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J Stomatol Oral Maxillofac Surg 2022 Jun 24. Epub 2022 Jun 24.

Adjunct professor, Joseph Ayobaalola University, Ikeji-Arakeji, Nigeria; Honorary professor, Dr DY Patil University, Pune, India; visiting professor, Faculty of Medicine, University of Nis, Serbia.

Int J Pediatr Otorhinolaryngol 2022 Jun 13;159:111206. Epub 2022 Jun 13.

Department of Otolaryngology, Penn State Milton S Hershey Medical Center, 500 University Drive, Hershey, PA, United States.

Objectives: Transoral robotic surgery in adults confers excellent results and decreased morbidity. Application of these techniques has not yet been rigorously investigated in children. The goal of this study is to evaluate the feasibility of a flexible robotic surgical system in a pediatric population. Read More

Oral Oncol 2022 Jun 24;132:105984. Epub 2022 Jun 24.

Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy; C.I.N.B.O. (Consorzio Interuniversitario Nazionale per la Bio-Oncologia), Chieti, Italy. Electronic address:

Wien Med Wochenschr 2022 Jun 27. Epub 2022 Jun 27.

Department of Anaesthesiology and Intensive Care Unit, Cantonal Hospital Zenica, Zenica, Bosnia and Herzegovina.

Background: Adenotonsillectomy is the most commonly performed surgery in the pediatric population. Hemorrhage after adenotonsillectomy, which can occur at any time postoperatively, is one of the most serious complications.

Objective: To determine the frequency of hemorrhage in children after adenotonsillectomy and to compare postoperative hemorrhage with regard to age and sex. Read More

Eur Arch Otorhinolaryngol 2022 Jun 27. Epub 2022 Jun 27.

Ichijo Ear, Nose and Throat Clinic, 3-2-1, Ekimae, Hirosaki, 036-8002, Japan.

Background: The diagnostic characteristics of patients with cupulolithiasis of the posterior semicircular canal are persistent torsional nystagmus in the supine position and persistent torsional nystagmus (opposite direction) in the nose-down position, which are caused by the affected canal becoming gravity sensitive.

Objective: To investigate the clinical features of posterior cupulolithiasis.

Materials And Methods: We interviewed 30 consecutive patients with cupulolithiasis of the posterior canal and categorized them by onset time into the following four groups: (1) during sleep; (2) at the time of awakening; (3) morning; and (4) afternoon. Read More

Ear Nose Throat J 2022 Jun 27:1455613221111734. Epub 2022 Jun 27.

Department of Otorhinolaryngology, 74654Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.

Kaposi's sarcoma (KS) is a vascular sarcoma derived from vascular endothelial cells and presents with multiple lesions. It mainly appears on the skin and oral mucosa, usually in the face, oral mucosa, and genitals. Very few cases of primary lesions in the nasal cavity have been reported. Read More

Physiol Rep 2022 Jun;10(12):e15367

Sydney Heartburn Clinic, Concord Hospital, University of Sydney, Sydney, Australia.

The aim of this study was to characterise pulmonary aspiration of refluxate in patients with gastroesophageal reflux disease (GORD) and laryngopharyngeal reflux (LPR) by continuous pulse oximetry (SpO2) during the supine phase of a scintigraphic reflux study. Variables assessed for significance included age, hiatus hernia, frequency, amplitude of reflux and clearance of reflux from the oesophagus/pharynx. The patients included in this study had established GORD and LPR by clinical history. Read More

Front Neurosci 2022 10;16:888596. Epub 2022 Jun 10.

Department of Ear, Nose, and Throat, The First Affiliated Hospital of Soochow University, Suzhou, China.

Compared to normal-hearing (NH) listeners, cochlear implant (CI) listeners have greater difficulty segregating competing speech. Neurophysiological studies have largely investigated the neural foundations for CI listeners' speech recognition in quiet, mainly using the P300 component of event-related potentials (ERPs). P300 is closely related to cognitive processes involving auditory discrimination, selective attention, and working memory. Read More

Clin Case Rep 2022 Jun 15;10(6):e05794. Epub 2022 Jun 15.

Department of Otolaryngology and Head and Neck Surgery Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy.

Silent sinus syndrome (SSS) is a rare clinical condition, commonly unilateral, secondary to the obstruction of the osteomeatal complex, subsequent negative pressure in the maxillary sinus, and collapse of the orbit floor and sinus walls. We describe a case of unilateral SSS treated by means of functional endoscopic sinus surgery. Read More

J Immunol Res 2022 14;2022:7783481. Epub 2022 Jun 14.

Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital, Fudan University, 83 Fenyang Road, Xuhui District, Shanghai 200031, China.

To identify the effect of long noncoding RNA (lncRNA) FR215775 in regulating CD4+ T cells on murine models of allergic rhinitis (AR), the expression of lncRNA FR215775 in primary Th2 cells was detected through qRT-PCR. After knocking down the expression of lncRNA FR215775 via Sh-FR215775-Ads, Cell Counting Kit-8, cytometric bead array, and fluorescence-activated cell sorting were performed to determine its functions in vitro. Moreover, lncRNA FR215775-silencing or nonsilencing cells were injected intravenously into AR mice. Read More

Radiol Case Rep 2022 Sep 17;17(9):2963-2967. Epub 2022 Jun 17.

Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.

Massive recurrent epistaxis because of traumatic pseudoaneurysm of the sphenopalatine artery is rarely diagnosed. It is formed by partial rupture of the endothelium by facial trauma and managed with embolization and maxillofacial reconstruction. Here, we report a case of 2 massive recurrent epistaxes and 1 case of carotid cavernous fistula, which needed embolization to control the recurrent bleeding following trauma. Read More

Front Genet 2022 9;13:907985. Epub 2022 Jun 9.

Department of Laboratory Medicine, The First Affiliated Hospital of Xiamen University, Xiamen Key Laboratory of Genetic Testing, School of Medicine, Xiamen University, Xiamen, China.

Head and neck squamous cell carcinoma (HNSCC) arises from squamous cells in the oral cavity, pharynx and larynx. Although HNSCC is sensitive to radiotherapy, patient prognosis is poor. Necroptosis is a novel programmed form of necrotic cell death. Read More

Int J Surg Case Rep 2022 Jun 22;96:107336. Epub 2022 Jun 22.

Respiratory & Critical Care Specialists, Children's Minnesota, Minneapolis, MN 55404, The United States of America. Electronic address:

Introduction: Hybrid lesions of intralobar sequestration (ILS) associated with congenital pulmonary airway malformation (CPAM) is rare and could be undetected by prenatal ultrasound. Some of the cases are discovered incidentally or following lung infection in late childhood or adulthood.

Case Presentation: 17-year-old female developed chest pain, non-productive cough, low grade fever, and sore throat several weeks following SARS-CoV-2 infection. Read More

Ann Emerg Med 2022 Jun 22. Epub 2022 Jun 22.

Otolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.

Study Objective: To determine the effectiveness of intranasal topical application of tranexamic acid in reducing the need for anterior nasal packing and determine the number of episodes of rebleeding in adult patients presenting with spontaneous atraumatic anterior epistaxis.

Methods: This study was a double-blind randomized trial conducted from September to November 2021 in the ears, nose, and throat (ENT) emergency department (ED), Khalili Hospital, Shiraz, Iran. Cotton pledgets soaked in either phenylephrine and lidocaine (control group) or tranexamic acid with phenylephrine and lidocaine (intervention group) were inserted into the patients' nostrils for 15 minutes. Read More

Zhonghua Er Ke Za Zhi 2022 Jun 15;60(7):671-675. Epub 2022 Jun 15.

Department of Infection,Tianjin Children's Hospital (Children's Hospital of Tianjin University) Machang Campus, Tianjin 300074, China.

To investigate the clinical characteristics and vaccination status of SARS-CoV-2 Omicron variant infected children. A total of 105 children infected with Omicron variant admitted to Tianjin Haihe Hospital (designated referral hospital for SARS-CoV-2 infection in Tianjin) from January 8, 2022 to February 3 were included for a retrospective study. The cases were divided into pneumonia group and non-pneumonia group according to chest imaging. Read More

Otolaryngol Clin North Am 2022 Jun 21. Epub 2022 Jun 21.

Voicedoctor Private Practice, 909 Northwest 18th Avenue, Portland, OR 97209, USA. Electronic address:

Feminization Laryngoplasty evolved from the aim to change a voice from a male quality to a female quality. Larynx and pharynx in a male have undergone enlargement during puberty and as there is no endocrine method for shrinking structures, a surgery that reduces the size of male structures toward the size of female structures might appropriately alter the voice. A smaller larynx and pharynx might raise both the fundamental frequency of the voice and the resonant frequency of the vocal tract. Read More

J Epidemiol Community Health 2022 Jun 24. Epub 2022 Jun 24.

The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales, Australia.

Background: While many high-income countries including Australia have successfully implemented a range of tobacco control policies, smoking remains the leading preventable cause of cancer death in Australia. We have projected Australian mortality rates for cancer types, which have been shown to have an established relationship with cigarette smoking and estimated numbers of cancer deaths attributable to smoking to 2044.

Methods: Cancer types were grouped according to the proportion of cases currently caused by smoking: 8%-30% and >30%. Read More

BMJ Case Rep 2022 Jun 24;15(6). Epub 2022 Jun 24.

Hematology and Medical Oncology, Oakland University William Beaumont School of Medicine, Troy, Michigan, USA.

Circulating tumour DNA (ctDNA) is defined as short DNA sequences shed by tumour cells into the systemic circulation. A promising use of ctDNA includes the detection of minimal residual disease (MRD) and is currently being studied in multiple types of solid tumours. Literature for the use of individualised ctDNA in nasopharyngeal carcinoma (NPC) is not available, although circulating Epstein-Barr virus DNA level is validated as a prognostic factor. Read More

Int J Gen Med 2022 17;15:5681-5691. Epub 2022 Jun 17.

Medical Physiology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Background: COVID-19 (SARS-CoV-2/2019-nCoV) is now a major public health threat to the world. Olfactory dysfunctions (ODs) are considered potential indicating symptoms and early case identification triaging for coronavirus disease 2019 (COVID-19). The most common reported comorbidities are diabetes mellitus, chronic lung disease, and cardiovascular disease. Read More

Cureus 2022 Jun 19;14(6):e26087. Epub 2022 Jun 19.

Orthopaedics, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, JPN.

Airway narrowing due to trauma-induced retropharyngeal hematoma is rare. However, it is dangerous to overlook this lesion because it can lead to airway obstruction and even death. In this article, we report a case of a patient who developed pharyngeal pain and dysphagia two days after bruising on the forehead due to a fall and required intubation management. Read More

Cureus 2022 Jun 18;14(6):e26068. Epub 2022 Jun 18.

ENT, İstanbul Yeni Yüzyıl University, Faculty of Medicine, Gaziosmanpaşa Hastanesi, İstanbul, TUR.

Introduction Benign paroxysmal positional vertigo (BPPV) is a type of vertigo and its signs are short-time, severe attacks that occur in certain head and body positions. Recent studies have revealed that vitamin D deficiency correlates with BPPV and this is explained by cupulolithiasis and canalithiasis theories. Method In the present study, levels of serum vitamin D in the patients who were diagnosed as BPPV and those in the control group consisting of healthy individuals were investigated. Read More

Sensors (Basel) 2022 Jun 13;22(12). Epub 2022 Jun 13.

Graduate School of Informatics and Engineering, University of Electro-Communications, 1-5-1, Chofugaoka, Chofu-shi 182-8585, Japan.

In this study, we propose a method to reduce noise from speech obtained from a general microphone using the information of a throat microphone. A throat microphone records a sound by detecting the vibration of the skin surface near the throat directly. Therefore, throat microphones are less prone to noise than ordinary microphones. Read More

Pharmaceuticals (Basel) 2022 Jun 3;15(6). Epub 2022 Jun 3.

Department of Biomedical Engineering, University of Massachusetts, Lowell, MA 01854, USA.

Effective pulmonary drug delivery using a metered-dose inhaler (MDI) requires a match between the MDI sprays, the patient's breathing, and respiratory physiology. Different inhalers generate aerosols with distinct aerosol sizes and speeds, which require specific breathing coordination to achieve optimized delivery efficiency. Inability to perform the instructed breathing maneuver is one of the frequently reported issues during MDI applications; however, their effects on MDI dosimetry are unclear. Read More

J Pers Med 2022 Jun 9;12(6). Epub 2022 Jun 9.

Unit of Otorhinolaryngology Head and Neck Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Previous studies have demonstrated that both subcutaneous (SCIT) and sublingual specific immunotherapy (SLIT) are effective in treating allergic rhinitis (AR). Further studies have evaluated the efficacy of allergen-specific immunotherapy (AIT) on different ear, nose, and throat (ENT) manifestations, in which allergy might have an etiopathogenetic role, such as local allergic rhinitis (LAR), rhinosinusitis (RS), otitis media (OM), and adenotonsillar (AT) disease. Nevertheless, the management of allergy in ENT diseases is still debated. Read More

J Pers Med 2022 May 29;12(6). Epub 2022 May 29.

Department of Head-Neck and Sensory Organs, Catholic University of Sacred Heart, 00168 Rome, Italy.

: Local and systemic corticosteroids have long been the workhorse in management of chronic rhinosinusitis with nasal polyps (CRSwNP), although there is no universally accepted modality of prescription. We carried out a survey in Italy to capture current trends in the use of topical and systemic corticosteroids in patients with CRSwNP. : A survey was set up on Survey Monkey. Read More

J Clin Med 2022 Jun 20;11(12). Epub 2022 Jun 20.

Department of Basic Medical Sciences, Neurosciences and Sensory Organs (SMBNOS), Section of Human Anatomy and Histology, University of Bari "Aldo Moro", I-70124 Bari, Italy.

Sjögren's syndrome (SS) is a systemic chronic autoimmune disorder characterized by lymphoplasmacytic infiltration of salivary glands (SGs) and lacrimal glands, causing glandular damage. The disease shows a combination of dryness symptoms found in the oral cavity, pharynx, larynx, and vagina, representing a systemic disease. Recent advances link chronic inflammation with SG fibrosis, based on a molecular mechanism pointing to the epithelial to mesenchymal transition (EMT). Read More

J Clin Med 2022 Jun 15;11(12). Epub 2022 Jun 15.

School of Medicine, Trinity College Dublin, D02 R590 Dublin, Ireland.

(1) Introduction: A subset of individuals experiencing long COVID symptoms are affected by 'brain fog', a lay term that often refers to general cognitive dysfunction but one that is still poorly characterised. In this study, a comprehensive clinical characterisation of self-reported brain fog was conducted vis-à-vis other long COVID symptoms and parameters of mental, cognitive, and physical health. (2) Methodology: Adult participants reporting long COVID symptoms were recruited from hospital clinics and as self-referrals. Read More

Brain Sci 2022 Jun 2;12(6). Epub 2022 Jun 2.

Department of Ear, Nose, and Throat, Shaanxi Provincial People's Hospital, Xi'an 710068, China.

The relative benefit of ipsilateral, contralateral, and bilateral repetitive transcranial magnetic stimulation (rTMS) for tinnitus treatment remains unclear, especially for patients with lateralized tinnitus. In this study, we compared outcomes after 10 sessions of 1-Hz rTMS at 110% of resting motor threshold over a two-week period. In total, 104 right-handed patients with lateralized subjective tinnitus were randomly divided into four groups according to rTMS treatment: Left ( = 29), Right ( = 23), Bilateral ( = 30), and Sham stimulation ( = 22). Read More

Brain Sci 2022 May 31;12(6). Epub 2022 May 31.

NIHR Nottingham Biomedical Research Centre, Ropewalk House, 113 The Ropewalk, Nottingham NG1 5DU, UK.

The Tinnitus Functional Index (TFI) was developed to be responsive to small treatment-related changes in the impact of tinnitus. Yet, no studies have integrated anchor-based and distribution-based techniques to produce a single Minimal Important Change (MIC) score. Here, we evaluated the responsiveness and interpretability of the TFI, determining for the first time a robust MIC score in a UK clinical population. Read More

Diagnostics (Basel) 2022 Jun 20;12(6). Epub 2022 Jun 20.

Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA.

The world is grappling with the coronavirus disease 2019 (COVID-19) pandemic, the causative agent of which is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 symptoms are similar to the common cold, including fever, sore throat, cough, muscle and chest pain, brain fog, dyspnoea, anosmia, ageusia, and headache. The manifestation of the disease can vary from being asymptomatic to severe life-threatening conditions warranting hospitalization and ventilation support. Read More