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New onset anosmia and ageusia in adult patients diagnosed with SARS-CoV-2.

Clin Microbiol Infect 2020 Jun 2. Epub 2020 Jun 2.

Chelsea and Westminster NHS Foundation Trust, 369 Fulham Road, London, SW10 9NH, UK; Imperial College London, NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK; North West London Pathology, Fulham Palace Road, London, W6 8RF, UK.

Objective: We investigated the prevalence of anosmia and ageusia in adult patients with a laboratory confirmed diagnosis of severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2).

Methods: A retrospective observational analysis of patients with SARS-CoV-2 admitted to hospital or managed in the community and their household contacts across a London population during March 1 - April 1, 2020. Symptomatology and duration were extracted from routinely collected clinical data and follow-up telephone consultations. Read More

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http://dx.doi.org/10.1016/j.cmi.2020.05.026DOI Listing

School-Based Streptococcal A Sore-Throat Treatment Programs and Acute Rheumatic Fever Amongst Indigenous Māori: A Retrospective Cohort Study.

Pediatr Infect Dis J 2020 Jun 3. Epub 2020 Jun 3.

From the Pediatric Department, University of Auckland, Auckland, New Zealand.

Background: Acute rheumatic fever (ARF) predominantly affects indigenous Māori schoolchildren in Bay of Plenty region, and more so male Māori students, especially when socioeconomically deprived. We evaluated the effectiveness of strategies for reducing ARF with group A streptococcal pharyngitis treatment in 2011-18.

Methods: We retrospectively assessed outcomes of 3 open cohorts of Māori schoolchildren receiving different interventions: Eastern Bay rural Cohort 1, mean deprivation decile 9. Read More

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http://dx.doi.org/10.1097/INF.0000000000002770DOI Listing

The Diagnosis of a Case of Household Cleaner Fatality.

Am J Forensic Med Pathol 2020 Jun 3. Epub 2020 Jun 3.

Forensic Sciences Department, Chennai, India.

Household cleaners are an unavoidable entity in our routine domestic life. They are available either in company-labeled bottles or locally made unlabeled bottles especially in the developing countries. In this report, we are discussing a case of fatal ingestion of household cleaner, which was stored in an unlabeled bottle. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000566DOI Listing

Odontogenic causes complicating the chronic rhinosinusitis diagnosis.

Clin Oral Investig 2020 Jun 4. Epub 2020 Jun 4.

Department of Virology, University of Helsinki, Helsinki, Finland.

Objectives: Chronic rhinosinusitis (CRS) frequently stems from a dental origin, although odontogenic sinusitis (OS) remains underdiagnosed amongst different professionals. This study aimed to explore how often odontogenic causes are considered when diagnosing CRS.

Materials And Methods: Patient records from 374 new CRS patients treated at a tertiary-level ear, nose, and throat (ENT) clinic were selected. Read More

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http://dx.doi.org/10.1007/s00784-020-03384-4DOI Listing

Epidemiology and Phylogenetic Analysis of Viral Respiratory Infections in Vietnam.

Front Microbiol 2020 15;11:833. Epub 2020 May 15.

Usher Institute, The University of Edinburgh, Edinburgh, United Kingdom.

Acute respiratory infections (ARIs) impose a major public health burden on fragile healthcare systems of developing Southeast Asian countries such as Vietnam. The epidemiology, genetic diversity and transmission patterns of respiratory viral pathogens that circulate in this region are not well characterized. We used RT-PCR to screen for 14 common respiratory viruses in nasal/throat samples from 4326 ARI patients from 5 sites in Vietnam during 2012-2016. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242649PMC

Correlation between dysphonia and dysphagia evolution in amyotrophic lateral sclerosis patients.

Logoped Phoniatr Vocol 2020 Jun 4:1-8. Epub 2020 Jun 4.

Department of Medicine, Surgery and Neuroscience, Ear Nose Throat Clinic, University Hospital of Siena, Siena, Italy.

Amyotrophic lateral sclerosis (ALS) is a non-demyelinating neurodegenerative disease in adults with motor disorders. It is the most prevalent neuromuscular disease worldwide. Two forms exist: a sporadic form (90% of cases) and a family form due to mutations in more than 20 genes. Read More

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http://dx.doi.org/10.1080/14015439.2020.1771766DOI Listing

COVID-19: a review.

Monaldi Arch Chest Dis 2020 May 14;90(2). Epub 2020 May 14.

Department of Computer Science, Basaveshwar Engineering College, Bagalkot.

The enduring epidemic outbreak which started in Wuhan city of China, in December 2019 caused by the 2019 novel coronavirus (COVID- 19) or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created a dangerous and deadly Public Health disaster of International apprehension, with cases confirmed in several countries. This novel community health trouble is frightening the universe with clinical, psychological, emotional, collapse of health system and economical slowdown in each and every part of the world infecting nearly 200 countries. A highly virulent and pathogenic COVID-19 viral infection with incubation period ranging from two to fourteen days, transmitted by breathing of infected droplets or contact with infected droplets, belongs to the genus Coronavirus with its high mutation rate in the Coronaviridae. Read More

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http://dx.doi.org/10.4081/monaldi.2020.1298DOI Listing

Efficacy and safety of rapid tests to guide antibiotic prescriptions for sore throat.

Cochrane Database Syst Rev 2020 Jun 4;6:CD012431. Epub 2020 Jun 4.

Department of General Pediatrics and Pediatric Infectious Diseases, AP-HP, Hôpital Necker, Paris, France.

Background: Sore throat is a common condition caused by viruses or bacteria, and is a leading cause of antibiotic prescription in primary care. The most common bacterial species is group A streptococcus ('strep throat'). Between 50% to 70% of pharyngitis cases are treated with antibiotics, despite the majority of cases being viral in origin. Read More

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http://dx.doi.org/10.1002/14651858.CD012431.pub2DOI Listing

The natural history and transmission potential of asymptomatic SARS-CoV-2 infection.

Clin Infect Dis 2020 Jun 4. Epub 2020 Jun 4.

Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.

Background: Little is known about the natural history of asymptomatic SARS-CoV-2 infection or its contribution to infection transmission.

Methods: We conducted a prospective study at a quarantine center for COVID-19 in Ho Chi Minh City, Vietnam. We enrolled quarantined people with RT-PCR-confirmed SARS-CoV-2 infection, collecting clinical data, travel and contact history, and saliva at enrolment and daily nasopharyngeal throat swabs (NTS) for RT-PCR testing. Read More

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http://dx.doi.org/10.1093/cid/ciaa711DOI Listing

COVID-19: a conundrum to decipher.

Eur Rev Med Pharmacol Sci 2020 May;24(10):5830-5841

Department of Anatomy, Biochemistry; All India Institute of Medical Sciences, Nagpur, Maharashtra, India.

Objective: Recent worldwide outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of respiratory coronavirus disease 2019 (COVID-19), is a current, ongoing life-threatening crisis, and international public health emergency. The early diagnosis and management of the disease remains a major challenge. In this review, we aim to summarize the updated epidemiology, causes, clinical manifestation and diagnosis, as well as prevention and control of the novel coronavirus SARS-CoV-2. Read More

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http://dx.doi.org/10.26355/eurrev_202005_21378DOI Listing

Viral kinetics and factors associated with rapid viral clearance during lopinavir/ritonavir-based combination therapy in non-severe COVID-19 patients.

Eur Rev Med Pharmacol Sci 2020 05;24(10):5788-5796

Department of Infectious Diseases, Ruian People's Hospital, Ruian, Zhejiang, China.

Objective: Lopinavir/ritonavir has modest antiviral activity against severe acute respiratory syndrome coronavirus 2. The aim was to investigate the viral kinetics and factors associated with viral clearance during lopinavir/ritonavir-based combination treatment in non-severe patients.

Patients And Methods: Sixty-four patients were retrospectively enrolled. Read More

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http://dx.doi.org/10.26355/eurrev_202005_21373DOI Listing

No infectious risk of COVID-19 patients with long-term fecal 2019-nCoV nucleic acid positive.

Eur Rev Med Pharmacol Sci 2020 May;24(10):5772-5777

Department of Infection Management, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, P.R. China.

Objective: It has recently been reported that some COVID-19 patients have long-term positive fecal nucleic acid after discharging from the hospital with negative nucleic acid in the respiratory tract, but it is unclear whether COVID-19 patients with positive long-term fecal nucleic acid tests have the risk of self-infection.

Patients And Methods: From January 25, 2020 to March 9, 2020, 5 COVID-19 patients with negative respiratory tract nucleic acid and positive fecal nucleic acid were observed and studied to explore whether these patients can re-infect themselves. Five patients with COVID-19 accompanied by diarrhea as the main gastrointestinal symptoms were carefully observed through clinical symptoms, imaging and other auxiliary examinations. Read More

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http://dx.doi.org/10.26355/eurrev_202005_21370DOI Listing

RET, NTRK, ALK, BRAF and MET fusions in a large cohort of pediatric papillary thyroid carcinomas.

Thyroid 2020 Jun 4. Epub 2020 Jun 4.

Institute of Endocrinology, 74796, Molecular Endocrinology, Praha, Czech Republic;

Background: Pediatric papillary thyroid carcinoma (PTC) is a rare malignancy but with an increasing incidence. Pediatric PTCs have distinct clinical and pathological features and even the molecular profile differs from adult PTCs. Somatic point mutations in pediatric PTCs have been previously described and studied, but complex information about fusion genes is lacking. Read More

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http://dx.doi.org/10.1089/thy.2019.0802DOI Listing

Gastroesophageal Reflux Disease: A Cause for Eustachian Tube Dysfunction in Obstructive Sleep Apnea.

Ear Nose Throat J 2020 Jun 4:145561320931219. Epub 2020 Jun 4.

Anzhen Hospital Sleep Center, Beijing, People's Republic of China.

Objectives: To explore the effect of gastroesophageal reflux disease (GERD) on Eustachian tube function in patients with obstructive sleep apnea (OSA).

Methods: This was a cross-sectional study. The patients were divided into 4 groups according to OSA and GERD: OSA+GERD group; OSA-only group; GERD-only group; and normal control group. Read More

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http://dx.doi.org/10.1177/0145561320931219DOI Listing

Endoscopic Ossiculoplasty for the Management of Isolated Congenital Ossicular Chain Malformation: Surgical Results in 16 Ears.

Ear Nose Throat J 2020 Jun 4:145561320931218. Epub 2020 Jun 4.

Department of Otorhinolaryngology, Head and Neck Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.

Objective: The aim of this study is to describe the clinical characteristics and intraoperative findings and further evaluate the efficacy of endoscopic ossiculoplasty for the management of isolated congenital ossicular chain malformation.

Methods: A retrospective study was performed on 16 ears (15 patients) with the isolated congenital ossicular chain malformation who underwent endoscopic ossiculoplasty in our department from May 2017 to January 2019. Endoscopic exploratory tympanotomy was conducted to check the ossicular chain; at the same time, endoscopic ossiculoplasty was performed depending on intraoperative findings. Read More

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http://dx.doi.org/10.1177/0145561320931218DOI Listing

[Meta-analysis on effectiveness and safety of Pudilan Xiaoyan Oral Liquid on child upper respiratory infection].

Zhongguo Zhong Yao Za Zhi 2020 May;45(9):2203-2209

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.

To systematically review the effectiveness and safety of Pudilan Xiaoyan Oral Liquid on child upper respiratory infection and conduct Meta-analysis. We electronically retrieved databases, including PubMed, Web of Science, VIP, WanFang and CNKI, for published articles of randomized controlled trials(RCTs) of Pudilan Xiaoyan Oral Liquid on child upper respiratory infection from inception to April 2019. According to the inclusion and exclusion criteria, two reviewers independently screened out literatures, extracted data and assessed the risk of bias in included studies. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200102.501DOI Listing

Patient-Reported Outcomes and Blood-Based Parameters Identify Response to Treatment in Eosinophilic Esophagitis.

Dig Dis Sci 2020 Jun 3. Epub 2020 Jun 3.

Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Guldhedsgatan 10A, 413 46, Göteborg, Sweden.

Background: Noninvasive methods to assess treatment response in eosinophilic esophagitis are needed.

Aims: Our aim was to determine whether a blood-based biomarker panel centered on immune parameters could identify histologic response to treatment in eosinophilic esophagitis patients.

Methods: A pilot study involving adult patients with active eosinophilic esophagitis recruited at two Ear, Nose, Throat clinics in Sweden was designed. Read More

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http://dx.doi.org/10.1007/s10620-020-06368-2DOI Listing

A model to predict postoperative complications for otorhinolaryngology and maxillofacial surgery procedures in elderly patients.

Eur Arch Otorhinolaryngol 2020 Jun 3. Epub 2020 Jun 3.

Head and Neck and Robotic Surgery, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Purpose: All kinds of ear, nose, and throat and maxillofacial surgery (ENT/MFS) procedures are being increasingly performed in the elderly although old age is a major risk factor for increased postoperative complications. With only scarce evidence on the topic, surgeons are asked to critically evaluate their procedures' indications and outcomes to balance the treatment risks and benefits. Our primary aim was to identify predictive factors for surgical outcomes in this setting and to create a predictive model for a tailored risk assessment. Read More

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http://dx.doi.org/10.1007/s00405-020-06084-7DOI Listing

A review of pathophysiology and neuropsychiatric manifestations of COVID-19.

J Neurol 2020 Jun 3. Epub 2020 Jun 3.

Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, USA.

Introduction: The outbreak of coronavirus disease 2019 (COVID-19) has become one of the most serious pandemics of the recent times. Since this pandemic began, there have been numerous reports about the COVID-19 involvement of the nervous system. There have been reports of both direct and indirect involvement of the central and peripheral nervous system by the virus. Read More

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http://dx.doi.org/10.1007/s00415-020-09950-wDOI Listing

Leukocytoclastic Vasculitis: An Early Skin Biopsy Makes a Difference.

Cureus 2020 May 1;12(5):e7912. Epub 2020 May 1.

Internal Medicine, University of Connecticut, Farmington, USA.

Leukocytoclastic vasculitis (LCV) is an uncommon condition with a broad differential diagnosis. Although the clinical history, physical examination, and laboratory workup are pivotal when formulating a differential diagnosis of LCV, a skin biopsy is required in most cases to elucidate the cause. The diagnostic yield of a skin biopsy increases within the first 24 to 48 hours of the lesion onset indicating the importance of obtaining a prompt skin sample. Read More

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http://dx.doi.org/10.7759/cureus.7912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263727PMC

Dysphagia as an Initial Manifestation of Eosinophilic Esophagitis.

Cureus 2020 Apr 30;12(4):e7898. Epub 2020 Apr 30.

Hematology and Oncology, Ashland Bellefonte Cancer Center, Ashland, USA.

Eosinophilic esophagitis (EoE) is a clinicopathological condition characterized clinically by symptoms of esophageal dysfunction, with typical endoscopic findings and intra-epithelial eosinophilia on biopsy. This case report focuses on the historical aspect of EoE, clinical manifestations, and correlation with immune disorders, medical management, and interventional management of EoE. We present a 20-year-old patient presenting with tightness in throat and odynophagia after the ingestion of certain foods. Read More

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http://dx.doi.org/10.7759/cureus.7898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263406PMC

Survey of WU and KI polyomaviruses, coronaviruses, respiratory syncytial virus and parechovirus in children under 5 years of age in Tehran, Iran.

Iran J Microbiol 2020 Apr;12(2):164-169

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background And Objectives: Severe acute respiratory infections (SARI) remain an important cause for childhood morbidity worldwide. We designed a research with the objective of finding the frequency of respiratory viruses, particularly WU and KI polyomaviruses (WUPyV & KIPyV), human coronaviruses (HCoVs), human respiratory syncytial virus (HRSV) and human parechovirus (HPeV) in hospitalized children who were influenza negative.

Materials And Methods: Throat swabs were collected from children younger than 5 years who have been hospitalized for SARI and screened for WUPyV, KIPyV, HCoVs, HRSV and HPeV using Real time PCR. Read More

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New-Onset of Crohn's Disease Is Associated with Antistreptolysin O Positive Titers.

Clin Exp Gastroenterol 2020 11;13:187-191. Epub 2020 May 11.

The Gonczarowski Family Institute of Gastroenterology and Liver Diseases, Shamir (Assaf Harofeh) Medical Center, Tel Aviv University, Tel Aviv, Israel.

Objective: Different infectious agents have been presumed to be candidates acting as an etiologic factor or trigger of Crohn's disease (CD). Group A (GAS) is a common human infection agent that can also trigger post-infectious immune-mediated conditions. The current study aimed to examine whether the immunogenic activity induced by GAS may trigger new-onset of CD. Read More

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http://dx.doi.org/10.2147/CEG.S245770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227782PMC

Identification of temporal condition patterns associated with pediatric obesity incidence using sequence mining and big data.

Int J Obes (Lond) 2020 Jun 3. Epub 2020 Jun 3.

Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Background: Electronic health records (EHRs) are potentially important components in addressing pediatric obesity in clinical settings and at the population level. This work aims to identify temporal condition patterns surrounding obesity incidence in a large pediatric population that may inform clinical care and childhood obesity policy and prevention efforts.

Methods: EHR data from healthcare visits with an initial record of obesity incidence (index visit) from 2009 through 2016 at the Children's Hospital of Philadelphia, and visits immediately before (pre-index) and after (post-index), were compared with a matched control population of patients with a healthy weight to characterize the prevalence of common diagnoses and condition trajectories. Read More

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http://dx.doi.org/10.1038/s41366-020-0614-7DOI Listing

A multi-centre, pragmatic, three-arm, individually randomised, non-inferiority, open trial to compare immediate orally administered, immediate topically administered or delayed orally administered antibiotics for acute otitis media with discharge in children: The Runny Ear Study (REST): study protocol.

Trials 2020 Jun 3;21(1):463. Epub 2020 Jun 3.

Bristol Randomised Trial Collaboration (BRTC), part of the Bristol Trial Centre, Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS82PS, UK.

Background: Acute otitis media (AOM) is a common painful infection in children, with around 2.8 million cases presenting to primary care in England and Wales annually. Nearly all children who present to their general practitioner (GP) with AOM or AOM with discharge (AOMd) are treated with orally administered antibiotics. Read More

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http://dx.doi.org/10.1186/s13063-020-04419-7DOI Listing

Comparison of gastric insufflation using LMA-supreme and I-gel versus tracheal intubation in laparoscopic gynecological surgery by ultrasound: a randomized observational trial.

BMC Anesthesiol 2020 Jun 3;20(1):136. Epub 2020 Jun 3.

Department of Anesthesiology, First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Hefei, 230022, Anhui Province, People's Republic of China.

Background: The application of bedside ultrasound to evaluate gastric content and volume can assist in determining aspiration risk. Applying positive pressure ventilation via supraglottic airway devices (SAD) can result in a degree of gastric insufflation. This study assessed and compared the antral cross-sectional area (CSA) in patients undergoing laparoscopic gynecological surgery when managed with different SAD. Read More

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http://dx.doi.org/10.1186/s12871-020-01057-zDOI Listing

Resveratrol inhibits proliferation and promotes apoptosis of keloid fibroblasts by targeting HIF-1α.

J Plast Surg Hand Surg 2020 Jun 4:1-7. Epub 2020 Jun 4.

Department of Plastic Surgery, Peking Union Medical College Hospital, Beijing, China.

A keloid is characterized by red, tickling, hard, and irregular raised tissues, and it tends to outgrow its origin. It frequently occurs in young adults and appears to be refractory to prevailing therapies. Resveratrol is a new drug that has anti-proliferative effect. Read More

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http://dx.doi.org/10.1080/2000656X.2020.1771719DOI Listing

Anatomical Variations in Recurrent Laryngeal Nerves in Thyroid Surgery.

Ear Nose Throat J 2020 Jun 4:145561320927565. Epub 2020 Jun 4.

Department of Pathology, Jingzhou No. 1 People's Hospital and First Affiliated Hospital of Yangtze University, Hubei Province, China.

Objective: To study terminal bifurcation of recurrent laryngeal nerves (RLNs) with original direction to larynx entry and to decrease the risk of vocal cord paralysis in thyroid patients.

Methods: The RLNs of 294 patients (482 sides) were dissected according to the branches into the larynx, and the original direction of each RLN trunk in thyroid surgery was recorded.

Results: (1) About 30. Read More

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http://dx.doi.org/10.1177/0145561320927565DOI Listing

High-Coverage SARS-CoV-2 Genome Sequences Acquired by Target Capture Sequencing.

J Med Virol 2020 Jun 3. Epub 2020 Jun 3.

Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510700, China.

In this study, we designed a set of SARS-CoV-2 enrichment probes to increase the capacity for sequence-based virus detection and obtain the comprehensive genome sequence at the same time. This universal SARS-CoV-2 enrichment probe set contains 502 120nt ssDNA biotin-labeled probes designed based on all available SARS-CoV-2 viral sequences and it can be used to enrich for SARS-CoV-2 sequences without prior knowledge of type or subtype. Following the CDC health and safety guidelines, marked enrichment was demonstrated in a virus strain sample from a cell culture, three nasopharyngeal swab samples (cycle threshold [Ct] values: 32. Read More

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http://dx.doi.org/10.1002/jmv.26116DOI Listing

A dental implant dislocated in the ethmoidal sinus: A case report.

Heliyon 2020 May 27;6(5):e03977. Epub 2020 May 27.

IRCCS Centro Neurolesi "Bonino Pulejo", Messina, Italy.

Maxillary sinusitis can represent a rare complication of dental implants of endodontic materials impinging in the maxillary sinuses. The effects of anatomical variants of paranasal sinuses on pathophysiological and clinical manifestations of dental sinusitis are poorly understood. Herein, we present a case of dislocation of a dental implant in the ethmoidal sinus in a 63-years old man with bilateral accessory maxillary orifice. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260438PMC

Recurrent Ameloblastoma Involving Fibula Neo-mandible: Management with Digital Planning and Reconstruction Using a Contralateral Free Fibula Flap.

Cureus 2020 Apr 29;12(4):e7880. Epub 2020 Apr 29.

Maxillofacial Surgery, St. James's Hospital, Dublin, IRL.

Ameloblastoma is a locally aggressive tumor that most commonly arises in the mandible. It has a high rate of recurrence if inadequately excised. We report a case of a patient who developed recurrence of his ameloblastoma in his fibula flap mandibular reconstruction despite clear resection margins 23 years after resection. Read More

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http://dx.doi.org/10.7759/cureus.7880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255542PMC

COVID-19 and Renal Failure: Challenges in the Delivery of Renal Replacement Therapy.

J Clin Med Res 2020 May 8;12(5):276-285. Epub 2020 May 8.

Division of Nephrology, Lynchburg Nephrology Physicians, Lynchburg, VA, USA.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first officially reported in December 2019 in Wuhan City, Hubei province, China, and has since lead to a pandemic. Most cases result in minor symptoms such as cough, fever, sore throat, myalgia, fatigue, nausea, diarrhea, loss of smell, and abdominal pain. As of April 8, 2020, more than 1,485,000 cases of COVID-19 have been reported in more than 200 countries and territories, resulting in over 90,000 deaths. Read More

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http://dx.doi.org/10.14740/jocmr4160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239583PMC

carriage state in healthy adult population and phenotypic and genotypic properties of isolated strains.

Postepy Dermatol Alergol 2020 Apr 5;37(2):184-189. Epub 2020 May 5.

Laboratory of Environmental and Occupational Hazards, University of Life Sciences, Lublin, Poland.

Introduction: At present, infections induced by staphylococci, especially methicillin-resistant (MRSA) are one of key therapeutic and epidemiological problems.

Aim: The assessment of carrier state occurrence among a healthy adult population as well as determination of phenotypic and genotypic properties of the isolated strains.

Material And Methods: The study included 100 healthy individuals. Read More

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http://dx.doi.org/10.5114/ada.2020.94837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262795PMC

Isolation of ultrasmall (filterable) bacteria from patients suffering from ME, and patients and staff of a paediatric hospital.

Saudi J Biol Sci 2020 Jun 13;27(6):1566-1568. Epub 2020 Mar 13.

Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.

A total of 108 blood samples obtained from 28 male and 80 female patients diagnosed with ME were diluted in sterile, Ringer's Solution and forced (by suction) through 0.2 µm filters. Of the 28 male samples, 4 yielded filterable bacteria and of the 80 female samples, 18 gave filterable bacteria; as a result, of the total of 124 samples, 22 yielded FB. Read More

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http://dx.doi.org/10.1016/j.sjbs.2020.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253900PMC

Trends and clinicopathological characteristics of oral squamous cell carcinomas reported at a tertiary cancer hospital in Nepal during 1999 to 2009.

Clin Exp Dent Res 2020 Jan 12. Epub 2020 Jan 12.

Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.

Objective: Reliable data describing the trends and clinicopathological characteristics of oral squamous cell carcinoma (OSCC) in the Nepalese population are very limited. The current study aimed to examine the demographics, trend, and clinicopathological characteristics of OSCC reported to the main referral/tertiary cancer hospital, the B.P. Read More

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http://dx.doi.org/10.1002/cre2.278DOI Listing
January 2020

Signet Ring Cell Differentiation in Salivary Duct Carcinoma with Rhabdoid Features: Report of Three Cases and Literature Review.

Head Neck Pathol 2020 Jun 2. Epub 2020 Jun 2.

Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

Salivary duct carcinoma with rhabdoid features (SDCRF) is a rare salivary tumor with poor prognosis and is proposed as a salivary counterpart of pleomorphic lobular carcinoma of the breast (PLCB). Here, we report three cases of SDC with rhabdoid features (SDCRF) mimicking PLCB. Pleomorphic adenoma (PA) component was accompanied in all the cases confirming carcinoma ex PA. Read More

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http://dx.doi.org/10.1007/s12105-020-01186-4DOI Listing

Association Between Structure-function Characteristics and Visual Field Outcomes in Glaucoma Subjects with Intraocular Pressure Reduction After Trabeculectomy.

J Glaucoma 2020 Jun 1. Epub 2020 Jun 1.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

Precis: Improvements in post-trabeculectomy visual field outcomes were found to be significantly associated with pre-operative nerve fiber layer thickness parameters extracted from the sectorized structure-function relationship, baseline visual field and severity of glaucoma.

Objective: To determine whether the pre-operative structure-function relationship helps to predict visual outcomes at one-year post-trabeculectomy.

Patients And Methods: 91 eyes from 87 participants who successfully underwent trabeculectomy were included in our study. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001550DOI Listing

Retinoids Augment Thiazolidinedione PPARγ Activation in Oral Cancer Cells.

Anticancer Res 2020 Jun;40(6):3071-3080

Department of Otolaryngology-Head and Neck Surgery, University of Minnesota, Minneapolis, MN, U.S.A.

Background/aim: Head and neck squamous cell carcinoma affects nearly 500,000 people annually. Augmenting PPARγ functional activation is linked with multiple anti-carcinogenic processes in aerodigestive cell lines and animal models. PPARγ/RXRα heterodimers may be key partners in this activation. Read More

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http://dx.doi.org/10.21873/anticanres.14288DOI Listing

Optic neuropathy caused by expanded Onodi cell mucocele.

BMJ Case Rep 2020 Jun 2;13(6). Epub 2020 Jun 2.

Department of Otorhinolaryngology, Asahi General Hospital, Asahi, Chiba, Japan.

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http://dx.doi.org/10.1136/bcr-2020-235311DOI Listing

Intralaryngeal paraganglioma workup and discussion of surgical approach.

BMJ Case Rep 2020 Jun 2;13(6). Epub 2020 Jun 2.

Otolarynology-Head & Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.

Laryngeal paragangliomas are an uncommon presentation of head and neck paragangliomas, with laryngeal paragangliomas along with a synchronous paraganglioma being exceptionally rare. We present two challenging cases of laryngeal paragangliomas with extralaryngeal extension, completely resected through a transcervical approach without endolaryngeal disruption, with one case having synchronous bilateral carotid body tumours. Both patients had excellent results with complete tumour resection and no resultant functional impact. Read More

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http://dx.doi.org/10.1136/bcr-2020-234745DOI Listing

Echinacea can help with Azithromycin in prevention of recurrent tonsillitis in children.

Am J Otolaryngol 2019 Nov 12:102344. Epub 2019 Nov 12.

Otolaryngology, Head and Neck Department, Minia University Hospital, 122 Kornish El-Neel Street, Minia City, Minia, Egypt. Electronic address:

Purpose: Recurrent tonsillitis in children is a common disease affecting children quality of life and extends to their families. The aim of this study was to assess the effect of combined use of oral Azithromycin (AZT) plus Echinacea compared to exclusive use of AZT in children with recurrent tonsillitis.

Material And Methods: A prospective comparative study including three groups of children with recurrent tonsillitis. Read More

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http://dx.doi.org/10.1016/j.amjoto.2019.102344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132457PMC
November 2019

Mechanism of dysphagia after acute traumatic cervical spinal cord injury.

J Neurotrauma 2020 Jun 3. Epub 2020 Jun 3.

Spinal Injuries Center, 73491, Department of Orthopedic Surgery, Iizuka, Fukuoka, Japan;

Introduction: Swallowing dysfunction, which may cause aspiration pneumonia, is one of the most important complications of treatment of traumatic cervical spinal cord injury (CSCI); however, the mechanism of dysphagia is not well understood. No previous studies have reported the association between morphological changes of the soft tissue and dysphagia. We aimed to determine the factors associated with severity of dysphagia following CSCI and elucidate its mechanism. Read More

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http://dx.doi.org/10.1089/neu.2020.6983DOI Listing

Comparison of Prodromal Symptoms of Patients with Behavioral Variant Frontotemporal Dementia and Alzheimer Disease.

Dement Geriatr Cogn Disord 2020 Jun 2:1-9. Epub 2020 Jun 2.

Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland,

Introduction: Behavioral variant frontotemporal dementia (bvFTD) is the most common clinical subtype of frontotemporal lobar degeneration. bvFTD is often characterized by changes in behavior and personality, frequently leading to psychiatric misdiagnoses. On the other hand, substantial clinical overlap with other neurodegenerative diseases, such as Alzheimer disease (AD), further complicates the diagnostics. Read More

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http://dx.doi.org/10.1159/000507544DOI Listing

Cochlear Implantation in Candidates With Moderate-to-Severe Hearing Loss and Poor Speech Perception.

Laryngoscope 2020 Jun 2. Epub 2020 Jun 2.

ENT Department, University Hospital Erlangen, Erlangen, Germany.

Objectives/hypothesis: To determine the improvement in word recognition score (WRS ) after cochlear implant (CI) surgery in hearing aid (HA) users with preoperative hearing threshold ≤80 dB HL and inadequate speech recognition scores with HA. Secondarily, to identify predictive factors for WRS with a CI (WRS [CI]) 6 months after surgery, derived from the standard German CI preoperative assessment.

Study Design: Retrospective chart review. Read More

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http://dx.doi.org/10.1002/lary.28771DOI Listing

Oesophageal foreign bodies in cats: Clinical and anatomic findings.

PLoS One 2020 2;15(6):e0233983. Epub 2020 Jun 2.

Internal Medicine and Infectious Diseases Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Background: Anatomical feline models can aid in understanding the relationships between clinical findings and anatomical features and the course of foreign bodies passing through the oesophagus. This study has two goals 1) to assess feline oesophageal foreign bodies in feline patients using physical, radiologic and endoscopic examination and, how their location influences treatment plans and complications. 2) How the anatomical sharp angle of the oesophagus contribute to foreign body lodgement. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233983PLOS
June 2020
3.234 Impact Factor

Telemedicine and the Interdisciplinary Clinic Model: During the COVID-19 Pandemic and Beyond.

Otolaryngol Head Neck Surg 2020 Jun 2:194599820932167. Epub 2020 Jun 2.

Department of Otolaryngology-Head and Neck Surgery, University of Washington Medical Center, Seattle, Washington, USA.

The emergence of the novel coronavirus disease 2019 (COVID-19) and the subsequent need for physical distancing have necessitated a swift change in health care delivery. Prior to the COVID-19 outbreak, many institutions utilized an interdisciplinary clinic model including both a laryngologist and a speech-language pathologist for the evaluation of patients with voice, swallowing, and upper airway disorders. To improve access, many providers are pursuing the use of interdisciplinary telemedicine to provide individualized patient-centered care while allowing for physical distancing. Read More

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http://dx.doi.org/10.1177/0194599820932167DOI Listing

Metastatic Tracheal Tumor of Thyroid Origin: Endoscopic Diode Laser Treatment Combined With Thyroidectomy, Radioactive Iodine, and Radiotherapy.

Ear Nose Throat J 2020 Jun 2:145561320931214. Epub 2020 Jun 2.

MicroDiagnostics Ltd, Private Surgical Pathology, Cytopathology and Molecular Diagnostics Laboratory, Thessaloniki, Greece.

Tracheal metastasis from papillary thyroid carcinoma (PTC) is an unprecedented and rare entity. We present the case of a 65 year-old lady who suffered from dyspnea and a thyroid goiter that turned out to be PTC. A magnetic resonance imaging (MRI) scan of the lungs revealed a huge tracheal mass causing obstruction of the tracheal lumen. Read More

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http://dx.doi.org/10.1177/0145561320931214DOI Listing