31,605 results match your criteria Therapeutic Hypothermia


Measuring the impact of cardiotocograph decision support software on neonatal outcomes: A propensity score-matched observational study.

Aust N Z J Obstet Gynaecol 2021 May 13. Epub 2021 May 13.

Mater Mothers' Hospital, South Brisbane, Queensland, Australia.

Background: This study follows the 2017 UK INFANT Collaborative Group RCT, which compared neonatal outcomes with and without the use of the INFANT cardiotocograph decision support system for over 46 000 patients in labour. The original trial failed to demonstrate a significant improvement to neonatal outcomes; however, the study design was subject to methodological critique.

Aims: This Australian retrospective cohort study aimed to report perinatal outcomes before and after the introduction of INFANT decision support software for cardiotocograph use in labour. Read More

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Targeted temperature management at 33 degrees Celsius in patients with high-grade aneurysmal subarachnoid hemorrhage: a protocol for a multicenter randomized controlled study.

Ann Transl Med 2021 Apr;9(7):581

Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

Background: Studies on the use of therapeutic hypothermia (TH) to improve the outcome of high-grade aneurysmal subarachnoid hemorrhage (aSAH), show promising, though conflicting results because of the lack of high-quality trials. The aim of this study is to evaluate the safety and efficacy of TH (maintaining bladder temperature at 33 °C for ≥72 h) to treat patients with high-grade aSAH (Hunt-Hess grade IV-V).

Methods: A multicenter, randomized, controlled clinical trial will be conducted for October 2020 to September 2024 involving 10 clinics. Read More

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PGD /CRTH2 signaling promotes acquired immunity against bee venom by enhancing IgE production.

FASEB J 2021 Jun;35(6):e21616

Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.

IgE-dependent/independent activation of mast cell (MC) has been assumed to play a host defensive role against venom injection in skin. However, its detailed mechanisms remain unknown. We aimed to investigate the contribution of MC-derived prostaglandin D (PGD )-mediated signaling in host defense against bee venom (BV). Read More

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Icariin enhance mild hypothermia-induced neuroprotection via inhibiting the activation of NF-κB in experimental ischemic stroke.

Metab Brain Dis 2021 May 12. Epub 2021 May 12.

Department of Critical Care Medicine, Hainan Medical University, No.48, Baishuitang Road, Haikou, 460106, Hainan, China.

Therapeutic hypothermia (TH) is a promising neuroprotective agent for treating stroke. However, its clinical application was limited by the impractical duration. Icariin (ICA) were reported to have therapeutic effect on cerebral ischemia. Read More

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Brain and Myocardial Mitochondria Follow Different Patterns of Dysfunction After Cardiac Arrest.

Shock 2021 May 11. Epub 2021 May 11.

Univ Paris Est Créteil, INSERM, IMRB, F-94010 Créteil, France Ecole nationale vétérinaire d'Alfort, IMRB, F-94700 Maisons-Alfort, France.

Abstract: Mitochondria is often considered as the common nexus of cardiac and cerebral dysfunction after cardiac arrest. Here, our goal was to determine whether the time course of cardiac and cerebral mitochondrial dysfunction is similar after shockable vs nonshockable cardiac arrest in rabbits. Anesthetized rabbits were submitted to 10 min of no-flow by ventricular fibrillation (VF group) or asphyxia (non-shockable group). Read More

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The effect of mild hypothermia plus rutin on the treatment of spinal cord injury and inflammatory factors by repressing TGF-β/smad pathway.

Acta Cir Bras 2021 7;36(3):e360307. Epub 2021 May 7.

PhD. Department of Spine Surgery - Guizhou Orthopedic Hospital - Guizhou Province, China.

Purpose: To probe the mechanism of mild hypothermia combined with rutin in the treatment of spinal cord injury (SCI).

Methods: Thirty rats were randomized into the following groups: control, sham, model, mild hypothermia (MH), and mild hypothermia plus rutin (MH+Rutin). We used modified Allen's method to injure the spinal cord (T10) in rats, and then treated it with MH or/and rutin immediately. Read More

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Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia in mice.

Nat Commun 2021 May 11;12(1):2648. Epub 2021 May 11.

National Institute of Biological Sciences (NIBS), Beijing, China.

The neural mechanisms of fear-associated thermoregulation remain unclear. Innate fear odor 2-methyl-2-thiazoline (2MT) elicits rapid hypothermia and elevated tail temperature, indicative of vasodilation-induced heat dissipation, in wild-type mice, but not in mice lacking Trpa1-the chemosensor for 2MT. Here we report that Trpa1 mice show diminished 2MT-evoked c-fos expression in the posterior subthalamic nucleus (PSTh), external lateral parabrachial subnucleus (PBel) and nucleus of the solitary tract (NTS). Read More

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Mild hypothermia facilitates mitochondrial transfer from astrocytes to injured neurons during oxygen-glucose deprivation/reoxygenation.

Neurosci Lett 2021 May 7:135940. Epub 2021 May 7.

Department of Anesthesiology, Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China. Electronic address:

Mitochondrial dysfunction is now considered an important sign of neuronal death during cerebral ischemia/reperfusion (I/R) injury. Studies have shown that the transfer of mitochondria from astrocytes to injured neurons contributes to endogenous neuroprotection after stroke. Basic and clinical studies have shown that mild hypothermia exerts a clear protective effect on neurons after cerebral ischemic injury, but the role of mild hypothermia in this endogenous neuroprotective mechanism remains unclear. Read More

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Effects of hypothermia on inflammatory cytokine expression in rat liver following asphyxial cardiac arrest.

Exp Ther Med 2021 Jun 15;21(6):626. Epub 2021 Apr 15.

Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea.

Hypothermic treatment is known to protect against cardiac arrest (CA) and improve survival rate. However, few studies have evaluated the CA-induced liver damage and the effects of hypothermia on this damage. Therefore, the aim of the present study was to determine possible protective effects of hypothermia on the liver after asphyxial CA. Read More

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Transcriptome analysis of mild hypothermia protection against radiationinduced rat lung injury based on RNAseq.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Apr;46(4):345-350

Drug Safety Evaluation Center of China Institute for Radiation Protection; Shanxi Key Laboratory of Drug Toxicology and Drug for Radiation Injury; Key Laboratory on Radiotoxicology and Radiopharmaceutical Preclinical Evaluation, China National Nuclear Corporation, Taiyuan 030006, China.

Objectives: To analyze the differentially expressed genes (DEGs) with radiation-induced rat lung injury, and to reveal the protective mechanism for mild hypothermia in the radiation-induced lung injury in rats at the transcriptome level.

Methods: A total of 10 male SD rats aged 6-8 weeks were randomly divided into 2 groups to establish a rat model of radiation-induced lung injury, and one group was treated with mild hypothermia. RNA was extracted from left lung tissue of each group, and sequenced by BGISEQ-500 platform. Read More

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Systems Biology Model of Cerebral Oxygen Delivery and Metabolism During Therapeutic Hypothermia: Application to the Piglet Model.

Adv Exp Med Biol 2021 ;1269:31-38

Department of Medical Physics and Biomedical Engineering, University College London, London, UK.

Hypoxic ischaemic encephalopathy (HIE) is a significant cause of death and disability. Therapeutic hypothermia (TH) is the only available standard of treatment, but 45-55% of cases still result in death or neurodevelopmental disability following TH. This work has focussed on developing a new brain tissue physiology and biochemistry systems biology model that includes temperature effects, as well as a Bayesian framework for analysis of model parameter estimation. Read More

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Prognostic value of brainstem auditory and visual evoked potentials in cardiac arrest patients with targeted temperature management.

Resuscitation 2021 May 5;164:12-19. Epub 2021 May 5.

Department of Emergency Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Purpose: We analysed the prognostic value of somatosensory, brainstem auditory and visual evoked potentials (SSEPs, BAEPs and VEPs, respectively) for outcome prediction in cardiac arrest patients with targeted temperature management (TTM) and assessed whether BAEP and VEP measurements conferred added value to SSEP measurements.

Methods: Cases with SSEPs and VEPs or BAEPs were reviewed in a TTM registry. We focused on whether the following responses were clearly discernible: N20 for SSEPs, V for BAEPs, and P100 for VEPs. Read More

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Lectin-like oxidized low-density lipoprotein receptor-1 related microglial activation in neonatal hypoxic-ischemic encephalopathy: morphological consideration.

Am J Pathol 2021 May 5. Epub 2021 May 5.

Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira. Electronic address:

Neonatal hypoxic-ischemic encephalopathy (nHIE) is a major neonatal brain injury. Despite therapeutic hypothermia, mortality and sequelae remain severe. The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) was associated with the pathophysiology of nHIE. Read More

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Noninvasive monitoring of evolving urinary metabolic patterns in neonatal encephalopathy.

Pediatr Res 2021 May 5. Epub 2021 May 5.

Neonatal Research Group, Health Research Institute La Fe, Valencia, Spain.

Background: Infants with moderate and severe neonatal encephalopathy (NE) frequently suffer from long-term adverse outcomes. We hypothesize that the urinary metabolome of newborns with NE reflects the evolution of injury patterns observed with magnetic resonance imaging (MRI).

Methods: Eligible patients were newborn infants with perinatal asphyxia evolving to NE and qualifying for therapeutic hypothermia (TH) included in the HYPOTOP trial. Read More

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Author Correction: Molecular and biophysical mechanisms behind the enhancement of lung surfactant function during controlled therapeutic hypothermia.

Sci Rep 2021 May 5;11(1):9990. Epub 2021 May 5.

Department of Biochemistry and Molecular Biology and Research Institute "Hospital 12 de Octubre (imas12), Faculty of Biology, Complutense University, Jose Antonio Novais 12, Madrid, Spain.

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Administration of parenteral nutrition during therapeutic hypothermia: a population level observational study using routinely collected data held in the National Neonatal Research Database.

Arch Dis Child Fetal Neonatal Ed 2021 May 5. Epub 2021 May 5.

Division of Neonatal-Perinatal Medicine, Dalhousie University-Faculty of Medicine, Halifax, Nova Scotia, Canada.

Background: Parenteral nutrition is commonly administered during therapeutic hypothermia. Randomised trials in critically ill children indicate that parenteral nutrition may be harmful.

Objective: To examine the association between parenteral nutrition during therapeutic hypothermia and clinically important outcomes. Read More

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Association of Total Sarnat Score with brain injury and neurodevelopmental outcomes after neonatal encephalopathy.

Arch Dis Child Fetal Neonatal Ed 2021 May 5. Epub 2021 May 5.

Centre for Perinatal Neuroscience, Brain Sciences Department, Imperial College of Science Technology and Medicine, London, UK.

We examined the association of Total Sarnat Score (TSS) with brain injury on neonatal magnetic resonance (MR) and adverse neurodevelopmental outcome (NDO) (death or moderate or severe disability) at 2 years of age in 145 infants undergoing therapeutic hypothermia for neonatal encephalopathy. TSS was associated with basal ganglia/thalamic injury on conventional MR (p=0.03) and thalamic N-acetyl aspartate on MR spectroscopy (R=0. Read More

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High rate of critical coronary stenosis in comatose patients with Non-ST-elevation out-of-hospital cardiac arrest (NSTE-OHCA) undergoing therapeutic hypothermia-Experience from the HAnnover COoling REgistry (HACORE).

PLoS One 2021 4;16(5):e0251178. Epub 2021 May 4.

Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Hannover, Germany.

Background: Myocardial infarction is the most frequent cause for out-of-hospital cardiac arrest (OHCA) in adults. Patients with ST-segment elevations (STE) following return of spontaneous circulation (ROSC) are regularly admitted to the catheterisation laboratory for urgent coronary angiography. Whether patients without obvious STE (NSTE) should receive coronary angiography as part of a standardised diagnostic work-up following OHCA is still debated. Read More

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Extensive subcutaneous fat necrosis complicated by neonatal hypercalcaemia.

Acta Biomed 2021 Apr 30;92(S1):e2021081. Epub 2021 Apr 30.

king abdulaziz university hospital.

subcutaneous fat necrosis is a benign and often self-limiting inflammatory disorder experienced by newborns who were exposed to perinatal stress in the form of asphyxia, hypothermia, cord prolapse, and/or sepsis. lesions are usually benign and self-limiting, with complete resolution anticipated within a few weeks up to 6 months. they can be accompanied by multiple complications. Read More

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Centre-specific differences in short-term outcomes in neonates with hypoxic-ischaemic encephalopathy.

Swiss Med Wkly 2021 Mar 5;151:w20489. Epub 2021 Apr 5.

Clinic of Neonatology, Cantonal Hospital Winterthur, Switzerland.

Aims Of The Study: To investigate and compare the centre-specific short-term outcome indicators seizures, arterial hypotension, infection and mortality during therapeutic hypothermia until discharge from the neonatal/paediatric intensive care unit in term and near-term neonates with hypoxic-ischaemic encephalopathy (HIE) registered in the Swiss National Asphyxia and Cooling Register between 2011 and 2018.

Methods: Retrospective analysis of prospectively collected national register data between 1 January 2011 and 31 December 2018. Pregnancy, maternal, delivery and neonatal characteristics were compared between the centres. Read More

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Effect of Amiodarone and Hypothermia on Arrhythmia Substrates During Resuscitation.

J Am Heart Assoc 2021 May 3:e016676. Epub 2021 May 3.

Department of Emergency Medicine and The Heart and Vascular Research Center MetroHealth Campus Case Western Reserve University Cleveland OH.

Background Amiodarone is administered during resuscitation, but its antiarrhythmic effects during targeted temperature management are unknown. The purpose of this study was to determine the effect of both therapeutic hypothermia and amiodarone on arrhythmia substrates during resuscitation from cardiac arrest. Methods and Results We utilized 2 complementary models: (1) In vitro no-flow global ischemia canine left ventricular transmural wedge preparation. Read More

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Factors affecting outcomes in patients with cardiac arrest who receive target temperature management: The multi-center TIMECARD registry.

J Formos Med Assoc 2021 Apr 29. Epub 2021 Apr 29.

Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Background: Target temperature management (TTM) is a recommended therapy for patients after cardiac arrest (PCA). The TaIwan Network of Targeted Temperature ManagEment for CARDiac Arrest (TIMECARD) registry was established for PCA who receive TTM therapy in Taiwan. We aim to determine the variables that may affect neurologic outcomes in PCA who undergo TTM. Read More

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[Spontaneous periodic hypothermia syndrome: A systematic review of the literature].

Rev Med Interne 2021 Apr 28. Epub 2021 Apr 28.

Service de médecine interne, CHU de Saint-Étienne, 42055 Saint-Étienne cedex, France.

Introduction: Periodic spontaneous hypothermia syndrome (PSHS), also known as hypersudation-hypothermia syndrome, is a rare condition characterised by the occurrence of paroxysmal attacks of spontaneous hypothermia occurring without age limit. Few studies have attempted to synthesise the available data on PSHS. The objective of this study was to summarize the literature on this condition. Read More

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Fast hypothermia induced by extracorporeal circuit cooling alleviates renal and intestinal injury after cardiac arrest in swine.

Am J Emerg Med 2021 Apr 23;47:231-238. Epub 2021 Apr 23.

Hangzhou Emergency Medical Center of Zhejiang Province, Zhejiang, Hangzhou, China. Electronic address:

Background: Continuous renal replacement therapy (CRRT) was currently demonstrated to be an effective way to induce fast hypothermia and had proective effects on cardiac dysfunction and brain damage after cardiac pulmonary resuscitation (CPR). In the present study, we aimed to investigate the influence of extracorporeal circuit cooling using CRRT on renal and intestinal damage after CPR based on a porcine model.

Methods: 32 pigs were subjected to ventricular fibrillation for 8 min, followed by CPR for 5 min before defibrillation. Read More

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Anticonvulsive profile of two GABA receptor antagonists on acute seizure mice models.

Epilepsy Res 2021 Apr 20;174:106644. Epub 2021 Apr 20.

Inserm, Biochemistry and Molecular Biology Laboratory, HMNO, CBP, CHRU Lille & EA 7364 - RADEME, North France University Lille, 2, Bld Prof Jules Leclercq, 59037, Lille, France. Electronic address:

Introduction: DL-3-hydroxy-3-phenylpentanamide (HEPP) and DL-3-hydroxy-3-(4'chlorophenyl)-pentanamide (Cl-HEPP) are phenyl-alcohol-amides that are metabotropic GABAB receptor (MGBR) antagonists and protective against absence seizures. This study aims to further characterize the anticonvulsant profile of these drugs.

Methods: HEPP and Cl-HEPP were evaluated in various standardized acute seizure and toxic tests in female Swiss-OF1 mice. Read More

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Brain MRI after therapeutic hypothermia in asphyxiated newborns: Predictive value at one year of imaging features.

Eur J Radiol 2021 Apr 15;139:109724. Epub 2021 Apr 15.

Service d'imagerie anténatale, de l'enfant et de la femme, Hôpital Pellegrin, place Amélie Raba-Léon, F-33076, Bordeaux, France; CRMSB, UMR5536 CNRS/Univ. Bordeaux, F-33076, Bordeaux, France. Electronic address:

Purpose: To compare early brain MRI using a composite imaging score and outcome at one year in asphyxiated newborns treated by hypothermia.

Methods: This retrospective study included for two years consecutive asphyxiated term newborns treated by hypothermia for hypoxic-ischemic encephalopathy, and who had brain MRI before day 8. Therapeutic hypothermia was initiated within the first 6 h of life and continued for 72 h. Read More

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