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Clin Appl Thromb Hemost 2019 Jan-Dec;25:1076029619839150

2 Oakland University William Beaumont School of Medicine, Rochester, MI, USA.

Catheter-related (CR) thrombosis is a significant complication of midline catheters (MCs) and peripherally inserted central catheters (PICCs). Limited existing data for MCs suggest a favorable complication profile for MCs. To compare incidence of CR thrombosis between MCs and PICCs and to evaluate the impact of quantity of lumens and catheter diameter on CR thrombosis. Read More

Arch Med Sci 2019 Mar 4;15(2):393-401. Epub 2019 Mar 4.

Department of Vascular Disease, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Introduction: Little is known about pathogenetic mechanisms of superficial venous thrombosis (SVT). We aimed to investigate the systemic inflammatory response in the acute phase of SVT, the time course of inflammatory markers and involvement of inflammation in resolution of thrombus in SVT.

Material And Methods: The circulatory inflammatory parameters high-sensitivity C-reactive protein (hsCRP), tumor necrosis factor α (TNF-α), interleukins 6, 8 and 10 (IL-6, IL-8, IL-10), and markers of fibrinolytic activity tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1) and fibrinogen were determined in 68 patients with acute SVT of lower limbs, who were allocated to two groups, dalteparin 5000 IU once daily or 10 000 IU once daily. Read More

Z Rheumatol 2019 Mar 14. Epub 2019 Mar 14.

Faculty of Behavioral, Management and Social Sciences, Department Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.

Hughes-Stovin syndrome (HSS), characterized by the combination of multiple pulmonary artery aneurysms and deep vein thrombosis, is a rare and an under-recognized clinical entity with less than 40 published cases in English medical literature. Vascular venous thrombotic events, as occurring in the course of Behçet's disease (BD), are also described in HSS, e. g. Read More

PLoS One 2019 13;14(3):e0213754. Epub 2019 Mar 13.

University of Groningen, University Medical Center Groningen, Department of Critical Care, Groningen, The Netherlands.

Common methods to detect phlebitis may not be sufficient for patients in the intensive care unit (ICU). The goal of this study was to investigate the feasibility of infrared (IR) thermography to objectively detect phlebitis in adult ICU patients. We included a total of 128 adult ICU-patients in a pilot and subsequent validation study. Read More

Phlebology 2019 Mar 13:268355519835625. Epub 2019 Mar 13.

Academic Vascular Surgical Unit, Hull York Medical School, Hull, UK.

Introduction: Endovenous mechanochemical ablation (MOCA) is an increasingly popular non-thermal non-tumescent technique used to treat axial reflux in patients with superficial venous incompetence. However, the optimal management of varicose tributaries following this technique is unknown and may impact on patient outcomes. This study compares MOCA with concomitant phlebectomy (MOCAP) versus ablation with sequential phlebectomy if required (MOCAS). Read More

Aesthetic Plast Surg 2019 Feb 19. Epub 2019 Feb 19.

Adella Aesthetic, 15G, Tintyava Str., 1172, Sofia, Bulgaria.

Mondor's disease is the eponym used to describe a self-limited phlebitis or thrombophlebitis of the superficial veins localized mainly on the thoracoabdominal area of the human body. Its clinical manifestation includes painful superficial cords causing skin retraction. This medical condition could be idiopathic, iatrogenic or a manifestation of underlying pathology such as breast cancer and seems to be more common than has been previously thought. Read More

Indian J Pharmacol 2018 Nov-Dec;50(6):344-349

Department of Anaesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Objectives: Thrombosis and thrombophlebitis of the superficial venous system are common in hospitalized patients. Efficacy and safety of topical quick penetrating solution (QPS) of heparin were compared to heparin sodium topical gel for the prevention of infusion-associated phlebitis.

Materials And Methods: Patients aged 18-65 years undergoing intravenous cannulation for at least 72 h were enrolled and randomized to receive 6-8 drops of topical solution of heparin (Group sodium topical solution [QPS]) or1 g of topical gel (Group GEL) over the cannulated vein every 8 hourly for a total of 10 doses. Read More

Heart 2019 Feb 5. Epub 2019 Feb 5.

Department of Cardiology, University Hospital Southampton, Southampton, UK.

Question: Which of the following diagnoses best explains this presentation?Iatrogenic left main stem ostial stenosisSaddle pulmonary embolismMondor's syndrome (thrombophlebitis of superficial veins of chest wall)Coronary thromboembolismEpicardial fat necrosis. Read More

Blood 2019 Feb 14;133(9):906-918. Epub 2019 Jan 14.

Heart Research Institute, Newtown, NSW, Australia.

Thrombosis with associated inflammation (thromboinflammation) occurs commonly in a broad range of human disorders. It is well recognized clinically in the context of superficial thrombophlebitis (thrombosis and inflammation of superficial veins); however, it is more dangerous when it develops in the microvasculature of injured tissues and organs. Microvascular thrombosis with associated inflammation is well recognized in the context of sepsis and ischemia-reperfusion injury; however, it also occurs in organ transplant rejection, major trauma, severe burns, the antiphospholipid syndrome, preeclampsia, sickle cell disease, and biomaterial-induced thromboinflammation. Read More

Blood Coagul Fibrinolysis 2019 Mar;30(2):80-84

Laboratorio de Hematología, Sanatorio Allende.

: Hypodysfibrinogenemia and protein C deficiency are coagulopathies and in this report, we describe a young patient with both defects confirmed by molecular genetic tests. The patient was a 24-year-old woman referred for recurrent thrombophlebitis and finally deep venous thrombosis. Routine coagulation studies revealed mild decrease of protein C (0. Read More

Cochrane Database Syst Rev 2018 Dec 31;12:CD004328. Epub 2018 Dec 31.

Royal National Throat, Nose and Ear Hospital, 330 Gray's Inn Road, London, UK, WC1X 8DA.

Background: Epistaxis (nosebleed) most commonly affects children and the elderly. The majority of episodes are managed at home with simple measures. In more severe cases medical intervention is required to either cauterise the bleeding vessel, or to pack the nose with various materials. Read More

J Cutan Aesthet Surg 2018 Jul-Sep;11(3):132-135

Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany.

Background: Mondor's disease of the subcutaneous veins of the breast is an uncommon disorder. The etiology of Mondor's disease remains unclear. Usually, it is a self-limited disease. Read More

Acta Chir Belg 2019 Apr 2;119(2):137-138. Epub 2018 Nov 2.

a Department of Vascular Surgery , KAT General Hospital , Athens , Greece.

This is a rare case of a young patient with Klippel-Trenaunay syndrome that presented with extensive septic superficial thrombophlebitis of the lower extremity. Treatment included intravenous antibiotics based on cultures, anticoagulant therapy as well as surgical removal of thrombi. Read More

JAMA 2018 12;320(22):2367-2368

Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, the Netherlands.

Clinical Question: Which treatments for lower extremity superficial thrombophlebitis (ST) are associated with lower rates of venous thromboembolic events (VTEs) vs placebo?

Bottom Line: A dose of 2.5 mg of fondaparinux administered subcutaneously once daily for 45 days is associated with fewer cases of symptomatic VTE without an increase in major bleeding vs placebo. Low-molecular-weight heparin (LMWH) and nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with lower rates of ST extension or recurrence vs placebo, but data regarding symptomatic VTE remain inconclusive. Read More

Open Forum Infect Dis 2018 Oct 1;5(10):ofy249. Epub 2018 Oct 1.

Department of Infectious Diseases, Infection Control & Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Catheter-related septic thrombosis is suspected in patients with persistent central line-associated bloodstream infection (CLABSI) after 72 hours of appropriate antimicrobial therapy. The clinical diagnosis and management of this entity can be challenging as limited data are available. We retrospectively studied the clinical characteristics of patients with catheter-related septic thrombosis and the outcomes related to different management strategies. Read More

J Pharm Sci 2018 11 25;107(11):2883-2890. Epub 2018 Jul 25.

Center for Drug Delivery Research, Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, Georgia, 30341. Electronic address:

Heparinoid is commonly used for the treatment of superficial thrombophlebitis, a condition wherein inflammation and clotting occurs in the veins below the skin surface. However, stratum corneum is a major barrier that limits the delivery of hydrophilic heparinoid, in and across the skin. The aim of the present study was to develop a nonirritant topical formulation for heparinoid incorporating chemical penetration enhancers and investigate the delivery of heparinoid across the human epidermis using in vitro vertical Franz diffusion cells. Read More

Vasc Endovascular Surg 2018 Nov 18;52(8):633-635. Epub 2018 Jun 18.

1 Division of Vascular Surgery, Department of Surgery, Stanford Health Care, Stanford, CA, USA.

Background:: We report the case of a 90-year old woman who presented with septic pulmonary emboli due to suppurative thrombophlebitis at an old peripheral intravenous site.

Methods:: After unsuccessful treatment with antibiotics, the patient was taken to the operating room for excision and drainage of the purulent superficial vein.

Results:: We review the literature and discuss the presentation, risk factors, treatment options, and complications of this often-overlooked disease entity. Read More

Case Rep Emerg Med 2018 12;2018:4205628. Epub 2018 Apr 12.

Department of Emergency Medicine, Carl R. Darnall Army Medical Center, 36065 Santa Fe Avenue, Fort Hood, TX 76544, USA.

Dorsal Vein thrombosis, also known as Mondor's disease of the penis, is a superficial thrombophlebitis first described in the literature by Falco in 1955. Mondor's disease refers to a superficial thrombophlebitis of any locale. Diagnosis can be made clinically with palpation of a mobile, cord-like thickening on dorsum of penis without associated evidence of inflammation, infection, or dermatologic changes. Read More

Evid Based Complement Alternat Med 2018 24;2018:2983195. Epub 2018 Apr 24.

Research Unit of Biomedical Engineering in Anesthesia and Intensive Care Medicine and Research Unit for Complementary and Integrative Laser Medicine, TCM Research Center Graz, Medical University of Graz, 8036 Graz, Austria.

Acute superficial thrombophlebitis is a venous system disease. Animal models with mannitol induced phlebitis were treated with an orally administered "phlebitis ointment." 24 rabbits were randomly divided into 4 groups. Read More

Intern Med 2018 Sep 18;57(18):2607-2612. Epub 2018 May 18.

Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Japan.

Mondor's disease (MD) is a rare disease that manifests with a palpable cord-like induration on the body surface. In general, MD is a self-limited, benign thrombophlebitis that resolves in four to eight weeks without any specific treatment. Cases of MD can be roughly categorized into three different groups based on the site of the lesion as follows: original MD of the anterolateral thoracoabdominal wall, penile MD with dorsum and dorsolateral aspects of the penis, and axillary web syndrome with mid-upper arm after axillary surgery. Read More

J Pediatr 2018 09 26;200:289. Epub 2018 Apr 26.

Division of Clinical Immunology and Allergy Children's Hospital Los Angeles Department of Pediatrics Keck School of Medicine University of Southern California Los Angeles, California.

Minerva Med 2018 Aug 24;109(4):276-279. Epub 2018 Apr 24.

Gemelli Policlinic, Rome, Italy -

Background: Superficial thrombophlebitis (STP) is a relatively frequent pathology characterized by possible extension to the deep venous circulation, with notable local inflammatory reaction which is treated by subcutaneous administration of Fondaparinux. Stasis dermo-hypodermitis is characterized by cutaneous hyperpigmentation and eczema, treatment for which consists of the use of drugs targeting endothelial cells (mesoglycan, FFPM, sulodexide). In this study we evaluated the impact of local application of a mixture of semi-synthetic polysulfated galactosaminoglycans on the regression rate of STP and dermo-hypodermitis in patients treated with best medical therapy (BMT). Read More

Ann Vasc Dis 2018 Mar;11(1):52-56

Vascular Surgery, Aichi Medical University, Nagakute, Aichi, Japan.

Vascular Behçet's disease (BD) would keep risk of anastomotic pseudoaneurysm due to deterioration of the disease even after vascular surgery was successfully done. Therefore, it is one of the least-welcome diseases for vascular surgeons. There still exist several points on a concept and criteria of the vascular BD which not only general practitioners but also the vascular surgeons do not understand. Read More

Histopathology 2018 Sep 8;73(3):407-416. Epub 2018 Jun 8.

Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Aims: Interobserver reliability of histopathological features in differentiation between cutaneous polyarteritis nodosa (cPAN) and superficial thrombophlebitis (ST) by assessment of inter-rater agreement of five histological features was investigated.

Methods And Results: All sections of cPAN and ST were evaluated independently by three experienced pathologists and one resident of pathology. The histopathological features studied included elastic fibre distribution in the vascular wall, a smooth muscle arrangement pattern, an internal elastic lamina pattern, fibrinoid necrosis and luminal thrombosis. Read More

Hautarzt 2018 May;69(5):384-391

Universitäts-Hautklinik Tübingen, Liebermeisterstr. 25, 72076, Tübingen, Deutschland.

Background: Deep and superficial vein thromboses as well as variceal hemorrhages are emergencies. The risk of short- and long-term morbidity and mortality in vein thromboses is increased. Variceal hemorrhage harbors the risk of massive blood loss. Read More

Vasc Specialist Int 2018 Mar 31;34(1):1-9. Epub 2018 Mar 31.

Department of Vascular Surgery, University Hospital of Patras, Patras, Greece.

Purpose: To identify risk factors for recurrent thromboembolic events (RTEs) and define the optimum duration of treatment with tinzaparin in patients with superficial vein thrombosis (SVT) of the lower limbs.

Materials And Methods: A total of 147 consecutive patients with significant SVT were treated with subcutaneously administered tinzaparin. The composite primary endpoint of the study was RTE, deep-vein thrombosis (DVT) and/or pulmonary embolism (PE) at 120 days. Read More

Fertil Steril 2018 04 28;109(4):708-719.e8. Epub 2018 Mar 28.

Department of Reproductive Endocrinology, Alexandra Hospital, University of Athens, Athens, Greece.

Objective: To systematically review and appraise the existing evidence in relation to the efficacy and safety of pulsatile gonadotropin-releasing hormone (pGnRH) for the treatment of women with hypothalamic amenorrhea (HA).

Design: Systematic review and meta-analysis.

Setting: Not applicable. Read More

Wiad Lek 2018;71(1 pt 1):93-95

Katedra i Klinika Urologii i Onkologii Urologicznej Uniwersytet Medyczny w Lublinie, Lublin, Polska.

In this article we have presented a case of 31-year-old male with thickening of the skin and tender cord of superficial veins of the penis and laboratory findings of the high titer of PM/Scl-100 antibodies in the serum. The patient was referred to the Rheumatology Department due to suspected systemic sclerosis. The HRCT scan of his lungs revealed fibrous degeneration and ground-glass opacity in the lower lobes. Read More

BMJ Case Rep 2018 Mar 15;2018. Epub 2018 Mar 15.

Division of Rheumatology, Department of Medicine, NYU School of Medicine, New York, USA.

A 46-year-old Hispanic man presented with fever, genital ulcers, left eye redness and chest pain. Physical examination was notable for a healed oral ulcer and scrotal ulcers, and bilateral superficial thrombophlebitis. He was found to have new-onset pancytopenia. Read More

Cochrane Database Syst Rev 2018 02 25;2:CD004982. Epub 2018 Feb 25.

Department of Medicine and Ageing Sciences, University "G. D'Annunzio" of Chieti-Pescara, Via dei Vestini 31, Chieti Scalo, Italy, 66013.

Background: The optimal treatment of superficial thrombophlebitis (ST) of the legs remains poorly defined. While improving or relieving the local painful symptoms, treatment should aim at preventing venous thromboembolism (VTE), which might complicate the natural history of ST. This is the third update of a review first published in 2007. Read More

Vasc Med 2018 04 11;23(2):187-189. Epub 2018 Feb 11.

2 Johns Hopkins Center for Vascular Medicine, Baltimore, MD, USA.

J Clin Aesthet Dermatol 2017 Dec 1;10(12):49-51. Epub 2017 Dec 1.

Dr. Tian is with Ohio State University College of Medicine in Columbus, Ohio.

Trousseau syndrome is a rare phenomenon in cancer patients characterized by superficial migratory thrombophlebitis. In this brief report, the authors describe three recent case presentations of patients without a prior history of cancer who were treated for cellulitis prior to be admitted to the hospital. All three patients were found to have "negative" testing on venous duplex scanning. Read More

Oxf Med Case Reports 2017 Aug 2;2017(8):omx036. Epub 2017 Aug 2.

Department of Radiation Oncology, Bank of Cyprus Oncology Center 2006, Strovolos 2012, Nicosia, Cyprus.

Penile Mondor's disease is a rare condition characterized by sclerosing thrombophlebitis of the superficial dorsal penile vein. Usually its causes are benign, but it is also evident in cancer patients. We report the case of a 62-year-old man with a cT4 anal cancer (infiltration of corpora spongiosa and penile bulb), associated with extensive loco-regional lymphadenopathy, who developed painful lumps in the midline of the anterior penile surface while receiving radical chemoradiotherapy. Read More

Vasc Med 2018 06 15;23(3):289-290. Epub 2018 Jan 15.

3 OhioHealth / Riverside Methodist Hospital, Dublin, OH, USA.

J Med Case Rep 2018 Jan 9;12(1). Epub 2018 Jan 9.

Professorial Medical Unit, Teaching Hospital, Jaffna, Sri Lanka.

Background: Chest pain is one of the common presenting symptoms encountered in an emergency department. Prompt history taking and careful clinical examination do help to differentiate cardiac chest pain from other causes. Mondor's disease is a rare cause of chest pain which is often underdiagnosed due to lack of awareness. Read More

Eur J Rheumatol 2017 Dec 3;4(4):239-244. Epub 2017 Nov 3.

Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Objective: Behçet's disease is heterogeneous with clinical variability across ethnicities and geographic locations. The goal of this study was to analyze the clinical characteristics of our multi-ethnic Behçet's disease cohort at the University of Michigan.

Material And Methods: A detailed patient characterization was performed. Read More

Hematology 2018 Jul 21;23(6):351-356. Epub 2017 Dec 21.

h Departments of Medicine and Laboratory Medicine and Pathobiology , University of Toronto, Division of Hematology, Special Pregnancy Program, Mount Sinai Hospital , Toronto , Canada.

Objectives: As thromboembolism (TE) continues to be one of the principal causes of death in obstetrical patients and as the postpartum period is associated with the highest risk for TE, we sought to determine the risk factors associated with TE following cesarean section (CS).

Methods: A retrospective analysis of patients who had CS at a large tertiary referral center was conducted. Patients were identified through hospital medical records and were contacted approximately 1 year following their CS. Read More

Angiol Sosud Khir 2017;23(4):141-146

Vascular Surgery Department, St. Petersburg Scientific Research Institute of Emergency Medicine named after I.I. Dzhanelidze, Saint Petersburg, Russia.

Acute thrombosis of the lower limb deep veins remains one of the most common vascular diseases. It is characterised by formation of thrombotic masses in the system of the deep veins of the lower extremities. A serious complication associated with deep vein thrombosis is pulmonary embolism. Read More

Mil Med 2017 05;182(5):e1823-e1825

Department of Emergency Medicine, Robert Wood Johnson Medical School, 1 Robert Wood Johnson Place, New Brunswick, NJ 08901.

Phlegmasia cerulea dolens (PCD) is a rare entity that refers to a painful, edematous, and cyanotic limb due to a massive deep vein thrombosis (DVT). Due to its rarity, the exact incidence is unknown; however, it is vital that the military health care provider recognize it as the condition can be limb and life threatening. Due to the recent increase in combat-related operations, DVT has had a steady increase in the past 10 years in the military population, and as such has become a condition of special interest and surveillance in the armed forces. Read More

Prep Biochem Biotechnol 2017 Nov 20;47(10):1032-1036. Epub 2017 Nov 20.

a Department of Biotechnology, School of Biosciences and Technology , VIT University , Vellore , Tamil Nadu , India.

Streptokinase purified from Streptococcus equinus VIT_VB2 isolated from bovine milk sample was immobilized in various solid supports namely entrapment in agarose gel, calcium alginate beads and gelatin gel by cross-linking with formaldehyde. Immobilization of streptokinase in calcium alginate beads showed maximum efficiency (81.8 ± 1. Read More

Am J Med 2018 Mar 4;131(3):307-316.e2. Epub 2017 Oct 4.

Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minn; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minn; Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minn.

Background: The independent association of recent infection with venous thromboembolism is uncertain. The study aims were to test both overall infection (site unspecified) and specific infection sites as potential risk factors for deep vein thrombosis and pulmonary embolism adjusting for other known venous thromboembolism factors.

Methods: By using Rochester Epidemiology Project resources, we identified all Olmsted County, Minnesota, residents with objectively diagnosed incident deep vein thrombosis or pulmonary embolism over the 13-year period 1988 to 2000 (cases; n = 1303) and 1 to 2 residents without venous thromboembolism matched to each case on age, sex, and incident venous thromboembolism date (controls; n = 1494). Read More

Ann Surg Treat Res 2017 Aug 28;93(2):98-102. Epub 2017 Jul 28.

Department of Surgery, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

Purpose: Varicose veins with great saphenous vein (GSV) insufficiency is prevalent. Among various surgical treatments for varicose veins, cryosurgery of GSV is an alternative minimally invasive technique that could leave fewer scars and replace conventional stripping with ambulatory phlebectomy. This study sought to assess outcomes including efficacy and safety of cryosurgery for varicose veins. Read More

BMJ Case Rep 2017 Jul 14;2017. Epub 2017 Jul 14.

Department of Internal Medicine, Hospital Garcia de Orta, Almada, Portugal.

Cancer is frequently associated with a hypercoagulable state. Almost 15% of patients with cancer will suffer a thromboembolic event during their clinical course. The aetiology of this hypercoagulable state is multifactorial and includes procoagulant factors associated with malignancy as well as the host's inflammatory response. Read More

Kyobu Geka 2017 Jul;70(7):504-506

Department of Cardiovascular Surgery, Totsuka Kyoritsu Daini Hospital, Yokohama, Japan.

Klippel-Trenaunay syndrome( KTS) is a complex congenital anomaly characterized by lower extremity varix and venous malformations, port-wine stains, and soft tissue and bone hypertrophy. We present a case of a 35-year-old man of KTS with pulmonary embolism (PE). The patient was referred to our hospital complaining of the leg pain and sudden onset of dyspnea. Read More

Crit Care Nurs Q 2017 Jul/Sep;40(3):201-209

Division of Pulmonary and Critical Care Medicine (Drs Alhassan, Gandhi, Naddour, Singh, and Bihler) and Department of Medicine (Dr Pelinescu), Allegheny General Hospital, Pittsburgh, Pennsylvania.

Venous thromboembolism (VTE) has a wide range of clinical presentations. Deep venous thrombosis may occur in upper or lower extremities or in visceral veins. Extremity deep venous thrombosis usually manifests with unilateral painful swelling in the limb, while visceral deep venous thrombosis manifestations vary on the basis of the involved organ. Read More

Br J Haematol 2018 06 17;181(5):682-684. Epub 2017 Apr 17.

King's College Hospital NHS Foundation Trust, London, UK.