339,753 results match your criteria Thoracic Discogenic Pain Syndrome


Lipomeningocele associated with diplomyelia in a dog.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):323-329. Epub 2018 Dec 12.

A 2-year-old male neutered mixed breed dog with a body weight of 30 kg was presented for evaluation of a soft subcutaneous mass on the dorsal midline at the level of the caudal thoracic spine. A further clinical sign was intermittent pain on palpation of the area of the subcutaneous mass. The owner also described a prolonged phase of urination with repeated interruption and re-initiation of voiding. Read More

View Article
October 2018
4 Reads

Honesty.

Thorac Cardiovasc Surg 2018 Nov 12;66(8):607. Epub 2018 Dec 12.

Department of Cardiac, Thoracic and Vascular Surgery, Universitaetsmedizin Mainz, Mainz, Germany.

View Article
November 2018

A population-based cohort study to evaluate the effectiveness of lung cancer screening using low-dose CT in Hitachi city, Japan.

Jpn J Clin Oncol 2018 Dec 12. Epub 2018 Dec 12.

Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan.

Objectives: To evaluate the effectiveness of lung cancer screening using low-dose computed tomography for the general population, we conducted a retrospective cohort study of screening for participants among Hitachi residents.

Materials And Methods: Citizens aged 50-74 who underwent low-dose computed tomography screening at least once during 1998-2006 were defined as the computed tomography group, and those who underwent X-ray screening at least once during the same period, but did not receive low-dose computed tomography screening throughout the follow-up period, were defined as the XP group. We investigated the lung cancer incidence rate, mortality rate and all-cause mortality rate for both groups from the first lung cancer screening to the end of 2012. Read More

View Article
December 2018

Postimplant biological aortic prosthesis degeneration: challenges in transcatheter valve implants.

Eur J Cardiothorac Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardio-Thoracic Surgery, Maastricht University Medical Centre, Maastricht, Netherlands.

Surgical aortic valve replacement (SAVR) is highly effective and can be achieved with relatively low risk in patients with severe aortic stenosis. Bioprostheses have been used most frequently during the past 60 years. However, the function of biological valves usually declines after 10-15 years from implant when structural valve degeneration occurs often mandating a reoperation once valve dysfunction becomes haemodynamically significant. Read More

View Article
December 2018

Extracorporeal immunoadsorption in heparin- and protamine-induced thrombocytopaenia prior to cardiac surgery.

Eur J Cardiothorac Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Division of Cardiac Thoracic Vascular Anaesthesia and Intensive Care Medicine, Medical University of Vienna, Vienna, Austria.

Exposure to heparin and protamine during cardiac surgery on cardiopulmonary bypass (CPB) may trigger heparin-induced thrombocytopaenia and/or protamine-induced thrombocytopaenia. Further surgery on CPB with heparin and protamine in the presence of these antibodies implies increased thromboembolic risk. We present the successful application of extracorporeal immunoadsorption to deplete antibodies causing heparin-induced and protamine-induced thrombocytopaenia preoperatively. Read More

View Article
December 2018

Let's Call It Lung Shock - Or Do We Use the Right Wording?

Respiration 2018 Dec 12:1-2. Epub 2018 Dec 12.

Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.

View Article
December 2018

Systemic involvement in ACS: Using CMR imaging to compare the aortic wall in patients with and without acute coronary syndrome.

PLoS One 2018 12;13(12):e0203514. Epub 2018 Dec 12.

Division of Cardiology, Institute for Cardiology and Cardiac Surgery, NewYork-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, United States of America.

Background/objectives: Previous studies have demonstrated that in acute coronary syndrome (ACS), plaque destabilization and vessel inflammation, represented by vessel edema, often occur simultaneously in multiple coronaries, as well as extend to the cerebrovascular system. Our aim was to determine whether the inflammatory vascular processes occurring within the coronaries during ACS extend simultaneously to the descending aorta.

Methods: We prospectively enrolled 111 patients (56 ACS patients and 55 non-ACS patients with known coronary artery disease) to undergo cardiac magnetic resonance of the thoracic aortic wall at presentation and at three-month follow-up. Read More

View Article
December 2018

Limited Sequence MRI's for Early Onset Scoliosis Patients Detected 100% of Neural Axis Abnormalities While Reducing MRI Time by 68.

Spine (Phila Pa 1976) 2018 Dec 11. Epub 2018 Dec 11.

Children's Orthopaedic Center, Children's Hospital Los Angeles.

Study Design: Diagnostic accuracy.

Objective: The purpose of this study was to determine if neural axis abnormalities in early onset scoliosis (EOS) patients can be reliably detected with limited magnetic resonance imaging (MRI) sequences (sagittal T1, sagittal T2).

Summary Of Background Data: MRI's are often performed in EOS patients as studies have shown there are neural axis abnormalities in up to 40% of this population. Read More

View Article
December 2018

Use of tracheal ultrasound combined with clinical parameters to select left double-lumen tube size: A prospective observational study.

Eur J Anaesthesiol 2018 Dec 11. Epub 2018 Dec 11.

From the Department of Anesthesiology and Intensive Care, C.H.U. Dijon (ER, PI, P-GG, BB, OD-R), Dijon and Université Bourgogne Franche-Comté, LNC UMR866, Dijon Cedex, France (P-GG, BB, OD-R), Anaesthesia and Intensive Care, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, Italy (SM, FM) and Unit of Anaesthesia and Intensive Care, Department of Clinical-Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy (ER, FM).

Background: Left double-lumen tubes (LDLTs) are used in thoracic surgery to allow one-lung ventilation. Their size is usually chosen on the basis of clinical parameters (height, sex). Double-lumen endobronchial tubes are frequently undersized/oversized, risking tube displacement or tracheal trauma. Read More

View Article
December 2018

Anticoagulation Management and Heparin Resistance During Cardiopulmonary Bypass: A Survey of Society of Cardiovascular Anesthesiologists Members.

Anesth Analg 2018 Dec 11. Epub 2018 Dec 11.

Department of Anesthesiology, Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.

We surveyed Society of Cardiovascular Anesthesiologists members regarding anticoagulation practices for cardiopulmonary bypass and attitudes on heparin resistance. Of 550 respondents (18.5% response rate), 74. Read More

View Article
December 2018

Reason and Timing for Conversion to Sternotomy in Robotic-Assisted Coronary Artery Bypass Grafting and Patient Outcomes.

Innovations (Phila) 2018 Dec 5. Epub 2018 Dec 5.

From the Divisions of Cardiac Surgery and.

Objective: Conversion to sternotomy is a primary bailout method for robotically assisted coronary artery bypass grafting procedures. The aims of this study were to identify the primary reasons for conversion from robotically assisted coronary artery bypass grafting to sternotomy and to evaluate the in-hospital outcomes in such patients.

Methods: Prospectively collected data from February 2004 to April 2017 were reviewed for 72 patients (56 men; mean age = 63. Read More

View Article
December 2018
1 Read

Precise anesthesia in thoracoscopic operations.

Curr Opin Anaesthesiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Anesthesiology.

Purpose Of Review: The current review focuses on precise anesthesia for video-assisted thoracoscopic surgery (VATS) with the goal of enhanced recovery.

Recent Findings: VATS has become an established and widely used minimally invasive approach with broad implementation on a variety of thoracic operations. In the current environment of enhanced recovery protocols and cost containment, minimally invasive VATS operations suggest adoption of individualized tailored, precise anesthesia. Read More

View Article
December 2018

[Spontaneous haemothorax - thoracic surgeon and intervention radiologist successful cooperation].

Magy Seb 2018 Dec;71(4):155-162

Mellkassebészeti Részleg, Mellkas- és Érsebészeti Osztály, Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Oktatókórház 3526, Miskolc, Szentpéteri kapu 72-76.

The definition of spontaneous haemothorax is accumulation of blood within the pleural space without trauma or iatrogenic causes. A case of a 17-year-old male patient with a history of multiple abnormal arterial fistulas between systemic circulation and pulmonary circulation as a cause of bleeding is presented. An overview of the causes, the clinical features of haemothorax and the interventional radiological methods that can solve some causes of haemothorax are presented in connection of our case report. Read More

View Article
December 2018

Clinical Characterization of Immunotherapy-Related Pruritus Among Patients Seen in 2 Oncodermatology Clinics.

JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

View Article
December 2018

Multiple intercostal neurilemmomas in a Chinese woman.

J Cancer Res Ther 2018 Dec;14(Supplement):S1220-S1222

Department of Respiratory and Critical Care Medicine, Jinling Hospital, Nanjing University Medical School, Nanjing, People's Republic of China.

Neurilemmomas are rare tumors of neural crest cell origin that occur most commonly in the head and neck region. Intercostal neurilemmomas are extremely rare and are mostly seen as solitary tumors in the posterior mediastinum. Only one case report of multiple intercostal neurilemmomas has been documented previously. Read More

View Article
December 2018

The prognostic role of thyroid transcription factor-1 in lung adenocarcinoma.

J Cancer Res Ther 2018 Dec;14(Supplement):S1201-S1208

Department of Medical Oncology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.

Aims: In this study, we investigated the expression of thyroid transcription factor-1 (TTF-1) in lung adenocarcinoma patients' samples and analyzed the association of TTF-1 with clinicopathological parameters, prognosis, and treatment options in patients with lung adenocarcinoma.

Subjects And Methods: This retrospective study enrolled 200 patients who were histologically confirmed lung adenocarcinoma with Stage I-IV disease, between 2008 and 2015 years. The cytological archive of these hospitals' Pathology Department was searched. Read More

View Article
December 2018

Impact of season of diagnosis on mortality among breast cancer survivors.

J Cancer Res Ther 2018 Dec;14(Supplement):S1091-S1097

Department of Thoracic Surgery and Oncology, National Cancer Institute, Santariskiu g. 1, LT-08660 Vilnius, Lithuania.

Introduction: There is mounting evidence that the time of breast cancer diagnosis and the start of treatment can improve survival rates. The aim of this study was to test the relationship between the season of breast cancer diagnosis and the survival of women patients receiving standard surgery treatment with radiotherapy.

Materials And Methods: The nonmetastatic breast cancer patients (n = 991) were followed from the date of diagnosis until death. Read More

View Article
December 2018

Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis.

Neural Regen Res 2019 Mar;14(3):532-541

Department of Orthopedics, Tianjin Medical University General Hospital; International Science and Technology Cooperation Base of Spinal Cord Injury; Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, China.

Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It has yet to be clarified whether ferroptosis inhibition represents the mechanism of action of Deferoxamine on spinal cord injury recovery. Read More

View Article

Risk of bleeding after ultrasound-guided jugular central venous catheter insertion in severely thrombocytopenic oncologic patients.

Am J Surg 2019 Jan 27;217(1):133-137. Epub 2018 Jun 27.

Department of Cardiovascular & Thoracic Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, United States; Department of Interventional Radiology, University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address:

Introduction: We sought to assess the incidence and risk factors of bleeding after ultrasound-guided internal jugular (USGIJ) catheter insertion in severely thrombocytopenic cancer patients, as safe platelet (PLT) count threshold remains controversial.

Methods: Retrospective study of 52 patients with hematologic malignancies and severe thrombocytopenia who underwent USGIJ catheter insertion between 2014 and 2016. Group A included patients with prophylactic PLT transfusion and Group B without. Read More

View Article
January 2019

The Incremental Value of Right Ventricular Size and Strain in the Risk Assessment of Right Heart Failure Post - Left Ventricular Assist Device Implantation.

J Card Fail 2018 Dec 26;24(12):823-832. Epub 2018 Oct 26.

Division of Cardiovascular Medicine, Stanford University School of Medicine and Stanford Cardiovascular Institute, Palo Alto, California.

Background: Right heart failure (RHF) after left ventricular assist device (LVAD) implantation is associated with high morbidity and mortality. Existing risk scores include semiquantitative evaluation of right ventricular (RV) dysfunction. This study aimed to determine whether quantitative evaluation of both RV size and function improve risk stratification for RHF after LVAD implantation beyond validated scores. Read More

View Article
December 2018

Isolated tension pneumoperitoneum following endobronchial ultrasound-guided transbronchial needle aspiration complicated by cardiac peri-arrest: A case report.

Monaldi Arch Chest Dis 2018 Dec 12;88(3):999. Epub 2018 Dec 12.

San Raffaele Scientific Institute, Department of Thoracic Surgery.

Transbronchial needle aspiration under endobronchial ultrasound guidance (EBUS-TBNA) is recommended for the diagnosis and staging of lung cancer. Major complications following EBUS-TBNA are uncommon. We report a case of isolated tension pneumoperitoneum following EBUS-TBNA under deep sedation in an 80-year-old male patient affected by a right hilar mass suspicious for lung cancer. Read More

View Article
December 2018

Detection of MicroRNA-Mediated Target mRNA Cleavage and 3'-Uridylation in Human Cells by a SLA-RT-PCR Analysis.

Authors:
Jing Lin Lin Ji

Methods Mol Biol 2019 ;1870:125-136

Department of Thoracic and Cardiovascular Surgery, Unit 1489, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

MicroRNA (miRNA) plays an important role in posttranscriptional regulation of gene expression by dominantly binding to the 3'-UTR regions of target mRNAs in the miRNA-induced silencing complex (miRISC), triggering off their sequential cleavage and 3'-uridylation, facilitating their degradation, repressing target gene expression, and leading to a reduced protein output. The miRNA-mediated target mRNA cleavage activity generates cleaved mRNA fragments with varied termini, which creates major technical challenges for the accurate and efficient detection and verification of cleavage sites on target mRNAs and the resulting mRNA fragments in transition. Here we described a sensitive stem-loop array reverse transcription polymerase chain reaction (SLA-RT-PCR) approach to detect and verify the miRNA-mediated target mRNA cleavage sites by determining precise sequences at the 3'- termini of cleaved mRNA fragments and their 3'-uridylation in human cells under physiological conditions. Read More

View Article
January 2019

Immune-Related Adverse Events: Pneumonitis.

Adv Exp Med Biol 2018 ;995:131-149

Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Checkpoint inhibitors are part of the family of immunotherapies and are increasingly being used in a wide variety of cancers. Immune-related adverse events pose a major challenge in the treatment of cancer patients. Pneumonitis is a rare immune-related adverse event that presents in distinct patterns. Read More

View Article
January 2018

Immunotherapy in Lung Cancer: A New Age in Cancer Treatment.

Adv Exp Med Biol 2018 ;995:65-95

Thoracic Oncology Program, University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.

The management of Non-Small Cell Lung Cancer (NSCLC) has changed dramatically in the last 10 years with an increase in the understanding of the biology and with the development of new and multiple treatments. Chemotherapy being the first systemic treatment used in the setting of advanced disease, proving benefit for patients over palliative care. With the identification of oncogenic drivers, innovative targeted therapies were developed and tested, leading to important changes in the management of certain patients and giving to some of them the possibility to be treated in first line with oral inhibitors. Read More

View Article
January 2018

Procurement and Storage of Pleural and Peritoneal Fluids for Biobanking.

Methods Mol Biol 2019 ;1897:125-133

Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA.

There is limited information regarding the biobanking of pleural and peritoneal fluids that might supplement storage of pulmonary and thoracic tissue biospecimens. Such fluids are sometimes collected for clinical analyses and may have uses that obviate or supplement tissue samples. There has been a growing interest in using liquid biopsies as they are less invasive and may be amenable to analyses that guide targeted therapies. Read More

View Article
January 2019

Antioxidant enzyme activity in responses to environmentally induced oxidative stress in the 5th instar nymphs of Aiolopus thalassinus (Orthoptera: Acrididae).

Environ Sci Pollut Res Int 2018 Dec 11. Epub 2018 Dec 11.

Department of Animal Physiology and Ecotoxicology, University of Silesia in Katowice, Katowice, Poland.

The response of antioxidant enzymes to oxidative environmental stress was determined in 5th instar nymphs of Aiolopus thalassinus (Orthoptera: Acrididae) collected from sites with different level of pollution with heavy metals, PO, and SO. The high polluted site induced higher DNA damage to individuals compared to the control site. The highest values of tail length (TL), tail moment (TM), and percent of DNA in tail (TDNA) were found in the gut of 5th instar nymphs from a high polluted site. Read More

View Article
December 2018

The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma.

J Mol Med (Berl) 2018 Dec 11. Epub 2018 Dec 11.

Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.

No tyrosine kinase inhibitors are approved for malignant pleural mesothelioma (MPM). Preclinical studies identified focal adhesion kinase (FAK) as a target in MPM. Accordingly, we assessed the novel, highly selective FAK inhibitor (BI 853520) in 2D and 3D cultures and in vivo. Read More

View Article
December 2018

Pilot evaluation of an objective structured assessment of technical skills tool for chest tube insertion.

GMS J Med Educ 2018 15;35(4):Doc48. Epub 2018 Nov 15.

University of Heidelberg, Department of General, Visceral, and Transplantation Surgery, Heidelberg, Germany.

Chest tube insertion is a standard intervention for management of various injuries of the thorax. Efficient clinical training of this and similar bed-side procedures is equally demanded and improvable. Here, we propose a nouveau means of assessment and feedback using an Objective Structured Assessment of Technical Skills (OSATS) tool. Read More

View Article
November 2018

Radiation recall myelitis following paclitaxel chemotherapy: The first reported case.

J Radiosurg SBRT 2018 ;5(4):331-334

Department of Radiation Medicine, Oregon Health and Science University, Portland, OR, USA.

Introduction: Stereotactic body radiotherapy (SBRT) of the spine has become an increasingly utilized modality in the United States, most commonly for metastatic disease (McClelland et al., 2017). Spinal SBRT in patients with spinal instrumentation has been sparsely examined. Read More

View Article
January 2018

Tuberculosis of the Thyroid Gland Presented as a Rapid Enlargement of a Preexisting Goiter.

Case Rep Endocrinol 2018 12;2018:4369531. Epub 2018 Nov 12.

Department of Endocrinology, La Rabta hospital, Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia.

Thyroid involvement with tuberculosis is an uncommon condition even in endemic countries. As its clinical presentation is not specific, diagnosis is often difficult and requires histopathological confirmation. Herein we report an observation of secondary tuberculosis of the thyroid gland in a woman with a type 2 diabetes mellitus and a primary hypothyroidism. Read More

View Article
November 2018

Predictive Value of Preoperative Volume-Based 18F-2-Fluoro-2-Deoxy-d-Glucose Positron Emission Tomography/Computed Tomography Parameters in Patients with Resectable Lung Adenocarcinoma.

Nucl Med Mol Imaging 2018 Dec 7;52(6):453-461. Epub 2018 Nov 7.

1Department of Nuclear Medicine, Korea University Anam Hospital, 73, Inchon-ro, Seongbuk-gu, Seoul, 02841 Republic of Korea.

Purpose: This study aimed to investigate the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG), which are volume-based PET parameters, using F-2-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (F-FDG PET/CT) in patients with surgically resectable lung adenocarcinoma.

Methods: We retrospectively evaluated 149 patients with lung adenocarcinoma who underwent F-FDG PET/CT before surgical resection. Maximum standardized uptake value (SUVmax), MTV, and TLG of the primary tumor with threshold value of SUVmax 30, 40, and 50% were calculated, respectively. Read More

View Article
December 2018

Resection of Liver Metastases: A Treatment Provides a Long-Term Survival Benefit for Patients with Advanced Pancreatic Neuroendocrine Tumors: .

J Oncol 2018 14;2018:6273947. Epub 2018 Nov 14.

Pancreatic Surgery Department, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.

Purpose: Nonsurgical therapies, including biotherapy, chemotherapy, and liver-directed therapy, provided a limit survival benefit for PNET patients with hepatic metastases. With the development of liver resection technique, there was a controversy on whether to perform a liver resection for these patients.

Methods: A computerized search was made of the Medline/PubMed, EMbase, Cochrane Library, and SinoMed (CBM) before March 2018. Read More

View Article
November 2018

Nasal Cytology: A Comparative Study of Two Different Techniques of Processing-Smeared versus Cytocentrifuged Slides.

Mediators Inflamm 2018 14;2018:1640180. Epub 2018 Nov 14.

1st Otorhinolaryngology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria Pisana, Via Paradisa 2, 56124 Pisa, Italy.

Nasal cytology is a precious tool to study nasal disorders, but in current literature, there is no consensus on the standardization of the processing procedure of the obtained samples. Therefore, we decided to test on specimens obtained by nasal scraping, a common way of nasal specimen sampling, two different processing techniques, smear and cytocentrifugation, and compare them in terms of inflammatory cell content, quality of slides, and validity on clinical assessment. We analyzed 105 patients with suspected sinonasal diseases, and in each patient, we performed nasal cytology with both techniques. Read More

View Article
November 2018

A novel adhesive biosensor system for detecting respiration, cardiac, and limb movement signals during sleep: validation with polysomnography.

Nat Sci Sleep 2018 26;10:397-408. Epub 2018 Nov 26.

Neurology Department, Massachusetts General Hospital, Boston, MA 02114, USA.

Background: Although in-lab polysomnography (PSG) remains the gold standard for objective sleep monitoring, the use of at-home sensor systems has gained popularity in recent years. Two categories of monitoring, autonomic and limb movement physiology, are increasingly recognized as critical for sleep disorder phenotyping, yet at-home options remain limited outside of research protocols. The purpose of this study was to validate the BiostampRC sensor system for respiration, electrocardiography (ECG), and leg electromyography (EMG) against gold standard PSG recordings. Read More

View Article
November 2018

Construction of a nomogram predicting the overall survival of patients with distantly metastatic non-small-cell lung cancer.

Cancer Manag Res 2018 22;10:6143-6156. Epub 2018 Nov 22.

Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing, People's Republic of China,

Purpose: This study aimed to establish a nomogram to predict the overall survival (OS) of the general non-small-cell lung cancer (NSCLC) patients with distant metastasis.

Patients And Methods: We investigated Surveillance, Epidemiology, and End Results database for NSCLC patients with distant metastasis diagnosed between 2010 and 2014. Statistically significant prognostic factors were identified using uni- and multivariable Cox regression analyses. Read More

View Article
November 2018

Recurrence and prognostic model for identifying patients at risk for esophageal cancer after surgery.

Cancer Manag Res 2018 21;10:6109-6120. Epub 2018 Nov 21.

Department of Thoracic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China,

Objective: The aim of this study was to construct a risk model to assess overall survival (OS) and disease-free survival (DFS) in patients with esophageal cancer (EC) after surgery.

Patients And Methods: A total of 872 consecutive EC patients who had undergone surgery between February 2009 and October 2012 were retrospectively analyzed. The cutoff for risk value (RV) was inferred by receiver operating characteristic curves and the Youden index. Read More

View Article
November 2018

Vasoformative Lesions in Mediastinal Mixed Germ Cell Tumors: an Interesting Account of Two Cases Spanning the Benign to Malignant Spectrum.

Indian J Surg Oncol 2018 Dec 18;9(4):624-628. Epub 2018 May 18.

1Department of Histopathology, Sir Ganga Ram Hospital, Rajender Nagar, New Delhi, India.

Extragonadal germ cell tumors are most commonly encountered in the anterior mediastinum. The presence of sarcomatous malignancies in these tumors is a rare phenomenon that adversely impacts patient prognosis because of poor response to conventional cisplatin-based chemotherapy. Even more unusual is the presence of florid benign somatic proliferations that overshadow the germ cell component, often resulting in misdiagnosis and inappropriate management. Read More

View Article
December 2018

Clinical Utility of Staging Laparoscopy for Advanced Obstructing Rectal Adenocarcinoma: Emerging Tool.

Indian J Surg Oncol 2018 Dec 2;9(4):488-494. Epub 2018 Aug 2.

1Department of Gastrointestinal Surgery and Colorectal Surgical Oncology, Tata Memorial Hospital, Dr Ernest Borges Marg, Parel, Mumbai, Maharashtra 400012 India.

The multimodal treatment for advanced rectal adenocarcinoma mandates accurate preoperative staging with contrast-enhanced computed tomography (CECT) of the thorax, abdomen, and pelvis, and magnetic resonance imaging (MRI) of the pelvis. Unlike gastric cancer, the role of staging laparoscopy (SL) in advanced colorectal cancer has not been evaluated. This study aims to evaluate the clinical value of SL in treatment decision-making for advanced rectal cancer (RC) with near or complete obstructing tumors. Read More

View Article
December 2018

Feasibility, Safety, and Surgical Outcome of Robotic Hemithyroidectomy Via Transaxillary and Retroauricular Approach: an Institutional Experience.

Indian J Surg Oncol 2018 Dec 19;9(4):477-482. Epub 2018 May 19.

Department of Head-Neck and Thoracic Surgical Oncology, Fortis Memorial Research Institute (FMRI), Gurugram, Sector-44, Gurugram, Haryana 122002 India.

The aim of this observational prospective study was to determine the technical feasibility, safety, and adequacy of robotic hemithyroidectomy. From April 2015 to May 2016, 16 patients with solitary thyroid lesion underwent robotic hemithyroidectomy using the Surgical system. Patients were observed and data were recorded on surgical time, blood loss, complications, and functional outcome of the patients. Read More

View Article
December 2018
1 Read

Positive airway pressure for sleep-disordered breathing in acute quadriplegia: a randomised controlled trial.

Thorax 2018 Dec 11. Epub 2018 Dec 11.

Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, St Leonards, New South Wales, Australia.

Rationale: Highly prevalent and severe sleep-disordered breathing caused by acute cervical spinal cord injury (quadriplegia) is associated with neurocognitive dysfunction and sleepiness and is likely to impair rehabilitation.

Objective: To determine whether 3 months of autotitrating CPAP would improve neurocognitive function, sleepiness, quality of life, anxiety and depression more than usual care in acute quadriplegia.

Methods And Measurements: Multinational, randomised controlled trial (11 centres) from July 2009 to October 2015. Read More

View Article
December 2018

Artificial stone-associated silicosis in Belgium: response.

Occup Environ Med 2018 Dec 11. Epub 2018 Dec 11.

Thoracic Medicine, St Vincent's Hospital, Sydney, New South Wales, Australia.

View Article
December 2018

The COX2 effector microsomal PGE2 synthase-1 is a regulator of immunosuppression in cutaneous melanoma.

Clin Cancer Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center

Purpose: Microsomal prostaglandin E2 synthase 1 (mPGES1) was evaluated as an important downstream effector of the cyclooxygenase 2 (COX2) pathway responsible for tumor-mediated immunosuppression in melanoma.

Experimental Design: The analysis of a Stage III melanoma tissue microarray (n=91) was performed to assess the association between mPGES1, COX2, CD8, and patient survival. Pharmacological inhibitors and syngeneic mouse models using mPGES1 knockout mouse melanoma cell lines were used to evaluate the mPGES1-mediated immunosuppressive function. Read More

View Article
December 2018

Cardiac valve calcification and use of anticoagulants: Preliminary observation of a potentially modifiable risk factor.

Int J Cardiol 2018 Nov 29. Epub 2018 Nov 29.

Department of Research, Innovation and Brand Reputation, ASST Papa Giovanni XXIII, Bergamo, Italy. Electronic address:

Aims: Direct oral anticoagulant (DOAC) has been recently introduced in the clinical practice. Rather than interfering with vitamin K-dependent posttranscriptional modification of various proteins, DOACs selectively inhibit factors involved in the coagulation cascade. In particular, in contrast with Warfarin, Rivaroxabn does not interfere with activation of matrix Gla Protein (MGP), a potent vascular calcification Inhibitor. Read More

View Article
November 2018

Anti-anginal drugs: Systematic review and clinical implications.

Int J Cardiol 2018 Dec 4. Epub 2018 Dec 4.

Centro Cardiologico Universitario, University Hospital of Ferrara, Via Aldo Moro 8, 44124 Cona, Ferrara, Italy; Maria Cecilia Hospital, GVM Care & Research, Via Corriera 1, Cotignola, RA, Italy.

Background: The cornerstone of the treatment of patients affected by stable angina is based on drugs administration classified as first (beta-blockers, calcium channel blockers, short acting nitrates) or second line treatment (long-acting nitrates, ivabradine, nicorandil, ranolazine and trimetazidine). However, few data on comparison between different classes of drugs justify that one class of drugs is superior to another.

Methods: We performed a systematic review of the literature following PRISMA guidelines. Read More

View Article
December 2018

Comparison of Outcomes and Frequency of Graft Failure With Use of Free Versus In Situ Internal Mammary Artery Bypass Conduits (from the PREVENT IV Trial).

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina. Electronic address:

Although in situ internal mammary artery (is-IMA) grafting remains the most frequent conduit in coronary artery bypass grafting (CABG), circumstances may necessitate free grafting of the IMA (f-IMA), though differences in outcomes have not been fully characterized. The purpose of this study was to compare clinical and angiographic outcomes of is-IMA versus f-IMA coronary bypass grafts in patients who underwent elective CABG surgery. In 1,829 patients in the angiographic cohort of PREVENT IV, 1,572 (85. Read More

View Article
November 2018

Keeping surgery relevant in oligometastatic non-small cell lung cancer.

J Thorac Cardiovasc Surg 2018 Nov 8. Epub 2018 Nov 8.

Section of Thoracic Surgery, University of Chicago Medicine and Biologic Sciences, Chicago, Ill. Electronic address:

View Article
November 2018

Quality metrics for lung cancer care: Far from perfect, but close to reality.

J Thorac Cardiovasc Surg 2018 Oct 28. Epub 2018 Oct 28.

Valley/Mount Sinai Comprehensive Cancer Care, Paramus, NJ.

View Article
October 2018

Aspirin resistance in the early postoperative period: Pharmacokinetics may be part of the answer.

J Thorac Cardiovasc Surg 2018 Nov 13. Epub 2018 Nov 13.

Cardiovascular and Thoracic Section, Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa. Electronic address:

View Article
November 2018

Stroke after thoracic endovascular aortic repair: Can you "plug" the problem?

J Thorac Cardiovasc Surg 2018 Nov 8. Epub 2018 Nov 8.

Department of Cardiovascular Surgery, University Hospital Bern and University of Bern, Bern, Switzerland. Electronic address:

View Article
November 2018

Anaemia requiring red blood cell transfusion is associated with unfavourable 90-day survival in surgical patients with sepsis.

BMC Res Notes 2018 Dec 11;11(1):879. Epub 2018 Dec 11.

Department of Anesthesiology, University Medical Center, Georg August University, Goettingen, Germany.

Objective: The mortality associated with sepsis remains unacceptably high, despite modern high-quality intensive care. Based on the results from previous studies, anaemia and its management in patients with sepsis appear to impact outcomes; however, the transfusion policy is still being debated, and the ideal approach may be extremely specific to the individual. This study aimed to investigate the long-term impact of anaemia requiring red blood cell (RBC) transfusion on mortality and disease severity in patients with sepsis. Read More

View Article
December 2018