339,669 results match your criteria Thoracic Disc Injuries


GLP1 Receptor Agonist Liraglutide Is an Effective Therapeutic Option for Perioperative Glycemic Control in Type 2 Diabetes within Enhanced Recovery After Surgery (ERAS) Protocols.

Eur Surg Res 2018 Dec 11;59(5-6):349-360. Epub 2018 Dec 11.

Background: Enhanced Recovery After Surgery (ERAS) protocols are multimodal perioperative care pathways designed to achieve early recovery after surgical procedures by maintaining preoperative organ function and reducing profound stress responses following surgery [Wilmore and Kehlet: BMJ 2001; 322(7284): 473-6]. Glucagon-like peptide-1 receptor agonists (GLP-1RAgs), such as liraglutide, have recently been widely used as antidiabetic agents in patients with type 2 diabetes (T2D) because they maintain blood glucose at an ideal level throughout the day, including during postprandial periods, thereby improving hypoglycemia and body weight more than insulin therapies. Additionally, the administration of liraglutide may exert cardiovascular, renal, and cerebral protective effects in T2D patients. Read More

View Article
December 2018

Developing a quality standard for verbal communication during CABG procedures.

Semin Thorac Cardiovasc Surg 2018 Dec 8. Epub 2018 Dec 8.

Department of Cardio-Thoracic Surgery, Leiden University Medical Center, Leiden.

Objective: Verbal communication during coronary artery bypass graft (CABG) procedures is essential for safe and efficient cardiac surgery, yet sensitive to failure due to a current lack of standardization. The goal of this study was to improve communication during CABG by identifying critical items in verbal interaction between surgeons, anesthetists and perfusionists.

Methods: Based on 6 video recordings, a list was assembled containing items of communication in CABG procedures. Read More

View Article
December 2018

Targeting PKCδ as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer.

Cancer Cell 2018 Dec;34(6):954-969.e4

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for Molecular Medicine and Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan. Electronic address:

Multiple mechanisms of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been identified in EGFR-mutant non-small cell lung cancer (NSCLC); however, recurrent resistance to EGFR TKIs due to the heterogeneous mechanisms underlying resistance within a single patient remains a major challenge in the clinic. Here, we report a role of nuclear protein kinase Cδ (PKCδ) as a common axis across multiple known TKI-resistance mechanisms. Specifically, we demonstrate that TKI-inactivated EGFR dimerizes with other membrane receptors implicated in TKI resistance to promote PKCδ nuclear translocation. Read More

View Article
December 2018

Digital pathology is a practical alternative to on-site intra-operative frozen section diagnosis in thoracic surgery.

Histopathology 2018 Dec 11. Epub 2018 Dec 11.

Thoracic Surgery, Bristol Royal Infirmary, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom.

Introduction: Telepathology uses digitised image transfer to allow off-site reporting of histopathology slides. This technology could facilitate the centralisation of pathology services, which may improve their quality and cost-effectiveness. The benefits may be most apparent in frozen section reporting, where turnaround times are vital. Read More

View Article
December 2018

The Competing Risk of Death in Longitudinal Geriatric Outcomes.

J Am Geriatr Soc 2018 Dec 8. Epub 2018 Dec 8.

Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.

Objectives: To address the competing risk of death in longitudinal studies of older persons, we demonstrate sensitivity analyses that evaluate robustness of associations between exposures and three outcome types: dichotomous, count, and time to event.

Design: A secondary analysis of data from a prospective cohort study.

Setting: Community-based data from the Precipitating Events Project in New Haven, CT. Read More

View Article
December 2018

Independent and joint associations of blood lipids and lipoproteins with lung cancer risk in Chinese males: A prospective cohort study.

Int J Cancer 2018 Dec 11. Epub 2018 Dec 11.

Department of Thoracic Surgery, National Cancer Center / National Clinical Research Center for Cancer / Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

To investigate the independent and joint associations of blood lipids and lipoproteins with lung cancer risk in Chinese males, a prospective cohort study was conducted. A total of 109,798 males with baseline information on total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and non-HDL were prospectively observed from 2006 to 2015 for cancer incidence. Cox proportional hazards models and restricted cubic spline (RCS) analysis were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Read More

View Article
December 2018

The lymph node status and histologic subtypes influenced the effect of postoperative radiotherapy on patients with N2 positive IIIA non-small cell lung cancer.

J Surg Oncol 2018 Dec 9. Epub 2018 Dec 9.

Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.

Background And Objective: To investigate the role of postoperative radiotherapy (PORT) in IIIA-N2 non-small cell lung cancer (NSCLC) patients and subgroups which derived benefit from PORT.

Methods: A total of 576 patients with pathological IIIA-N2 NSCLC, who underwent complete resection, were identified. Propensity score matching (PSM) methods were used to balance the patients' characteristics between two groups. Read More

View Article
December 2018

microRNA-148a-3p inhibited the proliferation and epithelial-mesenchymal transition progression of non-small-cell lung cancer via modulating Ras/MAPK/Erk signaling.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Cardiothoracic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Son of sevenless (SOS) is one of the guanine nucleotide exchange factors that can regulate the mitogen-activated protein kinase/extracellular signal regulated kinase signal pathway via controlling the activation of Ras. microRNAs are key regulon of gene expression and would be treated as tumor biomarkers or therapeutic targets. In this study, we find that miR-148a-3p acts as a tumor-suppressor in the development and progression of non-small-cell lung cancer (NSCLC). Read More

View Article
December 2018

Prospective exosome-focused translational research for afatinib study of non-small cell lung cancer patients expressing EGFR (EXTRA study).

Thorac Cancer 2018 Dec 8. Epub 2018 Dec 8.

Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.

Patients with EGFR-mutated non-small cell lung cancer (NSCLC) exhibit resistance to EGFR-tyrosine kinase inhibitors (TKIs) within 9-14 months of therapy. Recently, EGFR-mutated NSCLC has demonstrated the potential for heterogeneity; therefore, the manner of clonal heterogeneity may impact the duration of progression-free and overall survival and other parameters affecting EGFR-TKI treatment efficacy. However no predictive biomarker of these favorable treatment efficacies has been identified to date. Read More

View Article
December 2018

Assessment of within-breath impulse oscillometry parameters in children with asthma.

Pediatr Pulmonol 2018 Dec 10. Epub 2018 Dec 10.

Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.

Background: Impulse oscillometry (IOS) measures respiratory resistance and reactance during tidal breaths and is a convenient tool for evaluation of lung function. Respiratory resistance and reactance can be measured separately during inspiration and expiration (inspiratory-expiratory analysis).

Objective: We investigated the differences in inspiratory-expiratory measurements obtained using IOS between children with and without asthma. Read More

View Article
December 2018

Clinical significance of ≥ 50% PD-L1 expression with the SP263 monoclonal antibody in non-small cell lung cancer patients.

Thorac Cancer 2018 Dec 11. Epub 2018 Dec 11.

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: PD-L1 expression in tumor cells has been associated with the efficacy of immune checkpoint inhibitors in non-small cell lung cancer (NSCLC). The aim of this study was to explore correlations between smoking, genetic profiles, patient outcomes, and PD-L1 expression in NSCLC.

Methods: PD-L1 expression was evaluated in 241 surgically resected specimens by immunostaining and 50% was set as the cutoff value. Read More

View Article
December 2018

Modeling and multi-scale characterization of the quantitative imaging based fibrosis index reveals pathophysiological, transcriptome and proteomic correlates of lung fibrosis induced by fractionated irradiation.

Int J Cancer 2018 Dec 11. Epub 2018 Dec 11.

Translational Radiation Oncology, German Cancer Consortium (DKTK), National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Pulmonary fibrosis represents a leading cause of morbidity and mortality worldwide. Therapy induced lung fibrosis constitutes a pivotal dose-limiting side effect of radiotherapy and other anticancer agents. We aimed to develop objective criteria for assessment of fibrosis and discover pathophysiological and molecular correlates of lung fibrosis as a function of fractionated whole thoracic irradiation. Read More

View Article
December 2018

Identification of Key Genes and Pathways in Diabetic Nephropathy by Bioinformatics Analysis.

J Diabetes Investig 2018 Dec 9. Epub 2018 Dec 9.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, China.

Aims: The aim of the study is to identify candidate differentially expressed genes (DEGs) and pathways using bioinformatics analysis and improve our understanding of the cause and potential molecular events of diabetic nephropathy (DN).

Materials And Methods: Two cohort profile datasets (GSE30528 and GSE33744) were integrated and used for deep analysis. We sorted DEGs and analyzed differential pathway enrichment. Read More

View Article
December 2018

Removal Efficacy of Opportunistic Pathogens and Bacterial Community Dynamics in Two Drinking Water Treatment Trains.

Small 2018 Dec 7:e1804436. Epub 2018 Dec 7.

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai, 200433, China.

Drinking water treatment processes (DWTPs) impact pathogen colonization and microbial communities in finished water; however, their efficacies against opportunistic pathogens are not fully understood. In this study, the effects of treatment steps on the removal of Legionella spp., Legionella pneumophila, nontuberculous mycobacteria, Mycobacterium avium, and two amoeba hosts (Vermamoeba vermiformis, Acanthamoeba) are evaluated in two parallel trains of DWTPs equipped with different pretreatment units. Read More

View Article
December 2018

Galectin-3 exacerbates ox-LDL-mediated endothelial injury by inducing inflammation via integrin β1-RhoA-JNK signaling activation.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Geriatric Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Oxidized low-density lipoprotein (Ox-LDL)-induced endothelial cell injury plays a crucial role in the pathogenesis of atherosclerosis (AS). Plasma galectin-3 (Gal-3) is elevated inside and drives diverse systemic inflammatory disorders, including cardiovascular diseases. However, the exact role of Gal-3 in ox-LDL-mediated endothelial injury remains unclear. Read More

View Article
December 2018

Genetic testing and surveillance guidelines in hereditary pheochromocytoma and paraganglioma.

J Intern Med 2018 Dec 8. Epub 2018 Dec 8.

Clinical Genetics, Karolinska University Hospital, 171 76, Stockholm.

Pheochromocytomas (PCC) and paragangliomas (PGL), collectively abbreviated PPGL are rare tumours originating from the chromaffin cells in the adrenal medulla (PCC) or the sympathetic or parasympathetic extra-adrenal paraganglia (PGL) (1, 2), Figure 1. The enlarged cell volume leads to increased levels of catecholamines (adrenaline, noraderenaline and/or dopamine) and their metabolites which can be measured in plasma or urine for biochemical diagnosis. Hormone-producing PPGL commonly originate from sympathetic paraganglia in the adrenal glands, abdomen or pelvis (3). Read More

View Article
December 2018

[Registry Research Funding of the German Society of Plastic, Reconstructive and Aesthetic Surgeons (DGPRÄC) and Research Funding Report 2017/2018].

Handchir Mikrochir Plast Chir 2018 Dec 10. Epub 2018 Dec 10.

Klinik und Poliklinik für Plastische, Hand- und Wiederherstellungschirurgie, Medizinische Hochschule Hannover.

Introduction: This report serves to publicize the research of academic institutions for Plastic Surgery within our society DGPRÄC in 2017/2018 and sequels the funding report of 2015/2016. Applications to public, non-public, or industrial funding organizations were evaluated. At the same time, this paper analyses the number of approved DFG applications in Plastic, Thoracic and Vascular Surgery in the GEPRIS system. Read More

View Article
December 2018

Preoperative brain MRI for clinical stage IA lung cancer: is routine scanning rational?

J Cancer Res Clin Oncol 2018 Dec 7. Epub 2018 Dec 7.

Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai, 200032, China.

Purpose: Early detection and control of lung cancer brain metastases (BMs) are important. However, several guideline recommendations are inconsistent with regard to routine preoperative brain MRI, especially in patients with clinical stage IA lung cancer. Our study evaluated the value of preoperative brain MRI in patients with clinical stage IA lung cancer. Read More

View Article
December 2018
2 Reads

Prognostic Factors of Pathological N1 Non-small Cell Lung Cancer After Curative Resection Without Adjuvant Chemotherapy.

World J Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.

Background: The aim of this study was to evaluate the outcomes of patients with pathological N1 non-small cell lung cancer who did not receive adjuvant chemotherapy. We attempted to identify those patients for whom adjuvant chemotherapy would be indispensable.

Methods: Among 132 patients who were diagnosed with pathological N1 lung cancer at a single institution from January 2010 to December 2016 were 32 patients who did not receive adjuvant treatment after curative surgical resection. Read More

View Article
December 2018

The dilemma of patient age in decision-making for extracorporeal life support in cardiopulmonary resuscitation.

Intensive Care Med 2018 Dec 7. Epub 2018 Dec 7.

Department of Clinical Medicine, University of Bergen/Haukeland University Hospital, Bergen, Norway.

View Article
December 2018

Central compartment revision surgery for persistent or recurrent thyroid carcinoma: analysis of survival and complication rate.

Eur Arch Otorhinolaryngol 2018 Dec 10. Epub 2018 Dec 10.

Otorhinolaryngology-Head and Neck Surgery Department, University Hospital of Modena, Largo del Pozzo, 71, 41125, Modena, Italy.

Purpose: Locoregional recurrence of thyroid carcinoma is relatively common and reported rate are between 5 and 20%. Cervical nodes are usually involved, especially at the central compartment. The management of recurrent thyroid carcinoma at central compartment still remains challenging because of higher incidence of complication rate. Read More

View Article
December 2018

Unusual osteological findings in sacred relics from the LESJE monastery in central Serbia.

Forensic Sci Med Pathol 2018 Dec 7. Epub 2018 Dec 7.

School of Medicine, The University of Adelaide, and Forensic Science South Australia (FSSA), Level 2 Medical School North Building, Frome Road, Adelaide, South Australia, 5005, Australia.

An adult male skeleton was submitted to the Department of Anatomy at the University of Belgrade for evaluation. It was believed to represent the remains of a second to third century Christian saint from the Lesje Monastery in central Serbia. Examination of the remains revealed an old crush fracture of a thoracic vertebra and an unusual, probably congenital, malformation of the atlanto-occipital joint with deformation of the left occipital condyle and resultant narrowing of the foramen magnum. Read More

View Article
December 2018

Mobile Workflow in Computed Tomography of the Chest.

J Med Syst 2018 Dec 10;43(1):14. Epub 2018 Dec 10.

Department of Radiology, University Hospital Erlangen, Maximiliansplatz 3, 91054, Erlangen, Germany.

A CT system with a tablet as mobile user interface and a wireless remote control for positioning and radiation release has recently been presented. Our aim was to evaluate the effects of a mobile CT examination workflow on the radiographers' performance compared to conventional examinations. A prototype of a radiation protection cabin was installed besides the gantry of a CT system. Read More

View Article
December 2018

F-FDG PET/CT diagnostic performance in solitary and multiple pulmonary nodules detected in patients with previous cancer history: reports of 182 nodules.

Eur J Nucl Med Mol Imaging 2018 Dec 8. Epub 2018 Dec 8.

Nuclear Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Francesco Vito, 1, 00168, Roma, Italia.

Purpose: In oncological patients, F-FDG PET/CT performance for pulmonary nodules' characterization is not well-established. Thus, the purpose of this study was to evaluate the F-FDG PET/CT diagnostic performance in pulmonary nodules detected during follow-up in oncological patients and the relationship between malignancy and nodules' characteristics.

Methods: We retrospectively evaluated 182 pulmonary nodules (121 solitary, 61 multiple; mean size = 16. Read More

View Article
December 2018

Imaging and Surgical Treatment of Primary Pulmonary Artery Sarcoma.

Int J Cardiovasc Imaging 2018 Dec 8. Epub 2018 Dec 8.

Houston Methodist DeBakey Heart and Vascular Center, Houston, TX, USA.

Primary pulmonary artery sarcoma is a rare tumor originating from the pulmonary artery tree. Given the low incidence, few centers have reported on more than a handful of cases. Because of its rarity it is also commonly misdiagnosed as pulmonary embolism. Read More

View Article
December 2018

Long non‑coding RNA DANCR promotes HMGA2‑mediated invasion in lung adenocarcinoma cells.

Oncol Rep 2018 Nov 30. Epub 2018 Nov 30.

Department of Thoracic Surgery, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning 110024, P.R. China.

Long non‑coding RNAs (lncRNAs) have been reported to be key regulators in various types of cancer, including lung adenocarcinoma (LAD). The roles of the lncRNA differentiation antagonizing non‑protein coding RNA (DANCR) and high mobility group AT‑hook 2 (HMGA2) in LAD remain unclear. In the present study, it was revealed that the lncRNA DANCR was upregulated in LAD tissue and cell lines, compared with para‑tumor tissue and a normal lung cell line. Read More

View Article
November 2018

Wnt/β‑catenin inhibition reverses multidrug resistance in pediatric acute lymphoblastic leukemia.

Oncol Rep 2018 Dec 4. Epub 2018 Dec 4.

Department of Pediatrics, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China.

Although ~80% of newly diagnosed pediatric patients with acute lymphoblastic leukemia (ALL) become disease‑free following appropriate treatment, relapses frequently occur, with dismal prognosis. Therefore, it is urgent to develop novel therapeutic modalities. Resistance to chemotherapy is a major obstacle for the treatment of relapsed ALL. Read More

View Article
December 2018

Long non‑coding RNA MLK7‑AS1 promotes proliferation in human colorectal cancer via downregulation of p21 expression.

Mol Med Rep 2018 Nov 28. Epub 2018 Nov 28.

Department of Thoracic Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China.

Current studies have highlighted long non‑coding RNAs (lncRNAs) as critical regulators in various cancers, including colorectal cancer (CRC). By utilizing publicly available data from The Cancer Genome Atlas dataset, MLK7 antisense RNA 1 (MLK7‑AS1) was identified as a novel lncRNA that correlated with CRC progression. The results of reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) revealed a significant upregulation of MLK7‑AS1 in both CRC tissue samples and cell lines. Read More

View Article
November 2018

lincRNA‑p21 inhibits the progression of non‑small cell lung cancer via targeting miR‑17‑5p.

Oncol Rep 2018 Nov 30. Epub 2018 Nov 30.

The Second Clinical Medical College, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.

Non‑small‑cell lung cancer (NSCLC) is well established as one of the major subtypes of human lung cancer. NSCLC is characterized by a high incidence rate and poor patient prognosis. Previous studies have identified that long intergenic non-coding RNA (lincRNA) serves a key role in the development of tumor and malignant metastasis. Read More

View Article
November 2018

Assessment of geometrical remodelling of the aortic arch after hybrid treatment.

Eur J Cardiothorac Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of Vascular and Endovascular Surgery, Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy.

Objectives: The aim of this study was to measure the morphological remodelling of the ascending aorta, aortic arch and thoracic aorta after aortic arch hybrid treatment including debranching and stent graft implantation.

Methods: Preoperative, 1-month and 1-year follow-up of computed tomography angiography scans of 22 patients were analysed to compute the lumen centreline from the aortic root to the coeliac trunk, and the following measurements were derived: the total centreline length, distance from the aortic root to the left subclavian artery, distance from the left subclavian artery to the distal landing zone. For both pre- and postoperative centrelines, the pointwise curvature was measured at the proximal and the distal landing zones. Read More

View Article
December 2018

Thoracic endografting increases cardiac afterload and leads to left ventricular hypertrophy in dogs.

Eur J Cardiothorac Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of Cardiovascular Surgery, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Objectives: Aortic endografting can cause aortic stiffening. We aimed to determine the chronic effect of thoracic endografting on cardiac afterload, function and remodelling.

Methods: Eleven dogs were included, and all except 1 was successfully assessed [endograft, n = 5; sham operation (control), n = 5]. Read More

View Article
December 2018

Combined modality treatment for malignant pleural mesothelioma: a single-centre long-term survival analysis using extrapleural pneumonectomy.

Eur J Cardiothorac Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Thoracic Surgery, University Hospitals KU Leuven, Leuven, Belgium.

Objectives: Combined modality treatment (CMT) for malignant pleural mesothelioma (MPM) remains a matter of debate regarding the choice of surgical procedure: extrapleural pneumonectomy (EPP) or pleurectomy/decortication.

Methods: We performed a prospective interventional cohort study between 2003 and 2014. All consecutive patients with any histological MPM subtype, ≤70 years old, World Health Organization performance status ≤1, medically fit for pneumonectomy and stage cT1-2cN0-2cM0 (TNM7) or lower were included. Read More

View Article
December 2018

Cardiac remodelling following thoracic endovascular aortic repair for descending aortic aneurysms.

Eur J Cardiothorac Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Surgery, University of Michigan, Ann Arbor, MI, USA.

Objectives: Current endografts for thoracic endovascular aortic repair (TEVAR) are much stiffer than the aorta and have been shown to induce acute stiffening. In this study, we aimed to estimate the impact of TEVAR on left ventricular (LV) stroke work (SW) and mass using a non-invasive image-based workflow.

Methods: The University of Michigan database was searched for patients treated with TEVAR for descending aortic pathologies (2013-2016). Read More

View Article
December 2018

The Modified Arch Landing Areas Nomenclature identifies hostile zones for endograft deployment: a confirmatory biomechanical study in patients treated by thoracic endovascular aortic repair.

Eur J Cardiothorac Surg 2018 Dec 7. Epub 2018 Dec 7.

Division of Vascular Surgery II, IRCCS-Policlinico San Donato, San Donato Milanese, Italy.

Objectives: Our goal was to confirm whether the Modified Arch Landing Areas Nomenclature (MALAN) for thoracic endovascular aortic repair, in which each landing area is described by indicating both the proximal landing zone (PLZ) and the type of arch (e.g. 0/I), identifies unfavourable landing zones for endograft deployment in diseased aortas. Read More

View Article
December 2018

Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies.

Am J Clin Nutr 2018 Sep;108(3):453-475

Departments of Complex Genetics.

Background: Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes. Read More

View Article
September 2018

Significant parameters in the evaluation of donor lungs in single-lung cellular ex vivo lung perfusion.

Interact Cardiovasc Thorac Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

Objectives: Typically, single-lung ex vivo lung perfusion (SL-EVLP) is preferred when there is concern of contamination from the opposite lung. However, a comprehensive assessment of the SL-EVLP has not been completed. The purpose of this study is to compare the physiological parameters of SL-EVLP and double-lung EVLP (DL-EVLP) in the assessment of transplant suitability. Read More

View Article
December 2018

Combined checkpoint inhibitor-associated myocarditis and pulmonary vasculitis mimicking acute pulmonary embolism.

Eur Heart J Cardiovasc Imaging 2018 Dec 11. Epub 2018 Dec 11.

Cardio-Thoracic-Vascular Department, San Raffaele Hospital, Via Olgettina 60, Milan 20132, Italy.

View Article
December 2018

Extracorporeal membrane oxygenation for refractory cardiogenic shock: patient survival and health-related quality of life.

Eur J Cardiothorac Surg 2018 Dec 10. Epub 2018 Dec 10.

Department of Cardiology, Heart and Lung Center, Helsinki University Hospital, Helsinki, Finland.

Objectives: Our goal was to study the outcome of patients with cardiogenic shock who were treated with venoarterial extracorporeal membrane oxygenation (VA ECMO), including the subsequent long-term health-related quality of life (HRQoL).

Methods: We conducted a retrospective study of 133 consecutive patients treated in a single centre from 2007 to 2016. The HRQoL was studied using the EuroQuol-5 dimensions-3 level questionnaire and the RAND 36-Item Short Form Health Survey at a minimum of 1 year after VA ECMO. Read More

View Article
December 2018

Identifying the anti-inflammatory response to lipid lowering therapy. A Position Paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology.

Cardiovasc Res 2018 Dec 6. Epub 2018 Dec 6.

Karolinska Institutet, Stockholm, Sweden.

Dysregulated lipid metabolism induces an inflammatory and immune response leading to atherosclerosis. Conversely, inflammation may alter lipid metabolism. Recent treatment strategies in secondary prevention of atherosclerosis support beneficial effects of both anti-inflammatory and lipid-lowering therapies beyond current targets. Read More

View Article
December 2018

Effects of triple-treatment trunk stretching on physical fitness and curvature of the spine.

Heliyon 2018 Dec 1;4(12):e00985. Epub 2018 Dec 1.

Shinshu University, Faculty of Education, 6-Ro Nishinagano, Nagano City, Nagano 380-8544, Japan.

Background: Research on the effectiveness of treatment for low back disorders has been made, however yet no established method has been found. Therefore, we devised a triple-treatment trunk stretching program comprising the following three trunk stretching exercises: stretching using an unstable flex chair; stretching using a stretching bench; and stretching using a stretch pad. Our three-treatment trunk stretching program is based on the principles of static muscular stabilization of the spine and uses well-known physiological strength-training principles. Read More

View Article
December 2018
1 Read

Retransplantation Outcomes at a Large Lung Transplantation Program.

Transplant Direct 2018 Nov 25;4(11):e404. Epub 2018 Oct 25.

DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, TX.

Background: With the increase of primary lung transplantation across major centers worldwide, over the last several years the need of lung retransplant (ReTX) is likely to increase. Therefore, characterization of ReTX patients is prudent and necessary. Our study aimed to investigate and characterize the covariates and outcomes associated with lung ReTX survival in a single large U. Read More

View Article
November 2018

Unilateral Chronic Lung Allograft Dysfunction Assessed by Biphasic Computed Tomographic Volumetry in Bilateral Living-donor Lobar Lung Transplantation.

Transplant Direct 2018 Nov 12;4(11):e398. Epub 2018 Oct 12.

Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: Early diagnosis of unilateral chronic lung allograft dysfunction (CLAD) is difficult because the unaffected contralateral lung functions as a reservoir in bilateral living-donor lobar lung transplantation (LDLLT). We previously reported the usefulness of Xe ventilation scintigraphy for detection of unilateral change, but the supply of Xe has been stopped globally. The present study aimed to examine the usefulness of inspiratory and expiratory computed tomography (I/E CT) volumetry for detection of unilateral change in CLAD patients. Read More

View Article
November 2018

Testing Pathological Variation of White Matter Tract in Adult Rats after Severe Spinal Cord Injury with MRI.

Biomed Res Int 2018 11;2018:4068156. Epub 2018 Nov 11.

Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.

The purpose of this study was to assess the pathological variation in white matter tracts in the adult severe thoracic contusion spinal cord injury (SCI) rat models combined with in vivo magnetic resonance imaging (MRI), as well as the effect of spared white matter (WM) quantity on hindlimb motor function recovery. 7.0T MRI was conducted for all experimental animals before SCI and 1, 3, 7, and 14 days after SCI. Read More

View Article
November 2018
1 Read

A symptomatic anterior mediastinal mass with a simultaneous infection.

Respirol Case Rep 2019 Feb 4;7(2):e00394. Epub 2018 Dec 4.

Division of Thoracic Surgery, Department of Surgery Taipei Veterans General Hospital Taipei Taiwan.

Surgical resection remains the treatment of choice for mature mediastinal teratoma, and the operation itself is sometimes complicated or life-threatening, especially when it ruptures into adjacent vital structures. We describe a rare case of unanticipatedly delayed complete resection of a symptomatic teratoma with simultaneous infection, followed by extended rupture into the pleural space, lung, and bronchus. The clinical presentation and the microbiological and radiologic features may lead to the impression of a lung abscess until it can be proven otherwise pathologically after an initial thoracic aspiration. Read More

View Article
February 2019
1 Read

Prognostic impact of pretreatment lymphocyte-to-monocyte ratio in advanced epithelial cancers: a meta-analysis.

Cancer Cell Int 2018 6;18:201. Epub 2018 Dec 6.

1Department of Thoracic Surgery, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Gusu District, Suzhou, 215004 China.

Background: There is increasing evidence that inflammation-based biomarkers are associated with tumor microenvironment which plays important roles in cancer progression. A high lymphocyte-to-monocyte ratio (LMR), has been suggested to indicate favorable prognoses in various epithelial cancers. We performed a meta-analysis to quantify the prognostic value of LMR in advanced-stage epithelial cancers undergoing various treatment. Read More

View Article
December 2018

Indole Alkaloid Derivative B, a Novel Bifunctional Agent That Mitigates 5-Fluorouracil-Induced Cardiotoxicity.

ACS Omega 2018 Nov 21;3(11):15850-15864. Epub 2018 Nov 21.

Department of Chemistry and Biological Sciences, Michigan Technological University, Houghton, Michigan 49931, United States.

Clinically approved therapeutics that mitigate chemotherapy-induced cardiotoxicity, a serious adverse effect of chemotherapy, are lacking. The aim of this study was to determine the putative protective capacity of a novel indole alkaloid derivative B () against 5-fluorouracil (5-FU)-induced cardiotoxicity. To assess the free-radical scavenging activities of , the acetylcholine-induced relaxation assay in rat thoracic aorta was used. Read More

View Article
November 2018

Transapical thoracic endovascular aortic repair in aortic arch aneurysm through a pre-existent bioprosthetic aortic valve.

J Vasc Surg Cases Innov Tech 2018 Dec 20;4(4):265-267. Epub 2018 Nov 20.

Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, Saga, Japan.

An 80-year-old man had undergone Y-graft replacement for ruptured abdominal aortic aneurysm followed by bioprosthetic aortic valve replacement. Follow-up computed tomography revealed a 65-mm aneurysm at the distal aortic arch. We selected endovascular surgery because of the patient's high-risk condition, and the extreme curvature of the 8-mm artificial blood vessels led us to adopt a transapical approach. Read More

View Article
December 2018

Lateral approach of exploratory laparotomy through the open chest wall injury.

Trauma Case Rep 2018 Dec 28;18:52-55. Epub 2018 Nov 28.

Division of Trauma Surgery, Department of Surgery, Ajou University School of Medicine, Republic of Korea.

A combined laparotomy and thoracotomy is required in a few trauma patients. The anterior approach is a standard procedure used in such cases; however, a different approach may be required. Recently, we managed a patient who presented with a crush injury to the left side of his chest with associated bowel herniation. Read More

View Article
December 2018