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    TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: compounds' pharmacological profiles, in-vivo targets, thermoeffectors recruited, and implications for drug development.
    Acta Physiol (Oxf) 2018 Jan 20. Epub 2018 Jan 20.
    Systemic Inflammation Laboratory (FeverLab), Trauma Research, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
    Aim: Thermoregulatory side effects hinder the development of transient receptor potential vanilloid-1 (TRPV1) antagonists as new painkillers. While many antagonists cause hyperthermia, a well-studied effect, some cause hypothermia. The mechanisms of this hypothermia are unknown and were studied herein. Read More

    Inhibition of dynamin-related protein 1 has neuroprotective effect comparable with therapeutic hypothermia in a rat model of cardiac arrest.
    Transl Res 2018 Jan 8. Epub 2018 Jan 8.
    Department of Emergency Medicine, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China; Institute of Cardiopulmonary Cerebral Resuscitation, Sun Yat-sen University, Guangzhou, China; Weil Institute of Emergency and Critical Care Research, School of Medicine, Virginia Commonwealth University, Richmond, Virginia; Department of Emergency Medicine, Virginia Commonwealth University, Richmond, Virginia. Electronic address:
    Dynamin-related protein 1 (Drp1) regulates mitochondrial fission, it has been proven that inhibition of Drp1 by mdivi-1 improves survival and attenuates cerebral ischemic injury after cardiac arrest. In this study, we compared the effects of Drp1 inhibition with therapeutic hypothermia on post-resuscitation neurologic injury in a rat model of cardiac arrest. Rats were randomized into 4 groups: Mdivi-1 treatment group (n = 39), hypothermic group (n = 38), normothermic group (n = 41), and sham group (n = 12). Read More

    Dose-Dependent Cardioprotection of Moderate (32°C) Versus Mild (35°C) Therapeutic Hypothermia in Porcine Acute Myocardial Infarction.
    JACC Cardiovasc Interv 2018 Jan;11(2):195-205
    Division of Cardiovascular Medicine, Stanford University, Stanford, California; Cardiovascular Institute, Stanford University, Stanford, California.
    Objectives: The study investigated whether a dose response exists between myocardial salvage and the depth of therapeutic hypothermia.

    Background: Cardiac protection from mild hypothermia during acute myocardial infarction (AMI) has yielded equivocal clinical trial results. Rapid, deeper hypothermia may improve myocardial salvage. Read More

    Blood biomarkers for evaluation of perinatal encephalopathy: state of the art.
    Curr Opin Pediatr 2018 Jan 17. Epub 2018 Jan 17.
    The Neuroscience Intensive Care Nursery program is multidisciplinary and contains members from numerous departments.
    Purpose Of Review: The rapid progress in biomarker science is on the threshold of significantly changing clinical care for infants in the neonatal ICU. Infants with neonatal brain injuries will likely be the first group whose management is dramatically altered with point-of-care, rapidly available brain biomarker analysis. Providing an interim update on progress in this area is the purpose of this review. Read More

    Successful Use of Therapeutic Hypothermia for Refractory Nonconvulsive Status Epilepticus.
    J Epilepsy Res 2017 Dec 31;7(2):109-114. Epub 2017 Dec 31.
    Department of Neurology, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
    Therapeutic hypothermia (TH) has rarely been utilized as an adjunct to anticonvulsants in treating patients with refractory convulsive status epilepticus (CSE). However, determining the effectiveness of TH in CSE is difficult due to the unavoidable use of sedative drugs to manage hypothermia. Additionally, the effectiveness of TH has not been studied in patients with refractory non-convulsive status epilepticus (NCSE). Read More

    Novel dry cryotherapy system for cooling the equine digit.
    Vet Rec Open 2018 7;5(1):e000244. Epub 2018 Jan 7.
    Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania, USA.
    Objectives: Digital cryotherapy is commonly used for laminitis prophylaxis and treatment. Currently validated methods for distal limb cryotherapy involve wet application or compression technology. There is a need for a practical, affordable, dry cryotherapy method that effectively cools the digit. Read More

    Can Neonatal Brain MRI be Performed during Active Cooling?
    Am J Perinatol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Pediatrics, University of Florida, Gainesville, Florida.
    Objective:  Due to logistical constraints, physicians traditionally delay diagnostic imaging for neonatal hypoxic-ischemic encephalopathy (HIE) until the neonate has completed all 72 hours of therapeutic hypothermia and rewarming. In some cases, neonates may require neuroimaging before 72 hours has passed.

    Study Design:  We present a case in which an MRI was acquired during active hypothermia. Read More

    Anesthesia and Monitoring of Animals During MRI Studies.
    Methods Mol Biol 2018 ;1718:423-439
    Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.
    The use of imaging represents a major impact on the refinement and the reduction of in vivo studies in animal models, in particular for allowing longitudinal monitoring of the onset and the progression of disease within the same animal, and studying the biological effects of drug candidate and their therapeutic effectiveness. But the use of imaging procedures can affect animal physiology, and the need to anesthetize the animals for imaging entails potential health risks. During anesthesia, there is an inevitable autonomic nervous system depression which induces cardiovascular depression, respiratory depression, and hypothermia. Read More

    Neuroprotective effects of topiramate and memantine in combination with hypothermia in hypoxic-ischemic brain injury in vitro and in vivo.
    Neurosci Lett 2018 Jan 12;668:103-107. Epub 2018 Jan 12.
    Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Viale Pieraccini 6, 50139, Italy.
    Hypoxic-ischemic encephalopathy (HIE) is a major cause of perinatal mortality and subsequent severe neurological sequelae. Mild hypothermia is a standard therapy for HIE, but is used only in selected Reference Centers and in neonates >1800 g. Since neuronal death following HIE occurs by a cascade of events triggered by activation of glutamate receptors, we used in vitro and in vivo models of HIE to examine whether the AMPA/kainate receptor antagonist topiramate and the NMDA receptor antagonist memantine could exert neuroprotective effects, alone or in combination with hypothermia. Read More

    Noteworthy Articles in 2017 for Cardiothoracic Critical Care.
    Semin Cardiothorac Vasc Anesth 2018 Jan 1:1089253217753395. Epub 2018 Jan 1.
    3 University of Kansas Medical Center, Kansas City, KS, USA.
    In 2017, many high-impact articles appeared in the literature. This is the third edition of an annual review of articles related to postoperative cardiac critical care that may affect the cardiac anesthesiologist. This year explores vasopressor and inotropic support, timing of renal replacement therapy, management of postoperative respiratory insufficiency, and targeted temperature therapy. Read More

    Effect of therapeutic hypothermia on survival and neurological outcome in adults suffering cardiac arrest: a systematic review and meta-analysis.
    Minerva Anestesiol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Intensive Care, Alwasta Central Hospital, Beni Sweif, Egypt.
    Introduction: The aim of this review is to determine current evidence for the effect of therapeutic hypothermia (TH) on survival and neurological outcome in adults suffering cardiac arrest (CA).

    Evidence Aquisition: We searched the Cochrane Controlled Trials Register, MEDLINE, EMBASE and NLM databases from 2000 to 2017 using the following terms: hypothermia, cooling, therapeutic, cardiac arrest, resuscitation, cardiopulmonary, CPR. Studies were eligible if they compared TH versus normothermic management in adult humans sustaining CA. Read More

    The Effect of Therapeutic Mild Hypothermia on Brain Microvascular Endothelial Cells During Ischemia-Reperfusion Injury.
    Neurocrit Care 2018 Jan 11. Epub 2018 Jan 11.
    Department of Emergency Medicine, West China Hospital, Sichuan University, 37 Guoxue Road, Chengdu, 610041, Sichuan, China.
    Background: To determine the cerebral protective effects of mild hypothermia (MH) on cerebral microcirculation.

    Methods: We established ischemia-reperfusion (I/R) injury and MH treatment models with rat brain microvascular endothelial cells (RBMECs) in vitro and examined the apoptotic changes. The cultured RBMECs were randomly divided into the control group, I/R group, and MH group, which was further divided into two subgroups: intra-ischemia hypothermia (IIH) and post-ischemia hypothermia (PIH). Read More

    Effect and feasibility of therapeutic hypothermia in patients with hemorrhagic stroke: a systematic review and meta-analysis.
    World Neurosurg 2018 Jan 8. Epub 2018 Jan 8.
    Department of Neurosurgery, West China Hospital, Sichuan University and West China Brain Research Centre, West China Hospital, Sichuan University. Electronic address:
    Introduction: Therapeutic hypothermia (TH) has shown a good performance in the experimental hemorrhagic stroke. But the clinical application of TH remains controversial since reports regarding its therapeutic effect are inconsistent.

    Methods: We conducted a systematic review based on Preferred Reporting Items for Systematic Reviews and Meta-analyses. Read More

    Induced hypothermia in patients with septic shock and respiratory failure (CASS): a randomised, controlled, open-label trial.
    Lancet Respir Med 2018 Jan 8. Epub 2018 Jan 8.
    Centre of Excellence in Immunity and Infection/Centre of Excellence for Personalised Medicine of Infectious Complications in Immune Deficiency, Department of Infectious Diseases, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark; Respiratory Medicine Division, Department of Internal Medicine, Herlev and Gentofte Hospital, Hellerup, Denmark. Electronic address:
    Background: Animal models of serious infection suggest that 24 h of induced hypothermia improves circulatory and respiratory function and reduces mortality. We tested the hypothesis that a reduction of core temperature to 32-34°C attenuates organ dysfunction and reduces mortality in ventilator-dependent patients with septic shock.

    Methods: In this randomised, controlled, open-label trial, we recruited patients from ten intensive care units (ICUs) in three countries in Europe and North America. Read More

    Therapeutic hypothermia and myocardium in perinatal asphyxia: a microvolt T-wave alternans and Doppler echocardiography study.
    Bratisl Lek Listy 2017 ;118(12):765-771
    Objectives: This is the first study evaluating the predictive value of myocardial performance on arrhythmia and mortality via tissue-Doppler and microvolt T-wave alternans in infants with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia-rewarming.

    Methods: The study included 23 term newborns having criteria for hypoxic-ischemic encephalopathy, and 12 controls. Tissue-Doppler imaging and T-wave alternans were performed in the first six hours after birth in patients from both groups and after hypothermia-rewarming treatment on the fifth day. Read More

    Paediatric in-hospital cardiac arrest: Factors associated with survival and neurobehavioural outcome one year later.
    Resuscitation 2018 Jan 6;124:96-105. Epub 2018 Jan 6.
    University of Michigan, CS Mott Children's Hospital, 1540 East Hospital Drive, Ann Arbor, MI, 48109, USA.
    Objective: To investigate clinical characteristics associated with 12-month survival and neurobehavioural function among children recruited to the Therapeutic Hypothermia after Paediatric Cardiac Arrest In-Hospital trial.

    Methods: Children (n = 329) with in-hospital cardiac arrest who received chest compressions for ≥2 min, were comatose, and required mechanical ventilation after return of circulation were included. Neurobehavioural function was assessed using the Vineland Adaptive Behaviour Scales, second edition (VABS-II) at baseline (reflecting pre-arrest status) and 12 months post-arrest. Read More

    Predicting long-term outcomes after cardiac arrest by using serum neutrophil gelatinase-associated lipocalin.
    Am J Emerg Med 2017 Dec 7. Epub 2017 Dec 7.
    Department of Emergency Medicine, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea. Electronic address:
    Objectives: Neutrophil gelatinase-associated lipocalin (NGAL) is secreted by various tissues in pathologic states. Previous studies reported that post-cardiac arrest serum NGAL levels correlate with short-term neurologic outcomes and survival. The aim of this study was to examine the associations between NGAL levels post-cardiac arrest and long-term outcomes and survival. Read More

    Transcriptome Analysis of Gene Expression Provides New Insights into the Effect of Mild Therapeutic Hypothermia on Primary Human Cortical Astrocytes Cultured under Hypoxia.
    Front Cell Neurosci 2017 14;11:386. Epub 2017 Dec 14.
    Research Institute of Health Sciences, Wolverhampton School of Sciences, University of Wolverhampton, Wolverhampton, United Kingdom.
    Hypothermia is increasingly used as a therapeutic measure to treat brain injury. However, the cellular mechanisms underpinning its actions are complex and are not yet fully elucidated. Astrocytes are the most abundant cell type in the brain and are likely to play a critical role. Read More

    Pyruvate induces torpor in obese mice.
    Proc Natl Acad Sci U S A 2018 Jan 8. Epub 2018 Jan 8.
    Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215;
    Mice subjected to cold or caloric deprivation can reduce body temperature and metabolic rate and enter a state of torpor. Here we show that administration of pyruvate, an energy-rich metabolic intermediate, can induce torpor in mice with diet-induced or genetic obesity. This is associated with marked hypothermia, decreased activity, and decreased metabolic rate. Read More

    Use of therapeutic hypothermia among patients with coagulation disorders - A Nationwide analysis.
    Resuscitation 2018 Jan 3;124:35-42. Epub 2018 Jan 3.
    Department of Medicine, New York Medical College, Valhalla, NY, United States.
    Objectives: The study aimed to assess the impact of therapeutic hypothermia (TH) on bleeding and in-hospital mortality among patients with coagulation disorders (CD).

    Background: TH affects coagulation factors and platelets putting patients at risk for bleeding and worse outcomes. Effect of TH among patients with CD remains understudied. Read More

    An experimental study and finite element modeling of head and neck cooling for brain hypothermia.
    J Therm Biol 2018 Jan 4;71:99-111. Epub 2017 Nov 4.
    Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
    Reducing brain temperature by head and neck cooling is likely to be the protective treatment for humans when subjects to sudden cardiac arrest. This study develops the experimental validation model and finite element modeling (FEM) to study the head and neck cooling separately, which can induce therapeutic hypothermia focused on the brain. Anatomically accurate geometries based on CT images of the skull and carotid artery are utilized to find the 3D geometry for FEM to analyze the temperature distributions and 3D-printing to build the physical model for experiment. Read More

    Liver Graft Susceptibility during Static Cold Storage and Dynamic Machine Perfusion: DCD versus Fatty Livers.
    Int J Mol Sci 2017 Dec 31;19(1). Epub 2017 Dec 31.
    Department of Internal Medicine and Therapeutics, Unit of Cellular and Molecular Pharmacology and Toxicology, University of Pavia, 27100 Pavia, Italy.
    We compared static preservation (cold storage, CS, 4 °C) with dynamic preservation (machine perfusion, MP, 20 °C) followed by reperfusion using marginal livers: a model of donation after cardiac death (DCD) livers and two models of fatty livers, the methionine-choline deficient (MCD) diet model, and obese Zucker (fa/fa) rats. CS injury in DCD livers was reversed by an oxygenated washout (OW): hepatic damage, bile flow, and the ATP/ADP ratio in the OW + CS group was comparable with the ratio obtained with MP. Using fatty livers, CS preservation induced a marked release in hepatic and biliary enzymes in obese Zucker rats when compared with the MCD group. Read More

    No-touch aorta robot-assisted atrial septal defect repair via two ports.
    Interact Cardiovasc Thorac Surg 2018 Jan 2. Epub 2018 Jan 2.
    Department of Cardiovascular Surgery, NewHeart Watanabe Institute, Suginami-ku, Tokyo, Japan.
    Objectives: Atrial septal defect (ASD) repairs have been successfully performed on arrested hearts with robotic assistance. The present study assessed the feasibility, safety, and efficacy of totally endoscopic cardiac surgery using a no-touch aorta technique for ASD via only 2 ports, and we named this procedure two-port robotic cardiac surgery (TROCS).

    Methods: Between May 2014 and June 2016, 8 consecutive patients underwent TROCS for ASD using the da Vinci surgical system (Intuitive Surgical Inc. Read More

    Mild Contralesional Hypothermia Reduces Use of the Unimpaired Forelimb in a Skilled Reaching Task After Motor Cortex Injury in Rats.
    Ther Hypothermia Temp Manag 2018 Jan 3. Epub 2018 Jan 3.
    1 Neuroscience and Mental Health Institute, University of Alberta, Edmonton , Canada .
    Therapeutic hypothermia (TH) mitigates neuronal injury in models of ischemic stroke. Although this therapy is meant for injured tissue, most protocols cool the whole body, including the contralesional hemisphere. Neuroplasticity responses within this hemisphere can affect functional outcome. Read More

    Efficacy of different cooling technologies for therapeutic temperature management: A prospective intervention study.
    Resuscitation 2017 Dec 26;124:14-20. Epub 2017 Dec 26.
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA 15213, United States. Electronic address:
    Background: Mild therapeutic hypothermia (32-36 °C) is associated with improved outcomes in patients with brain injury after cardiac arrest (CA). Various devices are available to induce and maintain hypothermia, but few studies have compared the performance of these devices. We performed a prospective study to compare four frequently used cooling systems in inducing and maintaining hypothermia followed by controlled rewarming. Read More

    Cellular and Molecular Mechanisms Underlying Non-Pharmaceutical Ischemic Stroke Therapy in Aged Subjects.
    Int J Mol Sci 2017 Dec 29;19(1). Epub 2017 Dec 29.
    Gold Coast Campus, School of Medicine, Griffith University, Southport 4222, Australia.
    The incidence of ischemic stroke in humans increases exponentially above 70 years both in men and women. Comorbidities like diabetes, arterial hypertension or co-morbidity factors such as hypercholesterolemia, obesity and body fat distribution as well as fat-rich diet and physical inactivity are common in elderly persons and are associated with higher risk of stroke, increased mortality and disability. Obesity could represent a state of chronic inflammation that can be prevented to some extent by non-pharmaceutical interventions such as calorie restriction and hypothermia. Read More

    Review: Hibernation-Based Approaches in the Treatment of Hemorrhagic Shock.
    Shock 2017 Dec 27. Epub 2017 Dec 27.
    Department of Surgery, University of Minnesota, Minneapolis, MN, USA.
    Hemorrhagic shock is the leading cause of preventable death after trauma. Hibernation-based treatment approaches have been of increasing interest for various biomedical applications. Due to apparent similarities in tissue perfusion and metabolic activity between severe blood loss and the hibernating state, hibernation-based approaches have also emerged for the treatment of hemorrhagic shock. Read More

    Pediatric Hypothermic Submersion Injury and Protective Factors Associated with Optimal Outcome: A Case Report and Literature Review.
    Children (Basel) 2017 Dec 27;5(1). Epub 2017 Dec 27.
    Department of Pediatrics, Division Pediatric Critical Care, Neuro-Critical Care Program, Oregon Health and Science University, Portland, OR 97239, USA.
    Drowning is the 3rd leading cause of unintentional injury death worldwide, with the highest rates of fatality among young children. Submersion injuries with cardiac arrest can lead to long-term neurologic morbidity. Severe hypothermic submersion injuries have complex treatment courses and survivors have variable neurocognitive outcomes. Read More

    Mild hypothermia protects neurons against oxygen glucose deprivation via poly (ADP-ribose) signaling.
    J Matern Fetal Neonatal Med 2017 Dec 26:1-7. Epub 2017 Dec 26.
    a Department of Anaesthesiology , General Hospital of Ningxia Medical University , Yinchuan , China.
    Objective: Hypothermia is a neuroprotective mechanism that has been validated for use in alleviating neonatal hypoxic-ischemic (HI) brain injury. Nevertheless, it is unclear whether poly (ADP-ribose) (PAR) signaling is involved in hypothermia-induced neuroprotection. In this study, we investigated whether mild hypothermia rescues oxygen glucose deprivation (OGD)-induced cell death by modifying PAR-relative protein expression, such as AIF, PARP-1, and PAR polymer, in primary-cultured hippocampal neurons. Read More

    Shivering Treatments for Targeted Temperature Management: A Review.
    J Neurosci Nurs 2017 Dec 22. Epub 2017 Dec 22.
    Questions or comments about this article may be directed to Akash Jain, MBBS, at Medical Officer, Government of Rajasthan, India. Maria Gray, MA RN, is Vice President for Clinical Services, Attune Medical, Chicago, IL. Stephanie Slisz, BSN RN, is Senior Clinical Specialist, Attune Medical, Chicago, IL. Joseph Haymore, DNP ACNP, is Senior Nurse Practitioner and Advanced Practice Provider Research Director, Neurocritical Care Intensive Care Unit, University of Maryland Medical Center, Baltimore, Maryland. Neeraj Badjatia, MD, is Professor of Neurology and Vice Chair for Hospital Operations, Department of Neurology, University of Maryland School of Medicine and R Adams Cowley Shock Trauma Center, Baltimore, MD. Erik Kulstad, MD MS, is Associate Professor, Department of Emergency Medicine, University of Texas Southwestern Medical Center, Dallas, TX. E.K., S.S., and M.G. work with a company, Attune Medical, commercializing temperature management technology. For the remaining authors, no conflicts of interest were declared.
    Background: Shivering is common during targeted temperature management, and control of shivering can be challenging if clinicians are not familiar with the available options and recommended approaches.

    Purpose: The purpose of this review was to summarize the most relevant literature regarding various treatments available for control of shivering and suggest a recommended approach based on latest data.

    Methods: The electronic databases PubMed/MEDLINE and Google Scholar were used to identify studies for the literature review using the following keywords alone or in combination: "shivering treatment," "therapeutic hypothermia," "core temperature modulation devices," and "targeted temperature management. Read More

    Persistent hyperglycemia in a neonate: Is it a complication of therapeutic hypothermia?
    Turk J Pediatr 2017 ;59(2):193-196
    Divisions of Neonatology, Department of Pediatrics, Marmara University Faculty of Medicine, Istanbul, Turkey.
    Özdemir H, Memişoğlu A, Alp-Unkar Z, Arcagök B, Bilgen H, Turan S, Özek E. Persistent hyperglycemia in a neonate: Is it a complication of therapeutic hypothermia? Turk J Pediatr 2017; 59: 193-196. The aim of this report is to present a newborn with persistent hyperglycemia requiring insulin therapy as a possible complication of therapeutic hypothermia. Read More

    Neonatal Systemic Inflammation Induces Inflammatory Reactions and Brain Apoptosis in a Pathogen-Specific Manner.
    Neonatology 2017 Dec 23;113(3):212-220. Epub 2017 Dec 23.
    Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
    Background: After neonatal asphyxia, therapeutic hypothermia (HT) is the only proven treatment option. Although established as a neuroprotective therapy, benefit from HT has been questioned when infection is a comorbidity to hypoxic-ischaemic (HI) brain injury. Gram-negative and gram-positive species activate the immune system through different pathogen recognition receptors and subsequent immunological systems. Read More

    Postanoxic alpha, theta or alpha-theta coma: Clinical setting and neurological outcome.
    Resuscitation 2017 Dec 22. Epub 2017 Dec 22.
    Department of Clinical Neurophysiology, Marqués de Valdecilla University Hospital, Santander, Cantabria, Spain.
    Aim: The aim of this study was to determine the prognosis of 26 consecutive adults with alpha coma (AC), theta coma (TC) or alpha-theta coma (ATC) following CRA and to describe the clinical setting and EEG features of these patients.

    Methods: We retrospective analyzed a prospectively collected cohort of adult patients diagnosed as having AC, TC or ATC after CRA between January 2008 and June 2016. None of patients included in this analysis underwent therapeutic hypothermia (TH). Read More

    Response to Invited letter to comment on "Impact of spontaneous donor hypothermia on graft outcomes after kidney transplantation".
    Am J Transplant 2017 Dec 21. Epub 2017 Dec 21.
    Vth Department of Medicine, University Medical Center Mannheim, Mannheim, Germany.
    In response to Niemann et al, despite the limitations of the retrospective study design, our data share striking similarities with the intervention trial of therapeutic hypothermia (1). Both, baseline characteristics of the donors and the observed effect on a lessened incidence of delayed graft function (DGF) after transplantation were largely comparable. While the molecular mechanisms remain obscure, it may not be quite clear from the intervention trial to distinguish, whether the quantitative effect on DGF was due to the target cooling temperature or - according to the study protocol - inadvertently amplified by warming of the controls, including 12% of donors who were spontaneously hypothermic (2). Read More

    Implementation of mild therapeutic hypothermia for post-resuscitation care of sudden cardiac arrest survivors in cardiology units in Poland.
    Adv Clin Exp Med 2017 Nov;26(8):1207-1212
    1st Department of Cardiology, Medical University of Warsaw, Poland.
    Background: The post-cardiac arrest (CA) period is often associated with secondary damage of the brain that leads to severe neurological deficits. The current practice guidelines recommend the use of therapeutic hypothermia (TH) to prevent neurological deficit and improve survival.

    Objectives: The aim of the study was to investigate the implementation of medical guidelines in clinical practice and to evaluate the barriers for implementation of TH in cardiology units in Poland. Read More

    Therapeutic hypothermia in patients with coagulopathy following severe traumatic brain injury.
    Scand J Trauma Resusc Emerg Med 2017 Dec 20;25(1):120. Epub 2017 Dec 20.
    Yamaguchi Prefectural Grand Medical Center, 77 Osaki, Boufu, Yamaguchi, 747-8511, Japan.
    Background: Coagulopathy in traumatic brain injury (TBI) has been associated with poor neurological outcomes and higher in-hospital mortality. In general principle of trauma management, hypothermia should be prevented as it directly worsens coagulopathy. Therefore, we examined the safety of mild therapeutic hypothermia (MTH) in patients with coagulopathy following severe TBI. Read More

    Management of Cerebral Edema in Acute Liver Failure.
    Semin Respir Crit Care Med 2017 Dec 20;38(6):821-829. Epub 2017 Dec 20.
    Division of Gastroenterology (Liver Unit), Department of Critical Care Medicine, University of Alberta, Edmonton, Canada.
    Advances in medical care of the acute liver failure patient have led to a significant reduction in mortality related to the condition. Nevertheless, cerebral edema and ensuing brain herniation remains one of the top causes of demise in acute liver failure. Controversy remains regarding the utility of invasive intracranial pressure monitoring as well as usage of novel treatment modalities including therapeutic hypothermia. Read More

    Future Directions for Hypothermia following Severe Traumatic Brian Injury.
    Semin Respir Crit Care Med 2017 Dec 20;38(6):768-774. Epub 2017 Dec 20.
    Department of Neurocritical Care, Neurology, and Emergency Medicine, Oregon Health & Science University, Portland, Oregon.
    Traumatic brain injury (TBI) is a serious health care problem on both individual and public health levels. As a major cause of death and disability in the United States, it is associated with a significant economic and public health burden. Although the evidence to support the use of induced hypothermia on neurologic outcome after cardiac arrest is well established, its use in treating TBI remains controversial. Read More

    Effects of plantar hypothermia on quasi-static balance: Two different hypothermic procedures.
    Gait Posture 2017 Dec 9;60:194-199. Epub 2017 Dec 9.
    Department of Human Locomotion, Institute of Human Movement Science & Health, Chemnitz University of Technology, Germany.
    Inducing hypothermia to examine its effects on balance is performed with various approaches. However, data interpretations of underlying postural mechanisms often do not consider the applied hypothermic protocol. In this context, the effects of diminished plantar mechanoreceptor activity on quasi-static balance performance were investigated, examining the applicability of a continuously cooling thermal platform in comparison with conventional ice pads. Read More

    Association between integrin-linked kinase and hyperthermia in oral squamous cell carcinoma.
    Oncol Lett 2017 Dec 19;14(6):7705-7714. Epub 2017 Oct 19.
    State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
    The present study aimed to observe the effect of the biological functions of integrin-linked kinase (ILK) silencing combined with hyperthermia on Tca8113 cells. Lentivirus-mediated short hairpin RNA (shRNA)-targeting ILK was transfected into oral squamous cell carcinoma (OSCC) Tca8113 cells and, combined with hyperthermia, several experimental methods were used to detect their biological behavior in vitro. On the basis of in vitro experiments, Tca8113 cells were transplanted into nude mice models, and ILK-shRNA-lentivirus was injected into the nude mice transplanted tumor and combined with hyperthermia. Read More

    iTRAQ-Based Quantitative Proteomics Reveals the New Evidence Base for Traumatic Brain Injury Treated with Targeted Temperature Management.
    Neurotherapeutics 2017 Dec 15. Epub 2017 Dec 15.
    Tianjin Key Laboratory of Neurotrauma Repair, Institute of Traumatic Brain Injury and Neuroscience, Center for Neurology and Neurosurgery of Affiliated Hospital, Logistics University of Chinese People's Armed Police Force (PAP), Tianjin, China.
    This study aimed to investigate the effects of targeted temperature management (TTM) modulation on traumatic brain injury (TBI) and the involved mechanisms using quantitative proteomics technology. SH-SY5Y and HT-22 cells were subjected to moderate stretch injury using the cell injury controller (CIC), followed by incubation at TTM (mild hypothermia, 32°C), or normothermia (37°C). The real-time morphological changes, cell cycle phase distribution, death, and cell viability were evaluated. Read More

    Camellia euphlebia exerts its antidepressant-like effect via modulation of the hypothalamic-pituitary-adrenal axis and brain monoaminergic systems.
    Metab Brain Dis 2018 Feb 16;33(1):301-312. Epub 2017 Dec 16.
    School of Life Science and Biotechnology, Dalian University of Technology, Dalian, 116024, China.
    Camellia euphlebia (family, Theaceae) is a Chinese folk medicine, known for its multiple pharmacological properties. The present study aimed to provide further insights into the therapeutic basis of C. euphlebia using several animal behavioral tests and physiological indexes. Read More

    TRPV1-mediated Pharmacological Hypothermia Promotes Improved Functional Recovery Following Ischemic Stroke.
    Sci Rep 2017 Dec 15;7(1):17685. Epub 2017 Dec 15.
    Department of Neurology, McGovern Medical School at UTHealth, Houston, TX, 77030, USA.
    Hypothermia shows promise for stroke neuroprotection, but current cooling strategies cause undesirable side effects that limit their clinical applications. Increasing efforts have focused on pharmacological hypothermia as a treatment option for stroke. Previously, we showed that activation of a thermoregulatory ion channel, transient receptor potential vanilloid 1 (TRPV1), by dihydrocapsaicin (DHC) produces reliable hypothermia. Read More

    Cardiac arrest related to anaesthesia in Williams-Beuren syndrome.
    Rev Esp Anestesiol Reanim 2017 Dec 12. Epub 2017 Dec 12.
    Departamento de Anestesiología Pediátrica, Reanimación y Terapéutica del Dolor, Hospital Universitario La Paz, Madrid, España.
    Williams-Beuren syndrome is the clinical manifestation of a congenital genetic disorder in the elastin gene, among others. There is a history of cardiac arrest refractory to resuscitation manoeuvres in anaesthesia. The incidence of myocardial ischaemia is high during anaesthetic induction, but there are patients who do not have this condition yet also have had very serious cardiac events, and issues that are still to be resolved. Read More

    A Novel Magnetic Resonance Imaging Score Predicts Neurodevelopmental Outcome After Perinatal Asphyxia and Therapeutic Hypothermia.
    J Pediatr 2018 Jan;192:33-40.e2
    Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, The Netherlands. Electronic address:
    Objective: To assess the predictive value of a novel magnetic resonance imaging (MRI) score, which includes diffusion-weighted imaging as well as assessment of the deep grey matter, white matter, and cerebellum, for neurodevelopmental outcome at 2 years and school age among term infants with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia.

    Study Design: This retrospective cohort study (cohort 1, The Netherlands 2008-2014; cohort 2, Sweden 2007-2012) including infants born at >36 weeks of gestational age treated with therapeutic hypothermia who had an MRI in the first weeks of life. The MRI score consisted of 3 subscores: deep grey matter, white matter/cortex, and cerebellum. Read More

    Phase Changing Material for Therapeutic Hypothermia in Neonates with Hypoxic Ischemic Encephalopathy - A Multi-centric Study.
    Indian Pediatr 2017 Dec 14. Epub 2017 Dec 14.
    Department of Neonatology, CMC, Vellore, Tamil Nadu; #Department of Neonatology, JIPMER, Puducherry; $Department of Neonatology, Jubilee Mission Medical College and Research Institute, Thrissur,; Kerala; **Department of Neonatology, St. John's Medical College Hospital, Bengaluru;##The Cradle (by Apollo), Gurgaon; $$Department of Neonatology, KMC, Manipal; ++Sri Ramachandra Medical College Chennai; ***Fernandez Hospital, Hyderabad; ###Neoclinic, Jaipur; $$$Narayana multispeciality hospital, Ahmedabad, Gujarat; and +++Department of Pediatrics, Pramukhswami Medical College, Karamsad, Gujarat; India. Correspondence to: Dr Niranjan Thomasm, Department of Neonatology, Christian Medical College, Vellore 632 004, Tamil Nadu, India.
    Objective: To assess the feasibility and safety of cooling asphyxiated neonates using phase changing material based device across different neonatal intensive care units in India.

    Design: Multi-centric uncontrolled clinical trial.

    Setting: 11 level 3 neonatal units in India from November 2014 to December 2015. Read More

    Endovascular cooling versus standard femoral catheters and intravascular complications: A propensity-matched cohort study.
    Resuscitation 2017 Dec 12;124:1-6. Epub 2017 Dec 12.
    Service de Réanimation médicale, Centre Hospitalier Universitaire de Caen, avenue de la cote de Nacre, 14033 Caen, France; Service de Réanimation Médicale Polyvalente, Centre Hospitalier Public du Cotentin, BP 208, 50102 Cherbourg-en-Cotentin, France.
    Background: Targeted temperature management (TTM) contributes to improved neurological outcome in adults who have been successfully resuscitated after cardiac arrest with shockable rhythm. Endovascular cooling catheters are widely used to induce and maintain targeted temperature in the ICU. The aim of the study was to compare the risk of complications with cooling catheters and standard central venous catheters. Read More

    [Care of the newborn with perinatal asphyxia candidate for therapeutic hypothermia during the first six hours of life in Spain].
    An Pediatr (Barc) 2017 Dec 11. Epub 2017 Dec 11.
    Fundación NeNe, España; Unidad de Neonatología, Hospital Universitario Puerta del Mar, Cádiz, España.
    Introduction: The process of care and assistance from birth to the starting of therapeutic hypothermia (TH) is crucial in order to improve its effectiveness and prevent the worsening of hypoxic-ischaemic injury.

    Methods: A national cross-sectional study carried out in 2015 by use of a questionnaire sent to all level iii units on the care of the newborn≥35 weeks gestation within the first hours of life after a perinatal asphyxia event. According to clinical practice guidelines, the quality of care was compared between the hospitals that carried out or did not carry out TH, and according to the level of care. Read More

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