7,694 results match your criteria Thrombocytosis Essential


The effect of freeze-dried Carica papaya leaf juice treatment on NS1 and viremia levels in dengue fever mice model.

BMC Complement Altern Med 2018 Dec 5;18(1):320. Epub 2018 Dec 5.

Herbal Medicine Research Center, Institute for Medical Research, Kuala Lumpur, Malaysia.

Background: Carica papaya leaf juice (CPLJ) was well known for its thrombocytosis activity in rodents and dengue patients. However, the effect of CPLJ treatment on other parameters that could contribute to dengue pathogenesis such as nonstructural protein 1 (NS1) production and viremia level have never been highlighted in any clinical and in vivo studies. The aim of this study is to investigate the effect of freeze-dried CPLJ treatment on NS1 and viremia levels of dengue fever mouse model. Read More

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December 2018

Somatic Mutations in Philadelphia Chromosome-Negative Myeloproliferative Neoplasms.

Semin Hematol 2018 Oct 17;55(4):215-222. Epub 2018 Apr 17.

Serviço de Hematologia e Transplantação de Medula, Hospital de Santa Maria, Lisboa, Portugal.

Myeloproliferative neoplasms (MPN) include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). MPN are characterized by clonal proliferation of myeloid progenitors leading to erythrocytosis, thrombocytosis, or leukocytosis, and risk of hemorrhagic and thrombotic events, as well as myelofibrosis and blast transformation. The discovery of somatic mutations in MPN, namely JAK2 V617F, JAK2 exon 12, MPL, and CALR mutations, has permitted a more specific approach to diagnosis and treatment. Read More

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October 2018

[Relationship between Iron Metabolism and Platelet Parameters in Patients with Iron Deficiency Anemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Dec;26(6):1738-1741

Department of Hematology,The First Affiliated Hospital,Harbin Medical University,Harbin 150000,Heilongjiang

Objective: To investigate the relationship between iron metabolism and thrombocytosis.

Methods: iron metabolism indexes , erythrocyte and platelet parameters of iron deficiency anemia patients with thrombocytosis were collected, the correlation of platelet parameters with iron metabolism indexes and erythrocyte parameters was analysed; the difference in erythrocyte,platelet and iron parameters between severe anemia group (hemoglobin<60 g / L) and mild and moderate anemia group (hemoglobin≥60 g / L) were compared; the changes of platelet count before and after treatment were observed.

Results: There was a significant negative correlation between serum iron and platelet count (r=-0. Read More

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December 2018

Platelet miR-28 expression level and thrombocytosis in MPN patients.

Int J Lab Hematol 2018 Nov 27. Epub 2018 Nov 27.

Department of Health, Krasnoyarsk Branch of the "National Research Center for Hematology", Krasnoyarsk, Russian Federation.

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November 2018

Association of pretreatment thrombocytosis with prognosis in ovarian cancer: a systematic review and meta-analysis.

J Gynecol Oncol 2018 Sep 10. Epub 2018 Sep 10.

Department of Gynecology, the Third Affiliate Hospital of Sun Yat-Sen University, Guangzhou, China.

Objective: To investigate the association between pre-treatment thrombocytosis and prognosis in patients with ovarian cancer (OC).

Methods: PubMed, EMBASE, and the Cochrane Library were searched for articles regarding the prognosis of OC patients with pre-treatment thrombocytosis by the end of March 2018. Pooled estimates for overall survival (OS) and progression-free survival (PFS) events were calculated as hazard ratios (HRs) either on a fixed or random effect model by Stata 13. Read More

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September 2018

A case of positive myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis.

Turk J Haematol 2018 Nov 23. Epub 2018 Nov 23.

Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.

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November 2018

Cancer-Associated Thrombosis in Cirrhotic Patients with Hepatocellular Carcinoma.

Cancers (Basel) 2018 Nov 16;10(11). Epub 2018 Nov 16.

Gastroenterology and Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, 35128 Padua, Italy.

It is common knowledge that cancer patients are more prone to develop venous thromboembolic complications (VTE). It is therefore not surprising that patients with hepatocellular carcinoma (HCC) present with a significant risk of VTE, with the portal vein being the most frequent site (PVT). However, patients with HCC are peculiar as both cancer and liver cirrhosis are conditions that can perturb the hemostatic balance towards a prothrombotic state. Read More

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November 2018
1 Read

Frequency and etiology of pulmonary hypertension in patients with myeloproliferative neoplasms.

Eur J Haematol 2018 Nov 19. Epub 2018 Nov 19.

Department of Haematology, Odense University Hospital, Denmark.

Objective: Pulmonary hypertension (PH) has been reported to be associated with myeloproliferative neoplasms (MPN), affecting 5-48% of MPN patients. With the aims to describe the prevalence of PH in Ph-MPN patients and explore the cause in identified subjects, we performed a prospective cohort study of Ph-MPN patients.

Method: Transthoracic echocardiography (TTE) was performed on all patients. Read More

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November 2018
4 Reads

A Clinical Prognostic Score to Predict Survival of Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) Patients Receiving First-Line Chemotherapy: A Retrospective Analysis.

Med Sci Monit 2018 Nov 17;24:8264-8271. Epub 2018 Nov 17.

Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning, China (mainland).

BACKGROUND Although several complicated models have been built to evaluate the prognosis of NSCLC patients receiving chemotherapy, simple economic models are still needed to give a preliminary survival assessment of these patients. MATERIAL AND METHODS This study retrospectively assessed the clinical and biological parameters of 223 patients with advanced NSCLC. Univariate and multivariate analyses of overall survival (OS) and progression-free survival (PFS) for the parameters and the prognostic score were assessed. Read More

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November 2018
3 Reads

Splenic embolization for a giant splenic hemangioma in a child: a case report.

BMC Pediatr 2018 Nov 12;18(1):354. Epub 2018 Nov 12.

Department of Pediatrics, Chungbuk National University Hospital, Cheongju, Republic of Korea.

Background: Splenic hemangioma is the most common benign tumor of the spleen. However, it remains a rare medical condition in children. Although the natural course of splenic hemangioma is slow growth, treatment for large splenic hemangiomas has been recommended due to the risk of spontaneous rupture causing life-threating hemorrhage. Read More

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November 2018
8 Reads

Elevated platelet count is a negative predictive and prognostic marker in locally advanced rectal cancer undergoing neoadjuvant chemoradiation: a retrospective multi-institutional study on 965 patients.

BMC Cancer 2018 Nov 12;18(1):1094. Epub 2018 Nov 12.

Colorectal Surgery Unit, Department of Surgical Sciences, University of Cagliari, Cagliari, Italy.

Background: In patients with locally advanced rectal cancer treated by neoadjuvant chemoradiation, pathological complete response in the surgical specimen is associated with favourable long-term oncologic outcome. Based on this observation, nonoperative management is being explored in the subset of patients with clinical complete response. Whereas, patients with poor response have a high risk of local and distant recurrence, and appear to receive no benefit from standard neoadjuvant chemoradiation. Read More

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November 2018
5 Reads

Marked rebound thrombocytosis in response to glucocorticoids in a patient with acquired amegakaryocytic thrombocytopenia.

J Clin Exp Hematop 2018 Nov 9. Epub 2018 Nov 9.

Acquired amegakaryocytic thrombocytopenia (AATP) is a rare disease characterized by thrombocytopenia and the disappearance of marrow megakaryocytes. A 43-year-old man was admitted because of thrombocytopenia of 1.0×10/L. Read More

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November 2018

Novel models for prediction of benefit and toxicity with FOLFIRINOX treatment of pancreatic cancer using clinically available parameters.

PLoS One 2018 9;13(11):e0206688. Epub 2018 Nov 9.

IIIrd Medical Department with Hematology and Medical Oncology, Hemostaseology, Rheumatology and Infectious Diseases, Oncologic Center, Paracelsus Medical University, Salzburg, Austria.

Background: Despite modern chemotherapy regimens, survival of pancreatic cancer patients remains dismal. Toxicity is a major concern and it is a challenge to upfront identify patients with the highest benefit from aggressive polychemotherapy. We aimed to evaluate ORR and side effects of the FOLFIRINOX regimen, highlighting dose modification and to explore possible prognostic response factors as a clinical tool. Read More

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November 2018
3 Reads

Prefibrotic myelofibrosis: treatment algorithm 2018.

Blood Cancer J 2018 Nov 7;8(11):104. Epub 2018 Nov 7.

FROM Research Foundation, ASST Papa Giovanni XXIII, Bergamo, Italy.

Prefibrotic myelofibrosis (pre-PMF) is a distinct entity among chronic myeloproliferative neoplasm diagnosed according to the revised 2016 WHO classification. The clinical picture is heterogeneous, ranging from isolated thrombocytosis, mimicking essential thrombocythemia (ET), to symptoms of high-risk PMF. Retrospective studies showed that survival of patients with pre-PMF is worse than that of ET and better than overt PMF. Read More

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November 2018
13 Reads

Thrombocytopenia: A prognostic factor for hepatocellular carcinoma patients with portal vein tumor thrombus after hepatectomy.

J Gastroenterol Hepatol 2018 Nov 7. Epub 2018 Nov 7.

Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.

Background And Aim: Portal vein tumor thrombus (PVTT) predicts a poor prognosis in hepatocellular carcinoma (HCC) patients. Platelets (PLTs) play an important role in HCC progression and metastasis. However, the relationship between PLTs and PVTT remains unclear. Read More

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November 2018
1 Read

Malignant peritoneal mesothelioma: clinical aspects, and therapeutic perspectives.

Ann Gastroenterol 2018 Nov-Dec;31(6):659-669. Epub 2018 Sep 14.

Department of Gastroenterology, University Hospital of Ioannina, Faculty of Medicine, School of Health Sciences, University of Ioannina, Greece (Konstantinos H. Katsanos, Dimitrios K. Christodoulou).

Malignant peritoneal mesothelioma (MPM) is a rare disease with a wide clinical spectrum. It arises from the peritoneal lining and commonly presents with diffuse, extensive spread throughout the abdomen and, more rarely, metastatic spread beyond the abdominal cavity. Computed tomography, magnetic resonance imaging and positron-emission tomography are important diagnostic tools used for the preoperative staging of MPM. Read More

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September 2018
4 Reads

Recurrent thrombosis after carotid endarterectomy secondary to activated protein C resistance and essential thrombocytosis: A case report.

Medicine (Baltimore) 2018 Nov;97(44):e13118

Department of Anesthesiology and Pain Medicine, Ulsan University Hospital, Ulsan University, Republic of Korea.

Rationale: Thrombosis is a major cause of morbidity in the perioperative period. Although many risk factors are known, activated protein C resistance is a prominent risk for thrombosis. Activated protein C resistance frequently occurs with recurrent thromboembolism. Read More

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November 2018
2 Reads

Rivaroxaban Induced Thrombocytosis: A Perplexing Clinical Challenge.

Indian J Hematol Blood Transfus 2018 Oct 5;34(4):772-773. Epub 2018 Mar 5.

Institute of Hematology and Transfusion Medicine, Medical College and Hospital, Kolkata, Kolkata, India.

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October 2018

Sushi Domain Containing 2 (SUSD2) inhibits platelet activation and binding to high-grade serous ovarian carcinoma cells.

Platelets 2018 Oct 18:1-4. Epub 2018 Oct 18.

a Department of Biology , Augustana University , Sioux Falls , SD , USA.

Platelets play a central role in primary hemostasis affecting tumor survival and metastases. Tumors induce platelets to aggregate and bind to the cancer cells, resulting in protection from immune surveillance and often leading to thrombocytosis. In ovarian cancer (OvCa), one-third of patients present with thrombocytosis, a diagnosis that correlates with shorter survival. Read More

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October 2018

What is pre-fibrotic myelofibrosis and how should it be managed in 2018?

Br J Haematol 2018 Oct 17;183(1):23-34. Epub 2018 Oct 17.

Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

The 2016 World Health Organization (WHO) classification for myeloproliferative neoplasms (MPN) divided myelofibrosis (MF) into pre-fibrotic (pre-MF) and overt-MF categories. This new classification, particularly the entity pre-MF, has been a subject of discussion between experts. Important questions have been raised in recent years, such as the need for bone marrow trephine for diagnosis; how this is interpreted and the weighting given to it in assigning a diagnosis; determination of prognosis for pre-MF patients; including which scoring system to use and, ultimately, an evidence-based management plan for this group of patients. Read More

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October 2018
10 Reads

Takotsubo Cardiomyopathy Associated with Polycythemia Vera.

Case Rep Cardiol 2018 20;2018:4542925. Epub 2018 Sep 20.

Maharajgunj Medical Campus, Tribhuvan University, Kathmandu, Nepal.

Takotsubo cardiomyopathy is characterized by transient apical ballooning with preserved basal ventricular function triggered by physical or emotional stressors. We present a case of a 75-year-old man referred to our facility for the management of acute myocardial infarction later diagnosed as takotsubo cardiomyopathy. We believe platelet-mediated adrenaline release from massive thrombocytosis might have been the precipitating factor for the pathogenesis of takotsubo cardiomyopathy. Read More

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September 2018
6 Reads

Smoking is associated with increased risk of myeloproliferative neoplasms: A general population-based cohort study.

Cancer Med 2018 Nov 14;7(11):5796-5802. Epub 2018 Oct 14.

National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.

Background: Former studies on smoking as a risk factor for Philadelphia-negative myeloproliferative neoplasms (MPNs) have mainly been carried out in women's cohorts and studies with various definitions of MPNs. Herein, we conducted a cohort study with register-based follow-up of a general population from Denmark, to validate and substantiate prior observations.

Methods: In the Danish Health Examination Survey cohort, we used the Cox proportional-hazards model adjusted for age, sex, body mass index, and level of education, to calculate hazard ratios (HRs), to investigate, whether daily smokers or occasional/ex-smokers had an increased risk of MPNs compared to never-smokers. Read More

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November 2018
6 Reads

A case of monoclonal gammopathy of undetermined significance with abnormal low levels of plasma glycated albumin by M protein.

Clin Chim Acta 2018 Dec 11;487:337-340. Epub 2018 Oct 11.

Department of Internal Medicine, Hakuhokai Central Hospital, Japan. Electronic address:

Background: It is known that an immunoglobulin abnormality affects various clinical laboratory measurements and leads to abnormal values. We experienced a case of monoclonal gammopathy of undetermined significance (MGUS) showing a falsely low plasma glycated albumin (GA) level.

Case Report: The patient was a 75-y-old male who visited our hospital for thrombocytosis identified during a medical checkup. Read More

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December 2018
4 Reads

Pulmonary Artery Catheter Thrombus in a Patient With Essential Thrombocytosis: A Case Report.

A A Pract 2018 Oct 11. Epub 2018 Oct 11.

From the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Essential thrombocytosis (ET) is a rare chronic myeloproliferative disorder characterized by elevated platelet counts. The management of patients with ET undergoing coronary artery bypass graft remains unclear. Often, patients who are deemed "high risk" for thrombotic events receive cytoreductive therapy before surgery, while patients deemed "low risk" do not receive cytoreductive therapy. Read More

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October 2018
6 Reads

A cross-sectional retrospective study to analyze the underlying causes and clinical characteristics of children with reactive thrombocytosis at a Korean tertiary medical center.

Blood Res 2018 Sep 28;53(3):233-239. Epub 2018 Sep 28.

Department of Pediatrics, Keimyung University School of Medicine and Dongsan Medical Center, Daegu, Korea.

Background: Reactive thrombocytosis (RT) is a common condition among children, although no studies have examined the etiology or clinical characteristics of RT among Korean children.

Methods: This retrospective study evaluated children with RT at a single Korean tertiary center during a 10-year period.

Results: RT accounted for 13. Read More

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September 2018
5 Reads

[Risk of thrombosis in reactive thrombocytosis].

Ned Tijdschr Geneeskd 2018 09 17;162. Epub 2018 Sep 17.

Onze Lieve Vrouwe Gasthuis, afd. Kindergeneeskunde, Amsterdam.

Reactive thrombocytosis (RT; thrombocyte count: > 450 x 109/l) is a condition in which an increase in platelet production, stimulated by cytokines in the bone marrow, is secondary to some condition or circumstance. Although RT does often occur in children, the risk of thromboembolic complications is negligible in this group if they have no other risk factors for thrombosis. In the absence of additional risk factors for thrombosis it seems as though RT in adults does not predispose them to thromboembolic complications either. Read More

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September 2018
2 Reads

Non-specific skin purpura.

Malays Fam Physician 2018 31;13(2):39-41. Epub 2018 Aug 31.

MMed Family Medicine USM Klinik Kesihatan Jaya Gading Kuantan, Malaysia.

Essential thrombocythemia is one of the myeloproliferative neoplasms. Palpable purpura is a rare manifestation that may delay diagnosis and treatment. We report a case of essential thrombocythemia in a 50-year-old man, who presented with recurrent thigh pain for the past one year with nonspecific localized purpura. Read More

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August 2018
1 Read

Skewed ratio between type 1 and type 2 calreticulin mutations in essential thrombocytosis patients with concomitant Janus kinase 2 V617F mutation.

Exp Hematol 2018 Oct 4. Epub 2018 Oct 4.

Department of Hematology, Aarhus University Hospital, Aarhus, Denmark. Electronic address:

Detection of somatic mutations in cardinal driver genes is a strong argument for diagnosis in classical Philadelphia-negative myeloproliferative neoplasms (MPNs). Driver mutations in Janus kinase 2 (JAK2), calreticulin (CALR), and XXXX (MPL), are generally considered mutually exclusive, but several reports have suggested that they coexist in a small subgroup of patients. In this study, we retrospectively searched for CALR mutations in 136 suspected MPN patients with low allelic burden (≤5%) JAK2 V617F. Read More

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October 2018
8 Reads

Potential cardiac consequences of thrombocytopenia and thrombocytosis.

Cardiovasc Pathol 2018 Nov - Dec;37:34-38. Epub 2018 Aug 17.

Baylor Scott & White Heart and Vascular Institute, Baylor University Medical Center, Baylor Scott & White Health, Dallas, TX; Department of Pathology, Baylor University Medical Center, Baylor Scott & White Health, Dallas, TX; Department of Internal Medicine (Division of Cardiology), Baylor University Medical Center, Baylor Scott & White Health, Dallas, TX.

This report illustrates the heart in three patients with cardiac hemorrhages associated with extreme thrombocytopenia, and the hearts in three patients with rocks speculated to result at least in part from organization of thrombi possibly related to thrombocytosis in one or more cardiac chambers. Read More

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August 2018
6 Reads

Polycythemia vera and essential thrombocythemia: 2019 update on diagnosis, risk-stratification and management.

Am J Hematol 2018 Oct 3. Epub 2018 Oct 3.

Research Foundation, Papa Giovanni XXIII Hospital, Bergamo, Italy.

Disease Overview: Polycythemia vera (PV) and essential thrombocythemia (ET) are myeloproliferative neoplasms respectively characterized by erythrocytosis and thrombocytosis; other disease features include leukocytosis, splenomegaly, thrombosis, bleeding, microcirculatory symptoms, pruritus, and risk of leukemic or fibrotic transformation. Diagnosis: Bone marrow morphology remains the cornerstone of diagnosis. In addition, the presence of JAK2 mutation is expected in PV while approximately 90% of patients with ET express mutually exclusive JAK2, CALR, or myeloproliferative leukemia mutations. Read More

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October 2018
4 Reads

Evaluation of repeated progression of native coronary artery stenosis by optical frequency domain imaging in a patient with essential thrombocytosis.

J Cardiol Cases 2018 Aug 30;18(2):74-77. Epub 2018 May 30.

Department of Cardiology, Higashi Takarazuka Satoh Hospital, Takarazuka, Japan.

Essential thrombocytosis (ET) is a myeloproliferative disorder with abnormal proliferation of the megakaryocytes and is manifested clinically by the overproduction of dysfunctional platelets, leading to thrombus formation. Therefore, the accurate evaluation of the morphological features for coronary stenosis and initiation of appropriate treatment may be life-saving for ET patients. In this report, we describe a case of the rapid development of repeated stenosis in the native coronary artery in an ET patient, and optical frequency domain imaging confirmed the etiology of the stenoses. Read More

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August 2018
7 Reads

RUNX1-EVI1 induces dysplastic hematopoiesis and acute leukemia of the megakaryocytic lineage in mice.

Leuk Res 2018 Nov 26;74:14-20. Epub 2018 Sep 26.

Department of Hematology and Oncology, Dokkyo Medical University School of Medicine, Tochigi, Japan. Electronic address:

The RUNX1-EVI1 gene generated by the t(3;21) translocation encodes a chimeric transcription factor and is a causative gene in the development of de novo acute megakaryoblastic leukemia and leukemic transformation of hematopoietic stem cell tumors. Heterozygous RUNX1-EVI1 knock-in mice die in utero due to hemorrhage in the central nervous system and spinal cord and complete abolishment of definitive hematopoiesis in the fetal liver. On the other hand, the chimeric knock-in mouse develops acute megakaryoblastic leukemia. Read More

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November 2018
1 Read

Novel methionyl-tRNA synthetase gene variants/phenotypes in interstitial lung and liver disease: A case report and review of literature.

World J Gastroenterol 2018 Sep;24(36):4208-4216

Department of Hepatology, Children's Hospital of Fudan University, Shanghai 201102, China.

Interstitial lung and liver disease (ILLD) is caused by biallelic mutations in the methionyl-tRNA synthetase () gene. To date, no genetic changes other than missense variants were reported in the literature. Here, we report a five-month old female infant with typical ILLD (failure to thrive, developmental delay, jaundice, diffuse interstitial lung disease, hepatomegaly with severe steatosis, anemia, and thrombocytosis) showing novel phenotypes such as kidney stones, acetabular dysplasia, prolonged fever, and extreme leukocytosis. Read More

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September 2018
2 Reads

Thrombocytosis Is a Risk Factor for Surgical Site Infections after Colon Resection: A Prospective Observational Study.

Surg Infect (Larchmt) 2018 Sep 26. Epub 2018 Sep 26.

1 Department of Surgery, Bucharest Emergency Hospital, University of Medicine and Pharmacy "Carol Davila ," Bucharest, Romania .

Background: Colon operations have the highest rate of surgical site infections (SSI) among all general surgical procedures. The aim of this study was to identify the risk factors associated with the development of SSI after colon resection.

Patients And Methods: A prospective study was conducted including patients over 18 years of age who underwent colon resection at a tertiary center. Read More

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September 2018
2 Reads

Prognostic value of JAK2V617F mutation in pseudotumor cerebri associated with cerebral venous sinus thrombosis.

Acta Neurol Scand 2018 Sep 25. Epub 2018 Sep 25.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objectives: To examine the clinical characteristics and prognosis of cerebral venous sinus thrombosis (CVST) that presented as pseudotumor cerebri (PTC) patients with JAK2V617F mutation.

Methods: Medical records of all consecutive patients that presented with PTC and a JAK2V617F mutation who were treated were retrospectively reviewed. Data regarding demographics and ocular presenting symptoms and signs, neurological signs, hematological factors treatment, and prognosis were collected. Read More

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September 2018
6 Reads

Extreme reactive thrombocytosis in an infant: Much ado about nothing?

Pediatr Blood Cancer 2019 Jan 24;66(1):e27467. Epub 2018 Sep 24.

Unit of Hematology, Department of Pediatrics, Hospital Santa Maria (CHLN), Lisbon, Portugal.

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January 2019

Thrombocytosis and portal vein thrombosis after splenectomy for paediatric haemolytic disorders: How should they be managed?

J Paediatr Child Health 2018 Nov 23;54(11):1184-1188. Epub 2018 Sep 23.

Department of Paediatric Surgery, Wellington Hospital, Wellington, New Zealand.

Splenectomy is indicated in selected children with haemolytic anaemia. Postoperatively, thrombocytosis occurs in at least 80% and is one of the factors implicated in the development of acute portal venous thrombosis after splenectomy in adults. A literature review shows that children are also at risk of this complication, but the incidence is low. Read More

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November 2018
1 Read

Hemostatic responses to exercise, dehydration, and simulated bleeding in heat-stressed humans.

Am J Physiol Regul Integr Comp Physiol 2018 Sep 19. Epub 2018 Sep 19.

Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, United States.

Heat stress followed by an accompanying hemorrhagic challenge may influence hemostasis. We tested the hypothesis that hemostatic responses are increased by passive heat stress, and exercise-induced heat stress, each with accompanying central hypovolemia to simulate a hemorrhagic insult. In Aim 1, subjects were exposed to passive heating or normothermic time control, each followed by progressive lower-body negative pressure (LBNP) to pre-syncope. Read More

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September 2018
11 Reads

Thrombocytosis as a Marker for Postoperative Complications in Colorectal Surgery.

Gastroenterol Res Pract 2018 26;2018:1978639. Epub 2018 Aug 26.

Department of Surgery, Morriston Hospital, Heol Maes Eglwys, Morriston, Swansea SA6 6NL, UK.

Background: Blood platelet measurement is a widely available and inexpensive test that is performed routinely. Platelets are thought to act by inducing inflammation and play a role in clotting and antimicrobial defence. A postoperative rise in the platelet count (thrombocytosis) is often dismissed as an incidental finding, but there is growing evidence to suggest that it may act as an indicator to underlying pathology. Read More

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August 2018
8 Reads

Progressive splenomegaly and mild thrombocytosis in beta-thalassaemia trait and coexisting hereditary hemochromatosis: possible confounders for a subsequent hematological diagnosis.

Intern Emerg Med 2018 Sep 14. Epub 2018 Sep 14.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, 20122, Italy.

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September 2018
1 Read

[Cytopenia under topical imiquimod in two patients treated with oral hydroxyurea].

Ann Dermatol Venereol 2018 Sep 11. Epub 2018 Sep 11.

Cabinet de dermatologie, 34, avenue d'Allemagne, 80000 Amiens, France.

Background: Aldara is a topical immunomodulatory treatment. The risks of systemic passage are minimal. There have been rare reports of systemic adverse effects. Read More

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September 2018
1 Read

Perspectives on interferon-alpha in the treatment of polycythemia vera and related myeloproliferative neoplasms: minimal residual disease and cure?

Semin Immunopathol 2018 Sep 10. Epub 2018 Sep 10.

Department of Hematology, Zealand University Hospital, Sygehusvej 10, 4000, Roskilde, Denmark.

The first clinical trials of the safety and efficacy of interferon-alpha2 (IFN-alpha2) were performed about 30 years ago. Since then, several single-arm studies have convincingly demonstrated that IFN-alpha2 is a highly potent anti-cancer agent in several cancer types but unfortunately not being explored sufficiently due to a high toxicity profile when using non-pegylated IFN-alpha2 or high dosages or due to competitive drugs, that for clinicians at first glance might look more attractive. Within the hematological malignancies, IFN-alpha2 has only recently been revived in patients with the Philadelphia-negative myeloproliferative neoplasms-essential thrombocytosis, polycythemia vera, and myelofibrosis (MPNs)-and in patients with chronic myelogenous leukemia (CML) in combination with tyrosine kinase inhibitors. Read More

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September 2018
7 Reads

Predictive risk factors for complicated pneumonia in Malaysian children.

J Paediatr Child Health 2018 Sep 9. Epub 2018 Sep 9.

Department of Paediatrics, University of Malaya, Kuala Lumpur, Malaysia.

Aim: To investigate baseline characteristics associated with complicated community-acquired pneumonia (CAPc) in Malaysian children. CAPc, such as pleural effusion and/or empyema, is on the rise, especially in Southeast Asian children, and the reasons for this are unknown.

Methods: A retrospective study was conducted on all children aged 2-16 years who were admitted to the University Malaya Medical Centre with community-acquired pneumonia between 2012 and 2014. Read More

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September 2018
7 Reads
1.190 Impact Factor

An elusive case of digital ischemia in a patient with Rheumatoid Arthritis.

Pak J Med Sci 2018 Jul-Aug;34(4):1024-1026

Dr. Asif Jan Muhammad, MBBS, MCPS, MRCP (UK). Medicine Department, Patel Hospital, ST-18, Block-4, Gulshan-e-Iqbal, Karachi, Pakistan.

Essential thrombocytosis (ET) has rarely been reported with autoimmune rheumatic disorders. We report a case of young female, diagnosed case of Rheumatoid arthritis (RA), who had been overlooked for her raised platelet counts. Later her symptoms of impending digital gangrene led to an active search for her thrombocytosis. Read More

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September 2018
8 Reads

Lenalidomide induced durable remission in a patient with MDS/MPN-with ring sideroblasts and thrombocytosis with associated 5q- syndrome.

Leuk Res Rep 2018 24;10:37-40. Epub 2018 Aug 24.

Department of Medicine, Texas Tech University Health Sciences Center Paul L. Foster School of Medicine, El Paso, TX, USA.

We describe a patient with MDS/MPN with ring sideroblasts and thrombocytosis who had deletions of long arm of chromosome 5 (5q-) and chromosome 20 (20q-). Molecular studies showed an exon 9, frame shift mutation in the calreticulin (CALR) gene, and absence of mutations in JAK2, MPL, SETBP1 or SF3B1. Treatment with lenalidomide resulted in durable clinical remission which has lasted 2 years. Read More

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August 2018
1 Read

The Platelet Count and its Implications in Sickle Cell Disease Patients Admitted for Intensive Care.

Indian J Crit Care Med 2018 Aug;22(8):585-590

Department of ICU and Anesthesiology, Salmaniya Medical Complex, Manama, Bahrain.

Background And Aims: In sickle cell disease (SCD) patients admitted for intensive care, evaluation of platelet counts in different types of sickle cell complications and its prognostic relevance are not well-studied. Illuminating these aspects were the objectives of this study.

Materials And Methods: A chart review of 136 adult SCD patients consecutively admitted to our Intensive Care Unit (ICU) was done. Read More

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August 2018
7 Reads

Utilizing Whole-Exome Sequencing to Characterize the Phenotypic Variability of Sickle Cell Disease.

Genet Test Mol Biomarkers 2018 Sep 5;22(9):561-567. Epub 2018 Sep 5.

4 Department of Pediatrics, King Abdullah Specialist Children's Hospital , King Abdullah International Medical Research Centre, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia .

Background: Sickle cell disease (SCD) is a monogenic disease that has wide variety of phenotypes with both and environmental factors contributing to its severity.

Methods: We performed whole-exome sequencing (WES) in 22 Saudi SCD patients to identify variants that could explain differences in disease phenotypes. All variants, except those that were benign and likely benign, described in the ClinVar database, were considered in our analysis. Read More

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September 2018
8 Reads