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Iran J Immunol 2022 Jun;19(2):10

Department of Obstetrics and Gynecology, Zhejiang Provincial People's Hospital, Hangzhou 310016, Zhejiang, China.

Background: Systemic lupus erythematosus (SLE) is most likely to occur during the first and second trimesters of pregnancy. There were few studies focused on the new-onset SLE during the late pregnancy or puerperium. SLE has been considered an important cause of thrombocytopenia. Read More

Indian J Thorac Cardiovasc Surg 2022 Jul 12;38(Suppl 2):290-299. Epub 2021 Oct 12.

Lung Transplant Program, University of Texas Southwestern Medical Center, 5939 Harry Hines Blvd. Suite 603, Dallas, TX 75235-8550 USA.

Lung transplantation (LT) is a viable therapeutic option in the treatment of advanced lung disease. With improvements in post-transplant survival, complications involving different organ systems after LT are increasingly seen. While non-infectious, extrapulmonary complications after LT are not frequently responsible for early post-transplant mortality, they significantly impact the quality of life and long-term survival. Read More

Cureus 2022 May 18;14(5):e25096. Epub 2022 May 18.

Internal Medicine, BronxCare Health System, Bronx, USA.

Atypical hemolytic uremic syndrome (HUS) is a rare but severe form of thrombotic microangiopathies (TMAs) that affects both children and adults. The clinical presentation is usually nonspecific, including a broad spectrum of symptoms ranging from abdominal pain, confusion, diarrhea, fatigue, irritability, hypertension, and lethargy. We present a case of a 36-year-old woman with medical comorbidities of asthma and pulmonary embolism who presented to our hospital in the 36th week of her pregnancy for preterm premature rupture of the membranes. Read More

Chin Med J (Engl) 2022 04 20;135(8):887-889. Epub 2022 Apr 20.

Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, Zhengzhou, Henan 450003, China.

Indian J Crit Care Med 2022 May;26(5):639-640

Department of Anaesthesiology, MPMMCC, Varanasi, Uttar Pradesh, India.

HELLP is a syndrome characterized by hemolysis, elevated liver enzymes, and low platelets. It is a rare complication of pregnancy and is usually associated with pre-eclampsia. However, 10-20% cases of HELLP can present without hypertension. Read More

Medicine (Baltimore) 2022 Jun 17;101(24):e29403. Epub 2022 Jun 17.

Nursing Graduate Program, Federal University of Rio Grande do Norte, Natal, Brazil.

Introduction: Uterine cervix tumors have an invasive nature, with the capacity to proliferate to surrounding organs such as the vagina, bladder, and rectum, as well as the capacity for dissemination and involvement of structures distant from its place of origin. According to the International Federation of Gynecology and Obstetrics, patients with stages IB I, IB I microscopic (small dimension <4 cm) are indicated for radiotherapy or adjuvant chemoradiotherapy with cisplatin (40 mg/m2). However, cisplatin has side effects such as hematological implications (anemia, neutropenia, and thrombocytopenia), gastrointestinal disorders (nausea, vomiting, diarrhea, constipation), and fatigue. Read More

Haematologica 2022 06 16. Epub 2022 Jun 16.

Weill Cornell Medicine - Division of Hematology and Medical Oncology, 1300 York Ave. A603A, New York, New York 10065.

This article summarizes our approach to the diagnosis, secondary ITP, and choice of second line options in patients with immune thrombocytopenic (ITP). We very briefly summarize first-line treatment and then utilize a case-based approach. We will first explore persistent-chronic ITP in a younger female. Read More

Case Rep Hematol 2022 6;2022:7845786. Epub 2022 Jun 6.

Joan C. Edwards School of Medicine at Marshall University, Huntington, WV 25701, USA.

Cerebral venous sinus thrombosis (CVST) is a rare but potentially life-threatening cause of stroke. Several risk factors have been identified including hypercoagulable state, malignancy, use of oral contraceptives, pregnancy, head injury, infection, and prothrombotic states such as heparin-induced thrombocytopenia (HIT). HIT is a prothrombotic state leading to thrombosis in several distinct locations including CVST requiring prompt discontinuation of heparin and initiation of nonheparin anticoagulation to prevent catastrophic consequences. Read More

J Gynecol Obstet Hum Reprod 2022 Jun 7;51(7):102422. Epub 2022 Jun 7.

Obstetrics and Fetal medicine Unit, CHRU of Nancy, Nancy, France; Université de Lorraine, Inserm, IADI, F-54000 Nancy, France.

In pregnant women, Thrombotic Thrombocytopenic Purpura (TTP) mimics severe preeclampsia because of the overlapping of these symptoms. We report the case of a 28-years-old woman who presented severe thrombocytopenia (platelets at 34 G/L) at 31 gestational weeks. The day after, she showed anaemia, worsening thrombocytopenia (platelets at 6 G/L) and an isolated increase of AST (91 UI/L). Read More

Am J Obstet Gynecol 2022 Jun 6. Epub 2022 Jun 6.

Division of Child and Adolescent Psychology, Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, the Netherlands.

Background: Children with fetal and neonatal alloimmune thrombocytopenia face increased risk of intracranial hemorrhage potentially leading to developmental impairment. To prevent intracranial hemorrhage, pregnant women with alloantibodies against fetal platelets are often treated with intravenous immunoglobulin. Intravenous immunoglobulin seems effective in vastly reducing the risk of fetal or neonatal bleeding complications. Read More

Best Pract Res Clin Anaesthesiol 2022 May 10;36(1):107-121. Epub 2022 Feb 10.

Columbia University Irving Medical Center, United States of America; Columbia University, United States of America. Electronic address:

Preeclampsia is a severe manifestation of maternal hypertensive disease affecting 2-8% of pregnancies. The disease places women at risk of women at risk of life-threatening events, including cerebral hemorrhage, pulmonary edema, acute kidney injury, hepatic failure or rupture, disseminated intravascular coagulation, eclampsia, and placental abruption. In addition to the maternal disease burden, increased fetal morbidity and mortality occurs due to iatrogenic preterm delivery, fetal growth restriction, and placental abruption. Read More

Neoreviews 2022 Jun;23(6):e429-e433

Department of Surgery, Division of Pediatric Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, TX.

Ann Med Surg (Lond) 2022 May 15;77:103636. Epub 2022 Apr 15.

Endocrine Unit, Internal Medicine Department, KFMMC, Dhahran, 31932, Saudi Arabia.

Background: Hypertriglyceridemia is a medical condition defined as fasting triglyceride level more than 150 mg/dl. It could be due to either familial or acquired cause as in obesity, metabolic syndrome, diabetes mellitus type 2, alcohol consumption, decrease exercise or drug affects. Drugs such as corticosteroids rarely induced hypertriglyceridemia, for that we are reporting this case. Read More

J Clin Med 2022 May 19;11(10). Epub 2022 May 19.

Clinical Immunology and Transfusion Medicine, Office for Medical Services, Region Skåne, SE-221 85 Lund, Sweden.

Hemolytic disease of the fetus and newborn (HDFN), as well as fetal and neonatal alloimmune thrombocytopenia (FNAIT), represent two important disease entities that are caused by maternal IgG antibodies directed against nonmaternally inherited antigens on the fetal blood cells. These antibodies are most frequently directed against the RhD antigen on red blood cells (RBCs) or the human platelet antigen 1a (HPA-1a) on platelets. For optimal management of pregnancies where HDFN or FNAIT is suspected, it is essential to determine the RhD or the HPA-1a type of the fetus. Read More

Cells 2022 05 13;11(10). Epub 2022 May 13.

Center for Functional Genomics of Microbes, Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, 17489 Greifswald, Germany.

Group B streptococci (GBS) cause a range of invasive maternal-fetal diseases during pregnancy and post-partum. However, invasive infections in non-pregnant adults are constantly increasing. These include sepsis and streptococcal toxic shock syndrome, which are often complicated by systemic coagulation and thrombocytopenia. Read More

Indian J Crit Care Med 2021 Dec;25(Suppl 3):S261-S266

Department of Critical Care Medicine, Jupiter Hospital, Mumbai, Maharashtra, India.

Hypertensive disorders of pregnancy can be classified as chronic hypertension (present before pregnancy), gestational hypertension (onset after 20 weeks of pregnancy), and preeclampsia (onset after 20 weeks of pregnancy, along with proteinuria and other organ dysfunction). Preeclampsia and related disorders are a major cause of maternal and fetal morbidity and mortality. Preeclampsia is believed to result from an angiogenic imbalance in the placenta circulation. Read More

Lupus Sci Med 2022 05;9(1)

Department of Clinical Epidemiology, The First Hospital of Jilin University, Changchun, China

Objectives: Based on clinical and laboratory indicators, this study aimed to establish a multiparametric nomogram to assess the risk of refractory cases of SLE-related thrombocytopenia (SLE-related TP) before systematic treatment.

Methods: From June 2012 to July 2021, a dual-centre retrospective cohort study of prospectively collected data of patients with SLE-related TP was conducted. The cohort data were divided into a developing set, internal validation set and external validation set. Read More

Cureus 2022 Apr 16;14(4):e24196. Epub 2022 Apr 16.

Department of Obstetrics and Gynecology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, IND.

Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome is a dangerous complication of pregnancy amounting to significant mortality and morbidity. While conducting a cesarean delivery for such cases special care and consideration have to be taken in order to prevent maternal mortality. Thrombocytopenia is a significant abnormality that has to be weighed before induction in cases of HELLP syndrome with no clear cut-off value for the administration of neuraxial anesthesia. Read More

J Thromb Thrombolysis 2022 May 17. Epub 2022 May 17.

University of California, San Francisco San Francisco VA Medical Center, San Francisco, CA, USA.

Thromboembolism is a common and deadly consequence of COVID-19 infection for hospitalized patients. Based on clinical evidence pre-dating the COVID-19 pandemic and early observational reports, expert consensus and guidance documents have strongly encouraged the use of prophylactic anticoagulation for patients hospitalized for COVID-19 infection. More recently, multiple clinical trials and larger observational studies have provided evidence for tailoring the approach to thromboprophylaxis for patients with COVID-19. Read More

Pan Afr Med J 2022 22;41:154. Epub 2022 Feb 22.

Unit of Obstetrics and Gynaecology, Department of Primary Health Care Sciences, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe.

Malaria in pregnancy is associated with significant morbidity and mortality, and requires early diagnosis and intervention. Plasmodium falciparum is responsible for 98% of malaria cases in Zimbabwe and causes the most severe disease. Abnormal haematological parameters are a frequent finding in patients with malaria; however, they are rarely the sole presenting feature. Read More

Eur J Obstet Gynecol Reprod Biol 2022 Jul 6;274:23-27. Epub 2022 May 6.

Lis Hospital for Women, Tel Aviv Sourasky Medical Center, affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Introduction: A rise in the rate of cesarean delivery (CD) has been found to be associated with a higher length of hospital stay, making it a public health concern. We aimed to evaluate risk factors for prolonged hospitalization following CD.

Methods: A retrospective cohort study, in a single tertiary medical center, was conducted (2011-2019). Read More

J Med Case Rep 2022 May 13;16(1):203. Epub 2022 May 13.

Department of Obstetrics, Perinatal Center, National Hospital Organization Kyushu Medical Center, 1-8-1, Jigyohama Chuo-ku, Fukuoka, 810-8563, Japan.

Background: Gaucher disease is an autosomal recessive inborn error of metabolism that causes disorders of blood, bone, and central nervous system as well as hepatosplenomegaly. We present the case of a carrier of Gaucher disease with gestational thrombocytopenia and anemia that required blood transfusion therapy.

Case Presentation: A 24-year-old Nepalese primipara was diagnosed with idiopathic thrombocytopenia at 12 weeks of gestation. Read More

J Coll Physicians Surg Pak 2022 May;32(5):646-651

Chongqing Key Laboratory of Pediatrics, Chongqing, China.

Objective: To compare the clinical characteristics of necrotizing enterocolitis (NEC) and food protein-induced enterocolitis (FPIES) when both have pneumatosis intestinalis (PI) and to identify them.

Study Design:  Analytical study.

Place And Duration Of Study:  Department of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, China, from January to December 2019. Read More

Aust N Z J Obstet Gynaecol 2022 May 11. Epub 2022 May 11.

Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria, Australia.

Background: Pregnancy represents a time of increased morbidity and mortality for women and their infants. Clinical quality registries (CQRs) collect, analyse and report key healthcare quality indicators for patient cohorts to improve patient care. There are limited data regarding existing CQRs in pregnancy. Read More

Clin Appl Thromb Hemost 2022 Jan-Dec;28:10760296221097379

Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, 256197Wollo University, Dessie, Ethiopia.

Background: Thrombocytopenia is a common hematological abnormality during gestation. Pregnant women with severe thrombocytopenia may be associated with a higher risk of excessive bleeding during or after delivery. Therefore, the main aim of this study was to assess the magnitude and associated factors of thrombocytopenia among pregnant women attending antenatal care services at Dessie comprehensive and specialized hospital, Northeast Ethiopia. Read More

BMC Pediatr 2022 05 10;22(1):262. Epub 2022 May 10.

St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.

Background: Globally, perinatal asphyxia (PNA) is a significant cause of most neonatal deaths. Similarly, the burden of birth asphyxia in Ethiopia remains high (22.52%) and has been noted the second leading cause of neonatal mortality. Read More

Rev Esp Anestesiol Reanim (Engl Ed) 2022 04 7;69(4):245-248. Epub 2022 May 7.

Anestesiología y Reanimación, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.

Atypical uremic haemolytic syndrome is a variant of thrombotic micro-andiopathy characterized by non-autoimmune hemolytic anemia, thrombocytopenia and acute renal failure as a result of excessive activation of the complement. Up to 60% of patients have mutations in the genes that encode the complement system. A disensing factor is required for its manifestation, including gestation. Read More

Rheumatology (Oxford) 2022 May 10. Epub 2022 May 10.

Department of Rheumatology, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing, China.

Objectives: Thrombocytopenia, a frequent clinical manifestation in patients with antiphospholipid syndrome (APS), could be an independent predictor of recurrent thrombotic, obstetrical and severe extra-criteria events.

Methods: This single-center prospective study enrolled 218 consecutive patients diagnosed with primary APS between 2010 to 2021. Thrombocytopenia was defined as a platelet count <100 × 109/L. Read More

Arch Clin Cases 2022 6;9(1):24-28. Epub 2022 Apr 6.

CMH Lahore Medical College, Lahore, Punjab, Pakistan.

We report a case of thrombotic microangiopathy in a postpartum female for which considerable diagnostic uncertainty existed initially regarding the etiology. This case highlights the limitations surrounding PLASMIC scoring criteria for the diagnosis of thrombotic thrombocytopenic purpura (TTP). A 32-year-old woman presented to maternofetal medicine in her third trimester of pregnancy at 32 weeks for a routine follow up and was subsequently found to have elevated blood pressures with proteinuria, and was diagnosed with pre-eclampsia. Read More

Haemophilia 2022 May;28 Suppl 4:11-17

School of Pharmacy and Biomolecular Sciences, Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

Progress in both basic and translational research into the molecular mechanisms of VWD can be seen in multiple fields.

Genetics Of Vwd: In the past several decades, knowledge of the underlying pathogenesis of von Willebrand disease (VWD) has increased tremendously, thanks in no small part to detailed genetic mapping of the von Willebrand Factor (VWF) gene and advances in genetic and bioinformatic technology. However, these advances do not always easily translate into improved management for patients with VWD and low-VWF levels. Read More