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    Re-examining the arterial cord blood gas pH screening criteria in neonatal encephalopathy.
    Arch Dis Child Fetal Neonatal Ed 2017 Sep 23. Epub 2017 Sep 23.
    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri, USA.
    Objective: Screening criteria for neonatal encephalopathy remain a complex combination of subjective and objective criteria. We examine the utility of universal cord blood gas testing and mandatory encephalopathy evaluation for infants with pH ≤7.10 on umbilical cord arterial blood gas (cABG) as a single screening measure for timely identification of moderate/severe encephalopathy. Read More

    Therapeutic hypothermia in mild neonatal encephalopathy: a national survey of practice in the UK.
    Arch Dis Child Fetal Neonatal Ed 2017 Sep 23. Epub 2017 Sep 23.
    Centre for Perinatal Neuroscience, Department of Paediatrics, Imperial College London, London, London, UK.
    Although major cooling trials (and subsequent guidelines) excluded babies with mild encephalopathy, anecdotal evidence suggests that cooling is often offered to these infants. We report a national survey on current cooling practices for babies with mild encephalopathy in the UK. From 74 neonatal units contacted, 68 were cooling centres. Read More

    Oxidative stress and endoplasmic reticulum (ER) stress in the development of neonatal hypoxic-ischaemic brain injury.
    Biochem Soc Trans 2017 Sep 22. Epub 2017 Sep 22.
    Perinatal Brain Injury Group, Centre for the Developing Brain, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London SE1 7EH, U.K.
    Birth asphyxia in term neonates affects 1-2/1000 live births and results in the development of hypoxic-ischaemic encephalopathy with devastating life-long consequences. The majority of neuronal cell death occurs with a delay, providing the potential of a treatment window within which to act. Currently, treatment options are limited to therapeutic hypothermia which is not universally successful. Read More

    Hypothermia induced by anesthesia regulates various signals expressions in the hippocampus of animals.
    Biomed Pharmacother 2017 Sep 18;95:1321-1330. Epub 2017 Sep 18.
    Department of Anesthesiology, Huaiyin Hospital of Huaian City, 38 Beijing Road West, Huai'an, Jiangsu, 223300, China. Electronic address:
    Though important for a variety of medical procedures, general anesthesia is not a problem free. Some anesthetics have been suggested to affect a number of signals, which are associated with memory consolidation and cognition. In the present study, we attempted to investigate the molecular mechanism of anesthesia-regulated processes. Read More

    Feasibility and Safety of Controlled Active Hypothermia Treatment During Transport in Neonates With Hypoxic-Ischemic Encephalopathy.
    Pediatr Crit Care Med 2017 Sep 21. Epub 2017 Sep 21.
    11st Department of Paediatrics, Semmelweis University, Budapest, Hungary. 2Neonatal Emergency & Transport Services of Peter Cerny Foundation, Budapest, Hungary. 3MTA-SE Pediatric and Nephrology Research Group, Budapest, Hungary.
    Objectives: To evaluate the feasibility and safety of controlled active hypothermia versus standard intensive care during neonatal transport in patients with hypoxic-ischemic encephalopathy.

    Design: Cohort study with a historic control group.

    Setting: All infants were transported by Neonatal Emergency & Transport Services to a Level-III neonatal ICU. Read More

    Residual brain injury after early discontinuation of cooling therapy in mild neonatal encephalopathy.
    Arch Dis Child Fetal Neonatal Ed 2017 Sep 21. Epub 2017 Sep 21.
    Centre for Perinatal Neuroscience, Imperial College London, London, UK.
    We examined the brain injury and neurodevelopmental outcomes in a prospective cohort of 10 babies with mild encephalopathy who had early cessation of cooling therapy. All babies had MRI and spectroscopy within 2 weeks after birth and neurodevelopmental assessment at 2 years. Cooling was prematurely discontinued at a median age of 9 hours (IQR 5-13) due to rapid clinical improvement. Read More

    Enhanced pyruvate dehydrogenase activity improves cardiac outcomes in a murine model of cardiac arrest.
    PLoS One 2017 21;12(9):e0185046. Epub 2017 Sep 21.
    Section of Emergency Medicine; Department of Medicine, University of Chicago, Chicago, Illinois, United States of America.
    Rationale: Post-ischemic changes in cellular metabolism alter myocardial and neurological function. Pyruvate dehydrogenase (PDH), the limiting step in mitochondrial glucose oxidation, is inhibited by increased expression of PDH kinase (PDK) during ischemia/reperfusion injury. This results in decreased utilization of glucose to generate cellular ATP. Read More

    Serum copeptin and neuron specific enolase are markers of neonatal distress and long-term neurodevelopmental outcome.
    PLoS One 2017 20;12(9):e0184593. Epub 2017 Sep 20.
    Department of Biosciences, University of Helsinki, Helsinki, Finland.
    The objective of this study was to evaluate the early changes in serial serum levels of copeptin and neuron-specific enolase (NSE) in neonates diagnosed with birth asphyxia, and to determine whether these biomarkers measured in the first 168 hours after birth are predictive of long-term neurodevelopmental outcome. Copeptin and NSE levels were measured from serum samples collected 6, 12, 24, 48, 72, and 168 hours after birth from 75 term neonates diagnosed with hypoxic-ischemic encephalopathy (HIE) and treated with therapeutic hypothermia for 72 hours. In addition, serum copeptin levels after birth were measured from 10 HIE diagnosed neonates, who were randomized to the normothermic arm of the TOBY cohort. Read More

    Neuroprotection with hypothermia and allopurinol in an animal model of hypoxic-ischemic injury: Is it a gender question?
    PLoS One 2017 20;12(9):e0184643. Epub 2017 Sep 20.
    Department of Neonatology, BCNatal, Sant Joan de Déu-Hospital Clínic, Barcelona, Spain.
    Background: Hypoxic-ischemic encephalopathy (HIE) is one of the most important causes of neonatal brain injury. Therapeutic hypothermia (TH) is the standard treatment for term newborns after perinatal hypoxic ischemic injury (HI). Despite this, TH does not provide complete neuroprotection. Read More

    Hypothermia increases aquaporin 4 (AQP4) plasma membrane abundance in human primary cortical astrocytes via a calcium/ transient receptor potential vanilloid 4 (TRPV4)- and calmodulin-mediated mechanism.
    Eur J Neurosci 2017 Sep 19. Epub 2017 Sep 19.
    Research Institute of Health Sciences, Wolverhampton School of Sciences, University of Wolverhampton, Wulfruna St, Wolverhampton, WV1 1LY.
    Human aquaporin 4 (AQP4) is the primary water channel protein in brain astrocytes. Hypothermia is known to cause astrocyte swelling in culture, but the precise role of AQP4 in this process is unknown. Primary human cortical astrocytes were cultured under hypothermic (32°C) or normothermic (37°C) conditions. Read More

    Prognostic Value of Brain Magnetic Resonance Imaging in Neonatal Hypoxic-Ischemic Encephalopathy: A Meta-analysis.
    J Child Neurol 2017 Jan 1:883073817726681. Epub 2017 Jan 1.
    5 Division of Neuroradiology and Pediatric Radiology, Department of Radiology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
    Objective: To quantify the prognostic value of neonatal brain magnetic resonance imaging (MRI) in neonatal hypoxic-ischemic encephalopathy.

    Methods: Meta-analysis of studies with ≥35-week neonates with hypoxic-ischemic encephalopathy who underwent brain MRI within age 4 weeks and had neurodevelopmental follow-up for at least 12 months.

    Results: An abnormal neonatal brain MRI was more frequent among patients with unfavorable neurodevelopmental outcome: odds ratio = 18. Read More

    Hypothermia for encephalopathy in low and middle-income countries (HELIX): study protocol for a randomised controlled trial.
    Trials 2017 Sep 18;18(1):432. Epub 2017 Sep 18.
    Neonatal-Perinatal Medicine, Wayne State University, Detroit, MI, USA.
    Background: Therapeutic hypothermia reduces death and disability after moderate or severe neonatal encephalopathy in high-income countries and is used as standard therapy in these settings. However, the safety and efficacy of cooling therapy in low- and middle-income countries (LMICs), where 99% of the disease burden occurs, remains unclear. We will examine whether whole body cooling reduces death or neurodisability at 18-22 months after neonatal encephalopathy, in LMICs. Read More

    Registry study to assess hair loss prevention with the Penguin Cold Cap in breast cancer patients receiving chemotherapy.
    Breast Cancer Res Treat 2017 Sep 18. Epub 2017 Sep 18.
    Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, 1600 Divisadero St, San Francisco, CA, 94115, USA.
    Purpose: Chemotherapy-induced alopecia is a distressing side effect of cancer treatment. The aim of this registry study was to assess efficacy and tolerability of scalp hypothermia using Penguin Cold Caps (Penguin) in breast cancer patients.

    Methods: Hair loss was assessed by patients using a 100-point Visual Analog Scale (VAS) and by physicians using the 5-point Dean Scale at baseline, every 3-4 weeks during chemotherapy, and at least 1 month after completion of chemotherapy. Read More

    Trace amine-associated receptor 1 regulation of methamphetamine-induced neurotoxicity.
    Neurotoxicology 2017 Sep 14. Epub 2017 Sep 14.
    Research Service, VA Portland Health Care System, Portland, OR, USA; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA; The Methamphetamine Abuse Research Center, Oregon Health & Science University, Portland, OR, USA; Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA. Electronic address:
    Trace amine-associated receptor 1 (TAAR1) is activated by methamphetamine (MA) and modulates dopaminergic (DA) function. Although DA dysregulation is the hallmark of MA-induced neurotoxicity leading to behavioral and cognitive deficits, the intermediary role of TAAR1 has yet to be characterized. To investigate TAAR1 regulation of MA-induced neurotoxicity, Taar1 transgenic knock-out (KO) and wildtype (WT) mice were administered saline or a neurotoxic regimen of 4 i. Read More

    Quantification of Induced Hypothermia from Aseptic Scrub Applications during Rodent Surgery Preparation.
    J Am Assoc Lab Anim Sci 2017 Sep;56(5):562-569
    Campus Animal Resources, Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan;, Email:
    Laboratory mice (Mus musculus) are prone to develop hypothermia during anesthesia for surgery, thus potentially impeding anesthetic recovery, wound healing, and future health. The core body temperatures of isoflurane-anesthetized mice are influenced by the choice of supplemental heat sources; however, the contribution of various surgical scrubs on the body temperatures of mice under gas anesthesia has not been assessed. We sought to quantify the effect of using alcohol (70% isopropyl alcohol [IPA]) compared with saline to rinse away surgical scrub on the progression of hypothermia in anesthetized mice (n = 47). Read More

    Moderate hypothermia induces protein SUMOylation in bone marrow stromal cells and enhances their tolerance to hypoxia.
    Mol Med Rep 2017 Sep 5. Epub 2017 Sep 5.
    Department of Neurology, The Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China.
    Acute cerebral infarction can progress rapidly, and there are limited specific and effective treatments. Small ubiquitin‑like modifiers (SUMOs) provide an important post‑translational modification of proteins. Following cerebral infarction, multiple proteins can combine with SUMOs to protect nerve cells. Read More

    Cerebral Tissue Oxidative Ischemia-Reperfusion Injury in Connection with Experimental Cardiac Arrest and Cardiopulmonary Resuscitation: Effect of Mild Hypothermia and Methylene Blue.
    Mol Neurobiol 2017 Sep 11. Epub 2017 Sep 11.
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University, S-75185, Uppsala, Sweden.
    The present investigation is an expansion of previous studies which all share a basic experimental protocol of a porcine-induced cardiac arrest (CA) of 12 min followed by 8 min of cardiopulmonary resuscitation (CPR), different experimental treatments (immediate as well as postponed induced mild hypothermia and administration of much or less cool intravenous fluids), and a follow-up period of 3 h after which the animals were sacrificed. Another group of animals was studied according to the same protocol after 12-min CA and "standard CPR." After death (within 1 min), the brains were harvested and frozen in liquid nitrogen awaiting analysis. Read More

    Prenatal alcohol exposure enhances the susceptibility to NMDA-induced generalized tonic-clonic seizures in developing rats.
    CNS Neurosci Ther 2017 Oct;23(10):808-817
    Department of Pediatrics, Georgetown University Medical Center, Washington, DC, USA.
    Aims: Prenatal alcohol exposure (PAE) is associated with a higher likelihood of developing generalized tonic-clonic seizures (GTCS) in infants and children. However, experimental studies of PAE-related seizures have yielded conflicting results. Here, we investigated the effect of acute PAE on N-methyl-D-aspartate (NMDA)-induced seizures in developing rats. Read More

    Enhanced efficacy of the engineered antimicrobial peptide WLBU2 via direct airway delivery in a murine model of P. aeruginosa pneumonia.
    Clin Microbiol Infect 2017 Sep 4. Epub 2017 Sep 4.
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA; USA. Electronic address:
    Objectives: P. aeruginosa is a common cause of pneumonia in cystic fibrosis patients with the property to generate multidrug resistance against clinically used antibiotics. Antimicrobial peptides (AMPs) are a diverse group of effector molecules of the innate immunity that protect the host against pathogens. Read More

    [Drowning-induced hyperfibrinolytic disseminated intravascular coagulation].
    Ugeskr Laeger 2017 Aug;179(35)
    This article summarizes the current knowledge of drowning-induced hyperfibrinolytic disseminated intravascular coagulation. Drowning induces respiratory failure with ensuing cardiac arrest, hypoxaemia and ischaemia. A coagulopathy is induced by ischaemia, acidosis and hypothermia, and clinically the patient develops uncontrolled bleeding due to hyperfibrinolysis. Read More

    AACE Clin Case Rep 2016 ;2(4):e351-e357
    Division of Endocrinology, Diabetes, and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York, New York.
    Objective: Anorexia nervosa (AN) is a serious disorder with associated morbidity and mortality, most commonly diagnosed in females. Existing literature on male anorexia is sparse, and a review of the endocrine effects of AN in males has not previously been published. Our objective is to highlight the clinical characteristics of AN in males as a routinely overlooked cause of multiple endocrinopathies and systemic illness in hospitalized patients. Read More

    [Revelation of the circumstances of the accident vascular arterial ischemic brain in at term or near-term and referral].
    Arch Pediatr 2017 Sep;24(9S):9S12-9S18
    AP-HP, SMUR pédiatrique, pôle Femmes-Adolescents-Mères-Enfants, Hôpital Antoine-Béclère, 157, rue de la Porte-de-Trivaux, Clamart, 92141 France. Electronic address:
    The neonatal arterial ischemic stroke is an emergency. Recurrent focal seizures, generally occurring in the first 24-72 hours after birth, are the commonest first clinical signs. When neonatal arterial ischemic stroke is suspected, optimal initial management involves careful supportive care including treatment of clinical and frequent or prolonged subclinical seizures, correction of the possible metabolic disorders and their prevention. Read More

    Brain Temperature Is Increased During the First Days of Life in Asphyxiated Newborns: Developing Brain Injury Despite Hypothermia Treatment.
    AJNR Am J Neuroradiol 2017 Aug 31. Epub 2017 Aug 31.
    From the Department of Pediatrics, Division of Newborn Medicine, Research Institute of the McGill University Health Centre (Z.P.O., P.W.), and Department of Pediatric Radiology (C.S.-M.), Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada; and MR Clinical Science (G.G.), Philips Healthcare, Montreal, Quebec, Canada.
    Background And Purpose: Therapeutic hypothermia is the current treatment for neonates with hypoxic-ischemic encephalopathy. It is believed to work by decreasing the brain temperature and reducing the baseline metabolism and energy demand of the brain. This study aimed to noninvasively assess brain temperature during the first month of life in neonates with hypoxic-ischemic encephalopathy treated with hypothermia. Read More

    Continuous versus intermittent neuromuscular blockade in patients during targeted temperature management after resuscitation from cardiac arrest-A randomized, double blinded, double dummy, clinical trial.
    Resuscitation 2017 Aug 30;120:14-19. Epub 2017 Aug 30.
    Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria. Electronic address:
    Aim Of The Study: Current guidelines recommend targeted temperature management to improve neurological outcome after cardiac arrest. Evidence regarding an ideal sedative/analgesic regimen including skeletal muscle paralysis is limited.

    Methods: Patients were randomized to either a continuous administration of rocuronium (continuous-NMB-group) or to a continuous administration of saline supplemented by rocuronium bolus administration if demanded (bolus-NMB-group). Read More

    Troponin-T as a biomarker in neonates with perinatal asphyxia.
    J Neonatal Perinatal Med 2017 Aug 23. Epub 2017 Aug 23.
    Department of Neonatologya, Christian Medical College, Vellore, Tamil Nadu, India.
    Background: Troponin-T is a commonly used cardiac biomarker, which could be useful in perinatal asphyxia. We aimed to analyze troponin-T concentrations in asphyxiated neonates and to correlate the concentrations with clinical outcomes.

    Methods: Data were collected from electronic medical records of neonates diagnosed with perinatal asphyxia over a period of four years. Read More

    Deletion of Nampt in Projection Neurons of Adult Mice Leads to Motor Dysfunction, Neurodegeneration, and Death.
    Cell Rep 2017 Aug;20(9):2184-2200
    Department of Bioengineering, University of Missouri, Columbia, MO 65211, USA; Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, USA. Electronic address:
    Intracellular nicotinamide phosphoribosyltransferase (iNAMPT) is the rate-limiting enzyme of the mammalian NAD(+) biosynthesis salvage pathway. Using inducible and conditional knockout (cKO) mice, we show that Nampt gene deletion in adult projection neurons leads to a progressive loss of body weight, hypothermia, motor neuron (MN) degeneration, motor function deficits, paralysis, and death. Nampt deletion causes mitochondrial dysfunction, muscle fiber type conversion, and atrophy, as well as defective synaptic function at neuromuscular junctions (NMJs). Read More

    The Use of Whole Body Cooling in the Treatment of Hypoxic-Ischemic Encephalopathy.
    Neonatal Netw 2017 Sep;36(5):273-279
    Hypoxic-ischemic encephalopathy (HIE) is a major cause of morbidity and mortality in neonates. Hypoxic-ischemic encephalopathy occurs as a result of a perinatal hypoxic-ischemic event just prior to or during delivery. Therapeutic hypothermia using whole body cooling is the current treatment of choice to reduce brain injury and improve long-term neurodevelopmental outcomes for neonates with HIE. Read More

    Early detection of brain death using the Bispectral Index (BIS) in patients treated by extracorporeal cardiopulmonary resuscitation (E-CPR) for refractory cardiac arrest.
    Resuscitation 2017 Aug 24;120:8-13. Epub 2017 Aug 24.
    Intensive Care Unit, Anesthesiology Department and SAMU of Paris, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris Descartes University, Paris, France. Electronic address:
    Background: Despite increasing use of extracorporeal cardiopulmonary resuscitation (E-CPR) for treatment of refractory cardiac arrest patients, prognosis remains dismal, often resulting in brain-death. However, clinical assessment of brain-death occurence is difficult in post-cardiac arrest patients, sedated, paralyzed, under mild therapeutic hypothermia (MTH). Our objective was to assess the usefulness of Bispectral-Index (BIS) monitoring at bedside for an early detection of brain-death occurrence in refractory cardiac arrest patients treated by E-CPR. Read More

    Targeting Sentinel Proteins and Extrasynaptic Glutamate Receptors: a Therapeutic Strategy for Preventing the Effects Elicited by Perinatal Asphyxia?
    Neurotox Res 2017 Aug 26. Epub 2017 Aug 26.
    Department of Neuroscience, Faculty of Medicine, University of Chile, Santiago, Chile.
    Perinatal asphyxia (PA) is a relevant cause of death at the time of labour, and when survival is stabilised, associated with short- and long-term developmental disabilities, requiring inordinate care by health systems and families. Its prevalence is high (1 to 10/1000 live births) worldwide. At present, there are few therapeutic options, apart from hypothermia, that regrettably provides only limited protection if applied shortly after the insult. Read More

    [Preclinical use of mild therapeutic hypothermia after cardiac arrest by the emergency services in Baden-Württemberg, Germany].
    Med Klin Intensivmed Notfmed 2017 Aug 25. Epub 2017 Aug 25.
    Universitäts-Notfallzentrum, Universitätsklinikum Freiburg, Sir-Hans-A.-Krebsstraße, 79106, Freiburg, Deutschland.
    Background: During the last decade target temperature management has become an integral part of postresuscitation care. Within recent years there was a strong debate about the optimal target temperature, which might have effects on the preclinical induction of hypothermia. The present investigation focuses on the use of mild therapeutic hypothermia by emergency services in the state of Baden-Württemberg (Germany) and compares it to results of a prior study in 2008. Read More

    Retinal cell death dependent reactive proliferative gliosis in the mouse retina.
    Sci Rep 2017 Aug 25;7(1):9517. Epub 2017 Aug 25.
    TU Dresden, Center for Regenerative Therapies Dresden (CRTD), Fetscherstr, 105, 01307, Dresden, Germany.
    Neurodegeneration is a common starting point of reactive gliosis, which may have beneficial and detrimental consequences. It remains incompletely understood how distinctive pathologies and cell death processes differentially regulate glial responses. Müller glia (MG) in the retina are a prime model: Neurons are regenerated in some species, but in mammals there may be proliferative disorders and scarring. Read More

    Neuroendocrine Modulation of IL-27 in Macrophages.
    J Immunol 2017 Oct 23;199(7):2503-2514. Epub 2017 Aug 23.
    Center for Thrombosis and Hemostasis, University Medical Center, Johannes Gutenberg University Mainz, 55131 Mainz, Germany;
    Heterodimeric IL-27 (p28/EBV-induced gene 3) is an important member of the IL-6/IL-12 cytokine family. IL-27 is predominantly synthesized by mononuclear phagocytes and exerts immunoregulatory functional activities on lymphocytic and nonlymphocytic cells during infection, autoimmunity or neoplasms. There is a great body of evidence on the bidirectional interplay between the autonomic nervous system and immune responses during inflammatory disorders, but so far IL-27 has not been defined as a part of these multifaceted neuroendocrine networks. Read More

    Cold-Inducible Protein RBM3 Protects UV Irradiation-Induced Apoptosis in Neuroblastoma Cells by Affecting p38 and JNK Pathways and Bcl2 Family Proteins.
    J Mol Neurosci 2017 Aug 22. Epub 2017 Aug 22.
    School of Life Science and Technology, Xinxiang Medical University, 601 Jinsui Road, Xinxiang, Henan, 453003, China.
    Induced by hypothermia, cold-inducible protein RBM3 (RNA-binding protein motif 3), has been implicated in neuroprotection against various toxic insults such as hypoxia and ischemia. However, whether mild hypothermia and RBM3 prevent neural cells from UV irradiation-elicited apoptosis is unclear. In the present study, human neuroblastoma cell line SH-SY5Y was used as a cell model for neural cell death, and it was demonstrated that mild hypothermia protects SH-SY5Y cells from UV irradiation-induced apoptosis. Read More

    Therapeutic hypothermia for ischemic stroke; pathophysiology and future promise.
    Neuropharmacology 2017 Aug 19. Epub 2017 Aug 19.
    Department of Neurology, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, CA 94121, USA. Electronic address:
    Therapeutic hypothermia, or cooling of the body or brain for the purposes of preserving organ viability, is one of the most robust neuroprotectants at both the preclinical and clinical levels. Although therapeutic hypothermia has been shown to improve outcome from related clinical conditions, the significance in ischemic stroke is still under investigation. Numerous pre-clinical studies of therapeutic hypothermia has suggested optimal cooling conditions, such as depth, duration, and temporal therapeutic window for effective neuroprotection. Read More

    Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction.
    Proc Natl Acad Sci U S A 2017 Sep 21;114(36):9731-9736. Epub 2017 Aug 21.
    Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037;
    When food resources are scarce, endothermic animals can lower core body temperature (Tb). This phenomenon is believed to be part of an adaptive mechanism that may have evolved to conserve energy until more food becomes available. Here, we found in the mouse that the insulin-like growth factor 1 receptor (IGF-1R) controls this response in the central nervous system. Read More

    Efficacy of passive hypothermia and adverse events during transport of asphyxiated newborns according to the severity of hypoxic-ischemic encephalopathy.
    J Pediatr (Rio J) 2017 Aug 18. Epub 2017 Aug 18.
    Institut de Recerca Pediatrica Sant Joan de Déu, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain; Fundación NeNe, Spain; Universitat de Barcelona, Barcelona, Spain; CIBER de Enfermedades Raras (CIBERER), U724, Madrid, Spain. Electronic address:
    Objective: To determine if the efficacy of passive hypothermia and adverse events during transport are related to the severity of neonatal hypoxic-ischemic encephalopathy.

    Methods: This was a retrospective study of 67 infants with hypoxic-ischemic encephalopathy, born between April 2009 and December 2013, who were transferred for therapeutic hypothermia and cooled during transport.

    Results: Fifty-six newborns (84%) were transferred without external sources of heat and 11 (16%) needed an external heat source. Read More

    Reversal of Spinal Cord Ischemia Following Endovascular Thoracic Aortic Aneurysm Repair With Hyperbaric Oxygen and Therapeutic Hypothermia.
    Vasc Endovascular Surg 2017 Oct 18;51(7):517-520. Epub 2017 Aug 18.
    5 Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
    Background: Neurological adverse events with spinal cord ischemia (SCI) remain one of the most feared complications in patients undergoing thoracic endovascular aortic repair (TEVAR). These patients can develop irreversible paraplegia with lifelong consequences with physical and psychological agony.

    Case Presentation: We herein present a patient who developed SCI with bilateral lower leg paraplegia on the third postoperative day following TEVAR. Read More

    Dextran sodium sulfate (DSS) induces necrotizing enterocolitis-like lesions in neonatal mice.
    PLoS One 2017 17;12(8):e0182732. Epub 2017 Aug 17.
    Department of Pediatric Surgery, University of Leipzig, Leipzig, Germany.
    Background: Necrotizing enterocolitis (NEC) is an inflammatory bowel disease of preterm human newborns with yet unresolved etiology. An established neonatal murine model for NEC employs oral administration of lipopolysaccharides (LPS) combined with hypoxia/hypothermia. In adult mice, feeding dextran sodium sulfate (DSS) represents a well-established model for experimental inflammatory bowel disease. Read More

    Modeling hypothermia induced effects for the heterogeneous ventricular tissue from cellular level to the impact on the ECG.
    PLoS One 2017 16;12(8):e0182979. Epub 2017 Aug 16.
    Institute of Electrical and Biomedical Engineering, UMIT-University for Health Sciences, Medical Informatics and Technology, Hall, Tyrol, Austria.
    Hypothermia has a profound impact on the electrophysiological mechanisms of the heart. Experimental investigations provide a better understanding of electrophysiological alterations associated with cooling. However, there is a lack of computer models suitable for simulating the effects of hypothermia in cardio-electrophysiology. Read More

    Plasma Glycoproteomic Study of Therapeutic Hypothermia Reveals Novel Markers Predicting Neurologic Outcome Post-cardiac Arrest.
    Transl Stroke Res 2017 Aug 15. Epub 2017 Aug 15.
    Clinical Proteomics Research Center and Cardio-Neurology Clinic, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 175 Cambridge St, Suite 340, Boston, MA, 02114, USA.
    Therapeutic hypothermia (TH) is a neuroprotective treatment post-cardiac arrest but is grossly underutilized. After TH induction, traditional biomarkers and parameters can no long predict clinical outcome due to a lack of understanding of hypothermic response. Innovative approaches to better understand the clinical effect of TH will help to prognosticate outcome and expand beneficial population. Read More

    The use of phenobarbital and other anti-seizure drugs in newborns.
    Semin Fetal Neonatal Med 2017 Oct 12;22(5):321-327. Epub 2017 Aug 12.
    Fetal-Neonatal Neurology Program, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
    Neonatal seizures constitute the most frequent presenting neurologic sign encountered in the neonatal intensive care unit. Despite limited efficacy and safety data, phenobarbital continues to be used near-universally as the first-line anti-seizure drug (ASD) in neonates. The choice of second-line ASDs varies by provider and institution, and is still not supported by sufficient scientific evidence. Read More

    Age is related to neurological outcome in patients with out-of-hospital cardiac arrest (OHCA) receiving therapeutic hypothermia (TH).
    Am J Emerg Med 2017 Jul 29. Epub 2017 Jul 29.
    Department of Emergency Medicine, Gachon University Gil Medical Center, Incheon, South Korea. Electronic address:
    Introduction: In this study, we retrospectively reviewed the patients' outcomes after cardiac arrest based on age in one center, to determine whether geriatric patients had worse outcomes.

    Methods: This was a single-center, retrospective cohort study. The patients admitted to the intensive care unit on successful resuscitation after OHCA were retrospectively identified and evaluated. Read More

    Anti-inflammatory effect of dexmedetomidine combined with hypothermia on acute respiratory distress syndrome in rats.
    J Surg Res 2017 Aug 10;216:179-184. Epub 2017 May 10.
    Department of Intensive Care Unit, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, PR China. Electronic address:
    Background: To investigate the protective effect of combination of dexmedetomidine and hypothermia on lipopolysaccharide (LPS) induced acute respiratory distress syndrome in rats.

    Methods: Fifty male Wistar rats were randomly divided into five groups, with 10 rats in each group. The acute respiratory distress syndrome model was reproduced by LPS injected into the right external jugular vein (L group); only saline was injected into the right external jugular vein for control group (C group). Read More

    Transient Receptor Potential Vanilloid 1 Antagonists Prevent Anesthesia-induced Hypothermia and Decrease Postincisional Opioid Dose Requirements in Rodents.
    Anesthesiology 2017 Aug 14. Epub 2017 Aug 14.
    From the Institute for Translational Medicine (A.G., E. Pakai, A.M.) and Department of Pharmacology and Pharmacotherapy (E. Pinter), Medical School, University of Pecs, Pecs, Hungary; Departments of Anesthesiology (M.I., K.G., F.P., A.M.P.), Pharmacology (M.I., K.G., R.K., F.P., A.M.P.), and Neuroscience (R.K.), University of Arizona, Tucson, Arizona; Systemic Inflammation Laboratory (FeverLab), Trauma Research, St. Joseph's Hospital and Medical Center, Phoenix, Arizona (A.A.R.).
    Background: Intraoperative hypothermia and postoperative pain control are two important clinical challenges in anesthesiology. Transient receptor potential vanilloid 1 has been implicated both in thermoregulation and pain. Transient receptor potential vanilloid 1 antagonists were not advanced as analgesics in humans in part due to a side effect of hyperthermia. Read More

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