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    Safety of parenteral nutrition in newborns: Results from a nationwide prospective cohort study.
    Clin Nutr 2017 Feb 8. Epub 2017 Feb 8.
    AGEPS, Pharmaceutical Establishment of Paris Hospitals, APHP, Paris, France.
    Background & Aims: Limited or delayed availability of parenteral nutrition (PN) solutions, as well as difficulties in ordering are often identified as reasons for non-compliance with international guidelines in newborns. This study aims at assessing the modality of use and safety of premixed standardized PN solutions in a nationwide prospective cohort of newborns treated in clinical practice.

    Methods: Two premixed fixed formulations with respective osmolarity of 715 and 790 mOsm/L specifically designed for neonates were made available throughout the country for clinical use from birth onwards. Read More

    Risk Factors in Children Older than 5 Years with Pneumococcal Meningitis: Data from a National Network.
    Pediatr Infect Dis J 2016 Dec 13. Epub 2016 Dec 13.
    1 Urgences pédiatriques, CHU Nantes, Hôpital Mère-Enfant, 44093 Nantes 2 ACTIV, Association Clinique et Thérapeutique Infantile du Val de Marne, 94100 Saint-Maur des Fossés, France 3 Université Paris Est, IMRB-GRC GEMINI, 94000 Créteil, France 4 Unité Court Séjour, Petits Nourrissons, Service de Néonatologie, Centre Hospitalier Intercommunal de Créteil, 94000 Créteil, France 5 Laboratoire de génétique humaine des maladies infectieuses, institut national de la santé et de la recherche médicale, UMR1163, Institut IMAGINE, 75015 Paris, France; Faculté de médecine de Necker, Université Paris V René-Descartes, 75015 Paris, France; Centre d'études des déficits immunitaires (CEDI), AP-HP, hôpital Necker-Enfants-Malades, 75015 Paris, France 6 Centre National de Référence des Pneumocoques, AP-HP, HEGP (Hôpital Européen Georges Pompidou), Université Paris V, France 7 Pédiatrie générale, CHU Nantes, Hôpital Mère-Enfant, 44093 Nantes.
    Introduction: The occurrence of meningitis in children > 5 years old may be associated with specific predisposing factors that can be anatomic, such as cerebrospinal fluid (CSF) fistula or breach, or related to genetic susceptibility or N inborn or acquired immunologic defect. This study aimed to assess the anatomical and immunologic risk factors in children > 5 years old with pneumococcal meningitis and prospectively enrolled in the French national meningitis network.

    Methods: We analyzed all data for children 5 to 15 years old with a diagnosis of pneumococcal meningitis between 2001 and 2013. Read More

    Hepatic Vena Cava Syndrome : New Concept of Pathogenesis.
    Hepatol Res 2017 Feb 7. Epub 2017 Feb 7.
    Center for Vein, Lymphatic & Vascular Malformation, George Washington University, Washington, USA.
    Hepatic vena cava syndrome (HVCS) also known as membranous obstruction of inferior vena cava was considered a rare congenital disease and included under Budd Chiari syndrome. It is now recognized as a bacterial infection induced disease related to poor hygienic living condition. Localized thrombophlebitis of IVC at the site close to hepatic veins (HV) outlets is the initial lesion which converts on resolution into stenosis or complete obstruction, the circulatory equilibrium being maintained by development of cavo-caval collateral anastomosis. Read More

    Descending necrotizing mediastinitis with Lemierre's syndrome.
    Gen Thorac Cardiovasc Surg 2017 Feb 1. Epub 2017 Feb 1.
    Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
    Descending necrotizing mediastinitis is a severe infection of the mediastinum. Lemierre's syndrome manifests as thrombophlebitis in the cervical veins, which is caused by a neck infection. A 50-year-old woman had a fever with a 13-day history of neck pain. Read More

    [Evaluation of clinical evidence for dalbavancin].
    Enferm Infecc Microbiol Clin 2017 Jan;35 Suppl 1:33-37
    Servicio de Enfermedades Infecciosas, Hospital Universitari Vall d'Hebron, Barcelona, España. Electronic address:
    Gram-positive infections are currently a therapeutic challenge because of the emergence of strains resistant to first-line antibiotics. Consequently, in the last few years, new antibiotics have been developed with activity against multiresistant Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and strains with intermediate sensitivity to vancomycin. Among the new antibiotics approved for the treatment of these microorganisms, dalbavancin is a semisynthetic lipoglycopeptide derived from teicoplanin, but has a superior efficacy profile to the latter. Read More

    Comparison of ultrasound-guided endovenous laser ablation and radiofrequency for the varicose veins treatment: An updated meta-analysis.
    Int J Surg 2017 Jan 21;39:267-275. Epub 2017 Jan 21.
    Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing 100853, China.
    Purpose: To investigate and compare the relative efficacy, recurrence and complications of endovenous laser ablation (EVLA) and radiofrequency ablation (RFA) for the treatment of varicose veins patients.

    Methods: Searches were applied to the Cochrane Library as well as MEDLINE, EMBASE, BIOSIS databases. 12 articles published in English (10 randomized controlled trials and 2 cohort study) were identified from specialized trails. Read More

    [Superficial venous thrombosis. A state of art].
    Orv Hetil 2017 Jan;158(4):129-138
    II. Sebészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Kútvölgyi út 4., 1125.
    For a long time superficial thrombophlebitis has been thought to be a rather benign condition. Recently, when duplex ultrasound technique is used for the diagnosis more and more often, the disease is proved to be more dangerous than anticipated. Thrombosis propagates to the deep veins in 6-44% and pulmonary embolism was observed on the patients in 1,5-33%. Read More

    Mechanical Compression Effects on the Secretion of vWF and IL-8 by Cultured Human Vein Endothelium.
    PLoS One 2017 12;12(1):e0169752. Epub 2017 Jan 12.
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel.
    Short peripheral catheters are ubiquitous in today's healthcare environment enabling effective delivery of fluids and medications directly into a patient's vasculature. However, complications related to their use, such as short peripheral catheter thrombophlebitis (SPCT), affect up to 80% of hospitalized patients. While indwelling within the vein, the catheters exert prolonged constant pressure upon the endothelium which can trigger inflammation processes. Read More

    The Effectiveness of Diclofenac Sodium in the Treatment of Mondor's Disease of the Breast: The Topical Patch Compared to the Oral Capsules.
    Breast J 2017 Jan 12. Epub 2017 Jan 12.
    Department of Pharmacy, Al Ansar General Hospital, Medina, Saudi Arabia.
    Mondor's disease of the breast is a rare, benign sclerosing superficial thrombophlebitis of the subcutaneous veins of the anterior or lateral chest wall, which is treated conservatively. We aim in this study to evaluate the outcome and effectiveness of our treatment protocol using oral diclofenac sodium and topical diclofenac sodium patch in 172 patients. A retrospective database analysis of 172 female patients between January 2001 and December 2010 was done. Read More

    Brachial insertion of fully implantable venous catheters for chemotherapy: complications and quality of life assessment in 35 patients.
    Einstein (Sao Paulo) 2016 Oct-Dec;14(4):473-479
    Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
    Objective: To prospectively evaluate the perioperative safety, early complications and satisfaction of patients who underwent the implantation of central catheters peripherally inserted via basilic vein.

    Methods: Thirty-five consecutive patients with active oncologic disease requiring chemotherapy were prospectively followed up after undergoing peripheral implantation of indwelling venous catheters, between November 2013 and June 2014. The procedures were performed in the operating room by the same team of three vascular surgeons. Read More

    Randomized trial of radiofrequency ablation versus conventional surgery for superficial venous insufficiency: if you don't tell, they won't know.
    Clinics (Sao Paulo) 2016 Nov 1;71(11):650-656. Epub 2016 Nov 1.
    Hospital Israelita Albert Einstein, Division of Vascular and Endovascular Surgery, São Paulo/SP, Brazil.
    Objectives:: This study compared radiofrequency ablation versus conventional surgery in patients who had not undergone previous treatment for bilateral great saphenous vein insufficiency, with each patient serving as his own control.

    Method:: This was a randomized controlled trial that included 18 patients and was carried out between November 2013 and May 2015. Each of the lower limbs of each patient was randomly assigned to undergo either radiofrequency ablation or conventional surgery. Read More

    Methicillin-Resistant Staphylococcus aureus as a Cause of Lemierre's Syndrome.
    Pediatr Infect Dis J 2016 Dec 12. Epub 2016 Dec 12.
    Departments of 1Pediatrics and 2Microbiology, University of Alabama at Birmingham, AL; 3Department of Pediatrics, University of California, San Diego.
    Lemierre's syndrome (LS) or jugular vein suppurative thrombophlebitis is well described in literature. The organisms most often responsible are Fusobacterium necrophorum or anaerobic flora. We present a case of LS with an atypical microbiologic cause, methicillin-resistant Staphylococcus aureus (MRSA). Read More

    Reasons for the persistent incidence of venous thromboembolism.
    Thromb Haemost 2017 Jan 15;117(2):390-400. Epub 2016 Dec 15.
    John A. Heit, MD, Stabile 6-Hematology Research, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA, Tel.: +1 507 284 4634, Fax: +1 507 266 9302, E-mail:
    Reasons for trends in venous thromboembolism (VTE) incidence are uncertain. It was our objective to determine VTE incidence trends and risk factor prevalence, and estimate population-attributable risk (PAR) trends for each risk factor. In a population-based cohort study of all residents of Olmsted County, Minnesota from 1981-2010, annual incidence rates were calculated using incident VTE cases as the numerator and age- and sex-specific Olmsted County population estimates as the denominator. Read More

    [Thromboangiitis obliterans (Buerger's disease): state of the art].
    Angiol Sosud Khir 2016;22(4):185-192
    Ivano-Frankovsk National Medical University, Ivano-Frankovsk, Ukraine.
    Thromboangiitis obliterans (Buerger's disease) is systemic vasculitis with predominant development of thrombotic occlusions of small-to-medium diameter arteries of distal portions of both upper and lower limbs. A distinctive feature of Buerger's disease from other vasculitides is the involvement of the venous bed into the pathological process in the form of migrating thrombophlebitis. The disease is encountered more often in young adult males, predominantly tobacco smokers. Read More

    Clinical case report: discitis osteomyelitis complicated by inferior vena cava venous thrombosis and septic pulmonary emboli.
    Radiol Case Rep 2016 Dec 17;11(4):370-374. Epub 2016 Sep 17.
    Department of Radiology, Einstein Medical Center, 5501 Old York Road, Philadelphia, PA 19141, USA.
    Viridans group streptococcus is an infrequent cause of osteomyelitis that is found in association with infective endocarditis. Only a few studies report viridans osteomyelitis in the absence of endocarditis. Vertebral pyogenic osteomyelitis can sometimes be complicated by psoas or paraspinal abscesses. Read More

    Diverticulitis: a comprehensive review with usual and unusual complications.
    Insights Imaging 2017 Feb 22;8(1):19-27. Epub 2016 Nov 22.
    Department of Radiology, Hacettepe University, School of Medicine, Ankara, Turkey.
    Diverticulitis is characterized by inflammation of the outpouchings of the bowel wall. Imaging findings of diverticulitis include edematous thickening of the bowel wall with inflammatory changes within the adjacent mesenteric fat. Uncomplicated diverticulitis can be treated conservatively; however, complicated diverticulitis may not be responsive to medical treatment and life-threatening conditions may occur. Read More

    Quantitative T2 mapping for detection and quantification of thrombophlebitis in a rabbit model.
    J Biomech 2017 Jan 15;50:151-157. Epub 2016 Nov 15.
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel; Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA.
    Short peripheral catheter thrombophlebitis (SPCT), a sterile inflammation of the vein wall, is the most common complication associated with short peripheral catheters (SPCs) and affects up to 80% of hospitalized patients receiving IV therapy. Extensive research efforts have been devoted for improvement and optimization of the catheter material, but means for examination of any novel design are limited, inaccurate and require costly comprehensive pre-clinical and clinical trials. Therefore, there is a conclusive need for a reliable quantitative method for evaluation of SPCT, in particular for research purposes examining the thrombophlebitis-related symptoms of any novel catheter design. Read More

    Pylephlebitis with Liver Abscess Secondary to Chronic Appendicitis: A Radiological Conundrum.
    J Clin Imaging Sci 2016 20;6:37. Epub 2016 Sep 20.
    Department of Radiology and Diagnostic Imaging, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
    Septic thrombophlebitis of the portal vein and/or its intra-hepatic branches (pylephlebitis) with associated liver abscess formation is a rare and potentially fatal complication of intra-abdominal infection. We present such a case that was caused by missed chronic appendicitis. Imaging findings can be complex and mimic other diseases leading to a diagnostic conundrum. Read More

    Predicting and preventing thromboembolic events in patients receiving cisplatin-based chemotherapy for germ cell tumours.
    Eur J Cancer 2016 Dec 4;69:151-157. Epub 2016 Nov 4.
    Department of Cancer Medicine, Institut Gustave Roussy, Université Paris-Sud, 94800 Villejuif, France. Electronic address:
    Background: Patients with germ cell tumours (GCT) receiving cisplatin-based chemotherapy are at high risk of thromboembolic events (TEE). Previously, we identified serum lactate dehydrogenase (LDH) and body surface area (BSA) as independent predictive factors for TEE. The aim of this study was to validate these predictive factors and to assess the impact of thromboembolism prophylaxis in patients at risk of deep venous thrombosis (DVT). Read More

    The role of Fusobacterium necrophorum in pharyngotonsillitis - A review.
    Anaerobe 2016 Dec 28;42:89-97. Epub 2016 Sep 28.
    Department of Biomedicine, Aarhus University, Denmark. Electronic address:
    Fusobacterium necrophorum is a gram-negative anaerobic bacterium that is the causative agent of the invasive disease Lemierre's syndrome. In addition, it is also associated with peritonsillar abscess formation and otitis media in small children. Recent research has shown that F. Read More

    Safety, efficacy, and patient-perceived satisfaction of peripherally inserted central catheters in terminally ill cancer patients: a prospective multicenter observational study.
    Support Care Cancer 2016 Dec 26;24(12):4987-4992. Epub 2016 Jul 26.
    Medical Oncology and Hematology, Department of Internal Medicine, Pusan National University Yangsan Hospital, 20, Geumo-ro, Mulgeum-eup, Yangsan-si, Gyeongsangnam-do, South Korea.
    Purpose: The purpose of this study was to investigate the safety, efficacy, and subjective satisfaction of peripherally inserted central catheters (PICCs) in terminally ill cancer patients.

    Methods: All PICCs were inserted by an interventional radiologist with radiological guidance. We monitored the occurrence of PICC-related complication and evaluated the patient-perceived satisfaction for PICC using semi-structured questionnaire. Read More

    Ultrasound-guided deep-arm veins insertion of long peripheral catheters in patients with difficult venous access after cardiac surgery.
    Heart Lung 2017 Jan - Feb;46(1):46-53. Epub 2016 Oct 22.
    School of Nursing, University of Trieste, Piazzale Valmaura 9, 34147, Trieste, Italy; Azienda Sanitaria Universitaria Integrata, Strada di Fiume 447, 34148, Trieste, Italy. Electronic address:
    Objectives: To analyze success rate, dwell-time, and complications of long peripheral venous catheters (L-PVCs) inserted under ultrasound guidance.

    Background: In difficult venous access (DVA) patients, L-PVC can represent an alternative to central or midline catheters.

    Methods: Prospective observational study. Read More

    Bodybuilding-induced Mondor's disease of the chest wall.
    Phys Ther Sport 2017 Jan 4;23:133-135. Epub 2016 Sep 4.
    Department of Internal Medicine, Central Hospital of Bolzano|Bozen, Lorenz-Böhler-Street 5, 39100, Bolzano|Bozen (BZ), Italy. Electronic address:
    Objective: To describe the association of bodybuilding abdominal exercise with the development of superficial sclerosing thrombophlebitis of the anterolateral thoracoabdominal wall.

    Design: A single case study.

    Setting: University-affiliated regional community hospital. Read More

    [Thrombotic skin gangrene: A rare extra-intestinal manifestation of ulcerative colitis].
    Ann Dermatol Venereol 2017 Feb 18;144(2):109-112. Epub 2016 Oct 18.
    Service de dermatologie, CHU Farhat Hached, avenue Ibn El Jazzar, 4000 Sousse, Tunisie.
    Background: Thrombotic cutaneous gangrene is a rare extra-intestinal manifestation of ulcerative colitis with a severe prognosis.

    Case Report: A 35-year-old woman with a 7-year history of ulcerative colitis presented with extensive ecchymotic lesions that began a few hours earlier. On examination, she was febrile with multiple necrotic lesions. Read More

    Evaluating the Potential of Routine Blood Tests to Identify the Risk of Deep Vein Thrombosis: A 1-Year Monocenter Cohort Study.
    Angiology 2016 Oct 20. Epub 2016 Oct 20.
    Department of Medical, Surgical Sciences and Advanced Technologies, G.F. Ingrassia, University of Catania, Catania, Italy.
    Study on 295 consecutive medical patients to evaluate the potential of routine blood tests to identify the risk of deep vein thrombosis (DVT). The tests included in a DVT risk stratification model system were erythrocyte sedimentation rate, antithrombin III, C-reactive protein, D-dimer, and N-terminal pro-brain natriuretic peptide. The DVT risk stratification system was moderately prognostic (area under the curve: 0. Read More

    Black veins: a case of minocycline-induced pigmentation post-sclerotherapy and a review of literature.
    J Cutan Pathol 2017 Jan 20;44(1):83-92. Epub 2016 Oct 20.
    Dermatology, Phlebology and Fluid Mechanics Research Laboratory, St Vincent's Centre for Applied Medical Research, Sydney, Australia.
    Minocycline-induced pigmentation (MIP) is an uncommon but well-described adverse effect of oral minocycline treatment. MIP is clinically and histopathologically distinct from post-sclerotherapy pigmentation. We report a case of a patient presenting with blackened skin overlying veins recently treated with endovenous laser and foam sclerotherapy. Read More

    Coagulation Profile as a Risk Factor for 30- Day Morbidity and Mortality Following Posterior Lumbar Fusion.
    Spine (Phila Pa 1976) 2016 Oct 17. Epub 2016 Oct 17.
    *Department of Medical Education, Icahn School of Medicine at Mount Sinai, New York, NY, USA †Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA ‡Department of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY.
    Study Design: Retrospective cohort study.

    Objective: To identify associations between abnormal coagulation profile and postoperative morbidity and mortality in patients undergoing posterior lumbar fusion (PLF).

    Summary Of Background Data: The literature suggests that abnormal coagulation profile is associated with postoperative complications, notably the need for blood transfusion. Read More

    [Let us not forget the Lemierre's Syndrome.]
    Recenti Prog Med 2016 Sep;107(9):487-491
    Clinica di Malattie Infettive, AO "Santa Maria" , Terni.
    Lemierre's syndrome is a dangerous potential sequela of pharyngitis that results in septic thrombophlebitis of the internal jugular vein. A high index of suspicion is needed to consider this diagnosis in the workup of pharyngitis and should be aggressively treated once. Gram-negative anaerobic bacteria, mainly Fusobacterium necrophorum are implicated. Read More

    Postoperative seizure following transforaminal percutaneous endoscopic lumbar discectomy.
    Asian J Neurosurg 2016 Oct-Dec;11(4):450
    Department of Neurosurgery Clinic, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
    Endoscopic surgery for lumbar disc herniation has been available for more than 30 years. Transforaminal percutaneous endoscopic lumbar discectomy is a well-known, safe, and effective method used for the treatment of the lumbar disc herniation. The published complications of the transforaminal percutaneous endoscopic lumbar discectomy consist of infections, thrombophlebitis, dysesthesia, dural tear, vascular injury, and death. Read More

    Impact of HIGH BMI on Pregnancy: Maternal and Foetal Outcome.
    J Obstet Gynaecol India 2016 Oct 13;66(Suppl 1):192-7. Epub 2016 Jan 13.
    Department of Obstetrics and Gynaecology, Government Medical College, Aurangabad, India.
    Aim And Objectives: To review the effects of obesity (BMI > 30) on antepartum risk/intrapartum risk. To study neonatal outcome of pregnant women with raised BMI.

    Material Method: BMI of 500 pregnant women booked before 12 weeks calculated and categorised as normal, overweight, obese and morbidly obese at GMCH, Aurangabad. Read More

    Hepatic Infarction Caused by Portal Vein Thrombophlebitis Misdiagnosed as Infiltrative Hepatic Malignancy with Neoplastic Thrombus.
    Korean J Gastroenterol 2016 Sep;68(3):156-60
    Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
    Portal vein thrombosis (PVT) is a form of venous thrombosis that usually presents in chronic form without any sequalae in patients with hepatocellular carcinoma (HCC) or liver cirrhosis. Accurate differential diagnosis of bland PVT from neoplastic PVT is an important step for planning treatment options, but the acute form can be challenging. Here we present a case of acute hepatic infarction caused by acute bland PVT combined with pylephlebitis, which was misdiagnosed as infiltrative hepatic malignancy with neoplastic PVT owing to the perplexing imaging results and elevated tumor markers. Read More

    Life threatening hemoptysis from Hughes Stovin syndrome: Is it that rare?
    Respir Med Case Rep 2016 15;19:98-102. Epub 2016 Aug 15.
    Department of Cardiothoracic Surgery, Badr Hospital, Helwan University, Egypt.
    Introduction: Hughes-Stovin syndrome is a life-threatening disorder of unknown etiology. This condition is characterized by vasculitis, deep venous thrombosis and aneurysms that mainly involve the pulmonary arteries resulting in hemoptysis. It has been described in literature less than 40 times. Read More

    Pelvic Inflammatory Disease: Multimodality Imaging Approach with Clinical-Pathologic Correlation.
    Radiographics 2016 Sep-Oct;36(5):1579-96
    From the Department of Diagnostic Radiology (M.V.R., M.M., H.B.D., M.S.) and Department of Obstetrics and Gynecology and Reproductive Sciences (M.L.M.), Yale University School of Medicine, 333 Cedar St, PO Box 208042, Room TE-2, New Haven, CT 06520.
    Pelvic inflammatory disease (PID) is a common medical problem, with almost 1 million cases diagnosed annually. Historically, PID has been a clinical diagnosis supplemented with the findings from ultrasonography (US) or magnetic resonance (MR) imaging. However, the diagnosis of PID can be challenging because the clinical manifestations may mimic those of other pelvic and abdominal processes. Read More

    Treatment of Orbital Complications Following Acute Rhinosinusitis in Children.
    Balkan Med J 2016 Jul 1;33(4):401-6. Epub 2016 Jul 1.
    Department of Otorhinolaryngology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China; Institute of Eye and ENT, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
    Background: The orbital complications account for about 80% of all complications secondary to acute rhinosinusitis. If the treatment is not correct and in time, orbital complications could progress rapidly, leading to optic neuritis, cavernous sinus thrombophlebitis or life-threatening intracranial complications.

    Aims: To evaluate the therapeutic efficacy of conservative therapy for the patients with orbital cellulitis and endoscopic sinus surgery (ESS) performed on patients with subperiosteal abscess (SPA) secondary to acute rhinosinusitis in children. Read More

    Umbilical Cord Care in the Newborn Infant.
    Pediatrics 2016 Sep;138(3)
    Postpartum infections remain a leading cause of neonatal morbidity and mortality worldwide. A high percentage of these infections may stem from bacterial colonization of the umbilicus, because cord care practices vary in reflection of cultural traditions within communities and disparities in health care practices globally. After birth, the devitalized umbilical cord often proves to be an ideal substrate for bacterial growth and also provides direct access to the bloodstream of the neonate. Read More

    Low dose time-resolved CT-angiography in pediatric patients with venous malformations using 3rd generation dual-source CT: Initial experience.
    Eur J Radiol Open 2016 12;3:216-22. Epub 2016 Aug 12.
    Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
    Objectives: To prospectively evaluate the diagnostic value and radiation dose of time-resolved CT-Angiography (4D-CTA) in pediatric patients with venous malformations using 3rd generation dual-source CT (DSCT) at 70 kVp tube voltage.

    Methods: Between November 2014 and August 2015, seven children (2 male, 5 female; median age, 9 years; range 3-12 years) with suspected peripheral, non-cerebral, venous malformations were included in this feasibility study and underwent US, MRI and 4D-CTA. All three imaging modalities were analyzed and compared individually by an experienced interventional radiologist and a pediatric surgeon using a 5-point Likert scale, with regard to diagnosis of the vascular anomaly, additional information like presence of thrombophlebitis and lesion extension, flow dynamics, localization, volume and significance for treatment planning. Read More

    A Compelling Case for the Use of Perioperative Zymogen Protein C for Increased Patient Safety.
    Adv Exp Med Biol 2016 ;923:15-21
    Synthesizer Inc., Ellicott City, MD, USA.
    It is imperative to maintain normal blood flow to provide adequate oxygen supply to specific organs and cells, as well as for the removal of metabolic byproducts. Therefore, any situation that results in blood clotting can injure or kill living tissues. In this paper, we describe a case where a protein C deficient subject who would, by all medical indicators, be at 100 % risk of experiencing thrombophlebitis, deep vein thrombosis, and or lung emboli, is able to escape all pathologies by using perioperative zymogen protein C (ZPC). Read More

    The Use of Cyclosporine A in Rheumatology: a 2016 Comprehensive Review.
    Clin Rev Allergy Immunol 2016 Aug 11. Epub 2016 Aug 11.
    Experimental laboratory of Immunological and Rheumatologic Researches, IRCCS Istituto Auxologico Italiano, Via Zucchi 18, 20095, Cusano Milanino, Milan, Italy.
    Cyclosporine A, an inhibitor of calcineurin, exerts an immunomodulator action interfering with T cell activation. Even though novel therapeutic tools have emerged, CyA still represents a suitable option in several clinical rheumatology settings. This is the case of refractory nephritis and cytopenias associated with systemic lupus erythematosus. Read More

    To anticoagulate? Controversy in the management of thrombotic complications of head & neck infections.
    Int J Pediatr Otorhinolaryngol 2016 Sep 6;88:129-35. Epub 2016 Jun 6.
    Division of Otolaryngology-Head and Neck Surgery McMaster University, Hamilton, Canada.
    Objective: To review the thrombotic complications of head and neck infections, including Lemierre's syndrome, and their management.

    Methods: A retrospective review of pediatric patients presenting to McMaster Children's Hospital from 2009 to 2013 was undertaken. The literature was reviewed for evidence regarding the use of anticoagulation therapy in this population. Read More

    Mortality in people with intellectual disabilities in England.
    J Intellect Disabil Res 2017 Jan 2;61(1):62-74. Epub 2016 Aug 2.
    Norah Fry Research Centre, School for Policy Studies, University of Bristol, Bristol, UK.
    Background: People with intellectual disabilities (IDs) die at younger ages than the general population, but nationally representative and internationally comparable mortality data about people with ID, quantifying the extent and pattern of the excess, have not previously been reported for England.

    Method: We used data from the Clinical Practice Research Datalink database for April 2010 to March 2014 (CPRD GOLD September 2015). This source covered several hundred participating general practices comprising roughly 5% of the population of England in the period studied. Read More

    Septic Pulmonary Embolism Caused by Infected Pacemaker Leads After Replacement of a Cardiac Resynchronization Therapy Device.
    Am J Case Rep 2016 Jul 20;17:507-11. Epub 2016 Jul 20.
    Department of Cardiology, Hospital Group Twente, Almelo-Hengelo, Netherlands.
    BACKGROUND Cardiac resynchronization therapy (CRT) has been demonstrated to reduce morbidity and mortality in patients with advanced, drug-refractory heart failure. Procedure-related mortality is less than 1% in larger studies. Approximately10% of CRT patients have to undergo surgical revision because of infections, dislocations, or unacceptable electrical behavior manifested as high threshold, unstable sensing, or unwanted phrenic nerve stimulation. Read More

    Lemierre's Syndrome Associated Mycotic Aneurysm of the External Carotid Artery with Primary Internal Carotid Artery Occlusion in a Previously Healthy 18-Year-Old Female.
    Ann Vasc Surg 2016 Oct 13;36:291.e11-291.e14. Epub 2016 Jul 13.
    Division of Vascular Surgery, Department of Surgery, UT Southwestern Medical Center, Dallas, TX. Electronic address:
    Lemierre's syndrome is a rare life-threatening condition characterized by internal jugular vein thrombosis and is typically associated with a gram-negative infection with septic metastasis secondary to a retropharyngeal abscess that involves the vasculature of the head and neck. We report a case of Lemierre's syndrome in an 18-year-old female adolescent who developed an internal carotid artery occlusion and ipsilateral external carotid artery (ECA) mycotic aneurysm complicated by fulminant pseudomonal sepsis. The patient was managed with open ligation of the ECA with essentially complete recovery. Read More

    Necrotizing Thrombophlebitis Secondary to Mycobacterium Chelonae in a Hemodialyzed Patient.
    Am J Dermatopathol 2016 Jul 12. Epub 2016 Jul 12.
    *Department of Dermatology, Hospital Universitario 12 de Octubre, Madrid, Spain †i+12 Research Institute, Universidad Complutense, Madrid, Spain Departments of ‡Nephrology, and §Pathology, Hospital Universitario 12 de Octubre, Madrid, Spain.

    Fosaprepitant dimeglumine for the management of chemotherapy-induced nausea and vomiting: patient selection and perspectives.
    Cancer Manag Res 2016 22;8:77-82. Epub 2016 Jun 22.
    Department of Medicine, Einstein Medical Center, Philadelphia, PA, USA.
    Chemotherapy-induced nausea and vomiting (CINV) is a debilitating side effect of antineoplastic agents. Several treatment regimens are used to address this problem. Fosaprepitant is a neurokinin-1 receptor blocker used in the prevention and treatment of CINV, especially for moderately and severely emetogenic chemotherapy. Read More

    Clinical Features and Developing Risks of Saphenous Vein Thrombophlebitis.
    Ann Vasc Dis 2016 4;9(2):85-90. Epub 2016 May 4.
    Department of Vascular Surgery, Tome City Hospital, Tome, Miyagi, Japan.
    We evaluated the clinical features and the risks of 14 patients with 14 limbs affected by saphenous vein thrombophlebitis from April 2007 to May 2013 and compared the results with patients undergoing operative repair of varicose veins (127 patients, 193 limbs) during the study period. The frequency of patients with a body mass index over 25 (78.6% vs. Read More

    Superior mesenteric vein thrombosis as a complication of cecal diverticulitis: A case report.
    Int J Surg Case Rep 2016 15;25:71-4. Epub 2016 Jun 15.
    Mercy Hospital and Medical Center, Department of General Surgery, United States. Electronic address:
    Pylephlebitis is an uncommon complication of uncontrolled intra-abdominal infection that is associated with high morbidity and mortality. We present our experience with a unique case of cecal diverticulitis and septic thrombophlebitis of the superior mesenteric vein that was promptly diagnosed with high-resolution imaging and blood cultures. Antibiotic and anticoagulation therapy was instituted on confirming the diagnosis with magnetic resonance imaging (MRI) to control the infection and prevent propagation of the thrombus. Read More

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