228 results match your criteria Thymic Lesion Imaging

Mucoepidermoid carcinoma of the thymus incidentally diagnosed following two-years of non-productive cough.

Radiol Case Rep 2021 Aug 11;16(8):2158-2163. Epub 2021 Jun 11.

Department of Radiology, SUNY Upstate Medical University, Syracuse, NY.

Mucoepidermoid carcinoma of the thymus is a rare primary thymic carcinoma. Radiologic imaging of this malignancy is rarely reported in literature. We present a patient who complained of a chronic cough for two years who was later found to have mucoepidermoid carcinoma of the thymus. Read More

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Predicting Masaoka-Koga Clinical Stage of Thymic Epithelial Tumors Using Preoperative Spectral Computed Tomography Imaging.

Front Oncol 2021 25;11:631649. Epub 2021 Mar 25.

Lanzhou University Second Hospital, Lanzhou, China.

Objectives: To investigate the utility of spectral computed tomography (CT) parameters for the prediction of the preoperative Masaoka-Koga stage of thymic epithelial tumors (TETs).

Materials And Methods: Fifty-four patients with TETs, aged from 37 to 73 years old, an average age of 55.56 ± 9. Read More

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Physiological Biodistribution of Ga-DOTA-TATE in Normal Subjects

Mol Imaging Radionucl Ther 2021 02;30(1):39-46

Marmara University Pendik Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey.

Objectives: Somatostatin is an endocrine peptide hormone that regulates neurotransmission and cell proliferation by interacting with G protein-coupled somatostatin receptors (SSTRs). SSTRs are specific molecular targets of several radiotracers for neuroendocrine tumor (NET) imaging. Gallium-68 (Ga)-DOTA-TATE is widely used for positron emission tomography/computed tomography (PET/CT) imaging of SSTRs and has shown a higher affinity for SSTR2, the most common SSTR subtype found in NETs. Read More

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February 2021

Prognostic Significance of Metabolic Parameters by F-FDG PET/CT in Thymic Epithelial Tumors.

Cancers (Basel) 2021 Feb 9;13(4). Epub 2021 Feb 9.

Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.

Background: Imaging tumor FDG avidity could complement prognostic implication in thymic epithelial tumors. We thus investigated the prognostic value of volume-based F-fluorodeoxyglucose (F-FDG) positron emission tomography (PET)/CT parameters in thymic epithelial tumors with other clinical prognostic factors.

Methods: This is a retrospective study that included 83 patients who were diagnosed with thymic epithelial tumors and underwent pretreatment F-FDG PET/CT. Read More

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February 2021

Thymic Hyperplasia with Lymphoepithelial Sialadenitis (LESA)-Like Features: Strong Association with Lymphomas and Non-Myasthenic Autoimmune Diseases.

Cancers (Basel) 2021 Jan 16;13(2). Epub 2021 Jan 16.

Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.

Thymic hyperplasia (TH) with lymphoepithelial sialadenitis (LESA)-like features (LESA-like TH) has been described as a tumor-like, benign proliferation of thymic epithelial cells and lymphoid follicles. We aimed to determine the frequency of lymphoma and autoimmunity in LESA-like TH and performed retrospective analysis of cases with LESA-like TH and/or thymic MALT-lymphoma. Among 36 patients (21 males) with LESA-like TH (age 52 years, 32-80; lesion diameter 7. Read More

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January 2021

How to obtain adequate biopsy specımen in suspected thymic tumors.

J Thorac Dis 2020 Dec;12(12):7598-7606

University of Health Sciences-Turkey, Izmir Dr. Suat Seren Training and Research Hospital for Thoracic Medicine and Surgery, Izmir, Turkey.

Pathologic diagnosis of thymic tumors (TTs) can be made by surgical or nonsurgical procedures. About 20% of TTs had been diagnosed by pretreatment biopsy methods while the rest had gone to surgery for diagnosis and treatment. However, in the last two decades there was an increase in pretreatment procedures for optimal management of locally advanced or metastatic TTs. Read More

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December 2020

The role of radiological imaging for masses in the prevascular mediastinum in clinical practice.

J Thorac Dis 2020 Dec;12(12):7591-7597

Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Tumors in the prevascular compartment of the mediastinum are rare and imaging plays a major role in their detection, (differential) diagnosis, staging, and follow-up. The prevascular compartment is bordered anteriorly by the posterior aspect of the sternum, posteriorly by the ventral aspect of the pericardium, cranially by the thoracic outlet, and caudally by the diaphragm. In many cases, the diagnosis of a lesion in the prevascular compartment is an incidental finding either on chest radiograph (CR) or on computed tomography (CT) scans. Read More

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December 2020

Administration of CD4CD25CD127FoxP3 Regulatory T Cells for Relapsing-Remitting Multiple Sclerosis: A Phase 1 Study.

BioDrugs 2021 Jan 5;35(1):47-60. Epub 2021 Jan 5.

Department of Medical Immunology, Medical University of Gdańsk, Debinki 7, 80-210, Gdańsk, Poland.

Background: Multiple sclerosis (MS) is an immune-mediated disease in which autoimmune T conventional (T) cells break the blood-brain barrier and destroy neurons of the central nervous system. It is hypothesized that CD4CD25CD127FoxP3 T regulatory (T) cells may inhibit this destruction through suppressive activity exerted on T cells.

Methods: We present the results of a phase 1b/2a, open-label, two-arm clinical trial in 14 patients treated with autologous T cells for relapsing-remitting MS. Read More

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January 2021

Identification of regulatory T cell molecules associated with severity of multiple sclerosis.

Mult Scler 2020 Dec 10:1352458520977045. Epub 2020 Dec 10.

Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico/Escuela de Medicina y Ciencias de la Salud, Tecnológico de Monterrey, Monterrey, Mexico.

Background: Regulatory CD4 T cells (Tregs) exhibit functional alterations in patients with multiple sclerosis (MS). Transforming growth factor (TGF)-β is a key regulator of Treg development and function.

Objective: The objective of this study is to determine whether the expression of functionally relevant TGF-β-regulated molecules is altered in Tregs from patients with MS. Read More

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December 2020

Multilocular Thymic Cyst in a Young, Otherwise Healthy Woman: A Case Report.

Cureus 2020 Oct 28;12(10):e11210. Epub 2020 Oct 28.

Department of Thoracic Surgery, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, GRC.

Thymic cysts are rare lesions, accounting approximately for 1% of all mediastinal masses. We report a case of a 36-year old woman who presented preoperatively with a calcified mass shadow found on a routine chest radiograph X-ray. After further investigation with chest computed tomography (CT), magnetic resonance imaging (MRI), and tests for Myasthenia gravis, a benign mediastinal cyst was diagnosed and the patient underwent median sternotomy and complete surgical excision of the lesion. Read More

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October 2020

An Intraocular Thymic Metastasis Identified on 18F-FDG PET/CT Before and After Treatment.

Clin Nucl Med 2021 Mar;46(3):240-242

From the Department of Molecular Imaging, Royal Prince Alfred Hospital, Camperdown.

Abstract: We present the imaging findings pretreatment and posttreatment in a 58-year-old woman with recurrent thymic carcinoma. Two years after treatment, the patient presented with a 3-week history of right eye pain and blurred vision. Ophthalmological examination and MRI of the orbits showed a right superolateral choroidal lesion. Read More

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Direct Intraesophageal Growth from Metastatic Mediastinal Lymphadenopathy in Thymic Carcinoma.

Intern Med 2021 Mar 21;60(6):923-926. Epub 2020 Oct 21.

Department of Centarl Laboratory, Shinshu University School of Medicine, Japan.

We herein report a case of thymic carcinoma that initially exhibited dysphagia and an intraesophageal mass lesion. A 68-year-old man was admitted to our hospital because of dysphagia. An endoscopic examination revealed a mass on the middle esophagus. Read More

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[Different Energy Spectrum CT Findings between Anterior Mediastinal Lymphoma and Thymic Carcinoma].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2020 Aug;42(4):431-435

College of Traditional Chinese Medicine,North China University of Science and Technology,Tangshan,Hebei 063000,China.

To investigate the differences in energy spectrum CT findings between anterior mediastinal lymphoma and thymic carcinoma. Twenty-two cases of anterior mediastinal lymphoma and 28 cases of thymic carcinoma confirmed by biopsy in Tangshan People's Hospital were selected.The CT values and changes of iodine content and water content in lesion sites were measured by energy spectrum analysis software. Read More

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Multilocular thymic cyst in a patient with preclinical rheumatoid arthritis: A case report.

Int J Surg Case Rep 2020 15;74:136-139. Epub 2020 Aug 15.

Department of Thoracic Surgery, National Hospital Organization Yamaguchi Ube Medical Center, 685 Higashikiwa Ube Yamaguchi, 755-0241, Japan. Electronic address:

Introduction: Multilocular thymic cyst (MTC) is a rare condition of an acquired multilocular cystic lesion caused by inflammation and often associated with autoimmune diseases or malignant tumors. We present a patient with MTC and asymptomatic rheumatoid arthritis (RA), which is termed preclinical RA.

Presentation Of Case: A 60-year-old man underwent a computed tomography scan, which revealed an 8. Read More

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Long-Term Follow-Up Ultrasonographic Findings of Intrathyroidal Thymus in Children.

Korean J Radiol 2020 11 22;21(11):1248-1255. Epub 2020 Jul 22.

Department of Radiology, Soonchunhyang University Hospital Seoul, Seoul, Korea.

Objective: To analyze long-term follow-up sonographic findings of intrathyroidal thymus in children.

Materials And Methods: Among 1259 patients with congenital hypothyroidism under 15 years of age who underwent thyroid ultrasonography (US), 41 patients were diagnosed with an intrathyroidal thymus based on US criteria, i.e. Read More

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November 2020

Carcinoma Showing Thymus-Like Differentiation (CASTLE) Arising in the Sublingual Gland.

Int J Surg Pathol 2021 May 16;29(3):301-307. Epub 2020 Jul 16.

9297University of Brescia, Brescia, Italy.

Carcinoma showing thymic-like differentiation (CASTLE) is a rare tumor most commonly occurring in the thyroid and soft tissues of the neck. We report the first case of CASTLE occurring in the sublingual gland. The patient, a 35-year-old healthy man, presented with a submucosal lesion located in the anterior right floor of the oral cavity and an ipsilateral neck mass. Read More

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Giant cervicomediastinal thymic cyst in an elderly: diagnosis by multimodality imaging and fine-needle aspiration cytology with immunocytochemistry.

BMJ Case Rep 2020 Jul 6;13(7). Epub 2020 Jul 6.

Pulmonary Medicine, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, Odisha, India.

A 65-year-old woman, a non-smoker, presented to the pulmonary medicine outpatient department with chest pain, mild dyspnoea, right side neck swelling and mild facial puffiness. The cervical swelling was soft, non-tender and fluctuant on palpation. Multimodality imaging revealed a large, thin-walled cervicomediastinal cystic lesion with septations, haemorrhage, septal calcification and without any solid component. Read More

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Value of metabolic parameters in distinguishing primary mediastinal lymphomas from thymic epithelial tumors.

Cancer Biol Med 2020 05;17(2):468-477

Department of Molecular Imaging and Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.

A high rate of unnecessary thymectomies has been reported. This study aimed to distinguish primary mediastinal lymphomas (PMLs) from thymic epithelial tumors (TETs) by evaluating volumetric and metabolic parameters with F-FDG PET/CT. A total of 136 patients who were pathologically diagnosed with TETs or PMLs were enrolled, and F-FDG PET/CT was performed before therapy. Read More

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Are volume-dependent parameters in positron emission tomography predictive of postoperative recurrence after resection in patients with thymic carcinoma?

Surg Today 2021 Feb 13;51(2):322-326. Epub 2020 Jun 13.

Department of Thoracic Surgery, Kyoto University Hospital, 54 Kawahara-cho, Sakyo-ku, Kyoto, 604-0984, Japan.

This study aimed to investigate the association between the volume-dependent parameters in F-fluorodeoxyglucose-positron emission tomography (F-FDG PET/CT) and a recurrence of thymic carcinoma. A retrospective chart review was performed based on our multi-institutional database to identify patients undergoing PET prior to resection of thymic carcinoma or neuroendocrine carcinoma between 1991 and 2018. The PET parameters (metabolic tumor volume and total lesion glycolysis) were evaluated retrospectively. Read More

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February 2021

Endoscopic ultrasound ablation in a patient with multiple metastatic pancreatic tumors from adrenocorticotropic hormone-producing thymic neuroendocrine neoplasm.

Dig Endosc 2021 Mar 18;33(3):458-463. Epub 2020 Aug 18.

Departments of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Adrenocorticotropic hormone (ACTH)-producing neuroendocrine neoplasm (NEN) of the thymus is rare. Lymph nodes and bones are the most common metastatic sites. Most cases present with florid Cushing's syndrome (CS). Read More

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Recurrent Thymoma-Associated Paraneoplastic Encephalitis Resulting From Multiple Antibodies: A Case Report.

Neurohospitalist 2020 Apr 13;10(2):139-142. Epub 2019 Oct 13.

Department of Neurology, MedStar Georgetown University Hospital, Washington, DC, USA.

Few reports describe the clinical course and acute-care management of patients with recurrent multi-antibody paraneoplastic encephalitis. We describe a rare case of a patient having thymoma with multiple paraneoplastic syndromes who was found to have antibodies to α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) followed by -methyl-d-aspartate (NMDA) receptor in the setting of residual thymic tissue. He initially presented to the hospital with severe, rapidly progressive encephalitis with simultaneous antibodies to AMPA and voltage-gated potassium channel complex receptor. Read More

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Computed tomography (CT)-derived radiomic features differentiate prevascular mediastinum masses as thymic neoplasms versus lymphomas.

Radiol Med 2020 Oct 18;125(10):951-960. Epub 2020 Apr 18.

Department of Biomedical Sciences, Humanitas University, via Rita Levi Montalcini, 4, 20090, Pieve Emanuele, Milano, Italy.

Objectives: We aimed to assess the ability of radiomics, applied to not-enhanced computed tomography (CT), to differentiate mediastinal masses as thymic neoplasms vs lymphomas.

Methods: The present study was an observational retrospective trial. Inclusion criteria were pathology-proven thymic neoplasia or lymphoma with mediastinal localization, availability of CT. Read More

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October 2020

Cystic thymic degeneration with pseudoepitheliomatous hyperplasia in a Beagle puppy: an idiopathic lesion?

J Vet Diagn Invest 2020 May 10;32(3):435-439. Epub 2020 Apr 10.

Department of Veterinary Medicine, University of Perugia, Perugia, Italy.

A 6-mo-old female Beagle dog was inappetent and depressed. The radiographic, ultrasonographic, and computed tomographic examination of the chest revealed a 10 × 7 cm multicystic mediastinal structure interpreted as altered thymus, in association with moderate pleural effusion that laboratory tests confirmed as hemothorax. No history of trauma or anticoagulant drug intoxication was reported, and no coagulation disorders were detected. Read More

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Machine-learning-based computed tomography radiomic analysis for histologic subtype classification of thymic epithelial tumours.

Eur J Radiol 2020 May 2;126:108929. Epub 2020 Mar 2.

Department of Radiology, The First Affiliated Hospital of Fujian Medical University, 20 ChaZhong Rd, Fuzhou, Fujian, 350005, PR China. Electronic address:

Purpose: To evaluate the performance of machine-learning-based computed tomography (CT) radiomic analysis to differentiate high-risk thymic epithelial tumours (TETs) from low-risk TETs according to the WHO classification.

Method: This retrospective study included 155 patients with a histologic diagnosis of high-risk TET (n = 72) and low-risk TET (n = 83) who underwent unenhanced CT (UECT) and contrast-enhanced CT (CECT). The radiomic features were extracted from the UECT and CECT of each patient at the largest cross-section of the lesion. Read More

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Value of 18F-FDG PET/computed tomography in predicting the simplified WHO grade of malignancy in thymic epithelial tumors.

Nucl Med Commun 2020 Apr;41(4):405-410

Department of Nuclear Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Objective: To investigate the value of 18F-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) in predicting the simplified WHO grade of malignancy in thymic epithelial tumors.

Materials And Methods: We retrospectively reviewed 81 patients with pathologically proven thymic epithelial tumors who underwent F-FDG PET/CT before surgical resection. Maximum standardized uptake value (SUVmax) and SUVmax/tumor size were measured on the primary lesion. Read More

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Predictive Features of Thymic Carcinoma and High-Risk Thymomas Using Random Forest Analysis.

J Comput Assist Tomogr 2020 Nov/Dec;44(6):857-864

From the The Second School of Clinical Medicine, Southern Medical University, and Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou.

Purpose: To determine the predictive features of thymic carcinomas and high-risk thymomas using random forest algorithm.

Methods: A total of 137 patients with pathologically confirmed high-risk thymomas and thymic carcinomas were enrolled in this study. Three clinical features and 20 computed tomography features were reviewed. Read More

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December 2020

Distribution of Mediastinal Lesions Across Multi-Institutional, International, Radiology Databases.

J Thorac Oncol 2020 04 20;15(4):568-579. Epub 2019 Dec 20.

The Chaim Sheba Medical Center, affiliated with the Tel Aviv University, Tel Aviv, Israel.

Introduction: Mediastinal lesions are uncommon; studies on their distribution are, in general, small and from a single institution. Furthermore, these studies are usually based on pathology or surgical databases and, therefore, miss many lesions that did not undergo biopsy or resection. Our aim was to identify the distribution of lesions in the mediastinum in a large international, multi-institutional cohort. Read More

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Update in diagnostic imaging of the thymus and anterior mediastinal masses.

Gland Surg 2019 Sep;8(Suppl 3):S188-S207

Department of Medicine, Surgery and Neuro Sciences, Diagnostic Imaging, University of Siena, Azienda Ospedaliera Universitaria Senese, Siena, Italy.

Anterior mediastinal masses include a wide spectrum of malignant and benign pathologies with a large percentage represented by thymic lesions. Distinguishing these masses on diagnostic imaging is fundamental to guide the proper management for each patient. This review illustrates possibilities and limits of different imaging modalities to diagnose a lesion of the anterior mediastinum with particular attention to thymic disease. Read More

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September 2019

Challenges in diagnosing ectopic thymus tissue in children.

BMJ Case Rep 2019 Sep 17;12(9). Epub 2019 Sep 17.

Paediatrics, Antwerp University Hospital, University of Antwerp, Edegem, Belgium.

The presentation of a fast-growing cervical mass necessitates prompt attention due to risk of the mass effect on vital structures and requires preferential screening for infections, bleeding and malignancies in an extensive list of differential diagnoses. This case report describes a 4.5-year-old boy with a fast-growing, unilateral lesion in the neck, with clinical features in keeping with malignant characteristics. Read More

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September 2019