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Acta Oncol 2019 Feb 20:1-5. Epub 2019 Feb 20.

a University of Florida Health Proton Therapy Institute , Jacksonville , FL , USA.

Objective: Thymic malignancies (TM) are rare tumors with long-term survivorship, causing concerns for radiotherapy-related late side effects. Proton therapy (PT) reduces the radiation dose to organs at risk, potentially decreasing long-term toxicities while preserving disease control. We report patterns-of-care and early clinical outcomes after PT for thymoma and thymic carcinoma. Read More

Surg Case Rep 2019 Feb 19;5(1):35. Epub 2019 Feb 19.

Department of Thoracic Surgery, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan.

Background: Among anterior mediastinal tumors, a teratoma is known to rupture with growth, but there have been few previous reports about thymoma rupture. We here report a rare case of an invasive thymoma with intrapulmonary and intrathoracic rupture requiring emergency life-saving surgery. To our knowledge, this is the first such case in the literature. Read More

Surg Case Rep 2019 Feb 19;5(1):30. Epub 2019 Feb 19.

Department of Thoracic Surgery, Respiratory Disease Center, Kyoto Katsura Hospital, 17 Yamadahirao-cho Nishikyouku, Kyoto, Japan.

Background: Spontaneous intracystic hemorrhage of cystic thymoma is very rare. We encountered a patient with giant cystic thymoma with spontaneous intracystic hemorrhage and successfully resected the thymoma.

Case Presentation: A 38-year-old man was referred to our hospital with chest pain. Read More

Eur J Cardiothorac Surg 2019 Feb 19. Epub 2019 Feb 19.

Department of Mathematics, Science University of Tokyo, Tokyo, Japan.

Objectives: The tumour, node and the metastasis (TNM) staging system for thymic epithelial tumours was adopted by the Union for International Cancer Control (UICC) in 2016. Although the T factor is defined by the invasive nature of a thymoma, tumour size is not considered. The aim of this study was to examine the clinical importance of tumour size using a nationwide retrospective database of cases treated from 1991 to 2010 compiled by the Japanese Association for Research of the Thymus. Read More

J Clin Apher 2019 Feb 19. Epub 2019 Feb 19.

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas.

Introduction: The primary objective of this study was to assess response to plasma exchange (PLEX) in myasthenia gravis (MG) patients with and without autoantibodies (Ab) to acetylcholine receptor (AChR) or muscle-specific kinase (MuSK). Analysis was also done to determine if correlation existed between sex, early or late onset MG, thymoma, or thymectomy and response to PLEX.

Materials And Methods: Data was analyzed on 58 consecutive MG patients treated with PLEX. Read More

Surg Case Rep 2019 Feb 18;5(1):29. Epub 2019 Feb 18.

Department of Surgery, Japanese Red Cross Okayama Hospital, 2-1-1 Aoe, Kita-ku, Okayama city, Okayama, 700-8607, Japan.

Background: Ectopic hamartomatous thymoma, which usually occurs in the lower neck, is a rare benign tumor containing spindle cells, epithelial nests, and adipose tissue. Although the origin of this tumor is still unknown, recent reports suggest that the designation of this tumor is inappropriate.

Case Presentation: A 38-year-old with an anterior cervical mass in the suprasternal region of her neck was referred to our hospital. Read More

J Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Department of Dermatology, Shiga University of Medical Science, Otsu, Japan.

Thorac Cancer 2019 Feb 13. Epub 2019 Feb 13.

Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Background: Bronchiectasis is a rare complication in patients with thymic neoplasm. The aim of this study was to investigate the clinical and radiological manifestations, laboratory tests, pathologic features, and outcome of treatment of bronchiectasis in patients with thymic neoplasm.

Methods: From January 2000 to January 2018, 20 patients with a diagnosis of thymic neoplasm and bronchiectasis were hospitalized at the Peking Union Medical College Hospital. Read More

J Thorac Dis 2018 Dec;10(12):6475-6481

Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Background: The hemi-clamshell (HCS) approach provides a wide anterior view of the mediastinum as well as outstanding exposure of the pulmonary hilum. Here, we evaluated the utility and outcomes of this approach in cases of advanced thymic malignancy with hilar invasion.

Methods: We performed a retrospective analysis of 14 patients with thymic epithelial malignancy surgically resected with an HCS approach. Read More

SAGE Open Med Case Rep 2019 1;7:2050313X19827749. Epub 2019 Feb 1.

Department of Thoracic and Cardiovascular Surgery, Osaka Medical College Hospital, Takatsuki, Japan.

Thymomas are tumors originating from the thymus epithelial cells and are the most common tumors of the anterior mediastinum. They have been classified into types A, AB, B1, B2, and B3 by the World Health Organization. Type B3 thymoma is composed of epithelial cell sheets with mild to moderate atypia and scant lymphocytes. Read More

J Neurol 2019 Feb 11. Epub 2019 Feb 11.

Laboratorio d'Immunogenetica dei Trapianti, Dipartimento di Oncoematologia e Terapia Cellulare e Genica, IRCCS OPBG, Rome, Italy.

Background: The relative prevalence of myasthenia gravis (MG) subtypes is changing, and their differential features and association with HLA class II alleles are not completely understood.

Methods: Age at onset, presence/absence of autoantibodies (Ab) and thymoma were retrospectively considered in 230 adult Italian patients. Clinical severity, assessed by MGFA scale, and the highest Ab titer were recorded. Read More

Thorac Cancer 2019 Feb 7. Epub 2019 Feb 7.

Department of Thoracic Surgery, The Second Hospital of Tianjin Medical University, Tianjin, China.

Background: To investigate the gene expression profile of a set of candidate genes for a better understanding of the molecular mechanism underlying the pathogenesis of thymoma with or without myasthenia gravis.

Methods: Thymoma patients and thymoma patients with myasthenia gravis were analyzed using microarray profiling to identify significant changes in gene expression of autoimmune regulator pathway genes including AIRE, IL-7R, CHRNA3, SYMD1, THRA, and CAV3.

Results: Across all of our samples, we found that 1484 mRNAs were upregulated and 770 were downregulated in thymoma patients compared with thymoma with myasthenia gravis patients. Read More

Gen Thorac Cardiovasc Surg 2019 Feb 6. Epub 2019 Feb 6.

Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Background: Although multidisciplinary treatment is recommended for patients with advanced stage and recurrent thymoma, a detailed treatment strategy remains controversial. We have performed a multimodality therapy of induction chemotherapy (CAMP therapy: cisplatin, doxorubicin, and methylprednisolone) combined with surgery for those patients. We now conducted a retrospective study for investigating the results of this multimodality therapy for thymoma patients with pleural dissemination. Read More

Eur J Neurol 2019 Feb 3. Epub 2019 Feb 3.

Neuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy.

Background: Acquired neuromyotonia can occur in patients with thymoma, alone or in association with myasthenia gravis (MG), but the clinic-prognostic significance of such comorbidity is largely unknown. We investigated clinic-pathologic features, along with the occurrence of neuromyotonia as predictors of tumor recurrence in patients with thymoma-associated myasthenia.

Methods: We retrospectively studied 268 patients with thymomatous MG. Read More

Indian J Nucl Med 2019 Jan-Mar;34(1):45-47

Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy.

An 80-year-old male with a previous history of thymoma and kidney cancer underwent a F fluorodeoxyglucose (FDG) positron emission tomography (PET)/contrast-enhanced computed tomography (CT) scan: two pulmonary nodules were discovered, both characterized by an increased glucose uptake. Of them, only one showed mild contrast enhancement. Both nodules were surgically resected: the first nodule was a benign meningioma and the second one was a malignant meningioma. Read More

Anticancer Res 2019 Feb;39(2):533-539

Department of Obstetrics and Gynaecology, Whipps Cross University Hospital, Barts Health NHS Trust, London, U.K.

Endometrial cancer (EC) is the most common cancer of the female genital tract, resulting annually in 76,000 related deaths worldwide. EC originates either from oestrogen-related proliferative endometrium (type I, endometrioid), or from atrophic endometrium (type II, non-endometrioid). Each type of EC is characterized by different molecular profile alterations. Read More

eNeurologicalSci 2019 Mar 7;14:72-73. Epub 2019 Jan 7.

Department of Neurology, Tsuchiura Kyodo General Hospital, 4-1-1 Otsuno, Tsuchiura-shi, Ibaraki, 300-0028, Japan.

Toxicol Pathol 2019 Jan 30:192623318822301. Epub 2019 Jan 30.

1 Pathology Department, Nonclinical Research Center, LSI Medience Corporation, Kamisu-shi, Ibaraki, Japan.

Thymomas occur prevalently in aged Wistar Hannover (WH) rats, along with hyperplastic lesions that cannot be categorized as thymomas. We compared the histological features of hyperplastic lesions and thymomas in WH rats, the incidences of these lesions, and the relationship of these lesions to the degree of thymic involution and also compared these lesions with those of Sprague Dawley (SD) rats in 4-, 13-, 26-, and 104-week studies. There were no morphological differences between hyperplastic cells and benign tumor cells in thymomas. Read More

Neurol Neuroimmunol Neuroinflamm 2019 Mar 24;6(2):e535. Epub 2018 Dec 24.

Department of Neurology (N.U., K.T., C.I., A.U., A.K., T.T., J.S.), Graduate School of Medicine, University of Tokyo; Division of Neurology (M.K., K.K.), Department of Internal Medicine, National Defense Medical College, Saitama; Division of Neurology (Y. Shiio), Tokyo Teishin Hospital; Department of Neurology (Y. Sakurai), Mitsui Memorial Hospital; Department of Neurology (Y.H.), Teikyo University School of Medicine; and Department of Neurology (K.Y., S.N.-E.), Fukushima Medical University, Japan.

Objective: To provide evidence that idiopathic inflammatory myopathy (IM) with myasthenia gravis (MG) frequently shows thymoma association and polymyositis (PM) pathology and shares clinicopathologic characteristics with IM induced by immune checkpoint inhibitors (ICIs).

Methods: We analyzed the clinicopathologic features of 10 patients with idiopathic IM and MG identified in 970 consecutive patients with biopsy-proven IM.

Results: Seven patients (70%) had thymoma. Read More

Front Neurol 2018 15;9:1173. Epub 2019 Jan 15.

Department of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.

The ability to distinguish between a normal thymus, thymic hyperplasia, and thymoma should aid in clinical management and decision making for patients with myasthenia gravis (MG). We sought to determine the accuracy of routine radiological examinations in predicting thymic pathology. We retrospectively analyzed the records of patients with MG who had undergone thymectomy from the Second Affiliated Hospital of Zhengzhou University. Read More

Acta Neurol Scand 2019 Jan 28. Epub 2019 Jan 28.

Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.

Background: Data on antibody profile in myasthenia gravis (MG) from India are limited.

Objectives: To investigate antibody profile in patients with MG and their clinical correlates.

Patients And Methods: Patients of MG (n = 85, M:F::1. Read More

Clin Immunol 2019 Jan 25;200:39-42. Epub 2019 Jan 25.

Dept. of Immunology, Erasmus MC, University Medical Center Rotterdam, the Netherlands; Dept. of Pediatrics, Laboratory for Immunology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

Good syndrome is an immunodeficiency presenting with thymoma, hypogammaglobulinemia and almost absent B cells. To investigate the origin of the B-cell lymphopenia in these patients, we studied B cell differentiation in the bone marrow of Good syndrome patients. We found very low numbers of precursor B cells in bone marrow of Good syndrome patients and a differentiation arrest after the pro-B-cell stage; this is different from other agammaglobulinemia patients with a defect in pre B-cell receptor signaling. Read More

Ther Drug Monit 2019 Jan 25. Epub 2019 Jan 25.

Department of Medical Microbiology and Infection Control, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

This paper presents three cases of immunocompromised patients for whom therapeutic drug monitoring (TDM) of ganciclovir in combination with cytomegalovirus (CMV) viral load measurement was used to guide treatment. The first patient is diagnosed with Thymoma A, the second is a heart transplant recipient and the third is an HIV positive patient. These patients were all diagnosed with CMV and treated with ganciclovir. Read More

J Neuroimmunol 2019 Feb 11;327:10-14. Epub 2019 Jan 11.

Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, Germany; Department of Neurology, Charité - Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Germany.

In Myasthenia Gravis (MG) thymic pathologies are often present and thymectomy is used as treatment. By flow cytometry we elucidated alterations of naïve CD4 T cell homeostasis in MG patients and patients with thymoma. MG patients showed increased absolute numbers of CD31naïve CD4 T cells. Read More

Int J Surg 2019 Jan 21. Epub 2019 Jan 21.

Department of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, 210009, China. Electronic address:

Background: Thymectomy is increasingly being performed via minimally invasive approaches. The present study aimed to assess the safety and feasibility of the subxiphoid approach to video-assisted thoracic surgery (VATS) compared with the lateral intercostal approach VATS.

Methods: Patients who underwent VATS thymectomy via subxiphoid and lateral intercostal approaches in our hospital between 2015 and 2018 wereretrospectively analyzed. Read More

Phys Med 2019 Jan 17;57:215-220. Epub 2019 Jan 17.

Ospedale Santa Chiara di Trento, Centro di Protonterapia, Trento, Italy; TIFPA, Trento Institute for Fundamentals Physics Applications, Trento, Italy.

Purpose: To report on the implementation, validation and results of the first two proton therapy PBS treatments of limited amplitudes moving targets performed at our center.

Methods And Materials: A real time optical tracking system was used to monitor the patient surface during the CT scan and treatment. This system is also able to trigger the beam during the treatment. Read More

J Dermatol 2019 Jan 18. Epub 2019 Jan 18.

Department of Comprehensive Cancer Therapy, Shinshu University School of Medicine, Matsumoto, Japan.

Cureus 2018 Nov 13;10(11):e3581. Epub 2018 Nov 13.

Cardiac/thoracic/vascular Surgery, London Health Sciences Centre, London, CAN.

We report a young adult with thymoma-associated myasthenia gravis (MG) who, following thymectomy, developed paraneoplastic limbic encephalitis (LE) and systemic lupus erythematosus (SLE). Although thymomas commonly co-occur with MG, LE is an uncommon autoimmune sequela. Herein, we discuss the pathophysiology of paraneoplastic LE and its management. Read More

Autophagy 2019 Feb 5:1-13. Epub 2019 Feb 5.

b Department of Molecular Cell Biology, Single Cell Network Research Center , Sungkyunkwan University School of Medicine , Suwon , South Korea.

Protein arginine methyltransferases (PRMTs) have emerged as important regulators of skeletal muscle metabolism and regeneration. However, the direct roles of the various PRMTs during skeletal muscle remodeling remain unclear. Using skeletal muscle-specific prmt1 knockout mice, we examined the function and downstream targets of PRMT1 in muscle homeostasis. Read More

Medicine (Baltimore) 2019 Jan;98(3):e14198

Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences.

Rationale: Metastatic thymic carcinoma in the spine is a rare disease with no standard curative managements yet. The objective of this study is to report a very rare case of spinal metastases of thymic carcinoma successfully operated by combination of instrumentation and cement augmentation together with adjuvant treatment. The management of these unique cases has yet to be well-documented. Read More

FEBS Open Bio 2019 Jan 3;9(1):101-113. Epub 2018 Dec 3.

Research Support Center Dokkyo Medical University Tochigi Japan.

Exercise generates heat, blood flow, and metabolic changes, thereby inducing hypertrophy of skeletal muscle cells. However, the mechanism by which heat incudes hypertrophy in response to heat is not well known. Here, we hypothesized that heat would induce differentiation of myoblast cells. Read More

Surg Neurol Int 2018 13;9:253. Epub 2018 Dec 13.

Department of Neurophysiology, Puerta de Hierro University Hospital, Madrid, Spain.

Background: Spinal dissemination of thymic tumors is rare but should be considered in the differential diagnosis of thoracic dumbbell-shaped lesions and/or vertebral tumors, irrespective of the time since the initial diagnosis.

Case Description: A 63-year-old man, with a history of invasive type AB thymoma treated 21 years ago, newly presented to the hospital with a dumbbell-shaped T8-T9 lesion compressing the spinal cord. A review of the literature showed only 16 previous cases of thymic tumors with thoracic spine involvement. Read More

Thorac Cancer 2019 Jan 9. Epub 2019 Jan 9.

Department of Pathology, GROW-School for Oncology & Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands.

Background: The etiology of thymic epithelial tumors is unknown. Murine polyomavirus strain PTA has been shown to induce thymomas in mice. Recently, using diverse molecular techniques, we reported the presence of human polyomavirus 7 (HPyV7) in thymic epithelial tumors. Read More

Open Access Maced J Med Sci 2018 Dec 14;6(12):2373-2375. Epub 2018 Dec 14.

Hematology and Pediatric Oncology Center, Hospital 20 Aout Pediatric, Casablanca, Morocco.

Background: Concomitant thymoma and T- lymphoblastic/leukaemia lymphoma is possible. Secondary thymoma after treatment for T-lymphoblastic/leukaemia lymphoma was also occasionally reported, although this is quite rare.

Case Report: We report a case of 44-year-old women with secondary thymoma after chemotherapy treatment for T Acute Lymphoblastic leukaemia/lymphoma. Read More

Dtsch Arztebl Int 2018 11;115(46):784

J Clin Neurosci 2019 Jan 24;59:179-184. Epub 2018 Oct 24.

Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, China; Department of Neurology, Jing'an District Centre Hospital of Shanghai, China. Electronic address:

To compare HLA typing between juvenile- and adult-onset myasthenia gravis (MG), we enrolled 101 children (age ≤12 years) and 168 adults (age ≥20 years) with MG. We excluded patients with histories of thymoma, thyroid disease, or other autoimmune disease. We selected 41 seronegative juvenile-onset patients with ocular symptoms only, and 41 seropositive adult-onset patients with generalized symptoms. Read More

Kyobu Geka 2018 12;71(13):1136-1139

Department of Thoracic Surgery, Japanese Red Cross Kobe Hospital, Kobe, Japan.

A 76-year-old man was referred to our division because of an abnormal shadow on chest computed tomography (CT). CT revealed a 20 mm nodule in the anterior mediastinum. Non-ivasive thymoma was suspected and thymomectomy and resection of right thymus was performed. Read More

Ann Thorac Surg 2018 Dec 18. Epub 2018 Dec 18.

Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine.

Background: Patients with thymomas are at high risk of developing extrathymic malignancies. We investigated the impact of extrathymic malignancies on the prognosis of patients with thymoma who underwent surgery and the risk factors for postoperative extrathymic malignancies.

Methods: A multicenter retrospective review of 252 patients who underwent surgical resection of thymomas from January 1977 to March 2016 was conducted. Read More

Neurol Res 2018 Dec 21:1-7. Epub 2018 Dec 21.

a Department of Neuromicrobiology , National Institute of Mental Health and Neurosciences , Bangalore , India.

Objective: To evaluate transcervical and transsternal thymectomy benefits in large myasthenia gravis (MG) cohort.

Method: We retrospectively evaluated MG patients (n = 184) who had undergone thymectomy between 2004 and 2015 at National Institute of Mental Health and Neurosciences, Bangalore (India). Myasthenia gravis foundation of America guidelines were followed to assess clinical outcome. Read More

Medicine (Baltimore) 2018 Dec;97(51):e13796

Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences.

Rationale: Malignant thymoma in the spine is a rare disease without standard curative managements so far. The objective of this article is to report a very rare case of recurrent malignant thymoma with sacrum metastases causing severe lumbosacral pain, which was presented with acute radiculopathy and treated with 2 operations combined with stabilization and cement augmentation. The management of these unique cases is not well-documented. Read More

Radiology 2019 Jan;290(1):264-269

From the Department of Diagnostic Imaging, San Luigi Gonzaga Hospital, University of Torino, Regione Gonzole 10, Orbassano 10043 (Torino), Italy.

History A 29-year-old woman presented with a 6-month history of progressive general fatigue, fluctuating limb weakness, and difficulty climbing stairs. She initially experienced occasional episodes of transient diplopia that developed while reading in the evening. She subsequently started to experience dry eyes and mouth, difficulty chewing, and mild dysphagia that worsened throughout the day. Read More

Intern Med 2018 Dec 18. Epub 2018 Dec 18.

Department of Neurology, Brain Science Centre, Sapporo City General Hospital, Japan.

To explore non-motor comorbidities of myasthenia gravis (MG), we present two cases of thymoma-associated MG patients. Alopecia, pure red cell aplasia, and thymoma- associated multiorgan autoimmunity were observed in Case 1, and alopecia, thrombocytopenia, hypogammaglobulinemia and nephrotic syndrome were observed in Case 2. In both cases, autoreactive T lymphocytes inappropriately stimulated by thymus tissue may have played key roles in generating the various autoimmune-associated symptoms. Read More

FASEB J 2018 Dec 19:fj201801690R. Epub 2018 Dec 19.

Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

The age-related functional exhaustion limits potential efficacy of mesenchymal stem cell (MSC) in treating cardiovascular disease. Therefore, rejuvenation of aged MSC in the elderly population is of great interest. We have previously reported that Erb-B2 receptor tyrosine kinase 4 ( ERBB4) plays a critical role in regulating MSC survival under hypoxia. Read More

J Cell Physiol 2018 Nov 22. Epub 2018 Nov 22.

Department of Biomedical, Metabolic, and Neural Sciences, Section of Morphology, Signal Transduction Unit, University of Modena and Reggio Emilia, Modena, Italy.

Clusterin (CLU) is a chaperone-like protein with multiple functions. sCLU is frequently upregulated in prostate tumor cells after chemo- or radiotherapy and after surgical or pharmacological castration. Moreover, CLU has been documented to modulate the cellular homolog of murine thymoma virus akt8 oncogene (AKT) activity. Read More

Cancer 2019 Mar 18;125(5):807-817. Epub 2018 Dec 18.

Center for Precision Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Background: The management of most solid tumors of the anterior mediastinum involves complete resection. Because of their location near mediastinal structures, wide resection is not possible; therefore, surgeons must use subjective visual and tactile cues to determine disease extent. This clinical trial explored intraoperative near-infrared (NIR) imaging as an approach to improving tumor delineation during mediastinal tumor resection. Read More

BMC Cancer 2018 Dec 13;18(1):1249. Epub 2018 Dec 13.

Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, Japan.

Background: Thymomas are typically slow-growing tumors and AB type thymomas are considered no/low risk tumors with a better prognosis. Extra-thoracic metastases are extremely rare. To the best of our knowledge, no patient with an isolated splenic metastasis from a thymoma has been reported. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13563

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Rationale: An association between inflammatory myopathy and malignancy has been recognized particularly in patients positive for anti-transcription intermediary factor 1γ (TIF1γ) antibody. We report a case of anti-TIF1γ antibody positive dermatomyositis (DM) associated with thymic carcinoma which radiographically mimicked benign tumor.

Patient Concerns: A 72-year-old man presented typical characteristic cutaneous manifestations and proximal muscle weakness with elevated levels of myogenic enzymes. Read More

J Cancer Res Clin Oncol 2019 Mar 12;145(3):625-636. Epub 2018 Dec 12.

Department of Science, The Wheatley School, Old Westbury, NY, USA.

Purpose: Mutations in the tumor suppressor gene TP53 are associated with a variety of cancers. Therefore, it is important to know the occurrence and prognostic effects of TP53 mutations in certain cancers.

Methods: Over 29,000 cases from the April 2016 release of the International Agency for Research on Cancer (IARC) TP53 Database were analyzed to determine the distribution of germline and somatic mutations in the TP53 gene. Read More

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology, The university of Texas, M D Anderson Cancer Center, Houston, TX. Electronic address:

Eight cases of primary thymic epithelial neoplasms corresponding to seven thymomas and one thymic carcinoma with sebaceous differentiation are presented. The patients are five men and three women between the ages of 45 and 63years (average: 54years) who presented with non-specific symptomatology related to their mediastinal mass. All patients underwent complete surgical resection of the mediastinal mass. Read More