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Int J Colorectal Dis 2020 May 1. Epub 2020 May 1.

Nottingham Colorectal Service, Nottingham University Hospitals NHS Trust, E Floor West Block, QMC Campus, Nottingham, NG7 2UH, UK.

Purpose: Primary care studies suggest that thrombocytosis (platelet counts > 400 × 10/L) is associated with an increased risk of colorectal cancer (CRC). We aimed to establish whether this marker has significant stratification value in patients seen in secondary care.

Methods: A retrospective review of 2991 patients referred to our colorectal 2-week-wait (2WW) pathway between August 2014 and August 2017. Read More

Arch Gynecol Obstet 2020 May 10;301(5):1267-1274. Epub 2020 Apr 10.

Department of Gynecology and Obstetrics, University Hospital Giessen and Marburg, Marburg, Germany.

Purpose: Although thrombocytosis in patients with primary ovarian cancer has been widely investigated, there are only very few data about the role of thrombocytosis in recurrent ovarian cancer. The aim of our study was to investigate the impact of pretreatment thrombocytosis prior to chemotherapy on clinical outcome in patients with recurrent platinum eligible ovarian cancer.

Methods: In our retrospective analysis we included 300 patients who were treated by AGO Study Group Centers within three prospective, randomized phase-III-trials. Read More

Front Med (Lausanne) 2020 28;7:66. Epub 2020 Feb 28.

Pediatric Unit, Department of Biomedical Science and Human Oncology, University of Bari "Aldo Moro", Bari, Italy.

The thrombopoietin receptor agonist eltrombopag has been shown to be safe and effective for children with chronic immune thrombocytopenia (ITP). The aim of the present study was to characterize eltrombopag use in current clinical practice. This is a retrospective multicenter study conducted in 17 centers affiliated to the Italian Association of Pediatric Hematology and Oncology (AIEOP). Read More

Platelets 2020 Feb 27:1-6. Epub 2020 Feb 27.

Australian Centre for Blood Diseases, Monash University, Melbourne, Australia.

The spleen, in addition to its role in immunity, plays key roles in erythrocyte maintenance and platelet sequestration. Loss of the spleen via splenectomy occurs in approximately 6.4 to 7. Read More

Turk J Pediatr 2019 ;61(5):664-670

Divisions of Hematology, Department of Pediatrics, Ondokuz Mayıs University School of Medicine, Samsun, Turkey.

Karakurt N, Uslu İ, Aygün C, Albayrak C. Hematological disturbances in Down syndrome: single centre experience of thirteen years and review of the literature. Turk J Pediatr 2019; 61: 664-670. Read More

Ann Hematol 2020 Apr 7;99(4):897-898. Epub 2020 Feb 7.

Hematology and transplantation unit, Saint Louis Hospital, APHP, 1 avenue Claude Vellefaux, 75010, Paris, France.

Cytogenet Genome Res 2020 1;160(1):18-21. Epub 2020 Feb 1.

Multiple isodicentric Y chromosomes [idic(Y)] is a rare cytogenetic abnormality, most exclusively described in constitutional karyotypes. Only recently has this entity been reported in hematologic neoplasms such as myeloid disorders, albeit these cases remain very scarce. The possible involvement of increasing copies of potential proto-oncogenes located on the multiple idic(Y) led to consider one of them, CRLF2, as a target for kinase inhibitors. Read More

BMJ Case Rep 2020 Jan 8;13(1). Epub 2020 Jan 8.

Department of Haematology, Vejle Hospital, Vejle, Denmark

Iron deficiency is a common cause of reactive thrombocytosis resulting in usually mild to moderately increased but sometimes even in extreme thrombocytosis (ie, >1000×10/L). We report a case of a 34-year-old woman who developed an increased platelet count of 1953×10/L. Upon admission, cytoreductive therapy was initiated until an underlying chronic myeloproliferative neoplasia was ruled out. Read More

Sci Rep 2019 12 27;9(1):19838. Epub 2019 Dec 27.

Department of Haematology, University Medical Centre Ljubljana, Zaloska 7, 1000, Ljubljana, Slovenia.

Suspicion of myeloproliferative neoplasms (MPNs) and especially essential thrombocythemia (ET) in primary care is often based solely on blood counts, with patients referred to a haematologist without a thorough evaluation. We retrospectively assessed the role of calreticulin gene (CALR) mutations in the diagnosis of MPN in this population. We studied CALR mutations in 524 JAK2 V617F-negative patients with suspected MPN. Read More

Hematology Am Soc Hematol Educ Program 2019 12;2019(1):391-396

Centre for Medical Education, Queen's University Belfast, Belfast, United Kingdom.

In the patient presenting with an elevated blood count who does not have an acquired clonal disorder causing a myeloproliferative neoplasm, hereditary erythrocytosis or hereditary thrombocytosis needs to be considered as a possible explanation. A young patient and/or those with a family history of myeloproliferative neoplasm should specifically raise this possibility. Among the causes of hereditary erythrocytosis are mutations in the genes in the oxygen sensing pathway and high-affinity hemoglobins. Read More

J Thromb Thrombolysis 2020 Jan;49(1):141-144

Division of Neurology, Department of Medicine, National University Health System, Singapore, Singapore.

Adult Onset Still's Disease (AOSD) is a systemic inflammatory disease of unknown aetiology. The usual manifestations of AOSD are spiking fevers, arthritis, and an evanescent salmon-pink rash, with neurological manifestations occasionally described. Stroke is a rare manifestation of AOSD and the exact mechanism for stroke in AOSD remains unknown, although it has been hypothesized to be secondary to thrombocytosis or vasculitis. Read More

Anticancer Res 2019 Nov;39(11):6273-6282

Cancer Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.

Background/aim: We have yet to understand why JAK2-positive myeloproliferative neoplasms (MPN) patients manifest different phenotypes despite harboring JAK2 mutations and what drives secondary transformations.

Patients And Methods: Using targeted sequencing, we analyzed mutational status of 17 polycythemia vera (PV), 16 essential thrombocythemia (ET), 8 primary myelofibrosis (PMF) patients who tested positive for JAK by polymerase chain reaction.

Results: The somatic mutations in JAK2 influence the clinical behavior of the disease. Read More

FP Essent 2019 Oct;485:32-43

Department of Family Medicine at Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra Blvd, Hempstead, NY 11549.

Platelets have an important role in hemostasis. Platelet disorders occur when too few or too many platelets are present, or when platelet functions are abnormal. Thrombocytopenia, defined as a platelet count less than 150,000/mcL, can be acute or chronic and congenital or acquired. Read More

Am J Hematol 2020 01 1;95(1):E1-E3. Epub 2019 Nov 1.

Hematology, Ospedale di Circolo, ASST Sette Laghi, Varese, Italy.

Eur J Haematol 2020 Jan 22;104(1):46-54. Epub 2019 Nov 22.

Department of Hematology, Zealand University Hospital, Roskilde, Denmark.

Background: Iron deficiency in polycythaemia vera (PV) may impact the validity of the haematocrit (HCT), since HCT is red blood cell count (RBC) × mean corpuscular volume (MCV).

Objectives: To investigate (a) the effect of microcytosis on HCT, (b) the erythrocyte sedimentation rate (ESR) as a possible additional diagnostic marker for PV.

Material And Methods: This study included 182 subjects: 39 with PV, 27 with essential thrombocythemia (ET) and 116 suspected of myeloproliferative neoplasm (MPN) with a secondary cause for either thrombocytosis or erythrocytosis. Read More

Am J Hematol 2019 12 10;94(12):E314-E317. Epub 2019 Sep 10.

Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

Case Rep Neurol Med 2019 18;2019:8647126. Epub 2019 Jul 18.

Department of Neurology, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Thrombocytosis, hypercoagulable state, and hypoxia secondary to anemia are some of the mechanisms that are thought to cause strokes in patients with iron deficiency anemia (IDA). Several cases of middle-aged females with IDA who had embolic strokes due to aortic arch thrombosis have been reported. Majority of the cases were treated with anticoagulation. Read More

J Pediatr Gastroenterol Nutr 2019 11;69(5):e129-e134

Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition.

Objectives: Children with Crohn's disease may present with malnutrition and linear growth impairment, which can be secondary to insufficient caloric intake, chronic inflammation, malabsorption, and suppression of growth-promoting hormones. We evaluated clinical, serologic, and genetic data to determine risk factors for impaired anthropometrics in Crohn's disease at diagnosis.

Methods: Our study evaluated 772 children newly diagnosed with Crohn's disease, inflammatory phenotype, enrolled in the RISK Stratification Project to determine the factors associated with anthropometric impairment. Read More

Ther Adv Musculoskelet Dis 2019 18;11:1759720X19864822. Epub 2019 Jul 18.

Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama, Japan.

Background: This study aimed to identify the clinical subgroups of polymyalgia rheumatica (PMR) using cluster analysis and compare the outcomes among the identified subgroups.

Methods: We enrolled patients with PMR who were diagnosed at Okayama University Hospital, Japan between 2006 and 2017, met the 2012 European League Against Rheumatism/American College of Rheumatology provisional classification criteria for PMR, and were treated with glucocorticoids. Hierarchical cluster analysis using variables selected by principal component analysis was performed to identify the clusters. Read More

Asian Pac J Cancer Prev 2019 07 1;20(7):2079-2085. Epub 2019 Jul 1.

Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Rai, Thailand. Email:

Background: The prognosis and management of primary thrombocytosis (PT) and secondary thrombocytosis (ST) are different. This study aims to evaluate the role of platelet function tests by light transmission platelet aggregometry (LTA), plasma von Willebrand factor antigen (vWF:Ag), ristocetin cofactor activity (vWF:RCo) and inflammatory markers [erythrocyte sedimentation rate (ESR), C-reactive protein (CRP)] for the differentiation between PT and ST. Methods: This prospective study was carried out in patients with platelet counts greater than 450 x 109/L. Read More

BMC Neurol 2019 Jul 18;19(1):169. Epub 2019 Jul 18.

Kantonsspital Graubuenden, Internal medicine, Department of Hematology and Oncology, Loestr. 170, 7000, Chur, CH, Switzerland.

Background: Cerebral salt wasting (CSW) is a rare metabolic disorder with severe hyponatremia and volume depletion usually caused by brain injury like trauma, cerebral lesion, tumor or a cerebral hematoma. The renal function is normal with excretion of very high amounts of sodium in the urine. Diagnosis is made by excluding other reasons for hyponatremia, mainly the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Read More

Pan Afr Med J 2019 10;32:175. Epub 2019 Apr 10.

Gaziantep University Faculty of Medicine, Pediatric Hematology and Oncology, Turkey.

Thrombocytosis is a frequently seen condition during childhood. While it usually develops secondarily due to reasons such as infection or anemia, it may rarely develop due to clonal causes. Thrombocytosis becomes a life-threatening condition by causing severe complications such as hemorrhage and thrombosis development. Read More

J Orthop Case Rep 2019 Jan-Feb;9(1):41-44

Department of Orthopaedics and Traumatology, Istanbul University Istanbul Medical Faculty, Istanbul, Turkey.

Introduction: Transient osteoporosis(TO), also known as bone marrow edema syndrome, is characterized by marrow edema which causes increasing of intramedullary pressure. Among the other causes, such as 3rdthird-trimester pregnancy, impaired circulation may also be caused by changes in normal blood counts such as thrombocytosis. There are multiple reports in the literature of secondary femoral head TO transient osteoporosis; however, there is no case report of femoral head TO transient osteoporos is specifically secondary to essential thrombocytosis (ET) in literature. Read More

Clin Lymphoma Myeloma Leuk 2019 08 1;19(8):e489-e495. Epub 2019 Apr 1.

Department of Human Pathology, University of Messina, Messina, Italy.

Background: Despite the important progress in the research of myeloproliferative neoplasms (MPN), treatment options are still limited. Currently, a cytoreductive approach is the backbone treatment, with hydroxyurea (HU) being the most important agent. However, this drug is not always well-tolerated and has been questionably linked to a potential leukemogenic effect. Read More

Cureus 2019 Mar 21;11(3):e4286. Epub 2019 Mar 21.

Internal Medicine, The University of Arizona, Tucson, USA.

Plasma cell neoplasms are usually associated with normal or decreased platelet count. The association of thrombocytosis and multiple myeloma is exceedingly rare, with only six such cases reported in the literature until now. Differentiating clonal from secondary causes of thrombocytosis can be extremely difficult, yet the distinction has important therapeutic implications. Read More

Blood 2019 07 31;134(4):341-352. Epub 2019 May 31.

Hematology Division, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD.

Since its discovery, polycythemia vera (PV) has challenged clinicians responsible for its diagnosis and management and scientists investigating its pathogenesis. As a clonal hematopoietic stem cell (HSC) disorder, PV is a neoplasm but its driver mutations result in overproduction of morphologically and functionally normal blood cells. PV arises in an HSC but it can present initially as isolated erythrocytosis, leukocytosis, thrombocytosis, or any combination of these together with splenomegaly or myelofibrosis, and it can take years for a true panmyelopathy to appear. Read More

J Surg Res 2019 10 21;242:296-303. Epub 2019 May 21.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address:

Background: Solid tumors are a common cause of secondary (reactive) thrombocytosis, a paraneoplastic syndrome that is also a prognostic factor for various cancers. However, cutoff values for platelet count specific to gastric cancer and their prognostic roles are unknown.

Methods: We retrospectively analyzed records of 4643 patients with gastric cancer who underwent radical surgery from 2007 to 2010. Read More

Cureus 2019 Mar 11;11(3):e4218. Epub 2019 Mar 11.

Hematology-Oncology, St. Barnabas Hospital Health System, Bronx, USA.

Iron deficiency anemia is an unusual etiology of ischemic stroke in the adult population. Only a few case reports exist describing this rare cause of cerebrovascular accident due to low circulating levels of oxygen. To the best of our knowledge, we believe we have described here the first patient presenting with an ischemic stroke secondary to severe anemia without an obvious source of blood loss, evidence of thrombus formation, or associated thrombocytosis. Read More

Respir Res 2019 May 8;20(1):86. Epub 2019 May 8.

Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 1830 E. Monument St. 5th Floor, Baltimore, MD, USA.

Background: Platelet count is a prognostic indicator in the general population and elderly. Thrombocytosis during acute exacerbation of COPD (AECOPD) has been associated with mortality; however, the relationship between platelet count and mortality in stable COPD is unknown.

Methods: We performed post hoc secondary analysis on a subsample of 1797 patients in the Study to Understand Mortality and Morbidity in COPD (SUMMIT) who had blood samples drawn at baseline. Read More

J Neurol 2019 Aug 2;266(8):1869-1878. Epub 2019 May 2.

Department of Neurology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Background: JAK2 V617F mutation increases the risk of thrombosis, and both ischemic and hemorrhagic strokes can occur in essential thrombocythemia (ET). The mechanisms underlying ischemic stroke in ET are diverse, and hemorrhagic stroke has rarely been reported in ET.

Methods: Among 627 stroke patients, those identified as having ET were investigated retrospectively. Read More

Gastroenterology Res 2019 Apr 7;12(2):96-99. Epub 2019 Apr 7.

Department of Medicine, Bronxcare Hospital Center, Bronx, NY 10457, USA.

Hepatocellular carcinoma (HCC) affects more than half a million people worldwide each year. Paraneoplastic syndromes associated with HCC include erythrocytosis, hypercalcemia, hypercholesterolemia, hypoglycemia and thrombocytosis. Thrombocytosis is a rare paraneoplastic syndrome in HCC mediated by thrombopoietin (TPO) production. Read More

Curr Neurol Neurosci Rep 2019 04 22;19(6):27. Epub 2019 Apr 22.

Women's College Hospital Centre for Headache, Division of Neurology, University of Toronto, 76 Grenville St., Toronto, Ontario, M5S 1B2, Canada.

Purpose Of Review: Headaches in pregnancy are a frequent cause of worry for both patients and healthcare providers. Physiological changes during this period increase the risk of a number of secondary headache disorders, and often also have an impact on primary headache disorders. This article reviews recent research into distinguishing worrisome vs non-worrisome headache presentations during pregnancy. Read More

Eur J Haematol 2019 Jun 25;102(6):504-508. Epub 2019 Apr 25.

Rappaport Faculty of Medicine, Technion, Haifa, Israel.

Objective: Approximately 10% of Philadelphia (Ph)-negative myeloproliferative neoplasms (NPM) are diagnosed at young adulthood. We aim to define the features of this group.

Methods: A multicenter retrospective study, including patients 18-45 years of age, diagnosed with Ph-negative MPN between 1985 and 2017. Read More

Clin Transl Oncol 2019 Dec 2;21(12):1644-1653. Epub 2019 Apr 2.

Division of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy.

Purpose: The purpose of this study was to evaluate the prognostic role of thrombocytosis in patients with synchronous colorectal liver metastases (CRLM).

Methods: Retrospective analysis of patients who underwent surgery for colorectal cancer with synchronous CRLM at the Division of General and Hepatobiliary Surgery, University of Verona Hospital Trust between 2005 and 2016.

Results: One hundred and ninety-six patients met the inclusion criteria. Read More

Ultrastruct Pathol 2019 1;43(1):94-98. Epub 2019 Apr 1.

b Department of Histology, Cerrahpasa Faculty of Medicine , Istanbul University-Cerrahpasa , Istanbul , Turkey.

Hermansky-Pudlak syndrome (HPS) is an autosomal recessive disorder consisting of oculocutaneous albinism, platelet storage pool deficiency, and lysosomal accumulation of ceroid lipofuscin. The storage pool deficiency of HPS is associated with the lack of dense bodies in the platelets, resulting in impaired response in the secondary phase of aggregation. Patients with HPS have normal coagulation tests; however, their bleeding time is usually prolonged despite normal or increased platelet counts. Read More

Biol Blood Marrow Transplant 2019 06 28;25(6):e204-e208. Epub 2019 Mar 28.

University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

We aimed to validate the MYelofibrosis SECondary to PV and ET prognostic model (MYSEC-PM) in 159 patients with myelofibrosis secondary to polycythemia vera (PV) and essential thrombocythemia (ET) from the European Society for Blood and Marrow Transplantation registry undergoing transplantation from matched siblings or unrelated donors. Furthermore, we aimed to test its prognostic performance in comparison with the Dynamic International Prognostic Scoring System (DIPSS). Score performance was analyzed using the concordance index (C): the probability that a patient who experienced an event had a higher risk score than a patient who did not (C > . Read More

Expert Rev Hematol 2019 05 27;12(5):367-373. Epub 2019 Apr 27.

b Department of Women's and Children's Health, Pediatric Hemato-Oncology , University of Padova , Padova , Italy.

Introduction: Essential thrombocythemia (ET) is a disease which is extremely rare in children. Only recently, data on pediatric ET have become available. Areas covered: In children with sustained platelet count over 450 x 10/L, secondary thrombocytosis must be ruled out. Read More

BMJ Case Rep 2019 Mar 22;12(3). Epub 2019 Mar 22.

Sanz Medical Centre, Laniado Hospital, Netanya, Israel.

An elderly patient who presented with recent recurrent falls was admitted, reporting inability to stand and recent acute diarrhoeal illness. Paraparesis was diagnosed but extensive investigations did not elucidate its cause. He had atherosclerotic cardiac and vascular disease, diabetes, hypertension, chronic kidney disease and pancreatectomy/splenectomy for a lesion that turned out to be benign. Read More

Platelets 2019 13;30(8):1042-1046. Epub 2019 Feb 13.

Department of Microbiology and Immunology, Medical University of South Carolina , Charleston , SC , USA.

Cancer is a chronic inflammatory state which is often associated with increased platelet counts. Cancer cells induce thrombopoiesis and activate platelets, which in turn facilitate cancer invasion and metastasis. In this study, we investigate the correlation between platelet counts with each of stage and overall survival in melanoma. Read More

Ter Arkh 2018 Aug;90(7):23-29

National Research Center for hematology, Moscow, Russia.

Aim: A comparative evaluation of the effectiveness of different therapeutic strategies in patients with polycythemia vera (PV) and essential thrombocythemia (ET).

Materials And Methods: Patients with PV or ET, diagnosed according to the criteria WHO 2016 were included in the study. The primary endpoint - 6 months of therapy (clinical-hematological and molecular responses). Read More

Nihon Hinyokika Gakkai Zasshi 2018 ;109(1):45-49

Departments of Pathological Diagnostics, Yamagata City Hospital SAISEIKAN.

A 72-year-old woman underwent computed tomography (CT) to identify the underlying cause of thrombocytosis. The CT showed a bladder tumor. Urine cytology was negative. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1117-1119

Department of Rheumatology and Immunology,Peking University First Hospital, Beijing 100034, China.

A 52-year-old man was referred to our department with a 2-year history of polyarthritis. He was diagnosed as gout due to acute arthritis of bilateral feet dorsum 2 years ago,but he didn't receive any standard treatment. 1 year ago,there were more and more joints evolved during the gout attack, and many subcutaneous nodules occurred. Read More

Semin Hematol 2018 10 5;55(4):248-255. Epub 2018 Jun 5.

Institute of Hematology "L. and A. Seràgnoli", Sant'Orsola-Malpighi University Hospital, Bologna, Italy.

Recently, the myelofibrosis secondary to PV and ET prognostic model (MYSEC-PM) was introduced to assess prognosis in myelofibrosis (MF) secondary to polycythemia vera and essential thrombocythemia (post-PV and post-ET MF), replacing the International Prognostic Scoring System (IPSS) and/or Dynamic IPSS (DIPSS) that was applied for primary MF (PMF). In a cohort of 421 ruxolitinib (RUX)-treated patients (post-PV and post-ET MF: 44.2%), we evaluated the following: (1) disease phenotype, responses, and toxicity to RUX; and (2) performance of the MYSEC-PM in post-PV or post-ET MF. Read More

Eur J Haematol 2019 Mar 10;102(3):227-234. Epub 2019 Jan 10.

Department of Haematology, Odense University Hospital, Odense, Denmark.

Objective: Pulmonary hypertension (PH) has been reported to be associated with myeloproliferative neoplasms (MPN), affecting 5%-48% of MPN patients. With the aims to describe the prevalence of PH in Ph-MPN patients and explore the cause in identified subjects, we performed a prospective cohort study of Ph-MPN patients.

Method: Transthoracic echocardiography (TTE) was performed on all patients. Read More

BMC Cancer 2018 Nov 12;18(1):1094. Epub 2018 Nov 12.

Colorectal Surgery Unit, Department of Surgical Sciences, University of Cagliari, Cagliari, Italy.

Background: In patients with locally advanced rectal cancer treated by neoadjuvant chemoradiation, pathological complete response in the surgical specimen is associated with favourable long-term oncologic outcome. Based on this observation, nonoperative management is being explored in the subset of patients with clinical complete response. Whereas, patients with poor response have a high risk of local and distant recurrence, and appear to receive no benefit from standard neoadjuvant chemoradiation. Read More

Am J Hematol 2019 01 25;94(1):87-92. Epub 2018 Nov 25.

H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

A genetically inspired prognostic scoring system (GIPSS) that stratifies primary myelofibrosis (PMF) patients by genetic variants alone was recently proposed. While non-inferior to the dynamic international prognostic scoring system (DIPSS), the lack of overlapping prognostic variables between the models leads to increased risk for disagreement between two valid prognostic models and presents a challenging clinical situation. In an external cohort of 266 molecularly annotated myelofibrosis (MF) patients, we demonstrated that the GIPSS model significantly differentiated between four risk groups (low, int-1, int-2, high) with median OS that was not reached, not reached, 60. Read More

Medicine (Baltimore) 2018 Nov;97(44):e13118

Department of Anesthesiology and Pain Medicine, Ulsan University Hospital, Ulsan University, Republic of Korea.

Rationale: Thrombosis is a major cause of morbidity in the perioperative period. Although many risk factors are known, activated protein C resistance is a prominent risk for thrombosis. Activated protein C resistance frequently occurs with recurrent thromboembolism. Read More

Ned Tijdschr Geneeskd 2018 09 17;162. Epub 2018 Sep 17.

Onze Lieve Vrouwe Gasthuis, afd. Kindergeneeskunde, Amsterdam.

Reactive thrombocytosis (RT; thrombocyte count: > 450 x 109/l) is a condition in which an increase in platelet production, stimulated by cytokines in the bone marrow, is secondary to some condition or circumstance. Although RT does often occur in children, the risk of thromboembolic complications is negligible in this group if they have no other risk factors for thrombosis. In the absence of additional risk factors for thrombosis it seems as though RT in adults does not predispose them to thromboembolic complications either. Read More