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    Susceptibility-weighted Imaging in Thrombolytic Therapy of Acute Ischemic Stroke.
    Chin Med J (Engl) 2017 Oct;130(20):2489-2497
    Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
    Objective: To provide a comprehensive and latest overview of susceptibility-weighted imaging (SWI) in the application of thrombolysis in acute ischemic stroke, and to update the decision-making effect and clinical value of SWI on identifying stroke patients suitable for thrombolytic therapy and possible benefits and risks followed.

    Data Sources: Literatures referred to this review were collected from PubMed, Medline, and EMBASE published till May 2017, using the search terms including susceptibility-weighted imaging, gradient-echo, T2*, thrombolysis, recombinant tissue plasminogen activator (rt-PA), thrombolytic therapy, and stroke.

    Study Selection: Papers in English or with available English abstracts were considered, with no limitation of study design. Read More

    Use of thrombolytic therapy in DCD liver transplantation does not seem to improve outcome.
    Am J Transplant 2017 Oct 17. Epub 2017 Oct 17.
    Leiden University Medical Center - Surgery, Albinusdreef 2, Leiden, 2333 ZA, Netherlands.
    With great interest we read the article by Bohorquez et al. "Safety and Outcomes in 100 Consecutive Donation After Circulatory Death Liver Transplants Using a Protocol That Includes Thrombolytic Therapy" (1). The authors compared 100 consecutive donation after circulatory death (DCD) liver transplantations (LT) using a protocol that includes thrombolytic therapy (late DCD group) to a historical DCD group (early DCD group) and a cohort of donation after brain death (DBD) LT. Read More

    Comparison of Long-term Outcomes of 50 mg and 100 mg rt-PA in the Management of Acute Pulmonary Thromboembolism.
    Clin Respir J 2017 Oct 17. Epub 2017 Oct 17.
    Department of Pulmonary Diseases, Ataturk University School of Medicine, 25240, Yakutiye, Erzurum, Turkey.
    Background: Pulmonary thromboembolism (PTE) is a life-threatening disease. In this study, we aimed to evaluate long-term outcomes of the use of 50 mg recombinant tissue-type plasminogen activator (rt-PA) in the management of PTE in terms of relapse, pulmonary hypertension (PH), mortality and hemorrhage, and to compare with the use of 100 mg rt-PA.

    Methods: The study was designed as a retrospective cohort. Read More

    The impact of acute kidney injury on in-hospital mortality in acute ischemic stroke patients undergoing intravenous thrombolysis.
    PLoS One 2017 17;12(10):e0185589. Epub 2017 Oct 17.
    Department of Cardiology, County Emergency Hospital Timisoara, Romania, 'Victor Babes' University of Medicine and Pharmacy, Timisoara, Romania.
    Introduction: Acute kidney injury (AKI) increases the risk of death in acute ischemic stroke (AIS) patients. Intravenous thrombolytic therapy (iv. rt-PA) seems to be the most effective treatment for AIS patients. Read More

    Xingnaojing for Moderate-to-severe Acute ischemic Stroke (XMAS): study protocol for a randomized controlled trial.
    Trials 2017 Oct 16;18(1):479. Epub 2017 Oct 16.
    Department of Neurology, Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine, 5 Haiyuncang, Dongcheng District, Beijing, 100029, China.
    Background: Xingnaojing injection (XNJ) is widely used for the treatment of stroke in China. However, there is currently a lack of high-quality evidence of its efficacy for acute ischemic stroke. The main objective of this study is to determine whether the addition of XNJ to standard care improves the 3-month functional outcome in patients with acute ischemic stroke (AIS). Read More

    Visibility of CT Early Ischemic Change Is Significantly Associated with Time from Stroke Onset to Baseline Scan beyond the First 3 Hours of Stroke Onset.
    J Stroke 2017 Sep 29;19(3):340-346. Epub 2017 Sep 29.
    Department of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, New South Wales, Australia.
    Background And Purpose: Non-contrast brain computed tomography (NCCT) remains the most common imaging modality employed to select patients for thrombolytic therapy in acute ischemic stroke. The current study used the Alberta Stroke Program Early CT Score (ASPECTS) to identify early ischemic changes on brain NCCT imaging with the aim to investigate whether a relationship exists between time from symptoms onset to NCCT with the presence of early ischaemic change quantified by ASPECTS.

    Methods: We studied 1,329 ischemic stroke patients who had NCCT within 8 hours of stroke onset. Read More

    Unmet goals in the treatment of Acute Myocardial Infarction: Review.
    F1000Res 2017 27;6. Epub 2017 Jul 27.
    Universidad Católica de Buenos Aires, Buenos Aires, Argentina.
    Reperfusion therapy decreases myocardium damage during an acute coronary event and consequently mortality. However, there are unmet needs in the treatment of acute myocardial infarction, consequently mortality and heart failure continue to occur in about 10% and 20% of cases, respectively. Different strategies could improve reperfusion. Read More

    Surgical Embolectomy for Acute Pulmonary Thromboembolism.
    Ann Vasc Dis 2017 Jun;10(2):107-114
    Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.
    Acute pulmonary thromboembolism is a catastrophic event, especially for hospitalized patients. The prognosis of pulmonary thromboembolism depends on the degree of pulmonary arterial occlusion. The mortality of massive pulmonary embolism is reportedly as high as 25% without cardiopulmonary arrest and 65% with cardiopulmonary arrest. Read More

    Catheter-Directed Therapy for Acute Submassive Pulmonary Embolism: Summary of Current Evidence and Protocols.
    Tech Vasc Interv Radiol 2017 Sep 8;20(3):193-196. Epub 2017 Jul 8.
    Division of Vascular and Interventional Radiology, Stanford University Medical Center, Stanford, CA. Electronic address:
    Treatment of acute submassive pulmonary embolism (PE) with thrombolytic therapy remains an area of controversy. For patients who fail or who have contraindications to systemic thrombolysis, catheter-directed therapy (CDT) may be offered depending on the patient's condition and the available institutional resources to perform CDT. Although various CDT techniques and protocols exist, the most studied method is low-dose catheter-directed thrombolytic infusion without mechanical thrombectomy. Read More

    Systemic Thrombolysis for Pulmonary Embolism: Who and How.
    Tech Vasc Interv Radiol 2017 Sep 5;20(3):162-174. Epub 2017 Jul 5.
    Division of Pulmonary and Critical Care, Pulmonary and Critical Care Medicine, Cardiac Surgery Intensive Care Unit, Cedars-Sinai Medical Center, Los Angeles, CA.
    Anticoagulation has been shown to improve mortality in acute pulmonary embolism (PE). Initiation of anticoagulation should be considered when PE is strongly suspected and the bleeding risk is perceived to be low, even if acute PE has not yet been proven. Low-risk patients with acute PE are simply continued on anticoagulation. Read More

    Pulmonary Embolism in 2017: How We Got Here and Where Are We Going?
    Tech Vasc Interv Radiol 2017 Sep 5;20(3):128-134. Epub 2017 Jul 5.
    Jefferson Vascular Center, Sidney Kimmel Medical College, Thomas Jefferson University Hospitals, Philadelphia, PA. Electronic address:
    In the 1970s, both the Urokinase Pulmonary Embolism and Urokinase-Streptokinase Pulmonary Embolism trials began the quest to develop thrombolytic therapy for the treatment of acute massive and submassive pulmonary embolism (PE). The goals of these studies were the immediate reduction in clot burden, restoration of hemodynamic stability, and improved survival. Major bleeding became the major barrier for clinicians to employ these therapies. Read More

    Arterial Thrombus Stability: Does It Matter and Can We Detect It?
    J Am Coll Cardiol 2017 Oct;70(16):2036-2047
    Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York.
    The spontaneous lysis of a coronary thrombus is a natural protective mechanism against lasting occlusion and downstream infarction. Thrombus stability is thus a direct determinant of clinical outcome. Compared with the extensive study of the crucial role of platelets, coagulation, and flow in arterial thrombosis, little attention has been paid to factors affecting thrombus stability, despite evidence linking impaired spontaneous fibrinolytic activity with acute coronary events. Read More

    Anterograde injection of low-dose urokinase salvages free anterolateral thigh flap: A case report of safe and effective treatment.
    Medicine (Baltimore) 2017 Oct;96(41):e7932
    Department of Plastic Surgery, China Medical University Hospital, Taichung, Taiwan.
    Rationale: A 54-year-old Taiwanese male came to our hospital presented with right retromolar mucoepidermoid carcinoma. Composite resection and right modified radical neck dissection were performed. We then use free anteral lateral thigh flap to reconstruct the defect. Read More

    Predictive value of depression and anxiety for long-term mortality: differences in outcome between acute coronary syndrome and stable angina pectoris.
    Int J Cardiol 2017 Oct 6. Epub 2017 Oct 6.
    Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands; Research Institute of Child Development and Education, University of Amsterdam/de Bascule-AMC, The Netherlands.
    Background: Since the early 2000s the treatment of choice for an acute myocardial infarction has moved from thrombolytic therapy to primary PCI (pPCI). As a result, the majority of patients undergoing PCI shifted from stable angina pectoris (SA) to acute coronary syndrome (ACS). Additionally the previously observed association between depression and anxiety and long-term outcome in patients who underwent a PCI may have been changed. Read More

    Cannabis can augment thrombolytic properties of rtPA: Case report of an intracranial hemorrhage in a heavy cannabis user.
    Am J Emerg Med 2017 Sep 28. Epub 2017 Sep 28.
    Mercer University School of Medicine, 707, Pine St, Macon, GA 31201, United States. Electronic address:
    Cannabis is one of the most commonly used illicit drugs in the United States and is considered to have several adverse health effects. There is evidence suggesting that its recreational use is associated with both increased cardio- and cerebrovascular events. Recently, multiple cases of ischemic and hemorrhagic strokes associated with cannabis use were reported in the literature (Goyal et al. Read More

    Ischemic Stroke: Advances in Diagnosis and Management.
    Emerg Med Clin North Am 2017 Nov;35(4):911-930
    Mount Sinai Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, Box 1620, New York, NY 10128, USA. Electronic address:
    Acute ischemic stroke carries the risk of morbidity and mortality. Since the advent of intravenous thrombolysis, there have been improvements in stroke care and functional outcomes. Studies of populations once excluded from thrombolysis have begun to elucidate candidates who might benefit and thus should be engaged in the process of shared decision-making. Read More

    Acute Limb Ischemia: An Emergency Medicine Approach.
    Emerg Med Clin North Am 2017 Nov 23;35(4):889-909. Epub 2017 Aug 23.
    Department of Emergency Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792, USA; Emergency Department, Beloit Memorial Hospital, 1969 W Hart Road, Beloit, WI 53511, USA. Electronic address:
    Acute limb ischemia is a medical emergency with significant morbidity and mortality. Rapid diagnosis is required because it is a time-sensitive condition. Timely treatment is necessary to restore blood flow to the extremity and prevent complications. Read More

    Deep Venous Thrombosis.
    Emerg Med Clin North Am 2017 Nov 23;35(4):743-770. Epub 2017 Aug 23.
    Emergency Medicine Residency Program, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA 17822-2005, USA.
    Deep venous thrombosis (DVT) is a frequently encountered condition that is often diagnosed and treated in the outpatient setting. Risk stratification is helpful and recommended in the evaluation of DVT. An evidence-based diagnostic approach is discussed here. Read More

    Extracranial Cervical Artery Dissections.
    Emerg Med Clin North Am 2017 Nov 23;35(4):727-741. Epub 2017 Aug 23.
    Department of Emergency Medicine, University of Texas-Southwestern, Parkland Hospital, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address:
    Cervical artery dissections (CeAD) include both internal carotid and vertebral artery dissections. They are rare but important causes of stroke, especially in younger patients. CeAD should be considered in patients with strokelike symptoms, a new-onset headache and/or neck pain, and/or other risk factors. Read More

    The importance of atrial fibrillation and selected echocardiographic parameters for the effectiveness and safety of thrombolytic therapy in patients with stroke.
    Neurol Neurochir Pol 2017 Sep 19. Epub 2017 Sep 19.
    Department of Neurology, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Poland.
    Background: The efficacy and safety of thrombolytic therapy in stroke depend on multiple factors. The aim of this study was to evaluate the significance of atrial fibrillation the prognosis in terms of the functional status in patients with stroke treated with intravenous thrombolysis. An additional aim was also to assess the potential significance of reduced ejection fraction (EF) and enlarged left atrium (LA) of the heart for the prognosis in patients with stroke who underwent thrombolytic therapy. Read More

    Pharmacological thrombolysis for acute ischemic stroke treatment: Gender differences in clinical risk factors.
    Adv Med Sci 2017 Oct 3;63(1):100-106. Epub 2017 Oct 3.
    Greenville Health System, SC, USA. Electronic address:
    Background: In a stroke population, women have a worse outcome than men when untreated. In contrast, there is no significant difference in treated patients. In this study, we determined whether clinical variables represent a promising approach to assist in the evaluation of gender differences in a stroke population. Read More

    Blood pressure and in-hospital outcomes in patients presenting with ischaemic stroke.
    Eur Heart J 2017 Oct;38(37):2827-2835
    Brigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, 75 Francis Street, Boston 02115, MA, USA.
    Aims: Post-stroke hypertension is associated with poor short-term outcome, although the results have been conflicting. Our objective was to evaluate the association of blood pressure (BP) and in-hospital outcomes in patients with acute ischaemic stroke.

    Methods And Results: Patients in the Get With The Guidelines-Stroke registry with acute ischaemic stroke were included. Read More

    Comparison of the Ecarin Chromogenic Assay and Diluted Thrombin Time for Quantification of Dabigatran Concentrations.
    J Thromb Haemost 2017 Oct 4. Epub 2017 Oct 4.
    Thrombosis and Atherosclerosis Research Institute, McMaster University.
    Background: Although routine coagulation monitoring is unnecessary, measuring plasma dabigatran concentrations can be useful for detecting drug accumulation in renal failure or overdose, assessing the contribution of dabigatran to serious bleeding, planning the timing of urgent surgery or intervention; or determining the suitability for thrombolytic therapy for acute ischemic stroke. Dabigatran concentrations can be quantified using chromogenic or clot-based tests, such as the ecarin chromogenic assay (ECA) and the diluted thrombin time (dTT), respectively.

    Objectives: The purpose of this study was to compare the results of these assays with dabigatran concentrations measured by the gold-standard of mass spectrometry in samples from 50 dabigatran-treated patients collected at peak and trough after at least 4 months of drug intake. Read More

    Promoting Neurovascular Recovery in Aged Mice after Ischemic Stroke - Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids.
    Aging Dis 2017 Oct 1;8(5):531-545. Epub 2017 Oct 1.
    1State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, and Collaborative Innovation Center, Fudan University, Shanghai 200032, China.
    The aged population is among the highest at risk for ischemic stroke, yet most stroke patients of advanced ages (>80 years) are excluded from access to thrombolytic treatment by tissue plasminogen activator, the only FDA approved pharmacological therapy for stroke victims. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) robustly alleviate ischemic brain injury in young adult rodents, but have not yet been studied in aged animals. This study investigated whether chronic dietary supplementation of n-3 PUFAs protects aging brain against cerebral ischemia and improves long-term neurological outcomes. Read More

    Veno-Arterial Extracorporeal Membrane Oxygenation with Conventional Anticoagulation Can Be a Best Solution for Shock Due to Massive PE.
    Int Heart J 2017 Sep 30. Epub 2017 Sep 30.
    Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
    While most of pulmonary thromboembolism (PE) cases can be managed by thrombolytic and anticoagulation therapy, massive PE remains a life-threatening disease. Although surgical embolectomy can be a curative therapy for massive PE, peri-operative mortality for hemodynamically collapsed PE is extremely high. We present a case of hemodynamically collapsed massive PE. Read More

    Justification of routine venous thromboembolism prophylaxis in head and neck cancer reconstructive surgery.
    Head Neck 2017 Sep 30. Epub 2017 Sep 30.
    Department of Oral and Maxillofacial - Head and Neck Oncology, Shanghai Ninth People's Hospital, Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Background: Venous thromboembolism (VTE) is a preventable complication in which early ambulation is expected after head and neck surgery. Thus, the role of VTE prophylaxis is questionable and needs further assessment. The purpose of this study was to specify the relative contributing risk factors for patients who underwent head and neck cancer ablation with immediate reconstruction. Read More

    Review of acute ischaemic stroke in Pakistan: progress in management and future perspectives.
    Stroke Vasc Neurol 2017 Mar 24;2(1):30-39. Epub 2017 Feb 24.
    Department of Neurology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan.
    Ischaemic stroke is a major cause of neurological morbidity and mortality. The objective of this review article is to summarise facts pertaining to acute ischaemic stroke and its various aspects in a developing country like Pakistan, where resources are limited and the healthcare system is underdeveloped. No large-scale epidemiological studies are available to determine the true incidence of stroke in Pakistan. Read More

    A case of cerebral embolism with a large thrombus in the left atrium, and a recurrence of thrombus in the left atrium after the maze procedure.
    Rinsho Shinkeigaku 2017 Sep 28. Epub 2017 Sep 28.
    Department of Neurological Science, Graduate School of Medicine, Nippon Medical School.
    A 67-year-old woman developed weakness of the entire left side of the body and disturbance of consciousness, and was admitted to our hospital. She had atrial fibrillation (AF) on arrival at the hospital. Diffusion weighted magnetic resonance imaging showed high intensity area in the right basal ganglia, and magnetic resonance angiography showed occlusion of the right internal carotid artery (ICA). Read More

    Hybrid method in severe pulmonary embolism not suitable for systemic fibrinolysis.
    Asian Cardiovasc Thorac Ann 2017 Jan 1:218492317735722. Epub 2017 Jan 1.
    Department of Radiology, 66400 Princess Margaret Hospital, Hong Kong.
    Acute massive pulmonary embolism is known to be associated with high mortality, and treatment options may be limited if systemic fibrinolysis is contraindicated. We report the exciting results of a novel mechanical-pharmacological hybrid approach in 3 patients with life-threatening massive pulmonary embolism, in whom systemic fibrinolysis was contraindicated. Read More

    Echocardiographic assessment with right ventricular function improvement following ultrasound-accelerated catheter-directed thrombolytic therapy in submassive pulmonary embolism.
    Vascular 2017 Jan 1:1708538117733645. Epub 2017 Jan 1.
    1 Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
    Introduction The objective of this study was to evaluate the efficacy of ultrasound-accelerated catheter-directed thrombolytic therapy in patients with submassive pulmonary embolism. Methods Clinical records of 46 patients with submassive pulmonary embolism who underwent ultrasound-accelerated catheter-directed pulmonary thrombolysis using tissue plasminogen activator, from 2007 to 2017, were analyzed. All patients experienced clinical symptoms with computed tomography evidence of pulmonary thrombus burden. Read More

    Tissue plasminogen activator-based nanothrombolysis for ischemic stroke.
    Expert Opin Drug Deliv 2017 Sep 28:1-12. Epub 2017 Sep 28.
    a Department of Neurosurgery , Pennsylvania State University College of Medicine , Hershey , PA , USA.
    Introduction: Thrombolysis with intravenous tissue plasminogen activator (tPA) is the only FDA approved treatment for patients with acute ischemic stroke, but its use is limited by narrow therapeutic window, selective efficacy, and hemorrhagic complication. In the past two decades, extensive efforts have been undertaken to extend its therapeutic time window and explore alternative thrombolytic agents, but both show little progress. Nanotechnology has emerged as a promising strategy to improve the efficacy and safety of tPA. Read More

    Prevention of Left Ventricular Thrombus Formation and Systemic Embolism After Anterior Myocardial Infarction: A Systematic Literature Review.
    Can J Cardiol 2017 Oct 1;33(10):1229-1236. Epub 2017 Aug 1.
    Cardiology Service, Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada; Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada. Electronic address:
    Background: Anterior myocardial infarction (MI) with apical dysfunction is associated with an increased risk of left ventricular thrombus (LVT) formation and systemic embolism (SE). However, the role for prophylactic anticoagulation in current practice is a matter of debate.

    Methods: We conducted a systematic review of peer-reviewed original articles in either English or French on the benefit of combining anticoagulation with standard therapy for the prevention of LVT/SE after MI by searching PubMed, Ovid/MedLine/Embase, the Cochrane Library, and Google Scholar. Read More

    Effects of ticagrelor versus clopidogrel on platelet function in fibrinolytic-treated STEMI patients undergoing early PCI.
    Am Heart J 2017 Oct 20;192:105-112. Epub 2017 Jul 20.
    Terrence Donnelly Heart Centre, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
    Objectives: Patients undergoing PCI early after fibrinolytic therapy are at high risk for both thrombotic and bleeding complications. We sought to assess the pharmacodynamic effects of ticagrelor versus clopidogrel in the fibrinolytic-treated STEMI patients undergoing early PCI.

    Methods And Results: Patients undergoing PCI within 24 hours of tenecteplase (TNK), aspirin, and clopidogrel for STEMI were randomized to receive additional clopidogrel 300 mg followed by 75 mg daily or ticagrelor 180 mg followed by 90 mg twice daily. Read More

    Cloning, expression, purification and bioactivity evaluation of a thrombin-like enzyme from Deinagkistrodon acutus venom gland library.
    Biotechnol Lett 2017 Sep 21. Epub 2017 Sep 21.
    School of Pharmacy, Second Military Medical University, Shanghai, 200433, China.
    Objectives: To identify a new member of serine proteases from Deinagkistrodon acutus via phage display technique and appraise its biocatalytic activities.

    Results: A novel thrombin-like enzyme gene was cloned by screening the phage display library of D. acutus venom gland. Read More

    Sex-related differences in the risk factors for in-hospital mortality and outcomes of ischemic stroke patients in rural areas of Taiwan.
    PLoS One 2017 21;12(9):e0185361. Epub 2017 Sep 21.
    Department of Neurology, Chia-Yi Christian Hospital, Chia-Yi, Taiwan.
    Background And Purpose: Sex-related differences in the clinical presentation and outcomes of stroke patients are issues that have attracted increased interest from the scientific community. The present study aimed to investigate sex-related differences in the risk factors for in-hospital mortality and outcome in ischemic stroke patients.

    Methods: A total of 4278 acute ischemic stroke patients admitted to a stroke unit between January 1, 2007 and December 31, 2014 were included in the study. Read More

    Pharmacists as Care Providers for Stroke Patients: A Systematic Review.
    Can J Neurol Sci 2017 Sep 20:1-7. Epub 2017 Sep 20.
    1Faculty of Pharmacy and Pharmaceutical Sciences,University of Alberta,Edmonton,Alberta,Canada.
    Background: Pharmacists have become an integral member of the multidisciplinary team providing clinical patient care in various healthcare settings. Although evidence supporting their role in the care of patients with other disease states is well-established, minimal literature has been published evaluating pharmacist interventions in stroke patients. The purpose of this systematic review is to summarize the evidence evaluating the impact of pharmacist interventions on stroke patient outcomes. Read More

    Enterprise stent in recanalizing non-acute atherosclerotic intracranial internal carotid artery occlusion.
    Clin Neurol Neurosurg 2017 Jun 27;162:47-52. Epub 2017 Jun 27.
    Department of Neurosurgery, The Second Hospital of Shandong University, Jinan 250033, Shandong, China. Electronic address:
    Objective: To investigate the safety and effectiveness of recanalization in non-acute occlusion of intracranial internal carotid arteries using the flexible Enterprise self-expanding stent.

    Patients And Methods: From June 2014 to June 2016, 12 consecutive patients with non-acute occlusion of intracranial internal carotid arteries received endovascular recanalization with Enterprise stenting. All patients received medication for anti-platelet aggregation therapy before and after the operation. Read More

    Predictors of post-thrombolysis symptomatic intracranial hemorrhage in Chinese patients with acute ischemic stroke.
    PLoS One 2017 18;12(9):e0184646. Epub 2017 Sep 18.
    Center of Stroke, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
    Background And Purpose: Predictors of symptomatic intracranial hemorrhage (sICH) in Chinese patients with acute ischemic stroke treated with recombinant tissue plasminogen activator remain unclear.

    Methods: Data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China) study were assessed to explore risk factors for symptomatic intracranial hemorrhage after intravenous thrombolysis. Three candidate sICH definitions were analyzed. Read More

    Pulmonary embolism severity assessment and prognostication.
    Thromb Res 2017 Sep 8. Epub 2017 Sep 8.
    Respiratory Department, Ramón y Cajal Hospital, IRYCIS, Alcala de Henares University, Madrid, Spain. Electronic address:
    For patients who have acute symptomatic pulmonary embolism (PE), risk of short-term death and adverse outcomes should drive the initial treatment decisions. Practice guidelines recommend that patients who have a high-risk of PE-related death and adverse outcomes, determined by the presence of haemodynamic instability (i.e. Read More

    The role of specialized prevention clinics for the short term follow-up of acute coronary syndromes.
    Turk Kardiyol Dern Ars 2017 Sep;45(6):498-505
    Department of Cardiology, Nizip State Hospital, Gaziantep, Turkey.
    Objective: This study aimed to investigate the effect of specialized prevention clinics and standard clinics follow-ups on secondary protection after acute coronary syndrome (ACS) on cardiovascular risk factors.

    Methods: A total of 118 patients who received thrombolytic therapy after being diagnosed with ST-segment elevation myocardial infarction were followed up for 6 months. After ACS, patients in a specialized prevention clinic (Group 1) (n=67) and those in a standard clinic (Group 2) (n=51) were compared in terms of the change in their lifestyle, management of risk factors, and drug compliance. Read More

    Endothelial Progenitor Cells for Ischemic Stroke: Update on Basic Research and Application.
    Stem Cells Int 2017 16;2017:2193432. Epub 2017 Aug 16.
    Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
    Ischemic stroke is one of the leading causes of human death and disability worldwide. So far, ultra-early thrombolytic therapy is the most effective treatment. However, most patients still live with varying degrees of neurological dysfunction due to its narrow therapeutic time window. Read More

    [Endovascular thrombectomy for ischemic stroke].
    Med Klin Intensivmed Notfmed 2017 Sep 11. Epub 2017 Sep 11.
    Klinik für Neurologie, Universitätsklinikum Essen, Hufelandstraße 55, 45147, Essen, Deutschland.
    The standard of care for patients with acute stroke of the anterior circulation and large vessel occlusion is the combined treatment with intravenous rt-PA (recombinant tissue-type plasminogen activator) and endovascular thrombectomy. The therapy is highly effective while reducing functional deficits and long-term disability. International guidelines recommend thrombectomy during the first 6 h after symptom onset, but new evidence supports its use in selected patients within a time window of up to 24 h. Read More

    CSF inflammatory response after intraventricular hemorrhage.
    Neurology 2017 Oct 8;89(15):1553-1560. Epub 2017 Sep 8.
    From the Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery (M.D.F., H.A.Z., J.K.E., A.S., M.J., Y.C., M.W., L.Z., Y.C., M.W., L.Z., I.A.A.), University of Chicago Medicine and Biological Sciences, IL; Brain Injury Outcomes (BIOS) Division, Department of Neurology (N.M., K.L., W.Z., D.F.H.), and The Bloomberg School of Public Health (R.E.T.), Johns Hopkins University Medical Institutions, Baltimore, MD; and Department of Neurology (S.J.), Rush University Medical Center, Chicago, IL.
    Objective: To investigate the temporal pattern and relevant associations of CSF inflammatory measures after intraventricular hemorrhage (IVH).

    Methods: We analyzed prospectively collected CSF cell counts and protein and glucose levels from participants in the Clot Lysis Evaluation of Accelerated Resolution of IVH phase III (CLEAR III) trial. Corrected leukocyte count and cell index were calculated to adjust for CSF leukocytes attributable to circulating blood. Read More

    Outcome of Patients Receiving Thrombolytic Therapy While on Rivaroxaban for Nonvalvular Atrial Fibrillation (from Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation).
    Am J Cardiol 2017 Aug 7. Epub 2017 Aug 7.
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina. Electronic address:
    The safety of intravenous thrombolysis in patients taking rivaroxaban has not been well established. We retrospectively analyzed the outcomes of all patients who received thrombolytic therapy in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF). A review of medical and adverse event records for patients receiving thrombolytic therapy while enrolled in ROCKET AF was performed to determine their baseline characteristics, indications for thrombolysis, and type of agent used. Read More

    Comparison of In-Hospital Outcomes and Readmission Rates in Acute Pulmonary Embolism Between Systemic and Catheter-Directed Thrombolysis (from the National Readmission Database).
    Am J Cardiol 2017 Nov 31;120(9):1653-1661. Epub 2017 Jul 31.
    Department of Cardiology, Detroit Medical Center, Detroit, Michigan.
    There are sparse comparative data on in-hospital outcomes and readmission rates in patients with acute pulmonary embolism (PE) who receive systemic thrombolytics versus catheter-directed thrombolysis (CDT). The study cohort was derived from the National Readmission Database 2013 to 2014, subset of the Healthcare Cost and Utilization Project sponsored by the Agency for Healthcare Research and Quality. Systemic and CDT were identified using appropriate International Classification of Diseases, 9th Revision, Clinical Modification codes. Read More

    Efficacy and Safety of Ticagrelor Over Time in Patients With Prior MI in PEGASUS-TIMI 54.
    J Am Coll Cardiol 2017 Sep;70(11):1368-1375
    TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts.
    Background: Ticagrelor reduces ischemic risk in patients with prior myocardial infarction (MI). It remains unclear whether ischemic risk and the benefits of prolonged P2Y12 inhibition in this population remain consistent over time.

    Objectives: The study sought to investigate the pattern of ischemic risk over time and whether the efficacy and safety of ticagrelor were similar early and late after randomization. Read More

    Elongated Plant Virus-Based Nanoparticles for Enhanced Delivery of Thrombolytic Therapies.
    Mol Pharm 2017 Sep 26. Epub 2017 Sep 26.
    Department of Biomedical Engineering, Case Western Reserve University , Cleveland, Ohio 44106, United States.
    Thrombotic cardiovascular disease, including acute myocardial infarction, ischemic stroke, and venous thromboembolic disease, is the leading cause of morbidity and mortality worldwide. While reperfusion therapy with thrombolytic agents reduces mortality from acute myocardial infarction and disability from stroke, thrombolysis is generally less effective than mechanical reperfusion and is associated with fatal intracerebral hemorrhage in up to 2-5% of patients. To address these limitations, we propose the tobacco mosaic virus (TMV)-based platform technology for targeted delivery of thrombolytic therapies. Read More

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