Search Our Scientific Publications & Authors

Pan Afr Med J 2018 9;31:97. Epub 2018 Oct 9.

Service de Neurochirurgie CHU Yopougon, Abidjan, Côte d'Ivoire.

This case study presents an unusual pathogenic association among several cranioencephalic lesions characterized by the association of osteitis of the cranial vault, due to Aspergillus fumigatus, with underlying thrombophlebitis complicated by intracranial hypertension resulting from hydrocephalus. The study involved a 43-year old HIV (human immunodeficiency virus) negative man with multi-recurrent infection of the frontal scalp. The patient was successfully treated with cerebrospinal fluid diversion (CFD), Ketoconazole and low molecular weight heparin. Read More

BMJ Case Rep 2019 Apr 15;12(4). Epub 2019 Apr 15.

Department of Hepatopancreaticobiliary Surgery, Cambridge University Hospital, Cambridge, Cambridgeshire, UK.

Portal pyaemia or pylephlebitis is a form of septic (often suppurative) thrombophlebitis of the portal venous system. It may develop as a complication of intra-abdominal sepsis, such as diverticulitis or appendicitis. Patients typically present with a high fever that is sometimes accompanied by jaundice. Read More

Brain Nerve 2019 Apr;71(4):329-333

Department of Dermatology, Saitama Medical University.

Behçet disease is an inflammatory disease of unknown etiology that affects various organs, such as the skin, eye, central nervous system, and blood vessels. Mucocutaneous manifestations are characterized by oral ulcers, genital ulcers, erythema nodosum, papulopustular eruptions, and thrombophlebitis. The diagnosis is based on the diagnostic criteria defined by the Japanese Ministry of Health, Labour and Welfare. Read More

ANZ J Surg 2019 Apr 11. Epub 2019 Apr 11.

Department of Otorhinolaryngology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Braz J Med Biol Res 2019 Apr 8;52(4):e8330. Epub 2019 Apr 8.

TopMed Medical Center, Tîrgu Mureş, Romania.

We sought to assess clinical characteristics and pattern of collateral network involvement associated with development of truncal (systematized) versus diffuse/non-truncal (non-systematized) varicose veins (VVs) in patients undergoing endovascular laser photothermolysis for chronic venous insufficiency (CVI). Secondly, we aimed to assess whether the type of VVs influenced the procedural complications of endovascular laser therapy. A total of 508 patients with hydrostatic VVs of the lower limbs who underwent endovenous laser treatment were included, out of which 84. Read More

Eur J Clin Microbiol Infect Dis 2019 May 28;38(5):977-983. Epub 2019 Mar 28.

Unit of Infectious Diseases, Instituto de Investigación Hospital "12 de Octubre" (imas12), University Hospital "12 de Octubre", Avenida de Córdoba, s/n, 28041, Madrid, Spain.

CoNS is the main cause of catheter-related bloodstream infections (CRBSI). Current guidelines recommend catheter withdrawal followed by antibiotics for at least 5 days. We aimed to assess the efficacy and safety of a shorter course of antibiotherapy in patients with CoNS CRBSI. Read More

Clin Appl Thromb Hemost 2019 Jan-Dec;25:1076029619839150

2 Oakland University William Beaumont School of Medicine, Rochester, MI, USA.

Catheter-related (CR) thrombosis is a significant complication of midline catheters (MCs) and peripherally inserted central catheters (PICCs). Limited existing data for MCs suggest a favorable complication profile for MCs. To compare incidence of CR thrombosis between MCs and PICCs and to evaluate the impact of quantity of lumens and catheter diameter on CR thrombosis. Read More

Arch Med Sci 2019 Mar 4;15(2):393-401. Epub 2019 Mar 4.

Department of Vascular Disease, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Introduction: Little is known about pathogenetic mechanisms of superficial venous thrombosis (SVT). We aimed to investigate the systemic inflammatory response in the acute phase of SVT, the time course of inflammatory markers and involvement of inflammation in resolution of thrombus in SVT.

Material And Methods: The circulatory inflammatory parameters high-sensitivity C-reactive protein (hsCRP), tumor necrosis factor α (TNF-α), interleukins 6, 8 and 10 (IL-6, IL-8, IL-10), and markers of fibrinolytic activity tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1) and fibrinogen were determined in 68 patients with acute SVT of lower limbs, who were allocated to two groups, dalteparin 5000 IU once daily or 10 000 IU once daily. Read More

N Engl J Med 2019 Mar;380(12):e16

University of Manitoba, Winnipeg, MB, Canada

Gynecol Obstet Fertil Senol 2019 Mar 16. Epub 2019 Mar 16.

Pôle Femme Mère nouveau-né, University Lille, CHU Lille, 59000 Lille, France; Épidémiologie et qualité des soins, University Lille, EA 2694, 59000 Lille, France.

Postpartum endometritis accounts for 2% of postpartum infections in developed countries. In France, 2.3% of deaths are attributed to puerperal infections. Read More

Z Rheumatol 2019 Mar 14. Epub 2019 Mar 14.

Faculty of Behavioral, Management and Social Sciences, Department Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.

Hughes-Stovin syndrome (HSS), characterized by the combination of multiple pulmonary artery aneurysms and deep vein thrombosis, is a rare and an under-recognized clinical entity with less than 40 published cases in English medical literature. Vascular venous thrombotic events, as occurring in the course of Behçet's disease (BD), are also described in HSS, e. g. Read More

PLoS One 2019 13;14(3):e0213754. Epub 2019 Mar 13.

University of Groningen, University Medical Center Groningen, Department of Critical Care, Groningen, The Netherlands.

Common methods to detect phlebitis may not be sufficient for patients in the intensive care unit (ICU). The goal of this study was to investigate the feasibility of infrared (IR) thermography to objectively detect phlebitis in adult ICU patients. We included a total of 128 adult ICU-patients in a pilot and subsequent validation study. Read More

Phlebology 2019 Mar 13:268355519835625. Epub 2019 Mar 13.

Academic Vascular Surgical Unit, Hull York Medical School, Hull, UK.

Introduction: Endovenous mechanochemical ablation (MOCA) is an increasingly popular non-thermal non-tumescent technique used to treat axial reflux in patients with superficial venous incompetence. However, the optimal management of varicose tributaries following this technique is unknown and may impact on patient outcomes. This study compares MOCA with concomitant phlebectomy (MOCAP) versus ablation with sequential phlebectomy if required (MOCAS). Read More

HSS J 2019 Feb 8;15(1):84-92. Epub 2019 Jan 8.

2UHealth Sports Medicine Institute, University of Miami Miller School of Medicine, Coral Gables, FL USA.

Background: Given the high prevalence of musculoskeletal conditions in the USA, it is important for orthopedic surgeons to promptly identify patients who may be at risk for opioid misuse.

Questions/purposes: The aim of this literature review was to elucidate various musculoskeletal pathologies and complications, as seen on imaging, that may indicate opioid misuse or opioid use disorder.

Methods: A literature search was conducted using the PubMed, Scopus, and Cochrane Library databases for articles related to imaging findings associated with chronic opioid use or misuse in orthopedic patients. Read More

Thyroid 2019 Apr 8. Epub 2019 Apr 8.

1 Division of Endocrinology, Diabetes, Metabolism, and Nutrition; Mayo Clinic, Rochester, Minnesota.

Background: Severe pretibial myxedema (PTM) can be difficult to manage, highlighting the need to investigate newer therapies. Rituximab (RTX) and intravenous immunoglobulin (IVIg) have been tried in Graves' orbitopathy. Since PTM and orbitopathy share a similar underlying pathophysiology, this study aimed to explore these therapies for progressive PTM. Read More

Curr Oncol 2019 Feb 1;26(1):e115-e118. Epub 2019 Feb 1.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Japan.

Nivolumab, an anti-PD-1 antibody, is now considered an important therapeutic agent in several advanced malignancies. However, immune-related adverse events such as endocrinopathies have been reported with its use. Thyroid disorder and isolated adrenocorticotropic hormone deficiency have frequently been reported as nivolumab-induced immune-related adverse events. Read More

Open Forum Infect Dis 2019 Feb 30;6(2):ofz028. Epub 2019 Jan 30.

Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, School of Medicine, Seattle, Washington.

We retrospectively evaluated off-label use of dalbavancin as secondary therapy in 32 patients with serious infections (endocarditis, osteomyelitis, septic thrombophlebitis, epidural infection) who were also persons who use drugs. The majority of patients (56%) had a clinical response to treatment. Only 1 patient who completed the intended dalbavancin course experienced a treatment failure. Read More

Am J Case Rep 2019 Feb 28;20:263-267. Epub 2019 Feb 28.

Department of Clinical Engineering, Suzuka University of Medical Science, Suzuka, Mie, Japan.

BACKGROUND Clinical presentation of nasopharyngeal carcinoma (NPC) is correlated with the extent of primary and nodal disease. Hence, depending on the anatomical structures affected, the clinical presentation varies accordingly, ranging from non-specific symptoms of epistaxis, unilateral nasal obstruction, and auditory complaints, to cranial nerve palsies. Nodal metastasis in the neck is a frequent clinical finding in nasopharyngeal carcinoma. Read More

Case Rep Infect Dis 2019 21;2019:5341281. Epub 2019 Jan 21.

Department of Infectious Diseases, Presence Saint Francis Hospital, 355 Ridge Avenue, Evanston, IL 60202, USA.

Pylephlebitis is a rare complication of intra-abdominal infections and describes thrombosis and infection as two different pathophysiological phenomena in the cause of this disease. The nonspecific presentation of disease makes its diagnosis difficult and thus leads to high mortality. The treatment comprises antibiotics and also includes controversial use of anticoagulation in these patients. Read More

J Vasc Bras 2018 Oct-Dec;17(4):337-340

Hospital Universitário Evangélico de Curitiba - HUEC, Curitiba, PR, Brasil.

Lemierre syndrome is characterized by septic thrombophlebitis of the internal jugular vein, after an oropharyngeal infection, with septic embolization to the lungs or other organs. This case report describes a 37-year-old female patient who presented with edema and pain in the right hemiface with onset 3 days previously and progressive fatigue and dyspnea since the previous day. She had had tooth 48 extracted 3 days previously. Read More

Aesthetic Plast Surg 2019 Feb 19. Epub 2019 Feb 19.

Adella Aesthetic, 15G, Tintyava Str., 1172, Sofia, Bulgaria.

Mondor's disease is the eponym used to describe a self-limited phlebitis or thrombophlebitis of the superficial veins localized mainly on the thoracoabdominal area of the human body. Its clinical manifestation includes painful superficial cords causing skin retraction. This medical condition could be idiopathic, iatrogenic or a manifestation of underlying pathology such as breast cancer and seems to be more common than has been previously thought. Read More

Indian J Pharmacol 2018 Nov-Dec;50(6):344-349

Department of Anaesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Objectives: Thrombosis and thrombophlebitis of the superficial venous system are common in hospitalized patients. Efficacy and safety of topical quick penetrating solution (QPS) of heparin were compared to heparin sodium topical gel for the prevention of infusion-associated phlebitis.

Materials And Methods: Patients aged 18-65 years undergoing intravenous cannulation for at least 72 h were enrolled and randomized to receive 6-8 drops of topical solution of heparin (Group sodium topical solution [QPS]) or1 g of topical gel (Group GEL) over the cannulated vein every 8 hourly for a total of 10 doses. Read More

ACG Case Rep J 2018 19;5:e99. Epub 2018 Dec 19.

Department of Internal Medicine, Division of Gastroenterology, Detroit Medical Center/Wayne State University, Detroit, MI.

The species is known for its association with septic thrombophlebitis of the internal jugular vein (Lemierre's syndrome). Lemierre's syndrome is associated with septic emboli to the liver and lungs, often causing multiple abscesses. We present a unique case of septicemia in which the bacteria invaded the portal vein through the gastrointestinal mucosa due to diverticulitis and spread hematogenously to the liver and lungs, causing abscesses. Read More

J Stomatol Oral Maxillofac Surg 2019 Feb 14. Epub 2019 Feb 14.

Service de stomatologie et chirurgie maxillo-faciale, CHU de Treichville, BPV3, Abidjan, Cote d'Ivoire.

Lemierre syndrome is a rare, grave and life-threatening disease characterized by a septic thrombophlebitis of the internal jugular vein. Fusobacterium necrophorum is the most causative germ but sometimes others germs can be responsible. The authors report the first published case of Lemierre syndrome caused by a coinfection Levinea sp - Mycobacterium tuberculosis. Read More

Am Surg 2019 Jan;85(1):e47-e49

J Tehran Heart Cent 2018 Jul;13(3):132-135

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Inferior vena cava (IVC) thrombosis is a rare medical condition. Suppurative thrombophlebitis of the IVC is even a more uncommon subtype of IVC thrombosis and is mostly associated with IVC filters or venous catheters. We describe a 66-year-old man with persistent fever and history of pyonephrosis secondary to transurethral lithotripsy 1 month before recent admission. Read More

Heart 2019 Feb 5. Epub 2019 Feb 5.

Department of Cardiology, University Hospital Southampton, Southampton, UK.

Question: Which of the following diagnoses best explains this presentation?Iatrogenic left main stem ostial stenosisSaddle pulmonary embolismMondor's syndrome (thrombophlebitis of superficial veins of chest wall)Coronary thromboembolismEpicardial fat necrosis. Read More

World J Hepatol 2019 Jan;11(1):133-137

Digestive Surgery, Toulouse University Hospital, Toulouse 31400, France.

Background: Caval vein thrombosis after hepatectomy is rare, although it increases mortality and morbidity. The evolution of this thrombosis into a septic thrombophlebitis responsible for persistent septicaemia after a hepatectomy has not been reported to date in the literature. We here report the management of a 54-year-old woman operated for a peripheral cholangiocarcinoma who developed a suppurated thrombophlebitis of the vena cava following a hepatectomy. Read More

Clin Lymphoma Myeloma Leuk 2018 Dec 20. Epub 2018 Dec 20.

Department of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.

Background: The incidence of peripherally inserted central catheter (PICC)-related adverse events has been uncertain in the setting of acute myeloid leukemia (AML) compared with the incidence of centrally inserted central catheter (CICC) adverse events.

Patients And Methods: We conducted a monocentric, randomized trial of patients with previously untreated AML. Of the 93 patients, 46 had received a PICC and 47 had received a CICC as frontline intravascular device. Read More

BMJ Case Rep 2019 Jan 29;12(1). Epub 2019 Jan 29.

Emergency Department, Cork University Hospital Group, Cork, Ireland.

is a rare infection most notable for causing Lemierre's syndrome. This consists of a primary oropharyngeal infection and septic thrombophlebitis, and one or more metastatic focus. Prior to the widespread use of antibiotics, Lemierre's syndrome commonly followed a rapidly progressing course, with a high mortality. Read More

Cochrane Database Syst Rev 2019 01 23;1:CD007798. Epub 2019 Jan 23.

National Centre of Research Excellence in Nursing, Centre for Health Practice Innovation, Menzies Health Institute Queensland, Griffith University, 170 Kessels Road, Brisbane, Queensland, Australia, 4111.

Background: US Centers for Disease Control guidelines recommend replacement of peripheral intravenous catheters (PIVC) no more frequently than every 72 to 96 hours. Routine replacement is thought to reduce the risk of phlebitis and bloodstream infection. Catheter insertion is an unpleasant experience for patients and replacement may be unnecessary if the catheter remains functional and there are no signs of inflammation or infection. Read More

Int J Gynaecol Obstet 2019 Apr 7;145(1):122-123. Epub 2019 Feb 7.

Department of Infectious Diseases, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.

Blood 2019 Feb 14;133(9):906-918. Epub 2019 Jan 14.

Heart Research Institute, Newtown, NSW, Australia.

Thrombosis with associated inflammation (thromboinflammation) occurs commonly in a broad range of human disorders. It is well recognized clinically in the context of superficial thrombophlebitis (thrombosis and inflammation of superficial veins); however, it is more dangerous when it develops in the microvasculature of injured tissues and organs. Microvascular thrombosis with associated inflammation is well recognized in the context of sepsis and ischemia-reperfusion injury; however, it also occurs in organ transplant rejection, major trauma, severe burns, the antiphospholipid syndrome, preeclampsia, sickle cell disease, and biomaterial-induced thromboinflammation. Read More

Blood Coagul Fibrinolysis 2019 Mar;30(2):80-84

Laboratorio de Hematología, Sanatorio Allende.

: Hypodysfibrinogenemia and protein C deficiency are coagulopathies and in this report, we describe a young patient with both defects confirmed by molecular genetic tests. The patient was a 24-year-old woman referred for recurrent thrombophlebitis and finally deep venous thrombosis. Routine coagulation studies revealed mild decrease of protein C (0. Read More

Case Rep Emerg Med 2018 6;2018:7373914. Epub 2018 Dec 6.

M.D., Department of Radiology, Montefiore Medical Center, Bronx, NY, USA.

Lemierre's syndrome is an acute oropharyngeal infection with a secondary septic thrombophlebitis of the internal jugular vein (IVJ) that was first reported in literature in 1936. It involves the progression of disease from a focal suppurative peritonsillar infection to a local septic thrombophlebitis with hematogenous progression to and distant septic emboli. It is a rare and potentially fatal syndrome requiring prompt diagnosis and management. Read More

Quant Imaging Med Surg 2018 Nov;8(10):1039-1051

Department of Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.

Cerebrovascular complications may occur in infectious diseases in the setting of infective endocarditis, central nervous system (CNS) infections, systemic bacteremia and sepsis. Cerebrovascular complications of infections include vasculitis, mycotic aneurysms, and thrombophlebitis. Infectious vasculitis of the CNS may cause cerebral hemorrhage, infarction or ischemia. Read More

Cochrane Database Syst Rev 2018 Dec 31;12:CD004328. Epub 2018 Dec 31.

Royal National Throat, Nose and Ear Hospital, 330 Gray's Inn Road, London, UK, WC1X 8DA.

Background: Epistaxis (nosebleed) most commonly affects children and the elderly. The majority of episodes are managed at home with simple measures. In more severe cases medical intervention is required to either cauterise the bleeding vessel, or to pack the nose with various materials. Read More

Ann Med Surg (Lond) 2019 Jan 22;37:38-41. Epub 2018 Nov 22.

Multi Care Good Samaritan Hospital, Puyallup, WA, USA.

A 49-year-old lady with history of polysubstance use disorder, recurrent cutaneous abscesses, spinal diskitis and septic thrombophlebitis presented to the emergency room with complaints of intermittent fevers, worsening right hip pain and bilateral lower extremity edema. A month before the presentation, she had left another hospital against medical advice after being diagnosed with Methicillin-resistant bacteremia and right hip septic arthritis. Post discharge, she was off antibiotics, but continued heroin and methamphetamine use. Read More

Rev Assoc Med Bras (1992) 2018 Dec;64(12):1117-1121

Cardiovascular Surgery Department, Samsun Traning and Research Hospital, Samsun, Turkey.

Objective: We aimed to evaluate the efficacy of liquid or foam sclerotherapy of varicose veins using venous clinical severity scores and possible complications.

Methods: A total of 318 patients (268 females, 50 males) who were treated with liquid or foam sclerotherapy between January 2012 and December 2012 were included in this study.

Results: Skin necrosis was observed in only 6 patients (1. Read More

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Infectious diseases, Hospital for Tropical Diseases, London, UK.

A young previously healthy patient presented with sepsis and cavitating pneumonia. was isolated from blood cultures and subsequent CT neck showed an internal jugular vein thrombosis. Treatment was with antibiotics, anticoagulation and supportive management. Read More

Health Inf Manag 2018 Dec 18:1833358318819105. Epub 2018 Dec 18.

2 Lancaster University, UK.

Background:: Intracranial venous thrombosis (ICVT) accounts for around 0.5% of all stroke cases. There have been no previously published studies of the International Classification of Diseases, Tenth Edition (ICD-10) validation for the identification of ICVT admissions in adults. Read More

Eur Radiol 2019 May 17;29(5):2716-2723. Epub 2018 Dec 17.

Department of Radiology, College of Medicine, Inha University, Incheon, Republic of Korea.

Objective: To evaluate the impact of subcutaneous tunneling on peripherally inserted central catheter (PICC) placement in terms of central line-associated bloodstream infections (CLABSIs).

Methods: Our dual-facility central institutional review board approved this retrospective study. We compared 302 of 327 consecutive recipients (mean age [± SD], 68. Read More

Int J Cardiol 2019 Mar 6;278:225-231. Epub 2018 Dec 6.

Department of Cardiology, Cardiology I, University Medical Center Mainz, Johannes Gutenberg-University Mainz, Mainz, Germany.

Background: Atherosclerosis is associated with increased cardiovascular mortality. Associations between venous thromboembolism and atherosclerosis were recently reported. We aimed to investigate the impact of symptomatic atherosclerosis on adverse outcomes in patients with pulmonary embolism (PE) and to identify significant differences among patients with PE stratified by symptomatic atherosclerosis. Read More

J Cutan Aesthet Surg 2018 Jul-Sep;11(3):132-135

Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany.

Background: Mondor's disease of the subcutaneous veins of the breast is an uncommon disorder. The etiology of Mondor's disease remains unclear. Usually, it is a self-limited disease. Read More

Case Rep Surg 2018 4;2018:3931674. Epub 2018 Nov 4.

Department of Surgery, Chugoku Rosai Hospital, 1-5-1 Hirotagaya, Kure, Hiroshima 737-0193, Japan.

Pylephlebitis is defined as a septic thrombophlebitis of the portal vein and its tributaries that is associated with multiple suppurative abdominal infections. We report a case of pylephlebitis associated with a cholecystocolonic fistula (CCF). A 41-year-old man presented with upper abdominal pain and anorexia for 1 month. Read More

Case Rep Infect Dis 2018 7;2018:3628395. Epub 2018 Nov 7.

Internal Medicine, Monmouth Medical Center, Long Branch, NJ, USA.

Lemierre's syndrome is a rare disease associated with significant morbidity and mortality. It begins with an oropharyngeal infection, which spreads locally to involve the internal jugular vein causing thrombophlebitis, followed by distant spread and metastatic infections. Affected individuals are commonly young adults. Read More

J Thromb Haemost 2019 Jan 27;17(1):39-51. Epub 2018 Dec 27.

Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA.

Essentials Phlebitis is one of the most frequent complications related to short peripheral catheters (SPC). A new SPC design, aimed for minimizing mechanical phlebitis, was tested in vivo in swine. MRI analysis revealed 40% less inflammation with the new SPC design compared to commercial SPC. Read More

Neurol India 2018 Nov-Dec;66(6):1619-1628

Department of Internal Medicine and Neurology, Neurological Clinic, Trieste, Italy.

Behçet's disease (BD) is a multisystemic vasculitis disorder of almost unknown etiology, which involves small and large vessels and affects both veins and arteries. BD is characterized by recurrent oral aphthae (the main and most recurrent symptoms), genital ulcers, variable skin lesions, arthritis, uveitis, and thrombophlebitis. Other reported symptoms concern the involvement of the gastrointestinal and the central nervous system. Read More

J Clin Pharm Ther 2019 Feb 28;44(1):122-124. Epub 2018 Nov 28.

Touro College of Pharmacy, New York, New York.

What Is Known And Objective: Lemierre's syndrome is often misdiagnosed as a common cold or viral infection. Fusobacterium necrophorum is the most common causative organism. The recommended treatment regimen is 6 weeks of a beta-lactam antibiotic along with metronidazole. Read More