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J Vet Cardiol 2022 May 18;42:43-46. Epub 2022 May 18.

Cummings School of Veterinary Medicine at Tufts University, 200 Westboro Rd, North Grafton, MA 01536, USA.

A nine-year-old male, castrated Pembroke Welsh Corgi presented with a two-month history of lethargy, hyporexia, and occasional vomiting. There was also a two-week history of exercise intolerance; no syncopal episodes were reported. Auscultation revealed bradycardia with an irregular rhythm and otherwise normal heart and lung sounds. Read More

Cardiol Res Pract 2022 25;2022:8758617. Epub 2022 May 25.

No.2 Clinic, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Background: Preventing in-hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI) is a crucial step.

Objectives: The objective of our research was to develop and externally validate the diagnostic model of in-hospital mortality in acute STEMI patients used artificial intelligence methods.

Methods: We divided nonrandomly the American population with acute STEMI into a training set, a test set, and a validation set. Read More

Heart Vessels 2022 May 14. Epub 2022 May 14.

Department of Cardiovascular Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.

Atrioventricular Block (AVB) is one of the common manifestations in cardiac sarcoidosis (CS). Although pacemaker implantation is generally recommended in patients with CS complicated by symptomatic AVB, some case reports have shown that they can be managed by steroid therapy without pacemaker implantation. The aim of this study was to evaluate the feasibility and effectiveness of steroid therapy without pacemaker implantation in patients with CS complicated by symptomatic AVB. Read More

Curr Probl Cardiol 2022 May 12:101247. Epub 2022 May 12.

The University of Cape Town, Faculty of Health Sciences, Department of Medicine, Division of Cardiology; Groote Schuur Hospital, E17 Cardiac Clinic.

Background: There is a paucity of data regarding the aetiology of atrioventricular heart block (AVB) in young and middle-aged patients, particularly from low- and middle-income countries.

Objective: To determine the aetiology of AVB in patients ≤ 55 years treated with transvenous pacemakers in a low- or middle-income country.

Methods: We performed a retrospective review of all patients who received a transvenous pacemaker for newly diagnosed AVB from 01/01/2013 to 31/12/2020 at Groote Schuur Hospital, Cape Town, South Africa. Read More

Orphanet J Rare Dis 2022 05 7;17(1):183. Epub 2022 May 7.

The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, 523710, Guangdong Province, China.

Background: Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is associated with ventricular arrhythmia, heart failure (HF), and sudden death. Thromboembolism is also an important and serious complication of ARVC/D. However, the etiology of ARVC/D and thromboembolism and their association with genetic mutations are unclear. Read More

J Cardiovasc Electrophysiol 2022 May 4. Epub 2022 May 4.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Introduction: Left bundle branch area pacing (LBBAP) maintains electrical and mechanical synchronization of the ventricles. It is a relatively physiological pacing mode, with low and stable pacing threshold and wider indications. LBBAP in children has been rarely reported. Read More

CASE (Phila) 2022 Apr 8;6(2):83-86. Epub 2022 Jan 8.

Clinica Veterinaria Malpensa, Samarate, Varese, Italy.

Front Cardiovasc Med 2022 4;9:821960. Epub 2022 Apr 4.

Department of Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Atrial fibrillation (AF) is the most common arrhythmia, and the incidence increases rapidly all over the world. The global prevalence of AF (age-adjusted) is 0.60% for men and 0. Read More

J Vet Cardiol 2022 Mar 16;41:194-198. Epub 2022 Mar 16.

Queen's Veterinary School Hospital, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK. Electronic address:

A one-year-old female English Springer Spaniel with no previous history of cardiac disease presented to the Queen's Veterinary School Hospital following a blunt traumatic incident with an acquired, direct Gerbode defect and associated third-degree atrioventricular block. Two months after the initial incident, follow-up echocardiography showed a nearly closed Gerbode defect with just trivial residual flow. A 24-h Holter monitor indicated second-degree atrioventricular block with occasional junctional tachycardia. Read More

Expert Rev Gastroenterol Hepatol 2022 May;16(5):411-423

Division of Gastroenterology and Hepatology, Northwestern University-Feinberg School of Medicine, Chicago, Illinois, USA.

Introduction: Ozanimod is a sphingosine-1-phosphate (S1P) modulator that inhibits lymphocyte trafficking from lymph nodes to the circulation. It is approved by the US Food and Drug Administration (FDA) for the treatment of relapsing multiple sclerosis and most recently for the management of moderate-severe ulcerative colitis (UC).

Areas Covered: Here we review the status of drugs approved for moderate-severe UC, the unmet needs in the management of UC, proposed mechanisms of action of S1P modulators, clinical data regarding ozanimod in UC, and emerging S1P modulators being evaluated in inflammatory bowel disease. Read More

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221077815

Neonatology Department, Centro Hospitalar Universitário de São João, Porto, Portugal.

Neonatal lupus is a rare entity, secondary to placental transfer of antibodies from mothers with immune-mediated conditions. While pulmonary involvement is common in lupus, its incidence in neonates is extremely rare, with very few cases being reported in the literature. The authors report a case of a neonate whose mother was diagnosed with systemic lupus erythematosus, with a prenatal diagnosis of third-degree atrioventricular block. Read More

Bull Exp Biol Med 2022 Mar 30;172(5):612-616. Epub 2022 Mar 30.

A. V. Vishnevsky National Medical Research Center of Surgery, Ministry of the Health of the Russian Federation, Moscow, Russia.

We developed a new technique of noninvasive stereotactic radioablation for the treatment of life-threatening tachyrhythmias. The study is performed on pigs (Sus scrofa domesticus). The zones of planned exposure were atrioventricular node (heart loading dose 40 Gy) and the apex of the left ventricle with a part of the interventricular septum (35 Gy) in animal No. Read More

Cureus 2022 Feb 16;14(2):e22269. Epub 2022 Feb 16.

Internal Medicine, Health Corporation of America-University of Central Florida (HCA-UCF) Consortium, Ocala, USA.

Infective endocarditis (IE) occurs when bacterial or fungal pathogens enter the blood and attach to the endocardium. Right-sided endocarditis is usually associated with intravenous drug use (IVDU), intracardiac devices, and central venous catheters. There is more data published about left-side endocarditis when compared to right-sided endocarditis. Read More

J Electrocardiol 2022 May-Jun;72:61-65. Epub 2022 Mar 17.

Department of Cardiovascular Medicine, The Affiliated Hospital of Qingdao University, Qingdao 266000, China. Electronic address:

Objective: To explore the effect of left bundle branch pacing (LBBP) on left ventricular systolic function and synchronization in patients with third-degree atrioventricular block.

Methods: Fifty patients with third-degree atrioventricular block from 2019- to 01-01 to 2019-6-31 in The Affiliated Hospital of Qingdao University who were eligible for pacing indications were selected. According to different pacing locations, they were randomly divided into LBBP group and right ventricular septal pacing (RVSP) group. Read More

Eur J Case Rep Intern Med 2022 23;9(2):003026. Epub 2022 Feb 23.

Department of Internal Medicine, Michigan State University at Hurley Medical Center, Flint, MI, USA.

Coronavirus disease (COVID-19) has infected millions of people worldwide. Its cardiac presentations include myocarditis, arrhythmias and structural heart changes even in young and healthy individuals. The long-term sequelae of these manifestations are unknown. Read More

J Vet Cardiol 2022 Feb 2;41:44-56. Epub 2022 Feb 2.

Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS, 66506, USA.

Introduction/objectives: Minimal information exists regarding epicardial pacemaker (EP) implantation in pet ferrets (Mustela putorius furo). The objectives were to describe the indications, surgical technique, and outcome of EP implantation in ferrets for the treatment of advanced atrioventricular block (AVB).

Animals, Materials, And Methods: Eight client-owned ferrets presenting to five veterinary referral centers. Read More

Saudi J Kidney Dis Transpl 2021 Jul-Aug;32(4):1146-1151

Department of Internal Medicine, Nephrology Division, King Fahd Hospital of the University, Al Khobar, Saudi Arabia.

Cardiovascular diseases are the main cause of morbidity and mortality in end-stage renal disease (ESRD) patients. Cardiac arrhythmias are prevalent in patients undergoing hemodialysis (HD), however, dialysis treatment per se can be considered as an arrhythmogenic stimulus. Uremic patients are characterized by a "pro-arrhythmic substrate" because of the high prevalence of ischemic heart disease, left ventricular hypertrophy, and autonomic neuropathy. Read More

Medicina (Kaunas) 2022 Feb 20;58(2). Epub 2022 Feb 20.

Department of Internal Medicine, University of Medicine and Pharmacy "Grigore T. Popa" Iași, 700115 Iași, Romania.

: Drug-related bradyarrhythmia is a well-documented major adverse event among beta-blocker users and a potential cause for hospitalization or additional interventions. Whether beta-blocker use is associated with specific bradyarrhythmia presentations, and how this relates to other predisposing factors, is not well known. We aim to evaluate the association between beta-blocker use and the type of atrioventricular (AV) conduction disorder in patients with symptomatic bradycardia. Read More

ASAIO J 2022 Feb 16. Epub 2022 Feb 16.

From the Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany Department of Internal Medicine - Cardiology, German Heart Center Berlin, Berlin, Germany Department of Cardiac Anesthesiology and Intensive Care Medicine, German Heart Center Berlin, Berlin, Germany Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany Department of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland.

As patients on long-term left ventricular assist device (LVAD) face a substantial risk for open cardiac reoperation, interventional treatment approaches are becoming increasingly important in this population. We evaluated data of 871 patients who were on LVAD support between January 1, 2016 and December 1, 2020. Interventional treatments for LVAD-associated complications were performed in 76 patients. Read More

J Comp Pathol 2022 Jan 29;190:36-44. Epub 2022 Jan 29.

Laboratory of Veterinary Clinical Oncology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.

The histopathological features of the atrioventricular (AV) conduction system of nine cats with high-grade atrioventricular block (H-AVB) were compared with those of 22 cases of third-degree atrioventricular block (3-AVB). All nine H-AVB cats had experienced syncopal attacks of variable severity and had been diagnosed electrocardiographically. The AVB, which was permanent in all cases, had been observed for 15-1,981 days (average 663 days) before death. Read More

J Med Case Rep 2022 Feb 10;16(1):77. Epub 2022 Feb 10.

Department of Adult Cardiology, Jakaya Kikwete Cardiac Institute, P.O Box 65141, Dar es Salaam, Tanzania.

Introduction: Notwithstanding the diagnostic and therapeutic advancements, the incidence of cardiac metastases has increased in recent decades. Lung cancers are the most common primary malignant neoplasms with cardiac metastasis potential. The clinical presentation of cardiac metastases is either silent or vague, and largely depends on the infiltrated location and tumor burden. Read More

Cureus 2021 Dec 29;13(12):e20807. Epub 2021 Dec 29.

Department of Cardiology, Ehime Prefectural Central Hospital, Matsuyama, JPN.

Understanding the lead trajectory is important in preventing complications after cardiac rhythm device implantation. In this report, we sought to reconstruct the three-dimensional (3D) shape of a pacing lead from radiographs taken at 90-degree angles. All image data were obtained from a 65-year-old male patient, who underwent pacemaker implantation at our hospital due to third-degree atrioventricular block in 2016. Read More

Circ J 2022 Jan 29. Epub 2022 Jan 29.

Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine.

Background: Implanting a ventricular demand leadless pacemaker (VVI-LPM) for patients with non-atrial fibrillation (AF) bradyarrhythmias such as sick sinus syndrome (SSS) or high-grade (i.e., second- or third-degree) atrioventricular (AV) block is not recommended unless they have limited vascular access or a high infection risk; nevertheless, an unexpectedly high number of VVI-LPM implantations have been performed. Read More

Open Vet J 2021 Oct-Dec;11(4):662-666. Epub 2021 Nov 16.

Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.

Background: Third-degree atrioventricular block (AVB) is usually permanent, with transient cases being rare. Cats with transient third-degree AVB. It had been not reported in detail. Read More

Kardiol Pol 2022;80(2):191-197. Epub 2022 Jan 14.

Department of Electrocardiology, Upper-Silesian Medical Center, Katowice, Poland.

Background: Sleep-disordered breathing (SDB) is a risk factor for bradyarrhythmia, which is reversible with positive airway pressure therapy.

Aims: The study aims to evaluate the occurrence and number of severe sinus bradycardia and advanced atrioventricular block (AVB) in patients with cardiovascular diseases and SDB risk factors.

Methods: The analysis covered 207 patients with cardiovascular diseases aged 59. Read More

J Am Heart Assoc 2022 02 8;11(3):e023000. Epub 2022 Jan 8.

The Hospital for Sick Children Toronto Ontario Canada.

Background Transplacental fetal treatment of immune-mediated fetal heart disease, including third-degree atrioventricular block (AVB III) and endocardial fibroelastosis, is controversial. Methods and Results To study the impact of routine transplacental fetal treatment, we reviewed 130 consecutive cases, including 108 with AVB III and 22 with other diagnoses (first-degree/second-degree atrioventricular block [n=10]; isolated endocardial fibroelastosis [n=9]; atrial bradycardia [n=3]). Dexamethasone was started at a median of 22. Read More

Front Cardiovasc Med 2021 21;8:801444. Epub 2021 Dec 21.

Department of Cardiothoracic Surgery, Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Although Fontan palliation seems to be inevitable for many patients with complex congenital heart defects (CHDs), candidates with appropriate conditions could be selected for biventricular conversion. We aimed to summarize our single-center experience in patient selection, surgical strategies, and early outcomes in biventricular conversion for the complex CHD. From April 2017 to June 2021, we reviewed 23 cases with complex CHD who underwent biventricular conversion. Read More

Heart Surg Forum 2021 Dec 28;24(6):E1057-E1064. Epub 2021 Dec 28.

Dalian Women and Children's Medical Group, Dalian, Liaoning Province, China.

Objective: The aim of this study was to explore the efficacy and safety of minimally invasive transthoracic closure (MITC) in treating ventricular septal defect (VSD).

Methods: A total of 252 children with VSD were investigated between August 2013 and March 2015. Their electrocardiographic indices were monitored at different time points (before surgery [T0], immediately after surgery [T1], and 3 days/7 days/1 month/3 months/6 months after surgery [T2-6]) and followed up every year. Read More

J Small Anim Pract 2021 Dec 10. Epub 2021 Dec 10.

Langford Vets Small Animal Referral Hospital, Langford, Bristol BS40 5DU, UK.

A 4-year-old dog presented with lethargy and bradycardia (heart rate 40 bpm). Electrocardiogram diagnosed third-degree atrioventricular block with narrow QRS complexes. An atropine response test did not result in a change of the heart rate. Read More

Cardiol Res Pract 2021 26;2021:8496351. Epub 2021 Nov 26.

Department of Cardiology, Heart Institute, 108 Military Central Hospital, Hanoi, Vietnam.

Introduction: In clinical practice, many cardiovascular symptoms can be caused by arrhythmias that are not detected by electrocardiography (ECG) or 24-48 h Holter ECG monitoring.

Aims: To describe the efficacy and applicability of a new device (Spyder) in detecting cardiac arrhythmias with midterm ECG monitoring.

Methods: A descriptive, prospective study was performed on 26 consecutive patients who underwent midterm ECG monitoring with the novel ECG patch device (Spyder). Read More