt., USA.
    The combination of personalized therapy with immunotherapy might lead to rapid complete remission in patients who are too sick to be eligible for clinical trials. We report 2 such extraordinary responders. A discussion on the use and purpose of clinical trials in this new era of very active anticancer drug discovery concludes that a paradigm shift is urgently needed. Read More

    Knockdown of S100A4 blocks growth and metastasis of anaplastic thyroid cancer cells in vitro and in vivo.
    Cancer Biomark 2016 Sep;17(3):281-291
    Department of Thyroid Surgery, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
    Anaplastic thyroid cancer (ATC) is a locally aggressive type of thyroid tumor with high rate of distant metastases. It is often incurable because it does not respond to radioiodine, radiotherapy, or chemotherapy. With conventional treatment, the median survival is about 6 months; therefore, new treatment options are needed. Read More

    Clinicopathologic Features of Fatal Non-Anaplastic Follicular Cell-Derived Thyroid Carcinomas.
    Thyroid 2016 Nov 7;26(11):1588-1597. Epub 2016 Sep 7.
    1 Department of Pathology, Memorial Sloan Kettering Cancer Center , New York, New York.
    Background: The vast majority of thyroid cancers, in particular the non-anaplastic follicular cell-derived thyroid carcinomas (non-ANA FCDC), are considered indolent tumors with very low mortality. Hence, it is crucial to analyze the subgroup of these patients who die of disease (DOD) in order to identify clinicopathologic features predictive of disease-specific mortality.

    Methods: All non-ANA FCDC operated at a tertiary cancer center between 1985 and 2010 who were DOD were identified and submitted to a meticulous clinicopathologic analysis. Read More

    Genomic Heterogeneity and Exceptional Response to Dual Pathway Inhibition in Anaplastic Thyroid Cancer.
    Clin Cancer Res 2016 Oct 17. Epub 2016 Oct 17.
    The Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
    Purpose: Cancers may resist single-agent targeted therapies when the flux of cellular growth signals is shifted from one pathway to another. Blockade of multiple pathways may be necessary for effective inhibition of tumor growth. We document a case in which a patient with anaplastic thyroid carcinoma (ATC) failed to respond to either mTOR/PI3K or combined RAF/MEK inhibition but experienced a dramatic response when both drug regimens were combined. Read More

    Cell Cycle M-Phase Genes Are Highly Upregulated in Anaplastic Thyroid Carcinoma.
    Thyroid 2017 Feb 15;27(2):236-252. Epub 2016 Dec 15.
    1 Center for Biotechnology and Genomic Medicine, Medical College of Georgia at Augusta University , Augusta, Georgia .
    Background: Anaplastic thyroid carcinoma (ATC) accounts for only 3% of thyroid cancers, yet strikingly, it accounts for almost 40% of thyroid cancer deaths. Currently, no effective therapies exist. In an effort to identify ATC-specific therapeutic targets, we analyzed global gene expression data from multiple studies to identify ATC-specific dysregulated genes. Read More

    Real-Time Genomic Characterization Utilizing Circulating Cell-Free DNA in Patients with Anaplastic Thyroid Carcinoma.
    Thyroid 2017 Jan 29;27(1):81-87. Epub 2016 Nov 29.
    5 Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center , Houston, Texas.
    Background: Anaplastic thyroid carcinoma (ATC) is an aggressive disease that requires rapid diagnosis and multimodality treatment. Recent advances in targeted therapeutics have provided ATC patients with previously unavailable treatment options, which may improve clinical outcomes in the coming years. Continued development of high-throughput next-generation sequencing provides clinicians with an unparalleled ability to characterize the genomic background of tumors in order to guide treatment selection and clinical trial enrollment. Read More

    miR-148a inhibits self-renewal of thyroid cancer stem cells via repressing INO80 expression.
    Oncol Rep 2016 Dec 25;36(6):3387-3396. Epub 2016 Oct 25.
    Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, P.R. China.
    Anaplastic thyroid carcinoma (ATC) is aggressive and lethal with extrathyroidal invasion, distant metastasis, and resistance to conventional therapies. Cancer stem cells (CSCs) are proposed to be responsible for high recurrence rate in ATC. MicroRNAs (miRNAs) have recently been found as an important class of cellular regulators of ATC carcinogenesis. Read More

    Elucidation of the molecular mechanisms of anaplastic thyroid carcinoma by integrated miRNA and mRNA analysis.
    Oncol Rep 2016 Nov 5;36(5):3005-3013. Epub 2016 Sep 5.
    Department of Breast Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China.
    To elucidate the complex molecular mechanisms of anaplastic thyroid carcinoma (ATC), the mRNA and miRNA expression profiles of ATC were systematically explored. A total of 55 common differentially expressed genes (DEGs) were obtained from two mRNA expression datasets including 23 ATC samples and 24 paired normal samples. Gene expression levels of three randomly selected DEGs, VCAN, COL5A1 and KCNJ16, were examined using RT-PCR in 10 ATC samples. Read More

    Metastatic Papillary Thyroid Carcinoma with Multifocal Synchronous Transformation to Anaplastic Thyroid Carcinoma.
    Case Rep Pathol 2016 28;2016:4863405. Epub 2016 Sep 28.
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA.
    Papillary thyroid carcinoma is a common malignancy to affect the thyroid and is typified by a nonaggressive nature and low rates of mortality. In contrast, anaplastic thyroid carcinoma is the most aggressive thyroid malignancy with a mortality rate of nearly 90% and survival typically of only six months after the diagnosis is made. The transformation of papillary thyroid carcinoma to anaplastic thyroid carcinoma is well documented in the literature but is uncommon and in most instances is reported as a case report or small series only. Read More

    Oncocytic variant of poorly differentiated thyroid carcinoma: "Is diagnosis possible by fine-needle aspiration?"
    Cytojournal 2016 13;13:23. Epub 2016 Oct 13.
    Department of Interventional Radiology, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey.
    Poorly differentiated thyroid carcinoma (PDTC) is a very rare entity, and the diagnosis can be made on histopathology specimens. However, recognition of characteristic features of PDTC is significant on fine-needle aspirations (FNAs) to differentiate this entity from well-differentiated and anaplastic thyroid carcinomas. Here, we present an FNA case concordant with "oncocytic variant of PDTC" and discuss whether definitive diagnosis can be given on FNAs to assess the prognosis in clinically inoperable patients. Read More

    Treatment and Prognosis of Anaplastic Thyroid Carcinoma: A Clinical Study of 50 Cases.
    PLoS One 2016 19;11(10):e0164840. Epub 2016 Oct 19.
    Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America.
    Introduction: Although anaplastic thyroid carcinoma (ATC) is rare, it is one of the most aggressive human cancers. The optimal multimodal therapy policy of ATC is still debated, and a standardized treatment strategy remains to be established. This study aimed to evaluate the management aspect and prognosis of ATC. Read More

    Role of YAP-1 in Thyroid Tumor Progression and Outcome.
    Appl Immunohistochem Mol Morphol 2016 Oct 7. Epub 2016 Oct 7.
    *Department of Medical Area, Azienda Ospedaliero-Universitaria Pisana, S. Chiara Hospital Departments of †Surgical, Medical, Molecular Pathology and Critical Area ‡Translational Research and of Medical and Surgical New Technologies §Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
    Context: Yes-associated protein-1 (YAP-1) is a player of the Hippo pathway and is involved in regulating cell proliferation. YAP-1 is overexpressed in papillary and anaplastic thyroid cancers. However, a correlation between YAP-1 expression and outcome in thyroid carcinoma has not been conclusively demonstrated. Read More

    Update on malignancies in children with juvenile idiopathic arthritis in the German BIKER Registry.
    Clin Exp Rheumatol 2016 Nov-Dec;34(6):1113-1120. Epub 2016 Sep 8.
    Charité University Medicine and Epidemiology Unit, German Rheumatism Research Centre, Berlin, Germany.
    Objectives: While tumour necrosis factor (TNF)-α-inhibitor treatment improved outcome of juvenile idiopathic arthritis (JIA) management markedly, concerns have been raised about an association of TNF-α-inhibitor treatment and an increased risk for malignancies especially lymphoma.

    Methods: Cases of suspected malignancies documented in the German Biker Registry are reviewed in detail.

    Results: Until Dec 31, 2015, 3695 JIA patients were prospectively followed with a total of more than 13,198 observation years. Read More

    Surgical treatment for thyroid carcinoma: retrospective study with 811 patients in a Brazilian tertiary hospital.
    Arch Endocrinol Metab 2016 Oct 10;60(5):472-478. Epub 2016 Oct 10.
    Departamento de Cirurgia de Cabeça e Pescoço, Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, SP, Brasil.
    Objective: The aim of the present study was to describe the epidemiologic data, histological type, treatment and follow-up of the 811 patients treated for thyroid cancer in Instituto do Câncer do Estado de São Paulo (ICESP) over 5 years.

    Materials And Methods: Retrospective analyses of electronic chart information.

    Results: There were 679 cases (83. Read More

    Etiopathogenesis of Differentiated Thyroid Carcinomas.
    Open Access Maced J Med Sci 2016 Sep 2;4(3):517-522. Epub 2016 Aug 2.
    Institute of Pathophysiology and Nuclear Medicine "Akademik Isak Tadzer", Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
    Introduction: Thyroid malignomas are a heterogeneous group of neoplasm consisting of most frequent differentiated encountered carcinomas, papillary and follicular thyroid carcinoma, then medullary thyroid carcinoma originating from neuroendocrine calcitonin-producing C-cells and rare forms of thyroid lymphomas arising from intrathyroidal lymphatic tissue, thyroid sarcomas and poorly differentiated anaplastic thyroid carcinoma. There are increasing numbers of epidemiological studies and publications that have suggested increased incidence rate of thyroid carcinomas. We have read, analysed and compare available reviews and original articles investigating different etiological factors in the development of thyroid carcinomas through Google Scholar and PubMed Database. Read More

    Cancer stem cells as a potential therapeutic target in thyroid carcinoma.
    Oncol Lett 2016 Oct 2;12(4):2254-2260. Epub 2016 Aug 2.
    Cell Biology Unit, IOM Ricerca Srl, Viagrande I-95029 Catania, Italy; Department of Experimental Oncology, Mediterranean Institute of Oncology, Viagrande I-95029 Catania, Italy.
    A number of studies have indicated that tumor growth and proliferation is dependent on a small subset of cells, defined as cancer stem cells (CSCs). CSCs have the capability to self-renew, and are involved with cancer propagation, relapse and metastatic dissemination. CSCs have been isolated from numerous tissues, including normal and cancerous thyroid tissue. Read More

    Metachronous anaplastic sarcoma of the kidney and thyroid follicular carcinoma as manifestations of DICER1 abnormalities.
    Hum Pathol 2016 Sep 30. Epub 2016 Sep 30.
    Department of Pathology, Kanagawa Children's Medical Center, Kanagawa 232-8555, Japan. Electronic address:
    Anaplastic sarcoma of the kidney (ASK) is a tumor found in the pediatric age group and shows many histopathological similarities to pleuropulmonary blastoma (PPB). We present a 12-year-old girl diagnosed with ASK and, three years later, with thyroid follicular carcinoma (TFC) with DICER1 abnormalities. Germline insertion/deletion (p. Read More

    MALAT1 Long Non-coding RNA Expression in Thyroid Tissues: Analysis by In Situ Hybridization and Real-Time PCR.
    Endocr Pathol 2017 Mar;28(1):7-12
    Department of Laboratory Medicine and Pathology K4/436, University of Wisconsin School of Medicine and Public Health, Box 8550, Madison, WI, 53792, USA.
    Long non-coding RNAs (lncRNAs) are important for transcription and for epigenetic or posttranscriptional regulation of gene expression and may contribute to carcinogenesis. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), an lncRNA involved in the regulation of the cell cycle, cell proliferation, and cell migration, is known to be deregulated in multiple cancers. Here, we analyzed the expression of MALAT1 on 195 cases of benign and malignant thyroid neoplasms by using tissue microarrays for RNA in situ hybridization (ISH) and real-time PCR. Read More

    Targeted next-generation sequencing for TP53, RAS, BRAF, ALK and NF1 mutations in anaplastic thyroid cancer.
    Endocrine 2016 Dec 1;54(3):733-741. Epub 2016 Oct 1.
    Department of Endocrinology and Metabolism, University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, Essen, 45122, Germany.
    Anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid cancer with a median survival of 4-6 months. Identification of mutations contributing to aberrant activation of signaling cascades in ATC may provide novel opportunities for targeted therapy. Thirty-nine ATC samples were studied by next-generation sequencing (NGS) with an established gene panel. Read More

    TWIST1/miR-584/TUSC2 pathway induces resistance to apoptosis in thyroid cancer cells.
    Oncotarget 2016 Oct;7(43):70575-70588
    IRCCS SDN Spa, 80121 Napoli, Italy.
    TWIST1, a transcription factor, plays a pivotal role in cancer initiation and progression. Anaplastic thyroid carcinoma (ATC) is one of the deadliest human malignancies; TWIST1 is overexpressed in ATC and increases thyroid cancer cell survival, migration and invasion. The molecular mechanisms underlying the effects of TWIST1 are partially known. Read More

    Riedel's Thyroiditis Mimicking as Anaplastic Thyroid Carcinoma: Unusual Presentation.
    Indian J Surg Oncol 2016 Sep 24;7(3):359-62. Epub 2016 Feb 24.
    Department of Endocrinology, Lakeshore Hospital and Research Center, Maradu Kochi, Kerala India.
    Riedel's thyroiditis is a rare inflammatory process which not only involves thyroid gland but also the surrounding vital structures. It may also be associated with various forms of systemic fibrotic disorders. The exact etiology is not known, but currently most favored view is that of a localized form of systemic fibrotic process. Read More

    Anaplastic Transformation in Mandibular Metastases of Follicular Variant of Papillary Thyroid Carcinoma: A Case Report and Review of the Literature.
    Ann Clin Lab Sci 2016 Sep;46(5):552-6
    Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX, USA.
    Anaplastic transformation of well-differentiated thyroid carcinomas at distant metastatic sites is a rare condition. Most cases described in the literature have occurred in the thyroid or regional lymph nodes. We report a case of anaplastic transformation of the follicular variant of papillary thyroid carcinoma in mandibular metastases. Read More

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