29,686 results match your criteria Therapeutic Hypothermia


Divergent Response to Cannabinoid Receptor Stimulation in High and Low Stress-Induced Analgesia Mouse Lines Is Associated with Differential G-Protein Activation.

Neuroscience 2019 Feb 19. Epub 2019 Feb 19.

Faculty of Pharmacy with the Laboratory Medicine Division, Department of Pharmacodynamics, Medical University of Warsaw, Centre for Preclinical Research and Technology, Warsaw, Poland; Laboratory of Neurogenomics, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Poland; Department of Internal Medicine, Hypertension and Vascular Diseases, Medical University of Warsaw, Warsaw, Poland.

Bidirectional selection of mice for high (HA) and low (LA) swim stress-induced analgesia (SSIA) is associated with a divergent response to opioids. In the current study, we investigated whether the genetic divergence in opioid system activity between HA and LA mice also affects cannabinoid sensitivity. Additionally, we also investigated whether the endocannabinoid system mediates SSIA in these lines. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.02.015DOI Listing
February 2019

Functional Connectivity in Term Neonates With Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia.

Pediatr Neurol 2019 Jan 9. Epub 2019 Jan 9.

Department of Pediatrics, Larner College of Medicine, University of Vermont, Burlington, Vermont.

Background: We investigated whether therapeutic hypothermia and rewarming impact functional connectivity using electroencephalography (EEG) as a measure in neonates with hypoxic-ischemic encephalopathy. We hypothesized that EEG coherence and voltage correlations would be lower and phase lag greater in infants with hypoxic-ischemic encephalopathy than control subjects and that functional connectivity would evolve during therapeutic hypothermia with the greatest improvement occurring during rewarming.

Methods: This study was a retrospective study of 14 term neonates (greater than 37 weeks) with moderate hypoxic-ischemic encephalopathy who underwent therapeutic hypothermia and rewarming. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2019.01.006DOI Listing
January 2019

Response to antiseizure medications in neonates with acute symptomatic seizures.

Epilepsia 2019 Feb 20. Epub 2019 Feb 20.

Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.

In a prospective cohort of 534 neonates with acute symptomatic seizures, 66% had incomplete response to the initial loading dose of antiseizure medication (ASM). Treatment response did not differ by gestational age, sex, medication, or dose. The risk of incomplete response was highest for seizures due to intracranial hemorrhage and lowest for hypoxic-ischemic encephalopathy, although the difference was not significant after adjusting for high seizure burden and therapeutic hypothermia treatment. Read More

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http://dx.doi.org/10.1111/epi.14671DOI Listing
February 2019

Impact of Palliative Care on Resource Utilization and Quality in the Care of Patients Undergoing Therapeutic Hypothermia.

Ther Hypothermia Temp Manag 2019 Feb 21. Epub 2019 Feb 21.

1 Lehigh Valley Health Network, OACIS/Palliative Medicine, Allentown, Pennsylvania.

Few studies have been done assessing the impact of palliative care on patients suffering cardiac arrest and requiring therapeutic hypothermia (TH). We conducted a retrospective cohort study to compare resource utilization and quality indicators among patients undergoing TH with and without palliative care consultation. Data were collected, over a two-year period, from the institutional international cardiac arrest registry database and electronic medical record review. Read More

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http://dx.doi.org/10.1089/ther.2018.0050DOI Listing
February 2019

Impending rupture of aortic aneurysm eroding skin and sternum: a rare condition.

Asian Cardiovasc Thorac Ann 2019 Feb 19:218492319833280. Epub 2019 Feb 19.

Department of Cardiothoracic Surgery, Central Chest Institute of Thailand, Nonthaburi, Thailand.

A rare presentation of ascending aortic aneurysm eroding into the anterior chest wall and skin is described. Only a few reports of this lethal condition associated with luetic disease have been published previously. A 72-year-old man with a history of blunt chest injury subsequently developed a saccular aneurysm of the ascending aorta protruding out of the anterior chest wall. Read More

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http://dx.doi.org/10.1177/0218492319833280DOI Listing
February 2019

Assessment of serum biomarkers and coagulation/fibrinolysis markers for prediction of neurological outcomes of out of cardiac arrest patients treated with therapeutic hypothermia.

Clin Exp Emerg Med 2019 Feb 20. Epub 2019 Feb 20.

Department of Emergency Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.

Objective: Despite increased survival in patients with cardiac arrest, it remains difficult to determine patient prognosis at the early stage. This study evaluated the prognosis of cardiac arrest patients using brain injury, inflammation, cardiovascular ischemic events, and coagulation/fibrinolysis markers collected 24, 48, and 72 hours after return of spontaneous circulation (ROSC).

Methods: From January 2011 to December 2016, we retrospectively observed patients who underwent therapeutic hypothermia. Read More

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http://dx.doi.org/10.15441/ceem.17.273DOI Listing
February 2019

Variability in survival and post-cardiac arrest care following successful resuscitation from out-of-hospital cardiac arrest.

Resuscitation 2019 Feb 13. Epub 2019 Feb 13.

Center for Resuscitation Science and Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

Aim Of The Study: Regionalization of care for out-of-hospital cardiac arrests (OHCA) may improve patient outcomes. We evaluated inter-hospital variations in post-arrest care provision and the relation between hospital case volume and survival in Pennsylvania.

Methods: This retrospective study (2013-2017) used data from adult OHCA cases in Pennsylvania from the Cardiac Arrest Registry to Enhance Survival. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.02.004DOI Listing
February 2019

Repeated cold exposures protect a mouse model of Alzheimer's disease against cold-induced tau phosphorylation.

Mol Metab 2019 Jan 26. Epub 2019 Jan 26.

Faculty of Pharmacy, Université Laval, Quebec City, Qc, Canada; Neurosciences Axis, CHU de Québec-Université Laval Research Center, Quebec City, Qc, Canada. Electronic address:

Objective: Old age is associated with a rise in the incidence of Alzheimer's disease (AD) but also with thermoregulatory deficits. Indicative of a link between the two, hypothermia induces tau hyperphosphorylation. The 3xTg-AD mouse model not only develops tau and amyloid pathologies in the brain but also metabolic and thermoregulatory deficits. Read More

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http://dx.doi.org/10.1016/j.molmet.2019.01.008DOI Listing
January 2019
1 Read

Impact of right ventricular dysfunction on mortality in adults with cardiac arrest undergoing coronary angiogram.

Resuscitation 2019 Feb 12. Epub 2019 Feb 12.

Division of Cardiovascular Medicine, Department of Medicine, State University of New York at Stony Brook, Stony Brook, NY, USA.

Objective We sought to identify the impact of echocardiographic right ventricular (RV) systolic dysfunction on mortality in adults with cardiac arrest (CA). Methods The study population included 147 adults hospitalized with CA who underwent both echocardiogram and coronary angiogram at an academic tertiary medical center. The primary outcome of interest was all-cause in-hospital mortality. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.02.003DOI Listing
February 2019
1 Read

Donor organ intervention before kidney transplantation: Head-to-head comparison of therapeutic hypothermia, machine perfusion, and donor dopamine pretreatment. What is the evidence?

Am J Transplant 2018 Jul 31. Epub 2018 Jul 31.

Department of Immunology, University of Heidelberg, Germany.

Therapeutic hypothermia, hypothermic pulsatile machine perfusion (MP), and renal-dose dopamine administered to stable brain-dead donors have shown efficacy to reduce the dialysis requirement after kidney transplantation. In a head-to-head comparison of the three major randomized controlled trials in this field, we estimated the number-needed-to-treat for each method, evaluated costs and inquired into special features regarding long-term outcomes. The MP and hypothermia trials used any dialysis requirement during the first post-operative week, while the dopamine trial assessed >1 dialysis session as primary endpoint. Read More

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http://dx.doi.org/10.1111/ajt.15317DOI Listing
July 2018
1 Read

Cold at the Core: Osborn Waves in Neurosarcoidosis-Induced Central Hypothermia.

Case Rep Cardiol 2019 15;2019:5845839. Epub 2019 Jan 15.

Department of Medicine, Division of Advanced Heart Failure and Transplant Cardiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

Osborn waves, or J waves, initially described by John Osborn in 1953 in hypothermic dog experiments, are highly sensitive and specific for hypothermia. Initially thought to be secondary to a hypothermia-induced "injury current," they have more recently been attributed to a voltage differential between epicardial and endocardial potassium (I) currents. While the exact conditions required to induce such waves have been debated, numerous clinical scenarios of environmental and iatrogenic hypothermia have been described. Read More

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http://dx.doi.org/10.1155/2019/5845839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350583PMC
January 2019
4 Reads

Continuous-flow cryocompression therapy penetrates to bone level in hip fracture patients in a numerical simulation.

J Orthop Surg Res 2019 Feb 14;14(1):49. Epub 2019 Feb 14.

Department of Orthopedics, Spaarne Gasthuis, Spaarnepoort 1, 2134 TM, Hoofddorp, The Netherlands.

Background: The aim of this study was to define deep tissue temperature during cryotherapy in postoperative hip fracture patients, by using measured skin temperature as input parameter for a simple numerical model. Second, an association was investigated between pain and tissue temperature distribution, to assess cryotherapy-induced analgesia of soft tissue-derived pain.

Methods: Data from 35 participants in an ongoing trial was used. Read More

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http://dx.doi.org/10.1186/s13018-019-1081-5DOI Listing
February 2019
1 Read

Pharmacokinetics of morphine in encephalopathic neonates treated with therapeutic hypothermia.

PLoS One 2019 14;14(2):e0211910. Epub 2019 Feb 14.

Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht, the Netherlands.

Objective: Morphine is a commonly used drug in encephalopathic neonates treated with therapeutic hypothermia after perinatal asphyxia. Pharmacokinetics and optimal dosing of morphine in this population are largely unknown. The objective of this study was to describe pharmacokinetics of morphine and its metabolites morphine-3-glucuronide and morphine-6-glucuronide in encephalopathic neonates treated with therapeutic hypothermia and to develop pharmacokinetics based dosing guidelines for this population. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211910PLOS
February 2019
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Inducing therapeutic hypothermia via selective brain cooling: a finite element modeling analysis.

Med Biol Eng Comput 2019 Feb 12. Epub 2019 Feb 12.

National Center for International Research on Green Optoelectronics, South China Normal University, Waihuan West Road 378, Guangzhou, 510006, People's Republic of China.

Therapeutic hypothermia is a treatment method to reduce brain injuries after stroke, especially for cerebral ischemia. This study investigates in the temperature distribution of the head within selective brain cooling (SBC). Anatomically accurate geometries based on CT images of head and neck regions are used to develop the 3D geometry and physical model for the finite element modeling. Read More

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http://dx.doi.org/10.1007/s11517-019-01962-7DOI Listing
February 2019
1 Read

Evaluating anti-epileptic drugs in the era of therapeutic hypothermia.

Pediatr Res 2019 Jan 30. Epub 2019 Jan 30.

The Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1038/s41390-019-0319-6DOI Listing
January 2019
1 Read

Anthropometric measures as biomarkers of neurodevelopmental outcomes of newborns with moderate to severe hypoxic ischemic encephalopathy.

J Neonatal Perinatal Med 2019 Feb 4. Epub 2019 Feb 4.

Division of Neonatal-Perinatal Medicine, Wayne State University, Children's Hospital of Michigan and Hutzel Women's Hospital, Detroit, MI, USA.

Background: Perinatal asphyxia is a prominent cause of neonatal mortality in the developing world. Growth in head circumference is associated with improved neurodevelopment. Previous studies found a positive correlation between additional dietary supplementation and growth in head circumference among newborns with perinatal brain injury. Read More

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http://dx.doi.org/10.3233/NPM-17151DOI Listing
February 2019
1 Read

Can Therapeutic Hypothermia Diminish the Impact of Traumatic Brain Injury in ?

J Exp Neurosci 2019 21;13:1179069518824852. Epub 2019 Jan 21.

Jefferson Underclassman Multidisciplinary Laboratory (JUMP Lab), Thomas Jefferson High School for Science and Technology, Alexandria, VA, USA.

Background/main Objectives: No effective strategy exists to treat the well-recognized, devastating impact of traumatic brain injury (TBI) and chronic traumatic encephalopathy (CTE), which is the brain degeneration likely caused by repeated head trauma. The goals of this project were (1) to study the effects of single and recurrent TBI (rTBI) on (a) life span, (b) response to sedatives, and (c) behavioral responses to light and gravity and (2) to determine whether therapeutic hypothermia can mitigate the deleterious effects of TBI.

Methods: Five experimental groups were created: (1) control, (2) single TBI or concussion; (3) concussion + hypothermia, (4) rTBI, and (5) rTBI + hypothermia. Read More

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http://dx.doi.org/10.1177/1179069518824852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343440PMC
January 2019
1 Read

Should therapeutic hypothermia be offered to babies with mild neonatal encephalopathy in the first 6 h after birth?

Pediatr Res 2019 Jan 16. Epub 2019 Jan 16.

Department of Physiology, School of Medical Sciences, University of Auckland, Auckland, New Zealand.

Infants with moderate to severe neonatal encephalopathy (NE) benefit significantly from therapeutic hypothermia, with reduced risk of death or disability. However, the need for therapeutic hypothermia for infants with milder NE remains unclear. It has been suggested that these infants should not be offered therapeutic hypothermia as they may not be at risk for adverse neurodevelopmental outcome and that the balance of risk against potential benefit is unknown. Read More

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http://www.nature.com/articles/s41390-019-0291-1
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http://dx.doi.org/10.1038/s41390-019-0291-1DOI Listing
January 2019
5 Reads

Therapeutic hypothermia after traumatic brain injury: Wrong hypotheses may lead to specious interpretations.

Anaesth Crit Care Pain Med 2019 Feb 5. Epub 2019 Feb 5.

Grenoble Alps trauma centre, department of anaesthesiology and intensive care medicine, Grenoble university hospital, 38000, Grenoble, France.

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http://dx.doi.org/10.1016/j.accpm.2019.01.008DOI Listing
February 2019
2 Reads

Clinical Q & A: Translating Therapeutic Temperature Management from Theory to Practice.

Ther Hypothermia Temp Manag 2019 Feb 6. Epub 2019 Feb 6.

1 Mission Neuroscience Institute (NSI), Mission Hospital, Mission Viejo, California.

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http://dx.doi.org/10.1089/ther.2019.29056.mkbDOI Listing
February 2019
1 Read

Engineering Human Stasis for Long-Duration Spaceflight.

Physiology (Bethesda) 2019 Mar;34(2):101-111

Department of Cell and Developmental Biology, University of Colorado School of Medicine , Aurora, Colorado.

Suspended animation for deep-space travelers is moving out of the realm of science fiction. Two approaches are considered: the first elaborates the current medical practice of therapeutic hypothermia; the second invokes the cascade of metabolic processes naturally employed by hibernators. We explore the basis and evidence behind each approach and argue that mimicry of natural hibernation will be critical to overcome the innate limitations of human physiology for long-duration space travel. Read More

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http://dx.doi.org/10.1152/physiol.00046.2018DOI Listing
March 2019
1 Read

Maternal holding during therapeutic hypothermia for infants with neonatal encephalopathy is feasible.

Acta Paediatr 2019 Feb 5. Epub 2019 Feb 5.

Maine Medical Center, Portland, Maine.

Aim: Concerns for infant destabilization often prohibit parental holding of infants during therapeutic hypothermia (TH). We assessed the feasibility of maternal holding during TH, as the inability to hold can impede bonding.

Methods: Vital signs were assessed in stable infants before, at two-minute intervals during and 30 minutes after a single 30-minute holding session. Read More

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http://dx.doi.org/10.1111/apa.14743DOI Listing
February 2019
1 Read

Monitoring Gas Exchange During Hypothermia for Hypoxic-Ischemic Encephalopathy.

Pediatr Crit Care Med 2019 Feb;20(2):166-171

Department of Pediatrics, University of California at Davis, Sacramento, CA.

Objectives: Therapeutic hypothermia is standard of care in management of moderate/severe hypoxic-ischemic encephalopathy. Persistent pulmonary hypertension of the newborn is associated with hypoxic-ischemic encephalopathy and is exacerbated by hypoxemia and hypercarbia. Gas exchange is assessed by arterial blood gas analysis (with/without correction for body temperature), pulse oximetry, and end-tidal CO2. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366447PMC
February 2019
2 Reads

The neurointensive nursery: concept, development, and insights gained.

Curr Opin Pediatr 2019 Jan 31. Epub 2019 Jan 31.

Department Pediatrics, UCSF Benioff Children's Hospital.

Purpose Of Review: With the advent of therapeutic hypothermia for treatment of hypoxic ischemic encephalopathy, and improvements in neuroimaging and bedside neuromonitoring, a new era of neonatal brain-focused care has emerged in recent years. We describe the development of the first neurointensive care nursery (NICN) as a model for comanagement of neonates with identified neurologic risk factors by a multidisciplinary team constituted of neurologists, neonatologists, specialized nurses, and others with the goal of optimizing management, preventing secondary injury and maximizing long-term outcomes.

Recent Findings: Optimizing brain metabolic environment and perfusion and preventing secondary brain injury are key to neurocritical care. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000733DOI Listing
January 2019
2 Reads

The role of microRNAs in newborn brain development and hypoxic ischaemic encephalopathy.

Neuropharmacology 2019 Feb 1;149:55-65. Epub 2019 Feb 1.

Center of Neuroscience, Surgery and Trauma, Blizard Institute, Barts and London School of Medicine and Dentistry, Queen Mary University of London, UK. Electronic address:

Neonates can develop hypoxic-ischaemic encephalopathy (HIE) due to lack of blood supply or oxygen, resulting in a major cause of death and disability among term newborns. However, current definitive treatment of therapeutic hypothermia, will only benefit one out of nine babies. Furthermore, the mechanisms of HIE and therapeutic hypothermia are not fully understood. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2018.11.041DOI Listing
February 2019
1 Read

Combined application of hypothermia and medical gases in cerebrovascular diseases.

Med Gas Res 2018 Oct-Dec;8(4):172-175. Epub 2019 Jan 9.

Department of Neurosurgery & Brain and Nerve Research Laboratory, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.

Cerebrovascular diseases have a heavy burden on society and the family. At present, in the treatment of cerebrovascular diseases, the recognized effective treatment method is a thrombolytic therapy after cerebral infarction, but limited to the time window problem, many patients cannot benefit. Other treatments for cerebrovascular disease are still in the exploration stage. Read More

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http://dx.doi.org/10.4103/2045-9912.248269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352567PMC
January 2019
1 Read

[Therapeutic hypothermia reduced brain damage on rats after cardiopulmonary resuscitation by activating III-type PI3K pathway to increase autophagy].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2019 Jan;31(1):55-60

Department of Emergency, Second Affiliated Hospital of Soochow University, Suzhou 215008, Jiangsu, China. Corresponding author: Liu Lijun, Email:

Objective: To investigate the effect of III-type phosphatidylinositide 3 kinase (PI3K) pathway adjusting autophagy on brain damage mechanism after cardiopulmonary resuscitation (CPR) and hypothermia treatment.

Methods: The asphyxia induce cardiac arrest-CPR model was reproduced on healthy male Sprague-Dawley (SD) rats. Sixty rats after restoration of spontaneous circulation (ROSC) were randomly divided into normothermia group, therapeutic hypothermia group and PI3K inhibitor 3-methyl adenine (3-MA) pretreatment group, differentiated by 24 hours and 48 hours after ROSC. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2019.01.012DOI Listing
January 2019
2 Reads

Trauma-Induced Coagulopathy.

Authors:
Sirak Petros

Hamostaseologie 2019 Feb 31;39(1):20-27. Epub 2019 Jan 31.

Medical ICU, University Hospital, Leipzig, Germany.

Trauma-induced coagulopathy (TIC) is a heterogeneous entity that contributes to a significant morbidity and mortality following trauma. The activated protein C system, endotheliopathy and platelet dysfunction have been implicated in the pathogenesis of TIC, although there are still controversies on the exact pathogenesis. TIC can be modified by hypoperfusion, acidosis, hypothermia, haemodilution, underlying disease conditions, pre-injury medications as well as genetic predispositions. Read More

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http://dx.doi.org/10.1055/s-0039-1677853DOI Listing
February 2019
1 Read

Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT receptor ligands.

Eur J Med Chem 2019 Jan 22;166:144-158. Epub 2019 Jan 22.

Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1, Banacha Street, 02-097 Warsaw, Poland.

The study enabled obtaining a number of new derivatives of 4-aryl-pyrido[1,2-c]pyrimidine 9.1-9.27 having conformationally restricted tryptamine moiety. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02235234193004
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http://dx.doi.org/10.1016/j.ejmech.2019.01.031DOI Listing
January 2019
3 Reads

Update on the management of acute liver failure.

Curr Opin Crit Care 2019 Jan 28. Epub 2019 Jan 28.

Liver Intensive Therapy Unit, Institute of Liver Studies, King's College Hospital, Denmark Hill, London, UK.

Purpose Of Review: This review describes the current intensive care management of acute liver failure (ALF) and the latest evidence for emerging therapies.

Recent Findings: Mortality from ALF continues to improve and in some cases, medical therapy can negate the need for liver transplantation because of protocolized management in specialist centres. Liver transplantation remains the cornerstone of management for poor prognosis ALF. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000583DOI Listing
January 2019
2 Reads

Nimbolide protects against endotoxin-induced acute respiratory distress syndrome by inhibiting TNF-α mediated NF-κB and HDAC-3 nuclear translocation.

Cell Death Dis 2019 Jan 28;10(2):81. Epub 2019 Jan 28.

Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana, 500037, India.

Acute respiratory distress syndrome (ARDS) is characterized by an excessive acute inflammatory response in lung parenchyma, which ultimately leads to refractory hypoxemia. One of the earliest abnormalities seen in lung injury is the elevated levels of inflammatory cytokines, among them, the soluble tumor necrosis factor (TNF-α) has a key role, which exerts cytotoxicity in epithelial and endothelial cells thus exacerbates edema. The bacterial lipopolysaccharide (LPS) was used both in vitro (RAW 264. Read More

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http://www.nature.com/articles/s41419-018-1247-9
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http://dx.doi.org/10.1038/s41419-018-1247-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349848PMC
January 2019
4 Reads

Lipidized Prolactin-Releasing Peptide Agonist Attenuates Hypothermia-Induced Tau Hyperphosphorylation in Neurons.

J Alzheimers Dis 2019 Jan 21. Epub 2019 Jan 21.

Institute of Organic Chemistry and Biochemistry, AS CR, Prague, Czech Republic.

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by the accumulation of extracellular amyloid plaques and intraneuronal neurofibrillary tangles. These tangles mainly consist of hyperphosphorylated tau protein. As it induces tau hyperphosphorylation in vitro and in vivo, hypothermia is a useful tool for screening potential neuroprotective compounds that ameliorate tau pathology. Read More

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http://dx.doi.org/10.3233/JAD-180837DOI Listing
January 2019
2 Reads

TRPV1 Inhibits the Ventilatory Response to Hypoxia in Adult Rats, but Not the CO₂-Drive to Breathe.

Pharmaceuticals (Basel) 2019 Jan 24;12(1). Epub 2019 Jan 24.

Department of Animal Morphology and Physiology, Faculty of Agricultural and Veterinarian Sciences, UNESP at Jaboticabal, Rod. Prof. Paulo Donato Castellane s/n, Jaboticabal SP 14870-000, Brazil.

Receptors of the transient receptor potential (TRP) channels superfamily are expressed in many tissues and have different physiological functions. However, there are few studies investigating the role of these channels in cardiorespiratory control in mammals. We assessed the role of central and peripheral TRPV1 receptors in the cardiorespiratory responses to hypoxia (10% O₂) and hypercapnia (7% CO₂) by measuring pulmonary ventilation ( V ˙ E ), heart rate (HR), mean arterial pressure (MAP) and body temperature (Tb) of male Wistar rats before and after intraperitoneal (AMG9810 [2. Read More

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http://dx.doi.org/10.3390/ph12010019DOI Listing
January 2019
2 Reads

Tumor resection ameliorates tumor-induced suppression of neuroinflammatory and behavioral responses to an immune challenge in a cancer survivor model.

Sci Rep 2019 Jan 24;9(1):752. Epub 2019 Jan 24.

Institute for Behavioral Medicine Research, Ohio State University Wexner Medical Center, Columbus, OH, USA.

Breast cancer survivors display altered inflammatory responses to immune challenges relative to cancer-naive controls likely due to previous cancer treatments, stress associated with cancer, and/or tumor physiology. Proper inflammatory responses are necessary for adaptive sickness behaviors (e.g. Read More

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http://dx.doi.org/10.1038/s41598-018-37334-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345941PMC
January 2019

The effects of ATP on the contractions of rat and mouse fast skeletal muscle.

Muscle Nerve 2019 Jan 24. Epub 2019 Jan 24.

Department of Medical and Biological Physics, Kazan State Medical University, Kazan, Russia.

Introduction: The aim of this study was to compare the effects of adenosine-5'-triphosphate (ATP) and adenosine on the contractility of rodent extensor digitorum longus (EDL) muscle at normal and low temperatures.

Methods: Contractions of rat and mouse isolated EDL were induced by either electrical stimulation (ES) or exogenous carbachol and recorded in the presence of ATP or adenosine (both at 100 μM).

Results: ATP at all temperatures caused a decrease of the contractions induced by carbachol in rat and mouse EDL and ES-induced contractions in rat EDL, while it potentiated the ES-induced contractions of mouse EDL. Read More

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http://dx.doi.org/10.1002/mus.26423DOI Listing
January 2019
2 Reads

Therapeutic Hypothermia After Perinatal Asphyxia in Infants With Severe, Ductal-Dependent Congenital Heart Disease.

Pediatr Crit Care Med 2019 Jan 22. Epub 2019 Jan 22.

Department of Neonatology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Objectives: Patients with severe congenital heart disease and cardiac anomalies such as restrictive foramen ovale, intact atrial septum, or narrowing of ductus arteriosus are at risk for perinatal asphyxia, leading to hypoxic-ischemic encephalopathy. We hypothesize that therapeutic hypothermia can be applied to these patients and seek to investigate feasibility and safety of this method.

Design: A retrospective observational study. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001878DOI Listing
January 2019
1 Read

Lack of Variability in Cerebral Oximetry Tendency in Infants with Severe Hypoxic-Ischemic Encephalopathy Under Hypothermia.

Ther Hypothermia Temp Manag 2019 Jan 24. Epub 2019 Jan 24.

2 Fundación NeNe, Madrid, Spain.

Cerebral oximetry using near-infrared spectroscopy (NIRS) provides continuous, noninvasive assessment of the degree of hemoglobin saturation of the brain tissue. Previous studies suggest that high values of regional cerebral tissue oxygen saturation (rScO) during the first days in neonates with significant hypoxic-ischemic encephalopathy (HIE) are correlated with an adverse neurological outcome. However, the results are not consistent among the studies. Read More

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http://dx.doi.org/10.1089/ther.2018.0041DOI Listing
January 2019
2 Reads

Phenytoin-induced hypothermia.

BMJ Case Rep 2019 Jan 22;12(1). Epub 2019 Jan 22.

Department of Rheumatology, Glasgow Royal Infirmary, Glasgow, UK.

A 60-year-old man with cerebral palsy and epilepsy was admitted with acute lethargy and deterioration in coordination. He was noted to be hypothermic at 35°C on admission. Routine work-up revealed toxic levels of phenytoin. Read More

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http://dx.doi.org/10.1136/bcr-2018-227443DOI Listing
January 2019
1 Read

Hypothermia alleviated LPS-induced acute lung injury in Rat models through TLR2/MyD88 pathway.

Exp Lung Res 2019 Jan 19:1-8. Epub 2019 Jan 19.

a Department of Critical Care Medicine , the First Affiliated Hospital of Guangxi Medical University , Nanning , Guangxi Zhuang Autonomous Region, China.

Acute lung injury (ALI) is a common clinical syndrome in ICU departments with high mortality. The pathology of ALI is still not clear and there is no specific and efficient treatment against ALI. In this study, we established ALI rat model through lipopolysaccharide administration. Read More

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http://dx.doi.org/10.1080/01902148.2018.1557299DOI Listing
January 2019
6 Reads

A pharmacological composition for induction of a reversible torpor-like state and hypothermia in rats.

Life Sci 2019 Feb 16;219:190-198. Epub 2019 Jan 16.

Russian Foundation for Advanced Research, Russia.

Aims: To initiate a state of artificial torpor we suggested a pharmacological multi-targeting strategy for simulation of the physiological pattern of natural hibernation including a significant reduction in heart rate, respiratory rate, body temperature and oxygen consumption as well as a decline in brain activity known as torpor.

Materials And Methods: We have developed a composition which initiates a pharmacologically induced torpor-like state (PITS-composition), made up of eight therapeutic agents, inert gas xenon and lipid emulsion served as a drug vehicle.

Key Findings: After a single intravenous injection to rats, PITS-composition causes a rapid decline in heart rate followed by a steady decrease in body temperature from about 38. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.023DOI Listing
February 2019
6 Reads

Hypothermia for newborns with hypoxic-ischemic encephalopathy.

Paediatr Child Health 2018 Jul 12;23(4):285-291. Epub 2018 Jun 12.

Canadian Paediatric Society, Fetus and Newborn Committee, Ottawa, Ontario.

Therapeutic hypothermia is a standard of care for infants ≥36 weeks gestational age (GA) with moderate-to-severe hypoxic-ischemic encephalopathy. Because some studies included infants born at 35 weeks GA, hypothermia should be considered if they meet other criteria. Cooling for infants <35 weeks GA is not recommended. Read More

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http://dx.doi.org/10.1093/pch/pxy028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007306PMC
July 2018
7 Reads

Food protein-induced enterocolitis syndrome: guidelines summary and practice recommendations.

Med J Aust 2019 Feb 18;210(2):94-99. Epub 2019 Jan 18.

Children's Hospital at Westmead, Sydney, NSW.

Food protein-induced enterocolitis syndrome (FPIES) is a poorly understood non-IgE gastrointestinal-mediated food allergy that predominantly affects infants and young children. Cells of the innate immune system appear to be activated during an FPIES reaction. Acute FPIES typically presents between one and 4 hours after ingestion of the trigger food, with the principal symptom being profuse vomiting, and is often accompanied by pallor and lethargy. Read More

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http://dx.doi.org/10.5694/mja2.12071DOI Listing
February 2019
5 Reads

Association between lymphocyte count and neurological outcomes in post-cardiac arrest patients treated with mild therapeutic hypothermia.

Acute Med Surg 2019 Jan 4;6(1):30-39. Epub 2018 Oct 4.

Department of Critical and Intensive Care Medicine Shiga University of Medical Science Otsu Japan.

Aim: To examine lymphocyte counts as a predictive prognostic marker in patients with coma after cardiac arrest.

Methods: We retrospectively evaluated patients with coma after cardiac arrest admitted to the intensive care unit of Shiga University of Medical Science (Otsu, Japan). Lymphocyte counts were measured for 6 days from admission. Read More

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http://dx.doi.org/10.1002/ams2.374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328908PMC
January 2019
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The relationship between neonatal encephalopathy and maternal postpartum depression.

J Matern Fetal Neonatal Med 2019 Feb 3:1-5. Epub 2019 Feb 3.

a Department of Pediatrics , University of Nebraska Medical Center , Omaha , NE , USA.

Purpose: Neonatal hypoxic-ischemic encephalopathy (HIE) is a type of brain injury resulting from insufficient oxygen and blood supply. The standard treatment for HIE is therapeutic hypothermia (TH), which involves a 72-h period of hypothermia, during which time the infant is isolated from his/her parents. The primary objective of this study was to assess the effects of the diagnosis of neonatal encephalopathy and subsequent separation on rates of maternal postpartum depression (PPD) as compared to other hospitalized infants. Read More

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http://dx.doi.org/10.1080/14767058.2019.1571574DOI Listing
February 2019
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Effectiveness and safety of early enteral nutrition for patients who received targeted temperature management after out-of-hospital cardiac arrest.

Resuscitation 2019 Jan 14;135:191-196. Epub 2019 Jan 14.

Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Yoshidakonoecho, Sakyo-ku, Kyoto-city, Japan; Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto, Japan. Electronic address:

Aim: Early enteral nutrition (EN) is recommended for critically ill patients; however, few reports have examined early EN for patients who received targeted temperature management (TTM) after out-of-hospital cardiac arrest (OHCA). We investigated the effectiveness and safety of early EN for patients who received TTM after OHCA.

Methods: We used a nationwide Japanese administrative database to identify OHCA patients who received TTM from April 2008 to March 2017. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.01.007DOI Listing
January 2019
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Temporal Trends in the Use of Therapeutic Hypothermia for Out-of-Hospital Cardiac Arrest.

JAMA Netw Open 2018 Nov 2;1(7):e184511. Epub 2018 Nov 2.

University of Iowa Carver College of Medicine, Iowa City.

Importance: Despite evidence that therapeutic hypothermia improves patient outcomes for out-of-hospital cardiac arrest, use of this therapy remains low.

Objective: To determine whether the use of therapeutic hypothermia and patient outcomes have changed after publication of the Targeted Temperature Management trial on December 5, 2013, which supported more lenient temperature management for out-of-hospital cardiac arrest.

Design, Setting, And Participants: A retrospective cohort was conducted between January 1, 2013, and December 31, 2016, of 45 935 US patients in the Cardiac Arrest Registry to Enhance Survival who experienced out-of-hospital cardiac arrest and survived to hospital admission. Read More

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2018.4511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324404PMC
November 2018
17 Reads

Pattern of Brain Injury Predicts Long-Term Epilepsy Following Neonatal Encephalopathy.

J Child Neurol 2019 Jan 15:883073818822361. Epub 2019 Jan 15.

1 Department of Pediatrics, Neurology, University of British Columbia and BC Children's Hospital, Vancouver, British Columbia, Canada.

Objective:: To determine if patterns of hypoxic-ischemic brain injury on magnetic resonance imaging (MRI) in term newborns predict subsequent childhood epilepsy. Methods: This retrospective cohort study includes term newborns with encephalopathy (n = 181) born between 2004-2012 and admitted to British Columbia Children's Hospital. MRI was performed between 3 and 5 days of age. Read More

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http://dx.doi.org/10.1177/0883073818822361DOI Listing
January 2019
2 Reads
1.666 Impact Factor

Bystander use of automated external defibrillators in the Spanish autonomous community of the Principality of Asturias in 2012-2014.

Emergencias 2018 Dic;30(6):415-418

Unidad de Investigación en Emergencia y Desastre. Universidad de Oviedo, España.

En: On-site bystander use of automated external defibrillators (AEDs) was analized in Asturias, Spain, between January 2012 and December 2014. Hospital management and neurologic state on discharge were also studied. Our retrospective observational population-based design had 3 phases comrpising: 1) a telephone survey of facilities with onsite public-access AEDsc, 2) analysis of relevant case records held by the Asturian emergency medical service, and 3) analysis of relevant hospital case records. Read More

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January 2019
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The depth of anaesthesia associated with the administration of isoflurane 2.5% during cardiopulmonary bypass.

Perfusion 2019 Jan 12:267659118822946. Epub 2019 Jan 12.

5 Mass Spectrometry Core, Edinburgh Clinical Research Facility, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK.

Background:: Administering isoflurane 2.5% into the oxygenator during cardiopulmonary bypass results in no patient movement. However, doing so may result in an excessive depth of anaesthesia particularly, when hypothermia is induced. Read More

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http://dx.doi.org/10.1177/0267659118822946DOI Listing
January 2019
3 Reads

Therapeutic Hypothermia in Neonatal Hypoxic-Ischemic Encephalopathy.

Curr Neurol Neurosci Rep 2019 Jan 14;19(2). Epub 2019 Jan 14.

Department of Physiology, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Private Bag, Auckland, 92019, New Zealand.

Purpose Of Review: Therapeutic hypothermia reduces death or disability in term and near-term infants with moderate-severe hypoxic-ischemic encephalopathy. Nevertheless, many infants still survive with disability, despite hypothermia, supporting further research in to ways to further improve neurologic outcomes.

Recent Findings: Recent clinical and experimental studies have refined our understanding of the key parameters for hypothermic neuroprotection, including timing of initiation, depth, and duration of hypothermia, and subsequent rewarming rate. Read More

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http://dx.doi.org/10.1007/s11910-019-0916-0DOI Listing
January 2019
1 Read