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West Afr J Med 2022 Apr;39(4):425-428

Department of Surgery, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu State, Nigeria.

Background: Mondor's disease (MD) is a rare cause of chest pain, characterized by thrombophlebitis of the subcutaneous veins of the anterolateral thoracoabdominal wall. It is a benign, self-limiting condition that is often underdiagnosed due to lack of knowledge of the condition. Although the exact aetiology is unclear, several predisposing factors, including excessive physical activity have been postulated. Read More

J Dermatol 2022 Apr 17. Epub 2022 Apr 17.

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.

Behçet's disease (BD) has a heterogeneous spectrum of disease manifestations featuring the involvement of different organs and can be characterized with different symptoms depending on the clinical department in charge. We retrospectively reviewed BD patients seen at our hospital and investigated the presence of neutrophils producing neutrophil extracellular traps (NET) in those patients. Immunolabeling of myeloperoxidase and histone citrullination proteins was performed on skin biopsies from three BD patients who had skin biopsy-proven superficial vein thrombophlebitis in their erythema nodosum-like lesions. Read More

BMC Urol 2022 Apr 12;22(1):57. Epub 2022 Apr 12.

Morphological Sciences Department, Institute of Medical Sciences, Medical College of Rzeszow University, Leszka Czarnego 4, 35-301, Rzeszow, Poland.

Background: Penile Mondor disease is a superficial dorsal vein thrombophlebitis of the penis, which mainly affects young and middle-aged men. It generally manifests as a visible painful cord located along the dorsal surface of the penis with signs of skin inflammation. The condition is usually self-limiting, but in severe cases a surgical procedure may be necessary in addition to pharmacological treatment. Read More

Eur J Case Rep Intern Med 2022 23;9(3):003258. Epub 2022 Mar 23.

Urology Department, Royal Hobart Hospital, Hobart, Tasmania, Australia.

Penile Mondor's disease is a rare condition characterised by superficial thrombophlebitis of the penis which is usually self-limiting. The cause is often unknown. The AstraZeneca ChAdOx1-S vaccine has been found to cause a hypercoagulable state, which is well documented. Read More

JAMA Surg 2022 May;157(5):395-404

Department of Surgery and Cancer, Imperial College London, London, United Kingdom.

Importance: Endovenous thermal ablations (ETAs) are recommended as first-line treatment for truncal vein reflux, have a short recovery time, and are cost-effective. However, ETAs are associated with discomfort during tumescent anesthesia infiltration. To minimize discomfort, nonthermal, nontumescent ablation techniques had emerged in the form of mechanochemical ablation (MOCA) and cyanoacrylate adhesive injection (CAE). Read More

Cureus 2022 Feb 17;14(2):e22320. Epub 2022 Feb 17.

Obstetrics and Gynecology, All India Institute of Medical Sciences, Gorakhpur, Gorakhpur, IND.

Mondor's disease is an uncommon cause of breast and chest pain. It is characterized by cord-like thickening of the superficial veins of the anterior chest wall mimicking many life-threatening illnesses such as pulmonary thromboembolism and myocardial infarction. The disease may have been caused by trauma, other hypercoagulable states, or underlying breast diseases such as infection or carcinoma breast, but, in most cases, its etiology remains unknown. Read More

Sex Med Rev 2022 Mar 3. Epub 2022 Mar 3.

Department of Urology, Acibadem Mehmet Ali Aydınlar University, School of Medicine, İstanbul, Turkey.

Introduction: Penile Mondor's Disease (PMD) is a rare illness that causes thrombophlebitis in the superficial veins of the penis that is manifested by transient pain and swelling. PMD often is associated with trauma to the penis, prolonged or vigorous sexual intercourse, and has been linked to genetics.

Objectives: Our aim is to review the current literature on PMD. Read More

Nanoscale 2022 Mar 7;14(9):3545-3553. Epub 2022 Mar 7.

GBA National Institute for Nanotechnology Innovation, Guangzhou, Guangdong 510700, P.R. China.

Superficial thrombophlebitis is one of the most significant complications of superficial vein thrombosis. Rapid imaging and mapping with high resolution is particularly important for accurate diagnosis so as to carry out treatment as soon as possible. Ultrasound imaging technology has been used extensively because of the low-cost, minimal invasiveness, and convenient application in clinical practice. Read More

Cureus 2021 Dec 25;13(12):e20690. Epub 2021 Dec 25.

Medicine, King Fahad Medical City, Riyadh, SAU.

Deep venous thrombosis (DVT) is the most common cause of unilateral lower limb swelling. Common differential diagnosis includes superficial thrombophlebitis and ruptured Baker's cyst. DVT is one of the most common complications diagnosed following lower extremity orthopedic surgery. Read More

Cureus 2021 Dec 21;13(12):e20580. Epub 2021 Dec 21.

Urology, University of Iowa, Iowa City, USA.

Varicocele is a common condition, estimated to be present in 15% of the general male population. It consists of abnormal dilation and tortuosity of the internal spermatic veins within the pampiniform plexus of the spermatic cord. In adults, varicocele repair may be considered in cases of scrotal pain, or of infertility associated with impaired sperm parameters. Read More

Rev Int Androl 2022 Jan 22. Epub 2022 Jan 22.

Urologist, Clínica Reina Sofía, Bogotá, Colombia.

The thrombophlebitis of the superficial dorsal vein of the penis, called Mondor's penile disease (PMD), is a condition with a low incidence worldwide. In general, it is considered a self-limited disease that usually resolves with conservative management and very rarely requires surgical intervention. We report the case of a 41-year-old patient, who presented PMD which persists after medical treatment with nonsteroidal antiinflammatory drug and low molecular weight heparin. Read More

Int J Low Extrem Wounds 2021 Dec 27:15347346211070669. Epub 2021 Dec 27.

34753West China Hospital, Chengdu, Sichuan Province, China.

Dermatol Surg 2022 Jan;48(1):72-75

Both authors are affiliated with the Department of Dermatology, Dr. Ram Manohar Lohia Hospital and ABVIMS, New Delhi, India.

Background: Polidocanol is a safe sclerosing agent with anesthetic properties and minimal skin toxicity.

Objective: To evaluate the efficacy, safety, and recurrence rates with polidocanol sclerotherapy in the treatment of pyogenic granulomas (PGs).

Methods And Methods: Thirty-nine patients with PG were injected with polidocanol 1% solution. Read More

Reumatol Clin (Engl Ed) 2021 Nov;17(9):514-520

Rheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address:

Introduction: Behçet's disease (BD) is a systemic inflammatory disease with various presentations. The data on the course of BD in Egyptian patients are limited.

Objectives: The objective of the study was to describe the evolution and association of the different phenotypes of BD. Read More

Clin Case Rep 2021 Oct 23;9(10):e04987. Epub 2021 Oct 23.

Department of Respiratory Medicine Hitachi General Hospital Hitachi, Ltd Hitachi Japan.

A local hypercoagulable state caused by SARS-CoV-2 and an indwelling peripheral venous catheter can lead to superficial thrombophlebitis. If the venous catheter is no longer needed during treatment for COVID-19 it should be removed promptly. Read More

Ann Vasc Surg 2022 Feb 11;79:335-347. Epub 2021 Oct 11.

Department of General Surgery, Qilu Hospital, Shandong University, Jinan, China.. Electronic address:

Background: Superficial thrombophlebitis (ST) is a frequent pathology, but its exact incidence remains to be determined. This study tested the hypothesis whether relationships exist among smooth muscle cells (SMCs) derived from ST, varicose great saphenous veins (VGSVs), and normal great saphenous veins (GSVs).

Methods: Forty-one samples of ST, VGSVs, and GSVs were collected. Read More

JAMA Netw Open 2021 10 1;4(10):e2127836. Epub 2021 Oct 1.

Beaumont Hospital, Royal Oak, Michigan.

Importance: Data regarding upper extremity midline catheter (MC)-related thrombosis (CRT) are sparse, with some evidence indicating that MCs have a high rate of CRT.

Objective: To compare 2 MCs with differing antithrombogenic mechanisms for this outcome.

Design, Setting, And Participants: In this parallel, 2-arm randomized clinical trial, 496 adult patients hospitalized at a tertiary care suburban academic medical center who received an MC were assessed for eligibility between January 1, 2019, and October 31, 2020, and 212 were randomized. Read More

Joint Bone Spine 2022 03 15;89(2):105277. Epub 2021 Sep 15.

Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey.

Objectives: To describe demographic and clinical characteristics of vascular involvement in patients with Behçet's syndrome (BS) and to evaluate associations with such involvement.

Methods: We retrospectively evaluated records of 2118 BS patients. In total, 460 patients diagnosed with superficial thrombophlebitis (ST) and/or major vascular events (venous and/or arterial involvements) were included in current analysis. Read More

Diagn Progn Res 2021 Aug 18;5(1):15. Epub 2021 Aug 18.

Dept. General Practice, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

Background: Superficial venous thrombosis (SVT) is considered a benign thrombotic condition in most patients. However, it also can cause serious complications, such as clot progression to deep venous thrombosis (DVT) and pulmonary embolism (PE). Although most SVT patients are encountered in primary healthcare, studies on SVT nearly all were focused on patients seen in the hospital setting. Read More

J Vasc Surg Cases Innov Tech 2021 Sep 1;7(3):496-501. Epub 2021 Jul 1.

Division of Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham, Ala.

In the present case report, we have described concomitant, rapidly expanding, abdominal and thoracic mycotic aortic pseudoaneurysms in a patient who had originally presented for right arm superficial thrombophlebitis and a right-hand abscess in the presence of methicillin sensitive bacteremia. Within 12 days, the patient had developed a rapidly expanding paravisceral mycotic abdominal aortic pseudoaneurysm that required open surgical repair. After the initial operation, she developed a thoracic mycotic aortic aneurysm that ultimately required open surgical repair. Read More

J Anaesthesiol Clin Pharmacol 2021 Apr-Jun;37(2):307-309. Epub 2021 Jul 15.

Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Afr J Urol 2021 6;27(1):97. Epub 2021 Jul 6.

Department of Cardiology, Acıbadem Healthcare Group, Acibadem Hospital, Tekin Sk. No:8, 34718 Kadıköy/İstanbul, Turkey.

Background: Penile Mondor's disease (PMD) is thrombophlebitis of the superficial dorsal vein of the penis. Following the occurrence of thrombotic events in the affected veins, the lumen often becomes occluded with fibrin and inflammatory cells. A hyper-coagulative state is one of the underlying causes although most cases of PMD are idiopathic. Read More

Semin Thromb Hemost 2021 May 10. Epub 2021 May 10.

Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Isolated distal deep vein thrombosis (IDDVT) is presumed to be more benign than proximal DVT (PDVT) or pulmonary embolism (PE), suggesting a need for different management approaches. This subgroup analysis of the RE-COVERY DVT/PE global, observational study investigated patient characteristics, hospitalization details, and anticoagulant therapy in patients with IDDVT in real-world settings in 34 countries enrolled from January 2016 to May 2017. Data were analyzed descriptively according to the type and location of the index venous thromboembolism (VTE): IDDVT, PDVT ± distal DVT (DDVT), and PE ± DVT. Read More

Vasc Med 2021 08 8;26(4):409-414. Epub 2021 Apr 8.

Clinic of Angiology, University Hospital Zurich, Zurich, Switzerland.

Mondor disease is characterized by an acute painful thrombophlebitis occurring at specific anatomical sites. Data on its incidence, characteristics of clinical presentation, and course are unavailable to date. We studied the course of Mondor disease in patients diagnosed and followed at the University Hospital Zurich (Switzerland) between 2004 and 2020. Read More

J Med Case Rep 2021 Apr 2;15(1):188. Epub 2021 Apr 2.

Surgery Department, Mohamed Taher El Maamouri Hospital, Nabeul, Tunisia.

Background: Mondor's disease of the breast (MDB) is a rare and benign disorder of the breast. It is characterized by thrombophlebitis of the superficial veins of the chest wall. Clinically, it manifests as a cord-like induration of the breast area. Read More

Cureus 2021 Feb 18;13(2):e13421. Epub 2021 Feb 18.

Breast Surgery, West Hertfordshire Hospitals NHS Trust, St. Albans, GBR.

Mondor's disease is a rare, peculiar form of superficial thrombophlebitis which mainly affects the subcutaneous veins of the breast, anterior chest wall, neck, axilla, upper limbs and penis. In most cases, it presents with rapid development of a painful subcutaneous cord-like structure that later becomes less painful, but a fibrous band persists. Unfortunately, aetiology and management are not very clear, but it is a self-limiting condition in most cases. Read More

Plast Reconstr Surg Glob Open 2021 Mar 15;9(3):e3459. Epub 2021 Mar 15.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Rutgers-New Jersey Medical School, Newark, N.J.

Chest masculinization for gender affirmation is the removal of breast tissue and excess skin, often with repositioning of the nipple areola complexes to achieve a male-appearing chest. A double-incision technique with free nipple grafting (FNG) is the preferred method for trans men with large, ptotic breasts. The authors present the outcomes of 72 consecutive chest masculinization cases using this technique. Read More

Stem Cells Int 2021 23;2021:8816763. Epub 2021 Feb 23.

Department of Vascular Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Background: Vascular adventitia contains progenitor cells and is shown to participate in vascular remolding. Progenitor cells are recruited into the venous thrombi in mice to promote neovascularization. We hypothesized that the adventitial progenitor cells of human great saphenous vein (HGSV-AdPC) enhance the resolution of venous thrombosis via neovascularization. Read More

Oxf Med Case Reports 2021 Feb 15;2021(2):omaa143. Epub 2021 Feb 15.

PGY-3, Dayton Children's Hospital, Dayton, OH, USA.

We report a case of a 14-month-old boy with atopic dermatitis (AD) who presented to our hospital with hypocalcemic tetany and gross motor delay. Further laboratory and imaging confirmed the diagnosis of vitamin D deficiency and rickets. He was breastfeeding and on a restricted diet due to presumed multiple food allergies. Read More

Int J Cardiol 2021 05 30;331:221-229. Epub 2021 Jan 30.

Clinical Department of Medical, Surgical and Health Science, University of Trieste, Piazzale Europa, 1, 34127 Trieste, TS, Italy.

Background: Hughes-Stovin syndrome (HSS) is a systemic disease characterized by widespread vascular thrombosis and pulmonary vasculitis with serious morbidity and mortality. The HSS International Study Group is a multidisciplinary taskforce aiming to study HSS, in order to generate consensus recommendations regarding diagnosis and treatment.

Methods: We included 57 published cases of HSS (43 males) and collected data regarding: clinical presentation, associated complications, hemoptysis severity, laboratory and computed tomography pulmonary angiography (CTPA) findings, treatment modalities and cause of death. Read More