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    Body temperature responses to handling stress in wintering Black-capped Chickadees (Poecile atricapillus L.).
    Physiol Behav 2017 May 18. Epub 2017 May 18.
    Département de biologie, chimie et géographie, Groupe de recherche sur les environnements nordiques BORÉAS, Centre d'Etudes Nordiques, Centre de la Science de la Biodiversité du Québec, Université du Québec à Rimouski, Rimouski, Canada.
    Body temperature variation in response to acute stress is typically characterized by peripheral vasoconstriction and a concomitant increase in core body temperature (stress-induced hyperthermia). It is poorly understood how this response differs between species and within individuals of the same species, and how it is affected by the environment. We therefore investigated stress-induced body temperature changes in a non-model species, the Black-capped Chickadee, in two environmental conditions: outdoors in low ambient temperature (mean: -6. Read More

    Transapical aortic perfusion using a deep hypothermic procedure to prevent dissecting lung injury during re-do thoracoabdominal aortic aneurysm surgery.
    J Cardiothorac Surg 2017 May 19;12(1):32. Epub 2017 May 19.
    Department of Thoracic and Cardiovascular Surgery, Graduate School of Medicine, University of the Ryukyus, Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan.
    Background: Avoiding various complications is a challenge during re-do thoracoabdominal aneurysm surgery.

    Case Presentation: A 56-year-old man had undergone surgery for type I aortic dissection four times. The residual thoracoabdominal aortic aneurysm that had severe adhesions to lung parenchyma was resected. Read More

    Evaluation of conventional and frozen elephant trunk techniques on spinal cord blood flow in an animal model†.
    Eur J Cardiothorac Surg 2017 May 18. Epub 2017 May 18.
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany.
    Objectives: The treatment of patients with extensive thoracic aortic disease involving the arch and descending aorta is often performed using the frozen elephant trunk technique (FET). Spinal cord blood flow (SCBF) in cervical, thoracic and lumbar sections prior, during and after aortic arch surgery were compared in conventional elephant trunk (cET) and FET technique in a pig model.

    Methods: German Landrace pigs (75-85 kg) underwent aortic arch surgery using the FET ( n  = 8) or cET ( n  = 8) techniques. Read More

    Intracoronary Hypothermia Before Reperfusion to Reduce Reperfusion Injury in Acute Myocardial Infarction: A Novel Hypothesis and Technique.
    Ther Hypothermia Temp Manag 2017 May 18. Epub 2017 May 18.
    1 Department of Cardiology, Catharina Hospital , Eindhoven, the Netherlands .
    Because current reperfusion strategies in acute myocardial infarction (AMI) seem to be exhausted in terms of additional mortality benefit, there remains a need for new methods to attenuate reperfusion injury and, thereby, further reduce myocardial infarct size and improve long-term survival. Therapeutic hypothermia (32-35°C) diminishes reperfusion injury and reduces infarct size in a variety of animal models of AMI if provided before reperfusion. In human studies this reduction has not been confirmed so far, most likely because systemic cooling acts slowly, and therefore, the target temperature is not reached in time or at all in a substantial number of patients. Read More

    Therapeutic dormancy to delay postsurgical glioma recurrence: the past, present and promise of focal hypothermia.
    J Neurooncol 2017 May 17. Epub 2017 May 17.
    BrainTech Lab, INSERM U1205, CEA, Grenoble, France.
    Surgery precedes both radiotherapy and chemotherapy as the first-line therapy for glioma. However, despite multimodal treatment, most glioma patients die from local recurrence in the resection margin. Glioma surgery is inherently lesional, and the response of brain tissue to surgery includes hemostasis, angiogenesis, reactive gliosis and inflammation. Read More

    Technical Note: System for Evaluating Local Hypothermia as a Radioprotector of the Rectum in a Small Animal Model.
    Med Phys 2017 May 17. Epub 2017 May 17.
    Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA.
    Purpose: The protective effects of induced or even accidental hypothermia on the human body are widespread with several medical uses currently under active research. In vitro experiments using human cell lines have shown hypothermia provides a radioprotective effect that becomes more pronounced at large, single-fraction doses common to stereotactic body radiotherapy (SBRT) and stereotactic radiosurgery (SRS) treatments. This work describes the development of a system to evaluate local hypothermia for a radioprotive effect of the rat rectum during a large dose of radiation relevant to prostate SBRT. Read More

    Routine Laboratory Indices as Predictor of Neurological Recovery in Post-Resuscitation Syndrome Patients Treated with Therapeutic Hypothermia.
    Isr Med Assoc J 2017 May;19(5):296-299
    Department of Cardiology, Assaf Harofeh Medical Center, Zerifin, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Hypothermia is associated with improved outcome in selected survivors of cardiac arrest but no single metric enables proper prediction of neurological outcome.

    Objectives: To explored the association between routine laboratory indices of patients treated by hypothermia for cardiac arrest and their neurological outcome.

    Methods: We retrospectively collected data from survivors of cardiac arrest treated with hypothermia for 24 hours and grouped them according to their neurological outcome to either "poor" or "favorable". Read More

    Insufficient Humidification of Respiratory Gases in Patients Who Are Undergoing Therapeutic Hypothermia at a Paediatric and Adult Intensive Care Unit.
    Can Respir J 2017 20;2017:8349874. Epub 2017 Apr 20.
    Department of Paediatrics and Child Health, Kurume University School of Medicine, Fukuoka, Japan.
    For cooled newborn infants, humidifier settings for normothermic condition provide excessive gas humidity because absolute humidity at saturation is temperature-dependent. To assess humidification of respiratory gases in patients who underwent moderate therapeutic hypothermia at a paediatric/adult intensive care unit, 6 patients were studied over 9 times. Three humidifier settings, 37-default (chamber-outlet, 37°C; Y-piece, 40°C), 33. Read More

    Induction of hibernation-like hypothermia by central activation of the A1 adenosine receptor in a non-hibernator, the rat.
    J Physiol Sci 2017 May 15. Epub 2017 May 15.
    Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
    Central adenosine A1-receptor (A1AR)-mediated signals play a role in the induction of hibernation. We determined whether activation of the central A1AR enables rats to maintain normal sinus rhythm even after their body temperature has decreased to less than 20 °C. Intracerebroventricular injection of an adenosine A1 agonist, N6-cyclohexyladenosine (CHA), followed by cooling decreased the body temperature of rats to less than 20 °C. Read More

    COOL AMI EU pilot trial: a multicentre, prospective, randomised controlled trial to assess cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction.
    EuroIntervention 2017 May 17. Epub 2017 May 17.
    University Medical Center Ljubljana, Ljubljana, Slovenia.
    Aims: We aimed to investigate the rapid induction of therapeutic hypothermia using the ZOLL Proteus Intravascular Temperature Management System in patients with anterior ST-elevation myocardial infarction (STEMI) without cardiac arrest.

    Methods And Results: A total of 50 patients were randomised; 22 patients (88%; 95% confidence interval [CI]: 69-97%) in the hypothermia group and 23 patients (92%; 95% CI: 74-99) in the control group completed cardiac magnetic resonance imaging at four to six days and 30-day follow-up. Intravascular temperature at coronary guidewire crossing after 20. Read More

    A Novel Cooling Method and Comparison of Active Rewarming of Mildly Hypothermic Subjects.
    Wilderness Environ Med 2017 May 11. Epub 2017 May 11.
    Department of Biology, Stanford University (Drs Grahn and Heller).
    Objective: To compare the effectiveness of arteriovenous anastomosis (AVA) vs heated intravenous fluid (IVF) rewarming in hypothermic subjects. Additionally, we sought to develop a novel method of hypothermia induction.

    Methods: Eight subjects underwent 3 cooling trials each to a mean core temperature of 34. Read More

    How long is sufficient for optimal neuroprotection with cerebral cooling after ischemia in fetal sheep?
    J Cereb Blood Flow Metab 2017 Jan 1:271678X17707671. Epub 2017 Jan 1.
    Department of Physiology, The University of Auckland, Auckland, New Zealand.
    The optimal duration of mild "therapeutic" hypothermia for neonates with hypoxic-ischemic encephalopathy is surprisingly unclear. This study assessed the relative efficacy of cooling for 48 h versus 72 h. Fetal sheep (0. Read More

    Deep and profound hypothermia in haemorrhagic shock, friend or foe? A systematic review.
    J R Army Med Corps 2017 May 11. Epub 2017 May 11.
    University of Leicester Medical School, Centre for Medicine, Leicester, UK.
    Introduction: Survival in exsanguinating cardiac arrest patients is poor, as is neurological outcome in survivors. Hypothermia has traditionally been seen as harmful to trauma patients and associated with increased mortality; however, there has been speculation that cooling to very low temperatures (≤20°C) could be used to treat haemorrhagic trauma patients by the induction of a suspended animation period through extreme cooling, which improves survival and preserves neurological function. This has been termed emergency preservation and resuscitation (EPR). Read More

    Trends in Management and Mortality in Adults Hospitalized With Cardiac Arrest in the United States.
    J Intensive Care Med 2017 Jan 1:885066617707921. Epub 2017 Jan 1.
    3 Division of Cardiology, Department of Medicine, Stony Brook University Medical Center, Stony Brook, NY, USA.
    Background: We sought to examine temporal trends in management (ie, use of extracorporeal membrane oxygenation [ECMO], therapeutic hypothermia [TH], coronary angiogram, and percutaneous coronary intervention [PCI]) and in-hospital mortality in adults hospitalized with cardiac arrest.

    Methods: Utilizing the Nationwide Inpatient Sample, medical history, clinical management, and in-hospital mortality were assessed in 942 495 hospitalizations in adults with cardiac arrest (identified through International Classification of Diseases-9 codes) from 2006 to 2012.

    Results: From 2006 to 2012, there was an overall rise in the use of coronary angiogram (12. Read More

    Fast therapeutic hypothermia prevents post-cardiac arrest syndrome through cyclophilin D-mediated mitochondrial permeability transition inhibition.
    Basic Res Cardiol 2017 Jul 10;112(4):35. Epub 2017 May 10.
    Hospices Civils de Lyon, Hôpital Edouard Herriot, Service de Réanimation Médicale, 5 Place d'Arsonval, 69437, Lyon Cedex 03, France.
    The opening of the mitochondrial permeability transition pore (PTP), which is regulated by the matrix protein cyclophilin D (CypD), plays a key role in the pathophysiology of post-cardiac arrest (CA) syndrome. We hypothesized that therapeutic hypothermia could prevent post-CA syndrome through a CypD-mediated PTP inhibition in both heart and brain. In addition, we investigated whether specific pharmacological PTP inhibition would confer additive protection to cooling. Read More

    [Effect of acupuncture combined with hypothermia on MAPK/ERK pathway and apoptosis related factors in rats with cerebral ischemia reperfusion injury].
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017 Apr;42(4):380-388
    School of Acupuncture-Moxibustion and Tuina, Hunan University of Chinese Medicine, Changsha 410208, China.
    Objective: To observe effect of acupuncture combined with hypothermia therapy on MAPK/ERK pathway and apoptosis related factorsin rats suffered cerebral ischemia reperfusion and to explore underlying mechanisms.
 Methods: Middle cerebral artery ischemia model were established.Ninety SD rats were randomly assigned into a blank group, a control group, a model group, an acupuncture group, a mild hypothermia group, and an acupuncture with hypothermia group. Read More

    Practice guideline summary: Reducing brain injury following cardiopulmonary resuscitation: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.
    Neurology 2017 May 10. Epub 2017 May 10.
    From the Departments of Neurology, Anesthesiology-Critical Care Medicine, and Neurosurgery (R.G.G.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (E.W., A.R.), Mayo Clinic, Rochester, MN; Department of Neurology (M.J.A.), University of Florida-McKnight Brain Institute, Gainesville; Department of Neurology and Neurocritical Care Unit (M.D.), Cambridge University Hospitals; The Ipswich Hospital (M.D.), Cambridge, UK; Departments of Neurology and Neurosurgery (S.A.M.), Mount Sinai-Icahn School of Medicine, New York, NY; Departments of Emergency Medicine and Internal Medicine (Cardiology) (J.P.O.), Virginia Commonwealth University College of Medicine, Richmond; Department of Neurology (J.I.S.), Baylor College of Medicine, Houston, TX; Department of Neurology and Neurosurgery (M.T.T.), Ohio State University, Columbus; Department of Neurology (R.M.D.), Kansas University Medical Center, Kansas City; and Department of Neurology (J.L.), University of Toronto, Canada.
    Objective: To assess the evidence and make evidence-based recommendations for acute interventions to reduce brain injury in adult patients who are comatose after successful cardiopulmonary resuscitation.

    Methods: Published literature from 1966 to August 29, 2016, was reviewed with evidence-based classification of relevant articles.

    Results And Recommendations: For patients who are comatose in whom the initial cardiac rhythm is either pulseless ventricular tachycardia (VT) or ventricular fibrillation (VF) after out-of-hospital cardiac arrest (OHCA), therapeutic hypothermia (TH; 32-34°C for 24 hours) is highly likely to be effective in improving functional neurologic outcome and survival compared with non-TH and should be offered (Level A). Read More

    A novel scoring system for predicting the neurologic prognosis prior to the initiation of induced hypothermia in cases of post-cardiac arrest syndrome: the CAST score.
    Scand J Trauma Resusc Emerg Med 2017 May 10;25(1):49. Epub 2017 May 10.
    Department of Biostatistics, Nagoya University Graduate School of Medicine, Tsurumai-cho 65, Syowa-ku, Nagoya, Aichi, 4668560, Japan.
    Background: The aim of this study was to develop a scoring system for identifying the post-cardiac arrest syndrome (PCAS) patients with a good potential for recovery prior to the initiation of induced therapeutic hypothermia.

    Methods: A multi-center, retrospective, observational study was performed. Data of a total of 151 consecutive adults who underwent induced hypothermia after cardiac arrest (77 learning cases from two hospitals and 74 validation cases from two other hospitals) were analyzed. Read More

    Cord Blood IL-16 Is Associated with 3-Year Neurodevelopmental Outcomes in Perinatal Asphyxia and Hypoxic-Ischaemic Encephalopathy.
    Dev Neurosci 2017 May 11. Epub 2017 May 11.
    The Irish Centre for Foetal and Neonatal Translational Research (INFANT), Cork, Ireland.
    Activation of the inflammatory pathway is increasingly recognized as an important mechanism of injury following neonatal asphyxia and encephalopathy. This process may contribute to the poor prognosis seen in some cases, despite therapeutic hypothermia. Our group has previously identified raised interleukin (IL)-6 and IL-16, measured in umbilical cord blood at birth, to be predictive of grade of hypoxic-ischaemic encephalopathy (HIE). Read More

    Endovascular pulmonary artery inflatable balloon-induced hypotension: A novel technique for clipping giant intracranial aneurysms.
    Neurol India 2017 May-Jun;65(3):566-569
    Institutes of Neurosciences, SIMS Hospitals, Chennai, Tamil Nadu, India.
    Management of giant intracranial aneurysms presents unique challenges to the neurosurgical team. Various techniques such as adenosine-induced hypotension, rapid ventricular pacing, and inducing deep hypothermia are described in the literature to effect circulatory arrest for the successful obliteration of giant aneurysms. We describe a novel technique of induced hypotension for clipping a giant aneurysm by using an inflatable balloon across the main pulmonary artery with a successful outcome. Read More

    Pediatric Drowning: A Standard Operating Procedure to Aid the Prehospital Management of Pediatric Cardiac Arrest Resulting From Submersion.
    Pediatr Emerg Care 2017 May 8. Epub 2017 May 8.
    From the *Cardiff University School of Medicine; †Institute of Medicine Education, Cardiff, Wales; ‡St Anne's College, University of Oxford, Oxford, England; §Department of Cardiology, St George's Hospital, Tooting, London; and ∥Emergency Medical Retrieval and Transfer Service, Llanelli, Wales, United Kingdom.
    Objectives: Drowning is one of the leading causes of death in children. Resuscitating a child following submersion is a high-pressure situation, and standard operating procedures can reduce error. Currently, the Resuscitation Council UK guidance does not include a standard operating procedure on pediatric drowning. Read More

    Long-Term Neuropathological Changes Associated with Cerebral Palsy in a Nonhuman Primate Model of Hypoxic-Ischemic Encephalopathy.
    Dev Neurosci 2017 May 10. Epub 2017 May 10.
    Division of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA, USA.
    Background: Cerebral palsy (CP) is the most common motor disability in childhood, with a worldwide prevalence of 1.5-4/1,000 live births. Hypoxic-ischemic encephalopathy (HIE) contributes to the burden of CP, but the long-term neuropathological findings of this association remain limited. Read More

    Battlefield Trauma-Induced Hypothermia: Transitioning the Preferred Method of Casualty Rewarming.
    Wilderness Environ Med 2017 May 5. Epub 2017 May 5.
    Department of Surgery, Center for Translational Injury Research, University of Texas Health Science Center, Houston, Texas (Holcomb).
    For centuries, cold and wet weather has affected military combat operations leading to tremendous loss of manpower caused by cold-weather-related injuries including trench foot, frostbite, and hypothermia. The initial battlefield management of hypothermia in military personnel had not advanced significantly following many wars and conflicts until 2006. The aim of this review is to: 1) provide an overview of trauma-induced hypothermia (TIH); 2) highlight the Department of Defense strategy for the implementation of a hypothermia clinical management program for battlefield (prehospital) casualties; 3) highlight the research and development of the Hypothermia Prevention and Management Kit (HPMK) as the preferred field rewarming system for battlefield TIH; and 4) emphasize how the HPMK can be easily transitioned to the civilian sector for active rewarming of both accidental and TIH patients. Read More

    A Population Pharmacokinetic Analysis to Study the Effect of Therapeutic Hypothermia on Vancomycin Disposition in Children Resuscitated From Cardiac Arrest.
    Pediatr Crit Care Med 2017 May 5. Epub 2017 May 5.
    1Center for Clinical Pharmacology, The Children's Hospital of Philadelphia, Philadelphia, PA. 2Department of Pharmacy, Nemours Alfred I. DuPont Hospital for Children, Wilmington, DE. 3Metrum Research Group, Tariffville, CT. 4Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA.
    Objectives: Limited data exist on the effects of therapeutic hypothermia on renal function and pharmacokinetics in pediatric patients after cardiac arrest. The objective was to describe the differences in vancomycin disposition in pediatric patients following cardiac arrest treated with either therapeutic hypothermia or normothermia using population pharmacokinetic modeling.

    Design: Single-center, retrospective cohort study. Read More

    The beneficial hemodynamic effects of afterload reduction by sodium nitroprusside during rewarming from experimental hypothermia.
    Cryobiology 2017 May 4. Epub 2017 May 4.
    Anesthesia and Critical Care Research Group, Department of Clinical Medicine, UiT, The Arctic University of Norway, 9037 Tromsø, Norway; Division of Surgical Medicine and Intensive Care, University Hospital of North Norway, 9038 Tromsø, Norway. Electronic address:
    Background: Rewarming from hypothermia is associated with depressed cardiac function, known as hypothermia-induced cardiac dysfunction (HCD), and increased systemic vascular resistance (SVR). Previous studies on pharmacological treatment of HCD have demonstrated beneficial effects when using drugs with the combined effects; cardiac inotropic support and peripheral vasodilation. The presented study aims to investigate the isolated effects of arterial dilatation on cardiac functional variables during rewarming from hypothermia using sodium nitroprusside (SNP). Read More

    The Frequency and Severity of Magnetic Resonance Imaging Abnormalities in Infants with Mild Neonatal Encephalopathy.
    J Pediatr 2017 May 4. Epub 2017 May 4.
    Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA.
    Objective: To assess and contrast the incidence and severity of abnormalities on cerebral magnetic resonance imaging (MRI) between infants with mild, moderate, and severe neonatal encephalopathy who received therapeutic hypothermia.

    Study Design: This retrospective cohort studied infants with mild, moderate, and severe neonatal encephalopathy who received therapeutic hypothermia at a single tertiary neonatal intensive care unit between 2013 and 2015. Two neuroradiologists masked to the clinical condition evaluated brain MRIs for cerebral injury after therapeutic hypothermia using the Barkovich classification system. Read More

    Sinoaortic denervation attenuates vasopressin-induced hypothermia and reduction of sympathetic nerve activity innervating brown adipose tissue in rats.
    J Therm Biol 2017 May 19;66:10-16. Epub 2017 Mar 19.
    Thermoregulation and Inflammation Laboratory, Chengdu Medical College, Chengdu, Sichuan 610500, China.
    It is well known that sympathetic nerve activity innervating brown adipose tissue (BAT sympathetic nerve activity) plays an important role in BAT thermogenesis. We have found that peripheral administration of arginine vasopressin (AVP) induced hypothermia by reduced thermogenesis in BAT. However, little is known about AVP-induced hypothermic response and its relationship with BAT sympathetic nerve activity. Read More

    Disseminated intravascular coagulation is associated with the neurologic outcome of cardiac arrest survivors.
    Am J Emerg Med 2017 May 1. Epub 2017 May 1.
    Department of Emergency Medicine, Chonnam National University Hospital, 42 Jebong-ro, Donggu, Gwangju, Republic of Korea.
    Purpose: We aimed to examine the serial changes in coagulofibrinolytic markers that occurred after the restoration of spontaneous circulation (ROSC) in cardiac arrest patients, who were treated with targeted temperature management (TTM). We also evaluated the association between the disseminated intravascular coagulation (DIC) score and clinical outcomes.

    Methods: This was a single-centre, retrospective observational study that included cardiac arrest patients who were treated with TTM from May 2012 to December 2015. Read More

    Hypothermia-induced dystonia and abnormal cerebellar activity in a mouse model with a single disease-mutation in the sodium pump.
    PLoS Genet 2017 May 4;13(5):e1006763. Epub 2017 May 4.
    Department of Biomedicine, Aarhus University, Aarhus, Denmark.
    Mutations in the neuron-specific α3 isoform of the Na+/K+-ATPase are found in patients suffering from Rapid onset Dystonia Parkinsonism and Alternating Hemiplegia of Childhood, two closely related movement disorders. We show that mice harboring a heterozygous hot spot disease mutation, D801Y (α3+/D801Y), suffer abrupt hypothermia-induced dystonia identified by electromyographic recordings. Single-neuron in vivo recordings in awake α3+/D801Y mice revealed irregular firing of Purkinje cells and their synaptic targets, the deep cerebellar nuclei neurons, which was further exacerbated during dystonia and evolved into abnormal high-frequency burst-like firing. Read More

    Hyperoxia or Therapeutic Hypothermia During Resuscitation from Non-Lethal Hemorrhagic Shock in Swine.
    Shock 2017 May 2. Epub 2017 May 2.
    *Klinik für Anästhesiologie, Universitätsklinikum Ulm, Ulm, Germany †Institut für Anästhesiologische Pathophysiologie und Verfahrensentwicklung, Universitätsklinikum Ulm, Ulm, Germany ‡Institut für Pathologie, Universitätsklinikum Ulm, Ulm, Germany §Abteilung X Anästhesie und Intensivmedizin, Bundeswehrkrankenhaus Ulm, Ulm, Germany ||Department of Internal Medicine I, Biomedical Centre and Karlova Univerzita Praha, Plzeň, Czech Republic ¶CNRS UMR 6214, INSERM U1083, Université Angers, Angers, France **Département de Réanimation Médicale et de Médecine Hyperbare, Centre Hospitalier Universitaire, Angers, France.
    We previously demonstrated beneficial effects of 22 h of hyperoxia following near-lethal porcine hemorrhagic shock, whereas therapeutic hypothermia was detrimental. Therefore, we investigated whether shorter exposure to hyperoxia (12 h) would still improve organ function, and whether 12 h of hypothermia with subsequent rewarming could avoid deleterious effects after less severe hemorrhagic shock.Twenty-seven anesthetized and surgically instrumented pigs underwent 3 hours of hemorrhagic shock by removal of 30% of the blood volume and titration of the mean arterial blood pressure (MAP) to 40mmHg. Read More

    Relationships between cerebral autoregulation and markers of kidney and liver injury in neonatal encephalopathy and therapeutic hypothermia.
    J Perinatol 2017 May 4. Epub 2017 May 4.
    Neurosciences Intensive Care Nursery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
    Objective: We studied whether cerebral blood pressure autoregulation and kidney and liver injuries are associated in neonatal encephalopathy (NE).

    Study Design: We monitored autoregulation of 75 newborns who received hypothermia for NE in the neonatal intensive care unit to identify the mean arterial blood pressure with optimized autoregulation (MAPOPT). Autoregulation parameters and creatinine, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were analyzed using adjusted regression models. Read More

    [Management of Massive Intraoperative Blood Loss Using a Case Study].
    Anasthesiol Intensivmed Notfallmed Schmerzther 2017 Apr 3;52(4):288-296. Epub 2017 May 3.
    Massive intraoperative bleeding is a major and potentially life-threatening complication during surgical procedures. The lethal triade of hemorrhagic shock with metabolic acidosis, hypothermia and coagulopathy enhances bleeding tendency. Avoiding this vitious circle requires a well-structured and standardized procedure. Read More

    Neuroprotective mechanisms and translational potential of therapeutic hypothermia in the treatment of ischemic stroke.
    Neural Regen Res 2017 Mar;12(3):341-350
    Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, USA; Veteran's Affair Medical Center, Center for Visual and Neurocognitive Rehabilitation, Atlanta, GA, USA.
    Stroke is a leading cause of disability and death, yet effective treatments for acute stroke has been very limited. Thus far, tissue plasminogen activator has been the only FDA-approved drug for thrombolytic treatment of ischemic stroke patients, yet its application is only applicable to less than 4-5% of stroke patients due to the narrow therapeutic window (< 4.5 hours after the onset of stroke) and the high risk of hemorrhagic transformation. Read More

    Hypothalamic or Extrahypothalamic Modulation and Targeted Temperature Management After Brain Injury.
    Ther Hypothermia Temp Manag 2017 May 3. Epub 2017 May 3.
    1 Department of Neurosurgery, University of Maryland School of Medicine , Baltimore, Maryland.
    Targeted temperature management (TTM) has been recognized to protect tissue function and positively influence neurological outcomes after brain injury. While shivering during hypothermia nullifies the beneficial effect of TTM, traditionally, antishivering drugs or paralyzing agents have been used to reduce the shivering. The hypothalamic area of the brain helps in controlling cerebral temperature and body temperature through interactions between different brain areas. Read More

    Mild induced hypothermia and survival after out-of-hospital cardiac arrest in a Swedish urban area.
    Am J Emerg Med 2017 Apr 27. Epub 2017 Apr 27.
    Department of Anesthesiology and Intensive Care Medicine, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Background: Mild induced hypothermia (MIH) was introduced for post cardiac arrest care in Sweden in 2003, based on two clinical trials. This retrospective study evaluated its association with 30-day survival after out-of-hospital cardiac arrest (OHCA) in a Swedish community from 2003 to 2015.

    Methods: Out of 3680 patients with OHCA, 1100 were hospitalized after return of spontaneous circulation and 871 patients who remained unconscious were included in the analysis. Read More

    Spheroidal formation preserves human stem cells for prolonged time under ambient conditions for facile storage and transportation.
    Biomaterials 2017 Jul 18;133:275-286. Epub 2017 Apr 18.
    Faculty of Health Sciences, University of Macau, Taipa, Macau. Electronic address:
    Human stem cells are vulnerable to unfavorable conditions, and their transportation relies on costly and inconvenient cryopreservation. We report here that human mesenchymal stem cells (MSC) in spheroids survived ambient conditions (AC) many days longer than in monolayer. Under AC, the viability of MSC in spheroids remained >90% even after seven days, whereas MSC in monolayer mostly died fast. Read More

    A systematic surgical approach to hepatoblastoma with intracardiac extension.
    Asian Cardiovasc Thorac Ann 2017 May 29;25(4):300-303. Epub 2017 Apr 29.
    1 Queensland Paediatric Cardiac Services, Lady Cilento Children's Hospital, Brisbane, Australia.
    Hepatoblastoma is very uncommon in children, and intracardiac extension is rare. The SIOPEL-4 regime for metastatic hepatoblastoma has extended the surgical options with good results. We successfully treated a boy aged 2 years and 9 months with hepatoblastoma, using a multidisciplinary surgical strategy involving an extended left hepatectomy, left adrenalectomy, biopsy of the paraaortic and coeliac lymph nodes, and resection of the inferior vena caval-right atrial extension of the hepatoblastoma, under cardiopulmonary bypass and deep hypothermia. Read More

    Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome.
    J Pediatr 2017 Apr 26. Epub 2017 Apr 26.
    University of California San Francisco, San Francisco, CA.
    In the Neonatal Erythropoietin and Therapeutic Hypothermia Outcomes study, 9/20 erythropoietin-treated vs 12/24 placebo-treated infants with hypoxic-ischemic encephalopathy had acute brain injury. Among infants with acute brain injury, the injury volume was lower in the erythropoietin than the placebo group (P = .004). Read More

    Effect of mild hypothermia preconditioning against low temperature (4°C) induced rat liver cell injury in vitro.
    PLoS One 2017 28;12(4):e0176652. Epub 2017 Apr 28.
    Second Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, P.R. China.
    Bioartificial liver holds special position in the field of regenerative medicine, and cold environment at 4℃ is widely used for the short storage of both organ and liver cell for later application. However, the disadvantages of such cold storage could influence cell viability and lead to cell apoptosis in different degrees. In this study, we mainly explore the pre-protective effect of mild hypothermia against low temperature (4℃)-induced rat liver cell injury in vitro. Read More

    Optimization of brain metabolism using metabolic-targeted therapeutic hypothermia can reduce mortality from traumatic brain injury.
    J Trauma Acute Care Surg 2017 Apr 27. Epub 2017 Apr 27.
    From Department of Trauma Surgery (J.F., W.W., J.Z., S.L., H.J.), Sichuan Provincial People's Hospital, Sichuan Academy of Medical Sciences, Chengdu, China; Department of Computational Mathematics and Biostatistics (W.W., J.Z., Z.Z., J.P., H.Y., C.D.L., H.J.), Metabolomics and Multidisciplinary Laboratory for Trauma Research, Sichuan Provincial People's Hospital, Sichuan Academy of Medical Sciences, Chengdu, China; North Sichuan Medical College (W.W.), Nanchong, China; Department of Biochemistry (Z.Z.), Southwest Medical University, Luzhou, China; Analytical & Testing Center (P.D.), Sichuan University, Chengdu, China.
    Background: Therapeutic hypothermia is widely used to treat traumatic brain injuries (TBIs). However, determining the best hypothermia therapy strategy remains a challenge. We hypothesized that reducing the metabolic rate, rather than reaching a fixed body temperature, would be an appropriate target as optimizing metabolic conditions especially the brain metabolic environment may enhance neurologic protection. Read More

    Emulsified isoflurane combined with therapeutic hypothermia improves survival and neurological outcomes in a rat model of cardiac arrest.
    Exp Ther Med 2017 Mar 13;13(3):891-898. Epub 2017 Jan 13.
    Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
    Emulsified isoflurane (EIso), when introduced following cardiopulmonary resuscitation (CPR), significantly improves survival and neurological outcomes in a rat model of cardiac arrest (CA). The present study aimed to examine whether EIso combined with therapeutic hypothermia (TH) confers an additive neuroprotective effect. Adult male Sprague-Dawley rats that were subjected to return of spontaneous circulation (ROSC) after a 6-min asphyxia-induced CA were randomized to five groups: Sham group, control group under normothermic conditions, EIso group (4 ml/kg for 30 min under normothermic conditions), TH group (33°C for 2 h), and EIso plus TH group. Read More

    Neuroprotective Treatments after Perinatal Hypoxic-Ischemic Brain Injury Evaluated with Magnetic Resonance Spectroscopy.
    Dev Neurosci 2017 Apr 28. Epub 2017 Apr 28.
    Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
    Perinatal hypoxic-ischemic brain injury is a major health problem. Adjuvant treatments that improve the neuroprotective effect of the current treatment, therapeutic hypothermia, are urgently needed. The growing knowledge about the complex pathophysiology of hypoxia-ischemia (HI) has led to the discovery of several important targets for neuroprotection. Read More

    Neuromuscular blockade requirement is associated with good neurologic outcome in cardiac arrest survivors treated with targeted temperature management.
    J Crit Care 2017 Apr 19;40:218-224. Epub 2017 Apr 19.
    Department of Emergency Medicine, Chonnam National University Hospital, 42 Jebong-ro, Donggu, Gwangju, Republic of Korea.
    Purpose: We examined the association between neuromuscular blockade (NMB) requirements and outcomes and lactate clearance in cardiac arrest survivors treated with targeted temperature management (TTM).

    Methods: We included consecutive adult cardiac arrest survivors treated with TTM between 2012 and 2015. NMB use was categorized into 3 groups: no NMB, bolus NMB (intermittent bolus use), and continuous NMB (continuous infusion). Read More

    [Severe accidental hypothermia : Treatment using an intravascular temperature management catheter].
    Med Klin Intensivmed Notfmed 2017 Apr 26. Epub 2017 Apr 26.
    Abteilung für Kardiologie, Robert-Bosch-Krankenhaus, Auerbachstraße 110, 70376, Stuttgart, Deutschland.
    Different techniques have been reported for the treatment of severe accidental hypothermia. In this case, we successfully used an intravascular catheter temperature management system which has been developed to induce reversible therapeutic hypothermia in patients following resuscitation. In our patient, the initial core temperature was 26. Read More

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