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Semin Thromb Hemost 2021 May 10. Epub 2021 May 10.

Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Isolated distal deep vein thrombosis (IDDVT) is presumed to be more benign than proximal DVT (PDVT) or pulmonary embolism (PE), suggesting a need for different management approaches. This subgroup analysis of the RE-COVERY DVT/PE global, observational study investigated patient characteristics, hospitalization details, and anticoagulant therapy in patients with IDDVT in real-world settings in 34 countries enrolled from January 2016 to May 2017. Data were analyzed descriptively according to the type and location of the index venous thromboembolism (VTE): IDDVT, PDVT ± distal DVT (DDVT), and PE ± DVT. Read More

Vasc Med 2021 Apr 8:1358863X211000420. Epub 2021 Apr 8.

Clinic of Angiology, University Hospital Zurich, Zurich, Switzerland.

Mondor disease is characterized by an acute painful thrombophlebitis occurring at specific anatomical sites. Data on its incidence, characteristics of clinical presentation, and course are unavailable to date. We studied the course of Mondor disease in patients diagnosed and followed at the University Hospital Zurich (Switzerland) between 2004 and 2020. Read More

J Med Case Rep 2021 Apr 2;15(1):188. Epub 2021 Apr 2.

Surgery Department, Mohamed Taher El Maamouri Hospital, Nabeul, Tunisia.

Background: Mondor's disease of the breast (MDB) is a rare and benign disorder of the breast. It is characterized by thrombophlebitis of the superficial veins of the chest wall. Clinically, it manifests as a cord-like induration of the breast area. Read More

Cureus 2021 Feb 18;13(2):e13421. Epub 2021 Feb 18.

Breast Surgery, West Hertfordshire Hospitals NHS Trust, St. Albans, GBR.

Mondor's disease is a rare, peculiar form of superficial thrombophlebitis which mainly affects the subcutaneous veins of the breast, anterior chest wall, neck, axilla, upper limbs and penis. In most cases, it presents with rapid development of a painful subcutaneous cord-like structure that later becomes less painful, but a fibrous band persists. Unfortunately, aetiology and management are not very clear, but it is a self-limiting condition in most cases. Read More

Plast Reconstr Surg Glob Open 2021 Mar 15;9(3):e3459. Epub 2021 Mar 15.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Rutgers-New Jersey Medical School, Newark, N.J.

Chest masculinization for gender affirmation is the removal of breast tissue and excess skin, often with repositioning of the nipple areola complexes to achieve a male-appearing chest. A double-incision technique with free nipple grafting (FNG) is the preferred method for trans men with large, ptotic breasts. The authors present the outcomes of 72 consecutive chest masculinization cases using this technique. Read More

Stem Cells Int 2021 23;2021:8816763. Epub 2021 Feb 23.

Department of Vascular Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Background: Vascular adventitia contains progenitor cells and is shown to participate in vascular remolding. Progenitor cells are recruited into the venous thrombi in mice to promote neovascularization. We hypothesized that the adventitial progenitor cells of human great saphenous vein (HGSV-AdPC) enhance the resolution of venous thrombosis via neovascularization. Read More

Oxf Med Case Reports 2021 Feb 15;2021(2):omaa143. Epub 2021 Feb 15.

PGY-3, Dayton Children's Hospital, Dayton, OH, USA.

We report a case of a 14-month-old boy with atopic dermatitis (AD) who presented to our hospital with hypocalcemic tetany and gross motor delay. Further laboratory and imaging confirmed the diagnosis of vitamin D deficiency and rickets. He was breastfeeding and on a restricted diet due to presumed multiple food allergies. Read More

Int J Cardiol 2021 May 30;331:221-229. Epub 2021 Jan 30.

Clinical Department of Medical, Surgical and Health Science, University of Trieste, Piazzale Europa, 1, 34127 Trieste, TS, Italy.

Background: Hughes-Stovin syndrome (HSS) is a systemic disease characterized by widespread vascular thrombosis and pulmonary vasculitis with serious morbidity and mortality. The HSS International Study Group is a multidisciplinary taskforce aiming to study HSS, in order to generate consensus recommendations regarding diagnosis and treatment.

Methods: We included 57 published cases of HSS (43 males) and collected data regarding: clinical presentation, associated complications, hemoptysis severity, laboratory and computed tomography pulmonary angiography (CTPA) findings, treatment modalities and cause of death. Read More

BMJ Case Rep 2021 Feb 1;14(2). Epub 2021 Feb 1.

Cardiology, West Hertfordshire Hospitals NHS Trust, Watford, UK.

A 49-year-old female patient presented with acute-on-chronic chest pain. She was diagnosed with multiple systemic thromboemboli, including myocardial infarctions, bilateral chronic pulmonary emboli, ischaemic stroke, deep venous thrombosis and superficial thrombophlebitis. She had a background of sickle cell trait. Read More

Eur J Case Rep Intern Med 2020 23;7(12):001984. Epub 2020 Nov 23.

Centro Hospitalar e Universitário de Coimbra, Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal.

Introduction: Chest pain is a very frequent reason for seeking medical care. When there is no obvious cause, patients are sometimes subjected to tests and treatments that may be unnecessary and potentially harmful. Mondor's disease is a rare but usually benign and self-limited entity characterized by thrombophlebitis in a specific region. Read More

Mayo Clin Proc 2021 01;96(1):257-258

Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston.

Clin Med Insights Case Rep 2020 11;13:1179547620972414. Epub 2020 Nov 11.

Clinic for Radiation Oncology and Radiology, Institute of Oncology and Radiology of Serbia, Belgrade, Serbia.

Mondor's disease (MD), or superficial thrombophlebitis of the anterolateral thoracoabdominal wall, is a rare disease that presents with a palpable cord-like induration beneath the skin. It is a benign, self-limiting condition with probably underestimated significance due to the fact it may be a rare manifestation of an underlying breast carcinoma. It can also resemble breast malignancy and, if physician is not familiar with clinical features of MD, it may lead to unnecessary biopsy. Read More

Cureus 2020 Oct 20;12(10):e11061. Epub 2020 Oct 20.

Infectious Disease, University of Kansas School of Medicine, Wichita, USA.

Lemierre's syndrome is a rare but potentially fatal disease caused by oropharyngeal infections. It is characterized by thrombosis of the internal jugular vein leading to the systemic circulation of septic emboli. The common pathogen identified is Fusobacterium necrophorum. Read More

J Coll Physicians Surg Pak 2020 Nov;30(11):1217-1219

Department of Microbiology, Combined Military Hospital, Lahore, Pakistan.

Salmonella enterica serovar typhi causes one of the most common blood stream infections, the typhoid fever. However, it can cause pyogenic infections involving different sites as well. Extensively drug resistant (XDR) strains of Salmonella typhi are resistant to all first line anti-typhoidal drugs (chloramphenicol, ampicillin and trimethoprim-sulfamethoxazole) as well as ciprofloxacin and ceftriaxone. Read More

Khirurgiia (Mosk) 2020 (11):115-126

Altai State Medical University, Barnaul, Russia.

Venous thromboembolic complications (VTEC) including pulmonary embolism and acute thrombosis of deep and superficial veins of the lower extremities are often observed in postoperative period. Low-molecular-weight heparin (LMWH) is a common remedy for prevention and treatment of VTEC due to high efficiency, safety, easy use and dosage. According to the modern literature data, LMWH is characterized by different effectiveness in relation to VTEC and risk of bleeding in patients after surgical and traumatological procedures, as well as in ones with severe forms of chronic venous diseases. Read More

Br J Haematol 2020 11 10;191(3):e94-e96. Epub 2020 Sep 10.

Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Indian J Dermatol Venereol Leprol 2020 Nov-Dec;86(6):699-701

Department of Dermatology and Venerology, Akdeniz University School of Medicine, Antalya, Turkey.

Hautarzt 2020 Jul;71(Suppl 1):24-26

Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Universität München, LMU München, Frauenlobstr. 9-11, 80337, München, Deutschland.

Clin Pract Cases Emerg Med 2020 Aug;4(3):468-469

California Task Force 1 - Urban Search and Rescue, Los Angeles City Fire Department, Los Angeles, California.

Case Presentation: A 30-year-old healthy male presented with a complaint of chest pain after mild thoracic trauma sustained while rescuing stranded flood victims during Hurricane Harvey. Careful physical examination revealed a tender palpable cord along the lateral aspect of his chest consistent with a superficial thrombophlebitis.

Discussion: Mondor's disease is a superficial thrombophlebitis with myriad underlying causes that can involve the thoracic wall. Read More

Oxf Med Case Reports 2020 Aug 10;2020(8):omaa065. Epub 2020 Aug 10.

Center for Infectious Diseases, Polyclinic Department, Queen Astrid Military Hospital, Brussels, Belgium.

Chikungunya virus (CHIKV) is an arthropod-borne virus that is transmitted by mosquitoes, and its main features are high fever and (debilitating) arthritis. Infection with CHIKV, as well as other viruses, has been associated with hypercoagulable states and may be linked with the development of venous thrombosis. In fact, the development of deep venous thrombosis has been described in CHIKV infection. Read More

J Vasc Surg Venous Lymphat Disord 2021 01 10;9(1):264-274. Epub 2020 Aug 10.

Academic Section of Vascular Surgery, Division of Surgery, Department of Surgery & Cancer, Imperial College London, London, UK. Electronic address:

Background: Compression after sclerotherapy is commonly used, although the evidence base for this practice is unclear. This study aims to summarize and assess the evidence for compression therapy after sclerotherapy to inform clinical practice.

Methods: A systematic review was performed according to PRISMA guidelines via Medline and EMBASE databases (1946 to December 31, 2019) by two reviewers. Read More

Reumatol Clin 2020 Jul 17. Epub 2020 Jul 17.

Rheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address:

Introduction: Behçet's disease (BD) is a systemic inflammatory disease with various presentations. The data on the course of BD in Egyptian patients are limited.

Objectives: The objective of the study was to describe the evolution and association of the different phenotypes of BD. Read More

Pediatr Dermatol 2020 Sep 16;37(5):902-906. Epub 2020 Jul 16.

Dermatology Division, CHU Sainte-Justine, Montreal, Canada.

We report the case of a male infant born at term with kaposiform hemangioendothelioma (KHE) of the right forearm and coagulopathy. Our case was unusual as it involuted leaving subcutaneous atrophy and prominent veins, which are more commonly observed in rapidly involuting congenital hemangioma. At 3 years of age, the child developed recurrent superficial thrombophlebitis localized to the area where the KHE had regressed. Read More

Ann Vasc Surg 2020 Oct 14;68:83-87. Epub 2020 Jul 14.

Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.

Background: The liability of patients affected by novel coronavirus disease (COVID-19) to develop venous thromboembolic events is widely acknowledged. However, many particulars of the interactions between the two diseases are still unknown. This study aims to outline the main characteristics of deep venous thrombosis (DVT) and pulmonary embolism (PE) in COVID-19 patients, based on the experience of four high-volume COVID-19 hospitals in Northern Italy. Read More

Arch Ital Urol Androl 2020 Jun 23;92(2). Epub 2020 Jun 23.

Department of Surgery, Unit of Urology, ATS Sardegna - ASSL Carbonia, Ospedale Sirai, Carbonia.

Mondor's disease is a rare superficial thrombophlebitis of subcutaneous vein and usually occurs in the anterior and lateral chest. Penile Mondor's disease is a rare condition characterized by superficial thrombophlebitis of the dorsal vein of the penis. We report a rare case of atypical penile Mondor's disease involved the right posterior scrotal vein, in a patient affected by essential thrombocythemia. Read More

Cureus 2020 May 8;12(5):e8023. Epub 2020 May 8.

Internal Medicine, Dow University of Health Sciences, Karachi, PAK.

Klippel-Trenaunay Syndrome (KTS) is a rare and sporadic congenital disorder, characterized by the classical triad of port-wine stains, varicosities along with bone and soft tissue hypertrophy. Symptoms of Klippel-Trenaunay Syndrome include pain, swelling, lymphedema, bleeding, superficial thrombophlebitis, and deep vein thrombosis. The etiology remains indistinct and has been attributed to both genetic and environmental factors. Read More

Dermatol Ther 2020 Jul 3;33(4):e13768. Epub 2020 Jul 3.

Department of Dermatology, Guglielmo Marconi University, Rome, Italy.

Int J Cardiol 2020 09 20;315:92-98. Epub 2020 May 20.

Department of Cardiology, Cardiology I, University Medical Center Mainz (Johannes Gutenberg-University Mainz), Mainz, Germany.

Background: Pulmonary embolism (PE) is a frequent cause of death and morbidity. A few studies suggest that clot burden in pulmonary artery bed is related to PE patients' survival, but the impact of concomitant deep venous thrombosis and/or thrombophlebitis (DVT) on short-term survival of PE patients remains unclear. Thus, we aimed to investigate the impact of DVT on adverse outcomes in PE patients. Read More