30,935 results match your criteria Thrombolytic Therapy


Analysis of the Association Between Polymorphisms within PAI-1 and ACE genes and Ischemic Stroke Outcome After rt-PA Therapy.

J Pharm Pharm Sci 2019 ;22(1):142-149

Institute of Human Genetics, Faculty of Medicine, University of Belgrade, Serbia.

Purpose: Treatment of Ischemic stroke (IS) in acute phase is based on the use of thrombolytic rt-PA therapy. We aimed to determine whether different alleles and genotypes of I/D ACE gene and 4G/5G PAI-1 gene polymorphisms may influence outcome of rt-PA therapy in patients with IS and the occurrence of haemorrhagic transformation (HT).

Methods: Our study included 94 consecutive patients with IS treated with rt-PA. Read More

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http://dx.doi.org/10.18433/jpps30339DOI Listing
January 2019

Cost-effectiveness of mechanical thrombectomy using stent retriever after intravenous tissue plasminogen activator compared with intravenous tissue plasminogen activator alone in the treatment of acute ischaemic stroke due to large vessel occlusion in Spain.

Eur Stroke J 2017 Sep 1;2(3):272-284. Epub 2017 Aug 1.

Hospital Universitari Germans Trias i Pujol, Badalona, Spain.

Introduction: To assess the cost-effectiveness of stent-retriever mechanical thrombectomy and intravenous tissue plasminogen activator compared with intravenous tissue plasminogen activator alone in patients with acute ischaemic stroke due to large vessel occlusions in Spain.

Materials And Methods: Clinical data were taken from the SWIFT PRIME clinical trial. A lifetime Markov state transition model defined by the modified Rankin Scale score was developed to estimate costs and health outcomes (life years gained and quality adjusted life years). Read More

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http://dx.doi.org/10.1177/2396987317721865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454829PMC
September 2017

Theophylline as an add-on to thrombolytic therapy in acute ischaemic stroke (TEA-Stroke): A randomized, double-blinded, placebo-controlled, two-centre phase II study.

Eur Stroke J 2016 Dec 14;1(4):248-254. Epub 2016 Oct 14.

Department of Neurology, Aalborg University Hospital, Aalborg, Denmark.

Introduction: Early reperfusion of brain tissue at risk of injury (penumbra salvage) is crucial in treating acute ischaemic stroke. Neuroprotective agents may extend the time window for the reperfusion. The vasoactive agent theophylline redistributes the perfusion to ischaemic brain tissue and thus reduces brain damage, brain tissue oedema and mortality in animal stroke models. Read More

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http://dx.doi.org/10.1177/2396987316674542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301252PMC
December 2016

Thrombolysis for Management of Phlegmasia Cerulea Dolens in the First Trimester of Pregnancy.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Surgery, Northwest Community Hospital, Arlington Heights IL.

Introduction: Pregnancy is a hypercoagulable state associated with a fivefold increase in risk of venous thromboembolism. Thrombolysis is the preferred level of care for patients with acute ilio-femoral deep vein thrombosis, however most studies exclude pregnant patients, highlighting the lack of data regarding the efficacy and safety of thrombolytic therapy for the mother and fetus.

Case Report: We describe successful use of thrombolytic therapy in conjunction with ultrasound to remove a large ileo-femoral deep vein thrombosis (DVT) in a first trimester patient with phlegmasia cerulea dolens. Read More

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http://dx.doi.org/10.1016/j.avsg.2019.01.018DOI Listing

Study of Ischemia Modified Albumin as a Biomarker in Acute Ischaemic Stroke.

Ann Neurosci 2018 Dec 28;25(4):187-190. Epub 2018 Jun 28.

Narayana Medical College and Hospitals, Nellore, India.

Background And Purpose: Stroke is one of the leading causes of mortality and long-term disability. Prompt diagnosis and treatment of stroke are crucial for a better outcome. A blood test, which serves as a biomarker in rural areas will help in immediately transferring patients to a hospital for thrombolytic therapy. Read More

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http://dx.doi.org/10.1159/000488188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470340PMC
December 2018

Protease-independent action of tissue plasminogen activator in brain plasticity and neurological recovery after ischemic stroke.

Proc Natl Acad Sci U S A 2019 Apr 17. Epub 2019 Apr 17.

Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh, Pittsburgh, PA 15213;

Emerging evidence suggests that tissue plasminogen activator (tPA), currently the only FDA-approved medication for ischemic stroke, exerts important biological actions on the CNS besides its well-known thrombolytic effect. In this study, we investigated the role of tPA on primary neurons in culture and on brain recovery and plasticity after ischemic stroke in mice. Treatment with recombinant tPA stimulated axonal growth in culture, an effect independent of its protease activity and achieved through epidermal growth factor receptor (EGFR) signaling. Read More

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http://dx.doi.org/10.1073/pnas.1821979116DOI Listing
April 2019
1 Read

[Venous thromboembolic complications in oncological patients: present-day possibilities of effective and safe anticoagulant therapy].

Angiol Sosud Khir 2019 ;25(1):19-23

Department of Surgery, Institute of Additional Professional Education, South Ural State Medical University of the RF Ministry of Public Health, Chelyabinsk, Russia.

Cancer-associated thromboembolic complications in malignant neoplasms are commonly encountered. They deteriorate the course of the underlying disease and are frequent causes of death. The oncological patient is at high risk of not only thrombosis but haemorrhage during anticoagulant therapy. Read More

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http://dx.doi.org/10.33529/angio2019102DOI Listing
January 2019
2 Reads

Comparison of Treatment Result Between Anticoagulation Alone and Catheter-Directed Thrombolysis Plus Anticoagulation in Acute Lower Extremity Deep Vein Thrombosis.

Vasc Specialist Int 2019 Mar;35(1):28-33

Endovascular and Vascular Division, Department of Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.

Purpose: Deep vein thrombosis (DVT) is the third most common cause of cardiovascular morbidity and mortality. Anticoagulation has been the primary treatment modality for acute DVT. However, catheter-directed thrombolysis (CDT) has recently become widely accepted as an additional therapy to anticoagulation. Read More

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http://dx.doi.org/10.5758/vsi.2019.35.1.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453597PMC
March 2019
1 Read

Urban Frostbite: Strategies for Limb Salvage.

J Burn Care Res 2019 Apr 16. Epub 2019 Apr 16.

Section of Plastic and Reconstructive Surgery The Burn and Complex Wound Center The University of Chicago Medicine Chicago, IL.

Introduction: Under ideal circumstances, severely frostbitten extremities are rapidly rewarmed and treated with thrombolytic therapy within 6-24 hours. In an "inner city," urban environment, most patients who suffer frostbite injuries present in a delayed fashion, sustain repeated injuries further complicated by psychological issues or intoxication, and are rarely ideal candidates for thrombolytic therapy within the prescribed timeframe. We describe our experience with the treatment of urban frostbite injuries. Read More

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https://academic.oup.com/jbcr/advance-article/doi/10.1093/jb
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http://dx.doi.org/10.1093/jbcr/irz062DOI Listing
April 2019
1 Read

The association between early neurological deterioration and whole blood purine concentration during acute stroke.

Biomark Res 2019 3;7. Epub 2019 Apr 3.

1NIHR Newcastle Biomedical Research Centre and Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

Background: Early neurological deterioration (END) is common after stroke. Prediction could identify patients requiring additional monitoring and intervention. Purines, breakdown products of adenosine triphosphate which accumulate during acute hypoxia, may reflect the subclinical presence of vulnerable tissue. Read More

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http://dx.doi.org/10.1186/s40364-019-0158-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448300PMC

Comparative efficacy and safety of local and peripheral venous thrombolytic therapy with urokinase for thrombosed hemodialysis arteriovenous fistulas.

Exp Ther Med 2019 May 20;17(5):4279-4284. Epub 2019 Mar 20.

Department of Ultrasonography, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, P.R. China.

Arteriovenous fistula (AVF) thrombosis is a common complication in patients undergoing hemodialysis, and early intervention is required. Urokinase has been used as a thrombolytic agent for declotting the thrombosed access. However, the optimal route for infusing urokinase remains to be determined. Read More

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http://dx.doi.org/10.3892/etm.2019.7415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447926PMC
May 2019
1 Read

Clinical application value of brain CT perfusion imaging in the treatment of acute ischemic stroke thrombolytic therapy.

Exp Ther Med 2019 May 22;17(5):3971-3976. Epub 2019 Mar 22.

Department of Imaging, Liaocheng Brain Hospital, Liaocheng, Shandong 252000, P.R. China.

Clinical application value of CT perfusion (CTP) imaging in the treatment of acute ischemic stroke (AIS) thrombolytic therapy was investigated. Retrospective analysis of 185 suspected AIS patients in Liaocheng Brain Hospital from April 2012 to December 2017 were involved. We observed the non-contrast CT (NCCT) and CTP in the diagnosis of AIS patients, and recorded as well as compared CTP parameters of AIS patients. Read More

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http://dx.doi.org/10.3892/etm.2019.7431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447903PMC
May 2019
1 Read

Protective effects of leptin against cerebral ischemia/reperfusion injury.

Exp Ther Med 2019 May 13;17(5):3282-3290. Epub 2019 Mar 13.

Department of Medical Affairs, Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong 256603, P.R. China.

In recent years, the use of thrombolytic therapy for treating ischemia/reperfusion injury has resulted in damage to the self-regulatory mechanisms of the brain. This is due to the increased production of free radicals, excitatory amino acids and pro-inflammatory cytokines causing secondary damage to the brain. Simple thrombolytic therapy has not been the best approach for treating ischemia/reperfusion injury. Read More

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http://dx.doi.org/10.3892/etm.2019.7377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447799PMC
May 2019
1 Read

Repetitive transient paraplegia caused by painless acute aortic dissection.

Acute Med Surg 2019 Apr 19;6(2):188-191. Epub 2019 Feb 19.

Department of Cardiovascular Surgery Anjo Kosei Hospital Anjo Japan.

Case: Making a precise diagnosis of type A acute aortic dissection (AAD) presenting with atypical symptoms might be challenging for clinicians. Misdiagnosis and misuse of thrombolytic therapy can have devastating consequences.

Outcome: Herein, we report a case of painless type A AAD complicated by transient leg paresthesia, which was successfully treated with surgery. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ams2.392
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http://dx.doi.org/10.1002/ams2.392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442522PMC
April 2019
4 Reads

t-PA Suppresses the Immune Response and Aggravates Neurological Deficit in a Murine Model of Ischemic Stroke.

Front Immunol 2019 27;10:591. Epub 2019 Mar 27.

Molecular Neurotrauma and Haemostasis, Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia.

Acute ischemic stroke (AIS) is a potent trigger of immunosuppression, resulting in increased infection risk. While thrombolytic therapy with tissue-type plasminogen activator (t-PA) is still the only pharmacological treatment for AIS, plasmin, the effector protease, has been reported to suppress dendritic cells (DCs), known for their potent antigen-presenting capacity. Accordingly, in the major group of thrombolyzed AIS patients who fail to reanalyze (>60%), t-PA might trigger unintended and potentially harmful immunosuppressive consequences instead of beneficial reperfusion. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445967PMC
March 2019
1 Read

Synergistic role of susceptibility-weighted imaging with diffusion-weighted imaging and magnetic resonance angiography in the evaluation of acute arterial stroke.

J Int Med Res 2019 Apr 10:300060519840909. Epub 2019 Apr 10.

3 Department of Internal Medicine, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Objective: This study was performed to investigate whether diffusion-weighted imaging (DWI) and susceptibility-weighted imaging (SWI) are more effective than conventional imaging modalities for evaluation of stroke and selection of candidates for thrombolytic therapy.

Methods: Eighty patients who presented within 12 hours of onset of symptoms of brain ischemia underwent 1.5T magnetic resonance imaging. Read More

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http://dx.doi.org/10.1177/0300060519840909DOI Listing
April 2019
1 Read

Post-Stroke Blood-Brain Barrier Disruption and Poor Functional Outcome in Patients Receiving Thrombolytic Therapy.

Cerebrovasc Dis 2019 Apr 10:1-8. Epub 2019 Apr 10.

National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA,

Background And Purpose: The role played by post-stroke inflammation after an ischemic event in limiting functional recovery remains unclear. One component of post-stroke inflammation is disruption of the blood-brain barrier (BBB). This study examines the relationship between post-stroke BBB disruption and functional outcome. Read More

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http://dx.doi.org/10.1159/000499666DOI Listing
April 2019
2 Reads

Accuracy of laboratory tests collected at referring hospitals versus tertiary care hospitals for acute stroke patients.

PLoS One 2019 10;14(4):e0214874. Epub 2019 Apr 10.

Center for Clinical Epidemiology and Clinical Statistics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Background: The standard treatment of acute ischemic stroke patients is thrombolytic therapy within 60 minutes of a patient's arrival in stroke center hospitals. Based on the policy of the Lampang Referral System Committee, blood samples of suspected stroke patients need to be collected before transfer to the stroke center (Lampang Hospital). It was still questionable as to whether these blood samples are valid for clinical use and the present study aimed to confirm or deny their validity. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214874PLOS
April 2019
6 Reads

Management of pulmonary embolism at a large academic hospital.

Proc (Bayl Univ Med Cent) 2019 Jan 16;32(1):9-13. Epub 2018 Nov 16.

Division of Pulmonary and Critical Care Medicine, Baylor University Medical CenterDallasTexas.

The initial management of patients presenting with acute pulmonary embolism (PE) is individualized based on hemodynamic status and other prognostic factors. Patients at low risk of adverse outcomes are treated conservatively with anticoagulation, whereas high-risk and selected intermediate-risk patients should be considered for advanced interventions. Seeking to better understand local practice patterns, we retrospectively reviewed 196 cases of acute PE diagnosed in the emergency department of Baylor University Medical Center over a 12-month period. Read More

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http://dx.doi.org/10.1080/08998280.2018.1503476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442875PMC
January 2019
2 Reads

Prospective Single-Arm Trial of Endovascular Mechanical Debulking as Initial Therapy in Patients With Acute and Subacute Lower Limb Ischemia: One-Year Outcomes.

J Endovasc Ther 2019 Apr 6:1526602819840697. Epub 2019 Apr 6.

1 Cardiocenter, Third Faculty of Medicine, Charles University, and Department of Surgery, Division of Interventional Angiology, University Hospital Královské Vinohrady, Prague, Czech Republic.

Purpose: To report the results of a prospective, single-arm study to establish whether the initial treatment of acute or subacute limb ischemia (ALI and SLI, respectively) can be accomplished successfully using endovascular mechanical debulking of the target vessels to avoid the risks associated with thrombolysis and/or open surgery.

Materials And Methods: From April 2009 to April 2015, 316 consecutive patients (mean age 70.9±12 years; 184 men) with ALI (202, 63. Read More

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http://dx.doi.org/10.1177/1526602819840697DOI Listing
April 2019
1 Read

Usefulness of Inferior Vena Cava Filters in Stable Patients with Acute Pulmonary Embolism.

Am J Cardiol 2019 Mar 14. Epub 2019 Mar 14.

Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan.

Retrospective cohort studies using administrative data from national databases or a registry suggest that there are subcategories of stable patients with acute pulmonary embolism who would show a reduced mortality with an inferior vena cava (IVC) filter in addition to anticoagulants. These subcategories are those who underwent pulmonary embolectomy, receiving thrombolytic therapy, suffering recurrent pulmonary embolism while on treatment, hospitalized with solid malignant tumors if aged >60years, hospitalized with chronic obstructive pulmonary disease (COPD) if aged >50years, and very elderly (aged >80 years). The following is a review of these studies. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.02.054DOI Listing
March 2019
2 Reads

A polysaccharide-based micelle-hydrogel synergistic therapy system for diabetes and vascular diabetes complications treatment.

Mater Sci Eng C Mater Biol Appl 2019 Jul 22;100:94-103. Epub 2019 Feb 22.

State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China. Electronic address:

Various glucose-sensitive drug delivery platforms have been developed recently to treat diabetes. However, there is much less work has been reported on treatment of diabetes and vascular diabetes complications simultaneously. In this work, a novel polysaccharide-based micelle-hydrogel synergistic therapy system was fabricated to address this limitation. Read More

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http://dx.doi.org/10.1016/j.msec.2019.02.081DOI Listing
July 2019
1 Read

Therapeutic strategy against ischemic stroke with the concept of neurovascular unit.

Neurochem Int 2019 Jun 1;126:246-251. Epub 2019 Apr 1.

Department of Neurosurgery, Graduate School of Medicine, Osaka University, Japan.

Stroke is one of the leading causes of death and disability globally. Although thrombolytic therapy by t-PA and mechanical thrombectomy have improved outcomes of ischemic stroke patients, both of these approaches are applicable to limited numbers of patients owing to their time constraints. Therefore, development of other treatment approaches such as developing neuroprotective drugs and nerve regeneration therapy is required to overcome ischemic stroke. Read More

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http://dx.doi.org/10.1016/j.neuint.2019.03.022DOI Listing

Comparative efficacy and safety of bridging strategies with direct mechanical thrombectomy in large vessel occlusion: A systematic review and meta-analysis.

Medicine (Baltimore) 2019 Apr;98(14):e14956

Department of Neurology, Baotou Central Hospital, Baotou, Inner Mongolia, China.

Background: Whether bridging strategies[intravenous thrombolysis (IVT) + mechanical thrombectomy (MT)] are superior to mechanical thrombectomy alone for large vessel occlusion(LVO) is still uncertain. A systematic review and meta-analysis was conducted to investigate and evaluate comparative efficacy and safety of bridging strategies vs direct MT in patients with LVO.

Methods: The PubMed, EMBASE and Cochrane library databases were searched to evaluate the efficacy and safety of bridging strategies with direct MT in LVO. Read More

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http://dx.doi.org/10.1097/MD.0000000000014956DOI Listing
April 2019
1 Read
5.723 Impact Factor

Thrombolysis for atlantoaxial dislocation mimicking acute ischemic stroke: Case report and review.

Am J Emerg Med 2019 Mar 27. Epub 2019 Mar 27.

Stroke Center and Department of Neurology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan. Electronic address:

The frequency of stroke mimics among stroke patients has been reported to be up to 30%, and that in patients who receive thrombolytic therapy ranges between 1% and 16%. Atlantoaxial dislocation with myelopathy mimicking stroke is extremely rare. An 83-year-old man with a history of old cerebellar infarction presented to the emergency department with acute left hemiplegia after a chiropractic manipulation of the neck and back several hours before symptom onset. Read More

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http://dx.doi.org/10.1016/j.ajem.2019.03.044DOI Listing
March 2019
2 Reads

A lung cancer patient with deep vein thrombosis:a case report and literature review.

BMC Cancer 2019 Mar 29;19(1):285. Epub 2019 Mar 29.

Department of Oncology, Affiliated Renji Hospital, Shanghai Jiao Tong University School of Medicine, Pancreatic Cancer Center of Shanghai Jiao Tong University, Shanghai, 200127, China.

Background: Venous thromboembolism (VTE) is a common problem in cancer patients and the incidence is increasing, especially for patients with lung cancer. Common features of these patients, like advanced stage, male gender, old age and chemotherapy, are risk factors of VTE. Here we reported a case in which the patient with lung cancer developed deep vein thrombosis (DVT) when receiving chemotherapy. Read More

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http://dx.doi.org/10.1186/s12885-019-5513-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440012PMC
March 2019
1 Read

Ultrasound-assisted versus conventional catheter-directed thrombolysis for acute pulmonary embolism: A multicenter comparison of patient-centered outcomes.

Vasc Med 2019 Mar 27:1358863X19838334. Epub 2019 Mar 27.

1 Department of Cardiology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY, USA.

Both catheter-directed thrombolysis (CDT) and ultrasound-assisted thrombolysis (USAT) are novel treatment modalities for patients presenting with acute pulmonary embolism (PE). The objective of this study was to compare clinical and quality-of-life (QOL) outcomes for patients undergoing either treatment modality. We retrospectively studied 70 consecutive patients treated with either CDT or USAT over 3 years at a multicenter health system. Read More

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http://journals.sagepub.com/doi/10.1177/1358863X19838334
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http://dx.doi.org/10.1177/1358863X19838334DOI Listing
March 2019
3 Reads
1.732 Impact Factor

Ultrasound-accelerated thrombolysis (USAT) versus standard catheter-directed thrombolysis (CDT) for treatment of pulmonary embolism: A retrospective analysis.

Vasc Med 2019 Mar 27:1358863X19838350. Epub 2019 Mar 27.

1 Department of Cardiovascular Medicine, Beaumont Health, Royal Oak, MI, USA.

Ultrasound-accelerated thrombolysis (USAT) is advocated in pulmonary embolism (PE) based on the hypothesis that adjunctive ultrasound provides superior clinical efficacy compared to standard catheter-directed thrombolysis (CDT). This retrospective study was designed to compare outcomes between the two modalities. We analyzed patients with computed tomography-diagnosed PE at our institution treated with either USAT or standard CDT. Read More

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http://journals.sagepub.com/doi/10.1177/1358863X19838350
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http://dx.doi.org/10.1177/1358863X19838350DOI Listing
March 2019
5 Reads

Preintensive care: Thrombolytic (streptokinase or tenecteplase) in ST elevated acute myocardial infarction at peripheral hospital.

J Family Med Prim Care 2019 Jan;8(1):62-71

Department of Cardiology, Topiwala National Medical College and BYL Nair Hospital, Mumbai, Maharashtra, India.

Background: Coronary artery disease is a major cause of death in India. Sudden death preceded by chest pain is due to acute myocardial infarction. Villagers are aware and afraid of chest pain. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_297_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396635PMC
January 2019
1 Read

Computed Tomography Angiography Findings in Pulmonary Embolism Patients Vary Following Thrombolytic Treatment.

Isr Med Assoc J 2019 Mar;21(3):203-207

Department of Pulmonary Medicine, Meir Medical Center, Kfar Saba, Israel.

Background: Pulmonary embolism (PE) is the third most frequently occurring cardiovascular disease. However, the clinical presentation in patients with PE is variable.

Objectives: To evaluate the prevalence of radiological findings detected in contrast-enhanced computed tomography angiography (CTA) and their significance in patients with PE; and to assess whether the CTA findings differed in patients receiving tissue plasminogen activator (tPA) therapy from those who did not. Read More

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March 2019
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Higher lactate and purine metabolite levels in erythrocyte-rich fresh venous thrombus: Potential markers for early deep vein thrombosis.

Thromb Res 2019 May 14;177:136-144. Epub 2019 Mar 14.

Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.

Background: Thrombolytic therapy is effective in fresh deep vein thrombosis (DVT) although the benefit may fall below the risk of bleeding in non-fresh thrombosis. Markers reflecting fresh DVT have not been established. The present study aims to identify metabolites reflecting fresh venous thrombus and their role in thrombus formation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00493848193015
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http://dx.doi.org/10.1016/j.thromres.2019.03.011DOI Listing
May 2019
5 Reads

Thrombolytic Therapy for Acute Ischemic Stroke: Past and Future.

Curr Pharm Des 2019 Mar 18. Epub 2019 Mar 18.

Division of Pharmacology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy. Japan.

Background: Thromboembolic ischemic stroke, which is mainly caused by hypertension, as well as plasma dyslipidemia, arterial fibrillation and diabetes, is a leading cause of death in the US and other countries. Numerous clinical trials for thrombolytic drugs, which aimed to pharmacologically dissolve thrombi, were conducted from the 1950s, when the first thrombolytic therapy was performed.

Method: We will summarize the pathophysiologic features of ischemic stroke, and the history of thrombolytic therapy, and discuss the recent progress that has been made in the ongoing development of thrombolytic drugs. Read More

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http://dx.doi.org/10.2174/1381612825666190319115018DOI Listing
March 2019
1 Read

Features of Childhood Arterial Ischemic Stroke in China.

Fetal Pediatr Pathol 2019 Mar 19:1-9. Epub 2019 Mar 19.

a Shengjing Hospital of China Medical University , Shenyang , China.

Objective: The aim of this study was to identify the features and risk factors for arterial ischemic stroke (AIS) in children.

Methods: We retrospectively analyzed the initial symptoms, clinical manifestations, risk factors, neuroradiological findings, and treatment data of 75 Chinese children aged between 1 month and 14 years (median 5.7 years) who were diagnosed with AIS in our hospital between 2013 and 2018. Read More

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https://www.tandfonline.com/doi/full/10.1080/15513815.2019.1
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http://dx.doi.org/10.1080/15513815.2019.1588438DOI Listing
March 2019
3 Reads
0.398 Impact Factor

The mean platelet volume on admission predicts unfavorable stroke outcomes in patients treated with IV thrombolysis.

Clin Interv Aging 2019 27;14:493-503. Epub 2019 Feb 27.

Clinic of Neurology, Military Institute of Medicine, Warsaw, Poland,

Purpose: The role of biomarkers in the prediction of acute ischemic stroke (AIS) outcome or response to thrombolytic therapy (with recombinant tissue plasminogen activator [rt-PA]) remains limited. The aim of this study was to evaluate whether mean platelet volume (MPV) could predict short-term functional outcome in patients with AIS following rt-PA treatment.

Patients And Methods: This was a retrospective analysis of 237 AIS patients (mean age 71. Read More

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http://dx.doi.org/10.2147/CIA.S195451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398411PMC
February 2019
3 Reads

Hirudin ameliorates immunoglobulin A nephropathy by inhibition of fibrosis and inflammatory response.

Ren Fail 2019 Nov;41(1):104-112

c Department of Traditional Chinese Medicine , Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital , Chengdu , PR China.

Immunoglobulin A nephropathy (IgAN) is characterized by mesangial IgA and IgG co-deposition. As the clinical course of IgAN is highly variable, a lot of patients will eventually develop to end-stage renal disease (ESRD) within years. Hirudin, a potent and specific thrombin inhibitor, has been reported to treat IgAN with hematuria, but the mechanism is unclear. Read More

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http://dx.doi.org/10.1080/0886022X.2019.1583113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427573PMC
November 2019
7 Reads

Mathematical Modelling of Intravenous Thrombolysis in Acute Ischaemic stroke: Effects of Dose Regimens on Levels of Fibrinolytic Proteins and Clot Lysis Time.

Pharmaceutics 2019 Mar 7;11(3). Epub 2019 Mar 7.

Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.

Thrombolytic therapy is one of the medical procedures in the treatment of acute ischaemic stroke (AIS), whereby the tissue plasminogen activator (tPA) is intravenously administered to dissolve the obstructive blood clot. The treatment of AIS by thrombolysis can sometimes be ineffective and it can cause serious complications, such as intracranial haemorrhage (ICH). In this study, we propose an efficient mathematical modelling approach that can be used to evaluate the therapeutic efficacy and safety of thrombolysis in various clinically relevant scenarios. Read More

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http://dx.doi.org/10.3390/pharmaceutics11030111DOI Listing

Local Ultrasound-Facilitated Thrombolysis in High-Risk Pulmonary Embolism: First Dutch Experience.

Cardiovasc Intervent Radiol 2019 Mar 12. Epub 2019 Mar 12.

Department of Internal Medicine, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands.

Purpose: To provide insight into the current use and results of ultrasound-facilitated catheter-directed thrombolysis (USAT) in patients with high-risk pulmonary embolism (PE).

Introduction: Systemic thrombolysis is an effective treatment for hemodynamically unstable, high-risk PE, but is associated with bleeding complications. USAT is thought to reduce bleeding and is therefore advocated in patients with high-risk PE and contraindications for systemic thrombolysis. Read More

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http://link.springer.com/10.1007/s00270-019-02200-1
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http://dx.doi.org/10.1007/s00270-019-02200-1DOI Listing
March 2019
4 Reads

Thrombolytic Therapy in Cocaine Users with Ischemic Stroke: A Review of Current Practice.

Psychopharmacol Bull 2019 Feb;49(1):70-79

Siniscalchi, MD, Pisani, Department of Neurology, "Annunziata" Hospital, Cosenza, Italy. De Sarro, Gallelli, Department of Health Science, School of Medicine, University of Catanzaro Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini University Hospital, Catanzaro, Italy. Pacifici, National Centre on Addiction and Doping, Istituto Superiore di Sanita, V.le Regina Elena 299, Rome. Italy. Sanguigni, Department of Neurology, Madonna del Soccorso Hospital, S Benedetto del Tronto, Italy.

Alteplase is the main pharmacological treatment available for intravenous thrombolysis in patients with acute ischemic stroke. Endovascular treatment alone or add-on to intravenous thrombolysis is a valid approach in acute ischemic stroke with cerebral large vessel disease. The most common serious adverse reaction related to alteplase is the development of spontaneous intracerebral hemorrhage and the presence of cerebral small vessel disease may increase this risk, particularly in cocaine users, even if only few data have been published on this topic. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386426PMC
February 2019
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Low-Intensity Focused Ultrasound-Responsive Phase-Transitional Nanoparticles for Thrombolysis without Vascular Damage: A Synergistic Nonpharmaceutical Strategy.

ACS Nano 2019 Mar 14;13(3):3387-3403. Epub 2019 Mar 14.

Department of Radiology , Second Affiliated Hospital of Chongqing Medical University , No. 74 Linjiang Road , Yuzhong District, Chongqing , 400010 , People's Republic of China.

Multimodal molecular imaging has shown promise as a complementary approach to thrombus detection. However, the simultaneous noninvasive detection and lysis of thrombi for cardiovascular diseases remain challenging. Herein, a perfluorohexane (PFH)-based biocompatible nanostructure was fabricated, namely, as-prepared FeO-poly(lactic- co-glycolic acid)-PFH-CREKA nanoparticles (NPs), which combine phase transition (PT) thrombolysis capabilities with properties conducive to multimodal imaging. Read More

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http://dx.doi.org/10.1021/acsnano.8b09277DOI Listing
March 2019
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Low-dose i.v. urokinase for coronary thrombosis in Kawasaki disease.

Pediatr Int 2019 Mar 10;61(3):302-303. Epub 2019 Mar 10.

Department of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

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http://dx.doi.org/10.1111/ped.13783DOI Listing
March 2019
2 Reads

Management of Blood Pressure During and After Recanalization Therapy for Acute Ischemic Stroke.

Front Neurol 2019 21;10:138. Epub 2019 Feb 21.

Department of Neurology, University of California, San Francisco, San Francisco, CA, United States.

Ischemic stroke is a common neurologic condition and can lead to significant long term disability and death. Observational studies have demonstrated worse outcomes in patients presenting with the extremes of blood pressure as well as with hemodynamic variability. Despite these associations, optimal hemodynamic management in the immediate period of ischemic stroke remains an unresolved issue, particularly in the modern era of revascularization therapies. Read More

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http://dx.doi.org/10.3389/fneur.2019.00138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394277PMC
February 2019
2 Reads

Use of Emergency Medical Services and Timely Treatment Among Ischemic Stroke.

Stroke 2019 Apr;50(4):1013-1016

From the China National Clinical Research Center for Neurological Diseases (H.-Q.G., X.Y., C.-J.W., Y.-L.W., C.-Y.W., H.L., Z.-X.L., Y.-J.W.), Beijing Tiantan Hospital, Capital Medical University, China.

Background and Purpose- Emergency medical services (EMSs) are critical for early treatment of patients with ischemic stroke, yet data on EMS utilization and its association with timely treatment in China are still limited. Methods- We examined data from the Chinese Stroke Center Alliance for patients with ischemic stroke from June 2015 to June 2018. Absolute standardized difference was used for covariates' balance assessments. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.024232DOI Listing
April 2019
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New Directions in the Management of Peripheral Artery Disease.

Am J Ther 2019 Mar/Apr;26(2):e284-e293

General Medicine Faculty, Cardio-Thoracic Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Background: Peripheral artery disease represents an important chapter of cardiovascular pathology in which atherosclerosis (promoted by major risk factors-hypertension, smoking, dyslipidemia, and diabetes mellitus) is the major etiology. The severity of this pathology is not only due to local injury but also due to frequent association with atherosclerotic disease with other localizations, thus increasing cardiovascular morbidity and mortality in these patients. Diagnosis is based on clinical data, functional tests (the ankle-brachial index is very useful in these cases) and imagistic methods (Doppler ultrasonography, computed tomography angiography, magnetic resonance angiography, and digital subtraction angiography). Read More

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http://dx.doi.org/10.1097/MJT.0000000000000916DOI Listing
March 2019
2 Reads

Therapeutic Advances in Emergency Cardiology: Acute Pulmonary Embolism.

Am J Ther 2019 Mar/Apr;26(2):e248-e256

County Emergency Hospital, Baia Mare, Romania.

Background: Acute pulmonary embolism (PE) requires rapid diagnosis and early and appropriate treatment, often under conditions of hemodynamic instability. The therapeutic strategy should optimally integrate the therapeutic arsenal in a multidisciplinary but unitary approach.

Areas Of Uncertainty: The short list of the major uncertainties associated with acute PE should include limited general public awareness on venous thromboembolism, acute hemodynamic support not based on evidence from randomized clinical trials, with few updates lately, mainly linked to extracorporeal membrane oxygenation, thrombolytic therapy having firm indications only in high-risk PE, without clear strategies for particular clinical situations (ie, stroke, tumors, thrombi in transit, and cardiac arrest), using old therapeutic agents with old administration regimens, lack of evidence from large-volume trials on the optimal interventional approach, and relatively imprecise indications for surgical treatment. Read More

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http://Insights.ovid.com/crossref?an=00045391-201904000-0000
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http://dx.doi.org/10.1097/MJT.0000000000000917DOI Listing
March 2019
11 Reads
1.127 Impact Factor

Current Perspectives in Facilitated Angioplasty.

Am J Ther 2019 Mar/Apr;26(2):e208-e212

Cardiology Department, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania.

Background: Ischemic heart disease represents the most important cause of mortality worldwide, and the management of patients with ST-elevation myocardial infarction (STEMI) still remains a great challenge. For a great number of patients who do not have immediate access to primary percutaneous coronary intervention (PCI), facilitated angioplasty may be a reasonable therapeutic option.

Areas Of Uncertainty: The goal of reperfusion therapy is achieving repermeabilization of the infarct-related artery. Read More

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http://dx.doi.org/10.1097/MJT.0000000000000914DOI Listing
March 2019
6 Reads
1.127 Impact Factor

Ultrasound-accelerated catheter-assisted thrombolytic therapy applicatıons in deep vein thrombosis.

Niger J Clin Pract 2019 Mar;22(3):399-405

Department of Radiology, Faculty of Medicine, Gazi University, Ankara, Turkey.

Background: Ultrasound-accelerated catheter-directed thrombolysis (UCT) increases the invasion of thrombolytic agent into the thrombus using ultrasonic energy, provides less infusion of thrombolytic agent, reduces complication, and post-thrombotic syndrome (PTS) development rates. For these reasons, this procedure is a promising method for the treatment of deep vein thrombosis (DVT).

Materials And Methods: Patients diagnosed with DVT by ultrasonography (USG) who underwent UCT between May 2013 and August 2014 at Gazi University Hospital Cardiovascular Surgery Clinic were included in the study. Read More

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http://dx.doi.org/10.4103/njcp.njcp_27_18DOI Listing
March 2019
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Applications of Liposomal Drug Delivery Systems to Develop Neuroprotective Agents for the Treatment of Ischemic Stroke.

Biol Pharm Bull 2019 ;42(3):319-326

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka.

Ischemic stroke is one of the leading causes of severe disability and death. In clinical settings, tissue plasminogen activator (t-PA) for thrombolytic therapy is the only globally approved drug for the treatment of ischemic stroke. However, the proportion of patients who receive t-PA therapy is extremely limited due to its narrow therapeutic time window (TTW) and the risk of cerebral hemorrhage. Read More

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http://dx.doi.org/10.1248/bpb.b18-00683DOI Listing
January 2019
1 Read