4,847 results match your criteria Thrombocytopenia in Pregnancy


[Establishment and one-year evaluation of an internal medicine consultation in a maternity].

Sante Publique 2018 September October;30(5):671-677

Objective: In the obstetric medicine movement and in response to requests for appointments in internal medicine by obstetricians and midwives, we created an internal medicine consultation within the maternity ward of our General Hospital, and provide feedback after 1 year.

Methods: This retrospective descriptive study took place at the Robert Ballanger Intercommunal Hospital Center in Aulnay-sous-Bois in Seine-Saint-Denis (France) between 3rd March 2016 and 9th March 2017, the first year of the internal medicine consultation, one afternoon every 15 days, in the maternity level 2b.

Results: Out of 121 appointments, 93 consultations were conducted for 63 patients. Read More

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http://dx.doi.org/10.3917/spub.186.0671DOI Listing
February 2019

Cryptic conspirators: a conversation about thrombocytopenia and antiphospholipid syndrome.

Curr Opin Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Division of Rheumatology, Department of Internal Medicine, University of Michigan.

Purpose Of Review: Although antiphospholipid syndrome (APS) is best known for conveying increased risk of thrombotic events and pregnancy morbidity, thrombocytopenia is also recognized as a common association. In this review, we will explore the relationship between thrombocytopenia and APS, highlighting our evolving understanding - and persistent knowledge gaps - through clinically oriented questions and answers.

Recent Findings: A history of thrombocytopenia likely portends a more severe APS phenotype (including increased risk of thrombosis). Read More

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http://dx.doi.org/10.1097/BOR.0000000000000595DOI Listing
February 2019
1 Read

Increased biosynthesis and accumulation of cholesterol in maternal plasma, but not amniotic fluid in pre-eclampsia.

Sci Rep 2019 Feb 7;9(1):1550. Epub 2019 Feb 7.

Department of Obstetrics & Gynecology, Seoul National University College of Medicine, Seoul, Korea.

Preeclampsia is one of the most serious complications during pregnancy, defined as development of hypertension during late pregnancy affecting other organ systems (proteinuria, thrombocytopenia, renal insufficiency, liver involvement, cerebral symptoms or pulmonary edema). Preeclampsia is known to be associated with significant dyslipidemia, but the cause or mechanism of this metabolic aberration is not clear. Quantitative analysis of cholesterol precursors and metabolites can reveal metabolic signatures of cholesterol, and provide insight into cholesterol biosynthetic and degradation pathways. Read More

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http://dx.doi.org/10.1038/s41598-018-37757-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367404PMC
February 2019
2 Reads

[Hereditary thrombocytopenia associated with a mutation in the MYH-9 gene. Report of one case].

Rev Med Chil 2018 Sep;146(9):1074-1078

Sección Genética Hospital Clínico, Universidad de Chile, Santiago, Chile.

We report a 51-year-old female who had a first episode of thrombocytopenia at 23 years of age during a pregnancy. At the age of fifty, a hysterectomy was indicated due to a metrorrhagia: a platelet count of 21,000/ul was detected. She was treated with eltrombopag with a good response. Read More

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http://dx.doi.org/10.4067/s0034-98872018000901074DOI Listing
September 2018
1 Read

Acute IgA-Dominant Glomerulonephritis Associated with Syphilis Infection in a Pregnant Teenager: A New Disease Association.

J Clin Med 2019 Jan 18;8(1). Epub 2019 Jan 18.

Department of Pathology, National Institute of Cardiology "Ignacio Chávez", Mexico City 14000, Mexico.

Chronic kidney disease (CKD) is increasingly recognized as a risk factor in pregnancy; the differential diagnosis between CKD and preeclampsia (PE) may be of pivotal importance for pregnancy management and for early treatment of CKD. Acknowledging this connection may be useful also in a wider context, such as in the case reported in this paper, which for the first time describes an association between syphilis infection and IgA-dominant glomerulonephritis. A 16-year-old woman, referred to a general hospital due to a seizure, was found to be unknowingly pregnant. Read More

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http://www.mdpi.com/2077-0383/8/1/114
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http://dx.doi.org/10.3390/jcm8010114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352144PMC
January 2019
7 Reads

Recurrent case of pregnancy-induced atypical haemolytic uremic syndrome (P-aHUS).

BMJ Case Rep 2019 Jan 17;12(1). Epub 2019 Jan 17.

Medicine (Nephrology), Jacobi Medical Center / Albert Einstein College of Medicine, New York City, New York, USA.

Pregnancy-induced atypical haemolytic uremic syndrome (P-aHUS) is a rare condition characterised by microangiopathic haemolytic anaemia, thrombocytopenia and renal failure. It accounts for approximately 7% of total HUS cases. Here, we present a case of recurrent P-aHUS in a 25-year-old Hispanic woman. Read More

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http://dx.doi.org/10.1136/bcr-2018-226571DOI Listing
January 2019
3 Reads

Immune thrombocytopenic purpura presenting with spontaneous gingival haemorrhage in pregnancy.

BMJ Case Rep 2019 Jan 17;12(1). Epub 2019 Jan 17.

Department of Oral and Maxillofacial Surgery, The Queen Elizabeth Hospital, Birmingham, UK.

Gingival bleeding is a common intraoral finding, typically associated with inflamed tissues and periodontal disease. It is easily provoked by periodontal probing or toothbrushing. Spontaneous gingival bleeding rarely occurs and may be the only sign of systemic bleeding problems such as thrombocytopenia, leukaemia or coagulopathy. Read More

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http://dx.doi.org/10.1136/bcr-2018-228309DOI Listing
January 2019
9 Reads

A "miracle" pregnancy outcome of severe placental abruption.

Horm Mol Biol Clin Investig 2019 Jan 17. Epub 2019 Jan 17.

Department of Obstetrics and Gynecology, Sibu Hospital, Ministry of Health Malaysia, 96000 Sibu, Sarawak, Malaysia.

Severe placental abruption is associated with high maternal and perinatal morbidity and mortality. Prompt delivery is usually mandatory in this situation. We report a case of a 33-year-old woman, gravida 5, para 3 + 1, at 26 weeks + 3 days' gestation who had severe placental abruption involving 40% of the placental surface complicated with maternal moderate anaemia and thrombocytopenia. Read More

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http://www.degruyter.com/view/j/hmbci.ahead-of-print/hmbci-2
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http://dx.doi.org/10.1515/hmbci-2018-0059DOI Listing
January 2019
4 Reads

Cerebral Venous Sinus Thrombosis in Systemic Lupus Erythematosus.

Acta Med Indones 2018 Oct;50(4):343-345

Department of Internal Medicine, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.

A 38-year-old woman presented with general weakness and vaginal bleeding. One month prior, she had been diagnosed with Evans syndrome (haemolytic anemia with positive Coombs test and thrombocytopenia) and was given oral steroid as maintenance therapy. Her serology examination was negative for hepatitis B, hepatitis C, and human immunodeficiency virus (HIV). Read More

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October 2018
9 Reads

Three cases of multi-generational Gaucher disease and colon cancer from an Ashkenazi Jewish family: A lesson for cascade screening.

Mol Genet Metab Rep 2019 Mar 4;18:19-21. Epub 2019 Jan 4.

Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

Gaucher disease (GD) is one of the commonest lysosomal storage diseases that is inherited in an autosomal recessive manner and affects 1 in 50,000 to 100,000 people in the general population. The frequency is much higher (1 in 500 to 1000) in people of Ashkenazi Jewish heritage due to a founder effect. GD is caused by decreased or absent activity of β-glucosidase with subsequent accumulation of the substrate glucosylceramide in macrophages due to genetic alterations in the gene. Read More

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http://dx.doi.org/10.1016/j.ymgmr.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321950PMC
March 2019
6 Reads

[Refractory primary immune thrombocytopenia in pregnancy requiring splenectomy and repeated intravenous immunoglobulin therapy].

Rinsho Ketsueki 2018 ;59(12):2574-2577

Third Department of Internal Medicine, Yamaguchi University School of Medicine.

A 30-year-old primigravid woman without a history of thrombocytopenia was referred to our hospital because of severe thrombocytopenia (<1,000 thrombocytes/µl) at 16 weeks of gestation and diagnosed with idiopathic thrombocytopenic purpura (ITP). There was no improvement in the platelet count after treatment with 0.5-1. Read More

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https://www.jstage.jst.go.jp/article/rinketsu/59/12/59_2574/
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http://dx.doi.org/10.11406/rinketsu.59.2574DOI Listing
January 2018
7 Reads

Comprehensive treatment in severe dengue during preterm and term labor: could tocolysis be useful?

J Matern Fetal Neonatal Med 2019 Jan 9:1-6. Epub 2019 Jan 9.

b Clinical Research Center, Fundación Valle Del Lili , Cali , Colombia.

Objective: There is lack of data on the management of severe dengue infection during labor. The objective of this study was to describe our experience in the management of preterm and term labor of pregnant patients with severe dengue infection and thrombocytopenia.

Materials And Methods: We describe patients with dengue infection confirmed by dengue serology or NS1 antigen in Cali, Colombia. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2018.1
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http://dx.doi.org/10.1080/14767058.2018.1554044DOI Listing
January 2019
10 Reads

Circulating antiplatelet antibodies in pregnant women with immune thrombocytopenic purpura as predictors of thrombocytopenia in the newborns.

Platelets 2019 Jan 7:1-5. Epub 2019 Jan 7.

a National Medical Research Center for Cardiology , Ministry of Health , Moscow , Russian Federation.

Newborns from mothers with immune thrombocytopenic purpura (ITP) have a risk of thrombocytopenia due to passage of maternal antiplatelet antibodies into fetal/neonatal circulation. We looked for predictors of neonatal thrombocytopenia (nTP) in pregnant women with ITP. One hundred pregnant women with platelet count <100 × 10/l, no non-immune causes of thrombocytopenia and increased platelet associated IgG (PA-IgG) were included in the study. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1557615DOI Listing
January 2019
6 Reads

Effect of recombinant human thrombopoietin on immune thrombocytopenia in pregnancy in a murine model.

Int Immunopharmacol 2019 Feb 17;67:287-293. Epub 2018 Dec 17.

Department of Hematology, Qilu Hospital, Shandong University, Jinan, China; Shandong Provincial Key Laboratory of Immunohematology, Qilu Hospital, Shandong University, Jinan, China; Leading Research Group of Scientific Innovation, Department of Science and Technology of Shandong Province, Qilu Hospital, Shandong University, Jinan, China. Electronic address:

Primary immune thrombocytopenia (ITP) is a serious medical disorder that has the potential for maternal and fetal mortality. Corticosteroids, intravenous immunoglobulin, or both are the first-line treatments for ITP in pregnancy, but choices are limited if patients fail to respond. Recombinant human thrombopoietin (rhTPO) has been proved effective and safe in management of chronic ITP. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183046
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http://dx.doi.org/10.1016/j.intimp.2018.12.032DOI Listing
February 2019
6 Reads

Presence of Immune Complexes of IgG/IgM Bound to B2-glycoprotein I Is Associated With Non-criteria Clinical Manifestations in Patients With Antiphospholipid Syndrome.

Front Immunol 2018 20;9:2644. Epub 2018 Nov 20.

Immunology Department, Hospital 12 de Octubre, Madrid, Spain.

Antiphospholipid syndrome (APS) is an acquired autoimmune disorder defined by the presence of both clinical (thromboembolic events or pregnancy morbidity) and laboratory (antiphospholipid antibodies, aPL) manifestations. Despite their importance, several clinical manifestations strongly associated with APS such as livedo reticularis (LR), thrombocytopenia, sicca-ophthalmic(sicca), heart, or neurological manifestations are not included in the APS clinical classification criteria. Circulating immune complexes (CIC) formed by Beta-2-glycoprotein I (B2GPI) and aPL (B2-CIC) have been described and their presence has been related with thrombotic events. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256181PMC
November 2018
11 Reads

Refractory Severe Thrombocytopenia during Pregnancy: How to Manage.

Rev Bras Ginecol Obstet 2018 Dec 7;40(12):803-807. Epub 2018 Dec 7.

Department of Anaesthesiology, Centro Hospitalar Lisboa Norte, Lisboa, Portugal.

Thrombocytopenia is the most common hemostatic change in pregnancy, but severe thrombocytopenia is rare. One of the causes, immune thrombocytopenic purpura (ITP), is characterized by increased platelet destruction by immunoglobulin G (IgG) antibodies, presenting a high risk of hemorrhage for the patient, but also for the fetus, since antibodies may cross the placenta. We present the case of a 23-year-old pregnant woman with a history of Langerhans cell histiocytosis of the mandible submitted to surgery and chemotherapy when she was 10 years old, with diagnosis of ITP since then. Read More

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http://dx.doi.org/10.1055/s-0038-1675186DOI Listing
December 2018
4 Reads

Maternal and perinatal outcomes of expectant treatment of severe preeclampsia

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):379-386. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Ginecología y Obstetricia No. 3 “Dr. Víctor Manuel Espinoza de los Reyes Sánchez”, Unidad de Cuidados Intensivos. Ciudad de México, México

Background: In severe preeclampsia (SP), pregnancy interruption is the first recommendation. However, some patients receive expectant treatment.

Objetive: To determine maternal and perinatal results of expectant treatment of SP in the intensive care unit (ICU) of a high-specialty hospital. Read More

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November 2018
21 Reads

TTP: long-term outcomes following recovery.

Authors:
James N George

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):548-552

Hematology-Oncology Section, Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK.

Although risk for relapse may be the greatest concern following recovery from acquired, autoimmune thrombotic thrombocytopenic purpura (TTP), there are multiple other major health issues that must be recognized and appropriately addressed. Depression may be the most common disorder following recovery from TTP and may be the most important issue for the patient's quality of life. Severe or moderate depression has occurred in 44% of Oklahoma Registry patients. Read More

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http://dx.doi.org/10.1182/asheducation-2018.1.548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246011PMC
November 2018
1 Read

Atypical Hemolytic Uremic Syndrome Presenting as Pre-eclampsia in a 24-year-old Woman with Chronic Kidney Disease: Pathogenesis and Genetics.

Cureus 2018 Sep 25;10(9):e3358. Epub 2018 Sep 25.

Internal Medicine, Brookdale University Hospital, New York, USA.

Atypical hemolytic uremic syndrome (aHUS) is a kidney disorder that is frequently unrecognized during its progression, and misdiagnosed with more common etiologies of microangiopathic hemolytic anemia (MAHA): hemolytic uremic syndrome, disseminated intravascular coagulation, and thrombotic thrombocytopenic purpura (TTP). During pregnancy, the diagnosis of aHUS is furthermore challenging. The clinical presentation of aHUS may mimic pre-eclampsia as it occurred to the patient described in the case report. Read More

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http://dx.doi.org/10.7759/cureus.3358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257492PMC
September 2018
3 Reads

ABO antigen levels on platelets of normal and variant ABO blood group individuals.

Platelets 2018 Nov 26:1-7. Epub 2018 Nov 26.

a Blood Center of Zhejiang Province , Hangzhou , China.

Although differential expression of ABO antigens on platelets is related to recipients' platelet recovery and neonatal alloimmune thrombocytopenia in ABO-incompatible transfusion and pregnancy, the expression of ABO antigens on platelets in normal and variant ABO blood group individuals is rarely reported. Here, we analyzed the expression of ABO antigens on platelets in a cohort of 515 individuals with normal and variant ABO. The variants were also genotyped for ABO and/or FUT1 loci to distinguish inherited or acquired ABO variants. Read More

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http://dx.doi.org/10.1080/09537104.2018.1543863DOI Listing
November 2018
5 Reads

Upshaw-Schulman syndrome diagnosed during pregnancy complicated by reversible cerebral vasoconstriction syndrome.

Transfus Apher Sci 2018 Dec 16;57(6):790-792. Epub 2018 Nov 16.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Upshaw-Schulman syndrome (USS) is an inherited type of thrombotic thrombocytopenic purpura (TTP) that is extremely rare, but often diagnosed during pregnancy. Reversible cerebral vasoconstriction syndrome (RCVS) is the transient stenosis of several cerebral arteries that is frequently diagnosed post-partum. We describe a 28-year-old woman with USS complicated by RCVS after delivery that was treated by plasma exchange with a good outcome. Read More

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http://dx.doi.org/10.1016/j.transci.2018.10.023DOI Listing
December 2018
3 Reads

Fetal stroke and cerebrovascular disease: Advances in understanding from lenticulostriate and venous imaging, alloimmune thrombocytopaenia and monochorionic twins.

Eur J Paediatr Neurol 2018 Nov 11;22(6):989-1005. Epub 2018 Sep 11.

Departments of Child Health, Obstetrics and Gynaecology and Radiology, University Hospital Southampton, United Kingdom; Clinical and Experimental Sciences, University of Southampton, United Kingdom.

Fetal stroke is an important cause of cerebral palsy but is difficult to diagnose unless imaging is undertaken in pregnancies at risk because of known maternal or fetal disorders. Fetal ultrasound or magnetic resonance imaging may show haemorrhage or ischaemic lesions including multicystic encephalomalacia and focal porencephaly. Serial imaging has shown the development of malformations including schizencephaly and polymicrogyra after ischaemic and haemorrhagic stroke. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.08.008DOI Listing
November 2018
11 Reads

A Review of Outcomes in Pregnant Women with Portal Hypertension.

J Obstet Gynaecol India 2018 Dec 5;68(6):447-451. Epub 2017 Jun 5.

Department of Obstetric Medicine, Fernandez Hospital, Unit 2, 3-6-282, opp: Old MLA Quarters, Hyderguda, Hyderabad, Telangana 500029 India.

Background: The course of pregnancy in a woman with portal hypertension is a difficult one as it is associated with complications like variceal bleeding, splenic artery rupture and coagulopathy. All these pose a threat to a woman's life. Although this condition is rare, every obstetrician should have a high index of suspicion when an antenatal mother presents with splenomegaly, thrombocytopenia or hematemesis. Read More

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http://link.springer.com/10.1007/s13224-017-1016-1
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http://dx.doi.org/10.1007/s13224-017-1016-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207547PMC
December 2018
10 Reads

CARE-Placental site trophoblastic tumor presenting with thrombotic microangiopathy: A case report.

Medicine (Baltimore) 2018 Oct;97(43):e12698

Department of Gynaecology.

Rationale: Placental site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasm (GTN).

Patient Concerns: A 28-year-old Chinese female with initial presentation of thrombotic microangiopathy (TMA) with symptoms of edema of the lower extremities and eyelid, thrombocytopenia and anemia.

Diagnoses: The primary diagnosis was chronic glomerulonephritis according to the related laboratory tests and clinical symptoms. Read More

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http://dx.doi.org/10.1097/MD.0000000000012698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221699PMC
October 2018
2 Reads

Zonal cortical scarring and tubular thyroidization in kidney biopsies of patients with SLE-histologic indicator for antiphospholipid antibodies.

Lupus 2018 Dec 7;27(14):2236-2244. Epub 2018 Nov 7.

2 Department of Pathology, Division of Renal and Transplant Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Antiphospholipid antibody syndrome (APS) is an acquired prothrombotic autoimmune disease caused by the presence of antibodies against anionic phospholipids or plasma proteins bound to phospholipids on cell membranes. It can be a primary disease or secondary to other autoimmune diseases, most commonly systemic lupus erythematosus (SLE). Laboratory testing for antiphospholipid antibodies (aPL) may be only transiently positive, so APS could be missed until a catastrophic thrombotic episode or pregnancy morbidity occurs. Read More

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http://dx.doi.org/10.1177/0961203318809177DOI Listing
December 2018
8 Reads

Pathogenesis of Atypical Hemolytic Uremic Syndrome.

J Atheroscler Thromb 2019 Feb 2;26(2):99-110. Epub 2018 Nov 2.

Division of Nephrology and Endocrinology, the University of Tokyo Hospital.

Atypical hemolytic uremic syndrome (aHUS) is a type of thrombotic microangiopathy (TMA) defined by thrombocytopenia, microangiopathic hemolytic anemia, and renal failure. aHUS is caused by uncontrolled complement activation in the alternative pathway (AP). A variety of genetic defects in complement-related factors or acquired autoantibodies to the complement regulators have been found in 50 to 60% of all cases. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_RV1
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http://dx.doi.org/10.5551/jat.RV17026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365154PMC
February 2019
10 Reads

The role of α2-adrenergic receptors in hypertensive preeclampsia: A hypothesis.

Microcirculation 2019 Jan 27;26(1):e12511. Epub 2018 Nov 27.

Department of Pharmacology and Toxicology, American University of Beirut, Beirut, Lebanon.

Preeclampsia, a major disorder of human pregnancy, manifests as persistent hypertension and proteinuria presenting after 20 weeks of pregnancy. Multiple systemic symptoms might be associated with preeclampsia including thrombocytopenia, liver impairment, pulmonary edema, and cerebral disturbances. However, vascular dysfunction remains the core pathological driver of preeclampsia. Read More

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http://doi.wiley.com/10.1111/micc.12511
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http://dx.doi.org/10.1111/micc.12511DOI Listing
January 2019
7 Reads

Reproductive and developmental toxicity study of caffeic acid in mice.

Food Chem Toxicol 2019 Jan 23;123:106-112. Epub 2018 Oct 23.

Department of Hematology, Qilu Hospital, Shandong University, Jinan, China; Shandong Provincial Key Laboratory of Immunohematology, Qilu Hospital, Shandong University, Jinan, China; Leading Research Group of Scientific Innovation, Department of Science and Technology of Shandong Province, Qilu Hospital, Shandong University, Jinan, China. Electronic address:

Caffeic acid is an antioxidant commonly used to promote hematopoiesis and hemostasis. However, little is known about its systemic safety profile in reproduction and development. Here, we focused on the reproductive and developmental toxicity of caffeic acid in F0 female mice and F1 offspring. Read More

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http://dx.doi.org/10.1016/j.fct.2018.10.040DOI Listing
January 2019
4 Reads

Postpartum Methicillin-Resistant Toxic Shock Syndrome Caused by a Perineal Infection.

Case Rep Obstet Gynecol 2018 30;2018:2670179. Epub 2018 Sep 30.

Department of Obstetrics and Gynecology, Hashimoto Municipal Hospital, Wakayama, Japan.

Although toxic shock syndrome (TSS) is rare, multiorgan failure can occur without early identification and appropriate therapy. In particular, a few cases of postpartum TSS due to methicillin-resistant (MRSA) have been reported. Here, we describe a rare case in which a 32-year-old Japanese woman had TSS due to MRSA that was caused by a perineal infection after a normal vaginal delivery. Read More

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https://www.hindawi.com/journals/criog/2018/2670179/
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http://dx.doi.org/10.1155/2018/2670179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186360PMC
September 2018
12 Reads

Shiga Toxin-Producing Infections during Pregnancy.

Microorganisms 2018 Oct 23;6(4). Epub 2018 Oct 23.

Laboratorio de Fisiopatogenia, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO Houssay-CONICET), Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires 1121, Argentina.

Gastrointestinal infection with Shiga toxin-producing (STEC) causes diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS), characterized by hemolytic anemia, thrombocytopenia and acute renal failure. The main virulence factor of STEC is Shiga toxin (Stx), which is responsible for HUS development. STEC can produce Stx type 1 and/or 2 (Stx1, Stx2) and their variants, Stx2 being more frequently associated with severe cases of HUS. Read More

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http://www.mdpi.com/2076-2607/6/4/111
Publisher Site
http://dx.doi.org/10.3390/microorganisms6040111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313425PMC
October 2018
18 Reads

Clinical characteristics, neonatal risk and recurrence rate of gestational thrombocytopenia with platelet count <100 × 10/L.

Eur J Obstet Gynecol Reprod Biol 2018 Dec 10;231:75-79. Epub 2018 Oct 10.

Hematology Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address:

Objective: Gestational thrombocytopenia (GT) accounts for 75% of cases of thrombocytopenia in pregnancy. In most cases of GT, thrombocytopenia is mild (100-150 × 10/L) and has no consequences for either the mother or the fetus. We aimed to investigate the characteristics, neonatal risk and recurrence rate of GT with a platelet count <100 × 10/L. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.10.026DOI Listing
December 2018
13 Reads

Validation of the PLASMIC score, a clinical prediction tool for thrombotic thrombocytopenic purpura diagnosis, in Chinese patients.

Thromb Res 2018 12 12;172:9-13. Epub 2018 Oct 12.

Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address:

Background: The recently published PLASMIC score was shown to be an excellent diagnostic model to identify patients with severe ADAMTS-13 deficiency. However, it is unclear if this score is suitable for Chinese patients with suspected thrombotic thrombocytopenic purpura (TTP).

Methods: We retrospectively studied a Chinese cohort of 134 consecutively hospitalized patients with thrombotic microangiopathy, ADAMTS-13 test results, and clinical information between January 2015 and June 2018, the PLASMIC score's distinguishing ability in this cohort was evaluated. Read More

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http://dx.doi.org/10.1016/j.thromres.2018.10.010DOI Listing
December 2018
2 Reads

Platelet Counts during Pregnancy.

Authors:
Philip Rubin

N Engl J Med 2018 10;379(16):1581

Maimonides Medical Center, Brooklyn, NY

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http://dx.doi.org/10.1056/NEJMc1810467DOI Listing
October 2018
2 Reads

Non Catether Induced Renal and Inferior Vena Cava Trombosis in a Neonate: A Case Report.

Open Access Maced J Med Sci 2018 Sep 23;6(9):1678-1681. Epub 2018 Aug 23.

Nephrology Department, University Children Hospital, Skopje, Republic of Macedonia.

Background: Neonatal renal vein thrombosis is the most common vascular condition in the newborn kidney, which could lead to serious complication in infants.

Case Report: We report a case of the unilateral renal vein and inferior vena cava thrombosis, presented with gross hematuria and thrombocytopenia in a neonate. The neonate was a macrosomic male born to a mother with hyperglycemia in pregnancy. Read More

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http://dx.doi.org/10.3889/oamjms.2018.306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182507PMC
September 2018
3 Reads

Platelet Counts during Pregnancy.

N Engl J Med 2018 10;379(16):1581-1582

University of Oklahoma Health Sciences Center, Oklahoma City, OK

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http://dx.doi.org/10.1056/NEJMc1810467DOI Listing
October 2018
4 Reads

Implication of antibodies against human leukocyte antigen in simultaneous presentation of fetal and neonatal alloimmune thrombocytopenia and neutropenia.

Transfus Apher Sci 2018 Dec 29;57(6):773-776. Epub 2018 Sep 29.

Division of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA, United States.

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) and neonatal alloimmune neutropenia (NAN) are two rare complications of newborns caused by antibodies against paternal inherited antigens. Human platelet (HPA) and neutrophil antigens (HNA) are the common targets. Human leukocyte antigen (HLA) class I proteins are also expressed on platelets and neutrophils and anti-HLA antibodies have occasionally been implicated in these complications. Read More

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http://dx.doi.org/10.1016/j.transci.2018.09.018DOI Listing
December 2018
4 Reads

ADAMTS13 Gene Mutations Influence ADAMTS13 Conformation and Disease Age-Onset in the French Cohort of Upshaw-Schulman Syndrome.

Thromb Haemost 2018 Nov 12;118(11):1902-1917. Epub 2018 Oct 12.

Institut Universitaire d'Hématologie, Université Paris Diderot, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.

Background:  Congenital thrombotic thrombocytopaenic purpura (TTP) or Upshaw-Schulman syndrome (USS) is a rare, life-threatening, inherited thrombotic microangiopathy (TMA). USS is mostly due to bi-allelic recessive sequence variations of the () gene inducing a severe ADAMTS13 deficiency (activity < 10 IU/dL). In healthy individuals, ADAMTS13 circulates in a folded conformation where CUB domains interact with the spacer domain. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1673686
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http://dx.doi.org/10.1055/s-0038-1673686DOI Listing
November 2018
3 Reads

Atypical Hemolytic-Uremic Syndrome: An Update on Pathophysiology, Diagnosis, and Treatment.

Ther Apher Dial 2019 Feb 29;23(1):4-21. Epub 2018 Oct 29.

Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

Atypical hemolytic uremic syndrome (aHUS), a rare variant of thrombotic microangiopathy, is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal impairment. The condition is associated with poor clinical outcomes with high morbidity and mortality. Atypical HUS predominantly affects the kidneys but has the potential to cause multi-organ system dysfunction. Read More

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http://dx.doi.org/10.1111/1744-9987.12763DOI Listing
February 2019
18 Reads

Anemia and other hematological profiles of pregnant women attending antenatal care in Debre Berhan Referral Hospital, North Shoa, Ethiopia.

BMC Res Notes 2018 Oct 5;11(1):704. Epub 2018 Oct 5.

Pharmacy Department, College of Health Sciences, Debre Markos University, P. O. Box, 269, Debre Markos, Ethiopia.

Objective: The aim of the study was to determine level of anemia and other hematological profiles in pregnant women attending antenatal care clinic in Debre Berhan Referral Hospital, Ethiopia.

Results: Prevalence of anemia was 2.8% and that of thrombocytopenia was 10. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-018-3805-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173918PMC
October 2018
4 Reads

Eculizumab in a pregnant patient with laboratory onset of catastrophic antiphospholipid syndrome: A case report.

Medicine (Baltimore) 2018 Oct;97(40):e12584

Department of Obstetrics and Gynecology, IRCCS Ospedale San Raffaele, Milan, Italy.

Rationale: Hypercoagulability and pregnancy morbidity are hallmarks of the antiphospholipid syndrome (APS). Catastrophic antiphospholipid syndrome (CAPS) is a potentially life-threatening omplication of APS, with widespread acute thrombotic microangiopathy (TMA) that can be precipitated by pregnancy and delivery and result in multiorgan damage. Unrestrained activation of the complement cascade is involved, favoring endothelial activation, tissue factor expression by leukocytes, and platelet aggregation. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810050-0003
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http://dx.doi.org/10.1097/MD.0000000000012584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200483PMC
October 2018
5 Reads

Management of antiphospholipid syndrome.

Ann Rheum Dis 2019 Feb 3;78(2):155-161. Epub 2018 Oct 3.

Department of Rheumatology, Dubai Hospital, Dubai, United Arab Emirates

Antiphospholipid syndrome, also known as 'Hughes Syndrome', is an autoimmune disease characterised by a set of clinical manifestations, almost all of which are direct or indirect sequelae of a hypercoagulable state involving the venous, and to a lesser extent the arterial vasculature. The incidence and prevalence of antiphospholipid syndrome are estimated at approximately 5 de novo cases per 100 000 per year and 40-50 cases per 100 000 individuals, respectively. The clinical spectrum of antiphospholipid syndrome involves haematological (thrombocytopaenia, venous thrombosis), obstetrical (recurrent pregnancy loss), neurological (stroke, transient ischaemic attack, migraine, seizures, cognitive dysfunction, chorea, transverse myelitis, multiple sclerosis), cardiovascular (cardiac valve disease), dermatological (livedo reticularis and racemosa, skin ulceration and necrosis), renal (glomerulonephritis, renal thrombotic microangiopathy) and orthopaedic (avascular necrosis of bones, non-traumatic fractures) manifestations, among others. Read More

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21384
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http://dx.doi.org/10.1136/annrheumdis-2018-213846DOI Listing
February 2019
5 Reads

Thrombotic Microangiopathies with Rheumatologic Involvement.

Rheum Dis Clin North Am 2018 11 7;44(4):635-649. Epub 2018 Sep 7.

Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University, 2150 Pennsylvania Avenue, Washington, DC 20037, USA. Electronic address:

Thrombotic microangiopathies are heterogeneous disorders characterized by microangiopathic hemolytic anemia with thrombocytopenia and renal injury. There are a variety of causes, including metabolic disorders, infections, medications, complement disorders, pregnancy, malignancy, and autoimmune disorders. This review focuses on renal thrombotic microangiopathy in the setting of rheumatologic diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0889857X183006
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http://dx.doi.org/10.1016/j.rdc.2018.06.010DOI Listing
November 2018
31 Reads

Transient EDTA-Dependent Pseudothrombocytopenia Phenomenon in a Patient with Antiphospholipid Syndrome.

Clin Lab 2018 Sep;64(9):1581-1583

Antiphospholipid syndrome (APS) is an autoimmune disorder associated with arterial/venous thrombosis and pregnancy loss; thrombocytopenia is another common manifestation of APS. In the present study, we discovered a transient ethylenediaminetetraacetic acid-dependent pseudothrombocytopenia (EDTA-PTCP) phenomenon in APS, which has not yet been reported in the literature. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180337DOI Listing
September 2018
8 Reads

Need for guidelines for the combined management of pregnancy and dengue: a retrospective study from an Indian tertiary care maternity hospital.

Trop Doct 2018 Sep 30:49475518800638. Epub 2018 Sep 30.

Consultant obstetrician, Department of Obstetrics, Fernandez Hospital, Telangana, Hyderabad, India.

The incidence of dengue has risen in India in recent years. Evidence suggests that dengue in pregnancy may be associated with adverse maternal and fetal outcomes. The aim of our study was to analyse outcomes in pregnant women with confirmed dengue infection who had the benefit of close monitoring and intensive management at a tertiary maternity facility. Read More

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http://dx.doi.org/10.1177/0049475518800638DOI Listing
September 2018
8 Reads

Adverse effects of antiretroviral therapy in pregnant women infected with HIV in Brazil from 2000 to 2015: a cohort study.

BMC Infect Dis 2018 Sep 27;18(1):485. Epub 2018 Sep 27.

Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Campinas, Brazil.

Background: Antiretroviral therapy (ART) use in pregnancy presents unquestionable benefits in preventing mother-to-child transmission (MTCT) of HIV although it is associated with maternal adverse effects. The aim of this study was to evaluate the adverse effects of antiretroviral therapy in pregnant women infected with HIV.

Methods: Cohort study of pregnant women infected with HIV followed at the CAISM/UNICAMP Obstetric Clinic from 2000 to 2015. Read More

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http://dx.doi.org/10.1186/s12879-018-3397-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161436PMC
September 2018
11 Reads

Fetal and Maternal Outcomes of Planned Pregnancy in Patients with Systemic Lupus Erythematosus: A Retrospective Multicenter Study.

J Immunol Res 2018 3;2018:2413637. Epub 2018 Sep 3.

Department of Rheumatology, The First Affiliated Hospital of Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou 510080, China.

Objective: To investigate the fetal and maternal outcomes as well as predictors of APOs in women with SLE who conceived when the disease was stable, the so-called "planned pregnancy." . A retrospective multicenter study of 243 patients with SLE who underwent a planned pregnancy was performed. Read More

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http://dx.doi.org/10.1155/2018/2413637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140277PMC
December 2018
9 Reads

Noninvasive prenatal diagnosis by cell-free DNA screening for fetomaternal HPA-1a platelet incompatibility.

Transfusion 2018 Oct 17;58(10):2272-2279. Epub 2018 Sep 17.

Instituto de Investigaciones Biomédicas de Sevilla, IBIS (Universidad de Sevilla, HUVR, Junta de Andalucía, CSIC), Hospital Universitario Virgen del Rocío-Universidad de Sevilla, Seville, Andalucía, Spain.

Background: The development of new noninvasive approaches for the diagnosis of human platelet antigen (HPA)-1 fetomaternal incompatibility has become of great interest. These approaches allow determination of whether the fetus is incompatible or not with the mother and a decision on antenatal therapy to avoid fetal or neonatal alloimmune thrombocytopenia (FNAIT). The objective of this work was to perform rapid, noninvasive prenatal test for HPA-1ab fetal antigen detection after the detection of an HPA-1-homozygous mother by using plasma cell-free DNA (cfDNA). Read More

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http://doi.wiley.com/10.1111/trf.14837
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http://dx.doi.org/10.1111/trf.14837DOI Listing
October 2018
11 Reads

From thrombasthenia to next generation thrombocytopenia: Neonatal alloimmune thrombocytopenia induced by maternal Glanzmann thrombasthenia.

Pediatr Blood Cancer 2018 Dec 14;65(12):e27376. Epub 2018 Sep 14.

National Hemophilia Center and Thrombosis Institute, Sheba Medical Center, Tel Hashomer, Israel.

Background: Glanzmann thrombasthenia (GT) is a rare autosomal recessive disorder of platelet function caused by mutations in the genes coding for integrin αIIbβ3. The aim of this study was to examine the outcome of newborns of GT mothers, with emphasis on thrombocytopenia and bleeding manifestations and their relation to maternal antiplatelet antibodies.

Procedure: Medical files of all female patients with GT treated in a single tertiary center from 1999 to 2017 were searched for details on pregnancy and birth. Read More

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http://doi.wiley.com/10.1002/pbc.27376
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http://dx.doi.org/10.1002/pbc.27376DOI Listing
December 2018
7 Reads

Placenta percreta complicated by uterine rupture and thrombotic microangiopathy.

Acta Med Litu 2018 ;25(2):61-65

Department of Obstetrics and Gynaecology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.

Background: Uterine rupture at the site of a previous caesarean scar with abnormal placental penetration through the uterus wall with bladder invasion is a rare and serious pregnancy complication. Our aim was to report a case of uterine rupture with placenta percreta complicated by thrombotic microangiopathy.

Materials And Methods: We did a literature review and analysed medical documentation retrospectively. Read More

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http://dx.doi.org/10.6001/actamedica.v25i2.3758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130928PMC
January 2018
3 Reads

Risk factors associated with neonatal thrombocytopenia in pregnant women with immune thrombocytopenic purpura.

J Matern Fetal Neonatal Med 2018 Nov 4:1-7. Epub 2018 Nov 4.

b Hematology Department , Hadassah, Hebrew University Medical Center , Jerusalem , Israel.

Objectives: To characterize the risk factors associated with neonatal thrombocytopenia among pregnant women with immune thrombocytopenic purpura (ITP).

Methods: We reviewed the records of ITP patients who delivered during 2006-2016 at our medical center.

Results: Of 253 pregnancies, median maternal age at diagnosis was 29 [25-33] years, 222 (87. Read More

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http://dx.doi.org/10.1080/14767058.2018.1523891DOI Listing
November 2018
3 Reads