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Cochlear Implants Int 2019 May;20(3):105

a Honorary Consultant Surgeon , University College Hospital and Royal National Throat Nose and Ear Hospital , London.

BMC Med Genet 2019 Mar 20;20(1):42. Epub 2019 Mar 20.

Department of Ophthalmology and the Eye Institute, Eye and Ear, Nose, and Throat Hospital, Fudan University, 83 Fenyang Rd, Shanghai, People's Republic of China.

Background: Congenital cataract is the most common cause of blindness among children worldwide. The aim of this study was to identify causative mutations in a Chinese family with isolated autosomal dominant posterior subcapsular cataract.

Methods: The proband and her parents underwent full ophthalmological examinations. Read More

Zhonghua Yi Xue Za Zhi 2019 Mar;99(11):829-833

Department of Microbiology, Peking University Health Science Center, Beijing 100191, China.

To investigate pathogenic bacteria and drug resistance in the patients with skin and soft tissue infection in order to provide the scientific evidences for clinical reasonable use of antibiotics. A retrospective analysis was performed on patients with skin and soft tissue infections in Department of Dermatology, Peking University Third Hospital from January 2012 to December 2017. Pus, secretions, skin lesions, urine, throat swabs, and alveolar lavage fluid were collected for bacterial culture, bacterial species were identified by VITEK2 Compact system and BD-Bruker MALDI Biotyper system. Read More

Scand J Surg 2019 Mar 20:1457496919835988. Epub 2019 Mar 20.

3 Section of Paediatric Surgery, Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland.

Background And Aims:: To evaluate hospital care of children with congenital upper limb defects.

Materials And Methods:: Three hundred and sixty-two children with an upper limb defect, born 1993-2005, and alive after birth admission were identified in the Finnish Register of Congenital Malformations. The data on hospital care, with focus on operative treatment, were collected from the National Hospital Discharge Register, until 31 December 2009. Read More

Cureus 2019 Jan 6;11(1):e3831. Epub 2019 Jan 6.

Emergency Medicine, Dalhousie University, Halifax, CAN.

This case report describes a middle-aged patient with a past history of migraine headaches, who presented to the emergency department with a new onset of headaches around his left eye that were different from the pattern and character of his usual migraine headaches. The pain was severe, brief, and stabbing in nature, lasting only seconds, and occurring over intervals of a few minutes. His vital signs, including glucose, were normal. Read More

Cureus 2018 Dec 11;10(12):e3720. Epub 2018 Dec 11.

Cardiology, Saint Vincent Hospital, Worcester, USA.

Dual antiplatelet therapy (DAPT) is widely recognized as the mainstay of treatment after percutaneous coronary intervention (PCI). Premature discontinuation may pose a risk of in-stent thrombosis, acute myocardial infarction, and death. With the increased usage of antiplatelet agents, increased attention has been drawn to their potential allergic reactions. Read More

Ecol Evol 2019 Mar 30;9(5):2755-2764. Epub 2019 Jan 30.

Department of Chemistry Fujita Health University School of Health Sciences Toyoake Aichi Japan.

Pigment-based plumage coloration and its physiological properties have attracted many researchers to explain the evolution of such ornamental traits. These studies, however, assume the functional importance of the predominant pigment while ignoring that of other minor pigments, and few studies have focused on the composition of these pigments. Using the pheomelanin-based plumage in two swallow species, we studied the allocation of two pigments (the predominant pigment, pheomelanin, and the minor pigment, eumelanin) in relation to physiological properties and viability in populations under a natural and sexual selection. Read More

Development 2019 Mar 19. Epub 2019 Mar 19.

Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California 92093, USA

The embryo is an important model for analyzing mechanisms of cell fate specification and tissue morphogenesis. Sophisticated lineaging approaches for analyzing embryogenesis have been developed but are labor-intensive and do not naturally integrate morphogenetic readouts. To enable the rapid classification of developmental phenotypes, we developed a high-content method that employs two custom strains: a Germ Layer strain expressing nuclear markers in the ectoderm, mesoderm and endoderm/pharynx, and a Morphogenesis strain expressing markers labeling epidermal cell junctions and the neuronal cell surface. Read More

BMJ Case Rep 2019 Mar 18;12(3). Epub 2019 Mar 18.

Otorhinolaryngology, Hospital of Sion, Sion, Switzerland.

The impact of metastasis to the retropharyngeal lymph node group is poorly understood because of the difficult access to the retropharyngeal space (RPS). In 20%-50% of surgically treated oropharyngeal, hypopharyngeal, and cervical oesophageal carcinomas, we can find metastases to the retropharyngeal lymph nodes (RPLNs). The use of a three-dimensional (3D)-imaging-guided navigation system to perform a biopsy for a suspicion of metastasis in an RPLN can provide advantages in terms of better precision and 3D orientation with protection of the surrounding critical structures. Read More

Int J Pharm 2019 Mar 16. Epub 2019 Mar 16.

Drug Discovery, Delivery and Patient Care (DDDPC) Theme, School of Life Sciences, Pharmacy and Chemistry, Department of Pharmacy, Kingston University London, Kingston upon Thames, Surrey, KT1 2EE, United Kingdom. Electronic address:

Quantitative analysis using proton NMR (H qNMR) has been employed in various areas such as pharmaceutical analysis (e.g., dissolution study), vaccines, natural products analysis, metabolites, and macrolide antibiotics in agriculture industry. Read More

Dysphagia 2019 Mar 19. Epub 2019 Mar 19.

Department of Ear, Nose & Throat, Queen Mary Hospital, Hong Kong SAR, China.

Dysphagia is a common sequela post chemo/radiotherapy for nasopharyngeal carcinoma (NPC), with cricopharyngeal dysfunction often a contributing factor. This study examined the impact of balloon dilation of the cricopharyngeus and cervical oesophagus on swallow competence for dysphagic patients with cricopharyngeal dysfunction post NPC. Patients with NPC were screened for dysphagia and cricopharyngeal dysfunction using fiberoptic endoscopic evaluation. Read More

Eur Arch Otorhinolaryngol 2019 Mar 19. Epub 2019 Mar 19.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Purpose: We aimed to obtain information on the number of Nordic centers performing tracheal resections, crico-tracheal resections, and laryngo-tracheal reconstructions, as well as the patient volume and the standard regimens associated with these procedures.

Methods: Consultants at all Departments of Otorhinolaryngology-Head and Neck Surgery (ORL-HNS, n = 22) and Thoracic Surgery (n = 21) in the five Nordic countries were invited (April 2018-January 2019) to participate in an online survey.

Results: All 43 departments responded to the survey. Read More

Eur Arch Otorhinolaryngol 2019 Mar 19. Epub 2019 Mar 19.

Department of Otology and Skull Base Surgery, Hearing Research Key Lab of Health Ministry of China, Eye & Ear Nose and Throat Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.

HNO 2019 Mar 19. Epub 2019 Mar 19.

Institut für Neuroradiologie, HELIOS-Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125, Berlin, Deutschland.

Epistaxis is a common ear, nose, and throat emergency, but rarely a direct cause for hospital admission. Patients who receive inpatient treatment usually suffer from recurrent posterior epistaxis. Despite otolaryngologic measures such as posterior packing or surgery, bleeding may recur or continue or the source may not be surgically accessible. Read More

Ear Nose Throat J 2019 Mar 19:145561319839504. Epub 2019 Mar 19.

3 Section of Otolaryngology, Yale New Haven Hospital-St. Raphael Campus and the Yale University School of Medicine, New Haven, CT, USA.

BMC Rheumatol 2018 10;2:37. Epub 2018 Dec 10.

4Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Background: Autoimmune disorders are known to produce false positives in serological tests for infections. Aetiological association between infections and autoimmunity, increased susceptibility to infectious and autoimmune disorders with immune dysregulation and non-specific polyclonal expansion of B cells with autoimmunity may cause confusion in diagnosis and patient management. We report a patient with Adult Onset Still's Disease (AOSD) presenting with rising melioidosis antibody titres that caused diagnostic confusion. Read More

Heliyon 2019 Feb 25;5(2):e01273. Epub 2019 Feb 25.

Chevron ETC, Houston, TX, USA.

The geometry of converging-diverging nozzles affects the conditions at which critical-subcritical flow transition occurs. The objective of this work is to develop guidelines to identify the optimum nozzle geometry that maximizes critical pressure ratio while minimizing pressure drop across the nozzle. Experiments were conducted in a facility with 1. Read More

Antimicrob Resist Infect Control 2019 6;8:49. Epub 2019 Mar 6.

2Center for Healthcare Organization and Implementation Research (CHOIR), VA Boston, Healthcare System, 150 South Huntington Avenue, Boston, MA 02130 USA.

Background: Guidelines recommend discontinuation of antimicrobial prophylaxis within 24 h after incision closure in uninfected patients. However, how facility and surgical specialty factors affect the implementation of these evidence-based surgical prophylaxis guidelines in outpatient surgery is unknown. Thus, we sought to measure how facility complexity, including ambulatory surgical center (ASC) status and availability of ancillary services, impact adherence to guidelines for timely discontinuation of antimicrobial prophylaxis after outpatient surgery. Read More

Am J Otolaryngol 2018 Nov 22. Epub 2018 Nov 22.

Department of Otolaryngology, Head and Neck Surgery, Affiliated Eye, Ear, Nose and Throat Hospital, Fudan University, No. 83, Fenyang Road, 200031 Shanghai, China. Electronic address:

Objective: Juvenile nasopharyngeal angiofibroma (JNA) is non-metastasizing but potentially locally destructive tumor of the nasopharynx. It can destroy the skull base and invade into the cerebrum. Surgical management is the primary standard but residual disease is always a risk factor. Read More

Ear Nose Throat J 2019 Feb 15;98(2):79-80. Epub 2019 Feb 15.

1 Department of Otolaryngology & Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.

Ear Nose Throat J 2019 Feb 7;98(2):81-84. Epub 2019 Feb 7.

3 Department of Otolaryngology-Head and Neck Surgery, West Virginia University, Morgantown, WV, USA.

The "Clinical Practice Guideline: Tympanostomy Tubes in Children" published in 2013 by the American Academy of Otolaryngology-Head and Neck Surgery Foundation encourages that an "educational video, or other teaching aid, should be developed to illustrate how parents/caregivers" may manage postoperative complications such as tube otorrhea; however, the current literature is devoid of such patient safety and quality improvement measures. Our objective was to develop an effective educational model to assist parents and caregivers in understanding the signs and symptoms of tympanostomy tube (TT) otorrhea and how to independently institute the appropriate otologic treatment. A 3. Read More

Ear Nose Throat J 2019 Feb 28;98(2):68-69. Epub 2019 Jan 28.

1 Division of Otolaryngology, Department of Surgery-Head and Neck Surgery, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.

Ear Nose Throat J 2019 Feb 13;98(2):74-75. Epub 2019 Feb 13.

1 Department of Otolaryngology-Head and Neck Surgery, State University of New York at Buffalo, Buffalo, NY, USA.

Ear Nose Throat J 2019 Feb 31;98(2):64-65. Epub 2019 Jan 31.

2 Department of Otorhinolaryngology-Head and Neck Surgery, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan, Republic of China.

Ear Nose Throat J 2019 Feb 4;98(2):70-71. Epub 2019 Feb 4.

1 Department of Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine, Philadelphia, PA, USA.

Ear Nose Throat J 2019 Feb 13;98(2):76-77. Epub 2019 Feb 13.

2 Department of Otolaryngology, The Ohio State University, Columbus, OH, USA.

Ear Nose Throat J 2019 Feb 5;98(2):98-101. Epub 2019 Feb 5.

1 Department of Otolaryngology, King Saud University Medical City, Riyadh, Saudi Arabia.

The diagnosis of subglottic stenosis (SGS) is usually made by clinical assessment and definitively by a direct endoscopic examination. This study aimed to evaluate different spirometric values in relation to anatomical grading and severity of subglottic stenosis cases of upper airway obstruction. Cases of SGS that underwent dilatational procedures endoscopically at the otolaryngology department of the King Saud University Medical City, Riyadh, Saudi Arabia, from June 2015 to October 2017 were collected. Read More

Ear Nose Throat J 2019 Feb 31;98(2):66-67. Epub 2019 Jan 31.

1 Department of Otolaryngology, Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Chonbuk, Korea.

Ear Nose Throat J 2019 Feb 31;98(2):78. Epub 2019 Jan 31.

2 Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Ear Nose Throat J 2019 Feb 12;98(2):85-88. Epub 2019 Feb 12.

1 Department of Otolaryngology-Head and Neck Surgery, Glasgow Royal Infirmary, Glasgow, United Kingdom.

Background:: Endoscopic sphenopalatine artery ligation (ESPAL) is the intervention of choice for refractory epistaxis in specialist ear, nose and throat (ENT)units and should be within the repertoire of competencies for all ENT trainees. Following its recent incorporation within the United Kingdom competency-based training syllabus as an explicit outcome standard, the ESPAL is not uncommonly being delivered by trainees under appropriate supervision. We assessed the efficacy and outcome of ESPAL in epistaxis management within our teaching hospitals. Read More

Ear Nose Throat J 2019 Feb 13;98(2):102-106. Epub 2019 Feb 13.

1 Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, PA, USA.

Background:: Melanotic schwannoma is a rare tumor with indeterminate biologic behavior and varying treatment recommendations.

Methods:: We report 2 cases of pigmented melanotic schwannoma of the head and neck and perform literature review. The pathologic and immunohistochemical characteristics of melanotic schwannoma are reviewed. Read More

Ear Nose Throat J 2019 Feb 7;98(2):89-93. Epub 2019 Feb 7.

1 Ear Nose and Throat Department and Cystic Fibrosis Centre, Intercommunal Hospital of Créteil, Paris, France.

Background:: There is a medial bulging of the lateral nasal wall in patients with cystic fibrosis (CF).

Aims:: Uncinate process (UP) angulation measurements in patients and controls to objectify this bulging.

Materials And Methods:: Thirty CF, 17 primary ciliary dyskinesia (PCD), 13 chronic rhinosinusitis with polyps (CRSwp), and 30 controls were included. Read More

Ear Nose Throat J 2019 Feb;98(2):63

1 Department of Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine, Philadelphia, PA, USA.

Integr Med (Encinitas) 2017 Aug;16(4):32-41

All are located at Maryland University of Integrative Health in Laurel, Maryland.

This article series provides a literature review of the disease-specific probiotic strains associated with dermatological disorders and conditions that have been studied in published clinical trials in humans and animals. This is not an exhaustive review. The table design allows for quick access to supportive data and will be helpful as a guide for both researchers and clinicians. Read More

Integr Med (Encinitas) 2017 Jun;16(3):28-40

Maryland University of Integrative Health in Laurel, Maryland.

This article series provides a literature review of the disease-specific probiotic strains studied in published clinical trials in humans and animals. The goal of the series is to provide clinically useful tools. The table design allows for quick access to supportive data and will be helpful as a guide for both researchers and clinicians. Read More

Integr Med (Encinitas) 2017 Apr;16(2):28-38

All are located at Maryland University of Integrative Health in Laurel, Maryland.

This article series provides a literature review of the disease-specific probiotic strains studied in published clinical trials in humans and animals. The goal of the series is to provide clinically useful tools. The table design allows for quick access to supportive data and will be helpful as a guide for both researchers and clinicians. Read More

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2019 Jan;37(1):46-49

Shunyi District of Beijing Center for Disease Prevention and Control, Beijing 101300, China.

To investigate the incidence of occupational diseases in a District of Beijing, from 2004 to 2017 and to analyze the distribution characteristics and incidence trends of occupational diseases. The data of confirmed occupational disease cases data in the occupational disease and occupational health information monitoring system in a district of Beijing from 2004~2017 were collected to analyze the incidence and trends of occupational diseases. In 2004~2017, a total of 161cases of occupational diseases were reported in a district of Beijing, mainly pneumoconiosis (113 cases, 70. Read More

Curr Opin Ophthalmol 2019 Mar 14. Epub 2019 Mar 14.

Department of Ophthalmology and Visual Sciences, WK Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan.

Purpose Of Review: Approximately 10% of patients become blind despite using evidence-based guidelines developed from clinical trials and epidemiology studies. Our purpose is to review opportunities to decrease glaucoma-related blindness using the emerging principles of precision medicine.

Recent Findings: The current review focuses on three topics: first, candidate biomarkers for angle-based surgeries, second, head-mounted display (HMD) technology for vision and testing, and third, glaucoma risk alleles discovered by genome-wide association studies. Read More

Anesth Prog 2019 ;66(1):30-32

Department of Dental Anesthesiology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.

Hereditary angioedema (HAE) is a rare genetic disease that results from deficiency or dysfunction of C1 inhibitor (C1-INH). This disease is characterized by sudden attacks of angioedema. When edema occurs in the pharynx or larynx, it can lead to serious airway compromise, including death. Read More

Medicine (Baltimore) 2019 Mar;98(11):e14836

Department of Ophthalmology, The Second Xiangya Hospital.

Rationale: Extranodal natural killer T-cell lymphoma nasal type (ENKL) is an extremely rare tumor with a very low survival rate. In recent decades, only a few ENKL cases have been published. Presenting a special ENKL case lead the authors to emphasize the primary features of ENKL in early diagnosis and therapy. Read More

Ophthalmic Plast Reconstr Surg 2019 Mar 12. Epub 2019 Mar 12.

Department of Ophthalmology, New York University Langone Medical Center, New York, New York.

Purpose: To investigate the safety and efficacy of direct, intralesional doxycycline hyclate injection for improving the appearance of cosmetically significant lower eyelid festoons and malar edema.

Methods: An Institutional Review Board approved, retrospective review was performed of 15 consecutive patients with malar edema and/or festoons injected with doxycycline hyclate at a concentration of 10 mg/ml. Pre- and postinjection photographs were reviewed and graded on a scale of 0 to 3 (0: no festoon; 1: small festoon; 2: medium festoon; 3: large festoon) by 2 masked physician observers. Read More

Ear Hear 2019 Mar 14. Epub 2019 Mar 14.

Department of Head and Neck Surgery, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.

Objectives: While fundamental frequency (F0) cues are important to both lexical tone perception and multitalker segregation, F0 cues are poorly perceived by cochlear implant (CI) users. Adding low-frequency acoustic hearing via a hearing aid in the contralateral ear may improve CI users' F0 perception. For English-speaking CI users, contralateral acoustic hearing has been shown to improve perception of target speech in noise and in competing talkers. Read More

Acta Otolaryngol 2019 Mar 18:1-5. Epub 2019 Mar 18.

a NHC Key Laboratory of Hearing Medicine , Fudan University , Shanghai , PR China.

Background: Although, the diagnostic criteria for enlarged vestibular aqueduct syndrome (EVAS) were determined by years. On the shoulders of predecessors, we still detected some new discoveries about EVAS by using 3D-real IR MRI.

Aims/objectives: To analyze the signal intensity of membranous and osseous labyrinths of vestibular aqueduct (VA) and endolymphatic sac (ES) in EVAS using three-dimensional real inversion recovery (3D-Real-IR) magnetic resonance imaging (MRI) after intratympanic injection of gadolinium. Read More

Open Forum Infect Dis 2019 Mar 6;6(3):ofz048. Epub 2019 Feb 6.

Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao P.D.R.

Background: Japanese encephalitis virus (JEV) is a leading cause of central nervous system (CNS) infections in Asia and results in significant morbidity and mortality. JEV RNA is rarely detected in serum or cerebrospinal fluid (CSF), and diagnosis of JEV infection is usually based on serological tests that are frequently difficult to interpret. Unlike serum or CSF, urine is relatively easy to obtain, but, to date, there has been minimal work on the feasibility of testing urine for JEV RNA. Read More

Anesth Pain Med 2019 Feb 18;9(1):e57864. Epub 2019 Feb 18.

Department of Anesthesiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Nowadays, endoscopic sinus surgery is one of the most common surgeries in the field of ear, nose, and throat. This surgery has always been followed by bleeding and can cause hemodynamic disorders due to the direct effect of the endoscopic sinus surgery.

Objectives: This study aimed to investigate the hemodynamic changes with different doses of isoflurane during endoscopic sinus surgery. Read More

Plast Reconstr Surg Glob Open 2018 Nov 19;6(11):e2008. Epub 2018 Nov 19.

Department of Plastic and Reconstructive Surgery, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Reconstruction of total circumferential pharyngeal defects following caustic or stenosant lesions of the pharynx present major challenges with respect to minimizing surgical morbidity and restoring functional deficits. With recent advances in microvascular free tissue transfer, the options for pharyngeal reconstruction have multiplied in order to maximize swallowing and voice. There is long experience in the reconstruction of the pharynx and the cervical esophagus in oncological patients after total pharyngolaryngectomy, but there are not many publications concerning circumferential pharyngeal reconstruction preserving the larynx. Read More

Ther Clin Risk Manag 2019 25;15:309-313. Epub 2019 Feb 25.

ENT Department, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania,

Background: The rigid tube for laryngoscopy is an instrument used in ENT, for inspecting the larynx and its vicinity. We used it to facilitate intubation, in ENT patients.

Methods: Twenty patients attending for surgery were included for study. Read More

Auris Nasus Larynx 2019 Mar 14. Epub 2019 Mar 14.

Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Ultrasonics 2019 Mar 6;95:45-51. Epub 2019 Mar 6.

Key Laboratory of Modern Acoustics, MOE, School of Physics, Nanjing University, Nanjing 210093, PR China.

Traditional acoustic regulations in practice are used to have major obstacles in low frequency range, for which absorbers or suppressors have thicknesses that are comparable to their working wavelength. We present an acoustic structure-based "coiling-up space" to achieve outstanding sound regulation of acoustic waves in the extremely low frequency region. The structure is composed of an open waveguide and with a spiral throat tube and a cavity. Read More

Int J Pediatr Otorhinolaryngol 2019 Mar 9;121:95-98. Epub 2019 Mar 9.

Aksaray University Faculty of Medicine, Department of Ear Nose and Throat and Head and Neck Surgery, Turkey. Electronic address:

Objective: The timing of tympanoplasty in the pediatric age group is an ongoing debate. The purpose of this study was to analyze and compare the success of grafts in type 1 tympanoplasty in pediatric patients, and to evaluate the prognostic factors that may affect its success.

Materials And Methods: A retrospective study of 42 pediatric patients who were younger than 18 years and underwent a primary type 1 tympanoplasty using tragal cartilage perichondrium and temporalis fascia from January 2013 to December 2018, were evaluated. Read More