208,626 results match your criteria Thrombosed External Hemorrhoid Excision


Headache in Pregnancy, the Puerperium, and menopause.

Semin Neurol 2018 Dec 6;38(6):627-633. Epub 2018 Dec 6.

Department of Neurology, University at Buffalo School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, New York.

Headache is a neurologic disorder that displays gender dichotomy. It is well established that there is a strong link between migraine headache and sex hormones, specifically estrogen, which influences the severity of migraines during the menstrual cycle, pregnancy, and menopause. Furthermore, the epidemiology of headaches during pregnancy and the postpartum period is very distinct from that in males or nonpregnant females, in part due to the hemodynamic and hematologic changes that occur during pregnancy. Read More

View Article
December 2018
1 Read

Pulmonary embolectomy in a case of subacute pulmonary embolism, with previous unsuccessful fibrinolysis

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):418-423. Epub 2018 Nov 30.

Universidad Nacional Autónoma de México, Facultad de Medicina, División de Estudios de Posgrado. Ciudad de México, México

Background: Pulmonary embolism is a potentially fatal heart condition that requires prompt restoration of blood flow in the pulmonary vascular bed and prevention of recurrent events. Mortality is associated to the degree of hemodynamic repercussion, complications and opportunity in the treatment.

Case Report: Male 33 years of age who began with sudden dyspnea, chest pain of moderate intensity, sweating and syncope. Read More

View Article
November 2018

Recent developments in endovascular interventions to sustain vascular access patency in haemodialysis patients.

Nephrol Dial Transplant 2018 Dec 5. Epub 2018 Dec 5.

Department of Nephrology, Patras University Hospital, Patras, Greece.

There is amassed evidence regarding the use of endovascular procedures for the treatment of vascular access stenosis and thrombosis. A review was conducted based on available randomized trials, cohort studies and retrospective analyses published after 2000 on endovascular treatment of dysfunctional and thrombosed vascular access, with an aim to illustrate the available device and procedural options. The use of paclitaxel-coated balloons, cutting balloons and covered stents is described in the field of vascular access stenosis. Read More

View Article
December 2018

Prospective, randomized trial of bioresorbable scaffolds vs. everolimus-eluting stents in patients undergoing coronary stenting for myocardial infarction: the Intracoronary Scaffold Assessment a Randomized evaluation of Absorb in Myocardial Infarction (ISAR-Absorb MI) trial.

Eur Heart J 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiovascular Diseases, Deutsches Herzzentrum München, Technische Universität München, Lazarettstrasse 36, Munich, Germany.

Aims: Bioresorbable scaffolds (BRS) provide short-term coronary artery scaffolding and drug delivery. Although prior trials showed a higher rate of device failure compared with conventional drug-eluting stents (DES), only a single trial investigated patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction (MI). We aimed to compare outcomes with BRS vs. Read More

View Article
December 2018

Transient Q-waves in an infant with asymptomatic myocardial infarction due to Kawasaki disease.

Cardiol Young 2018 Dec 6:1-4. Epub 2018 Dec 6.

Department of Pediatrics,Shinshu University School of Medicine,Asahi 3-1-1, Matsumoto,Japan.

Giant coronary artery aneurysms are a complication of Kawasaki disease and can be fatal if associated with thrombosis. We describe the clinical outcome of a boy with Kawasaki disease who exhibited "supergiant" coronary artery aneurysms at the age of 14 months and, despite treatment with anticoagulant and antiplatelet medication, developed a left coronary artery thrombosis and presented following a myocardial infarction at 2 years old. Although his symptoms were minimal, the myocardial infarction was identified by abnormal Q-waves and giant negative T-waves in precordial leads of routine electrocardiography. Read More

View Article
December 2018

Investigation of the contribution of an underlying platelet defect in women with unexplained heavy menstrual bleeding.

Platelets 2018 Dec 6:1-9. Epub 2018 Dec 6.

b Institute of Cardiovascular Sciences, College of Medical and Dental Sciences , University of Birmingham , Birmingham , UK.

Heavy menstrual bleeding (HMB) is often undiagnosed in women and can cause discomfort and distress. A haemostatic cause for excessive bleeding is often not routinely investigated and can lead to hysterectomy at an early age. A prospective cohort study was carried out to determine whether certain patients with unexplained HMB have an underlying platelet function defect (PFD). Read More

View Article
December 2018
1 Read

Emergent surgical treatment of lethal valve dysfunction during pregnancy in a last-trimester patient.

Saudi Med J 2018 Dec;39(12):1249-1252

Department of Cardiovascular Surgery, Selcuk University, Konya, Turkey. E-mail.

A mechanical heart valve thrombosis during pregnancy is one of the most lethal conditions to experience due to its detrimental effects on both mother and fetus. Cardiac surgery during pregnancy is reserved for cases where medical treatment fails due to harmful maternal and fetal effects. A 24-year-old female in the 38th week of pregnancy was admitted to the emergency room with aggravated dyspnea, tachypnea, and palpitations. Read More

View Article
December 2018

Extensively thrombosed ectatic circumflex coronary artery fistula presenting as acute coronary syndrome.

Curr Cardiol Rev 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, University Heart Center, University Hospital Zurich. Switzerland.

Background: Coronary artery fistula (CAF) is an abnormal communication between the termination of a coronary artery or its branches and a cardiac chamber, a great vessel or other vascular structure. Symptomatic patients with large CAF should undergo surgical or percutanous closure of the fistula at the drainage site while still the debate on closing asymptomatic CAF and re-openening symptomatic occluded CAF is ongoing.

Case Summary: We are reporting a 30-year-old male patient with no previous medical history presented as non-ST segment elevation myocardial Infarction. Read More

View Article
December 2018

Prevalence of pharmacogenomic variants affecting the efficacy of clopidogrel therapy in the Hispanic Community Health Study/Study of Latinos cohort.

Pharmacogenomics 2018 Dec 6. Epub 2018 Dec 6.

Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Purpose: Although clopidogrel is the most widely used oral P2Y12 receptor antagonist, up to 10% of acute coronary syndrome patients treated with clopidogrel will experience a recurrent myocardial infarction and 2-3% will experience stent thrombosis within 1 year. The purpose of this research is to describe the prevalence of pharmacogene variants associated with clopidogrel responsiveness (CYP2C19, B4GALT2, ABCB1, PON1, CES1 and P2RY12) in Hispanic/Latino patients of diverse backgrounds.

Methods: Minor allele frequencies of nine variants from participants of Hispanic Community Health Study/Study of Latinos were compared between subpopulations as well as to continental ancestry references using z-test for independent proportions. Read More

View Article
December 2018
2 Reads

Outcomes following neonatal portal vein thrombosis: A descriptive, single-center study and review of anticoagulant therapy.

Pediatr Blood Cancer 2018 Dec 5:e27572. Epub 2018 Dec 5.

Division of Neonatology, Department of Pediatrics, McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada.

Background: Neonatal portal vein thrombosis (PVT) is uncommon with potentially serious complications that may manifest in infancy and childhood.

Objective: The primary aim of our study was to describe the short-term and long-term outcomes of neonatal PVT.

Methods: A retrospective chart review was conducted from 2008 to 2016 of neonates diagnosed with PVT. Read More

View Article
December 2018

The clinical impact of sex differences on ischemic postconditioning during primary percutaneous coronary intervention: a POST (the effects of postconditioning on myocardial reperfusion in patients with ST-segment elevation myocardial infarction) substudy.

Heart Vessels 2018 Dec 5. Epub 2018 Dec 5.

Kyungpook National University Hospital, Daegu, South Korea.

The POST (the effects of postconditioning on myocardial reperfusion in patients with ST-Segment elevation myocardial infarction) study showed that ischemic postconditioning did not improve myocardial reperfusion in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). However, it has not been determined whether postconditioning is effective in women. This study sought to evaluate the impact of sex differences on ischemic postconditioning during the primary PCI. Read More

View Article
December 2018

Surveillance Ultrasound in the Neuro Intensive Care Unit: Time to Deep Vein Thrombosis Diagnosis.

Neurocrit Care 2018 Dec 5. Epub 2018 Dec 5.

University Health System, San Antonio, TX, USA.

Background/objectives: Deep vein thrombosis (DVT) and pulmonary embolism (PE) are complications of hospitalization leading to increased morbidity and mortality. Routine surveillance ultrasound has become common practice in some intensive care units (ICU) to detect DVT early and initiate anticoagulation, preventing complications. However, initiating anticoagulants for asymptomatic DVT treatment may increase risk of hemorrhage. Read More

View Article
December 2018

Risk factors for potential pulmonary embolism in the patients with deep venous thrombosis: a retrospective study.

Eur J Trauma Emerg Surg 2018 Dec 5. Epub 2018 Dec 5.

Digital Subtraction Room, Tianjin Hospital, No. 406, south liberation road, Hexi district, Tianjin, 300211, China.

Introduction: The risk factors for the detachment of big thrombi from the vessel wall in patients with deep venous thrombosis (DVT) are still not clear, which are potential risks for pulmonary embolism (PE). This study was aimed to identify the risk factors for big thrombi detaching from the vessel wall in the patients with lower extremity DVT and to identify the role of the lower limb immobilization.

Methods: We retrospectively reviewed the patients whose inferior vena cava (IVC) filter were removed in our hospital. Read More

View Article
December 2018
1 Read

Direct Oral Anticoagulants and Travel-related Venous Thromboembolism.

Open Med (Wars) 2018 27;13:575-582. Epub 2018 Nov 27.

Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Ext 80252, Thailand.

Travel- related thromboembolism reflects the relationship between venous thromboembolism (VTE) and long-haul flights. Although this condition is rare, it may cause significant morbidity and mortality. Therefore, travelers should be evaluated for the risks for thrombosis. Read More

View Article
November 2018

1-(5-Bromo-2-hydroxy-4-methoxyphenyl)ethanone [SE1] Inhibits MMP-9 Expression by Regulating NF-κB and MAPKs Signaling Pathways in HT1080 Human Fibrosarcoma Cells.

Evid Based Complement Alternat Med 2018 5;2018:5639486. Epub 2018 Nov 5.

College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China.

Hippocampus is a traditional medicine in China, which can be used for treating tumors, aging, fatigue, thrombosis, inflammation, hypertension, prostatic hyperplasia, and other diseases. 1-(5-Bromo-2-hydroxy-4-methoxyphenyl)ethanone [SE1] from seahorse (a Bleeler) has been shown to suppress proinflammatory responses. In the present study, SE1 potently inhibited gelatin digestion by MMP-9 induced by phorbol 12-myristate 13-acetate (PMA) and migration of human fibrosarcoma HT1080 cells in dose-dependent manner. Read More

View Article
November 2018

Targeted Delivery of Bioactive Molecules for Vascular Intervention and Tissue Engineering.

Front Pharmacol 2018 21;9:1329. Epub 2018 Nov 21.

Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, United States.

Cardiovascular diseases are the leading cause of death in the United States. Treatment often requires surgical interventions to re-open occluded vessels, bypass severe occlusions, or stabilize aneurysms. Despite the short-term success of such interventions, many ultimately fail due to thrombosis or restenosis (following stent placement), or incomplete healing (such as after aneurysm coil placement). Read More

View Article
November 2018

Venous thrombosis and hormonal contraception: what's new with estradiol-based hormonal contraceptives?

Open Access J Contracept 2018 8;9:75-79. Epub 2018 Nov 8.

Institute of Obstetrics and Gynecology, Department of Medical Area, University of Udine, Udine, Italy.

Objective: Estradiol (E2)-based hormonal contraceptives impact less than ethinylstradiol (EE) contraceptives on venous thromboembolism (VTE) in comparison to formulations with EE.

Study Design: In this article, the pharamacologic data of EE and E2 were briefly reviewed, along with the induced biologic effect. These data were then related to a recent large international prospective, controlled, non-interventional cohort active surveillance study, on the cardiovascular risk of users of different types of combined estroprogestin contraceptive (CEPC). Read More

View Article
November 2018

Involving "authentic" cancer patients, their caregivers, and multidisciplinary professionals in a quality improvement trajectory in a hospital cancer pathway: a study protocol.

J Multidiscip Healthc 2018 9;11:661-671. Epub 2018 Nov 9.

Department of Internal Medicine, Zuyderland Medical Centre, Sittard, The Netherlands,

Introduction: The implementation of oncology care pathways that standardize organizational procedures has improved cancer care in recent years. However, the involvement of "authentic" patients and caregivers in quality improvement of these predetermined pathways is in its infancy, especially the scholarly reflection on this process. We, therefore, aim to explore the multidisciplinary challenges both in practice, when cancer patients, their caregivers, and a multidisciplinary team of professionals work together on quality improvement, as well as in our research team, in which a social scientist, health care professionals, health care researchers, and experience experts design a research project together. Read More

View Article
November 2018

Predictors of stent thrombosis and their implications for clinical practice.

Nat Rev Cardiol 2018 Dec 5. Epub 2018 Dec 5.

Kardiologie I, Zentrum für Kardiologie, University Medical Center Mainz and DZHK Standort Rhein-Main, Mainz, Germany.

Stent thrombosis (ST) is a rare but severe complication of coronary procedures with high mortality, high relapse rate and a very complex pathophysiology. An individual's susceptibility to ST is multifactorial and results from interactions between clinical factors, endothelial biology, hypersensitivity and/or inflammatory reactions, blood rheology, platelet reactivity, clotting factors, physical and mechanical properties of the stent and from the effects of these different factors on the fluid dynamics of blood flow. Since the introduction of stents 32 years ago, continuous improvements in our understanding of the pathophysiology of ST have triggered important advances, including new therapies, new technologies and an increased awareness of the implications of implantation techniques. Read More

View Article
December 2018

Risk Profile and 1-Year Outcome of Newly Diagnosed Atrial Fibrillation in Japan - Insights From GARFIELD-AF.

Circ J 2018 Dec 4. Epub 2018 Dec 4.

Thrombosis Research Institute.

Background: Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective non-interventional study of stroke prevention in patients with newly diagnosed non-valvular AF (NAVF) that is being conducted in 35 countries. Methods and Results: A total of 52,081 patients with a new diagnosis of NVAF were enrolled prospectively in GARFIELD-AF. Of these, 4859 (9. Read More

View Article
December 2018

Involvement of Apelin/APJ Axis in Thrombogenesis in Valve Heart Disease Patients with Atrial Fibrillation.

Int Heart J 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University.

The mechanism underlying thrombosis in atrial fibrillation (AF) is not yet clearly understood. The apelin/APJ axis parallel and counter-regulate with the angiotensin system. The present study hypothesizes that apelin/APJ axis exert its anti-thrombus effect in normal left atrial tissue and is disrupted by up-regulated renin-angiotensin-aldosterone system (RAAS) signaling during AF. Read More

View Article
December 2018

Assessment of in vitro effects of direct thrombin inhibitors and activated factor X inhibitors through clot waveform analysis.

J Clin Pathol 2018 Dec 5. Epub 2018 Dec 5.

Department of Laboratory Medicine, Keio University School of Medicine, Tokyo, Japan.

Aims: Clot waveform analysis (CWA) has been reported to extend the interpretation of clotting time measurement. The parameters obtained from successive derivatives of the clotting reaction curves reflect the rates of activation of individual coagulation factors, theoretically dissecting the cascade pathway. This study aims to assess the in vitro effects of direct thrombin inhibitors (DTIs) and activated factor X (FXa) inhibitors. Read More

View Article
December 2018

Prognostic accuracy of different disseminated intravascular coagulation criteria in critically ill adult patients: a protocol for a systematic review and meta-analysis.

BMJ Open 2018 Dec 4;8(12):e024878. Epub 2018 Dec 4.

Division of Trauma and Surgical Critical Care, Osaka General Medical Center, Osaka, Japan.

Introduction: Disseminated intravascular coagulation (DIC) is a common and serious condition that can lead to poor outcomes in critically ill patients. To make a correct diagnosis and improve the outcome of patients with DIC, several organisations have put forward DIC scoring systems. However, which criteria is the best to use for diagnosing DIC remains a continuing controversy even though many studies have been conducted to validate the diagnostic accuracy of each DIC scoring system. Read More

View Article
December 2018
1 Read

The Efficacy of IV Tissue Plasminogen Activator for Restoring Cerebral Blood Flow in the Hours Immediately after Administration in Patients with Acute Stroke.

J Neuroimaging 2018 Dec 3. Epub 2018 Dec 3.

National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.

Background And Purpose: Timely restoration of tissue-level cerebral blood flow is the goal of thrombolytic therapy in patients presenting with an acute ischemic stroke. We aimed to identify the incidence and predictors of reperfusion immediately following treatment with intravenous recombinant tissue plasminogen activator (IV rt-PA).

Methods: This study included patients with acute ischemic stroke triaged using magnetic resonance imaging (MRI) with perfusion-weighted imaging (PWI) and treated with IV rt-PA who were subsequently enrolled in our natural history study and underwent repeat MRI with PWI approximately 2 hours posttreatment. Read More

View Article
December 2018

Efficacy of dual antiplatelet therapy for preventing recurrence of arterial thrombosis in patients with antiphospholipid syndrome.

Rheumatology (Oxford) 2018 Nov 30. Epub 2018 Nov 30.

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Objective: Warfarin is regarded as the standard treatment for preventing thrombotic events in APS, but the recurrence rate is still high. Dual antiplatelet therapy (DAPT) has been shown to be effective for the prevention of acute coronary syndrome or stroke. The objective of this study was to evaluate the efficacy of DAPT for the prevention of thrombosis recurrence in APS patients with history of arterial thrombosis. Read More

View Article
November 2018

Utility of Cement Augmentation via Percutaneous Fenestrated Pedicle Screws for Stabilization of Cancer Related Spinal Instability.

Oper Neurosurg (Hagerstown) 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: Cancer patients experience pathological fractures and the typical poor bone quality frequently complicates stabilization. Methods for overcoming screw failure include utilization of fenestrated screws that permit the injection of bone cement into the vertebral body to augment fixation.

Objective: To evaluate the safety and efficacy of cement augmentation via fenestrated screws. Read More

View Article
December 2018

What Causes LVAD-Associated Ischemic Stroke? Surgery, Pump Thrombosis, Antithrombotics, and Infectionsa.

ASAIO J 2018 Nov 28. Epub 2018 Nov 28.

Cerebrovascular Center of the Neurological Institute, Cleveland Clinic, Cleveland, Ohio.

Acute ischemic stroke (AIS) is a major complication in left ventricular assist device (LVAD) population. A better understanding of clinical risk factors associated with AIS may help mitigate risk of stroke. We reviewed prospectively collected data of 477 LVAD patients from a tertiary center from October 1, 2004 to December 31, 2016. Read More

View Article
November 2018

Prospective Evaluation of a Rapid Functional Assay for Heparin-Induced Thrombocytopenia Diagnosis in Critically Ill Patients.

Crit Care Med 2018 Nov 30. Epub 2018 Nov 30.

Division of Hematology Laboratory, Thrombosis and Hemostasis Center, Tenon Hospital, APHP.6, Sorbonne Université, HUEP Paris, France.

Objectives: Overdiagnosis of heparin-induced thrombocytopenia remains an unresolved issue in the ICU leading to the unjustified switch from heparin to alternative anticoagulants or delays in anticoagulation. Platelet function assays significantly improve the specificity of heparin-induced thrombocytopenia diagnosis, but they are not readily available, involve technical difficulties and have a long turnaround time. We evaluated the performance of a rapid and easy to perform functional assay for heparin-induced thrombocytopenia diagnosis in ICU patients, known as "heparin-induced multiple electrode aggregometry. Read More

View Article
November 2018

Relationship between sex hormone binding globulin and blood coagulation in women on postmenopausal hormone treatment.

Blood Coagul Fibrinolysis 2018 Nov 29. Epub 2018 Nov 29.

Department of Haematology.

: Postmenopausal hormone therapy increases the risk of venous thrombosis. Sex hormone binding globulin (SHBG) is a suggested marker of 'total estrogenicity'. The study objective was to evaluate the impact of hormone therapy on SHBG and the association with coagulation variables. Read More

View Article
November 2018

Genotype analysis and identification of novel mutations in a multicentre cohort of patients with hereditary factor X deficiency.

Blood Coagul Fibrinolysis 2018 Nov 29. Epub 2018 Nov 29.

St. George's Haemophilia Centre, St. George's University Hospitals NHS Foundation Trust, London, UK.

: The objective was to examine the genotypic and phenotypic characteristics of individuals with hereditary factor X deficiency (FXD), a rare autosomal recessive bleeding disorder caused by mutations in the F10 gene located on chromosome 13q34-ter. To date, 149 F10 mutations have been identified as contributory to FXD. Three open-label phase 3 trials enrolled individuals with mild, moderate, or severe FXD. Read More

View Article
November 2018

Comparison of Resolute zotarolimus-eluting and Xience everolimus-eluting stents in patients with de novo long coronary artery lesions: a randomized LONG-DES VI trial.

Coron Artery Dis 2018 Nov 29. Epub 2018 Nov 29.

Asan Medical Center, Heart Institute, University of Ulsan College of Medicine.

Background: Outcomes for stent-based coronary intervention of lesions with long diseased segments remain relatively unfavorable. This study sought to compare the efficacy of Resolute zotarolimus-eluting stents (R-ZES) and Xience everolimus-eluting stents (EES) for very long coronary lesions.

Methods And Results: This randomized, multicenter, prospective trial compared the use of R-ZES with EES for very long (≥50 mm) native coronary lesions. Read More

View Article
November 2018

Comparison of treatments for persistent/chronic immune thrombocytopenia: a systematic review and network meta-analysis.

Platelets 2018 Dec 3:1-11. Epub 2018 Dec 3.

a Department of Hematology and Oncology , Graduate School of Medicine, Kyoto University , Kyoto , Japan.

Recent studies have indicated that medical options without splenectomy, such as rituximab (RTX) or thrombopoietin receptor agonists (TPO-RAs), can be effective to treat persistent or chronic primary immune thrombocytopenia (ITP). However, it remains to be determined which of these strategies should be the first choice after the first-line treatment for newly diagnosed ITP. We performed a systematic review and network meta-analysis to establish a clinically meaningful hierarchy of the efficacy and safety of medical treatments for persistent or chronic ITP in adults. Read More

View Article
December 2018
2 Reads

In-hospital outcomes of transcatheter mitral valve repair with Mitraclip in patients with pulmonary hypertension: Insights from the National Inpatient Sample.

Catheter Cardiovasc Interv 2018 Dec 2. Epub 2018 Dec 2.

Department of Cardiovascular Medicine, Wayne State University/Detroit Medical Center, Detroit, Michigan.

Background: Periprocedural outcomes of transcatheter mitral valve repair (TMVR) with Mitraclip in patients with pulmonary hypertension (PH) are not well studied.

Methods: Patients who underwent TMVR with Mitraclip between 2011 and 2015 were identified using the National Inpatient Sample (NIS). All missing variables were excluded from the analysis and therefore, complete case analysis was performed. Read More

View Article
December 2018

Extracellular traps derived from macrophages, mast cells, eosinophils and neutrophils are generated in a time-dependent manner during atherothrombosis.

J Pathol 2018 Dec 2. Epub 2018 Dec 2.

Department of Pathology, Amsterdam UMC, University of Amsterdam, Netherlands.

Extracellular traps generated by neutrophils contribute to thrombus progression in coronary atherosclerotic plaques. It is not known whether other inflammatory cell types in coronary atherosclerotic plaque or thrombus also release extracellular traps. We investigated their formation by macrophages, mast cells and eosinophils in human coronary atherosclerosis, and in relation to the age of thrombus of myocardial infarction patients. Read More

View Article
December 2018

The last post.

J Thromb Haemost 2018 Dec;16(12):2357

Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands.

View Article
December 2018
1 Read

Liver stiffness in non-cirrhotic portal hypertension - The Devil is in the diagnosis.

Hepatology 2018 Dec 1. Epub 2018 Dec 1.

Dept. of Clinical Medicine, "Sapienza" University of Rome, Rome, Italy.

We have read with great interest the article by Vuppalanchi et al. , who studied the diagnostic role of liver stiffness measurements (LSM) in patients with non-cirrhotic portal hypertension (NCPH) due to hepatic (nodular regenerative hyperplasia-NRH) or prehepatic origin (portal vein thrombosis-PVT). The role of LSM to identify a cirrhosis as the cause of the portal hypertension is well established and the evidence of PVT in any imaging technique is sufficient to attribute the cause of portal hypertension to PVT and does not require further histological or elastographical confirmation. Read More

View Article
December 2018
1 Read

Valve durability after transcatheter aortic valve implantation.

J Thorac Dis 2018 Nov;10(Suppl 30):S3629-S3636

Division of Cardiology, University of Washington, Seattle, WA, USA.

Transcatheter aortic valve implantation (TAVI) is a minimally invasive procedure to treat severe symptomatic aortic stenosis. While the TAVI procedure can be performed safely and provide excellent 5-year results, little is known about long-term durability. TAVI valves are composed of bioprosthetic leaflets are prone to deterioration, which are categorized as structural valve deterioration (SVD) and non-SVD. Read More

View Article
November 2018

Transcatheter valve-in-valve implantation for degenerated surgical bioprostheses.

J Thorac Dis 2018 Nov;10(Suppl 30):S3573-S3577

Centre for Heart Valve Innovation, St. Paul's Hospital, Vancouver, Canada.

Transcatheter valve-in-valve (VIV) procedures are less invasive than re-do open heart surgery, and have proven relatively safe and effective. In large multicentre registries morbidity and mortality risks are generally lower than with surgery, and improvement in quality of life can be profound. Outcomes continue to improve with advances in transcatheter heart valve (THV) technology, techniques, and expertise. Read More

View Article
November 2018

Particulate Matter Air Pollution: Effects on the Cardiovascular System.

Front Endocrinol (Lausanne) 2018 16;9:680. Epub 2018 Nov 16.

Section of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Chicago, Chicago, IL, United States.

Air pollution is a complex mixture of gaseous and particulate components, each of which has detrimental effects on human health. While the composition of air pollution varies greatly depending on the source, studies from across the world have consistently shown that air pollution is an important modifiable risk factor for significantly increased morbidity and mortality. Moreover, clinical studies have generally shown a greater impact of particulate matter (PM) air pollution on health than the gaseous components. Read More

View Article
November 2018

Concomitant left main coronary artery and prosthetic mitral valve thrombosis treatment.

Authors:
Ayhan Olcay

Anatol J Cardiol 2018 Dec;20(6):365-367

Department of Cardiology, Faculty of Medicine, İstanbul Aydın University; İstanbul-Turkey.

View Article
December 2018

Pericallosal lipoma masquerading as venous thrombosis on magnetic resonance imaging.

Neurol India 2018 Nov-Dec;66(6):1846-1847

Department of Neurology, Yashoda Superspeciality Hospital, Malakpet, Hyderabad, Telangana, India.

View Article
December 2018

Status epilepticus related to pregnancy: Devising a protocol for use in the intensive care unit.

Neurol India 2018 Nov-Dec;66(6):1629-1633

Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.

Background: Status epilepticus (SE) related to pregnancy is rare and carries a significant risk to both the mother and the fetus.

Objectives: We conducted this study to devise a protocol for the management of SE related to pregnancy in a cohort of female patients admitted with SE during pregnancy.

Materials And Methods: All women who developed SE related to pregnancy (gestation, labor, and puerperium) between January 2000 and December 2016 were included. Read More

View Article
December 2018

An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1.

Blood 2018 Dec 1. Epub 2018 Dec 1.

Department of Physiology and Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, United States

Tissue-type plasminogen activator (tPA) is a major mediator of fibrinolysis and thereby prevents excessive coagulation without compromising hemostasis. Studies on tPA regulation have focused on its acute, local release by vascular cells in response to injury or other stimuli. However, very little is known about sources, regulation, and fibrinolytic function of non-injury-induced systemic plasma tPA. Read More

View Article
December 2018

Adult and pediatric mechanical circulation: a guide for the hematologist.

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):507-515

Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

Mechanical circulatory support (MCS) is the overarching term that encompasses the temporary and durable devices used in patients with severe heart failure. MCS disturbs the hematologic and coagulation system, leading to platelet activation, activation of the contact pathway of coagulation, and acquired von Willebrand syndrome. Ischemic stroke and major hemorrhage occur in up to 30% of patients. Read More

View Article
November 2018

Elite athletes and anticoagulant therapy: an intermittent dosing strategy.

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):412-417

Primary Care Sports Medicine, Baylor Scott & White Health, Waco, TX; and.

Traditionally, the athlete who requires long-term anticoagulation has been told to forgo participation in contact and collision sports. However, a strategy of short-term interruption of anticoagulant therapy may be designed for some athletes, allowing them return to full athletic activity. A personalized pharmacokinetic/pharmacodynamic study of a direct oral anticoagulant (DOAC) may allow athletic participation when plasma drug concentration is minimal and resumption of treatment after the risk of bleeding sufficiently normalizes. Read More

View Article
November 2018

Management of thrombosis in children and neonates: practical use of anticoagulants in children.

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):399-404

Department of Clinical Haematology, Royal Children's Hospital, Haematology Research Murdoch Children's Research Institute, School of Nursing, University of Melbourne, Melbourne, VIC, Australia.

Venous thrombosis (VTE) in children and neonates presents numerous management challenges. Although increasing in frequency, VTE in children and neonates is still uncommon compared with adults. The epidemiology of VTE is vastly different in neonates vs children vs adolescents vs adults. Read More

View Article
November 2018

Inherited hemolytic anemia: a possessive beginner's guide.

Authors:
Narla Mohandas

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):377-381

New York Blood Center, New York, NY.

Significant advances have been made in diagnosis and clinical management of inherited red cell membrane disorders that result in hemolytic anemia. Membrane structural defects lead to hereditary spherocytosis (HS) and hereditary elliptocytosis (HE), whereas altered membrane transport function accounts for hereditary xerocytosis (HX) and hereditary overhydrated stomatocytosis (OHS). The degrees of membrane loss and resultant increases in cell sphericity determine the severity of anemia in HS and HE, and splenectomy leads to amelioration of anemia by increasing the circulatory red cell life span. Read More

View Article
November 2018

Optimizing quality care for the oral vitamin K antagonists (VKAs).

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):332-338

Cardiology Clinic, Thrombosis Centre, University of Padua, Padua, Italy.

Vitamin K antagonists (VKAs) have been the only oral anticoagulants for decades. The management of anticoagulant therapy with VKA is challenging because of the intricate pharmacological properties of these agents. The success of VKA therapy depends on the quality of treatment that is ensured through continuing comprehensive communication and education. Read More

View Article
November 2018