11,260 results match your criteria Thymoma


CT imaging-based machine learning model: a potential modality for predicting low-risk and high-risk groups of thymoma: "Impact of surgical modality choice".

World J Surg Oncol 2021 May 11;19(1):147. Epub 2021 May 11.

Department of Radiology, Ankara University Faculty of Medicine, 06100, Sıhhiye, Ankara, Turkey.

Introduction: Radiomics methods are used to analyze various medical images, including computed tomography (CT), magnetic resonance, and positron emission tomography to provide information regarding the diagnosis, patient outcome, tumor phenotype, and the gene-protein signatures of various diseases. In low-risk group, complete surgical resection is typically sufficient, whereas in high-risk thymoma, adjuvant therapy is usually required. Therefore, it is important to distinguish between both. Read More

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Invasive thymoma - Which patients benefit from post-operative radiotherapy?

Asian Cardiovasc Thorac Ann 2021 May 11:2184923211017094. Epub 2021 May 11.

Department of Thoracic Surgery, Nuvance Health System, Connecticut & New York, USA.

Background: The aim of this study is to identify patients with thymoma who should receive post-operative radiotherapy.

Methods: The Surveillance, Epidemiology, and End Results database was queried for stage IIB-IV thymoma patients diagnosed during 1988-2015. We analyzed the prognostic implications of various clinical-pathological factors by comparing the outcomes of those who received surgery with and without post-operative radiotherapy. Read More

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Sema4D correlates with tumour immune infiltration and is a prognostic biomarker in bladder cancer, renal clear cell carcinoma, melanoma and thymoma.

Autoimmunity 2021 May 11:1-9. Epub 2021 May 11.

Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.

Sema4D, a member of the immune semaphorin family, plays crucial roles in the immune regulation, bone resorption and nervous system. It is also involved in angiogenesis and tumour progression. However, systemic studies on the correlation between Sema4D expression and the immune infiltration or clinical outcomes in tumours are still limited. Read More

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Imaging Features of Primary Immunodeficiency Disorders.

Radiol Cardiothorac Imaging 2021 Apr 25;3(2):e200418. Epub 2021 Mar 25.

Faculty of Medical Sciences, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras (J.A.R.); Department of Radiology, Division of Cardiopulmonary Imaging, University of Colorado School of Medicine, 12401 E 17th Ave, Aurora, CO 80045 (T.J.B., D.V.); Department of Radiology, University of Texas Health Science Center, San Antonio, Tex (C.S.R.); Department of Radiology, Weill Cornell Medicine, New York, NY (D.B.G.); and Department of Radiology, Children's Hospital Colorado, Aurora, Colo (L.P.B.).

Primary immunodeficiency disorders (PIDs), which are humoral, combined, and innate defects of the immune system, are relatively uncommon and may go undiagnosed in patients experiencing recurrent infections, resulting in increased morbidity and mortality. PIDs are clinically characterized by a broad spectrum of disorders, including repeated infections, autoimmune disorders, lymphoproliferative diseases, congenital anomalies, and increased risk of malignancy. Cardiothoracic imaging plays a crucial role in the diagnosis of PIDs owing to the high rates of repeated respiratory infections leading to bronchiectasis and other forms of chronic lung disease. Read More

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GAD1 expression and its methylation as indicators of malignant behavior in thymic epithelial tumors.

Oncol Lett 2021 Jun 21;21(6):483. Epub 2021 Apr 21.

Department of Thoracic, Endocrine Surgery and Oncology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8503, Japan.

Thymic epithelial tumors (TETs) comprise thymomas and thymic carcinoma (TC). TC has more aggressive features and a poorer prognosis than thymomas. Genetic and epigenetic alterations in thymomas and TC have been investigated in an attempt to identify novel target molecules for TC. Read More

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Examination of endobronchial ultrasound-guided transbronchial needle aspiration using a puncture needle with a side trap.

Sci Rep 2021 May 7;11(1):9789. Epub 2021 May 7.

Department of Respiratory Medicine, Yokohama Municipal Citizen's Hospital, Yokohama, Kanagawa, Japan.

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is useful for diagnosing hilar and mediastinal lymph node enlargement; however, specimens obtained are often small and inadequate for pathologic diagnosis. In June 2017, EchoTip ProCore, a puncture needle with a side trap, was launched in Japan. In this single-center prospective interventional study, 57 patients with lymph nodes, intrapulmonary tumor or pleural mass were diagnosed using EBUS-TBNA with EchoTip ProCore between June 2017 and February 2020. Read More

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Thymic Carcinoma with Multiple Paraneoplastic Disorders.

Am J Med Sci 2021 May 4. Epub 2021 May 4.

2(nd) Academic Department of Internal Medicine, Medical School, National & Kapodistrian University of Athens, Hippokration General Hospital, Athens, Greece. Electronic address:

Thymic neoplasms are rare and may run an indolent course. Among them, thymic epithelial carcinoma is exceptional as it may be presented with extensive local invasion and distant metastases. There is a wide spectrum of autoimmune/paraneoplastic syndromes associated with thymic tumors including autoimmune diseases, some of which may precede the diagnosis of thymoma. Read More

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Type A thymoma with simultaneous solitary intrapulmonary metastasis: A case report.

Thorac Cancer 2021 May 7. Epub 2021 May 7.

Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

A 79-year-old woman was referred to our facility because of an abnormal chest shadow. Chest computed tomography (CT) showed a solitary right middle lung nodule with a maximum diameter of 3 mm and anterior mediastinal nodule with a maximum diameter of 21 mm. The lung nodule was suspected of being a primary lung cancer rather than a metastatic tumor because there were no primary malignant tumors, apart from an anterior mediastinal tumor visible on diagnostic imaging, including F fluorodeoxyglucose-positron emission tomography, and a solitary lung nodule. Read More

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Pathogenesis, diagnosis and treatment of paraneoplastic neurologic syndromes.

Authors:
Franz Blaes

Expert Rev Neurother 2021 May 7. Epub 2021 May 7.

Department of Neurology, KKH Gummersbach, Wilhelm-Breckow-Allee 20, 51643 Gummersbach, Germany.

Introduction: Paraneoplastic neurological syndromes (PNS) are a rare heterogeneous group of neurological diseases associated with tumors. These syndromes are the result of a cross-reactive immune response against antigens shared by the tumor and the nervous system. The discovery of an increasing number of autoantigens and the identification of tumoral factors leading to a substantial antitumoral immune response makes this topic highly innovative. Read More

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Calcification in thymomas can predict invasiveness to surrounding organs.

Thorac Cancer 2021 May 6. Epub 2021 May 6.

Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Bioscience, University of Tokushima Graduate School, Tokushima, Japan.

Background: Thymomas are the most common type of anterior mediastinal tumors. Calcification is sometimes observed in thymomas using computed tomography (CT), and it is more frequent in invasive thymomas than in noninvasive thymomas. However, the significance of calcification in thymomas remains unknown. Read More

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Adaptive Radiation Therapy for Intact Thymoma: An Illustrative Report.

Anticancer Res 2021 May;41(5):2467-2471

Department of Radiation Oncology, Houston Methodist Hospital, Houston, TX, U.S.A.;

Background/aim: Adaptive radiation therapy (ART) is a technique capable of reducing radiation dose to normal tissue without compromising local control. For potentially resectable thymoma, induction therapy is standard of care. Because large disease volume is common in this context, ART has been suggested to reduce toxicity from induction chemoradiation. Read More

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Micronodular thymoma with lymphoid stroma: a clinicopathological study of five cases.

Pathology 2021 May 1. Epub 2021 May 1.

Department of Tissue Pathology and Diagnostic Oncology, NSW Health Pathology, Royal Prince Alfred Hospital, Sydney, NSW, Australia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia; School of Medicine, Western Sydney University, Sydney, NSW, Australia. Electronic address:

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Toxic epidermal necrolysis-like presentation of paraneoplastic pemphigus due to underlying thymoma: A clinical conundrum.

J Postgrad Med 2021 Apr-Jun;67(2):119-121

Department of Dermatology, Government Medical College and Hospital, Chandigarh, India.

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Immune-Therapy-Related Toxicity Events and Dramatic Remission After a Single Dose of Pembrolizumab Treatment in Metastatic Thymoma: A Case Report.

Front Immunol 2021 15;12:621858. Epub 2021 Apr 15.

Department of Radiation Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Immune checkpoint inhibitor therapy has become a promising option for the treatment of late-stage thymic epithelial tumors. In this manuscript, we presented a patient with metastatic thymoma administrated of anti-programmed cell death protein 1 (PD-1) antibody pembrolizumab. Although the patient underwent a rapid and dramatic response to one dose of pembrolizumab, she suffered a storm of immune-therapy related toxicity events (irAEs), including liver and kidney dysfunction, hypothyroidism and myocarditis. Read More

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A Panel of Five-lncRNA Signature as a Potential Biomarker for Predicting Survival in Gastric and Thoracic Cancers.

Front Genet 2021 13;12:666155. Epub 2021 Apr 13.

Department of Gastroenterology, Heilongjiang Provincial Hospital, Harbin, China.

Dysfunctional long non-coding RNAs (lncRNAs) have been found to have carcinogenic and/or tumor inhibitory effects in the development and progression of cancer, suggesting their potential as new independent biomarkers for cancer diagnosis and prognosis. The exploration of the relationship between lncRNAs and the overall survival (OS) of different cancers opens up new prospects for tumor diagnosis and treatment. In this study, we established a five-lncRNA signature and explored its prognostic efficiency in gastric cancer (GC) and several thoracic malignancies, including breast invasive carcinoma (BRCA), esophageal carcinoma, lung adenocarcinoma, lung squamous cell carcinoma (LUSC), and thymoma (THYM). Read More

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Goods syndrome combined with bronchiectasis: A case report and literature review.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Mar;46(3):328-332

Department of Respiratory Diseases, Second Xiangya Hospital, Central South University, Changsha 410011, China.

A patient with thymoma associated immunodeficiency syndrome (Good's syndrome) and bronchiectasis was retrospectively analyzed. Good's syndrome is a rare condition of immunodeficiency that is characterized by thymoma and hypogammaglobulinemia. It is important to bear in mind that Good's syndrome should be included in the differential diagnosis When patients repeatedly visited for bronchiectasis or infection, we should alert to their immune state and history of thymoma. Read More

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An ectopic invasive pericardial thymoma involving the great vessels.

Asian J Surg 2021 Apr 26. Epub 2021 Apr 26.

Division of Thoracic Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Electronic address:

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Renal Diseases Associated with Hematologic Malignancies and Thymoma in the Absence of Renal Monoclonal Immunoglobulin Deposits.

Diagnostics (Basel) 2021 Apr 15;11(4). Epub 2021 Apr 15.

Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Henri Mondor, Service de Néphrologie et Transplantation, Centre de Référence Maladie Rare "Syndrome Néphrotique Idiopathique", Fédération Hospitalo-Universitaire "Innovative Therapy for Immune Disorders", 94000 Créteil, France.

In addition to kidney diseases characterized by the precipitation and deposition of overproduced monoclonal immunoglobulin and kidney damage due to chemotherapy agents, a broad spectrum of renal lesions may be found in patients with hematologic malignancies. Glomerular diseases, in the form of paraneoplastic glomerulopathies and acute kidney injury with various degrees of proteinuria due to specific lymphomatous interstitial and/or glomerular infiltration, are two major renal complications observed in the lymphoid disorder setting. However, other hematologic neoplasms, including chronic lymphocytic leukemia, thymoma, myeloproliferative disorders, Castleman disease and hemophagocytic syndrome, have also been associated with the development of kidney lesions. Read More

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An Overview on Molecular Characterization of Thymic Tumors: Old and New Targets for Clinical Advances.

Pharmaceuticals (Basel) 2021 Apr 1;14(4). Epub 2021 Apr 1.

Department of Experimental, Diagnostic and Specialty Medicine, Policlinico di Sant'Orsola University Hospital, Via P. Albertoni 15, 40138 Bologna, Italy.

Thymic tumors are a group of rare mediastinal malignancies that include three different histological subtypes with completely different clinical behavior: the thymic carcinomas, the thymomas, and the rarest thymic neuroendocrine tumors. Nowadays, few therapeutic options are available for relapsed and refractory thymic tumors after a first-line platinum-based chemotherapy. In the last years, the deepening of knowledge on thymus' biological characterization has opened possibilities for new treatment options. Read More

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Mediastinal diffuse large B-cell lymphoma mimicking invasive thymoma on Ga-FAPI PET/CT.

J Nucl Cardiol 2021 Apr 28. Epub 2021 Apr 28.

Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No. 25 TaiPing St, Jiangyang District, Luzhou, 646000, Sichuan, People's Republic of China.

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LOXL1‑AS1 promotes thymoma and thymic carcinoma progression by regulating miR‑525‑5p‑.

Oncol Rep 2021 Jun 28;45(6). Epub 2021 Apr 28.

Department of Cardiothoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.

Due to the lack of specific symptoms in early thymic epithelial tumours (TETs), patients are mostly in the advanced stage at the time of presentation. The aim of the present study was to explore the mechanism by which the long noncoding RNA (lncRNA) LOXL1‑AS1 affects thymoma and thymic carcinoma progression by targeting the miR‑525‑5p‑ axis. Bioinformatics was used to analyse the process of LOXL1‑AS1 targeting miR‑525‑5p‑ and its expression characteristics in TET. Read More

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Myasthenia Gravis with Thymoma and a Rare Serological Profile-Report of a Case and Review of Literature.

Neurol India 2021 Mar-Apr;69(2):528-529

Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Thiruvananthapuram, Kerala, India.

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Determinants of Suboptimal Outcome Following Thymectomy in Myasthenia Gravis.

Neurol India 2021 Mar-Apr;69(2):419-425

Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.

Background: Response to thymectomy in myasthenia gravis (MG) is influenced by various patient-, disease-, and therapy-related factors.

Methods: Retrospective analysis of 128 patients with MG who underwent maximal thymectomy over 15 years was done to identify the determinants of suboptimal clinical outcome.

Results: Among the 128 patients, 62 (48. Read More

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[Chinese guideline for clinical diagnosis and treatment of thymic epithelial tumors (2021 Edition)].

Authors:

Zhonghua Zhong Liu Za Zhi 2021 Apr;43(4):395-404

Thymic tumor is a relatively rare type of thoracic cancer, which is pathologically-classified as thymic epithelial tumors by World Health Organization (WHO), including thymoma and thymic carcinoma. The incidence of thymic epithelial tumors in China is about 4.09 per million, which is slightly higher than that in European and American countries. Read More

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Expression of cancer testis antigens in thymic epithelial tumors.

Pathol Int 2021 Apr 26. Epub 2021 Apr 26.

Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.

Cancer testis antigens (CTAs) are detected in cancer cells but not in healthy normal tissues, with the exception of gametogenic tissues. However, to our knowledge, expression of the antigens in thymic epithelial tumors has not been examined yet. We examined the immunohistochemical expression of five CTAs (MAGE-A, NY-ESO-1, MAGE-C1, SAGE and GAGE7) in 192 cases of thymic epithelial tumor. Read More

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Paraneoplastic Neurological Syndromes and Beyond Emerging With the Introduction of Immune Checkpoint Inhibitor Cancer Immunotherapy.

Front Neurol 2021 9;12:642800. Epub 2021 Apr 9.

Departments of Neurology and Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, United States.

Paraneoplastic neurological syndromes are more commonly seen with malignancies such as small cell lung cancer, thymoma, gynecological malignancies, and breast cancer as well as seminoma. With the introduction of immune checkpoint inhibitor (ICI) cancer immunotherapy we see an increase of autoimmune neurological complications in patients with malignancies not traditionally associated with paraneoplastic neurological syndromes, such as melanoma and renal cell carcinoma. Immune checkpoint inhibitors enhance antitumor immune responses resulting often in immune-related adverse effects that can affect any organ, including the central and peripheral nervous system, neuromuscular junction and muscle. Read More

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Respiratory Disorders in Rabbits.

Authors:
Vladimír Jekl

Vet Clin North Am Exot Anim Pract 2021 May;24(2):459-482

Jekl & Hauptman Veterinary Clinic, Focused on Exotic Companion Mammal Care, Mojmirovo namesti 3105/6a, Brno 61200, Czech Republic; Department of Pharmacology and Pharmacy, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Brno 61242, Czech Republic. Electronic address:

Respiratory disorders are very common in rabbits. Rabbits are obligate nasal breathers, so "simple" rhinitis can cause severe respiratory distress and patient collapse. Causes of dyspnea could be of primary origin or secondary, whereby diseases primarily affecting other organs can result in respiratory embarrassment even if the respiratory system is healthy (eg, anemia, cardiac disease). Read More

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Recurrent neutropenia and chronic diarrhea following thymectomy: the good, the bad, and the ugly.

J Community Hosp Intern Med Perspect 2021 Mar 23;11(2):263-265. Epub 2021 Mar 23.

Department of Internal Medicine, SSM St. Mary's Hospital, St. Louis, MO, USA.

Good syndrome (GS) is a rare paraneoplastic syndrome seen before or after diagnosis of thymoma, and its treatment, and is characterized by hypogammaglobulinemia. Rarely, pure white cell aplasia (PWCA) can also be seen which can present as recurrent neutropenia. We describe a 64-year-old man with recurrent sinus infections and previous thymectomy for stage 1 type B2 thymoma presenting with chronic diarrhea and recurrent neutropenia necessitating serial hospitalizations despite repeated antimicrobial treatment. Read More

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Oncological resection, myasthenia gravis and staging as prognostic factors in thymic tumours: a Chilean case series.

Ecancermedicalscience 2021 9;15:1201. Epub 2021 Mar 9.

Department of Hematology and Oncology, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Diagonal Paraguay 319, Santiago 8330032, Chile.

Background: Thymic epithelial tumours are rare and highly heterogeneous. Reports from the United States suggest an overall incidence of 0.15 per 100,000/year. Read More

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