30,787 results match your criteria Therapeutic Hypothermia


The S100B Protein and Partners in Adipocyte Response to Cold Stress and Adaptive Thermogenesis: Facts, Hypotheses, and Perspectives.

Biomolecules 2020 May 31;10(6). Epub 2020 May 31.

Departament Of Kinesiology and Physical Education and Departament of Neurology and Neurosurgery, McGill University, H3A 2B4 Montreal, QC, Canada.

In mammals, adipose tissue is an active secretory tissue that responds to mild hypothermia and as such is a genuine model to study molecular and cellular adaptive responses to cold-stress. A recent study identified a mammal-specific protein of the endoplasmic reticulum that is strongly induced in the inguinal subcutaneous white adipocyte upon exposure to cold, calsyntenin 3β (CLSTN3β). CLSTN3β regulates sympathetic innervation of thermogenic adipocytes and contributes to adaptive non-shivering thermogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/biom10060843DOI Listing

Gestational poly(I:C) attenuates, not exacerbates, the behavioral, cytokine and mTOR changes caused by isolation rearing in a rat 'dual-hit' model for neurodevelopmental disorders.

Brain Behav Immun 2020 May 30. Epub 2020 May 30.

School of Life Sciences, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK. Electronic address:

Many psychiatric illnesses have a multifactorial etiology involving genetic and environmental risk factors that trigger persistent neurodevelopmental impairments. Several risk factors have been individually replicated in rodents, to understand disease mechanisms and evaluate novel treatments, particularly for poorly-managed negative and cognitive symptoms. However, the complex interplay between various factors remains unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbi.2020.05.076DOI Listing

Neuromuscular blockade management in the critically Ill patient.

J Intensive Care 2020 24;8:37. Epub 2020 May 24.

3Department of Anesthesiology, University of Minnesota Medical School, Minneapolis, MN USA.

Neuromuscular blocking agents (NMBAs) can be an effective modality to address challenges that arise daily in the intensive care unit (ICU). These medications are often used to optimize mechanical ventilation, facilitate endotracheal intubation, stop overt shivering during therapeutic hypothermia following cardiac arrest, and may have a role in the management of life-threatening conditions such as elevated intracranial pressure and status asthmaticus (when deep sedation fails or is not tolerated). However, current NMBA use has decreased during the last decade due to concerns of potential adverse effects such as venous thrombosis, patient awareness during paralysis, development of critical illness myopathy, autonomic interactions, and even residual paralysis following cessation of NMBA use. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40560-020-00455-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245849PMC

Induced Hypothermia to 4.2°C with Neurologically Intact Survival: A Forgotten Case Series.

Wilderness Environ Med 2020 May 29. Epub 2020 May 29.

Department of Anesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Therapy, Armed Forces Hospital Ulm, Ulm, Germany. Electronic address:

The lowest recorded core temperature from which a person with accidental hypothermia has survived neurologically intact is 11.8°C in a 2-y-old boy. The lowest recorded temperature from which an adult has been resuscitated neurologically intact is 13. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wem.2020.02.003DOI Listing

Effects of mild hypothermia on serum HMGB1 of brain-dead donors and its impact on kidney transplantation recipients.

Medicine (Baltimore) 2020 May;99(22):e20425

Department of Urology.

Investigate the effect of mild hypothermia on serum inflammatory factor HMGB1 of brain-dead donors, and its significance for renal transplantation recipients.In our hospital between January 2018 and January 2019 up to the standard of brain death donor (aged 18 to 65 years old) prospective cohort study, brain death donor were randomly divided into mild hypothermia group and the non-mild hypothermia group. Serum were collected from donor at different periods, and enzyme-linked immunoassay (ELISA) was used to determine the serum HMGB1 concentration to compare the difference between the 2 donor groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000020425DOI Listing

A Physiology-Based Pharmacokinetic Framework to Support Drug Development and Dose Precision During Therapeutic Hypothermia in Neonates.

Front Pharmacol 2020 13;11:587. Epub 2020 May 13.

Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

Therapeutic hypothermia (TH) is standard treatment for neonates (≥36 weeks) with perinatal asphyxia (PA) and hypoxic-ischemic encephalopathy. TH reduces mortality and neurodevelopmental disability due to reduced metabolic rate and decreased neuronal apoptosis. Since both hypothermia and PA influence physiology, they are expected to alter pharmacokinetics (PK). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2020.00587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237643PMC

Synergistic Effects of Moderate Therapeutic Hypothermia and Levosimendan on Cardiac Function and Survival After Asphyxia-Induced Cardiac Arrest in Rats.

J Am Heart Assoc 2020 Jun 1:e016139. Epub 2020 Jun 1.

Department of Emergency Medicine National Taiwan University Hospital Taipei Taiwan.

Background This study investigated whether levosimendan, an inotropic calcium sensitizer, when combined with moderate therapeutic hypothermia, may exert synergistic benefits on post-cardiac arrest myocardial dysfunction and improve outcomes. Methods and Results After 9.5-minute asphyxia-induced cardiac arrest and resuscitation, 48 rats were randomized equally into 4 groups following return of spontaneous circulation (ROSC), including normothermia, hypothermia, normothermia-levosimendan, and hypothermia-levosimendan groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/JAHA.120.016139DOI Listing

Safety of Triple Neuroprotection with targeted hypothermia, controlled induced hypertension and barbiturate infusion during emergency carotid endarterectomy for acute stroke after missing the 24 hours window opportunity.

Ann Vasc Surg 2020 May 27. Epub 2020 May 27.

Western Vascular Institute, Department of Vascular and Endovascular Surgery, University Hospital Galway, National University of Ireland, Galway, Ireland;; Galway Clinic, Royal College of Surgeons of Ireland/ National University of Ireland affiliated teaching hospitals, Doughiska, Galway, Ireland.

Background: and Purpose: Our study aims to establish the initial safety of triple neuroprotection (TNP) in an acute stroke setting in patients presenting outside the window for systemic tissue plasminogen activator (tPA).

Methods: Over 12,000 patients were referred to our vascular services with carotid artery disease, of whom, 832 had carotid intervention with a stroke rate of 0.72%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.avsg.2020.05.041DOI Listing

Comparison of neuronal death and expression of TNF‑α and MCT4 in the gerbil hippocampal CA1 region induced by ischemia/reperfusion under hyperthermia to those under normothermia.

Mol Med Rep 2020 May 22. Epub 2020 May 22.

Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan, Chungcheongnam 31116, Republic of Korea.

Monocarboxylate transporter 4 (MCT4) is a high‑capacity lactate transporter in cells and the alteration in MCT4 expression harms cellular survival. The present study investigated whether hypothermia affects tumor necrosis factor‑α (TNF‑α) and MCT4 immunoreactivity in the subfield cornu ammonis 1 (CA1) following cerebral ischemia/reperfusion (IR) in gerbils. Hypothermia was induced for 30 min before and during ischemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/mmr.2020.11182DOI Listing

CDK7 Mediates the Beta-Adrenergic Signaling in Thermogenic Brown and White Adipose Tissues.

iScience 2020 May 15;23(6):101163. Epub 2020 May 15.

Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; Institut National de la Santé et de la Recherche Médicale (Inserm), Languedoc Roussillon, France. Electronic address:

Cyclin-dependent kinases (CDKs) are emerging regulators of adipose tissue metabolism. Here we aimed to explore the role of CDK7 in thermogenic fat. We found that CDK7 brown adipose tissue (BAT)-specific knockout mice (Cdk7) have decreased BAT mass and impaired β3-adrenergic signaling and develop hypothermia upon cold exposure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.isci.2020.101163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256631PMC

Prediction of drug exposure in critically ill encephalopathic neonates treated with therapeutic hypothermia based on a pooled population pharmacokinetic analysis of seven drugs and five metabolites.

Clin Pharmacol Ther 2020 May 28. Epub 2020 May 28.

Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Drug dosing in encephalopathic neonates treated with therapeutic hypothermia is challenging; exposure is dependent on body size and maturation but can also be influenced by factors related to disease and treatment. A better understanding of underlying pharmacokinetic principles is essential to guide drug dosing in this population. The prospective multicenter cohort study PharmaCool was designed to investigate the pharmacokinetics of commonly used drugs in neonatal encephalopathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1917DOI Listing

Sedative and physiological effects of alfaxalone intramuscular administration in cynomolgus monkeys (Macaca fascicularis).

J Vet Med Sci 2020 May 26. Epub 2020 May 26.

Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University.

To evaluate the sedative and physiological effects of alfaxalone intramuscular (IM) administration, 12 healthy cynomolgus monkeys were administered single IM doses of alfaxalone at 0.625 mg/kg (ALFX0.625), 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1292/jvms.20-0043DOI Listing

Hemodynamic Instability in Hypoxic Ischemic Encephalopathy: More Than Just Brain Injury-Understanding Physiology, Assessment, and Management.

Neonatal Netw 2020 May;39(3):129-136

Hypoxic-ischemic encephalopathy (HIE) can have both transient and long-lasting effects on the neonate, including neurologic, renal, cardiac, hepatic, and hematologic. Both the disease process and the treatment option of therapeutic hypothermia can result in hemodynamic instability. Understanding the effects of HIE on the neonatal myocardium, pulmonary vascular bed, and the cardiac dysfunction that can occur is key to managing infants with HIE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1891/0730-0832.39.3.129DOI Listing

Infusion of Cold Saline into the Carotid Artery Does Not Affect Outcome After Intrastriatal Hemorrhage.

Ther Hypothermia Temp Manag 2020 May 22. Epub 2020 May 22.

Department of Psychology, University of Alberta, Edmonton, Canada.

Localized brain hypothermia (HYPO) can be achieved by infusing cold saline into the carotid artery of animals and patients. Studies suggest that HYPO improves behavioral and histological outcomes in focal ischemia models. Given that ischemic stroke and intracerebral hemorrhage (ICH) share pathophysiological overlap, we tested whether cold saline infusion is safe and neuroprotective when given during collagenase-induced ICH. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/ther.2020.0010DOI Listing

Identification of vagus nerve stimulation parameters affecting rat hippocampal electrophysiology without temperature effects.

Brain Stimul 2020 May 23. Epub 2020 May 23.

Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology, Ghent University, 9000, Ghent, Belgium.

Background: Recent experiments in rats have demonstrated significant effects of VNS on hippocampal excitability but were partially attributed to hypothermia, induced by the applied VNS parameters.

Objective: To allow meaningful preclinical research on the mechanisms of VNS and translation of rodent results to clinical VNS trials, we aimed to identify non-hypothermia inducing VNS parameters that significantly affect hippocampal excitability.

Methods: VNS was administered in cycles of 30 seconds including either 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brs.2020.05.011DOI Listing

Functional role for preoptic CB1 receptors in breathing and thermal control.

Neurosci Lett 2020 May 23;732:135021. Epub 2020 May 23.

Department of Animal Morphology and Physiology, Sao Paulo State University, UNESP/FCAV at Jaboticabal, SP, Brazil. Electronic address:

The anteroventral preoptic region (AVPO) of the hypothalamus is involved in both temperature and breathing regulation. This area densely express cannabinoid receptors type 1 (CB1) that modulate both excitatory and inhibitory synaptic transmission. However, it is still unknown if the endocannabinoid system located in the AVPO participates in breathing control and thermoregulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2020.135021DOI Listing

Dual benefit of combined neuroprotection: Cholesterol depletion restores membrane microviscosity but not lipid order and enhances neuroprotective action of hypothermia in rat cortex nerve terminals.

Biochim Biophys Acta Biomembr 2020 May 21;1862(9):183362. Epub 2020 May 21.

Dep. of Neurochemistry of the Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 9 Leontovicha Str., Kyiv 01054, Ukraine.

Here, both neuroprotectants, i.e. cholesterol depletion of the plasma membrane of rat brain nerve terminals (synaptosomes) using methyl-β-cyclodextrin (MβCD) and deep/propound hypothermia, were analyzed during their combined administration and regarding additive neuroprotective effect. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamem.2020.183362DOI Listing

An overview of management of intracranial hypertension in the intensive care unit.

J Anesth 2020 May 21. Epub 2020 May 21.

2nd Department of Intensive Care Medicine, George Papanikolaou General Hospital, G. Papanikolaou Avenue, 57010, Exochi, Thessaloniki, Greece.

Intracranial hypertension (IH) is a clinical condition commonly encountered in the intensive care unit, which requires immediate treatment. The maintenance of normal intracranial pressure (ICP) and cerebral perfusion pressure in order to prevent secondary brain injury (SBI) is the central focus of management. SBI can be detected through clinical examination and invasive and non-invasive ICP monitoring. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00540-020-02795-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241587PMC

Goal-directed cerebral perfusion in aortic arch surgery: scientific leap or hype?

Asian Cardiovasc Thorac Ann 2020 May 21:218492320929212. Epub 2020 May 21.

Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, USA.

Although significant advancements in cerebral protection strategies in aortic surgery have been achieved in recent years, controversy remains on what constitutes the optimal strategy. Deep hypothermic circulatory arrest alone is a viable approach in many instances, but the need for a prolonged duration of circulatory arrest and increasing case complexity have led to the utilization of adjunctive cerebral perfusion strategies. In this review, we discuss the efficacy of deep hypothermic circulatory arrest and its limitations, the role of retrograde cerebral perfusion and unilateral and bilateral antegrade cerebral perfusion, and the trend towards goal-directed perfusion strategies, all emphasizing the pressing need for randomized clinical trials to better define the optimal strategy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0218492320929212DOI Listing

Neuroprotective Effects of Diabetes Drugs for the Treatment of Neonatal Hypoxia-Ischemia Encephalopathy.

Front Cell Neurosci 2020 6;14:112. Epub 2020 May 6.

UCL School of Pharmacy, University College London, London, United Kingdom.

The perinatal period represents a time of great vulnerability for the developing brain. A variety of injuries can result in death or devastating injury causing profound neurocognitive deficits. Hypoxic-ischemic neonatal encephalopathy (HIE) remains the leading cause of brain injury in term infants during the perinatal period with limited options available to aid in recovery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fncel.2020.00112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218053PMC

Effects of Different Target Temperatures on Angiogenesis and Neurogenesis Following Resuscitation in a Porcine Model After Cardiac Arrest.

Shock 2020 May 18. Epub 2020 May 18.

Department of Emergency Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.

Objective: The optimal effective temperature of targeted temperature management (TTM) used to prevent cerebral injury following cardiopulmonary resuscitation (CPR) is undetermined. In this study, we compared the mortality, neurologic deficits, and cerebral protein levels of two target temperatures.

Methods: Fifty 4-month-old female domestic pigs were randomised to sham, TTM at 33°C ± 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SHK.0000000000001559DOI Listing

Therapeutic strategies for ischemia reperfusion injury in emergency medicine.

Acute Med Surg 2020 Jan-Dec;7(1):e501. Epub 2020 Apr 13.

Department of Emergency, Critical Care and Disaster Medicine Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan.

Ischemia reperfusion (IR) injury occurs when blood supply, perfusion, and concomitant reoxygenation is restored to an organ or area following an initial poor blood supply after a critical time period. Ischemia reperfusion injury contributes to mortality and morbidity in many pathological conditions in emergency medicine clinical practice, including trauma, ischemic stroke, myocardial infarction, and post-cardiac arrest syndrome. The process of IR is multifactorial, and its pathogenesis involves several mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ams2.501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231568PMC

A breeding strategy to identify modifiers of high genetic risk for methamphetamine intake.

Genes Brain Behav 2020 May 18:e12667. Epub 2020 May 18.

Department of Behavioral Neuroscience and Methamphetamine Abuse Research Center, Oregon Health & Science University, Portland, Oregon, USA.

Trace amine-associated receptor 1 (Taar1) impacts methamphetamine (MA) intake. A mutant allele (Taar1 ) derived from the DBA/2 J mouse strain codes for a non-functional receptor, and Taar1 mice consume more MA than mice possessing the reference Taar1 allele. To study the impact of this mutation in a genetically diverse population, heterogeneous stock-collaborative cross (HS-CC) mice, the product of an 8-way cross of standard and wild-derived strains, were tested for MA intake. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/gbb.12667DOI Listing

Intra-arterial neuroprotective therapy as an adjunct to endovascular intervention in acute ischemic stroke: A review of the literature and future directions.

Interv Neuroradiol 2020 May 19:1591019920925677. Epub 2020 May 19.

Department of Neurology, Weill Cornell Medical Institution New York Presbyterian Hospital, New York, NY, USA.

Mechanical thrombectomy for acute ischemic stroke due to large vessel occlusion has been shown to significantly improve outcomes. However, despite efficient rates of recanalization (60-90%), the rates of functional independence remain suboptimal (14-58%), most likely due to pathways of cell death in the brain that have already committed despite successful reperfusion. Pharmacologic neuroprotection provides a potential means of preventing this inevitable damage through targeting excitotoxicity, reactive oxygen species, cellular apoptosis, and inflammation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1591019920925677DOI Listing

Early exit from neonatal therapeutic hypothermia: A single institution experience using mri to guide decision-making.

J Neonatal Perinatal Med 2020 May 13. Epub 2020 May 13.

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Background: To evaluate the feasibility of a protocol using combined magnetic resonance imaging (MRI), clinical data, and electroencephalogram (EEG) to identify neonates with mild neonatal encephalopathy (NE) treated with therapeutic hypothermia (TH) who are eligible for "early exit".

Methods: Retrospective chart review of TH cases at a single Level III NICU over a 5-year period was used to describe the demographic, clinical, and outcome data in neonates that received early exit in contrast to 72 hour TH treatment.

Results: Two hundred and eight TH cases, including 18 early exit cases (9%) and 9 cases (4%) evaluated for early exit with MRI but continued on 72 hours of TH, were identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/NPM-200458DOI Listing

Effect of Peripheral Insulin Administration on Phosphorylation of Tau in the Brain.

J Alzheimers Dis 2020 May 13. Epub 2020 May 13.

Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.

Background: Abnormally hyperphosphorylated tau is the major protein of neurofibrillary tangles in Alzheimer's disease. Insulin activates PI3K-AKT signaling and regulates tau phosphorylation. Impaired brain insulin signaling is involved in Alzheimer's disease pathogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-200147DOI Listing

Neuronal Biomarkers in Predicting Neurodevelopmental Outcome in Term Babies with Perinatal Asphyxia.

Indian J Pediatr 2020 May 16. Epub 2020 May 16.

Department of Preventive & Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

Objective: To assess whether serum levels of neuronal biomarkers (S100 calcium-binding protein B and Neuron specific enolase) correlate with the neurodevelopmental outcome of term neonates at 18 mo who had hypoxic ischemic encephalopathy and underwent therapeutic hypothermia.

Methods: This randomized controlled trial was conducted in a tertiary care teaching hospital, south India. There were 162 term infants with moderate to severe hypoxic ischemic encephalopathy who were randomized into 2 groups (Group A and B). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12098-020-03283-2DOI Listing

Effects of local hypothermia-rewarming on physiology, metabolism and inflammation of acutely injured human spinal cord.

Sci Rep 2020 May 15;10(1):8125. Epub 2020 May 15.

Academic Neurosurgery Unit, Molecular and Clinical Sciences Institute, St. George's, University of London, London, UK.

In five patients with acute, severe thoracic traumatic spinal cord injuries (TSCIs), American spinal injuries association Impairment Scale (AIS) grades A-C, we induced cord hypothermia (33 °C) then rewarming (37 °C). A pressure probe and a microdialysis catheter were placed intradurally at the injury site to monitor intraspinal pressure (ISP), spinal cord perfusion pressure (SCPP), tissue metabolism and inflammation. Cord hypothermia-rewarming, applied to awake patients, did not cause discomfort or neurological deterioration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-64944-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229228PMC
May 2020
5.078 Impact Factor

Hypothermia as an adjuvant treatment in paediatric refractory or super-refractory status epilepticus.

Authors:
Stephane Legriel

Dev Med Child Neurol 2020 May 15. Epub 2020 May 15.

Medico-Surgical Intensive Care Department, Centre Hospitalier de Versailles, Le Chesnay, France.

Therapeutic hypothermia is among the adjuvant therapies suggested for refractory or super-refractory status epilepticus (R/SR-SE) in paediatric patients. Experimental evidence of neuroprotective and antiseizure effects provides a strong rationale for using therapeutic hypothermia in patients with status epilepticus. Thus, hypothermia between 20°C and 33°C in animals with status epilepticus is associated not only with significantly less neuronal damage, predominantly in the hippocampal CA1, CA2, and CA3 areas, but also with increased seizure latency and decreased seizure frequency and duration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dmcn.14562DOI Listing

Multidisciplinary management and outcome in pancreatic cancer patients treated with high-intensity focused ultrasound.

Int J Hyperthermia 2020 ;37(1):456-462

Clinic for Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany.

High-intensity focused ultrasound (HIFU) for pancreatic cancer is a growing therapeutic field which has been proven to reduce cancer pain and provide a local tumor control additionally to standard palliative care. However, less is known about the multidisciplinary and especially anesthesiological management of HIFU treatment although an interdisciplinary approach is crucial for treatment success. Anesthesiological and radiological records of 71 HIFU-treated pancreatic cancer patients were analyzed with regard to the following items: intervention time, sonication time, total energy, anesthesia time, peri-interventional medication, body temperature maximum and minimum, pain scores before and 1 day, 6 weeks and 3 months after intervention, peri-interventional complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/02656736.2020.1762006DOI Listing
January 2020

A systematic review and meta-analysis of hypothermia in experimental traumatic brain injury: why have promising animal studies not been replicated in pragmatic clinical trials?

J Neurotrauma 2020 May 12. Epub 2020 May 12.

The University of Edinburgh Centre for Clinical Brain Sciences, 439257, Edinburgh, Edinburgh, United Kingdom of Great Britain and Northern Ireland;

Therapeutic hypothermia was a mainstay of severe traumatic brain injury (TBI) management for half a century. Recent trials have suggested that its effect on long term functional outcome is neutral or negative, despite apparently promising preclinical data. Systematic review and meta-analysis is a useful tool to collate experimental data and investigate the basis of its conclusions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/neu.2019.6923DOI Listing

Minimal Invasive Pericardial Perfusion Model in Swine: A Translational Model for Cardiac Remodeling After Ischemia/Reperfusion Injury.

Front Physiol 2020 22;11:346. Epub 2020 Apr 22.

Cedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, United States.

Rationale: Adverse remodeling leads to heart failure after myocardial infarction (MI), with important impact on morbidity and mortality. New therapeutic approaches are needed to further improve and broaden heart failure therapy. We established a minimally invasive, reproducible pericardial irrigation model in swine, as a translational model to study the impact of temperature on adverse cardiac remodeling and its molecular mechanisms after MI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphys.2020.00346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188781PMC

Variability in deceased donor care in Canada: a report of the Canada-DONATE cohort study.

Can J Anaesth 2020 May 8. Epub 2020 May 8.

Department of Medicine, McMaster University, Hamilton, ON, Canada.

Purpose: Canadian donor management practices have not been reported. Our aim was to inform clinicians and other stakeholders about the range of current practices.

Methods: This prospective observational cohort study enrolled consecutive, newly consented organ donors from August 1 2015 to July 31 2018 at 27 academic and five community adult intensive care units in British Columbia, Alberta, Ontario, and Quebec. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12630-020-01692-7DOI Listing

VGLUT2-expressing neurons in the vestibular nuclear complex mediate gravitational stress-induced hypothermia in mice.

Commun Biol 2020 May 8;3(1):227. Epub 2020 May 8.

Department of Physiology, Gifu University Graduate School of Medicine, Gifu, Japan.

The vestibular system, which is essential for maintaining balance, contributes to the sympathetic response. Although this response is involved in hypergravity load-induced hypothermia in mice, the underlying mechanism remains unknown. This study showed that hypergravity (2g) decreased plasma catecholamines, which resulted in hypoactivity of the interscapular brown adipose tissue (iBAT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s42003-020-0950-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210111PMC

Hypothermia Attenuates Neuronal Damage via Inhibition of Microglial Activation, Including Suppression of Microglial Cytokine Production and Phagocytosis.

Cell Mol Neurobiol 2020 May 7. Epub 2020 May 7.

Department of Pathobiology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Mizohoku Tanabedori, Nagoya, Aichi, 467-8603, Japan.

Although therapeutic hypothermia (TH) provides neuroprotection, the cellular mechanism underlying the neuroprotective effect of TH has not yet been fully elucidated. In the present study, we investigated the effect of TH on microglial activation to determine whether hypothermia attenuates neuronal damage via microglial activation. After lipopolysaccharide (LPS) stimulation, BV-2 microglia cells were cultured under normothermic (37 °C) or hypothermic (33. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10571-020-00860-zDOI Listing

Antiplasmodial Activity of Different Solvent Extracts of Stem Bark and Its Constituents in -Infected Mice.

Evid Based Complement Alternat Med 2020 21;2020:8703197. Epub 2020 Apr 21.

Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

The emergence and resurgence of resistance to generations of antimalarial drugs have prompted the search for new, effective, and safe antimalarial agents. This study aimed at investigating the antiplasmodial activity of the 70% hydroethanolic extract and constituents of the stem bark of based on its ethnomedicinal use as an antimalarial agent. The antiplasmodial activity was assessed in Swiss albino mice employing the 4-day suppressive and Rane's tests. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/8703197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191442PMC

Therapeutic Hypothermia in Acute Ischemic Stroke-a Systematic Review and Meta-Analysis.

Curr Neurol Neurosci Rep 2020 May 5;20(5):13. Epub 2020 May 5.

Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Purpose Of Review: Therapeutic hypothermia (TH) in stroke demonstrates robust neuroprotection in animals but clinical applications remain controversial. We assessed current literature on the efficacy of TH in ischemic stroke.

Recent Findings: We conducted a meta-analysis comparing TH versus controls in studies published until June 2019. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11910-020-01029-3DOI Listing

Cerebral blood flow velocity and oxygenation correlate predominantly with right ventricular function in cooled neonates with moderate-severe hypoxic-ischemic encephalopathy.

Eur J Pediatr 2020 May 4. Epub 2020 May 4.

Division of Neonatology, Insituto del Niño y del Adolescente. Hospital Clinico San Carlos -IdISSC, Prof. Martin Lagos s/n, 28040, Madrid, Spain.

The relationship between right ventricular (RV) function and cerebral blood flow (CBF) velocity and cerebral oxygenation was assessed in neonates with hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH). Echocardiographic, transcranial Doppler, and hemodynamic data from 37 neonates with moderate-severe HIE + TH were reviewed. Twenty healthy newborns served as controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00431-020-03657-wDOI Listing

Biomarkers in newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia.

Childs Nerv Syst 2020 May 4. Epub 2020 May 4.

Department of Neonatology, Poznan University of Medical Sciences, Poznan, Poland.

Purpose: The aim of the presented study was to evaluate the differences between selected biochemical markers in infants with moderate or severe hypoxic-ischemic encephalopathy (HIE) and their impact on patient prognosis.

Methods: A total of 57 cooled newborns were divided into groups according to Sarnat staging of HIE (A, moderate vs. B, severe). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00381-020-04645-zDOI Listing

Control of brown adipose tissue adaptation to nutrient stress by the activin receptor ALK7.

Elife 2020 May 5;9. Epub 2020 May 5.

Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.

Adaptation to nutrient availability is crucial for survival. Upon nutritional stress, such as during prolonged fasting or cold exposure, organisms need to balance the feeding of tissues and the maintenance of body temperature. The mechanisms that regulate the adaptation of brown adipose tissue (BAT), a key organ for non-shivering thermogenesis, to variations in nutritional state are not known. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.54721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200161PMC

Impact of Erythropoietin in the management of Hypoxic Ischaemic Encephalopathy in resource-constrained settings: protocol for a randomized control trial.

BMC Neurol 2020 May 4;20(1):171. Epub 2020 May 4.

Division of Epidemiology and Biostatistics, School of Public Health, University of Witwatersrand, Johannesburg, South Africa.

Background: Perinatal asphyxia, more appropriately known as hypoxic-ischemic encephalopathy (HIE), is a condition characterized by clinical and laboratory evidence of acute or sub-acute brain injury resulting from systemic hypoxemia and/or reduced cerebral blood flow. HIE is a common and devastating clinical condition in resource-poor countries with poor treatment outcome. This paper describes the protocol for an ongoing study that aims to evaluate the neuroprotective effects of Erythropoietin (EPO) as compared to routine care in the management of moderate to severe HIE among term infants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12883-020-01751-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199320PMC

An Exploratory Report on Electrographic Changes in the Cerebral Cortex Following Mild Traumatic Brain Injury with Hyperthermia in the Rat.

Ther Hypothermia Temp Manag 2020 May 5. Epub 2020 May 5.

The Miami Project to Cure Paralysis, Miller School of Medicine, University of Miami, Miami, Florida, USA.

Traumatic brain injury (TBI) has the potential to perturb perception by disrupting electrical propagation within and between the thalamus and cerebral cortex. Moderate and severe TBI may result in posttraumatic epilepsy, a condition characterized by convulsive tonic-clonic seizures. Spike/wave discharges (SWDs) of generalized nonconvulsive seizures, also called absence seizures, may also occur as a consequence of brain trauma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/ther.2020.0002DOI Listing

Prior viral illness increases heat stroke severity in mice.

Exp Physiol 2020 May 2. Epub 2020 May 2.

US Army Research Institute of Environmental Medicine, Thermal Mountain Medicine Division, Natick, MA, USA.

New Findings: What is the central question of this study? We hypothesized that prior illness would increase the susceptibility to and severity of heat stroke (HS). What is the main finding and its importance? We provide the first experimental evidence, using a mouse model of HS, that recent viral illness increases the severity of HS. Our data indicate that this effect is not attributable to the exacerbation of hyperthermia but is a consequence of ongoing coagulation and systemic inflammatory reactions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1113/EP088480DOI Listing

The investigation of the potential antidepressant-like activity of Xanthium orientale subsp. italicum (Moretti) Greuter in rodents.

J Ethnopharmacol 2020 Aug 28;258:112914. Epub 2020 Apr 28.

Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler, 06330, Ankara, Turkey. Electronic address:

Ethnopharmacological Relevance: Ethnobotanical surveys revealed that Xanthiumorientale subsp. italicum (Moretti) Greuter has been used against central nervous system disorders in Turkish folk medicine. The aim of the present study is to verify the folkloric assertion on this plant. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2020.112914DOI Listing

Prolonged astrocyte-derived erythropoietin expression attenuates neuronal damage under hypothermic conditions.

J Neuroinflammation 2020 May 2;17(1):141. Epub 2020 May 2.

Department of Pathobiology, Nagoya City University Graduate School of Pharmaceutical Sciences, 3-1 Tanabedori, Mizoho-ku, Nagoya, Aichi, 467-8603, Japan.

Background: Hypoxic-ischemic encephalopathy (HIE) has a high morbidity rate and involves severe neurologic deficits, including cerebral palsy. Therapeutic hypothermia (TH) has been shown to decrease the mortality rate and provide neuroprotection in infants with HIE. However, death and disability rates in HIE infants treated with TH remain high. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12974-020-01831-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195727PMC

Methiopropamine and its acute behavioral effects in mice: is there a gray zone in new psychoactive substances users?

Int J Legal Med 2020 May 1. Epub 2020 May 1.

Department of Morphology, Surgery and Experimental Medicine, Section of Legal Medicine and LTTA Centre, University of Ferrara, via Fossato di Mortara 70, 44121, Ferrara, Italy.

Methiopropamine is a structural analog of methamphetamine that is categorized as a novel psychoactive substance. It primarily acts as a norepinephrine-dopamine reuptake inhibitor and, secondarily, as a serotonin reuptake inhibitor. In humans, methiopropamine induces stimulation and alertness and increases focus and energy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00414-020-02302-3DOI Listing

Therapeutic Hypothermia in Critically Ill Patients: A Systematic Review and Meta-Analysis of High Quality Randomized Trials.

Crit Care Med 2020 Apr 30. Epub 2020 Apr 30.

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Objectives: To investigate the effect of the application of therapeutic hypothermia (32-35°C) on survival and major clinical endpoints in critically ill patients.

Data Sources: We searched online database and clinical trial registries dated up to April 30, 2019, and references of relevant studies.

Study Selection: Low risk of bias randomized trials which compared hypothermia applied for at least 24 hours and conventional therapy in critically ill patients were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000004364DOI Listing

Cervical spinal cord injury by a low-impact trauma as an unnoticed cause of cardiorespiratory arrest.

Eur Heart J Case Rep 2020 Apr 10;4(2):1-6. Epub 2020 Mar 10.

Neurology Department, Hospital Clínic de Barcelona, Centros de Investigación Biomédica en Red de enfermedades neurodegenerativas (CIBERNED), C/Villarroel 170, Barcelona 0008036, Spain.

Background: Cardiorespiratory arrest (CA) secondary to traumatic cervical spinal cord injury can occur in minor accidents with low-impact trauma and may be overlooked as the cause of CA in patients admitted in the coronary care unit.

Case Summary: We present two patients admitted to the coronary care unit because of suspected CA of cardiac origin. Both patients were found in CA with asystole, one after collapsing in a shopping mall and falling down a few steps and the other in the street next to his bicycle. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ehjcr/ytaa044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180526PMC

Precision and Safety of an Intravascular Temperature Management System for Postcardiac Arrest Syndrome Patients: A Multicenter Clinical Trial (COOL-ARREST JP).

Ther Hypothermia Temp Manag 2020 Apr 28. Epub 2020 Apr 28.

Advanced Emergency and Critical Care Center, Iwate Medical University Hospital, Morioka, Japan.

Rapid induction and maintaining a target temperature of 32.0-36.0°C within a narrow range for <24 hours are essential, but those are very hard to perform in postcardiac arrest syndrome (PCAS) patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/ther.2019.0046DOI Listing