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Long-term Visual Outcomes and Causes of Vision Loss in Chronic Central Serous Chorioretinopathy.

Ophthalmology 2019 Jan 16. Epub 2019 Jan 16.

Vitreous, Retina, Macula Consultants of New York, NY, USA; LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, NY, USA; Department of Ophthalmology, New York University School of Medicine, New York, NY, USA.

Purpose: To evaluate the long-term visual outcomes and causes of vision loss in chronic central serous chorioretinopathy (CSC).

Design: Retrospective, longitudinal study SUBJECTS: One-hundred and thirty-three subjects (217 eyes) with chronic CSC.

Methods: A retrospective review of clinical and multimodal imaging data of patients with chronic CSC managed by 3 of the authors between May 1977 and March 2018. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01616420173206
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http://dx.doi.org/10.1016/j.ophtha.2018.12.048DOI Listing
January 2019
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A drug utilization study to evaluate effectiveness of risk minimization measures for trimetazidine in France, Hungary, Romania and Spain.

J Clin Pharm Ther 2019 Jan 18. Epub 2019 Jan 18.

Drug Safety and Risk Management, Lupin Limited, Mumbai, India.

What Is Known And Objective: The approved indication for trimetazidine (TMZ) was restricted to "add-on therapy for the symptomatic treatment of patients with stable angina pectoris who are inadequately controlled by or intolerant to first-line antianginal therapies" in 2012 by the Committee for Medicinal Products for Human Use (CHMP). TMZ was no longer indicated for ophthalmology and otolaryngology (ENT) indications. This drug utilization study analysed actual utilization of TMZ before and after the restriction on its indications to evaluate the effectiveness of risk minimization measures (RMM). Read More

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http://dx.doi.org/10.1111/jcpt.12799DOI Listing
January 2019

Cold type autoimmune hemolytic anemia- a rare manifestation of infectious mononucleosis; serum ferritin as an important biomarker.

BMC Infect Dis 2019 Jan 18;19(1):68. Epub 2019 Jan 18.

Sri Jayawardanapura General Hospital, Thalapathpitiya, Nugegoda, Western province, Sri Lanka.

Background: Infectious mononucleosis is one of the main manifestations of Epstein - Barr virus, which is characterized by fever, tonsillar-pharyngitis, lymphadenopathy and atypical lymphocytes. Although 60% of patients with IMN develop cold type antibodies, clinically significant hemolytic anemia with a high ferritin level is very rare and validity of serum ferritin as an important biomarker has not been used frequently.

Case Presentation: 18-year-old girl presented with fever, malaise and sore throat with asymptomatic anemia, generalized lymphadenopathy, splenomegaly and mild hepatitis. Read More

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http://dx.doi.org/10.1186/s12879-019-3722-zDOI Listing
January 2019
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Characterizing the molecular epidemiology of Staphylococcus aureus across and within fitness facility types.

BMC Infect Dis 2019 Jan 18;19(1):69. Epub 2019 Jan 18.

Department of Biostatistics, Environmental Health Sciences and Epidemiology, Kent State University, College of Public Health, Kent, OH, USA.

Background: Staphylococcus aureus is a common bacterium found in the nose and throat of healthy individuals, and presents risk factors for infection and death. We investigated environmental contamination of fitness facilities with S. aureus in order to determine molecular types and antibiotic susceptibility profiles of contaminates that may be transmitted to facility patrons. Read More

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http://dx.doi.org/10.1186/s12879-019-3699-7DOI Listing
January 2019
1 Read
2.613 Impact Factor

Adverse symptoms users attribute to e-cigarettes: Results from a national survey of US adults.

Drug Alcohol Depend 2019 Jan 11;196:9-13. Epub 2019 Jan 11.

Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.

Background: Little is known about the prevalence of adverse symptoms electronic cigarette (e-cigarette) users report experiencing.

Methods: Between August 2016 and May 2017, we conducted a nationally representative cross-sectional telephone survey of 4964 US adults age 18 and over. Respondents who reported ever trying e-cigarettes were asked whether they ever experienced six symptoms they thought were caused by e-cigarette use. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.11.030DOI Listing
January 2019

Granulomatosis with polyangiitis in Northeastern Brazil: study of 25 cases and review of the literature.

Adv Rheumatol 2018 Jun 28;58(1):10. Epub 2018 Jun 28.

Post-Graduate Program in Medical Sciences, University of Fortaleza (UNIFOR), Fonseca Lobo 560 apto. 1202, Aldeota, Fortaleza, Ceará, CEP 60175020, Brazil.

Background: Little has been published about the epidemiology of Granulomatosis with polyangiitis (GPA) in South America, especially in the intertropical zone, and no epidemiological data from Brazil are available. The purpose of the present study was to draw a clinical and demographic profile of GPA patients living in Northeastern Brazil based on laboratory, histological and imaging findings, and evaluate the frequency of organic involvement.

Methods: Clinical, epidemiological and treatment data of GPA patients were collected retrospectively and compared with the literature. Read More

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http://dx.doi.org/10.1186/s42358-018-0010-3DOI Listing

Sleep apnea: Do not forget to inspect the throat!

Clin Case Rep 2019 Jan 22;7(1):143-145. Epub 2018 Nov 22.

Rhinology-Olfactology Unit, Department of Otorhinolaryngology - Head and Neck Surgery University Hospital of Geneva Geneva Switzerland.

Obstructive sleep apnea syndrome (OSAS) is a widespread and underdiagnosed disease. Causes are mostly related to obesity and anatomy with oro-pharyngeal narrowing. Parapharyngeal tumors are rare but can easily be treated. Read More

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http://dx.doi.org/10.1002/ccr3.1927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333070PMC
January 2019

Unusual manifestation of disseminated herpes simplex virus type 2 infection associated with pharyngotonsilitis, esophagitis, and hemophagocytic lymphohisitocytosis without genital involvement.

BMC Infect Dis 2019 Jan 17;19(1):65. Epub 2019 Jan 17.

Division of Rheumatology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Hon-komagome, Tokyo, 1138677, Bunkyo-ku, Japan.

Background: Herpes simplex virus (HSV) has various presentations, depending on the patient's immune status, age, and the route of transmission. In adults, HSV type 1 is found predominantly in the oral area, and HSV type 2 (HSV-2) is commonly found in the genital area. HSV-2 infection without genital lesions is uncommon. Read More

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http://dx.doi.org/10.1186/s12879-019-3721-0DOI Listing
January 2019

A new species of the genus Eudorylaimus Andrássy, 1959 (Nematoda: (Dorylaimida: Qudsianematidae) associated with Picea crassifolia in China.

Zootaxa 2018 Dec 3;4526(4):576-588. Epub 2018 Dec 3.

Lab of Plant Nematology/Research Center of Nematodes of Plant Quarantine, Department of Plant Pathology/Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Agriculture, South China Agricultural University, Guangzhou, Guangdong, China Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, Guangdong 510160, China.

A new species, Eudorylaimus piceae n. sp., extracted from rhizosphere soil of Picea crassifolia from Inner Mongolia, China was identified. Read More

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https://biotaxa.org/Zootaxa/article/view/zootaxa.4526.4.9
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http://dx.doi.org/10.11646/zootaxa.4526.4.9DOI Listing
December 2018
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First records of Composetia, Eunereis and Nectoneanthes (Annelida: Nereididae) from Taiwan, with descriptions of two new species.

Authors:
Pan-Wen Hsueh

Zootaxa 2018 Dec 12;4531(2):211-224. Epub 2018 Dec 12.

Department of Life Sciences, National Chung Hsing University, 145 Xinda Road, Taichung, Taiwan 402, R.O.C..

Three species of nereidids collected from various ecological surveys conducted on coasts of west central and northeastern of Taiwan are studied. Each species represents a genus in the subfamily Nereidinae Blainville, 1818 not previously reported from Taiwan: Composetia Hartmann-Schröder, 1985, Eunereis Malmgren, 1865 and Nectoneanthes Sato, 2013. Composetia budaiensis n. Read More

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http://dx.doi.org/10.11646/zootaxa.4531.2.3DOI Listing
December 2018

Diagnosis and antibiotic treatment of group a streptococcal pharyngitis in children in a primary care setting: impact of point-of-care polymerase chain reaction.

BMC Pediatr 2019 Jan 16;19(1):24. Epub 2019 Jan 16.

Roche Molecular Systems, Pleasanton, CA, USA.

Background: To compare the sensitivity and specificity of the recommended 2-step rapid antigen detection test (RADT) with confirmatory culture vs the point-of-care (POC) polymerase chain reaction (PCR) Roche cobas® Liat® Strep A test for detection of group A Streptococcus (GAS) in pediatric patients with pharyngitis, and to investigate the impact of these tests on antibiotic use in a large pediatric clinic.

Methods: This prospective, open-label study was conducted at a single site during fall/winter 2016-2017. A total of 275 patients aged 3 to 18 years with symptoms of pharyngitis had a throat-swab specimen analyzed using RADT, POC PCR, and culture. Read More

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http://dx.doi.org/10.1186/s12887-019-1393-yDOI Listing
January 2019

Otologic Findings Based on no Complaints in a Pediatric Examination.

Int Arch Otorhinolaryngol 2019 Jan 25;23(1):36-40. Epub 2018 Jul 25.

Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.

 the otological evaluation is highly significant in those branches of medicine in which the general evaluation of the patient is conducted by general practitioners and pediatricians.  To investigate the otologic findings and their incidences in the sample, which consisted of patients who presented to the pediatric outpatient clinic with non-otologic complaints.  Patients, aged between 2 and 16 years, who had neither otorhinolaryngological complaints nor history of surgery by the otolaryngology (ear, nose and throat, ENT) department were included in the present study. Read More

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http://dx.doi.org/10.1055/s-0038-1667007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331296PMC
January 2019

Transnasal Esophagoscopy-Our Experience.

Int Arch Otorhinolaryngol 2019 Jan 11;23(1):7-11. Epub 2018 Oct 11.

Department of ENT, Lancaster Royal Infirmary, Lancaster, United Kingdom of Great Britain and Northern Ireland.

 Transnasal esophagoscopy (TNE) is a widely used tool both in the diagnosis and treatment of patients presenting complaints within the head and the neck. This is because this investigative adjunct examination provides the advantage of visualizing above the level of the cricopharyngeus muscle when compared to the more widely used esophagogastroduodenoscopy (EGD).  We have assessed if the implementation of TNE within a district general hospital (DGH) was feasible, and investigated if the resources of our patients could be better directed away from other investigations such as barium swallow and EGD in favor of this novel technique. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1661359
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http://dx.doi.org/10.1055/s-0038-1661359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331291PMC
January 2019
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A new species of the genus Microhyla Tschudi, 1838 (Amphibia: Anura: Microhylidae) from Tay Nguyen Plateau, Central Vietnam.

Zootaxa 2019 Jan 9;4543(4):549-580. Epub 2019 Jan 9.

Asian Turtle Program-Indo-Myanmar Conservation, R.1806, 18th F., CT1 Bac Ha C14 Building To Huu St., Dist. Nam Tu Liem, Ha Noi, Vietnam..

We describe a new species of Microhyla from Tram Lap forest, Gia Lai Province, Central Vietnam based on morphological, molecular, and acoustic data. The new species resembles M. butleri morphologically, but differs from all congeners by a combination of the following morphological attributes: (1) medium-sized adult snout-vent length 25. Read More

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http://dx.doi.org/10.11646/zootaxa.4543.4.4DOI Listing
January 2019

Antibiotic therapy for an ENT specialist.

Authors:
Piotr Albrecht

Otolaryngol Pol 2018 Sep;72(6):1-9

Klinika Gastroenterologii i Żywienia Dzieci, Warszawski Uniwersytet Medyczny, Warszawa, Polska.

The study dedicated mainly to general practitioners of ENTs discusses the principles of antibiotic therapy of the most common diseases that this specialty deals with, namely acute tonsillitis and throat inflammation, acute otitis media (AOM), and acute sinusitis. The most common errors in the antibiotic therapy of these diseases are also presented. The basic antibiotic in streptococcal pharyngitis is and remains oral penicillin administered for 10 days. Read More

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http://dx.doi.org/10.5604/01.3001.0012.4704DOI Listing
September 2018

Evaluation of instructions in patient information leaflets for the use of intranasal corticosteroid sprays: an observational study.

BMJ Open 2019 Jan 15;9(1):e026710. Epub 2019 Jan 15.

Department of Paediatrics, Medical Center Leeuwarden, Leeuwarden, Netherlands.

Objectives: In this study, we analysed patient information leaflets (PILs) of intranasal corticosteroid sprays (INCS) of different manufacturers in the UK to determine if instructions for the use of INCS are complete and uniform.

Setting: PILs of all INCS of all manufacturers, available for patients in the UK, were collected from the British National Formulary website and the Medicines and Healthcare products Regulatory Agency website. All instructions in these PILs were analysed. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026710DOI Listing
January 2019
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Mitochondrial neurogastrointestinal encephalopathy: a clinicopathological mimic of Crohn's disease.

BMC Gastroenterol 2019 Jan 15;19(1):11. Epub 2019 Jan 15.

Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK.

Background: Mitochondrial neurogastrointestinal encephalopathy (MNGIE), due to mutations in TYMP, often presents with gastrointestinal symptoms. Two sisters, initially managed for Crohn's disease based upon clinical, imaging and pathological findings, were later found to have MNGIE. The cases provide novel clinicopathological insight, for two further reasons: both sisters remain ambulant and in employment in their late 20s and 30s; diagnosis in one sister was made after a suspected azathioprine-precipitated acute illness. Read More

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http://dx.doi.org/10.1186/s12876-018-0925-5DOI Listing
January 2019
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Current treatment procedures for civilian gunshot wounds.

Rozhl Chir 2018 ;97(12):558-562

Introduction: This work provides an overview of the incidence of gunshot wounds during peace conditions in a civilian population and aims to assess the principles of their treatment.

Method: We evaluated a total of 104 patients with gunshot wounds with an average age of 38.7 years (range 1871). Read More

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January 2018
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Augmentation of curved tip of left-sided double-lumen tubes to reduce right bronchial misplacement: A randomized controlled trial.

PLoS One 2019 15;14(1):e0210711. Epub 2019 Jan 15.

Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background: During intubation with a blind technique, a left-sided double-lumen tube (DLT) can be misdirected into the right bronchus even though its curved tip of the bronchial lumen turns to the left. This right bronchial misplacement may be associated with the tip angle of DLTs. We thus performed a randomized trial to test the hypothesis that the DLT with an acute tip angle enters the right bronchus less frequently than the tube with an obtuse tip angle. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210711PLOS
January 2019
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[How to assess the need for new specialists?]

Lakartidningen 2019 Jan 11;116. Epub 2019 Jan 11.

Norra Alvsborgs lanssjukhus - ÖNH-kliniken Trollhattan, Sweden Norra Alvsborgs lanssjukhus - ÖNH-kliniken Trollhattan, Sweden.

Continuous monitoring of the need to educate specialists is important in the planning of health care resources. In this article, the authors present a questionnaire-based tool that is answered by the heads of Departments of ear, nose and throat (ENT) across Sweden every year. In Stockholm, the movement of patients from university to private ENT has dramatically decreased specialist training in ENT, and this can be seen by the employment survey instrument called »Tjänsteenkäten«. Read More

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January 2019

Revisiting age-related admission following tonsillectomy in the pediatric population.

Laryngoscope 2019 Jan 15. Epub 2019 Jan 15.

Pediatric Ear, Nose, and Throat Associates of Alabama, Children's Hospital of Alabama, Birmingham, Alabama, U.S.A.

Objectives/hypothesis: The objectives of this study were to examine patient outcomes using a 36-month age cutoff as a strict admission criterion following tonsillectomy, and review the safety and determine the plausibility of same-day discharge of children under 3 years old following tonsillectomy.

Study Design: Retrospective chart review.

Methods: A chart review of patients aged 24 to 42 months undergoing tonsillectomy over a 3-year period was conducted. Read More

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http://doi.wiley.com/10.1002/lary.27795
Publisher Site
http://dx.doi.org/10.1002/lary.27795DOI Listing
January 2019
3 Reads

Internal surface electric charge characterization of mesoporous silica.

Sci Rep 2019 Jan 15;9(1):137. Epub 2019 Jan 15.

Department of Mechanical Engineering, Izmir Institute of Technology, Izmir, 35430, Turkey.

Mesoporous silica is an emerging technology to solve problems of existing and to support projected revolutionary applications ranging from targeted drug delivery to artificial kidney. However, one of the major driving mechanisms, electric charging of internal mesoporous surfaces, has not been characterized yet. In the nanoscale confinements of mesoporous structures made of pore throats and pore voids, surface charges diverge from existing theoretical calculations and show local variation due to two occurrences. Read More

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http://dx.doi.org/10.1038/s41598-018-36487-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333811PMC
January 2019

Endoscopic foregut surgery and interventions: The future is now. The state-of-the-art and my personal journey.

Authors:
Kenneth J Chang

World J Gastroenterol 2019 Jan;25(1):1-41

H.H. Chao Comprehensive Digestive Disease Center, University of California, Irvine Medical Center, Orange, CA 92868, United States.

In this paper, I reviewed the emerging field of endoscopic surgery and present data supporting the contention that endoscopy can now be used to treat many foregut diseases that have been traditionally treated surgically. Within each topic, the content will progress as follows: "lessons learned", "technical considerations" and "future opportunities". Lessons learned will provide a brief background and update on the most current literature. Read More

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https://www.wjgnet.com/1007-9327/full/v25/i1/1.htm
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http://dx.doi.org/10.3748/wjg.v25.i1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328959PMC
January 2019
1 Read

Foiling the barium swallow!

BMJ Case Rep 2019 Jan 14;12(1). Epub 2019 Jan 14.

ENT, Royal Victoria Hospital, Belfast, UK.

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http://dx.doi.org/10.1136/bcr-2018-228083DOI Listing
January 2019

Pain-free survival after vagoglossopharyngeal complex sectioning with or without microvascular decompression in glossopharyngeal neuralgia.

J Neurosurg 2019 Jan 11:1-7. Epub 2019 Jan 11.

OBJECTIVEGlossopharyngeal neuralgia (GN) is a rare pain condition in which patients experience paroxysmal, lancinating throat pain. Multiple surgical approaches have been used to treat this condition, including microvascular decompression (MVD), and sectioning of cranial nerve (CN) IX and the upper rootlets of CN X, or a combination of the two. The aim of this study was to examine the long-term quality of life and pain-free survival after MVD and sectioning of the CN X/IX complex. Read More

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http://dx.doi.org/10.3171/2018.8.JNS18239DOI Listing
January 2019
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Epidemiology and incidence of severe respiratory critical events in ear, nose and throat surgery in children in Europe: A prospective multicentre observational study.

Eur J Anaesthesiol 2019 Jan 10. Epub 2019 Jan 10.

From the Bolyai Institute, University of Szeged, Szeged, Hungary (KV), Département d'Anesthésie-Réanimation, Hôpital Armand Trousseau, Hôpitaux Universitaires Paris Est, Assistance Publique Hôpitaux de Paris, Paris, France (NS), Department of Anaesthesia, Great Ormond Street Hospital, London, UK (MT), Département d'Anesthésie-Réanimation pédiatrique, Hôpital Jeanne de Flandre, CHRU de Lille, Lille, France (FV) and Department of Anaesthesia, Pharmacology and Intensive Care, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland (WH).

Background: Ear, nose and throat (ENT) surgery, the most frequently performed surgical procedure in children, is a strong predictor for peri-operative respiratory complications. However, there is no clear information about peri-operative respiratory severe critical events (SCEs) associated with anaesthesia management of ENT children in Europe.

Objective: To characterise the epidemiology and incidence of respiratory SCEs during and following ENT surgery in Europe and to identify the risk factors for their occurrence. Read More

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http://dx.doi.org/10.1097/EJA.0000000000000951DOI Listing
January 2019
1 Read

Use of Commercial Direct-to-Consumer Telemedicine by Children.

Acad Pediatr 2019 Jan 10. Epub 2019 Jan 10.

Department of Health Care Policy, Harvard Medical School, Boston, MA; RAND Corporation, Boston, MA.

Objective: In commercial direct-to-consumer (DTC) telemedicine, physicians outside of the medical home treat common, acute complaints through real-time, audio-visual conferencing using telephones and personal computers. There has been little examination of the use of DTC telemedicine by children. We described trends in DTC telemedicine use and DTC telemedicine visit characteristics. Read More

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http://dx.doi.org/10.1016/j.acap.2018.11.016DOI Listing
January 2019

The Associations of Fruit and Vegetable Intakes with Burden of Diseases: A Systematic Review of Meta-Analyses.

J Acad Nutr Diet 2019 Jan 10. Epub 2019 Jan 10.

Background: Low fruit and vegetable intakes are recognized risk factors for noncommunicable diseases. This systematic review summarizes published meta-analyses of global burden of diseases attributable to low fruit and vegetable intakes, and the best relative risk estimates.

Methods: A published novel assessment process combining Cochrane Review measures, Assessing the Methodological Quality of Systematic Reviews checklist, and Newcastle-Ottawa Quality Assessment Scale was employed. Read More

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http://dx.doi.org/10.1016/j.jand.2018.11.007DOI Listing
January 2019
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Reducing ear, nose and throat (ENT) waitlists: Implications of a referral audit.

Health Policy 2018 Dec 31. Epub 2018 Dec 31.

Medical Services, Torres and Cape York Hospital and Health Service, Australia; Institute of Health Innovation, Macquarie University, Australia.

Introduction: Many specialist waitlists in Australian hospitals are long. One reason anecdotally reported for this is poor alignment of referrals with current recommended guidelines. This paper reports the findings of an audit undertaken in 2017 for ear, nose and throat (ENT) surgeon referrals submitted by primary health centres within Cape York, Australia. Read More

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http://dx.doi.org/10.1016/j.healthpol.2018.12.007DOI Listing
December 2018

Nebulizer Use in Adults With Subglottic Stenosis: A Survey Study.

Ann Otol Rhinol Laryngol 2019 Jan 14:3489418823797. Epub 2019 Jan 14.

2 Division of Otolaryngology-Head & Neck Surgery, The University of Utah, Salt Lake City, Utah, USA.

Objective:: People with subglottic stenosis (SGS) may experience laryngeal symptoms that pose significant challenges to management. This study surveyed the use and effects of nebulized treatments on laryngeal symptoms in a large cohort of adults with SGS.

Methods:: A survey of nebulized treatment practices was distributed to an online international community of over 2000 members; 316 individuals (298 female, 1 male, 17 declined to specify; age 25+ years) completed the survey. Read More

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http://dx.doi.org/10.1177/0003489418823797DOI Listing
January 2019
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Viral pathogens associated with acute lower respiratory tract infections in children younger than 5 years of age in Bulgaria.

Braz J Microbiol 2018 Dec 5. Epub 2018 Dec 5.

Medical University, University Hospital Alexandrovska, Pediatric Clinic, 1 St. Georgi Sofiiski, 1431, Sofia, Bulgaria.

Acute lower respiratory infections (ALRIs) are a leading cause of morbidity and hospital admissions in children. This study aimed to determine the viral etiology of these infections in children aged < 5 years during three successive epidemic seasons in Bulgaria. Nasopharyngeal and throat specimens were collected from children with bronchiolitis and pneumonia during the 2015/2016, 2016/2017, and 2017/2018 seasons. Read More

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http://dx.doi.org/10.1007/s42770-018-0033-2DOI Listing
December 2018
1 Read

The Association of 3-D Volume and 2-D Area of Post-swallow Pharyngeal Residue on CT Imaging.

Dysphagia 2019 Jan 14. Epub 2019 Jan 14.

Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.

Pharyngeal residue, the material that remains in the pharynx after swallowing, is an important marker of impairments in swallowing and prandial aspiration risk. The goals of this study were to determine whether the 2D area of post-swallow residue accurately represents its 3D volume, and if the laterality of residue would affect this association. Thirteen patients with dysphagia due to brainstem stroke completed dynamic 320-detector row computed tomography while swallowing a trial of 10 ml honey-thick barium. Read More

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http://dx.doi.org/10.1007/s00455-018-09968-3DOI Listing
January 2019
1 Read

Staphylococcus aureus Colonization in Patients Undergoing Total Hip or Knee Arthroplasty and Cost-effectiveness of Decolonization Programme.

Arch Bone Jt Surg 2018 Nov;6(6):554-559

Research performed at Bone and Joint Reconstruction Center, Vali-Asr Hospital, Arak University of Medical Sciences, Arak, Iran.

Background: Periprosthetic joint infection is a devastating complication of total joint arthroplasty. It seems that the patient's skin, nose, throat, and urine are important sites for microbial colonization. Colonization with staphylococcus aureus, especially methicillin resistant increases the risk of periprosthetic joint infection. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310181PMC
November 2018

Qualitative analysis of the experiences of gay, bisexual and other men who have sex with men who use : a comprehensive internet-based diagnostic service for HIV and other STIs.

Sex Transm Infect 2019 Jan 13. Epub 2019 Jan 13.

School of Population and Public Health, University of British Columbia, Vancouver, Canada.

Objectives: To describe the factors that influence gay, bisexual and other men who have sex with men's (gbMSM) experiences with (GCO) in British Columbia (BC), Canada. GCO clients complete an internet-based risk assessment and print a laboratory test requisition form for HIV and other STIs to take to a private laboratory for diagnostic services.

Methods: Drawing on a purposive stratified sampling framework, we conducted 37 in-depth semistructured interviews with gbMSM who had used GCO at least once between 2015 and 2017. Read More

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http://dx.doi.org/10.1136/sextrans-2018-053645DOI Listing
January 2019

Clinical Characteristics and Antibiotic Resistance of Mycoplasma Pneumoniae Pneumonia in Hospitalized Chinese Children.

Comb Chem High Throughput Screen 2019 Jan 10. Epub 2019 Jan 10.

Department of Respiration, The First Hospital of Huzhou, First Affiliated Hospital of Huzhou University, No. 158 Guangchanghou Road, Huzhou, Zhejiang, 313000. China.

Aim To analyze the clinical characteristics and antibiotic resistance of Mycoplasma pneumoniae pneumonia (MP) in Chinese patients, providing valuable information for the management of patients with MP. Methods A total of 120 children who were hospitalized in The First Hospital of Huzhou between January and December 2016 for respiratory tract infection due to M. pneumoniae were enrolled in this study. Read More

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http://dx.doi.org/10.2174/1386207322666190111112946DOI Listing
January 2019
2 Reads

Clinico-epidemiological profile and predictors of outcome in children with diphtheria: a study from northern India.

Trop Doct 2019 Jan 12:49475518823657. Epub 2019 Jan 12.

3 Professor, Department of Pediatrics (Emergency and Critical Care), PGIMER, Chandigarh, India.

Diphtheria, a vaccine preventable disease in children, is still being reported from India. Details of 99 children with a clinical diagnosis of diphtheria admitted to a paediatric tertiary care teaching and referral hospital between January 2008 and December 2015 were collected retrospectively and analysed. The median (interquartile range [IQR]) age of the study group was 7. Read More

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http://dx.doi.org/10.1177/0049475518823657DOI Listing
January 2019
2 Reads
0.528 Impact Factor

Patterns of e-cigarette use, biochemically verified smoking status and self-reported changes in health status of a random sample of vapeshops customers in Greece.

Intern Emerg Med 2019 Jan 11. Epub 2019 Jan 11.

National School of Public Health, Alexandras Av. 196, 11521, Athens, Greece.

To understand the population impact of e-cigarettes, it is important to examine the profile of e-cigarette users. The purpose was to examine the characteristics, patterns of e-cigarette use and smoking status of a random sample of vapeshops customers in Greece. Fourteen vapeshops were randomly selected in the region of Athens. Read More

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http://dx.doi.org/10.1007/s11739-018-02011-1DOI Listing
January 2019

Is CT or MRI the optimal imaging investigation for the diagnosis of large vestibular aqueduct syndrome and large endolymphatic sac anomaly?

Eur Arch Otorhinolaryngol 2019 Jan 11. Epub 2019 Jan 11.

251 General and VA Air Force Hospital, Athens, Greece.

Background And Purpose: We explored whether there was a difference between measurements obtained with CT and MRI for the diagnosis of large vestibular aqueduct syndrome or large endolymphatic sac anomaly, and whether this influenced diagnosis on the basis of previously published threshold values (Valvassori and Cincinnati). We also investigated whether isolated dilated extra-osseous endolymphatic sac occurred on MRI. Secondary objectives were to compare inter-observer reproducibility for the measurements, and to investigate any mismatch between the diagnoses using the different criteria. Read More

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http://dx.doi.org/10.1007/s00405-019-05279-xDOI Listing
January 2019

CD73 expression on effector T cells sustained by TGF-β facilitates tumor resistance to anti-4-1BB/CD137 therapy.

Nat Commun 2019 Jan 11;10(1):150. Epub 2019 Jan 11.

Department of Medicine-Division of Hematology/Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.

Agonist antibodies (Ab) directed against costimulatory molecules on the surface of antigen-primed T cells are in various stages of pre-clinical and clinical trials, albeit with limited therapeutic benefit as single agents. The underlying mechanisms of action remain incompletely understood. Here, we demonstrate an inhibitory role of ecto-enzyme CD73 for agonistic anti-4-1BB/CD137 Ab therapy. Read More

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http://www.nature.com/articles/s41467-018-08123-8
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http://dx.doi.org/10.1038/s41467-018-08123-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329764PMC
January 2019
2 Reads
10.742 Impact Factor

Otoendoscopy aids diagnosis of a rare ear canal tumour.

BMJ Case Rep 2019 Jan 10;12(1). Epub 2019 Jan 10.

Ear, Nose and Throat Surgery, Northwick Park Hospital, Harrow, UK.

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http://dx.doi.org/10.1136/bcr-2018-228417DOI Listing
January 2019
1 Read

Should we be moving to a national standardized non-gadolinium MR imaging protocol for the surveillance of vestibular schwannomas?

Br J Radiol 2019 Jan 11:20180833. Epub 2019 Jan 11.

1 Department of Neuroradiology, Leeds Teaching Hospitals NHS Trust , Leeds , UK.

Objectives:: To examine whether the model of Getting It Right First Time (GIRFT) could be relevant to the surveillance of non-operated vestibular schwannomas (vs) by testing the following hypotheses: (1) in the UK there is a great variation in the imaging protocol for the follow-up of vs; (2) high-resolution, T weighted MRI (HRT W-MRI) has an equivalent accuracy to gadolinium-enhanced T weighted MRI (Gd-MRI) in the assessment of vs size and; (3) imaging with HRT W-MRI rather than Gd-MRI could offer financial savings.

Methods:: Two neuroradiologists independently performed measurements of 50 vs imaged with HRT W-MRI and Gd-MRI. Differences in mean tumour measurements between HRT W-MRI and Gd-MRI were determined, as were intra- and interobserver concordance. Read More

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http://dx.doi.org/10.1259/bjr.20180833DOI Listing
January 2019

Effect of dupilumab on atopic manifestations in patients treated for atopic dermatitis in real life practice.

Br J Dermatol 2019 Jan 11. Epub 2019 Jan 11.

Dermatology and Allergology Department, Larrey Hospital, Toulouse University.

Dupilumab has demonstrated efficacy in atopic dermatitis (AD) , asthma , perennial allergic rhinitis and chronic sinusitis . The objectives of this prospective observational, single-centre study were to assess 1) dupilumab efficacy in real-life practice and 2) the evolution of atopic co-morbidities and specific immunoglobulin E (IgE) levels during dupilumab treatment. This article is protected by copyright. Read More

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http://doi.wiley.com/10.1111/bjd.17629
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http://dx.doi.org/10.1111/bjd.17629DOI Listing
January 2019
5 Reads

Neural System and Receptor Diversity in the Ctenophore Beroe abyssicola.

J Comp Neurol 2019 Jan 11. Epub 2019 Jan 11.

Whitney Laboratory for Marine Biosciences, University of Florida, St. Augustine, FL, USA.

Although, neuro-sensory systems might have evolved independently in ctenophores, very little is known about their organization and functions. Most ctenophores are pelagic and deep-water species and cannot be bred in the laboratory. Thus, it is not surprising that neuroanatomical data are available for only one genus within the group - Pleurobrachia. Read More

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http://dx.doi.org/10.1002/cne.24633DOI Listing
January 2019

Determining effectiveness of EBM education in otolaryngology residents using modified fresno test.

Laryngoscope 2019 Jan 10. Epub 2019 Jan 10.

Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran, Iran.

Objective: To determine the effectiveness of education in evidence-based medicine (EBM) on the knowledge, competency, and skills of otolaryngology residents of Tehran University of Medical Sciences (TUMS) at Amir-Alam and Imam Khomeini Hospitals.

Methods: In a quasi-experimental (before-and-after) study, all ear, nose, and throat residents of TUMS (n = 41) entered the study. The residents underwent the modified Fresno test. Read More

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http://dx.doi.org/10.1002/lary.27762DOI Listing
January 2019
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Sore Throat, Fever, Septic Emboli, and Acute Respiratory Distress Syndrome: A Case of Lemierre Syndrome.

Case Rep Emerg Med 2018 6;2018:7373914. Epub 2018 Dec 6.

M.D., Department of Radiology, Montefiore Medical Center, Bronx, NY, USA.

Lemierre's syndrome is an acute oropharyngeal infection with a secondary septic thrombophlebitis of the internal jugular vein (IVJ) that was first reported in literature in 1936. It involves the progression of disease from a focal suppurative peritonsillar infection to a local septic thrombophlebitis with hematogenous progression to and distant septic emboli. It is a rare and potentially fatal syndrome requiring prompt diagnosis and management. Read More

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https://www.hindawi.com/journals/criem/2018/7373914/
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http://dx.doi.org/10.1155/2018/7373914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304635PMC
December 2018
2 Reads

Agenesis of Isthmus of Thyroid Gland in the Presence of Ectopic Thyroid Tissue Associated with Papillary Carcinoma.

J Coll Physicians Surg Pak 2019 Jan;29(1):75-77

Department of General Pathology4, University of Giresun, School of Medicine, Giresun, Turkey.

The thyroid is an endocrine gland composed of two lateral lobes connected by a strip of thyroid tissue called an isthmus. The thyroid gland is usually associated with extensive morphological variations and developmental anomalies. During the 4th intrauterine week, the thyroid gland begins to develop mainly from the invagination of the endodermal cells of the ventral floor of the primitive pharynx. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.01.75DOI Listing
January 2019
0.318 Impact Factor

Properties of Staphylococcus aureus strains from food processing staff.

Epidemiol Mikrobiol Imunol 2018 ;67(4):161-165

Aim: The food processing staff may act as a reservoir of virulent strains of Staphylococcus aureus and contribute to their transmission to foods. The aim of this study was to assess the occurrence and properties of S. aureus in cheese factory staff. Read More

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January 2018
1 Read

[Multicenter study of human adenovirus infection in pediatric community-acquired pneumonia in China].

Zhonghua Er Ke Za Zhi 2019 Jan;57(1):27-32

Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

To investigate the predominant genotypes and epidemiological characteristics of human adenovirus (HAdV) in pediatric community-acquired pneumonia (CAP) in China. This was a repeated cross sectional study. Between November 2014 and November 2016, nasopharyngeal aspirates (NPAs) or throat swabs from each hospitalized pediatric patients diagnosed as CAP in 12 hospitals in Northern and Southern China were collected. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.01.008DOI Listing
January 2019
3 Reads

Clinical management and outcomes of lacrimal sac squamous cell carcinoma.

Head Neck 2019 Jan 10. Epub 2019 Jan 10.

Department of E.N.T., Eye, Ear, Nose & Throat Hospital of FuDan University, Shanghai, China.

Background: To investigate the management and outcomes of patients with lacrimal sac squamous cell carcinoma (SCC).

Methods: This retrospective study examined 69 lacrimal sac SCC cases treated at our hospital between 1992 and 2017. The potential risk factors for prognosis, a new staging method, treatment outcomes, and complications were investigated. Read More

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http://dx.doi.org/10.1002/hed.25529DOI Listing
January 2019

Book Review: Handbook of Otolaryngology Head and Neck Surgery 2nd Edition.

Ann Plast Surg 2019 Feb;82(2):e1

Departments for Ear Nose and Throat and Maxillofacial Surgery Aintree University Hospital, Liverpool Merseyside, UK.

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http://dx.doi.org/10.1097/SAP.0000000000001588DOI Listing
February 2019