10,324 results match your criteria Thymoma


Thymic epithelial neoplasms with sebaceous differentiation: a clinicopathological and Immunohistochemical study of 8 cases.

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology, The university of Texas, M D Anderson Cancer Center, Houston, TX. Electronic address:

Eight cases of primary thymic epithelial neoplasms corresponding to seven thymomas and one thymic carcinoma with sebaceous differentiation are presented. The patients are five men and three women between the ages of 45 and 63years (average: 54years) who presented with non-specific symptomatology related to their mediastinal mass. All patients underwent complete surgical resection of the mediastinal mass. Read More

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December 2018

Complete remission of pure white cell aplasia associated with thymoma after thymectomy and cyclosporine administration.

Int J Hematol 2018 Dec 9. Epub 2018 Dec 9.

Department of Haematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.

We present the case of a 63-year-old male with pure white cell aplasia (PWCA), a rare complication of thymoma, who was successfully treated with cyclosporine A (CyA) and thymectomy. The patient presented with high fever and agranulocytosis. Complete blood count revealed a white blood cell count of 0. Read More

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December 2018

Spontaneous rupture of thymoma.

Respir Med Case Rep 2019 23;26:56-58. Epub 2018 Nov 23.

Saint Francis Hospital, Evanston, IL, United States.

We report a case of patient who presented to the hospital due to shoulder pain and was later diagnosed with ruptured thymoma. Shortly after being admitted to the hospital for the work up patient developed respiratory distress and underwent emergent endotracheal intubation. CT scan of the chest showed anterior mediastinal mass with associated right sided hemothorax. Read More

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November 2018

Systemic treatments for thymoma and thymic carcinoma: A systematic review.

Lung Cancer 2018 Dec 18;126:25-31. Epub 2018 Oct 18.

Institut du Thorax Curie Montsouris, Institut Curie, Paris, France.

Thymic tumours are rare diseases that for most of the cases are cured with surgery and eventually adjuvant radiotherapy. However, about 30% of patients present with advanced stage or relapsing tumours, which require administration of chemotherapy. While cisplatin-adriamycin-cyclophosphamide combination is regularly prescribed, other drugs have been assessed in the literature. Read More

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December 2018

Porous diaphragm syndrome with recurrent thymoma.

Respirol Case Rep 2019 Feb 28;7(2):e00391. Epub 2018 Nov 28.

Department of Medical Oncology Izumi City General Hospital Izumi Japan.

Porous diaphragm syndrome describes a defect in the diaphragm in which substances pass from the peritoneal cavity to the pleural space. Defects may be congenital or acquired. Acquired defects are caused by the thinning and eventual splitting of collagen fibres in the tendinous part of the diaphragm. Read More

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February 2019

Value of CT spectral imaging in the differential diagnosis of thymoma and mediastinal lymphoma.

Br J Radiol 2018 Dec 3:20180598. Epub 2018 Dec 3.

1 Department of Radiology, Lanzhou University Second Hospital , Lanzhou , PR China.

Objective:: To investigate the imaging characteristics of thymoma and mediastinal lymphoma using spectral CT and evaluate whether the quantitative information can improve the differential diagnosis of these diseases.

Methods:: This retrospective study was approved by the institutional review board, and written informed consent was obtained from all patients. Overall, 39 patients with mediastinal tumors (24 thymomas and 15 mediastinal lymphomas) were examined with CT spectral imaging during the arterial phase (AP) and venous phase (VP). Read More

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December 2018

Volumetric analysis of the thymic epithelial tumors: correlation of tumor volume with the WHO classification and Masaoka staging.

J Thorac Dis 2018 Oct;10(10):5822-5832

Department of Radiology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Background: The purpose of our study was to investigate the correlation between tumor volume (TV) and each subtype of thymic epithelial tumors (TETs) based on the World Health Organization (WHO) classification and Masaoka staging.

Methods: Sixty-one consecutive patients (45 thymomas and 16 thymic carcinomas) were studied. All were classified according to Masaoka staging: 31 non-invasive TETs (stage I) and 30 invasive TETs (8 stage II, 11 stage III, 3 stage IVa, and 8 stage IVb). Read More

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October 2018

Gankyrin Contributes to Tumorigenesis and Chemoresistance in Sporadic Colorectal Cancer.

Digestion 2018 Dec 4:1-9. Epub 2018 Dec 4.

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.

Background: Although Gankyrin is overexpressed in many malignancies, the role of Gankyrin for tumorigenesis and chemoresistance remains to be elucidated in sporadic colorectal cancer (CRC).

Aims: We investigate whether Gankyrin affects Adenomatous polyposis coli (Apc) inactivation-induced tumorigenesis and therapeutic response to anti-angiogenic agents.

Methods: Epithelial cell-specific APC and/or Gankyrin-deficient mice were used. Read More

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December 2018
1 Read

Optimization of Second Window Indocyanine Green for Intraoperative Near-Infrared Imaging of Thoracic Malignancy.

J Am Coll Surg 2018 Nov 21. Epub 2018 Nov 21.

Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

Background: Near-infrared (NIR) imaging using the second time window of indocyanine green (ICG) allows localization of pulmonary, pleural, and mediastinal malignancies during surgery. Based on empirical evidence, we hypothesized that different histological tumor types fluoresce optimally at different ICG doses.

Study Design: Patients with thoracic tumors biopsy-proven or suspicious for malignancy were enrolled in an NIR imaging clinical trial. Read More

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November 2018
2 Reads

Immunoglobulin G4 related disease association with an isolated anterior mediastinal tumor.

Ann Thorac Surg 2018 Nov 21. Epub 2018 Nov 21.

Department of General Thoracic Surgery, Maebashi Red Cross Hospital, 389-1 Asakura-cho, Maebashi, Gunma 371-0811, Japan.

We treated a patient with immunoglobulin G4-related disease (IgG4-RD) exhibiting an isolated anterior mediastinal mass with high 2-[F]-fluoro-2-deoxy-D-glucose (FDG) accumulation, which mimicked thymoma. The 71-year-old male who had a 47 mm anterior mediastinal mass shadow, was referred to our department. As positron emission tomography(PET) revealed the mass to have a high level of FDG accumulation, we diagnosed it as suspected thymoma; thoracoscopic resection of the tumor was then performed. Read More

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November 2018
1 Read

Distinguishing thymoma from T-lymphoblastic leukaemia/lymphoma: a case-based evaluation.

J Clin Pathol 2018 Nov 22. Epub 2018 Nov 22.

Department of Leukemia, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA

T-lymphoblastic lymphoma and thymoma are distinct primary mediastinal neoplasms that can have similar clinical presentations and overlapping histological features. Microscopic distinction is occasionally difficult because the immature lymphocytes associated with thymoma may resemble T-lymphoblastic leukaemia/lymphoma cells, morphologically and immunohistochemically. An accurate diagnosis assumes particular importance since the treatment approaches for these two entities differ considerably. Read More

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November 2018
2 Reads

Percutaneous Irreversible Electroporation (IRE) of Hepatic Malignancy: A Bi-institutional Analysis of Safety and Outcomes.

Cardiovasc Intervent Radiol 2018 Nov 21. Epub 2018 Nov 21.

Department of Interventional Radiology, Freeman Hospital, Newcastle upon Tyne, NE7 7DN, UK.

Aim: Irreversible electroporation (IRE) is a non-thermal ablative option in patients unsuitable for standard thermal ablation, due to its potential to preserve collagenous structures (vessels and ducts) and a reduced susceptibility to heat sink effects. In this series from two large tertiary referral hepatobiliary centres, we aim to assess the safety/outcomes of hepatic IRE.

Materials And Methods: Bi-institutional retrospective, longitudinal follow-up series of IRE for primary hepatic malignancy; [hepatocellular carcinoma (n = 20), cholangiocarcinoma (n = 3)] and secondary metastatic disease; colorectal (n = 28), neuroendocrine (n = 1), pancreatic (n = 1), breast (n = 1), gastrointestinal stromal tumour (GIST, n = 1) and malignant thymoma (n = 1). Read More

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November 2018
3 Reads

Metastatic thymic carcinoid responds to chemoradiation and octreotide: A case report.

Medicine (Baltimore) 2018 Nov;97(47):e13286

Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Rationale: Thymic carcinoids are a rare type of malignant neuroendocrine tumors which have a poor prognosis due to their distant metastasis, invasive behaviour, and postoperative recurrence. Surgical resection is still the fundamental mode for treating thymic carcinoids. Here, we report the rapid shrinkage of an atypical thymic carcinoid with multiple metastases following chemoradiation plus octreotide as a first-line therapy PATIENT CONCERNS:: A 39-year-old Chinese man presented with chest tightness, dyspnea with a history of lumbago and untreated malignant thymoma. Read More

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November 2018
5 Reads

Isolated seizures are a common early feature of paraneoplastic anti-GABA receptor encephalitis.

J Neurol 2018 Nov 20. Epub 2018 Nov 20.

French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Neuro-Oncologie, Hôpital Neurologique Pierre Wertheimer, 59 Boulevard Pinel, 69677, Bron Cedex, France.

Objective: To report the clinical features and long-term outcome of 22 newly diagnosed paraneoplastic patients with GABA receptor antibodies (GABAR-Abs).

Methods: Retrospective clinical study of CSF-confirmed cases of GABAR-Abs encephalitis.

Results: We identified 22 patients (4 female) with GABAR-Abs, with a median age of 64 years (range 55-85). Read More

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November 2018
3 Reads

Intra-thymic bronchogenic cyst an extremely rare tumor of anterior mediastinum in adults.

J Cardiothorac Surg 2018 Nov 20;13(1):120. Epub 2018 Nov 20.

Department of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Background: Intra-thymic bronchogenic cysts are a rare entity but should be considered in the differential of all non-invasive thymic masses.

Case Presentation: We describe a 50-year-old patient who was found to have an incidental thymic mass on computer tomography of the chest. Non-invasive thymoma was suspected and a thoracoscopic thymectomy was performed. Read More

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November 2018
2 Reads
1.018 Impact Factor

Assessment of the prognostic role of neutrophil-to-lymphocyte ratio following complete resection of thymoma.

J Cardiothorac Surg 2018 Nov 19;13(1):119. Epub 2018 Nov 19.

Department of Thoracic Surgery, San Raffaele Scientific Institute, Milan, Italy.

Background: The introduction of the new TNM staging system for thymic epithelial malignancies produced a significant increase in the proportion of patients with stage I disease. The identification of new prognostic factors could help to select patients for adjuvant therapies based on their risk of recurrence. Neutrophil-to-lymphocyte ratio (NLR) has recently gained popularity as reliable prognostic biomarker in many different solid tumors. Read More

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November 2018
2 Reads

L-Type Amino Acid Transporter 1 Immunoreactivity as a Possible Diagnostic and Prognostic Marker of Thymic Carcinoma.

Tohoku J Exp Med 2018 11;246(3):167-174

Department of General Thoracic Surgery, Dokkyo Medical University.

L-type amino acid transporter 1 (LAT1) functions to transport large neutral amino acids, such as leucine, isoleucine, valine, phenylalanine, tyrosine, tryptophan, methionine, and histidine. These amino acids are essential for cell growth and proliferation. Many studies have demonstrated LAT1 expression in various types of cancer, and its high expression level was associated with poor prognosis. Read More

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November 2018
3 Reads

Extended pleurectomy decortication for thymoma with pleural dissemination.

Gen Thorac Cardiovasc Surg 2018 Nov 17. Epub 2018 Nov 17.

Second Department of Surgery (Chest Surgery), University of Occupational and Environmental Health, Iseigaoka 1-1, Kitakyusyu, 807-8555, Japan.

Complete resection is the mainstay of treatment for thymoma. Even for advanced-stage thymoma with pleural dissemination, complete resection with extrapleural pneumonectomy may provide a favorable prognosis. Pleurectomy decortication, a lung-sparing surgery, has been preferably employed in recent years as an alternative surgical procedure for malignant pleural mesothelioma. Read More

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November 2018
4 Reads

Resected thymic large cell neuroendocrine carcinoma: report of a case.

Surg Case Rep 2018 Nov 16;4(1):133. Epub 2018 Nov 16.

Department of Surgery, Nippon Telegraph and Telephone East Corporation Sapporo Medical Center, South 1, West 15, Chuo-ku, Sapporo, Hokkaido, 060-0061, Japan.

Background: Thymic large cell neuroendocrine carcinoma (LCNEC) is extremely rare. The detailed clinical features of thymic LNCECs remain unknown.

Case Presentation: A 90-year-old man with a history of diabetes mellitus, chronic renal failure, and an abdominal aortic aneurysm underwent computed tomography for follow-up, which showed an anterior mediastinal tumor, measuring 31 mm × 28 mm in diameter. Read More

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November 2018
5 Reads

Survival outcomes after minimally invasive thymectomy for early-stage thymic carcinoma.

Surg Today 2018 Nov 14. Epub 2018 Nov 14.

Department of Thoracic Surgery, Kyoto University Hospital, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

Minimally invasive surgery (MIS) has occasionally been used for selected patients with thymoma, but there is little information on the MIS approach for thymic carcinoma. The aim of this study was to evaluate survival outcomes after MIS for early-stage (Masaoka stage I-II) thymic carcinoma and thymic neuroendocrine carcinoma. A retrospective chart review of the cases recorded in our multi-institutional database was performed to identify patients who underwent resection for thymic carcinoma between 1995 and 2017. Read More

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November 2018
2 Reads

Different pattern of PD-L1, IDO, and FOXP3 Tregs expression with survival in thymoma and thymic carcinoma.

Lung Cancer 2018 Nov 7;125:35-42. Epub 2018 Sep 7.

Division of Thoracic Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Division of Trauma and Acute Care Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Objectives: The expression of immune checkpoint ligand PD-L1 has been reported in various tumors. The expression of IDO and FOXP3 Tregs are considered to be associated with tumor-induced tolerance and poor outcome. Their prognostic role in surgically treated thymoma and thymic carcinoma, however, has not been investigated. Read More

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November 2018
2 Reads
3.960 Impact Factor

Efficacy and toxicities of gemcitabine and cisplatin combined with endostar in advanced thymoma and thymic carcinoma.

Thorac Cancer 2018 Nov 9. Epub 2018 Nov 9.

Department of Thoracic Oncology II, Peking University Cancer Hospital & Institute, Beijing, China.

Background: Thymoma and thymic carcinoma are rare thymic epithelial tumors. We investigated the efficacy of first-line gemcitabine and cisplatin (GP) chemotherapy versus gemcitabine and cisplatin chemotherapy combined with the anti-angiogenic drug endostar (GP + E) in advanced thymoma and thymic carcinoma.

Methods: The records of 45 patients with invasive metastatic thymomas or thymic carcinomas treated with GP as first-line therapy between August 2008 and July 2017 at the Department of Respiratory Medicine, Peking University Cancer Hospital and Institute were retrospectively reviewed. Read More

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November 2018
11 Reads

Pure Red Cell Aplasia Associated with Thymolipoma: Complete Anaemia Resolution following Thymectomy.

Case Rep Hematol 2018 9;2018:8627145. Epub 2018 Oct 9.

Haematology Department, Haematology Staff Specialist, John Hunter Hospital, Lookout Rd., New Lambton Heights, NSW 2305, Australia.

Pure red cell aplasia is an uncommon cause of anaemia rarely associated with thymoma. A combination of immunosuppressive therapy and thymectomy offers a potential cure. Thymectomy alone rarely results in anaemia resolution. Read More

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October 2018
1 Read

Predictive score for oral corticosteroid-induced initial worsening of seropositive generalized myasthenia gravis.

J Neurol Sci 2018 Oct 19;396:8-11. Epub 2018 Oct 19.

Department of Neurology, Graduate School of Medicine, Chiba University, Japan.

Background: Initial worsening of symptoms after the start of corticosteroid administration is a major concern in the treatment of myasthenia gravis (MG). However, the risk factors or specific patient backgrounds related to this issue have not been fully understood. We aimed to determine the risk factors and developed a scoring system for predicting initial worsening in generalized MG. Read More

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October 2018
3 Reads

Cytotoxic action of acetate on tumor cells of thymic origin: Role of MCT-1, pH homeostasis and altered cell survival regulation.

Biochimie 2018 Nov 1;157:1-9. Epub 2018 Nov 1.

School of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India. Electronic address:

Neoplastic cells display altered biosynthetic and bioenergetic machinery to support cell survival. Therefore, cancer cells optimally utilize all available fuel resources to pump their highly upregulated metabolic pathways. While glucose is the main carbon source, transformed cells also utilize other molecules, which can be utilized in metabolic pathways, designated as alternative fuels. Read More

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November 2018
2 Reads

Prolonged Treatment of Eosinophilic Erythema Annulare with Chloroquine.

Acta Dermatovenerol Croat 2018 Oct;26(3):262-263

Assoc. Prof. Suzana Ljubojević Hadžavdić, MD, PhD, Department of Dermatology and Venereology University Hospital Center Zagreb School of Medicine University of Zagreb, Šalata 4, 10000 Zagreb, Croatia;

Dear Editor,Eosinophilic annular erythema (EAE) is a rare figurate dermatitis of unknown etiology with prominent tissue eosinophilia. A 59-year-old male patient presented with a one-month history of itchy, polycyclic, annular, and partially serpiginous lesions involving the back, the gluteal region, and the extremities (Figure 1, a, b). There was no medical history of drug intake. Read More

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October 2018
11 Reads

Whether Thymoma Patients in Myasthenia Crisis Could Benefit from Immediate Resection of Tumor Compared with Selective Surgery after Stabilization of MC.

Ann Thorac Cardiovasc Surg 2018 Oct 31. Epub 2018 Oct 31.

Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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October 2018
1 Read
0.687 Impact Factor

Verification of the diagnostic strategy for anterior mediastinal tumors.

Int J Clin Oncol 2018 Oct 29. Epub 2018 Oct 29.

Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Background: For thymic epithelial tumors (TETs), the National Comprehensive Cancer Network guideline has suggested that complete excision of the tumor should be performed without a preoperative biopsy when resectable. However, little evidence has been provided to support this strategy. The purpose of this study was to review our diagnostic process and to evaluate the validity of radical resection of anterior mediastinal masses (AMMs) without pathological confirmation. Read More

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October 2018
4 Reads

Best practices for the management of thymic epithelial tumors: A position paper by the Italian collaborative group for ThYmic MalignanciEs (TYME).

Cancer Treat Rev 2018 Dec 5;71:76-87. Epub 2018 Oct 5.

Department of Medical Oncology, Humanitas Clinical and Research Hospital, Rozzano (Milan), Italy.

Thymic epithelial tumors (TETs) are a heterogenous group of rare tumors, with a complex histopatological classification. Furthermore, the recent introduction of the first TNM staging system, that is scheduled to replace the Masaoka-Koga system, may create further difficulties in TET management, that remains challenging. Several guidelines for treatment of TETs are available and provide recommendations based mainly on non randomized trials and retrospective or limited series. Read More

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December 2018
3 Reads

Recurrent Opportunistic Infections in a Thymectomised Patient with Myasthenia Gravis and Good's Syndrome.

Cureus 2018 Aug 10;10(8):e3130. Epub 2018 Aug 10.

Neurology, University of Missouri, Columbia, USA.

We report the case of a 65-year-old man with myasthenia gravis, who developed recurrent opportunistic infections following thymectomy and immunosuppressive therapy. Subsequent evaluation including immunological studies, flow cytometry, and bone marrow studies confirmed the diagnosis of Good's syndrome. The patient was successfully treated with intravenous immunoglobulin (IVIG) and has remained stable with a monthly IVIG regimen. Read More

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August 2018
1 Read

Iodine Quantification Using Dual-Energy Computed Tomography for Differentiating Thymic Tumors.

J Comput Assist Tomogr 2018 Nov/Dec;42(6):873-880

From the Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, and.

The aim of the study was to explore the efficacy of iodine quantification with dual-energy computed tomography (DECT) in differentiating thymoma, thymic carcinoma, and thymic lymphoma.

Materials And Methods: Fifty-seven patients with pathologically confirmed low-risk thymoma (n = 16), high-risk thymoma (n = 15), thymic carcinoma (n = 14), and thymic lymphoma (n = 12) underwent chest contrast-enhanced DECT scan were enrolled in this study. Tumor DECT parameters including iodine-related Hounsfield unit (IHU), iodine concentration (IC), mixed HU (MHU), and iodine ratio in dual phase, slope of energy spectral HU curve (λ), and virtual noncontrast (VNC) were compared for differences among 4 groups by one-way analysis of variance. Read More

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November 2018
7 Reads

Frequent mutations in CD8 T cells from patients with pure red cell aplasia.

Blood Adv 2018 Oct;2(20):2704-2712

Division of Hematology, Department of Internal Medicine, School of Medicine.

Dysregulation of T-cell-mediated immunity is responsible for acquired pure red cell aplasia (PRCA). Although mutations are frequently detected in patients with T-cell large granular lymphocytic leukemia (T-LGLL), which is often complicated by PRCA and which is also reported to be associated with acquired aplastic anemia (AA) and myelodysplastic syndrome (MDS), whether -mutated T cells are involved in the pathophysiology of PRCA and other types of bone marrow failure remains unknown. We performed mutation analyses of the peripheral blood mononuclear cells from PRCA patients (n = 42), AA (n = 54), AA-paroxysmal nocturnal hemoglobinuria (AA-PNH; n = 7), and MDS (n = 21) using an allele-specific polymerase chain reaction and amplicon sequencing. Read More

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October 2018
12 Reads

Nerve sparing surgery in advanced stage thymomas.

Ann Thorac Surg 2018 Oct 15. Epub 2018 Oct 15.

Division of Thoracic Surgery; Cardiac. Thoracic and Vascular Department. University of Pisa, Pisa, Italy.

Background: Phrenic nerve infiltration has been described in up to 33% of advanced thymomas; en-bloc resection causes diaphragmatic loss of function, with detrimental effects on pulmonary function. We report the outcomes of selected patients operated on for invasive thymoma with a "nerve sparing" technique.

Methods: From 1990 to 2015 we used "nerve sparing" surgery with the intention to treat all patients with advanced stage thymomas without preoperative evidence of hemi-diaphragmatic palsy, but with macroscopical evidence of phrenic nerve involvement. Read More

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October 2018
1 Read

A Novel Platform for Cancer Vaccines: Antigen-Selective Delivery to Splenic Marginal Zone B Cells via Repeated Injections of PEGylated Liposomes.

J Immunol 2018 Nov 17;201(10):2969-2976. Epub 2018 Oct 17.

Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, Tokushima 770-8505, Japan;

Treating cancer with vaccines has been a challenge. In this study, we introduce a novel Ag delivery platform for cancer vaccines that delivers an encapsulated Ag to splenic marginal zone B (MZ-B) cells via the aid of a PEGylated liposome (PL) system. Splenic MZ-B cells have recently attracted interest as alternative APCs. Read More

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November 2018
1 Read

A novel prognostic signature of seven genes for the prediction in patients with thymoma.

J Cancer Res Clin Oncol 2018 Oct 17. Epub 2018 Oct 17.

Department of Oncology, Shenzhen Hospital, Southern Medical University, No. 1333, Xinhu Road, Bao'an District, Shenzhen, 518000, Guangdong Province, China.

Purpose: A thymoma is a tumor arising from the epithelium of the thymus, mostly occurring in the anterior mediastinum. The incidence of this disease is low and research progress in this field is slow. Consequently, there is an urgent need to investigate the correlation between molecular regulation and the prediction of survival and prognosis in patients with thymoma. Read More

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October 2018
2 Reads

AKT inhibition-mediated dephosphorylation of TFE3 promotes overactive autophagy independent of MTORC1 in cadmium-exposed bone mesenchymal stem cells.

Autophagy 2018 Oct 16:1-18. Epub 2018 Oct 16.

a Department of Environmental Medicine, and Department of Critical Care Medicine of the First Affiliated Hospital , Zhejiang University School of Medicine , Hangzhou , China.

Cadmium (Cd) is a toxic metal that is widely found in numerous environmental matrices and induces serious adverse effects in various organs and tissues. Bone tissue seems to be a crucial target of Cd contamination. Macroautophagy/autophagy has been proposed to play a pivotal role in Cd-mediated bone toxicity. Read More

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October 2018
2 Reads
11.750 Impact Factor

Superior Vena Cava Replacement for Thymic Malignancies.

Ann Thorac Surg 2018 Oct 11. Epub 2018 Oct 11.

Department of Thoracic Surgery, Sant'Andrea Hospital, Sapienza University of Rome.

Background: Advanced stage thymic tumours infiltrating Superior Vena Cava(SVC), when radically resectable, can be surgically treated by SVC prosthetic replacement within a multimodality therapeutic approach. We hereby present our series of patients undergoing SVC resection and prosthetic reconstruction for stage-III/IV thymic malignancies.

Methods: Between 1989 and 2015, 27 patients with thymic tumours(21 thymoma, 6 thymic carcinoma) infiltrating SVC underwent radical resection with SVC prosthetic replacement by a bovine pericardial conduit in 12 cases, a polytetrafluoroethylene(PTFE) conduit in 13, a porcine pericardial conduit in 1 and saphenous vein conduit in 1. Read More

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October 2018
2 Reads

Clinicopathological Features of Thymoma with the Expression of Programmed Death-Ligand 1.

Ann Thorac Surg 2018 Oct 9. Epub 2018 Oct 9.

Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, Japan.

Background: Programmed death-ligand 1 (PD-L1) is reportedly expressed in various malignancies and is considered a prognostic factor. We attempted to reveal the usefulness of the PD-L1 expression as a prognostic factor in patients with thymoma.

Methods: Eighty-one patients with thymoma who underwent surgical resection between 2004 and 2015 were retrospectively reviewed. Read More

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October 2018
2 Reads

Clinical differences of early and late-onset myasthenia gravis in 985 patients.

Neurol Res 2018 Oct 12:1-7. Epub 2018 Oct 12.

e Department of Neurology , Tangdu Hospital, Fourth Military Medical University , Xi'an , China.

Objective: The clinical differences of early-onset myasthenia gravis (EOMG) and late-onset MG (LOMG) have not been elucidated in China. In order to clarify this, a retrospective study was conducted in 985 MG patients, whose disease duration was longer than 3 years.

Methods: These patients were separated into EOMG and LOMG according to the onset age of 50 years. Read More

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October 2018
6 Reads

Lipofibroadenoma with B1 thymoma: A case report of a rare thymic tumor.

Indian J Pathol Microbiol 2018 Oct-Dec;61(4):630-632

Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

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October 2018
2 Reads
0.642 Impact Factor

Comparative study of video-assisted thoracoscopic surgery versus open thymectomy for thymoma and myasthenia gravis.

Wideochir Inne Tech Maloinwazyjne 2018 Sep 16;13(3):376-382. Epub 2018 May 16.

Department of Thoracic Surgery, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Introduction: Thymectomy is the preferred standard treatment in younger non-thymoma patients with myasthenia gravis as well as in patients with early stage thymoma. Total thymectomy by median sternotomy has been the surgical approach since resection of the thymus with video-assisted thoracoscopic surgery (VATS).

Aim: To compare the clinical outcomes of VATS thymectomy with conventional open thymectomy for neoplastic and non-neoplastic thymic diseases. Read More

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September 2018
4 Reads

T-lymphoblastic lymphoma after previous thymoma: how NGS helps establishing the diagnosis and procures new insights.

Leuk Lymphoma 2018 Oct 10:1-4. Epub 2018 Oct 10.

c Institute of Medical Genetics and Pathology, University Hospital Basel , Basel , Switzerland.

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October 2018
2 Reads

Selected Case From the Arkadi M. Rywlin International Pathology Slide Seminar: Atypical Thymoma With Rhabdomyomatous Differentiation.

Adv Anat Pathol 2019 Jan;26(1):64-68

Department of Pathology, Medical College of Wisconsin, Milwaukee, WI.

Thymic epithelial neoplasms with foci of rhabdomyomatous differentiation are rare. A case is presented of a primary thymic epithelial neoplasm showing the features of an atypical spindle cell thymoma that contained foci of bland-appearing rhabdomyomatous cells. The histologic and immunohistochemical features of this tumor are discussed along with a review of the literature and the comments from the AMR members to the case. Read More

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January 2019
8 Reads

[Interpretation of the fourth edition of WHO pathological classification of the thyroid tumors in 2017].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;53(9):718-720

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Pathological Department, Sun Yat-sen University, Cancer Center, Guangzhou 510060, China.

In recent years, the incidence of thyroid carcinoma gradually increased in China. The pathology diagnosis and classification was based on WHO classification of Tumors of Endocrine Organs, the third edition which published in 2004. The fourth edition, WHO classification of Tumors of Endocrine Organs was published in July 2017. Read More

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September 2018
8 Reads

A Good Case of Recurrent Pneumonia.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618802869. Epub 2018 Sep 29.

Emory University School of Medicine, Atlanta, GA, USA.

infection is a common cause of pneumonia in animals but rarely causes disease in humans. Additionally, coinfection with is very uncommon and is occasionally seen in patients with acquired immunodeficiency syndrome (AIDS). We report a case of a 61-year-old HIV-negative man, who presented with hypoxic respiratory failure 2 days after completion of systemic intravenous antibiotic treatment for His past medical history was significant for a benign thymoma. Read More

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September 2018
2 Reads

Thymoma and Limbic Encephalitis: A Dangerous Liaison.

Prim Care Companion CNS Disord 2018 Sep 27;20(5). Epub 2018 Sep 27.

Department of Neurology, Maltepe University, Faculty of Medicine, Istanbul, Turkey.

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September 2018
5 Reads

Evaluation of the prognostic value of surgery and postoperative radiotherapy for patients with thymic neuroendocrine tumors: A propensity-matched study based on the SEER database.

Thorac Cancer 2018 Dec 1;9(12):1603-1613. Epub 2018 Oct 1.

Department of Thoracic Surgery, The Second Affiliated Hospital of Soochow University, Medical College of Soochow University, Suzhou, China.

Background: The prognostic value of surgery and postoperative radiotherapy (PORT) for primary thymic neuroendocrine tumors (TNETs) was estimated using the SEER database.

Methods: This retrospective study used SEER data of TNET patients between 1998 and 2015. Propensity score matching (PSM) was performed according to whether surgery was performed. Read More

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December 2018
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Progress in targeted therapy for breast cancer.

Chronic Dis Transl Med 2018 Sep 7;4(3):164-175. Epub 2018 Jul 7.

Department of VIP Medical Services, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Breast cancer is a multistep, multifactorial, and heterogeneous disease. Significant transformations have occurred in the systemic management of breast cancer in the past decade. Due to the further understanding of pathogenesis, scientists have found plenty of signaling pathways and correspondingly therapeutic targets in breast cancer, such as hormone receptor, human epidermal growth factor receptor 2 (HER2), epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), phosphoinositide-3-kinase (PI3K), v-akt murine thymoma viral oncogene homolog (AKT), mechanistic target of rapamycin (mTOR), cyclin-dependent kinase 4/6 (CDK4/6), poly (adenosine diphosphate-ribose) polymerase (PARP), and programmed death-1 (PD-1). Read More

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September 2018
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