251 results match your criteria Thymic Lesion Imaging


Fully Automatic Quantitative Measurement of 18F-FDG PET/CT in Thymic Epithelial Tumors Using a Convolutional Neural Network.

Clin Nucl Med 2022 Jul 27;47(7):590-598. Epub 2022 Apr 27.

From the Departments of Nuclear Medicine.

Objectives: The aim of this study was to develop a deep learning (DL)-based segmentation algorithm for automatic measurement of metabolic parameters of 18F-FDG PET/CT in thymic epithelial tumors (TETs), comparable performance to manual volumes of interest.

Patients And Methods: A total of 186 consecutive patients with resectable TETs and preoperative 18F-FDG PET/CT were retrospectively enrolled (145 thymomas, 41 thymic carcinomas). A quasi-3D U-net architecture was trained to resemble ground-truth volumes of interest. Read More

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Ectopic intrathyroidal thymic tissue in an adult patient: a case report and review of the literature.

J Med Case Rep 2022 May 25;16(1):224. Epub 2022 May 25.

Division of Neuroradiology and Head & Neck Imaging, Department of Radiology, Tehran University of Medical Sciences, Tehran, Iran.

Background: Ectopic intrathyroidal thymic tissue is a rare diagnosis, specifically in adults. Such ectopic tissue is usually misdiagnosed as benign or malignant thyroid lesions and is mainly investigated by ultrasonography and pathologic examination.

Case Presentation: We present the case of an adult 31-year-old Persian female patient with a cervical mass and no other significant medical history. Read More

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Fetal thoracic teratomas: mediastinal or pericardial?

Pediatr Radiol 2022 Apr 26. Epub 2022 Apr 26.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background: Mediastinal and pericardial teratomas have overlapping imaging features that may make accurate prenatal diagnosis challenging.

Objective: To identify prenatal imaging features that may aid in distinguishing between mediastinal and pericardial teratomas.

Materials And Methods: Prenatally diagnosed pericardial and mediastinal teratomas evaluated at our fetal center from 1995 to 2020 were included in this Institutional Review Board-approved study. Read More

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The efficacy of F-FDG-PET-based radiomic and deep-learning features using a machine-learning approach to predict the pathological risk subtypes of thymic epithelial tumors.

Br J Radiol 2022 Jun 28;95(1134):20211050. Epub 2022 Mar 28.

Department of Radiology, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Objective: To examine whether the machine-learning approach using 18-fludeoxyglucose positron emission tomography (F-FDG-PET)-based radiomic and deep-learning features is useful for predicting the pathological risk subtypes of thymic epithelial tumors (TETs).

Methods: This retrospective study included 79 TET [27 low-risk thymomas (types A, AB and B1), 31 high-risk thymomas (types B2 and B3) and 21 thymic carcinomas] patients who underwent pre-therapeutic F-FDG-PET/CT. High-risk TETs (high-risk thymomas and thymic carcinomas) were 52 patients. Read More

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MRI Findings and Differential Diagnosis of Anterior Mediastinal Solid Tumors.

Magn Reson Med Sci 2022 Mar 17. Epub 2022 Mar 17.

Department of Radiology, Faculty of Medicine, Saga University.

The anterior mediastinum is the most common location of mediastinal tumors, and thymic epithelial tumors are the most common mediastinal tumors. It is important to differentiate thymic epithelial tumors from malignant lymphomas and malignant germ cell tumors because of the different treatment strategies. Dynamic contrast-enhanced MRI and diffusion-weighted imaging can provide additional information on the differential diagnosis. Read More

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Multiple electrolyte disturbances as the presenting feature of multiple endocrine neoplasia type 1 (MEN-1).

Endocrinol Diabetes Metab Case Rep 2022 Mar 1;2022. Epub 2022 Mar 1.

Department of Endocrinology ASO/EASO COM, King 's College Hospital NHS Foundation Trust, Denmark Hill, London, UK.

Summary: A 49-year-old teacher presented to his general physician with lethargy and lower limb weakness. He had noticed polydipsia, polyuria, and had experienced weight loss, albeit with an increase in central adiposity. He had no concomitant illnesses and took no regular medications. Read More

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Cervical Thymic Cyst with parathyroid tissue - a diagnostic conundrum.

Autops Case Rep 2022 21;12:e2021361. Epub 2022 Feb 21.

All India Institute of Medical Sciences, Department of Pathology and Lab Medicine, Jodhpur, Rajasthan, India.

Cervical thymic cysts are relatively rare benign cystic lesions that tend to be diagnosed clinically as branchial cysts, which usually present as painless, enlarging neck masses. They can occur anywhere along the normal path of descent of thymic primordia from the angle of the mandible to the sternal notch, with mediastinal extension observed in approximately 50% of cases. They are usually seen in the first decade of life on the left side with a male predominance. Read More

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February 2022

Clinical practices for non-neoplastic thymic lesions: Results from a multidisciplinary cohort.

Lung Cancer 2022 04 22;166:76-83. Epub 2022 Feb 22.

University of Lyon, University Claude Bernard Lyon 1, Lyon, France; Institut Curie, Institut du Thorax Curie Montsouris, Paris, France. Electronic address:

Background: Non-neoplastic thymic lesions are uncommon findings that corresponds to multiple histological and clinical entities that may be difficult to differentiate from thymic malignancies. In this study, our main objective was to describe the clinical, imaging and pathological characteristics of non-neoplastic thymic lesions in a large cohort of patients. We also aimed at understanding the key factors that led to a decision to surgically resect those lesions. Read More

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A Rare Case of Brain Metastasis of Thymic Carcinoma.

Anticancer Res 2022 Feb;42(2):1169-1174

Department of Neurosurgery, Nara Medical University, Kashihara, Japan.

Background: Thymic carcinoma is a rare cancer that often metastasizes to the liver and kidneys but rarely to the brain.

Case Report: We present a rare case of an 81-year-old woman with multiple cerebellar metastases of thymic carcinoma. She was initially diagnosed with stage IVb thymic carcinoma based on biopsy examination of a lesion in the anterior mediastinum. Read More

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February 2022

CT-Based Radiomics Nomogram for Differentiation of Anterior Mediastinal Thymic Cyst From Thymic Epithelial Tumor.

Front Oncol 2021 10;11:744021. Epub 2021 Dec 10.

Department of Radiology, Yantai Yuhuangding Hospital, Affiliated Hospital of Qingdao University, Yantai, China.

Objectives: This study aimed to distinguish preoperatively anterior mediastinal thymic cysts from thymic epithelial tumors a computed tomography (CT)-based radiomics nomogram.

Methods: This study analyzed 74 samples of thymic cysts and 116 samples of thymic epithelial tumors as confirmed by pathology examination that were collected from January 2014 to December 2020. Among the patients, 151 cases (scanned at CT 1) were selected as the training cohort, and 39 cases (scanned at CT 2 and 3) served as the validation cohort. Read More

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December 2021

Primary Hyperparathyroidism as a Rare Cause of Unexplained Recurrent Abdominal Pain: Case Presentation and Literature Review.

Cureus 2021 Oct 31;13(10):e19155. Epub 2021 Oct 31.

Pediatric Surgery, King Abdulaziz Medical City, Jeddah, SAU.

Abdominal pain is a common symptom in surgical practice. Around 11%-45% of pediatric population present with abdominal pain. In 29%-87. Read More

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October 2021

Role of quantitative energy spectrum CT parameters in differentiating thymic epithelial tumours and thymic cysts.

Clin Radiol 2022 02 29;77(2):136-141. Epub 2021 Nov 29.

Department of Radiology, Lanzhou University Second Hospital, Gansu, China; Key Laboratory of Medical Imaging of Gansu Province, Lanzhou University Second Hospital, China; Gansu International Scientific and Technological Cooperation Base of Medical Imaging Artificial Intelligence, China. Electronic address:

Aim: To explore the utility of multiple energy spectrum computed tomography (CT) parameters in distinguishing thymic epithelial tumours (TETs) from thymic cysts among lesions <5 cm in diameter.

Materials And Methods: Data pertaining to 56 patients with TETs and thymic cysts <5 cm in diameter were assessed retrospectively. All patients underwent surgical resection and the diagnosis was confirmed histopathologically. Read More

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February 2022

Echographic findings in ectopic intrathyroidal thymic tissue in children. A systematic review.

Radiologia (Engl Ed) 2021 Nov-Dec;63(6):512-518

Grupo de Patología Oncológica, Instituto Nacional de Cancerología, Bogotá, Colombia; Instituto de investigación, Departamento de Patología, Fundación Universitaria de las Ciencias de la Salud, Bogotá, Colombia.

Intrathyroidal ectopic thymic tissue (IETT) is an indulgent, unusual entity and is part of the differential diagnosis of thyroid nodules in the pediatric population. Because of the low prevalence of IETT, the diagnosis may be difficult. Awareness of this diagnosis is definitive to avoid surgical interventions. Read More

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December 2021

Thymus pathology in myasthenia gravis with anti-acetylcholine receptor antibodies and concomitant Hashimoto's thyroiditis. A four-case series and literature review.

Rom J Morphol Embryol 2021 Jan-Mar;62(1):73-83

Department of Ophthalmology, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania;

Objective: Identifying the morphological features of thymus in patients with myasthenia gravis (MG) with anti-acetylcholine receptor (AChR) antibodies and concomitant Hashimoto's thyroiditis (HT), which were recruited from a single surgical unit of a tertiary referral hospital located in the North-Eastern region of Romania, over a period of 11 years.

Patients, Materials And Methods: We retrospectively reviewed clinical, imaging, laboratory, thymic pathology, and outcome data that were obtained from medical records of patients with MG and concomitant HT, to whom a thymectomy was performed for a suspected thymic lesion. All the surgical interventions were done in the Third Clinic of Surgery, St. Read More

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October 2021

A rare case of hepatic metastasis 20 years after surgical resection of a thymoma: A case report.

Int J Surg Case Rep 2021 Oct 15;87:106406. Epub 2021 Sep 15.

Department of Visceral and Minimal Invasive Surgery, Siloah Hospital, Hannover, Germany.

Introduction: Thymoma is the most common solid, primary mediastinal tumour, accounting for 20% of mediastinal neoplasms. Malignant thymus tumours (thymomas and thymic carcinomas) metastasize primarily locally. Distant metastases, especially to liver are very rare. Read More

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October 2021

Diagnostic and prognostic values of 2-[F]FDG PET/CT in resectable thymic epithelial tumour.

Eur Radiol 2022 Feb 26;32(2):1173-1183. Epub 2021 Aug 26.

Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.

Objectives: We aimed to evaluate the diagnostic ability for the prediction of histologic grades and prognostic values on recurrence and death of pretreatment 2-[F]FDG PET/CT in patients with resectable thymic epithelial tumours (TETs).

Methods: One hundred and fourteen patients with TETs who underwent pretreatment 2-[F]FDG PET/CT between 2012 and 2018 were retrospectively evaluated. TETs were classified into three histologic subtypes: low-risk thymoma (LRT, WHO classification A/AB/B1), high-risk thymoma (HRT, B2/B3), and thymic carcinoma (TC). Read More

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February 2022

Longitudinal CT and MRI Characteristics of Unilocular Thymic Cysts.

Radiology 2021 11 24;301(2):443-454. Epub 2021 Aug 24.

From the Department of Radiology, Division of Thoracic Imaging and Intervention, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Founders House 202, Boston, MA 02114.

Background Isoattenuating and hyperattenuating thymic cysts at CT are often misinterpreted as lymphadenopathy or thymic epithelial neoplasms. Purpose To evaluate the longitudinal change in thymic cyst appearance at CT and MRI. Materials and Methods All chest MRI studies showing thymic cysts between July 2008 and December 2019, identified from a retrospective search of a quality assurance database, were included in this study if initial CT depicted a thymic lesion, the patient was referred for follow-up MRI for characterization, and the baseline (ie, index) MRI indicated a cystic lesion. Read More

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November 2021

Primary mediastinal seminoma with florid follicular lymphoid hyperplasia: a case report and review of the literature.

Diagn Pathol 2021 Aug 21;16(1):76. Epub 2021 Aug 21.

Freeman Hospital, Newcastle upon Tyne, UK.

Background: First described in 1955 Primary mediastinal seminomas are rare. Only 1-4% of mediastinal tumours are germ cell tumors; majority of which are teratomas. They typically present in men aged between 20 and 40 years. Read More

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Correlation of clinical and computed tomography features of thymic epithelial tumours with World Health Organization classification and Masaoka-Koga staging.

Eur J Cardiothorac Surg 2022 03;61(4):742-748

Department of Radiology, Lanzhou University Second Hospital, Gansu, China.

Objectives: Our goal was to investigate the correlation of clinical and computed tomography (CT) features of thymic epithelial tumours (TET) with the World Health Organization classification and the Masaoka-Koga staging system.

Methods: Clinical and CT imaging data from 159 patients surgically and pathologically diagnosed with TET (82 men, 77 women; mean [± standard deviation] age, 52.08 ± 11. Read More

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Micronodular Thymoma with Lymphoid Stroma: A Case Report.

Tokai J Exp Clin Med 2021 Jul 20;46(2):94-96. Epub 2021 Jul 20.

Department of Thoracic Surgery, Chigasaki Municipal Hospital, Honson 5-15-1, Chigasaki, Kanagawa 253-0042, Japan.

Background: Micronodular thymoma with lymphoid stroma (MNT) is a rare subtype of thymic neoplasms. Therefore, clinical guidelines, histopathological diagnostic criteria, prognostic factors, and therapeutic regimens have not been established.

Case Presentation: A 69-year-old woman was admitted to our hospital because of an abnormal shadow detected by chest radiography. Read More

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Mucoepidermoid carcinoma of the thymus incidentally diagnosed following two-years of non-productive cough.

Radiol Case Rep 2021 Aug 11;16(8):2158-2163. Epub 2021 Jun 11.

Department of Radiology, SUNY Upstate Medical University, Syracuse, NY.

Mucoepidermoid carcinoma of the thymus is a rare primary thymic carcinoma. Radiologic imaging of this malignancy is rarely reported in literature. We present a patient who complained of a chronic cough for two years who was later found to have mucoepidermoid carcinoma of the thymus. Read More

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Multilocular thymic cyst (MTC) and other tumors with MTC features: Pitfalls in diagnosis.

Semin Diagn Pathol 2022 Mar 11;39(2):105-112. Epub 2021 Jun 11.

From the Department of Pathology at the University of Texas, M D Anderson Cancer Center, Houston, TX, USA.

Cystic lesions of the anterior mediastinum represent a well-known group of benign lesions that are relatively common in the general practice, namely in the pediatric age group. In the adult population, multilocular thymic cyst (MTC) plays an important role in occurrence as it presents as a cystic anterior mediastinal mass that clinically may mimic another anterior mediastinal tumor. In general, MTC is of rather unusual occurrence and its histopathological features have been well described in the literature. Read More

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Predicting Masaoka-Koga Clinical Stage of Thymic Epithelial Tumors Using Preoperative Spectral Computed Tomography Imaging.

Front Oncol 2021 25;11:631649. Epub 2021 Mar 25.

Lanzhou University Second Hospital, Lanzhou, China.

Objectives: To investigate the utility of spectral computed tomography (CT) parameters for the prediction of the preoperative Masaoka-Koga stage of thymic epithelial tumors (TETs).

Materials And Methods: Fifty-four patients with TETs, aged from 37 to 73 years old, an average age of 55.56 ± 9. Read More

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A rare case of multiple endocrine neoplasia type 1 initially presenting as an asymptomatic, huge mediastinal mass: case report.

BMC Endocr Disord 2021 Feb 25;21(1):31. Epub 2021 Feb 25.

Department of Endocrinology and Metabolism, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, 892 Dongnam-ro, Gangdong-gu, Seoul, 05278, Republic of Korea.

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited syndrome that concurrently involves various endocrine glands. We report a rare case of MEN1 in a 43-year-old man whose first manifestation was an asymptomatic mediastinal mass.

Case Presentation: A 13-cm-sized mediastinal mass was diagnosed as an atypical thymic carcinoid by computed tomography and percutaneous needle biopsy. Read More

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February 2021

Physiological Biodistribution of Ga-DOTA-TATE in Normal Subjects

Mol Imaging Radionucl Ther 2021 02;30(1):39-46

Marmara University Pendik Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey.

Objectives: Somatostatin is an endocrine peptide hormone that regulates neurotransmission and cell proliferation by interacting with G protein-coupled somatostatin receptors (SSTRs). SSTRs are specific molecular targets of several radiotracers for neuroendocrine tumor (NET) imaging. Gallium-68 (Ga)-DOTA-TATE is widely used for positron emission tomography/computed tomography (PET/CT) imaging of SSTRs and has shown a higher affinity for SSTR2, the most common SSTR subtype found in NETs. Read More

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February 2021

Prognostic Significance of Metabolic Parameters by F-FDG PET/CT in Thymic Epithelial Tumors.

Cancers (Basel) 2021 Feb 9;13(4). Epub 2021 Feb 9.

Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.

Background: Imaging tumor FDG avidity could complement prognostic implication in thymic epithelial tumors. We thus investigated the prognostic value of volume-based F-fluorodeoxyglucose (F-FDG) positron emission tomography (PET)/CT parameters in thymic epithelial tumors with other clinical prognostic factors.

Methods: This is a retrospective study that included 83 patients who were diagnosed with thymic epithelial tumors and underwent pretreatment F-FDG PET/CT. Read More

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February 2021

Thymic Hyperplasia with Lymphoepithelial Sialadenitis (LESA)-Like Features: Strong Association with Lymphomas and Non-Myasthenic Autoimmune Diseases.

Cancers (Basel) 2021 Jan 16;13(2). Epub 2021 Jan 16.

Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.

Thymic hyperplasia (TH) with lymphoepithelial sialadenitis (LESA)-like features (LESA-like TH) has been described as a tumor-like, benign proliferation of thymic epithelial cells and lymphoid follicles. We aimed to determine the frequency of lymphoma and autoimmunity in LESA-like TH and performed retrospective analysis of cases with LESA-like TH and/or thymic MALT-lymphoma. Among 36 patients (21 males) with LESA-like TH (age 52 years, 32-80; lesion diameter 7. Read More

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January 2021

How to obtain adequate biopsy specımen in suspected thymic tumors.

J Thorac Dis 2020 Dec;12(12):7598-7606

University of Health Sciences-Turkey, Izmir Dr. Suat Seren Training and Research Hospital for Thoracic Medicine and Surgery, Izmir, Turkey.

Pathologic diagnosis of thymic tumors (TTs) can be made by surgical or nonsurgical procedures. About 20% of TTs had been diagnosed by pretreatment biopsy methods while the rest had gone to surgery for diagnosis and treatment. However, in the last two decades there was an increase in pretreatment procedures for optimal management of locally advanced or metastatic TTs. Read More

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December 2020

The role of radiological imaging for masses in the prevascular mediastinum in clinical practice.

J Thorac Dis 2020 Dec;12(12):7591-7597

Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Tumors in the prevascular compartment of the mediastinum are rare and imaging plays a major role in their detection, (differential) diagnosis, staging, and follow-up. The prevascular compartment is bordered anteriorly by the posterior aspect of the sternum, posteriorly by the ventral aspect of the pericardium, cranially by the thoracic outlet, and caudally by the diaphragm. In many cases, the diagnosis of a lesion in the prevascular compartment is an incidental finding either on chest radiograph (CR) or on computed tomography (CT) scans. Read More

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December 2020

Administration of CD4CD25CD127FoxP3 Regulatory T Cells for Relapsing-Remitting Multiple Sclerosis: A Phase 1 Study.

BioDrugs 2021 Jan 5;35(1):47-60. Epub 2021 Jan 5.

Department of Medical Immunology, Medical University of Gdańsk, Debinki 7, 80-210, Gdańsk, Poland.

Background: Multiple sclerosis (MS) is an immune-mediated disease in which autoimmune T conventional (T) cells break the blood-brain barrier and destroy neurons of the central nervous system. It is hypothesized that CD4CD25CD127FoxP3 T regulatory (T) cells may inhibit this destruction through suppressive activity exerted on T cells.

Methods: We present the results of a phase 1b/2a, open-label, two-arm clinical trial in 14 patients treated with autologous T cells for relapsing-remitting MS. Read More

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January 2021