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    The effect of plant lectins on the survival and malignant behaviors of thyroid cancer cells.
    J Cell Biochem 2018 Apr 16. Epub 2018 Apr 16.
    Department of Biology, Faculty of Science, Istanbul University, Vezneciler, Istanbul, Turkey.
    Altered or aberrant glycosylation is a common phenomenon in cancer cells and it originates from changes in the expression of the enzymes, glycosyltransferase, and glycosidase which up-regulate in response to some oncogenes in the glycan synthesis pathway. In this present study, it has been aimed to determine the alteration of sialic acid and fucose expressions in the cell surface of human thyroid carcinoma cells and investigate the changes in tumorigenic and malignant characters after treating them with specific plant lectins. Our study showed that the cell surface glycan chains of anaplastic 8305C, follicular FTC-133, and papillary K1 thyroid carcinoma cells were rich in α-2,6, α-2,3, sialic acid, and α-1,6 fucose residues. Read More
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    Early evolutionary divergence between papillary and anaplastic thyroid cancers.
    Ann Oncol 2018 Apr 10. Epub 2018 Apr 10.
    Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital Barcelona, Spain.
    Background: Papillary thyroid cancer (PTC) is the most common thyroid carcinoma and exhibits an almost uniformly good prognosis, while anaplastic thyroid cancer (ATC) is less frequent and is one of the most aggressive cancers usually resistant to conventional treatment. Current hypothesis posits that ATC derives from PTC through the progressive acquisition of a discrete number of genomic alterations and implies that the mutational landscape of ATC resembles that of PTC. However, the clinical behaviour of ATC and PTC is radically different. Read More
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    Anaplastic lymphoma kinase (ALK) gene rearrangements in radiation-related human papillary thyroid carcinoma after the Chernobyl accident.
    J Pathol Clin Res 2018 Apr 6. Epub 2018 Apr 6.
    Bundeswehr Institute of Radiobiology, Munich, Germany.
    Childhood radiation exposure has been associated with increased papillary thyroid carcinoma (PTC) risk. The role of ALK gene rearrangements in radiation-related PTC remains unclear, but STRN-ALK fusions have recently been detected in PTCs from radiation-exposed persons after Chernobyl using targeted next-generation sequencing and RNA-seq. We investigated ALK and RET gene rearrangements as well as known driver point mutations in PTCs from 77 radiation-exposed patients (mean age at surgery 22. Read More
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    Quantitative Analysis of the Benefits and Risk of Thyroid Nodule Evaluation in Patients ≥70 Years Old.
    Thyroid 2018 Apr 2;28(4):465-471. Epub 2018 Apr 2.
    2 The Thyroid Section, Division of Endocrinology, Diabetes, and Hypertension, The Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts.
    Background: In older patients, thyroid nodules are frequently detected and referred for evaluation, though usually prove to be benign disease or low-risk cancer. Therefore, management should be guided not solely by malignancy risk, but also by the relative risks of any intervention. Unfortunately, few such data are available for patients ≥70 years old. Read More
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    Combined Effects of Baicalein and Docetaxel on Apoptosis in 8505c Anaplastic Thyroid Cancer Cells via Downregulation of the ERK and Akt/mTOR Pathways.
    Endocrinol Metab (Seoul) 2018 Mar;33(1):121-132
    Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
    Background: Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies. Docetaxel, a microtubule stabilizer, is a common chemotherapeutic agent used to treat various metastatic cancers. However, prolonged use results in various side effects and drug resistance. Read More
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    Thyroid Nodule Management: Thyroid-Stimulating Hormone, Ultrasound, and Cytological Classification System for Predicting Malignancy.
    Cancer Inform 2018 19;17:1176935118765132. Epub 2018 Mar 19.
    Department of Endocrinology, Henri Mondor Hospital, Paris, France.
    Background/objectives: Thyroid nodule (TN) is a common thyroid disorder globally, and the incidence has been increasing in recent decades. The objective of this study was to determine the contribution of thyroid-stimulating hormone (TSH), ultrasound (US), and cytological classification system for predicting malignancy among the surgically excised nodules.

    Design And Methods: A retrospective analysis was performed between January 2012 and December 2014, using data drawn from 1188 patients (15-90 years), who had 1433 TN and fine-needle aspiration in Prince Sultan Military Medical City, Saudi Arabia. Read More
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    Utility of the BRAF p.V600E immunoperoxidase stain in FNA direct smears and cell block preparations from patients with thyroid carcinoma.
    Cancer Cytopathol 2018 Mar 26. Epub 2018 Mar 26.
    Division of Pathology and Laboratory Medicine, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
    Background: The identification of BRAF mutations in thyroid cancer has prognostic and therapeutic implications. Although the gold standard for identifying BRAF mutations is molecular testing, the ability to perform BRAF p.V600E immunostaining on fine-needle aspiration (FNA) samples can facilitate the rapid triaging of patients to treatment options. Read More
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    Management of Anaplastic Thyroid Carcinoma: the Fruits from the ATC Research Consortium of Japan.
    J Nippon Med Sch 2018 ;85(1):18-27
    Department of Thyroid and Endocrinology, Fukushima Medical University School of Medicine.
    Anaplastic thyroid carcinoma (ATC) accounts for only 1 to 2% of all thyroid carcinomas, but it is one of the most lethal neoplasms in humans. To obtain further insights into this "orphan disease," we have established the ATC Research Consortium of Japan (ATCCJ) in 2009. It represents a multicenter registry for ATC that have been treated in Japan. Read More
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    Inhibiting 6-phosphogluconate dehydrogenase reverses doxorubicin resistance in anaplastic thyroid cancer via inhibiting NADPH-dependent metabolic reprogramming.
    Biochem Biophys Res Commun 2018 04 14;498(4):912-917. Epub 2018 Mar 14.
    Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address:
    Anaplastic thyroid carcinoma (ATC) is the most aggressive type of thyroid malignancies and resistant to chemotherapy. Little is known on the underlying mechanisms of ATC resistance to chemotherapy. In our work, we identified that 6-phosphogluconate dehydrogenase (6PGD) is critically involved in the development of ATC resistance to doxorubicin. Read More
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    Melatonin suppresses thyroid cancer growth and overcomes radioresistance via inhibition of p65 phosphorylation and induction of ROS.
    Redox Biol 2018 Jun 1;16:226-236. Epub 2018 Mar 1.
    Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:
    Thyroid cancer is the most common endocrine carcinoma with increasing incidence worldwide and anaplastic subtypes are frequently associated with cancer related death. Radioresistance of thyroid cancer often leads to therapy failure and cancer-related death. In this study, we found that melatonin showed potent suppressive roles on NF-κB signaling via inhibition of p65 phosphorylation and generated redox stress in thyroid cancer including the anaplastic subtypes. Read More
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    A study of clinicopathological characteristics of thyroid carcinoma at a Tertiary Care Center.
    J Cancer Res Ther 2018 Jan-Mar;14(2):357-360
    Department of Pathology, Mahavir Cancer Sansthan, Patna, Bihar, India.
    Context: To share clinicopathological data of thyroid carcinoma from a high volume Tertiary Care Centre in East India.

    Aim: To share the epidemiology and clinicopathological presentation of thyroid cancer at a high volume Tertiary Care Center in East India.

    Settings And Design: Retrospective observational study. Read More
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    Identification of metastatic papillary thyroid carcinoma in FNA specimens using thyroid peroxidase immunohistochemistry.
    Cytopathology 2018 Mar 6. Epub 2018 Mar 6.
    Histopathology Department, Sullivan Nicolaides Pathology, Brisbane, Qld, Australia.
    Introduction: We evaluated immunohistochemical staining for thyroid peroxidase (TPO), a glycoprotein found in the apical plasma membrane of thyroid follicular cells, as a marker for metastatic PTC in FNA samples and compared results with thyroglobulin (Tg) and thyroid transcription factor 1 (TTF1) staining.

    Methods: Cell block sections prepared from 100 FNA specimens were stained with a rabbit monoclonal antibody to TPO (EP159). The FNAs included 64 metastatic malignancies from non-thyroid primary sites, including 18 lung, and 36 cases of thyroid tumours (29 PTC, six cases of medullary thyroid carcinoma and one thyroid anaplastic carcinoma). Read More
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    Effects of miR-144 on the sensitivity of human anaplastic thyroid carcinoma cells to cisplatin by autophagy regulation.
    Cancer Biol Ther 2018 Mar 5:1-13. Epub 2018 Mar 5.
    c Department of General Surgery , Shanxi Medical University , Taiyuan , Shanxi , China.
    Background: We investigated the influence of miR-144 on the cisplatin-sensitivity of anaplastic thyroid carcinoma (ATC) cells and explored the internal molecular mechanism of miR-144.

    Methods: Thyroid cancer cells ARO, TPC1 and normal thyroid cells HT-ori3 were used in this research. Expressions of miR-144 and TGF-α were uncovered by western blot and qRT-PCR. Read More
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    Thyroid carcinoma producing β-human chorionic gonadotropin shows different clinical behavior.
    Pathol Int 2018 Apr 15;68(4):207-213. Epub 2018 Feb 15.
    Department of Pathology, Shandong University School of Basic Medical Sciences, 44#, Wenhua Xi Road, Jinan, Shandong, 250012, PR China.
    Columnar cell variant of papillary thyroid carcinoma (CCV-PTC) is an unusual neoplasm, the clinical behavior of which mainly depends on the encapsulation or infiltration. Patients with extensive extrathyroidal extension usually have an aggressive biological behavior. This study confirmed that beta-human chorionic gonadotropin (β-hCG) secreting invasive CCV-PTC has good prognosis comparing with a cohort of follicular cell differentiated thyroid carcinoma. Read More
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    Cytokeratin-8 in Anaplastic Thyroid Carcinoma: More Than a Simple Structural Cytoskeletal Protein.
    Int J Mol Sci 2018 Feb 14;19(2). Epub 2018 Feb 14.
    Departments of Otolaryngology, Molecular and Cellular Physiology, Feist-Weiller Cancer Center, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA
    Anaplastic thyroid carcinoma (ATC) is almost universally fatal. Elevated keratin-8 (KRT8) protein expression is an established diagnostic cancer biomarker in several epithelial cancers (but not ATC). Several keratins, including KRT8, have been suggested to have a role in cell biology beyond that of structural cytoskeletal proteins. Read More
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    Anaplastic thyroid carcinoma in Denmark 1996-2012: A national prospective study of 219 patients.
    Cancer Epidemiol 2018 Apr 4;53:65-71. Epub 2018 Feb 4.
    Odense University Hospital, Department of ENT, Head & Neck Surgery, Sdr Boulevard 29, 5000 Odense C, Denmark. Electronic address:
    Background: Anaplastic thyroid carcinoma (ATC) is the least common but most malignant thyroid cancer. We aimed to examine the characteristics as well as evaluate the incidence, prognostic factors, and if introduction of a fast track cancer program might influence survival in a cohort of ATC patients.

    Methods: A cohort study based on prospective data from the national Danish thyroid cancer database DATHYRCA and the national Danish Pathology Register including 219 patients diagnosed from 1996 to 2012, whom were followed until death or through September 2014. Read More
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    Treatment and survival vary by race/ethnicity in patients with anaplastic thyroid cancer.
    Cancer 2018 Apr 6;124(8):1780-1790. Epub 2018 Feb 6.
    Department of Otolaryngology-Head and Neck Surgery, Emory University, Atlanta, Georgia.
    Background: Anaplastic thyroid cancer (ATC) is the rarest type of thyroid cancer and has the lowest overall survival. To the authors' knowledge, the impact of socioeconomic status and race/ethnicity has not yet been described.

    Methods: Data regarding 719 patients diagnosed with their first primary malignant ATC from January 1, 1998 to December 31, 2011 in the Surveillance, Epidemiology, and End Results program registries were examined. Read More
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    Ionizing Radiation Deregulates the MicroRNA Expression Profile in Differentiated Thyroid Cells.
    Thyroid 2018 Mar;28(3):407-421
    1 Istituto di Endocrinologia ed Oncologia Sperimentale-CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli "Federico II," Naples, Italy .
    Background: Ionizing radiation (IR) is a well-known risk factor for papillary thyroid cancer, and it has been reported to deregulate microRNA expression, which is important to thyroid carcinogenesis. Therefore, this study investigated the impact of IR on microRNA expression profile of the normal thyroid cell line (FRTL-5 CL2), as well as its effect on radiosensitivity of thyroid cancer cell lines, especially the human anaplastic thyroid carcinoma cell line (8505c).

    Methods: The global microRNA expression profile of irradiated FRTL-5 CL2 cells (5 Gy X-ray) was characterized, and data were confirmed by quantitative real-time polymerase chain reaction evaluating the expression of rno-miR-10b-5p, rno-miR-33-5p, rno-miR-128-1-5p, rno-miR-199a-3p, rno-miR-296-5p, rno-miR-328a-3p, and rno-miR-541-5p in irradiated cells. Read More
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    Circulating BRAF Levels Correlate with Treatment in Patients with Thyroid Carcinoma.
    Thyroid 2018 Mar 27;28(3):328-339. Epub 2018 Feb 27.
    1 Department of Surgery, Massachusetts General Hospital , Boston, Massachusetts.
    Background: BRAF is the most common mutation in papillary thyroid carcinoma (PTC) and can be associated with aggressive disease. Previously, a highly sensitive blood RNA-based BRAF assay was reported. The objective of this study was to assess the correlation of BRAF circulating tumor RNA levels with surgical and medical treatment. Read More
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    Simultaneous detection of single-nucleotide variant, deletion/insertion, and fusion in lung and thyroid carcinoma using cytology specimen and an RNA-based next-generation sequencing assay.
    Cancer Cytopathol 2018 Mar 24;126(3):158-169. Epub 2018 Jan 24.
    Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
    Background: Molecular testing for epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) and ROS proto-oncogene 1, receptor tyrosine kinase (ROS1) fusion is routinely performed in patients with stage IV lung adenocarcinoma to assess their eligibility for targeted therapy. Fine-needle aspiration (FNA)-derived material frequently is the only pathologic material available. The identification of genomic aberrations in thyroid nodules from FNA smears may help stratify cancer risk and spare patients from a second surgery. Read More
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    Demographic and Clinical Features of Thyroid Carcinomas in Republic of Macedonia (1999-2010).
    Open Access Maced J Med Sci 2017 Dec 17;5(7):1005-1010. Epub 2017 Oct 17.
    Institute of Pathology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
    Background: Thyroid carcinomas (TC) are the most common endocrine malignancies. In some parts of the world, the incidence of TCs has increased over the past few decades, especially in females according to some studies.

    Aim: We have set as the objective for our study to analyse the demographic, ultrasound features, thyroid hormonal status and frequency of thyroid carcinomas in the Republic of Macedonia according to histopathological type. Read More
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    Anaplastic Thyroid Cancer With Extensive Skeletal Muscle Metastases on 18F-FDG PET/CT.
    Clin Nucl Med 2018 Apr;43(4):e113-e114
    From the Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University, Stanford, CA.
    A 61-year-old woman with newly diagnosed anaplastic thyroid cancer and known metastases to the brain, lungs, and adrenal glands complained of groin muscle pain. F-FDG PET/CT was performed to assess for extent of disease and showed extensive hypermetabolic lesions throughout the skeletal musculature concerning for metastatic disease. As this would be a very rare presentation for anaplastic thyroid carcinoma, a biopsy of the left gluteal muscle was conducted. Read More
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    Long-term effects of crizotinib in ALK-positive tumors (excluding NSCLC): A phase 1b open-label study.
    Am J Hematol 2018 May 8;93(5):607-614. Epub 2018 Feb 8.
    Seoul National University Hospital, Seoul, South Korea.
    Crizotinib, an inhibitor of anaplastic lymphoma kinase (ALK), MET, and ROS1, is approved for treatment of patients with ALK-positive or ROS1-positive advanced non-small-cell lung cancer (NSCLC). However, ALK rearrangements are also implicated in other malignancies, including anaplastic large-cell lymphoma and inflammatory myofibroblastic tumors (IMTs). In this ongoing, multicenter, single-arm, open-label phase 1b study (PROFILE 1013; NCT01121588), patients with ALK-positive advanced malignancies other than NSCLC were to receive a starting dose of crizotinib 250 mg twice daily. Read More
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    ATRA increases iodine uptake and inhibits the proliferation and invasiveness of human anaplastic thyroid carcinoma SW1736 cells: Involvement of β-catenin phosphorylation inhibition.
    Oncol Lett 2017 Dec 19;14(6):7733-7738. Epub 2017 Oct 19.
    Department of Genitourinary, Cancer Medicine, MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA.
    All-trans-retinoic acid (ATRA) can enhance iodine uptake capability of thyroid tumors, but the mechanisms remain poorly understood. The aim of the present study was to investigate the effects of ATRA on isotope susceptibility, proliferation and invasion of anaplastic thyroid carcinoma (ATC) and potential mechanisms. SW1736 cells were treated with 1 µmol/l ATRA or 1% ethanol for 5 days. Read More
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    Immunohistochemical Biomarkers of Mesenchymal Neoplasms in Endocrine Organs: Diagnostic Pitfalls and Recent Discoveries.
    Endocr Pathol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
    Mesenchymal neoplasms rarely present in or adjacent to endocrine organs. In this context, the recognition of these rare tumor types can be challenging, with significant potential for misdiagnosis as sarcomatoid carcinomas (i.e. Read More
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    Sulforaphene Enhances The Efficacy of Photodynamic Therapy In Anaplastic Thyroid Cancer Through Ras/RAF/MEK/ERK Pathway Suppression.
    J Photochem Photobiol B 2018 Feb 11;179:46-53. Epub 2017 Dec 11.
    Beckman Laser Institute Korea, Dankook University, Cheonan 31116, Republic of Korea; Department of Pre-medical Science, Dankook University, Cheonan 31116, Republic of Korea. Electronic address:
    Sulforaphene (SFE), a natural isothiocyanate from cruciferous vegetables has shown a potential anticancer effect against cervical and lung cancer. Palliative treatments like photodynamic therapy (PDT) are being implemented for a long time however, the results are still not promising in case of aggressive cancers like anaplastic thyroid cancer. The objective of this work is to establish an alternative method with the combination of photofrin-PDT and sulforaphene, a natural isothiocyanate from cruciferous vegetables, against human anaplastic thyroid cancer to enhance the efficacy of PDT. Read More
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    Radiofrequency ablation of primary thyroid carcinoma: efficacy according to the types of thyroid carcinoma.
    Int J Hyperthermia 2018 Jan 24:1-6. Epub 2018 Jan 24.
    a Department of Radiology and Research Institute of Radiology , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
    Objective: To evaluate the efficacy of ultrasound (US)-guided radiofrequency ablation (RFA) according to the types of thyroid carcinoma, particularly in patients with a high-surgical risk.

    Materials And Methods: Eight patients with nine tumours of pathologically proven papillary and anaplastic carcinoma were treated by US-guided RFA. Patients with primary thyroid carcinoma were divided into three groups; group (1) Anaplastic carcinoma, group (2) papillary macrocarcinoma, and group (3) papillary microcarcinoma. Read More
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    Anaplastic thyroid carcinoma with rapid thyrotoxicosis - a case report and the literature review.
    Endokrynol Pol 2018 10;69(1):28-31. Epub 2018 Jan 10.
    Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University.
    Introduction: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human malignancies and constitutes approximately 1.6-5% of the malignant neoplasms of the thyroid gland. ATC usually manifests itself with the local symptoms due to a rapidly enlarging thyroid mass, and as other thyroid cancers, has only seldom been reported to cause thyrotoxicosis. Read More
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    targets angiogenesis and EMT concurrently in anaplastic thyroid carcinoma.
    Endocr Relat Cancer 2018 Mar 9;25(3):323-337. Epub 2018 Jan 9.
    Cancer Molecular PathologySchool of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia
    The current study aims to evaluate for the first time the inhibitory roles of in the pathogenesis of anaplastic thyroid carcinoma. In addition, we investigated the mechanisms by which miR-205 regulates angiogenesis and epithelial-to-mesenchymal transition (EMT) in cancer. Two anaplastic thyroid carcinoma cell lines were transfected with the expression vector pCMV- Selected markers of angiogenesis and EMT including vascular endothelial growth factor A () and zinc finger E-box-binding homeobox 1 () were investigated by Western blot. Read More
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    Anaplastic thyroid carcinoma: review of treatment protocols.
    Endocr Relat Cancer 2018 Mar 2;25(3):R153-R161. Epub 2018 Jan 2.
    Department of EndocrinologyDiabetology and Metabolism, Endocrine Tumour Center at West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
    Anaplastic thyroid carcinoma (ATC) is an orphan disease and in most patients fatal. So far no established treatment is available that prolongs survival. Several large retrospective studies have identified negative prognostic markers, analyzed efficacy of multimodal approaches such as radiotherapy with and without concurrent chemotherapy and chemotherapy protocols. Read More
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    Effects of HuR downregulation on anaplastic thyroid cancer cells.
    Oncol Lett 2018 Jan 30;15(1):575-579. Epub 2017 Oct 30.
    Department of Internal Medicine and Medical Specialties, 'Sapienza' University of Rome, I-00161 Rome, Italy.
    Anaplastic thyroid cancer (ATC) constitutes one of the most aggressive types of human solid cancer, and is characterized by the absence of thyroid differentiation features and a marked degree of invasiveness. We have previously demonstrated that the RNA-binding protein Hu antigen R (HuR) is overexpressed in thyroid carcinoma; thus, the biological role of this RNA-binding protein was investigated in the present study using the ATC cell lines SW1736 and 8505C. In both cell lines, HuR protein levels were higher compared with in the non-tumorigenic thyroid cell line Nthy-ori-3. Read More
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    Gene Fusions in Thyroid Cancer.
    Thyroid 2018 Feb;28(2):158-167
    1 Research Centre for Medical Genetics , Moscow, Russian Federation.
    Background: Gene fusions are known in many cancers as driver or passenger mutations. They play an important role in both the etiology and pathogenesis of cancer and are considered as potential diagnostic and prognostic markers and possible therapeutic targets. The spectrum and prevalence of gene fusions in thyroid cancer ranges from single cases up to 80%, depending on the specific type of cancer. Read More
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    A Case of Thyroid Papillary Carcinoma: Remarkable Decrease in Multiple Lung Metastases within 40 Years after a Single Administration of Radioiodine without Thyroidectomy and with Later Anaplastic Transformation.
    Case Rep Oncol 2017 Sep-Dec;10(3):928-937. Epub 2017 Oct 17.
    Department of Radiology, Graduate School of Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Differentiated thyroid carcinoma is an uncommon malignancy of childhood and adolescence that is unique because it has an overall favorable prognosis despite its relatively high rate of nodal and distant metastases. Total thyroidectomy and positive I therapy are recommended for cases with pulmonary metastases. In contrast, anaplastic thyroid cancer is one of the most aggressive malignancies that have an unfavorable and miserable prognosis. Read More
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    EZH2 Overexpression as a Useful Prognostic Marker for Aggressive Behaviour in Thyroid Cancer.
    In Vivo 2018 Jan-Feb;32(1):25-31
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan.
    Background/aim: Enhancer of zeste homolog 2 (EZH2) is a member of the polycomb group of genes, which are key factors in the regulation of cell proliferation and differentiation. EZH2 is overexpressed in many malignancies. We analyzed EZH2 protein expression levels in different histological subtypes of thyroid cancer to examine its utility as a prognostic factor. Read More
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    Comparison of sonographic characteristics of primary thyroid lymphoma and anaplastic thyroid carcinoma.
    J Thorac Dis 2017 Nov;9(11):4774-4784
    Department of Ultrasound, Fatou Community Health Center, Beijing 100023, China.
    Background: Although primary thyroid lymphoma (PTL) and anaplastic thyroid carcinoma (ATC) both account for a rare portion of the morbidity of all thyroid malignancies, the therapeutic methods and prognosis for these two diseases are different. The purpose of this study was to investigate the sonographic characteristics of PTL and ATC and to compare the sonographic findings of PTL and ATC.

    Methods: The study included 42 patients with histopathologically proven PTL (n=27) and ATC (n=15). Read More
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    Mediastinal Lymph Node Metastases in Thyroid Cancer: Characteristics, Predictive Factors, and Prognosis.
    Int J Endocrinol 2017 12;2017:1868165. Epub 2017 Nov 12.
    Department of Head & Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
    Background: Mediastinal lymph node metastases (MLNM) have not been extensively studied. The aim of this study is to investigate the characteristics, predictive factors, and prognosis of MLNM in thyroid cancer.

    Methods: This is a retrospective study based on the thyroid cancer patients with MLNM at our institution from 2008 to 2015. Read More
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    BET bromodomain inhibitor JQ1 modulates microRNA expression in thyroid cancer cells.
    Oncol Rep 2018 Feb 12;39(2):582-588. Epub 2017 Dec 12.
    Department of Medical Area, University of Udine, I-33100 Udine, Italy.
    Anaplastic thyroid carcinoma (ATC) represents the most lethal thyroid cancer sub-type, currently unresponsive to standard treatments. Recently, bromodomain and extra-terminal (BET) proteins have emerged as attractive therapeutic targets in several diseases, including cancer. In different cancer models, the anti-neoplastic activity of BET inhibitors such as JQ1, I-BET762 and I-BET151 have already been established, due to both direct and indirect effects. Read More
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    Imaging of Anaplastic Thyroid Carcinoma.
    AJNR Am J Neuroradiol 2017 Dec 14. Epub 2017 Dec 14.
    From the Departments of Diagnostic Radiology (S.A., T.V., D.F.S., J.M.D.).
    Anaplastic thyroid carcinoma is fatal if unresectable. However, improved survival has been reported after gross total resection and multimodality therapy. In this report, we describe the contrast-enhanced high-resolution CT characteristics of anaplastic thyroid carcinoma in 57 patients. Read More
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    Special types of thyroid carcinoma.
    Histopathology 2018 Jan;72(1):40-52
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Perelman School of Medicine, Philadelphia, PA, USA.
    This article reviews the small percentage of thyroid tumours that are not classified as classic papillary thyroid carcinoma, follicular thyroid carcinoma, and medullary thyroid carcinoma. It includes subtypes of papillary thyroid carcinoma, including, tall-cell, hobnail/micropapillary, columnar cell, diffuse sclerosing and solid variants. Poorly differentiated carcinoma, high-grade carcinoma and anaplastic thyroid carcinoma are reviewed. Read More
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    Molecular pathology of thyroid tumours of follicular cells: a review of genetic alterations and their clinicopathological relevance.
    Histopathology 2018 Jan;72(1):6-31
    Anatomical Pathology, Molecular Diagnostic Unit, University of Bologna School of Medicine, Azienda USL di Bologna, Bologna, Italy.
    Thyroid cancer is the most common endocrine malignancy. Knowledge of the molecular pathology of thyroid tumours originating from follicular cells has greatly advanced in the past several years. Common molecular alterations, such as BRAF p. Read More
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    Insight into Differentiated Thyroid Cancer Gross Pathological Specimen Shrinkage and Its Influence on TNM Staging.
    Eur Thyroid J 2017 Nov 26;6(6):315-320. Epub 2017 Jul 26.
    Polyclinique Les Fleurs, Service Imagerie Médicale, Ollioules, France.
    Introduction: This study aimed at comparing thyroid cancer staging when taking into account the differences between the "T" assessment" using ultrasound (US) and histopathological measurements.

    Material And Methods: This retrospective study included all consecutive differentiated follicular thyroid cancer (DTC) and medullary thyroid cancer (MTC) patients who underwent postoperative histopathological staging assessment at a single institution. Anaplastic thyroid carcinomas were excluded from the present study. Read More
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    Posterior Reversible Encephalopathy Syndrome after Lenvatinib Therapy in a Patient with Anaplastic Thyroid Carcinoma.
    Intern Med 2018 Apr 8;57(7):1015-1019. Epub 2017 Dec 8.
    Department of Otorhinolaryngology, Fukui Red Cross Hospital, Japan.
    Posterior reversible encephalopathy syndrome (PRES) is a rare reversible neurological syndrome that causes subcortical vasogenic brain edema and which is associated with the use of target-specific agents. Lenvatinib is a target-specific agent that was recently approved for inoperable thyroid cancer. We herein describe the case of a 66-year-old woman with anaplastic thyroid cancer (ATC) who was treated with lenvatinib and who subsequently developed PRES. Read More
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    Inhibition of X-linked inhibitor of apoptosis protein suppresses tumorigenesis and enhances chemosensitivity in anaplastic thyroid carcinoma.
    Oncotarget 2017 Nov 28;8(56):95764-95772. Epub 2017 Sep 28.
    The Fourth Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People's Republic of China.
    Anaplastic thyroid carcinoma (ATC) is one of the most lethal carcinoma with a poor prognosis; however, molecular mechanisms underlying the aggressiveness of ATC remain unclear. Our goal was to examine the expression of X-linked inhibitor of apoptosis protein (XIAP) in ATC, as well as its role in ATC tumorigenesis. This is a retrospective study of ATC patients from the Second Affiliated Hospital of Harbin Medical University during June 2003 to October 2013. Read More
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    Effects of nutraceuticals on anaplastic thyroid cancer cells.
    J Cancer Res Clin Oncol 2018 Feb 2;144(2):285-294. Epub 2017 Dec 2.
    Department of Medical Area, University of Udine, 33100, Udine, Italy.
    Purpose: The anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid cancer with a high mortality rate. Since nutraceuticals may exert beneficial effects on tumor biology, here, effects of four of these compounds [resveratrol, genistein, curcumin and epigallocatechin-3-gallate (EGCG)] on ATC cell lines were investigated.

    Methods: Two ATC-derived cell lines were used: SW1736 and 8505C. Read More
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    Apatinib Inhibits Angiogenesis Via Suppressing Akt/GSK3β/ANG Signaling Pathway in Anaplastic Thyroid Cancer.
    Cell Physiol Biochem 2017 1;44(4):1471-1484. Epub 2017 Dec 1.
    Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Background/aims: Anaplastic thyroid carcinoma (ATC) is one of the most lethal human malignancies, and there is no efficient method to slow its process. Apatinib, a novel tyrosine kinase inhibitor (TKI), has been confirmed for its efficacy and safety in the treatment of advanced gastric carcinoma patients. However, the effects of Apatinib in ATC are still unknown. Read More
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    AKT activity is elevated in aggressive thyroid neoplasms where it promotes proliferation and invasion.
    Exp Mol Pathol 2017 12 21;103(3):288-293. Epub 2017 Nov 21.
    Department of Pathology and Laboratory Medicine, University of Wisconsin, School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792, USA. Electronic address:
    The PI3K/AKT/mTOR signaling pathway controls major cellular processes such as cell growth, proliferation and survival. Stimulation of this pathway leads to AKT phosphorylation and activation, resulting in phosphorylation of mTOR and myriad other targets. AKT upregulation has been implicated in thyroid cancer pathogenesis and is a candidate treatment target for patients with advanced disease that has not responded to traditional therapies. Read More
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    Expression of cancer/testis antigens MAGE-A, MAGE-C1, GAGE and CTAG1B in benign and malignant thyroid diseases.
    Oncol Lett 2017 Dec 26;14(6):6485-6496. Epub 2017 Sep 26.
    Division of Pathology Diagnostic Services, Cytology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
    Despite considerable advances in the understanding of thyroid gland biology, correctly diagnosing thyroid nodules and treating high-grade thyroid carcinoma remains challenging. Cancer/testis (CT) antigens have emerged as potential diagnostic tools as well as targets of potential cancer vaccinations. In the present study, a total of 117 patients who underwent surgical therapy for thyroid disease were available for analysis. Read More
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