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Open Access Rheumatol 2019 25;11:19-31. Epub 2019 Jan 25.

Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India,

In this narrative review, we overview the recent literature on enthesitis-related arthritis (ERA). For the purpose of our review, we searched Scopus for recent articles on this subject from 2013 onward, including some classic older articles for perspective. ERA is a juvenile idiopathic arthritis (JIA) subtype more common in males, associated in a majority with human leucocyte antigen B27. Read More

Medicine (Baltimore) 2019 Feb;98(6):e14406

Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

Rationale: We present a case of high spinal anesthesia after inadvertent injection of local anesthetics and corticosteroids into the subarachnoid space during attempted epidural injection. Cerebrospinal fluid (CSF) lavage is a suitable method for treatment.

Patient Concerns: A 45-year-old woman presented with posterior thigh, leg, and ankle pain for >6 months and was treated with epidural injection. Read More

Asian J Transfus Sci 2018 Jul-Dec;12(2):105-111

Department of Transfusion Medicine, PGIMER, Chandigargh, India.

Background: Plantar fasciitis (PF) a common chronic musculoskeletal pain routinely diagnosed and treated in rehabilitation practices. When conservative management fails in this degenerative disease, local injections of corticosteroids, platelet rich plasma (PRP), botulinum toxin, extracorporeal shockwave therapy, surgical release are used. In our prospective randomized pilot study we compared the regenerative efficacy of Platelet Rich Plasma vs Kinesiotaping with phonophoresis who were resistant to conservative management of PF. Read More

J Bodyw Mov Ther 2019 Jan 1;23(1):122-137. Epub 2018 Jun 1.

Universidad San Jorge, iPhysio Research Group, Campus Universitario, Autov. A23, km 299, 50830, Villanueva de Gállego, Zaragoza, Spain. Electronic address:

Background: Minimally invasive non-surgical techniques have been widely used worldwide to treat musculoskeletal injuries. Of these techniques, injectable pharmaceutical agents are the most commonly employed treatments, with corticosteroids being the most widely used drugs. The aim of this article is to review current scientific evidence as well as the effectiveness of minimally invasive non-surgical techniques, either alone or combined, for the treatment of plantar fasciitis. Read More

Can Assoc Radiol J 2019 Feb;70(1):37-43

Interventional Musculoskeletal Radiology, Clinical Radiology of Oklahoma, Edmond, Oklahoma, USA.

Back pain is the second most common reason for primary-care physician visits after the common cold. New understanding of the spine pathophysiology and biomechanics led to the development of novel injectable biomaterials to treat those pain generators. Although not all biomaterials are currently ready for common use, there is significant interest by the medical community to invest time, resources, and energy to optimize these injectables. Read More

Pain Res Manag 2018 22;2018:7492753. Epub 2018 Nov 22.

Department of Anesthesiology and Reanimation, Republic of Turkey Health Science University, Diyarbakır Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey.

Background: Diagnosis of lumbar facet joint disease is the sum of the combinations consisting of history, physical activity, and diagnostic imaging frequently including computed tomography and magnetic resonance imaging scans. Prevalence of facet-based chronic low back pain is 15-45%. Intra-articular injections with corticosteroid or medial branch block are traditionally used prevalently in the management of chronic low back pain due to lumbar facet joints. Read More

JAMA 2018 12;320(24):2564-2579

Department of Clinical Research, Rottapharm Biotech, Monza, Italy.

Importance: Even though osteoarthritis is a chronic and progressive disease, pharmacological agents are mainly studied over short-term periods, resulting in unclear recommendations for long-term disease management.

Objective: To search, review, and analyze long-term (≥12 months) outcomes (symptoms, joint structure) from randomized clinical trials (RCTs) of medications for knee osteoarthritis.

Data Sources And Study Selection: The databases of MEDLINE, Scopus, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials were searched until June 30, 2018 (MEDLINE alerts through August 31, 2018) for RCTs of patients with knee osteoarthritis that had treatment and follow-up lasting 1 year or longer. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13687

Articular Orthopaedics, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.

Background: The argument on whether extracorporeal shock-wave therapy (ESWT) and corticosteroid injections (CSIs) exert an equivalent pain control or which is the better treatment for plantar fasciitis (PF) in adults remains to be resolved. It is important and necessary to conduct a meta-analysis to make a relatively more credible and overall assessment about which treatment method performs better pain control in treatment of PF in adults.

Methods: From the inception to July 2018, the Embase, PubMed, Web of Science, and Cochrane Library electronic databases were searched for all relevant studies. Read More

J Okla State Med Assoc 2018 Aug-Sep;111(7):712-713

Saint Anthony Hospital. Family Medicine Residency. Oklahoma City, OK.

Clinical Question: In adults with osteoarthritis of the knee, do conservative management methods such as weight reduction, physical therapy, Tai Chi, non-steroidal anti-inflammatory drugs (NSAIDs), and others provide more and longer pain relief and functionality of the knee, as well as overall well-being, when compared to corticosteroid knee injections?

Answer: Yes. Although there are limited head-to-head trials directly comparing each alternative method to corticosteroid injections, overall evidence appears to indicate conservative methods as being more effective than injections, especially when considering long-term pain relief and functionality. Read More

Clin Ophthalmol 2018 19;12:2347-2362. Epub 2018 Nov 19.

S.C.U. Ophthalmology Unit, "City of Health and Science" University Hospital, Department of Surgical Sciences, University of Turin, Turin, Italy,

The main treatment for pterygium is surgical removal. However, pterygium surgery is concerned with high rates of postoperative recurrence. Predicting factors of recurrence are not fully understood, yet, but they probably depend on a multitude of patient-related, clinical, and/or surgical factors. Read More

R I Med J (2013) 2018 Dec 3;101(10):46-50. Epub 2018 Dec 3.

Division of Sports Medicine, Department of Orthopaedic Surgery, Warren Alpert Medical School, Brown University.

Greater Trochanteric Pain Syndrome (GTPS) is a common cause of lateral hip pain, with an incidence of 1.8 per 1000 patients, most commonly occurring between the fourth and sixth decades of life. When GTPS fails to improve with conservative management, hip abductor insufficiency should be suspected. Read More

Handb Clin Neurol 2018 ;158:431-442

Departments of Rehabilitation Medicine, Orthopaedics and Sports Medicine, and Neurological Surgery, University of Washington, Seattle, WA, United States.

Corticosteroid, hyaluronic acid, and platelet-rich plasma injections are commonly utilized when managing pain and injury in the athlete. Although there is ample scientific literature on these injection types, there is a paucity of evidence guiding the use of any of these modalities in a younger, athletic population. Injection strategies should be used as just one aspect of a detailed and athlete-specific return to sport and rehabilitation plan. Read More

BMC Complement Altern Med 2018 Nov 26;18(1):310. Epub 2018 Nov 26.

Department of Medical Rehabilitation, Faculty of Health Sciences and Technology, University of Nigeria|, Enugu Campus, Enugu State, Nigeria.

Background: Many studies on transcutaneous electrical nerve stimulation (TENS) had been undertaken to explore its pain relieving efficiency on several medicals/surgical conditions but none, specifically, had been carried out to determine the effect it has on post-injection sciatic pain (PISP) which comes about from wrong administration of intramuscular pain. This study aims to assess the effects of TENS in the management of PISP.

Methods: A total of 72 PISP subjects comprising 40 test subjects and 32 control subjects participated in a non-randomized controlled clinical trial in the current study. Read More

J Ultrason 2018 ;18(74):234-239

Oxford University and St Lukes Radiology Oxford Ltd, Oxford, UK.

Diagnosis is crucial in decision-making when treating a patient with shoulder pain. Ultrasound is also very important in the diagnostic and therapeutic pathway, especially when surgery is being considered. This article outlines the diagnostic pathway using the patient's history, physical examination and ultrasound examination. Read More

Medicine (Baltimore) 2018 Nov;97(45):e13127

Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Namku, Taegu, Republic of Korea.

Rationale: Although various oral medications and procedures are applied for managing migraine, their efficacy remains limited. To control migraine that does not respond to conventional treatments, we conducted pulsed radiofrequency (PRF) stimulation to the greater occipital nerve (GON) in 2 patients.

Patient Concerns: Patients 1 and 2 complained of chronic throbbing, pulsating, and tight headaches. Read More

Medicine (Baltimore) 2018 Nov;97(44):e13049

Department of Orthopedics, Second Affiliated Hospital of the Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine.

Background: Knee osteoarthritis (KOA) is a progressive joint disease involving intraarticular and periarticular structures. In recent years, there has been increasing interest in the use of autologous growth factors, such as intraarticular injections of platelet-rich plasma (PRP), to treat KOA. It is necessary to update the research and reevaluate the efficacy and safety of PRP to provide up-to-date evidence for KOA management. Read More

PM R 2018 Oct 24. Epub 2018 Oct 24.

Department of Structural Biology and Anatomy, Department of Physical Medicine and Rehabilitation, 1300 Morris Park Avenue, Bronx, NY 10461.

Background: Neck pain is one of the most common causes of chronic pain and the fourth leading cause of disability worldwide; it is estimated that between 36% to 67% of this pain is due to facet arthropathy. For patients who have pain refractory to conservative treatments literature supports management with diagnostic cervical medial branch blocks (cMBBs) to identify the associated facet innervation as the source of pain followed by therapeutic radiofrequency ablation (RFA) of the identified nerves. Cervical RFA has good published outcomes, but the procedure is dependent upon the specificity of the diagnostic block to achieve maximal success. Read More

BMC Vet Res 2018 Oct 23;14(1):318. Epub 2018 Oct 23.

Department of Pathobiology, University of Guelph, 50 Stone Road E, Guelph, ON, N1G 2W1, Canada.

Background: Surgical castration is a painful procedure, performed routinely on commercial pig farms to prevent boar taint and reduce aggression. The objectives of this study were to assess the efficacy of 0.04 mg/kg buprenorphine (BUP) in reducing pain in castrated piglets, using behavioral indicators and vocalization analysis. Read More

Taiwan J Obstet Gynecol 2018 Oct;57(5):654-658

Department of Obstetrics and Gynecology, Nowon Eulji Medical Center, Eulji University, Seoul, Republic of Korea. Electronic address:

Objective: Although laparoscopic hysterectomy, a worldwide popular surgery, ensures faster recovery and less postoperative pain than with laparotomic hysterectomy, immediate pain control still improving postoperative care. We introduce an effective method, intraoperative injection of ropivacaine into both uterosacral ligaments, to control immediate postoperative pain.

Materials And Methods: We performed a prospective, double-blind, and randomized study. Read More

Medicine (Baltimore) 2018 Oct;97(41):e12791

Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

A previous study showed that transforaminal balloon adhesiolysis via the safe triangle was effective in lumbar spinal stenosis. However, retrodiscal pathology is difficult to treat with this method. Therefore we attempted retrodiscal balloon adhesiolysis via Kambin's triangle. Read More

Pain Manag 2018 Sep 3;8(5):321-326. Epub 2018 Oct 3.

Department of Physical Medicine & Rehabilitation, Gulhane School of Medicine, University of Health Science, Ankara 06100, Turkey.

Aim: To investigate the long-term effect of fluoroscopy guided cervical transforaminal epidural steroid injection on neck pain radiating to the arm due to cervical disc herniation.

Materials & Methods: 64 patients (26 women [40.6%], 38 men [59. Read More

BMC Musculoskelet Disord 2018 Sep 27;19(1):349. Epub 2018 Sep 27.

Department of Health Services Policy and Management, University of South Carolina, Columbia, SC, USA.

Background: In this paper we investigate patients seeking care for a new diagnosis of shoulder osteoarthritis (OA) and the association between a patient's initial physician specialty choice and one-year surgical and conservative treatment utilization.

Methods: Using retrospective data from a single large regional healthcare system, we identified 572 individuals with a new diagnosis of shoulder OA and identified the specialty of the physician which was listed as the performing physician on the index shoulder visit. We assessed treatment utilization in the year following the index shoulder visit for patients initiating care with a non-orthopaedic physician (NOP) or an orthopaedic specialist (OS). Read More

Acta Chir Orthop Traumatol Cech 2018 ;85(4):261-265

Ortopedicko-traumatologické oddělení, Nemocnice Znojmo.

PURPOSE OF THE STUDY This study aimed to explore the effects of new therapeutic procedures in patients with shoulder impingement syndrome. The primary goal of the study was to confirm the hypothesis that the application of the platelet-rich plasma (PRP) in patients with shoulder impingement syndrome will have a positive effect on both the subjective and objective evaluation of their condition. The clinical condition before and after the treatment was evaluated. Read More

Medicine (Baltimore) 2018 Sep;97(38):e12388

Department of Pain Management, West China Hospital, Sichuan University, Chengdu, China.

Rationale: Effective treatments for trigeminal nerve postherpetic neuralgia (PHN) are limited. Adriamycin (doxorubicin) has been applied to the treatment of neuropathic pain. This study reports a new treatment: Adriamycin injected to Gasserian ganglion for an elderly patient with the intractable trigeminal nerve PHN. Read More

J Orthop Sci 2018 Sep 29;23(5):801-806. Epub 2018 Jun 29.

Department of Orthopedic Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.

Background: The efficacy of morphine added to periarticular multimodal drug injection (PMDI) for pain management after total knee arthroplasty (TKA) is controversial. Adding morphine to spinal anesthesia has reportedly improved pain relief for the first 24 h. We examined the effect of morphine added to PMDI or spinal anesthesia on pain management and functional recovery after TKA. Read More

Medicine (Baltimore) 2018 Sep;97(37):e12389

Touro College of Osteopathic Medicine, New York.

Rationale: Perineural cysts, commonly referred to as Tarlov cysts, are cerebrospinal fluid-filled dilations between the perineurium and endoneurium typically arising at the junction of posterior and dorsal root ganglia in the neural foramina. This anatomical location is in close proximity to usual needle trajectory during performing transforaminal epidural injection, and therefore presents a potential risk of dural puncture and associated complications.

Patient Concerns: Severe lower extremity pain interfering with activities of daily living. Read More

Plast Reconstr Surg 2018 Dec;142(6):862e-871e

Pittsburgh, Pa. From the Department of Plastic Surgery, University of Pittsburgh.

Background: By age 60, 30 percent of Americans suffer from fat pad atrophy of the foot. Forefoot fat pad atrophy results from long-term aggressive activity, genetically dictated foot type, multiple forefoot steroid injections, surgery, and foot trauma.

Methods: The authors present data from a 2-year, prospective, randomized crossover study performed to assess pain and disability indexes, fat pad thickness, forces, and pressures of stance and gait. Read More

Mol Pain 2018 Jan-Dec;14:1744806918803039. Epub 2018 Sep 10.

3 Research Center for Medicine and Biology, Zunyi Medical University, Zunyi, Guizhou, China.

Background Cancer pain is a well-known serious complication in metastatic or terminal cancer patients. Current pain management remains unsatisfactory. The activation of spinal and supraspinal P2X receptors plays a crucial role in the induction and maintenance mechanisms of various kinds of acute or chronic pain. Read More

Acta Ophthalmol 2018 Dec 9;96(8):804-811. Epub 2018 Sep 9.

Regional Research Support, Oslo University Hospital, Oslo, Norway.

Purpose: Studies reporting on patient perspectives during treatment of neovascular age-related macular degeneration (nAMD) are limited. Thus, the aim of this study was to develop and test psychometric performance of a patient-derived questionnaire to capture important experiences during intravitreal treatment.

Methods: Patients (n = 44) with at least 3-month experience of intravitreal injection treatment for nAMD identified the dimensions of priority and also performed a weighting procedure to develop a score for comparison. Read More

Neuropharmacology 2018 10 5;141:238-248. Epub 2018 Sep 5.

Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, 07103, NJ, USA. Electronic address:

Hemorrhages occurring within the thalamus lead to a pain syndrome. Clinical treatment of thalamic pain is ineffective, at least in part, due to the elusive mechanisms that underlie the induction and maintenance of thalamic pain. The present study investigated the possible contribution of a protein-protein interaction between postsynaptic density protein 95 (PSD-95) and neuronal nitric oxide synthase (nNOS) to thalamic pain in mice. Read More

Dis Colon Rectum 2018 Oct;61(10):1205-1216

School of Medicine, The University of Adelaide, Adelaide, South Australia, Australia.

Background: Intraperitoneal local anesthetic is an analgesic technique for inclusion in the polypharmacy approach to postoperative pain management in enhanced recovery after surgery programs. Previously, augmentation of epidural analgesia with intraperitoneal local anesthetic was shown to improve functional postoperative recovery following colectomy.

Objective: This study determines whether intraperitoneal local anesthetic improves postoperative recovery in patients undergoing colectomy, in the absence of epidural analgesia, with standardized enhanced recovery after surgery perioperative care. Read More

BMC Ophthalmol 2018 Sep 5;18(1):238. Epub 2018 Sep 5.

Departments of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.

Background: Endogenous endophthalmitis could lead to a devastating outcome without a prompt and appropriate management. We report a case of advanced endogenous Klebsiella pneumoniae endophthalmitis with extensive subretinal abscess that was successfully treated with a vitrectomy.

Case Presentation: A systemically well 61-year-old man complained of ocular pain and visual decrease in his right eye for eighteen days. Read More

J Shoulder Elbow Surg 2018 Oct 28;27(10):1907-1912. Epub 2018 Aug 28.

Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

Background: Lateral collateral ligament (LCL) insufficiency may occur in patients with chronic lateral epicondylitis (LE). We report on 14 consecutive patients with chronic LE and LCL insufficiency.

Methods: We performed a retrospective review of 14 patients with LE and LCL insufficiency diagnosed between 2006 and 2015. Read More

Int J Surg 2018 Oct 29;58:3-10. Epub 2018 Aug 29.

Department of Bone and Joint, Taizhou People's Hospital, Taizhou, 225300, China. Electronic address:

Objective: Knee osteoarthritis (OA) is a common disease, imposing a great burden through pain and decreased function. Numerous methods have been tested for pain management in knee OA and the optimal method is currently still under debate. We performed a meta-analysis from randomized controlled trials (RCTs) to compare the efficacy and safety of intra-articular hyaluronic acid (HA) and oxygen-ozone in the treatment of knee OA. Read More

Radiography (Lond) 2018 Oct 11;24 Suppl 1:S20-S27. Epub 2018 Jul 11.

Radiography and Diagnostic Imaging, School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address:

Purpose: The production of patient information leaflets (PILs) for diverse patient cohorts is challenging. This study developed varicocele and fluoroscopy guided joint injection (FLGJI) procedural PILs.

Methodology: Evidence-based PILs were developed, providing radiological procedural information - preparation, explanation of interventional procedures and aftercare. Read More

Skeletal Radiol 2018 Dec 28;47(12):1635-1640. Epub 2018 Aug 28.

Department of Orthopaedic Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.

Objective: Our study aimed to determine the duration of pain relief from intraarticular hip corticosteroid injections and identify patient predictive factors on injection response. We also sought to determine the subsequent rate of hip surgery and whether severity of hip osteoarthritis or injection response correlated with the decision to undergo surgery.

Materials And Methods: All intraarticular hip steroid injections performed for osteoarthritis under fluoroscopic guidance at a single institution between January 2010 to December 2012 were retrospectively reviewed. Read More

Pain Res Manag 2018 31;2018:5392538. Epub 2018 Jul 31.

Programa de Pós-Graduação em Patologia, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.

Viscosupplementation is a minimally invasive technique that replaces synovial fluid by intra-articular injection of hyaluronic acid (HA). Although effective in some joints, there is not conclusive evidence regarding temporomandibular disorders. This case series described the efficacy of a viscosupplementation protocol in intra-articular temporomandibular disorders. Read More

Dermatol Surg 2018 Sep;44(9):1191-1200

Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California.

Background: Studies suggest platelet-rich plasma (PRP) may mitigate androgenetic alopecia (AGA), but each varies in the frequency of and interval between treatments.

Objective: To compare the efficacy, satisfaction, tolerability, and safety of 2 initial PRP injection protocols over 6 months.

Methods: Prospective, randomized, single-blinded trial among 40 patients with moderate AGA. Read More

Br Med Bull 2018 Sep;127(1):111-143

Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo, Trigoria, Rome, Italy.

Introduction: Currently, no therapeutic intervention is universally accepted, and the most effective management for restoring motion and diminishing pain in patients with shoulder stiffness has yet to be defined. This systematic review analyses outcomes of conservative and surgical interventions to treat shoulder stiffness.

Source Of Data: A systematic review of literature according to the PRISMA guidelines was performed. Read More

J Pediatr Orthop 2018 Nov/Dec;38(10):e610-e617

Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE.

Background: Many patients with spinal muscular atrophy (SMA) who might benefit from intrathecal antisense oligonucleotide (nusinersen) therapy have scoliosis or spinal fusion that precludes safe drug delivery. To circumvent spinal pathology, we designed a novel subcutaneous intrathecal catheter (SIC) system by connecting an intrathecal catheter to an implantable infusion port.

Methods: Device safety and tolerability were tested in 10 SMA patients (age, 5. Read More

Int Urol Nephrol 2018 Oct 21;50(10):1745-1751. Epub 2018 Aug 21.

Department of Gynecology and Oncology, Collegium Medicum Jagiellonian University of Kraków, Kraków, Poland.

Purpose: Given that more cancers are being diagnosed earlier and that treatment of cancer is improving, health issues of cancer survivors are becoming more common and apparent. Pelvic radiation therapy for the treatment of gynecological cancers can lead to long-term collateral damage to the bladder, a condition termed radiation cystitis (RC). Late sequelae may take many years to develop and include incontinence and pain as well as hematuria. Read More

Curr Opin Anaesthesiol 2018 Dec;31(6):739-748

Department of Anesthesia and Pain Medicine, University of Toronto, University Health Network-Toronto Western Hospital, Toronto, Ontario, Canada.

Purpose Of Review: The purposes of this review are to summarize the advantages and limitations of ultrasound-guided pain interventions, and to illustrate those interventions with peripheral, axial and musculoskeletal pain procedures.

Recent Findings: With the capability of locating the interfascial plane, ultrasonography has led to the emergence of a series of plane blocks for the thoracoabdominal region in the recent decade.Ultrasonography for musculoskeletal procedures has been of growing interest because of the major advantage of direct visualization and scanning of various soft tissues and real-time spread in the injectate, thereby enhancing precision and efficacy, reducing risk of trauma and avoidance of radiation. Read More

J Am Acad Dermatol 2018 09;79(3):423-435

Division of Dermatology, Loyola University Medical Center, Maywood, Illinois.

Injectable fillers and neuromodulators are used for a range of indications pertaining to the correction of facial aging and disfigurement. Fillers can correct soft tissue loss, depressed scars, and atrophy or asymmetry induced by systemic or local disease. Neuromodulators correct muscle-mediated skin creases, reshape the face, and address right-left functional asymmetry. Read More

Lancet 2018 08 13;392(10148):617-619. Epub 2018 Aug 13.

Department of Anaesthesia and Critical Care, University Hospitals of Wuerzburg, 97080 Wuerzburg, Germany.

J Headache Pain 2018 Aug 15;19(1):70. Epub 2018 Aug 15.

The David Geffen School of Medicine at UCLA, 4255 Jefferson Avenue, Suite 27, Woodside, CA, 94062, USA.

Background: DFN-11, a 3 mg sumatriptan subcutaneous (SC) autoinjector for acute treatment of migraine, has not been assessed previously in multiple attacks. The objective of this study was to evaluate the efficacy, tolerability, and safety of DFN-11 in the acute treatment of multiple migraine attacks.

Methods: This was an 8-week open-label extension of multicenter, randomized, double-blind, placebo-controlled US study. Read More

PLoS One 2018 3;13(8):e0201673. Epub 2018 Aug 3.

Departments of Anesthesiology and Oncology, Mayo Clinic, Translational Science Track, Mayo Graduate School, Rochester, MN, United States of America.

Introduction: Osteoarthritis (OA) is the most common form of arthritis. Medical and surgical treatments have yet to substantially diminish the global health and economic burden of OA. Due to recent advances in clinical imaging, including magnetic resonance imaging (MRI), a correlation has been established between structural joint damage and OA-related pain and disability. Read More

Curr Opin Anaesthesiol 2018 Oct;31(5):636-642

NYSORA, Ziekenhuis Oost-Limburg (ZOL), Genk, Belgium.

Purpose Of Review: New formulations of local anesthetics with sustained release and longer duration of action are being developed to improve patient outcomes following surgery. This review summarizes the efficacy and safety of the three most recently developed extended-release formulations of the local anesthetic, bupivacaine.

Recent Findings: Bupivacaine liposome injectable suspension (EXPAREL) encapsulates bupivacaine in biodegradable liposomes. Read More

Reg Anesth Pain Med 2018 Nov;43(8):880-884

From the Department of Anesthesiology, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ.

Background And Objectives: Postdural puncture headache (PDPH) is a severe and debilitating complication of unintentional dural puncture. The criterion-standard treatment for PDPH has been epidural blood patch (EBP), but it is an invasive intervention with the potential for severe complications, such as meningitis and paralysis. We believe this is the first ever 17-year retrospective chart review in which we compare the effectiveness of sphenopalatine ganglion block (SPGB) to EBP for PDPH treatment in postpartum patients. Read More

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Department of Neurosurgery, King's College Hospital NHS Foundation Trust, London, UK.

Myoclonus describes a movement disorder characterised by brief, abrupt and involuntary contractions of muscles or groups of muscles, usually associated with intracranial lesions, with limited evidence linking it to spinal pathologies. The pathophysiology of spinal myoclonus is extensive and multifactorial. Infection, intramedullary and extramedullary space-occupying lesions, trauma, vascular abnormalities, degenerative processes and cervical spondylosis have been implicated with the disease, the latter been associated with cervical stenosis with no reported cases linking it to an underlying cervical disc herniation. Read More