10,437 results match your criteria Thymoma


Quantitative Thoracic Magnetic Resonance Criteria for the Differentiation of Cysts from Solid Masses in the Anterior Mediastinum.

Korean J Radiol 2019 May;20(5):854-861

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Objective: To evaluate quantitative magnetic resonance imaging (MRI) parameters for differentiation of cysts from and solid masses in the anterior mediastinum.

Materials And Methods: The development dataset included 18 patients from two institutions with pathologically-proven cysts (n = 6) and solid masses (n = 12) in the anterior mediastinum. We measured the maximum diameter, normalized T1 and T2 signal intensity (nT1 and nT2), normalized apparent diffusion coefficient (nADC), and relative enhancement ratio (RER) of each lesion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3348/kjr.2018.0699DOI Listing

Image-guided Fine Needle Aspiration Cytology of Intrathoracic Lesions.

J Cytol 2019 Apr-Jun;36(2):106-110

Department of Pulmonary Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Mangalore, Karnataka, India.

Background: Percutaneous, image-guided transthoracic fine needle aspiration cytology (TTFNAC) is a rapid, yet accurate, and well-established diagnostic method used in the cytological evaluation of intrathoracic lesions. The study was done to determine the utility of image-guided TTFNAC in diagnosis of intrathoracic lesions.

Subjects And Methods: A retrospective analysis of all cases who underwent image-guided TTFNAC of a suspected intrathoracic lesion, in a tertiary care hospital was done over a period of 3 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/JOC.JOC_187_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425786PMC

Third distant recurrence of benign thymoma in a patient with myasthenia gravis.

BMJ Case Rep 2019 Apr 14;12(4). Epub 2019 Apr 14.

Thoracic Surgery, Albany Medical Center Hospital, Albany, New York, USA.

Myasthenia gravis (MG) is an autoimmune disease where antibodies attack the presynaptic terminals at the neuromuscular junction causing progressive weakness. Associated with thymomas, resection can improve symptoms. A 29-year-old woman with MG who underwent two previous thymectomies, at ages 11 and 15 presented 14 years later with recurrent MG symptoms and an anterior mediastinal mass. Read More

View Article

Download full-text PDF

Source
http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22852
Publisher Site
http://dx.doi.org/10.1136/bcr-2018-228529DOI Listing
April 2019
1 Read

A study of comorbidities in myasthenia gravis.

Acta Neurol Belg 2019 Apr 10. Epub 2019 Apr 10.

Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareily Road, Lucknow, Uttar Pradesh, 226014, India.

Management of myasthenia gravis (MG) in the presence of comorbidities may be difficult. We report the effect of comorbidities in the outcome of MG. The patients with MG during 1991-2016 were included and evaluated including their demographic variables, clinical findings, Myasthenia Gravis Foundation of America (MGFA) score. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s13760-019-01102-w
Publisher Site
http://dx.doi.org/10.1007/s13760-019-01102-wDOI Listing
April 2019
6 Reads

Pathological discrepancies in the diagnosis of thymic epithelial tumors: the Tallinn-Lyon experience.

J Thorac Dis 2019 Feb;11(2):456-464

Université Lyon 1, Université de Lyon, Hospices Civils de Lyon, Lyon (Bron) 69677, France.

Background: Thymic epithelial tumors are rare thoracic tumors for which pathological diagnosis is challenging due to the definition of multiple subtypes, tumor heterogeneity, and variations in interobserver reproducibility. In this study, we aimed at analyzing the quality of pathological reporting in line with the consistency between initial diagnosis and final diagnosis after expert review through a collaboration between the largest thoracic oncology center in Estonia, and one expert center in France.

Methods: Hospital electronic database and pathology databases from the Tallinn North Estonia Medical Centre were searched for thymic and mediastinal tumors from 2010 to 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/jtd.2018.12.123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409262PMC
February 2019
1 Read

Microscopic polyangiitis associated with thymic tumor: a case report and review of the literature.

BMC Nephrol 2019 Apr 8;20(1):123. Epub 2019 Apr 8.

Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, 3-20-1 Chuo, Ami, Ibaraki, 300-0395, Japan.

Background: Thymic hyperplasia and thymic epithelial tumor (thymoma) have been associated with a variety of autoimmune diseases. Renal involvement has been reported in patients with thymoma. Minimal change disease and membranous nephropathy are frequently observed in glomerular lesions of thymoma patients, but ANCA-associated renal vasculitis is rare. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1319-9DOI Listing
April 2019
1 Read

Thymic papillary adenocarcinoma coexisting with type A thymoma: A case report.

Int J Surg Case Rep 2019 Mar 30;57:142-144. Epub 2019 Mar 30.

Thoracic Surgery, Shimonoseki City Hospital, Shimonoseki, Japan.

Introduction: Thymic papillary adenocarcinoma is rare. Further, thymic papillary adenocarcinoma coexisting with type A thymoma is extremely rare. Surgery remains the only effective treatment for this disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijscr.2019.03.039DOI Listing
March 2019
1 Read

Nomogram to predict thymoma prognosis: A population-based study of 1312 cases.

Thorac Cancer 2019 Apr 7. Epub 2019 Apr 7.

Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: A thymoma is a common cancer within the anterior mediastinum; however, the prognostic characteristics have not been established. The aim of this study was to identify the prognostic factors and develop a nomogram for the prognostic prediction of patients with thymoma based on data from the Surveillance, Epidemiology, and End Results (SEER) database.

Methods: Patients with thymomas diagnosed between 1983 and 2014 were selected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1759-7714.13059DOI Listing
April 2019
1 Read

A case of immune thrombocytopenia associated with invasive thymoma successfully treated with eltrombopag.

Blood Res 2019 Mar 21;54(1):74-79. Epub 2019 Mar 21.

Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5045/br.2019.54.1.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439297PMC
March 2019
1 Read

Utilization of Minimally Invasive Thymectomy and Margin Negative Resection for Early Stage Thymoma.

Ann Thorac Surg 2019 Apr 3. Epub 2019 Apr 3.

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas; Center for Innovations In Quality, Effectiveness, and Safety, Michael E. DeBakey VA Medical Center, Houston, Texas.

Background: Minimally invasive thymectomy (MIT) has demonstrated improved short-term outcomes compared with open thymectomy (OT). While adoption of MIT for thymoma is increasing, oncologic outcomes have not been well-characterized.

Methods: Retrospective cohort study of adult patients from the National Cancer Database who underwent MIT or OT for Masaoka stage I-II thymoma between 2010-2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.athoracsur.2019.03.010DOI Listing
April 2019
1 Read

Subacute Sensory Ataxic Neuronopathy With Thymoma Presenting Marked Improvement After Steroid Therapy.

Front Neurol 2019 20;10:268. Epub 2019 Mar 20.

Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan.

Subacute sensory ataxic neuronopathy is a well-known form of paraneoplastic syndrome. Most sensory neuronopathies are associated with small cell lung cancer and anti-Hu antibodies, and usually show only slight improvement with immunotherapy. To date, there have been few reports of neuropathy associated with thymoma and no treatment strategy has been established for thymoma-related neuropathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2019.00268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435522PMC
March 2019
1 Read

[Thoracoscopy in combined treatment of thymoma (in Russian only)].

Khirurgiia (Mosk) 2019 (3):84-87

Research Institute of Oncology, Tomsk National Research Medical Center, Tomsk, Russia.

The experience of video-assisted thoracoscopic interventions for thymus tumors in the Research Institute of Oncology of Tomsk National Research Medical Center is presented. We also evaluate the features of postoperative management of these patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17116/hirurgia201903184DOI Listing
January 2019
1 Read

Alteration in gene expression profiles of thymoma: Genetic differences and potential novel targets.

Thorac Cancer 2019 Apr 1. Epub 2019 Apr 1.

Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China, Tianjin's Clinical Research Center for Cancer, Tianjin, China.

Background: This study was conducted to investigate the gene expression profiles associated with thymoma to better understand the molecular mechanism underlying the pathogenesis of thymoma.

Methods: Eight patients with thymomas (type A, AB, B1, and B2) and four controls with thymic cysts were analyzed using microarray profiling to identify changes in gene expression.

Results: Across all of our samples, 2319 messenger RNAs were upregulated and 2776 were downregulated in thymomas relative to thymic cysts. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/1759-7714.13
Publisher Site
http://dx.doi.org/10.1111/1759-7714.13053DOI Listing
April 2019
7 Reads

Non-Myasthenia Gravis Immune Syndromes and the Thymus: Is There a Role for Thymectomy?

Thorac Surg Clin 2019 May 7;29(2):215-225. Epub 2019 Mar 7.

Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University Hospitals and Clinics, 300 Pasteur Drive, Stanford, CA 94305, USA. Electronic address:

Thymectomy has long been considered, performed, and discussed for many different nonmyasthenic immune syndromes. Thymectomy is now an established treatment for MG, and has been performed for other immune syndromes with varying degrees of improvement. Although numerous reports document immune syndromes' association with thymoma, few address the role of thymectomy in symptom resolution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.thorsurg.2018.12.008DOI Listing
May 2019
2 Reads

Surgical Decision Making: Thymoma and Myasthenia Gravis.

Thorac Surg Clin 2019 May 7;29(2):203-213. Epub 2019 Mar 7.

Thoracic Surgery Unit, Department of Cardiologic, Thoracic and Vascular Sciences, University Hospital, Padova, Italy. Electronic address:

About 15% of patients with myasthenia gravis are affected by thymoma. Precise tumor staging is necessary to plan the appropriate operation. In early stages, complete surgical resection is the mainstay of treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.thorsurg.2018.12.007DOI Listing
May 2019
2 Reads

Surgical Techniques for Myasthenia Gravis: Robotic-Assisted Thoracoscopic Surgery.

Thorac Surg Clin 2019 May;29(2):177-186

Department of Surgery, Competence Center of Thoracic Surgery, Charité University Hospital Berlin, Charitéplatz 1, Berlin 10117, Germany. Electronic address:

Robotic-assisted thoracoscopic surgery (RATS) creates an extended approach for thymectomy in terms of locating contralateral phrenic nerve and upper poles of the thymus. RATS thymectomy is indicated in all non-thymomatous myasthenia gravis (MG) patients and thymomatous MG patients with resectable thymoma, typically Masaoka-Koga I and II. Left-sided RATS thymectomy is superior for anatomic reasons and in the special care patients with MG. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.thorsurg.2018.12.006DOI Listing
May 2019
2 Reads

Surgical Techniques for Myasthenia Gravis: Video-Assisted Thoracic Surgery.

Thorac Surg Clin 2019 May 7;29(2):165-175. Epub 2019 Mar 7.

Myasthenia Gravis Multidisciplinary Program, Tor Vergata University, Viale Oxford 81, Rome 00133, Italy; Department of Surgical Sciences, Tor Vergata University, Via Montpellier 1, Rome 00133, Italy; Division of Thoracic Surgery, Tor Vergata University Policlinic, Viale Oxford 81, Rome 00133, Italy. Electronic address:

We describe the various video-assisted thoracic surgery approaches to the thymus currently adopted in nonthymomatous and thymomatous myasthenic patients. Despite several controversies, video-assisted thoracic surgery thymectomy gained worldwide popularity. Classic 3-port approaches proved safe and effective. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.thorsurg.2018.12.005DOI Listing
May 2019
5 Reads

History of Thymectomy for Myasthenia Gravis.

Authors:
Joel D Cooper

Thorac Surg Clin 2019 May;29(2):151-158

Department of Surgery, Hospital of the University of Pennsylvania, 3400 Spruce Street, 6 White, Philadelphia, PA 19104, USA. Electronic address:

In the early 1900s, chance observations of improved symptoms in several myasthenic patients undergoing thyroidectomy for goiters with concomitant resection of the adjacent thymus gland, first suggested a possible association between the thymus and myasthenia gravis. With the remarkable progress made in the understanding and treatment of myasthenia and in the anesthetic, surgical, and postoperative management of patients undergoing thoracic procedures, the initial high morbidity and mortality associated with thymectomy have been all but eliminated, and thymectomy is frequently incorporated into the long-term management strategy of this disease. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15474127183016
Publisher Site
http://dx.doi.org/10.1016/j.thorsurg.2018.12.011DOI Listing
May 2019
7 Reads

Long-Term Outcomes After Surgical Resection for Pleural Dissemination of Thymoma.

Ann Surg Oncol 2019 Mar 28. Epub 2019 Mar 28.

Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Japan.

Background: Cases of thymoma with pleural dissemination are occasionally encountered, and their management is difficult. Some reports have noted that surgical treatment for dissemination is effective, although the long-term results and clinical course details remain unclear. The current study investigated the short- and long-term outcomes of surgical resection of pleural dissemination. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07330-xDOI Listing
March 2019
1 Read

Cytometric cell-based assays for anti-striational antibodies in myasthenia gravis with myositis and/or myocarditis.

Sci Rep 2019 Mar 27;9(1):5284. Epub 2019 Mar 27.

Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

The purposes of the present study were to identify anti-striational antibodies in myasthenia gravis (MG) patients with myositis and/or myocarditis using a combination of cell-based assays and flow cytometry (cytometric cell-based assays) and to describe the main clinical implications. Among 2,609 stored samples collected from all over Japan between 2003 and 2016, we had serum samples from 30 MG patients with myositis and/or myocarditis. Cytometric cell-based assays with titin, ryanodine receptor, and voltage-gated Kv1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-41730-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437199PMC
March 2019
2 Reads

An update on thymectomy in myasthenia gravis.

Expert Rev Neurother 2019 Apr 5:1-11. Epub 2019 Apr 5.

b Fondazione Policlinico Gemelli , IRCCS , Roma , Italy.

Introduction: Myasthenia gravis (MG) is one of the best treatable autoimmune diseases. However, in most patients, treatment is necessarily long-term and related side effects are a serious burden. Thymectomy has a special place in the disease management as a non-pharmacological disease-modifying therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1600404DOI Listing
April 2019
1 Read

Effect of Diaphragm Plication in Thymoma Patients with and without Myasthenia Gravis.

Tanaffos 2018 Mar;17(3):177-182

Lung Disease Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Thymoma is the most common tumor of the anterior mediastinum that has the most effective treatment, as it can be completely resected. In patients with advanced stage, phrenic nerve involvement can be seen and suggested treatment for these patients is unilateral phrenic excision and diaphragm plication. However in patients with myasthenia gravis, there are concerns in relation to this method of treatment. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428380PMC
March 2018
1 Read

Primary immunodeficiencies in adults.

Authors:
Jiří Litzman

Vnitr Lek 2019 ;65(2):109-116

In contrast to general opinion, the issue of primary immunodeficiency is far from just a pediatric medicine; a large number of patients with primary immunodefciencies are not only treated, but also diagnosed in adulthood. The most important manifestation of these diseases are serious, unusual or ill-treatable infections. Some primary immune deficiency diseases manifest themselves in adulthood - mainly common variable immunodeficiency (CVID) and Goods syndrome (hypogammaglobulinemia with thymoma). Read More

View Article

Download full-text PDF

Source
January 2019
1 Read

A previously undescribed cutaneous paraneoplastic syndrome in a cat with thymoma.

Vet Dermatol 2019 Mar 25. Epub 2019 Mar 25.

Department of Small Animal Teaching Hospital, The Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, EH25 9RG, Scotland, UK.

Background: Exfoliative dermatitis is a well-recognized cutaneous paraneoplastic syndrome (PNS) associated with thymoma in cats, of which the clinical and histopathological presentation has been well-characterized.

Objectives: To describe a novel clinical skin manifestation associated with thymoma in a cat.

Animal: A 14-year-old neutered female domestic short hair cat. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/vde.12745
Publisher Site
http://dx.doi.org/10.1111/vde.12745DOI Listing
March 2019
10 Reads

Immunodeficiency associated with tumour pathology: Good's syndrome.

BMJ Case Rep 2019 Mar 20;12(3). Epub 2019 Mar 20.

Department of Allergy, Hospital Universitario Nuestra Senora de la Candelaria, Santa Cruz de Tenerife, Spain.

The Good's syndrome (GS) is a low prevalence entity where thymoma often is associated with immunodeficiency. Patients may start presenting recurrent rhinosinusal infections, bronchopulmonary infections, haematological alterations and diarrhoea, secondary to immunodeficiency. They can also present respiratory symptoms and parathymic syndromes derived from the existence of thymoma, a slow-growing neoplasm located in the anterior mediastinum. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-227970DOI Listing
March 2019
1 Read

Activation of the mTOR/ Akt pathway in thymic epithelial cells derived from thymomas.

PLoS One 2019 21;14(3):e0197655. Epub 2019 Mar 21.

IVPC UMR754 INRA, Univ Lyon, Université Claude Bernard Lyon 1, EPHE, Lyon, France.

The pathogenesis of thymic epithelial tumors remains poorly elucidated. The PIK3/Akt/mTOR pathway plays a key role in various cancers; interestingly, several phase I/II studies have reported a positive effect of mTOR inhibitors in disease control in thymoma patients. A major limit for deciphering cellular and molecular events leading to the transformation of thymic epithelial cells or for testing drug candidates is the lack of reliable in vitro cell system. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197655PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428316PMC
March 2019
1 Read
3.234 Impact Factor

Hyperthermic Intrathoracic Chemotherapy (HITHOC) for Pleural Malignancies-Experience from Indian Centers.

Indian J Surg Oncol 2019 Feb 11;10(Suppl 1):91-98. Epub 2018 Dec 11.

Department of Surgical Oncology, Zydus Hospital, Zydus hospital road, SG highway, Thaltej, Ahmedabad, 380054 India.

Hyperthermic intrathoracic chemotherapy (HITHOC) has been used in addition to radical surgery for primary and secondary pleural malignancies to improve local control, prolong survival, and improve the quality of life. This study was performed to study the indications, methodology, perioperative outcomes, and survival in patients undergoing HITHOC at Indian centers. A retrospective analysis of prospectively collected demographic and clinical data, perioperative and survival data of patients undergoing surgery with or without HITHOC was performed. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s13193-018-0859-y
Publisher Site
http://dx.doi.org/10.1007/s13193-018-0859-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397125PMC
February 2019
7 Reads

Ganciclovir Therapeutic Drug Monitoring: A Case Series.

Ther Drug Monit 2019 04;41(2):107-110

Departments of Clinical Pharmacy and Pharmacology.

This article presents 3 cases of immunocompromised patients for whom therapeutic drug monitoring of ganciclovir in combination with cytomegalovirus viral load measurement was used to guide treatment. The first patient is diagnosed with thymoma A, the second is a heart transplant recipient, and the third is an HIV-positive patient. These patients were all diagnosed with cytomegalovirus and treated with ganciclovir. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FTD.0000000000000598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426343PMC
April 2019
2 Reads

Predicting pathological subtypes and stages of thymic epithelial tumors using DWI: value of combining ADC and texture parameters.

Eur Radiol 2019 Mar 15. Epub 2019 Mar 15.

Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Military Medical University of PLA Airforce (Fourth Military Medical University), Xi'an, 710038, Shaanxi, People's Republic of China.

Objectives: To explore the value of combining apparent diffusion coefficients (ADC) and texture parameters from diffusion-weighted imaging (DWI) in predicting the pathological subtypes and stages of thymic epithelial tumors (TETs).

Methods: Fifty-seven patients with TETs confirmed by pathological analysis were retrospectively enrolled. ADC values and optimal texture feature parameters were compared for differences among low-risk thymoma (LRT), high-risk thymoma (HRT), and thymic carcinoma (TC) by one-way ANOVA, and between early and advanced stages of TETs were tested using the independent samples t test. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00330-019-06080-4DOI Listing
March 2019
1 Read

Micronodular thymoma with lymphoid stroma diagnosed 10 years after the first operation: a case report.

J Med Case Rep 2019 Mar 16;13(1):69. Epub 2019 Mar 16.

Division of Thoracic Surgery, Respiratory Disease Center, Seirei Mikatahara General Hospital, 3453, Mikatahara-cho, Kita-ku Hamamatsu, Shizuoka, Japan.

Introduction: Micronodular thymoma with lymphoid stroma is a rare subtype of thymoma. Here we report a case of micronodular thymoma with lymphoid stroma that was completely resected after incomplete resection 10 years earlier.

Case Presentation: A 70-year-old Japanese woman who had undergone resection for a thymic cyst 10 years earlier was found to have a solid nodule with a multilocular lesion at the site of the previous operation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13256-019-2006-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420736PMC
March 2019
1 Read

Anti-Amphiphysin-associated limbic encephalitis in a 72-year-old patient with aortic angiosarcoma.

BMJ Case Rep 2019 Mar 14;12(3). Epub 2019 Mar 14.

Department of Neurology, University Hospital Schleswig-Holstein, Lübeck, Germany.

Paraneoplastic autoimmune encephalopathic syndromes have been described most often in association with small cell lung cancer or breast cancer, tumours of the ovaries, testes, lymphoma and thymoma. Antibodies associated with paraneoplastic encephalopathies are, among others, anti-Hu, anti-Ma2 and, in part, anti-N-methyl-D-aspartate(NMDA)-receptor antibodies. Here, we present the case of a 72-year-old patient hospitalised due to progressive cognitive decline and disorientation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-226798DOI Listing
March 2019
3 Reads

Multiomics Analysis Reveals that GLS and GLS2 Differentially Modulate the Clinical Outcomes of Cancer.

J Clin Med 2019 Mar 13;8(3). Epub 2019 Mar 13.

Department of Surgery, Konkuk University Medical Centre, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea.

Kidney-type glutaminase () and liver-type glutaminase () are dysregulated in many cancers, making them appealing targets for cancer therapy. However, their use as prognostic biomarkers is controversial and remains an active area of cancer research. Here, we performed a systematic multiomic analysis to determine whether glutaminases function as prognostic biomarkers in human cancers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm8030355DOI Listing

Carbonic anhydrase 9 expression is associated with poor prognosis, tumor proliferation, and radiosensitivity of thymic carcinomas.

Oncotarget 2019 Feb 12;10(13):1306-1319. Epub 2019 Feb 12.

Education and Research Support Center, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.

Introduction: Thymic epithelial tumors (TETs) comprise several histologies of thymoma and thymic carcinomas (TCs), and TC frequently metastasizes and causes death. We therefore aimed here to identify key molecules closely related to prognosis and their biological roles in high-risk TETs, particularly TCs.

Results: RNA sequence analysis demonstrated that hypoxia-related genes were highly expressed in TETs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.26657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407679PMC
February 2019
1 Read

Occurrence of acute pulmonary embolism induced by recombinant erythropoietin during treatment of pure red cell aplasia associated with thymoma: A case report.

Medicine (Baltimore) 2019 Mar;98(10):e14789

Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Rationale: Thymoma is a type of rare tumor in the thymus gland, and among patients with thymoma, less than 10% will develop pure red cell aplasia (PRCA), whereas less than 5% of patients with PRCA have a thymoma. The optimal approach for PRCA in thymoma is immunosuppressive therapy, such as steroids, cyclosporine, and human antithymocyte globulin.

Patient Concerns: A sixty-one-year-old male was diagnosed with thymoma with PRCA after he complained fatigue, tinnitus, and weakness for 1 month, he received therapy with recombinant erythropoietin (rhEPO) for 1 month after the tumor was totally resected and readmitted with pulmonary embolism and received anticoagulation therapy with enoxaparin for 3 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417601PMC
March 2019
1 Read

A practical approach to enrich intact tryptic N-glycopeptides through size exclusion chromatography and hydrophilicity (SELIC) using an acrylamide-agarose composite gel system.

Anal Chim Acta 2019 Jun 1;1058:107-116. Epub 2019 Feb 1.

Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, PR China; Department of Chemistry, Fudan University, Shanghai, 200433, PR China. Electronic address:

Increasing researches proved that abnormal glycosylation is strongly correlated with many diseases. Specially, site-specific glycosylation and its associated heterogeneity are closely related to the function and activity of the glycoprotein. However, intact N-glycopeptide analysis still faces great challenges because the presence of highly abundant non-glycosylated peptides would suppress the ionization of lowly abundant glycopeptides. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aca.2019.01.044DOI Listing
June 2019
2 Reads

Paraneoplastic relapsing minimal change disease associated with type A thymoma in an elderly patient: A case report and literature review.

Med J Malaysia 2019 Feb;74(1):97-98

National University Health System, Department of Medicine, Singapore.

Thymoma is a rare mediastinal tumour that can be accompanied by different paraneoplastic syndromes. Here we report a case of Type A thymoma associated with relapsing minimal change disease (MCD). This case highlights: (1) The need to balance rapid prednisolone weaning against risk for relapse in an elderly patient at risk for steroid-induced complications. Read More

View Article

Download full-text PDF

Source
February 2019
1 Read

Neoantigen identification strategies enable personalized immunotherapy in refractory solid tumors.

J Clin Invest 2019 Mar 5;130. Epub 2019 Mar 5.

Background: Recent genomic and bioinformatic technological advances have made it possible to dissect the immune response to personalized neoantigens encoded by tumor-specific mutations. However, timely and efficient identification of neoantigens is still one of the major obstacles to using personalized neoantigen-based cancer immunotherapy.

Methods: Two different pipelines of neoantigens identification were established in this study: (1) Clinical grade targeted sequencing was performed in patients with refractory solid tumor, and mutant peptides with high variant allele frequency and predicted high HLA-binding affinity were de novo synthesized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI99538DOI Listing
March 2019
1 Read
13.215 Impact Factor

Discovery and validation of DNA methylation markers for overall survival prognosis in patients with thymic epithelial tumors.

Clin Epigenetics 2019 Mar 4;11(1):38. Epub 2019 Mar 4.

Cancer Center, Institute of Surgery Research, Third Affiliated Hospital, Army Medical University (Third Military Medical University), No. 10 Changjiang Zhilu, Yuzhong District, Chongqing, 400042, China.

Background: The current prognosis of thymic epithelial tumors (TETs) is according to the World Health Organization (WHO) histologic classification and the Masaoka staging system. These methods of prognosis have certain limitations in clinical application and there is a need to seek new method for determining the prognosis of patients with TETs. To date, there have been no studies done on the use of DNA methylation biomarkers for prognosis of TETs. Read More

View Article

Download full-text PDF

Source
https://clinicalepigeneticsjournal.biomedcentral.com/article
Publisher Site
http://dx.doi.org/10.1186/s13148-019-0619-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398263PMC
March 2019
4 Reads

Xanthomatous Thymoma.

Am J Clin Pathol 2019 Feb 28. Epub 2019 Feb 28.

Department of Pathology, University of Texas MD Anderson Cancer Center, Houston.

Objectives: Ten cases of thymomas with an extensive xanthomatous component are presented.

Methods: Cases were identified during a review of more than 500 cases of thymomas. Histologic material from surgical resections was evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqz005DOI Listing
February 2019
2 Reads

Genome‑wide DNA methylation profile of thymomas and potential epigenetic regulation of thymoma subtypes.

Oncol Rep 2019 May 28;41(5):2762-2774. Epub 2019 Feb 28.

Central Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China.

The aim of the present study was to examine the whole‑genome DNA methylation status of thymomas and identify differences in thymoma DNA methylation profiles. DNA methylation profiles of tissues (n=12) were studied using the Infinium MethylationEPIC BeadChip microarray (850K) and analyzed in relation to gene expression data. Functional annotation analysis of DNA methylation between the different groups was performed using the online tool GeneCodis3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/or.2019.7035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448127PMC
May 2019
2 Reads
2.191 Impact Factor

Multilobulated thymoma with an acute angle: a new predictor of lung invasion.

Eur Radiol 2019 Feb 26. Epub 2019 Feb 26.

Department of Radiology, Weill Cornell Medicine, New York-Presbyterian Hospital, 525 E. 68th St, Box 141, New York, NY, 10065, USA.

Objective: Imaging features of thymomas such as lobulation, infiltration into lung, and adjacent lung abnormality have been associated with lung invasion but are unreliable. The goal of this study was to develop a more objective and reproducible method for predicting lung invasion by thymomas.

Subjects And Methods: Fifty-four thymomas resected from 2007 to 2017 were included for analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00330-019-06059-1DOI Listing
February 2019

AKT as a Therapeutic Target for Cancer.

Cancer Res 2019 Mar 26;79(6):1019-1031. Epub 2019 Feb 26.

Basic Medical College, Zhengzhou University, Zhengzhou, Henan, China.

Many cellular processes in cancer are attributed to kinase signaling networks. V-akt murine thymoma viral oncogene homolog (AKT) plays a major role in the PI3K/AKT signaling pathways. AKT is activated by PI3K or phosphoinositide-dependent kinases (PDK) as well as growth factors, inflammation, and DNA damage. Read More

View Article

Download full-text PDF

Source
http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-18-2738DOI Listing
March 2019
10 Reads

Thoracoscopic Thymectomy for Large Thymic Cyst: Myasthenia Gravis With Thymoma Concealed by Thymic Cyst.

Surg Laparosc Endosc Percutan Tech 2019 Feb 20. Epub 2019 Feb 20.

Department of Surgery, Division of Chest Surgery.

We herein report a case of myasthenia gravis (MG) in which thoracoscopic thymectomy was performed for a large thymic cystic lesion using a subxiphoid approach. We have previously suggested the usefulness of the subxiphoid approach in thymectomy. The indications of thoracoscopic thymectomy were recently expanded to include large thymic cystic lesions without intraoperative rupture of the lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SLE.0000000000000641DOI Listing
February 2019
1 Read

Case report on intravenous octreotide for the treatment of intraoperative vasoplegia following thymoma resection.

SAGE Open Med Case Rep 2019 8;7:2050313X19827744. Epub 2019 Feb 8.

The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Octreotide is a somatostatin analog known for its role in the treatment of acute variceal bleeding, enterocutaneous fistula and carcinoid syndrome. The reduction of portal pressure from splanchnic vasoconstriction has been attributed to the inhibition of nitric oxide synthesis, guanylate cyclase and release of glucagon. Octreotide has many therapeutic applications as a result of the ubiquitous nature of somatostatin receptors throughout the body. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050313X19827744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378416PMC
February 2019
1 Read

PD-1 inhibitor-associated severe myasthenia gravis with necrotizing myopathy and myocarditis.

J Neurol Sci 2019 Apr 13;399:97-100. Epub 2019 Feb 13.

Department of Neurology, Tokyo Women's Medical University, Tokyo, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jns.2019.02.023DOI Listing

Sensitivity and specificity of fine needle aspiration for the diagnosis of mediastinal lesions.

Ann Diagn Pathol 2019 Feb 10;39:69-73. Epub 2019 Feb 10.

Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA. Electronic address:

Fine needle aspiration cytology (FNAC) of mediastinal masses allows for rapid on-site evaluation and the triaging of material for ancillary studies. However, surgical pathology is often considered to be the gold standard for diagnosis. This study examines the sensitivity and specificity of FNAC compared to a concurrent or subsequent surgical pathology specimen in 77 mediastinal lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anndiagpath.2019.02.011DOI Listing
February 2019
2 Reads

Thymic Epithelial Tumors: Prognostic Significance and Relationship between Histology and the New TNM Staging System.

Thorac Cardiovasc Surg 2019 Feb 22. Epub 2019 Feb 22.

Department of Morfology, Experimental Medicine and Surgery, Section of General and Thoracic Surgery, Sant'Anna Hospital, University of Ferrara, Ferrara, Italy.

Background:  This study aims to describe the relationship between the new tumor nodes metastasis (TNM) staging and World Health Organization (WHO) classification and to identify how these two variables relate to each other and whether they possess a prognostic value in predicting survival and recurrence of disease.

Methods:  Medical records of 54 patients who underwent surgery for thymic epithelial tumors between 1996 and 2015 were reviewed.The histologic type of neoplasm was classified according to the criteria of WHO and staging was evaluated using the new TNM classification system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1678612DOI Listing
February 2019
1 Read

Growth of thymic epithelial tumors and thymic cysts: Differential radiological points.

Thorac Cancer 2019 Apr 21;10(4):864-871. Epub 2019 Feb 21.

Department of Radiology, Seoul National University College of Medicine, and Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, South Korea.

Background: The growth rate of thymic epithelial tumors (TETs) and thymic cysts was investigated to determine whether they can be differentiated and clinico-radiological predictors of interval growth was identified.

Methods: This retrospective study included 122 patients with pathologically proven thymic cysts (n = 56) or TETs (n = 66) who underwent two serial chest computed tomography scans at least eight weeks apart. Average diameters and attenuation were measured, volume-doubling times (VDTs) were calculated, and clinical characteristics were recorded. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1759-7714.13016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449257PMC
April 2019
1 Read
1.126 Impact Factor

Who will benefit from thymectomy for myasthenia gravis? Is there any role for this procedure in elderly patients?

Ann Transl Med 2019 Jan;7(1)

Department of Surgery and Clinical Science, Division of Chest Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, Japan.

Background: The proportion of elderly patients with myasthenia gravis (MG) is increasing over time. Thoracoscopic extended thymectomy has been shown to achieve a superior short-term outcome to transsternal procedures. Therefore, the long-term clinical outcome should be re-examined, particularly in elderly patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/atm.2018.11.66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351377PMC
January 2019