Search Our Scientific Publications & Authors

Zhonghua Yi Xue Za Zhi 2019 Mar;99(10):739-743

Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing100029, China.

To investigate the effect of obstructive sleep apnea (OSA) on the severity of acute pulmonary thromboembolism (PTE). Clinical data of patients with acute PTE and OSA who were admitted to Anzhen Hospital from January 2015 to December 2017 were retrospectively analyzed in this study.According to the apnea hypopnea index (AHI), patients were divided into AHI≤15/h group and AHI>15/h group. Read More

Eur J Clin Invest 2019 Mar 18:e13103. Epub 2019 Mar 18.

Department of Cardiology, Aarhus University Hospital, Denmark.

Background: Only few studies in selected cohorts have examined whether the CHA DS -VASc score can predict the risk of atrial fibrillation and thromboembolic events in patients without atrial fibrillation.

Materials And Methods: Patients with coronary angiography performed between 2004-2012 were grouped according to CHA DS -VASc score. We excluded patients with atrial fibrillation, anticoagulant therapy, and follow-up <30 days. Read More

Br J Haematol 2019 Mar 18. Epub 2019 Mar 18.

Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA.

PLoS One 2019 18;14(3):e0213517. Epub 2019 Mar 18.

The Cardiovascular Department, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.

Background: Previous studies indicated low-intensity warfarin (INR target of 1.5-2.5) achieved reduced hemorrhage without increasing thromboembolism for Asians with non-valvular atrial fibrillation (NVAF). Read More

ASAIO J 2019 Mar 13. Epub 2019 Mar 13.

From the Department of Neurology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

Although heart transplantation remains the gold standard for management of heart failure, ventricular assist devices (VAD) have emerged as viable alternatives. VAD implantation improves kidney function. However, whether the improvement is sustained or associated with improved outcomes is unclear. Read More

J Trauma Acute Care Surg 2019 Mar 13. Epub 2019 Mar 13.

Division of Pediatric General Surgery, UCSF Benioff Children's Hospital Oakland, Oakland, CA.

Background: Early tracheostomy has been associated with shorter hospital stay and fewer complications in adult trauma patients. Guidelines for tracheostomy have not been established for children with severe TBI. The purpose of this study was to 1) define nationwide trends in time to extubation and time to tracheostomy; and 2) determine if early tracheostomy is associated with decreased length of stay and fewer complications in children with severe TBI. Read More

J Med Internet Res 2019 Mar 18;21(3):e10810. Epub 2019 Mar 18.

eHealth Unit, Research Department of Primary Care and Population Health, University College London, London, United Kingdom.

Background: Searching for health information online is increasingly common and is an obvious source of information about oral combined hormonal contraceptives (CHCs) and their risks. However, little is known about how publicly available websites address the risks of CHCs, particularly venous thromboembolism (VTE).

Objective: The aim was to explore the information available to women about VTE and other risks of CHCs on websites available through commonly used search engines. Read More

Intractable Rare Dis Res 2019 Feb;8(1):60-66

Venous Thromboembolism Unit, Department of Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Behçet's Disease (BD) is a rare, chronic and recurrent inflammatory multisystemic condition of unknown origin that can affect any tissue. The vascular system is involved in 5-40% of cases of BD, including venous and arterial beds and it has a relapsing course. Budd-Chiari syndrome (BCS) is a rare complication of BD with a frequency of < 5% among patients with vascular involvement and is more frequent in men (89. Read More

Eur J Prev Cardiol 2019 Mar 16:2047487319836572. Epub 2019 Mar 16.

1 Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia.

Background: The role of extended thromboprophylaxis is established for surgical patients, but not yet for hospitalised medical patients.

Design: This systematic review and meta-analysis sought to explore the role of extended thromboprophylaxis for medically ill hospitalised patients.

Methods: Medline, EMBASE and Cochrane Libraries were searched and five randomised controlled trials were identified, comprising 20,046 extended and 20,078 standard duration thromboprophylaxis patients. Read More

Neurol Sci 2019 Mar 18. Epub 2019 Mar 18.

Women's Headache Center, Department of Surgical Sciences, University of Turin, Via Ventimiglia 3, 10126, Turin, Italy.

Pregnancy can be seen as a positive time for women migraineurs because the elevated estrogen and endogenous opioid levels raise the pain threshold and the stable hormone levels, which no longer fluctuate, eliminate a major trigger factor for the attacks. In a great majority of cases, indeed, migraine symptoms spontaneously improve throughout pregnancy. Generally, migraine without aura (MO) improves better than migraine with aura (MA), which can occur ex novo in pregnancy more frequently than MO. Read More

Nephrol Dial Transplant 2019 Mar 16. Epub 2019 Mar 16.

the Academy of Romanian Scientists (AOSR).

Dialysis patients manifest both an increased thrombotic risk and a haemorrhagic tendency. A great number of patients with chronic kidney disease requiring dialysis have cardiovascular comorbidities (coronary artery disease, atrial fibrillation or venous thromboembolism) and different indications for treatment with antithrombotics (primary or secondary prevention). Unfortunately, few randomized controlled trials deal with antiplatelet and/or anticoagulant therapy in dialysis. Read More

BMJ Open 2019 Mar 15;9(3):e024159. Epub 2019 Mar 15.

Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada.

Objective: To compare and contrast illustrative examples of the adoption of high value practices and the de-adoption of low value practices.

Design: (1) Retrospective, population-based audit of low molecular weight heparin (LMWH) for venous thromboembolism (VTE) prophylaxis (high value practice) and albumin for fluid resuscitation (low value practice) and (2) cross-sectional survey of healthcare providers.

Setting: Data were collected from nine adult medical-surgical intensive care units (ICUs) in two large Canadian cities. Read More

Inflamm Bowel Dis 2019 Mar 16. Epub 2019 Mar 16.

Section of Gastroenterology, Boston Medical Center, Boston, Massachusetts.

The peak incidence of the inflammatory bowel diseases (IBDs) is between the second and fourth decades of life, which coincides with prime reproductive years. Unplanned or mistimed pregnancies may account for nearly half of all pregnancies and are associated with adverse consequences such as a higher risk of delayed preconceptual care, increased risk of preterm birth, low birth weight, and adverse maternal and neonatal outcomes. Increased IBD activity during pregnancy is also associated with adverse pregnancy-related outcomes, such as miscarriage, intrauterine growth retardation, and preterm birth. Read More

J Thromb Thrombolysis 2019 Mar 15. Epub 2019 Mar 15.

National Institutes of Health, 10 Center Drive, Room 4W-3740, Bethesda, MD, 20892, USA.

Patients with hepatopancreatobiliary (HPB) malignancies undergoing resection are prone to venous thromboembolism (VTE), and current guidelines recommend up to 28 days of chemoprophylaxis after major surgery. We sought to determine the practice patterns among HPB surgeons for use of chemoprophylaxis after discharge. A survey on VTE chemoprophylaxis after oncologic HPB operations was distributed to attending surgeons at the 18 HPB fellowship training programs in the United States and Canada. Read More

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Mar 12. Epub 2019 Mar 12.

Department of Medical Oncology, AC Camargo Cancer Center, São Paulo, SP, Brazil.

Introduction: Gastric cancer (GC) is among the leading neoplasms with highest morbidity and mortality in the world. Tumor angiogenesis represents one of important targets of antineoplastic treatment, as it has an important role in cell development and growth.

Case Report: Ramucirumab, an IgG1 monoclonal antibody (MoAb), inhibits the angiogenesis pathway by blocking the VEGFR-2 activation. Read More

Semergen 2019 Mar 12. Epub 2019 Mar 12.

Enfermería, EAP Raval Nord, Atención Primaria, Institut Català de la Salut, Barcelona, España.

In Spain, approximately 25% of patients anticoagulated due to non-valvular atrial fibrillation use a direct-acting anticoagulant (DOAC). It is foreseeable that most of them at some point in their lives should undergo invasive procedures or surgical treatments. This makes the management of DOAC in these situations essential in order to perform the procedure with maximum safety and minimise the risk to the maximum of haemorrhage and thrombosis. Read More

Thromb Res 2019 Mar 6;177:117-121. Epub 2019 Mar 6.

The Ottawa Hospital Research Institute, 725 Parkdale Ave, Ottawa, Ontario K1Y 4E9, Canada; The Ottawa Hospital, Box 710, 501 Smyth Rd., Ottawa, Ontario K1H 8L6, Canada. Electronic address:

Background: Implanted vascular access devices (IVADs) have significantly improved the management of cancer patients. These patients are at an increased risk of venous thromboembolism and IVADs are a known risk factor. We sought to assess the incidence of IVAD-related upper extremity deep vein thrombosis (IVAD-related UEDVT) associated with BioFlo® IVADs (Angiodynamics, Inc. Read More

Turk Kardiyol Dern Ars 2019 Mar;47(2):111-121

Department of Cardiology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.

Objective: The aim of this study was to determine the relationship of left atrial appendage (LAA) mechanics assessed using 2-dimensional (2D)-strain analysis of the gray scale images obtained during transesophageal echocardiography (TEE) to the conventional LAA functional parameters, CHA2DS2-VASc score, and the presence of spontaneous echo contrast (SEC) and/or LAA thrombus in patients with non-valvular atrial fibrillation (AF).

Methods: The study included 126 patients with AF and 30 controls with a sinus rhythm who were referred for TEE. The global, medial, lateral and apical LAA longitudinal 2D-strain of all patients and the CHA2DS2-VASc score of AF patients were evaluated. Read More

J Am Heart Assoc 2019 Mar;8(6):e011407

1 Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark.

Background Childhood weight trajectories may influence cardiometabolic traits and thereby the risk of venous thromboembolism ( VTE ) later in life. We examined whether overweight and changes in weight status during childhood were associated with risk of VTE in adulthood. Methods and Results We used Danish medical registries to conduct a population-based cohort study of Danish schoolchildren aged 7 to 13 years and born during 1930-1989. Read More

Front Oncol 2019 26;9:45. Epub 2019 Feb 26.

Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School Boston, MA, United States.

Immunomodulatory drugs (IMiDs), including thalidomide, lenalidomide, and pomalidomide, have improved survival of patients with multiple myeloma (MM). However, these therapies are associated with an increased risk of venous thromboembolism (VTE). Apixaban has been approved for treatment of acute VTE and for risk reduction of recurrent VTE following initial therapy. Read More

Haematologica 2019 Mar 14. Epub 2019 Mar 14.

Preventive Cardiology and Preventive Medicine, University Medical Center Mainz.

Gynecol Oncol 2019 Mar 11. Epub 2019 Mar 11.

Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Objective: To evaluate the efficacy and economic impact of a transfusion reduction initiative for patients undergoing gynecologic surgery.

Methods: We conducted a prospective healthcare improvement study to align transfusion practices with the American Society of Hematology's Choosing Wisely® campaign. Baseline transfusion rates were determined retrospectively for all major gynecologic surgical cases from 3/1/14 to 6/30/14. Read More

Eur J Intern Med 2019 Mar 11. Epub 2019 Mar 11.

Department of Internal Medicine, Hospital Universitario Germans Trias i Pujol de Badalona. Barcelona, Universidad Autónoma de Barcelona, Spain.

Background: Little is known on the clinical characteristics, risk factors and outcomes during anticoagulation in young patients with acute venous thromboembolism (VTE).

Methods: We used data from the RIETE (Registro Informatizado Enfermedad TromboEmbólica) registry to assess the clinical characteristics, risk factors and outcomes during anticoagulation in VTE patients aged 10-24 years. Data were separately analyzed according to initial presentation and gender. Read More

Am J Med 2019 Mar 11. Epub 2019 Mar 11.

Edinburgh Heart Centre, Royal Infirmary of Edinburgh, Edinburgh, UK.

Background: Left ventricular thrombus formation is a complication of acute myocardial infarction.. However, the incidence and risk of systemic thromboembolism in the era of primary angioplasty for ST elevation myocardial infarction (STEMI) is unclear. Read More

J Cardiol 2019 Mar 11. Epub 2019 Mar 11.

Medicine Division, Nippon Boehringer Ingelheim Co., Ltd., Tokyo, Japan.

Background: The effectiveness and safety of dabigatran etexilate (DE) have not been elucidated thoroughly in clinical practice for Japanese patients with non-valvular atrial fibrillation (NVAF). In particular, those of DE at a reduced dose due to dose reduction recommendations (DRR) remain unknown.

Methods: NVAF patients who had newly initiated DE treatment for prevention of thromboembolic events between December 2011 and November 2013 were enrolled. Read More

J Am Coll Cardiol 2019 Mar;73(10):1123-1131

Division of Cardiology, Department of Internal Medicine, St. Paul's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Background: Patients with mitral stenosis and atrial fibrillation (AF) require anticoagulation for stroke prevention. Thus far, all studies on direct oral anticoagulants (DOACs) have excluded patients with moderate to severe mitral stenosis.

Objectives: The aim of this study was to validate the efficacy of DOACs in patients with mitral stenosis. Read More

Ann Plast Surg 2019 Mar 12. Epub 2019 Mar 12.

From the Division of Plastic and Reconstructive Surgery, Keck School of Medicine of USC, Los Angeles, CA.

Background: Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, represents a significant perioperative complication. However, the outcomes of lower extremity salvage in the setting of perioperative VTE are not well reported.

Methods: A retrospective review of lower extremity trauma patients requiring soft tissue reconstruction between July 2007 and December 2015 at an urban trauma center was performed. Read More

IEEE Trans Ultrason Ferroelectr Freq Control 2019 Mar 8. Epub 2019 Mar 8.

Left atrial appendage (LAA) occlusion is used to reduce the risk of thromboembolism in patients with nonvalvular atrial fibrillation, by obstructing the LAA through a percutaneously delivered device. Nonetheless, correct device sizing is complex, requiring the manual estimation of different measurements in pre-/peri-procedural images, which is tedious, time-consuming and with high inter- and intra-observer variability. In this work, a semi-automatic solution to estimate the required relevant clinical measurements is described. Read More

Rev Prat 2018 Apr;68(4):394-400

Maternité et gynécologie, hôpital universitaire mère-enfant Robert-Debré, AP-HP, Paris, France.

Hormonal contraception and vascular risk. Since the early 1960, it has been well documented that combined hormonal contraceptives (CHC) increase the risk of venous thromboembolism diseases (VTE) and arterial diseases, even if it is an uncommon disease before menopause. Vascular risk is the most important determinant of the benefit/ risk profile of hormonal contraceptive. Read More

Hamostaseologie 2019 Mar 13. Epub 2019 Mar 13.

Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.

Immune thrombocytopenia (ITP) occurs with an incidence rate of 1.6 to 3.9 per 100,000 patient-years, which increases with age and has a slight female preponderance. Read More

Curr Opin Oncol 2019 Mar 8. Epub 2019 Mar 8.

Department of Diabetes, Endocrinology & Metabolism, Royal North Shore Hospital, St Leonards.

Purpose Of Review: Tyrosine kinase inhibitors (TKI), predominantly vandetanib and cabozantinib, are increasingly used for management of advanced medullary thyroid cancer. This review aims to discuss the major and serious adverse events associated with TKI.

Recent Findings: The choice of TKI depends on the patient's existing comorbidities. Read More

Cardiovasc Intervent Radiol 2019 Mar 12. Epub 2019 Mar 12.

Department of Internal Medicine, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands.

Purpose: To provide insight into the current use and results of ultrasound-facilitated catheter-directed thrombolysis (USAT) in patients with high-risk pulmonary embolism (PE).

Introduction: Systemic thrombolysis is an effective treatment for hemodynamically unstable, high-risk PE, but is associated with bleeding complications. USAT is thought to reduce bleeding and is therefore advocated in patients with high-risk PE and contraindications for systemic thrombolysis. Read More

Int Urogynecol J 2019 Mar 12. Epub 2019 Mar 12.

The Ohio State University Wexner Medical Center, Female Pelvic Medicine and Reconstructive Surgery, 395 W 12th Ave, 5th Floor, Columbus, OH, 43210, USA.

Introduction And Hypothesis: The primary aim was to compare the incidence of major perioperative complications in women undergoing vaginal reconstructive surgery with general, regional, and monitored anesthesia care using a national database. The secondary aim was to compare length of hospital stay, 30-day readmission rates, urinary tract infections, and reoperation rates between anesthesia types.

Materials And Methods: The National Surgical Quality Improvement Program database was used to study women undergoing vaginal surgery for pelvic floor disorders from 2006 to 2015 via Current Procedural Terminology codes. Read More

Autops Case Rep 2019 Jan-Mar;9(1):e2018061. Epub 2019 Jan 14.

Università degli Studi di Milano, Dipartimento di Scienze Biomediche per la Salute, Sezione di Medicina Legale e delle Assicurazioni. Milano, Italy.

Pulmonary thromboembolism (PTE) is one of the major complications in oncologic patients. The incidence of PTE in these cases is 4 to 7 times higher than in non-oncologic patients. Ovarian tumors, specifically those of large sizes, may impair the blood flow through the pelvic veins as tumor pressure over the pelvic vessels increases the incidence of thrombosis. Read More

Cardiovasc Revasc Med 2019 Mar 5. Epub 2019 Mar 5.

Department of Medicine, University of Florida, 1600 SW Archer Road, PO Box 100277, Gainesville, FL, 32610, United States of America.

Background: Anti-thrombotic regimen in patients on long term anticoagulation requiring coronary intervention remains a clinical challenge.

Methods: We performed a meta-analysis of observational studies and randomized controlled trials comparing outcomes of triple therapy (dual antiplatelet therapy and anticoagulant) with dual therapy (P2Y12 inhibitor and anticoagulant) in patients on long-term anticoagulants after percutaneous coronary intervention (PCI). Major bleeding was the primary outcome. Read More

J Biomater Appl 2019 Mar 16;33(8):1060-1069. Epub 2019 Jan 16.

2 Shanghai MicroPort Medical (Group) Co., Ltd, Shanghai, China.

Inferior vena cava filter has been increasingly applied in clinical practice to prevent pulmonary embolism. Nowadays, various complications after implanting conventional filters seriously hinder clinical applications. Therefore, in this paper, a novel biodegradable inferior vena cava filter was designed based on biodegradable materials, which is an hourglass-like filter anchored inside a stent structure fixed by connecting fibers. Read More

JAMA 2019 03;321(10):1007

Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

JAMA 2019 03;321(10):1006

Department of Radiology, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire.

Am J Hematol 2019 Mar 11. Epub 2019 Mar 11.

Department of Vascular Medicine, and CNRS / TIMC-IMAG UMR 5525 / Themas and F-CRIN InnoVTE network, Grenoble, France.

The risk of venous thromboembolism (VTE) is higher in myeloma patients receiving immunomodulatory compounds. A VTE prophylaxis using low-molecular-weight heparin or aspirin is therefore proposed. Apixaban is an oral direct anti-Xa. Read More

J Thromb Thrombolysis 2019 Mar 11. Epub 2019 Mar 11.

Pfizer Inc, New York, NY, USA.

In patients with active cancer and acute venous thromboembolism (VTE), the low-molecular-weight-heparin (LMWH) dalteparin is more effective than vitamin K antagonist (VKA) in reducing the risk of recurrent venous thromboembolism (rVTE) without increasing the risk of bleeding. However, the relative benefit of LMWH versus VKA in patients with active cancer at high or low risk of rVTE and bleeding is unclear. This post hoc analysis used data from the CLOT study to explore the efficacy and safety of LMWH versus VKA in preventing recurrent thrombosis in high- and low-risk patients with active cancer. Read More

Respir Med Case Rep 2019 22;26:296-298. Epub 2019 Feb 22.

Berkshire Medical Center, Pittsfield, MA 01201, USA.

Pulmonary veins (PVs) are the most proximal source of arterial thromboembolism. Pulmonary vein thrombosis (PVT) is an uncommon clinical condition that can be fatal. Its incidence or prevalence is unclear as existing cases are case reports. Read More

Plast Reconstr Surg Glob Open 2019 Jan 4;7(1):e1855. Epub 2019 Jan 4.

Department of Plastic and Reconstructive Surgery, Johns Hopkins Hospital, Baltimore, Md.

Enhanced recovery after surgery pathways are well established in other surgical specialties but are relatively new in plastic surgery. These guidelines focus on improving patient care by incorporating evidence-based recommendations. Length of stay is shorter, and overall hospital costs are lower without compromising patient satisfaction. Read More

J Vasc Interv Radiol 2019 Mar 8. Epub 2019 Mar 8.

Non-invasive Cardiovascular Laboratory, Frederik Meijer Heart and Vascular Institute, Spectrum Health Hospitals, 100 Michigan St NE, Grand Rapids, MI 49503.

Purpose: To evaluate the clinical effectiveness of ultrasound-assisted thrombolysis (USAT) in resolution of right ventricular dysfunction (RVD), preservation of cardiopulmonary function, and quality of life (QoL) in patients with acute submassive pulmonary embolism (PE).

Materials And Methods: A single-center prospective study of patients presenting with acute PE and signs of RVD, as determined by right ventricle-to-left ventricle diameter ratio (RV:LV) > 0.9 on computed tomographic angiography of the thorax, was performed. Read More

Int J Cardiol 2019 Feb 27. Epub 2019 Feb 27.

Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China. Electronic address:

Background: Cryoballoon (CB) versus radiofrequency (RF) ablation response on prothrombotic biomarkers obtained different results at short-term, while long-term is still unknown in atrial fibrillation (AF) treatment. We evaluated short and long-term changes in platelet and inflammatory biomarkers after CB and RF ablation.

Methods: Fifty-eight paroxysmal AF patients were randomized for pulmonary vein (PV) isolation using either CB (n = 29) or RF (n = 29) ablation. Read More

Otolaryngol Head Neck Surg 2019 Mar 12:194599819835743. Epub 2019 Mar 12.

1 Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, California, USA.

Objective: To determine the incidence of postoperative venous thromboembolism (VTE) in adults undergoing otologic surgery.

Study Design: Cross-sectional retrospective study.

Setting: Single tertiary academic center. Read More

Asian Cardiovasc Thorac Ann 2019 Mar 11:218492319836910. Epub 2019 Mar 11.

1 Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Pulmonary artery angiosarcoma is a rare malignant vascular tumor with an aggressive clinical course and a poor prognosis. Hemoptysis and shortness of breath have been reported as common clinical presentations. The exact clinicopathology is unknown. Read More

J Clin Med 2019 Mar 9;8(3). Epub 2019 Mar 9.

Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, No. 1, Section 1, Jen-Ai Road, Taipei 100, Taiwan.

Atrial fibrillation (AF) is a common cardiac arrhythmia and is one of the major causes of ischemic stroke. In addition to the clinical factors such as CHADS2 or CHADS2-VASC score, the impact of genetic factors on the risk of thromboembolic stroke in patients with AF has been largely unknown. Single-nucleotide polymorphisms in several genomic regions have been found to be associated with AF. Read More

J Clin Med 2019 Mar 8;8(3). Epub 2019 Mar 8.

Department of Medicine, University of Verona, Pz.le Scuro 10, 37134 Verona, Italy.

Direct oral anti-coagulants (DOACs) are employed in clinical practice for the prevention and treatment of recurrent venous thromboembolism and for the prevention of stroke in non-valvular atrial fibrillation. DOACs directly and reversibly inhibit activated factor X or thrombin and can interfere with other pathophysiological processes such as inflammation, lipid metabolism, and bone turnover. We aimed to evaluate the possible effects of DOACs on osteogenesis and angiogenesis. Read More