397,239 results match your criteria Thoracic Spine Trauma

Establishing paediatric diagnostic reference levels using reference curves - A feasibility study including conventional and CT examinations.

Phys Med 2021 Jun 9;87:65-72. Epub 2021 Jun 9.

Department of Radiation Protection and Measurement Services, Norwegian Radiation and Nuclear Safety Authority, Bærum, Norway; Department of Health Sciences, Norwegian University of Science and Technology, Gjøvik, Norway.

Purpose: To derive Regional Diagnostic Reference Levels (RDRL) for paediatric conventional and CT examinations using weight-based DRL curves and compare the outcome with DRL derived using the weight groups.

Methods: Data from 1722 examinations performed at 29 hospitals in four countries were included. DRL was derived for four conventional x-ray (chest, abdomen, pelvis, hips/joints) and two types of CT examinations (thorax, abdomen). Read More

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Individuals with recurrent low back pain exhibit further altered frontal plane trunk control in remission than when in pain.

Clin Biomech (Bristol, Avon) 2021 May 28;87:105391. Epub 2021 May 28.

Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA.

Background: Movement alterations due to low back pain (LBP) could lead to long-term adverse consequences if they do not resolve after symptoms subside. This study aims to determine if altered trunk control associated with recurrent low back pain persists beyond symptom duration.

Methods: Twenty young adults with recurrent LBP were tested once during an LBP episode and once in symptom remission, and twenty matched back-healthy participants served as controls. Read More

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Dexamethasone reduces the formation of thoracic aortic aneurysm and dissection in a murine model.

Exp Cell Res 2021 Jun 10:112703. Epub 2021 Jun 10.

Department of Vascular Surgery, Peking University People's Hospital, Beijing, People's Republic of China. Electronic address:

Thoracic aortic aneurysm and dissection (TAAD) is a life-threatening vascular disease with no effective pharmaceutical therapies currently available. Inflammation plays a key role in the progression of aneurysms. Dexamethasone (DEX), a synthetic glucocorticoid, has showed alleviating effects on cells in vitro from TAAD patients. Read More

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Pralsetinib for RET fusion-positive non-small-cell lung cancer (ARROW): a multi-cohort, open-label, phase 1/2 study.

Lancet Oncol 2021 Jun 9. Epub 2021 Jun 9.

Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Oncogenic alterations in RET have been identified in multiple tumour types, including 1-2% of non-small-cell lung cancers (NSCLCs). We aimed to assess the safety, tolerability, and antitumour activity of pralsetinib, a highly potent, oral, selective RET inhibitor, in patients with RET fusion-positive NSCLC.

Methods: ARROW is a multi-cohort, open-label, phase 1/2 study done at 71 sites (community and academic cancer centres) in 13 countries (Belgium, China, France, Germany, Hong Kong, Italy, Netherlands, Singapore, South Korea, Spain, Taiwan, the UK, and the USA). Read More

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The land of the Lotus-eaters in the COVID-19 epidemic.

Eur J Cardiothorac Surg 2021 Jun 12. Epub 2021 Jun 12.

Department of Thoracic Surgery, IEO, European Institute of Oncology IRCCS, Milan, Italy.

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Perioperative platelet reduction after sutureless or stented valve implantation: results from the PERSIST-AVR controlled randomized trial.

Eur J Cardiothorac Surg 2021 Jun 12. Epub 2021 Jun 12.

Klinikum Nürnberg, Cardiovascular Center, Paracelsus Medical University, Nuremberg, Germany.

Objectives: Platelet count reduction is a common but not fully understood phenomenon after aortic valve replacement (AVR) with bioprosthesis implantation. The aim of the present study was to investigate the occurrence and the clinical impact of platelet count reduction in patients receiving the Perceval bioprosthesis compared to those receiving standard sutured stented bioprosthetic aortic valve in a randomized, controlled AVR study.

Methods: PERceval Sutureless Implant versus STandard Aortic Valve Replacement is a prospective, randomized, adaptive, open-label trial. Read More

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Aortic Angiosarcoma in Association with Endovascular Aneurysm Repair: Case Report and Review of the Literature.

Am J Case Rep 2021 Jun 12;22:e931740. Epub 2021 Jun 12.

Division of Clinical Pathology, Niigata University Faculty of Medicine, Niigata, Japan.

BACKGROUND Primary aortic sarcoma often poses diagnostic challenges for pathologists and clinicians because of a very low incidence and controversy over nomenclature and definition. We report a case of aortic angiosarcoma in association with a graft. We also conducted a clinicopathological review of cases of primary aortic sarcomas associated with implanted grafts. Read More

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MiR-124 protects against cognitive dysfunction induced by sevoflurane anesthesia in vivo and in vitro through targeting calpain small subunit 1 via NF-κB signaling pathway.

Adv Clin Exp Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Anesthesiology, The Third Hospital of Hebei Medical University, Shijiazhuang, China.

Background: Postoperative cognitive dysfunction (POCD) is an impairment of cognition that affects post-surgery patients. Sevoflurane anesthesia is linked to cognitive dysfunction correlated to the expression of miRNA levels.

Objectives: In the current study, we investigated if miR-124 can offer protection against cognitive deficits induced by sevoflurane in a spatial learning paradigm, and examined the molecular mechanisms through cell cultures. Read More

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Letermovir in lung transplant recipients with cytomegalovirus infection: A retrospective observational study.

Am J Transplant 2021 Jun 12. Epub 2021 Jun 12.

Department of Internal Medicine V, University Hospital, LMU, Comprehensive Pneumology Center (CPC-M), German Center for Lung Research (DZL), Germany.

Letermovir is a new antiviral drug approved for the prophylaxis of CMV infection in allogeneic stem cell transplants. The aim of the study was to assess the therapeutic efficacy of letermovir in difficult to treat CMV infections in lung transplant recipients. All lung transplant recipients between March 2018 and August 2020, who have been treated with letermovir for ganciclovir-resistant or refractory CMV infection were included in the study and analysed retrospectively. Read More

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Cardiac surgeons' concerns, perceptions, and responses during the COVID-19 pandemic.

J Card Surg 2021 Jun 12. Epub 2021 Jun 12.

Division of Cardiothoracic Surgery, UC Davis Medical Center, Sacramento, California, USA.

Background: The coronavirus disease 2019 (COVID-19) pandemic has had an unprecedented impact on health care and cardiac surgery. We report cardiac surgeons' concerns, perceptions, and responses during the COVID-19 pandemic.

Methods: A detailed survey was sent to recruit participating adult cardiac surgery centers in North America. Read More

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Inflammatory disease of the costotransverse joints: US evaluation in 15 symptomatic patients.

J Ultrasound 2021 Jun 12. Epub 2021 Jun 12.

Advanced Musculoskeletal Ultrasound, SIUMB School of Pisa, Pisa, Italy.

The costotransverse joints (CTJs) are small arthrodial joints which articulate with the costal tuberosity on the transverse process of the thoracic vertebrae. CTJs are composed of oval-shaped facets with a major axis, vertical at the upper vertebrae and almost horizontal at the lower vertebrae. This position explains the different movements of the ribs: the cranial ribs move on the sagittal plane and the caudal ribs on the transverse plane. Read More

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Endoplasmic reticulum stress in the acute intestinal epithelial injury of necrotizing enterocolitis.

Pediatr Surg Int 2021 Jun 12. Epub 2021 Jun 12.

Division of General and Thoracic Surgery, The Hospital for Sick Children, University of Toronto, 1526-555 University Ave, Toronto, ON, M5G 1X8, Canada.

Endoplasmic reticulum (ER) is a dynamic organelle that has many functions including protein synthesis, lipid synthesis, and calcium metabolism. Any perturbation in the ER such as accumulation of unfolded or misfolded proteins in the ER lumen causes ER stress. ER stress has been implicated in many intestinal inflammatory diseases. Read More

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Incidence, predictors and clinical impact of permanent pacemaker insertion in women following transcatheter aortic valve implantation: Insights from a prospective multinational registry.

Catheter Cardiovasc Interv 2021 Jun 12. Epub 2021 Jun 12.

The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Objectives: To describe the incidence, predictors, and clinical impact of permanent pacemaker insertion (PPI) following transcatheter aortic valve replacement (TAVR) in women.

Background: Data on pacemaker insertion complicating TAVR in women are scarce.

Methods: The Women's International Transcatheter Aortic Valve implantation (WIN-TAVI) is a prospective registry evaluating the safety and efficacy of TAVR in women. Read More

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MiR-133a-3p inhibits the malignant progression of esophageal cancer by targeting CDCA8.

J Biochem 2021 Jun 12. Epub 2021 Jun 12.

Department of Thoracic Surgery, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou City, Fujian Province, 350001, China.

Objective: To explore the interaction between miR-133a-3p and CDCA8 in esophageal cancer (EC) and their effect on malignant behavior of EC cells.

Methods: Differential miRNAs and mRNAs were obtained from The Cancer Genome Atlas (TCGA) database. Quantitative real-time PCR (qRT-PCR) was used to detect the expression levels of miR-133a-3p and CDCA8 mRNA in EC cells. Read More

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Indocyanine green is a sensitive adjunct in the identification and surgical management of local and metastatic hepatoblastoma.

Cancer Med 2021 Jun 12. Epub 2021 Jun 12.

Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Background: Hepatoblastoma is the most common primary pediatric liver malignancy. Indocyanine green (ICG) has been described as an adjunct to resection in small series. Its utility remains undefined in larger cohorts. Read More

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The increased expression and aberrant methylation of SHC1 in non-small cell lung cancer: Integrative analysis of clinical and bioinformatics databases.

J Cell Mol Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Despite the previous evidence showing that SHC adaptor protein 1 (SHC1) could encode three distinct isoforms (p46SHC, p52SHC and p66SHC) that function in different activities such as regulating life span and Ras activation, the precise underlying role of SHC1 in lung cancer also remains obscure. In this study, we firstly found that SHC1 expression was up-regulated both in lung adenocarcinoma (LUAD) and in lung squamous cell carcinoma (LUSC) tissues. Furthermore, compared to patients with lower SHC1 expression, LUAD patients with higher expression of SHC1 had poorer overall survival (OS). Read More

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Pediatric rib pathologies: clinicoimaging scenarios and approach to diagnosis.

Pediatr Radiol 2021 Jun 12. Epub 2021 Jun 12.

Radiology Department, Seattle Children's Hospital, University of Washington Medical Center, 4800 Sand Point Way NE, Seattle, WA, 98105, USA.

Pathologies involving the ribs are diverse in nature, including entities specific to the pediatric population as well as shared pathologies with adults. These can be either localized within or adjacent to the rib, but may also cause rib alteration as a component of a systemic process. To better understand these disorders, we discuss several common rib pathologies in the context of their clinical presentation and pertinent imaging findings. Read More

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Survival Comparison Between Open and Thoracoscopic Upfront Esophagectomy in Patients with Esophageal Squamous Cell Carcinoma.

Ann Surg 2021 Jun 10. Epub 2021 Jun 10.

Division of Thoracic Surgery, Department of Surgery, Changhua Christian Hospital, Taiwan School of Medicine, Chung Shan Medical University, Taichung, Taiwan School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung, Taiwan Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan Center for General Education, Ming Dao University, Changhua, Taiwan Division of Chest Medicine, Department of Internal Medicine, Changhua Christian Hospital, Taiwan Institute of Health and Welfare Policy, National Yang Ming Chiao Tung University, Taipei, Taiwan Department of Health Care Administration, Chang Jung Christian University.

Background: The survival outcomes of patients with esophageal squamous cell carcinoma (ESCC) after open or thoracoscopic upfront esophagectomy remained unclear.

Objective: The aim of this retrospective study was to compare overall survival between open and thoracoscopic esophagectomy for ESCC patients without neoadjuvant CRT.

Methods: The Taiwan Cancer Registry was investigated for ESCC cases from 2008-2016. Read More

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Statin therapy for patients with aortic stenosis who underwent transcatheter aortic valve implantation: a report from a Japanese multicentre registry.

BMJ Open 2021 Jun 11;11(6):e044319. Epub 2021 Jun 11.

Department of Cardiology, Keio University School of Medicine, Shinjuku-ku, Japan.

Objective: Data on statin for patients with aortic stenosis (AS) who underwent transcatheter aortic valve implantation (TAVI) are limited. The present study aimed to evaluate the impact of statin on midterm mortality of TAVI patients.

Design: Observational study. Read More

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Oesophageal rupture from a pneumatic blast injury: an unusual mechanism of blunt oesophageal trauma.

BMJ Case Rep 2021 Jun 11;14(6). Epub 2021 Jun 11.

Division of Trauma and Acute Care Surgery, Unity Health Toronto, Toronto, Ontario, Canada

Oesophageal perforation is a serious condition associated with significant morbidity and mortality. Clinical suspicion of oesophageal injury in patients sustaining neck or torso trauma is essential as early diagnosis and management are associated with better outcomes. Oesophageal perforation resulting from blunt trauma is uncommon, and traumatic oesophageal perforation following blast injury is exceedingly rare. Read More

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Abdominal flank bulge following intercostal neurectomy for symptomatic rib fracture nonunion.

BMJ Case Rep 2021 Jun 11;14(6). Epub 2021 Jun 11.

Trauma Research Unit, Department of Surgery, Erasmus MC, University Medical Center, Rotterdam, Zuid-Holland, The Netherlands.

The gold standard for rib fracture nonunion management remains a matter of debate. Operative treatment of rib fracture nonunion has become increasingly popular. A 69-year-old man was operatively treated with intercostal neurectomy of the left eighth rib to resolve chronic thoracic pain following a rib fracture nonunion. Read More

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Extensive right-sided infectious endocarditis due to .

BMJ Case Rep 2021 Jun 11;14(6). Epub 2021 Jun 11.

Cardiology, Centro Hospitalar do Médio Ave EPE, Vila Nova de Famalicão, Portugal.

is a rare cause of infectious endocarditis. Most cases have an acute and aggressive evolution, with a high mortality rate. We report the case of a 36-year-old man, with a history of unrepaired ventricular septal defect, who came to the emergency department with fever, cough and asthenia with 3 months of evolution. Read More

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Structural abnormalities after aortic root replacement with stentless xenograft.

J Thorac Cardiovasc Surg 2021 May 12. Epub 2021 May 12.

Department of Cardiothoracic Surgery, The Heart Center, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.

Objective: In complex and high-risk aortic root disease, the porcine Freestyle stentless bioprosthesis (Medtronic Inc, Minneapolis, Minn) is an important surgical treatment option. We aimed to determine prevalence and clinical effect of structural and functional abnormalities after full-root Freestyle implantation.

Methods: Our cross-sectional 2-center study combined with clinical follow-up included 253 patients with full-root Freestyle bioprostheses implanted from 1999 to 2017. Read More

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Infrared thermography for assessment of thoracic paravertebral block: a prospective observational study.

BMC Anesthesiol 2021 Jun 11;21(1):168. Epub 2021 Jun 11.

Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: There was no "gold standard" to assess the success or failure of thoracic paravertebral block (TPVB). Measurement of skin temperature with infrared thermography (IT) would be a reliable method to evaluate the effectiveness of regional blocks. This study aimed to explore the feasibility of using skin temperature difference (Td) determined by IT between the blocked and unblocked side to predict the spread of TPVB. Read More

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[Modern Treatment Options for Postoperative Chylothorax: a Systematic Review].

Pneumologie 2021 Jun 11;75(6):439-446. Epub 2021 Jun 11.

Klinik für Thoraxchirurgie, Regiomed Kliniken GmbH, Sonneberg/Coburg.

Background:  Chylothorax is a multifactorial complication, usually caused by surgery or traumatic injury, and more rarely by malignant disease. Because of the lack of prospective, randomised trials, the evidence-based treatment rests upon personal experience, but ideally taking into account retrospective analysis.

Material And Methods:  The aim of this review is to provide a comprehensive overview of the currently available modern treatment options. Read More

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Clinical management of patients with thymic epithelial tumors: the recommendations endorsed by the Italian Association of Medical Oncology (AIOM).

ESMO Open 2021 Jun 8;6(4):100188. Epub 2021 Jun 8.

Division of Medical Oncology for Melanoma, Sarcoma, and Rare Tumors, Istituto Europeo di Oncologia, IRCCS, Milan, Italy.

The Italian Association of Medical Oncology recommendations on thymic epithelial tumors, which have been drawn up for the first time in 2020 through an evidence-based approach, report indications on all the main aspects of clinical management of this group of rare diseases, from diagnosis and staging, to new available systemic treatments, such as targeted therapies and immunotherapies. A summary of key recommendations is presented here and complete recommendations are reported as Supplementary Materials, available at https://doi.org/10. Read More

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Management of a broken thoracic paravertebral catheter in a pediatric patient.

J Clin Anesth 2021 Jun 8;73:110361. Epub 2021 Jun 8.

UPMC Children's Hospital of Pittsburgh, Division of Pediatric General and Thoracic Surgery, 4401 Penn Avenue, Pittsburgh, PA 15224, USA.

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