32,522 results match your criteria Therapeutic Hypothermia


Deletion of Drives the Activation of Mitochondrial Uncoupling Respiration to Induce Adipose Thermogenesis in Female Mice.

Front Endocrinol (Lausanne) 2022 3;13:877152. Epub 2022 May 3.

Department of Human Nutrition, Foods and Exercise, College of Agricultural and Life Sciences, Virginia Tech, Blacksburg, VA, United States.

Thermogenic adipocytes possess a promising approach to combat obesity with its capability promoting energy metabolism. We previously discovered that deletion of (GPRKO), a presumably membrane-associated estrogen receptor, protected female mice from developing obesity, glucose intolerance, and insulin resistance when challenged with a high-fat diet (HFD). , the metabolic phenotype of wild type (WT) and GPRKO female mice were measured weekly. Read More

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A red flag for diagnosing brain death: decompressive craniectomy of the posterior fossa.

Can J Anaesth 2022 May 18. Epub 2022 May 18.

Department of Anesthesiology and Intensive Care Medicine, Rostock University Medical Center, Rostock, Germany.

Purpose: Brain death/death by neurologic criteria (BD/DNC) may be determined in many countries by a clinical examination that shows coma, brainstem areflexia, and apnea, provided the conditions causing reversible loss of brain function are excluded a priori. To date, accounts of recovery from BD/DNC in adults have been limited to noncompliance with guidelines.

Clinical Features: We report the case of a 72-yr-old man with a combined primary infratentorial (hemorrhagic) and secondary global (anoxic) brain lesion in whom decompressive craniectomy of the posterior fossa and six-hour therapeutic hypothermia (33-34°C) followed by 8-hour rewarming to ≥ 36°C were conducted. Read More

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Lessons of the month 2: Olanzapine-induced hypothermia and hand oedema.

Clin Med (Lond) 2022 May;22(3):285-286

St Vincent De Paul Long-Term Care Facility, Luqa, Malta.

Introduction: We describe a case of olanzapine-induced hypothermia and hand oedema in an older adult with behavioural and psychological symptoms of dementia (BPSD).

Case Presentation: An 82-year-old woman with hypothyroidism and dementia was reviewed by the geriatric team at a nursing home in view of lethargy and an unrecordable oral temperature. She was noted to have a bilateral hand oedema and right basal crackles. Read More

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Imaging of Potassium and Calcium Distribution in Plant Tissues and Cells to Monitor Stress Response and Programmed Cell Death.

Methods Mol Biol 2022 ;2447:233-246

Department of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.

In plants, the response to stress, such as salinity, pathogen attack, drought, high concentration of metals, hyperthermia, and hypothermia, is usually accompanied by potassium ion (K) leakage from the cytosol to the cell wall, mediated by plasma membrane cation conductivity. Stress-induced electrolyte leakage co-occurs with accumulation of reactive oxygen species (ROS) and calcium ions (Ca) and often results in programmed cell death (PCD). The development of X-ray and mass spectrometry (MS) based imaging techniques has enabled insight into the spatial tissue and cell-specific redistribution of major and trace elements during the stress response. Read More

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Serum neuron-specific enolase, magnetic resonance imaging, and electrophysiology for predicting neurodevelopmental outcomes of neonates with hypoxic-ischemic encephalopathy: a prospective study.

BMC Pediatr 2022 May 17;22(1):290. Epub 2022 May 17.

Department of Pediatrics, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Background: Neonatal hypoxic-ischemic encephalopathy (HIE) is an important cause of mortality and morbidity. Effective indicators for the early diagnosis of brain injury after HIE and prognosis are lacking. This study aimed to examine the predictive value of serum neuron-specific enolase (NSE), amplitude-integrated electroencephalography (aEEG), and magnetic resonance imaging (MRI), alone and in combination, for the neurological outcomes in neonates with HIE. Read More

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Antipsychotic-Induced Hypothermia After Starting Aripiprazole for Posttraumatic Agitation Management: A Case Report.

Clin Neuropharmacol 2022 May-Jun 01;45(3):74-77. Epub 2022 Apr 14.

Department of Physical Medicine and Rehabilitation, Rutgers-New Jersey Medical School, Newark, NJ.

Objectives: Antipsychotic-induced hypothermia is an uncommon type of secondary hypothermia resulting from neurotransmitter derangements within the nervous system thermoregulation pathway. The most common causative medications include olanzapine, haloperidol, and risperidone, with one published report of aripiprazole. Most individuals who develop antipsychotic-induced hypothermia receive neuroleptic treatment for psychiatric disorder management, with significantly fewer occurrences in those with neurologic disorders. Read More

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Association between multi-organ dysfunction and adverse outcome in infants with hypoxic ischemic encephalopathy.

J Perinatol 2022 May 16. Epub 2022 May 16.

Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Stanford, CA, USA.

Objective: To evaluate multi-organ dysfunction (MOD) in newborns treated with therapeutic hypothermia (TH) for hypoxic ischemic encephalopathy (HIE), and to compare MOD in those with normal/mild magnetic resonance imaging (MRI) findings to those with moderate to severe MRI findings or death.

Study Design: Retrospective single-center observational study of infants treated with TH. A total of 16 parameters across 7 organ systems were analyzed. Read More

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Association of Maternal Obesity and Neonatal Hypoxic-Ischemic Encephalopathy.

Front Pediatr 2022 29;10:850654. Epub 2022 Apr 29.

Department of Pediatrics, Bernard and Millie Duker Children's Hospital at Albany Medical Center, Albany, NY, United States.

Objective: More women are obese at their first prenatal visit and then subsequently gain further weight throughout pregnancy than ever before. The impact on the infant's development of neonatal hypoxic ischemic encephalopathy (HIE) has not been well studied. Using defined physiologic and neurologic criteria, our primary aim was to determine if maternal obesity conferred an additional risk of HIE. Read More

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Bispectral index and suppression ratio after cardiac arrest: are they useful as bedside tools for rational treatment escalation plans?

Rev Esp Cardiol (Engl Ed) 2022 May 12. Epub 2022 May 12.

Unidad de Cuidados Agudos Cardiovasculares, Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain; Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Madrid, Spain.

Introduction And Objectives: Myocardial dysfunction contributes to early mortality (24-72 hours) among survivors of a cardiac arrest (CA). The benefits of mechanical support in refractory shock should be balanced against the patient's potential for neurological recovery. To date, these early treatment decisions have been taken based on limited information leading mainly to undertreatment. Read More

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Distinct post-sepsis induced neurochemical alterations in two mouse strains.

Brain Behav Immun 2022 May 13;104:39-53. Epub 2022 May 13.

APC Microbiome Ireland, University College Cork, Ireland; Neuropharmacology Research Group, Department of Pharmacology & Therapeutics, University College Cork, Ireland; Department of Anatomy & Neuroscience, University College Cork, Ireland.

Sepsis associated encephalopathy, occurs in 70% of severe septic cases, following which survivors exhibit long-term cognitive impairment or global loss of cognitive function. Currently there is no clearly defined neurochemical basis of septic encephalopathy. Moreover, the lingering neurological complications associated with the severe acute respiratory syndrome CoV 2 (SARS-CoV-2) and the significant worsening in outcomes for those individuals with SARS-Cov-2 following sepsis underscore the need to define factors underlying the susceptibility to acute toxic encephalitis. Read More

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Three-year outcome following neonatal encephalopathy in a high-survival cohort.

Sci Rep 2022 May 13;12(1):7945. Epub 2022 May 13.

Center for Human Development and Family Science, Department of Neonatology and Pediatrics, Nagoya City University Graduate School of Medical Sciences, Aichi, Nagoya, 467-8601, Japan.

This study investigated the 3-year clinical outcomes in relation to the severity of encephalopathy in high-survival infants who underwent therapeutic hypothermia. This retrospective observational study was conducted in level II/III neonatal intensive care units in Japan. The nationwide cohort included 474 infants registered in the Baby Cooling Registry of Japan between January 2012 and December 2016. Read More

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Dexmedetomidine Versus Fentanyl for Neonates With Hypoxic Ischemic Encephalopathy Undergoing Therapeutic Hypothermia.

J Pediatr Pharmacol Ther 2022 9;27(4):352-357. Epub 2022 May 9.

Department of Pharmacy, University of Chicago Medicine Comer Children's Hospital, Chicago, IL.

Objective: Therapeutic hypothermia reduces the risk of death and major disability in neonates with moderate-to-severe hypoxic ischemic encephalopathy (HIE). Opioids and benzodiazepines are used to manage agitation but contribute to hemodynamic and respiratory instability. The objective of this study was to evaluate the safety and efficacy of dexmedetomidine (DEX) compared with fentanyl (FENT) in neonates with HIE undergoing therapeutic hypothermia. Read More

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Variations in practices and outcomes of neonates with hypoxic ischemic encephalopathy treated with therapeutic hypothermia across tertiary NICUs in Canada.

J Perinatol 2022 May 12. Epub 2022 May 12.

Department of Paediatrics, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada.

Objective: To characterize variations in practices and outcomes for neonates with hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH) across Canadian tertiary Neonatal Intensive Care Units (NICUs).

Study Design: Retrospective study of neonates admitted for HIE and treated with TH in 24 tertiary NICUs from the Canadian Neonatal Network, 2010-2020. The two primary outcomes of mortality before discharge and MRI-detected brain injury were compared across NICUs using adjusted standardized ratios (SR) with 95% CI. Read More

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Increase of Parkin and ATG5 plasmatic levels following perinatal hypoxic-ischemic encephalopathy.

Sci Rep 2022 May 12;12(1):7795. Epub 2022 May 12.

Department of Medical Sciences, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Via Fossato di Mortara 70, 44121, Ferrara, Italy.

Brain injury at birth is an important cause of neurological and behavioral disorders. Hypoxic-ischemic encephalopathy (HIE) is a critical cerebral event occurring acutely or chronically at birth with high mortality and morbidity in newborns. Therapeutic strategies for the prevention of brain damage are still unknown, and the only medical intervention for newborns with moderate-to-severe HIE is therapeutic hypothermia (TH). Read More

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A Rare Case of Risperidone-Induced Hypothermia and Thrombocytopenia.

Cureus 2022 May 9;14(5):e24836. Epub 2022 May 9.

Hospital Medicine, CHRISTUS Spohn Hospital Corpus Christi - Shoreline, Corpus Christi, USA.

Psychosis is a term defined in medical literature broadly as someone who has lost contact with reality. Psychosis is typically seen in multiple psychiatric disorders, for example, schizophrenia, bipolar disorder, and severe depression. It is also seen in patients abusing drugs and other underlying medical conditions like hepatic impairment, renal failure, etc. Read More

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The Complex Relationship Between Cooling Parameters and Neuroprotection in a Model of Selective Hypothermia.

Front Neurol 2022 25;13:874701. Epub 2022 Apr 25.

Division of Neurosurgery, Halifax Infirmary, Halifax, NS, Canada.

Background: Hypothermia remains the best studied neuroprotectant. Despite extensive positive large and small animal data, side effects continue to limit human applications. Selective hypothermia is an efficient way of applying neuroprotection to the brain without the systemic complications of global hypothermia. Read More

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Inter-observer reliability for amplitude-integrated electroencephalography in the newborn with perinatal asphyxia.

An Pediatr (Engl Ed) 2022 May 6. Epub 2022 May 6.

Unidad de Neonatología, Complejo Asistencial Universitario de Burgos, Burgos, Spain; Fundación NeNe, Spain. Electronic address:

Introduction: Amplitude integrated electroencephalography (aEEG) is a tool widely used for neuromonitoring in the critical neonate. In the patient with perinatal asphyxia, its interpretation is key to identifying candidates for therapeutic hypothermia, detecting subclinical seizures and providing pronostic information. Our aim was to analyze the concordance in the interpretation of aEEG among neonatologists with different levels of experience. Read More

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Chemotherapy, Alopecia, and Scalp Cooling Systems.

Actas Dermosifiliogr 2022 Mar 12;113(3):278-283. Epub 2021 Oct 12.

Servicio de Oncología Clínica, Hospital de Clínicas, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.

Chemotherapy-induced hair loss in cancer is usually temporary but can take a significant emotional toll on patients and lead to treatment refusal in many cases. Although hair loss is usually reversible, regrowth can take months, causing greater psychological distress. Recent years have seen the emergence of cold caps, or scalp cooling systems, designed to prevent or at least reduce chemotherapy-induced hair loss. Read More

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Association of time-temperature curves with outcomes in temperature management for cardiac arrest.

BMJ Neurol Open 2022 18;4(1):e000273. Epub 2022 Apr 18.

Department of Neurology, Duke University School of Medicine, Durham, North Carolina, USA.

Background/purpose: Cardiac arrest is a common cause of death and neurological injury; therapeutic cooling for neuroprotection is standard of care. Despite numerous and ongoing trials targeting a specified cooling temperature for a target duration, the concept of temperature dose-the duration spent at a given depth of hypothermia-is not as well explored.

Methods: In this retrospective study, we examined 66 patients 18 years of age or older undergoing therapeutic hypothermia for cardiac arrest between 2007 and 2010 to assess the relationship of temperature dose with outcomes. Read More

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Simulation-based assessment of trainee's performance in post-cardiac arrest resuscitation.

Resusc Plus 2022 Jun 28;10:100233. Epub 2022 Apr 28.

Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.

Objectives: To assess trainees' performance in managing a patient with post-cardiac arrest complicated by status epilepticus.

Methods: In this prospective, observational, single-center simulation-based study, trainees ranging from sub interns to critical care fellows evaluated and managed a post cardiac arrest patient, complicated by status epilepticus. Critical action items were developed by a modified Delphi approach based on American Heart Association guidelines and the Neurocritical Care Society's Emergency Neurological Life Support protocols. Read More

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The impact of mild therapeutic hypothermia on platelet reactivity in comatose survivors of cardiac arrest with acute myocardial infarction treated with ticagrelor.

Cardiol J 2022 May 6. Epub 2022 May 6.

Department of Cardiology, Nicolaus Copernicus University, Torun, Poland.

Background: The aim of the study was to assess the antiplatelet effect of ticagrelor in patients with myocardial infarction (MI) after out-of-hospital cardiac arrest (OHCA) treated with percutaneous coronary intervention (PCI) and mild therapeutic hypothermia (MTH) vs. MI patients without OHCA treated with PCI.

Methods: The study was designed and performed as a phase IV, single-center, investigator-initiated, prospective, observational study assessing the early pharmacodynamic effect (within first 24 h) of a ticagrelor loading dose (180 mg) in both groups of patients (MTH group vs. Read More

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Thrombotic Microangiopathy Score as a New Predictor of Neurologic Outcomes in Patients after Out-of-Hospital Cardiac Arrest.

Yonsei Med J 2022 May;63(5):461-469

Department of Emergency Medicine, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Given the morphological characteristics of schistocytes, thrombotic microangiopathy (TMA) score can be beneficial as it can be automatically and accurately measured. This study aimed to investigate whether serial TMA scores until 48 h post admission are associated with clinical outcomes in patients undergoing targeted temperature management (TTM) after out-of-hospital cardiac arrest (OHCA).

Materials And Methods: We retrospectively evaluated a cohort of 185 patients using a prospective registry. Read More

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Physiological responses to cuddling babies with hypoxic-ischaemic encephalopathy during therapeutic hypothermia: an observational study.

BMJ Paediatr Open 2021 Dec 16;5(1). Epub 2021 Dec 16.

Neonatology, St Michael's Hospital, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK

Objectives: To determine whether parents cuddling infants during therapeutic hypothermia (TH) would affect cooling therapy, cardiorespiratory or neurophysiological measures. The secondary aim was to explore parent-infant bonding, maternal postnatal depression and breastfeeding.

Design: Prospective observational study. Read More

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December 2021

Therapeutic hypothermia attenuates physiologic, histologic, and metabolomic markers of injury in a porcine model of acute respiratory distress syndrome.

Physiol Rep 2022 05;10(9):e15286

Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada.

Acute respiratory distress syndrome (ARDS) is a lung injury characterized by noncardiogenic pulmonary edema and hypoxic respiratory failure. The purpose of this study was to investigate the effects of therapeutic hypothermia on short-term experimental ARDS. Twenty adult female Yorkshire pigs were divided into four groups (n = 5 each): normothermic control (C), normothermic injured (I), hypothermic control (HC), and hypothermic injured (HI). Read More

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Artificial neural network-boosted Cardiac Arrest Survival Post-Resuscitation In-hospital (CASPRI) score accurately predicts outcome in cardiac arrest patients treated with targeted temperature management.

Sci Rep 2022 May 4;12(1):7254. Epub 2022 May 4.

Department of Neurology, Shuang Ho Hospital, Taipei Medical University, 291, Zhongzheng Road, Zhonghe District, New Taipei City, 235, Taiwan, ROC.

Existing prognostic models to predict the neurological recovery in patients with cardiac arrest receiving targeted temperature management (TTM) either exhibit moderate accuracy or are too complicated for clinical application. This necessitates the development of a simple and generalizable prediction model to inform clinical decision-making for patients receiving TTM. The present study explores the predictive validity of the Cardiac Arrest Survival Post-resuscitation In-hospital (CASPRI) score in cardiac arrest patients receiving TTM, regardless of cardiac event location, and uses artificial neural network (ANN) algorithms to boost the prediction performance. Read More

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[Current status of Therapeutic Hypothermia in Hypoxic-Ischemic Encephalopathy].

Andes Pediatr 2021 Dec 30;92(6):831-837. Epub 2022 Mar 30.

Fundación NeNe, Madrid, España.

Therapeutic hypothermia (TH) has been the standard treatment for neonatal Hypoxic-Ischemic En cephalopathy (HIE) for more than a decade. This therapy has been one of the best studied treatments in neonatal medicine, moving from preclinical models to patient application. Its implementation has been accompanied by the development of neuromonitoring, neonatal neurology as a specific area of expertise, and the intense search for new neuroprotective strategies. Read More

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December 2021

[Antidepressant overdose resulting in coma and hypothermia].

Ned Tijdschr Geneeskd 2022 02 22;166. Epub 2022 Feb 22.

Medisch Centrum Leeuwarden, Leeuwarden: Afd. Spoedeisende Hulp.

Background: Cognitive disorders lead to an increased risk of misuse of medication, resulting in possible auto-intoxication.

Case Description: We describe the case of a 68-year-old patient, with hypothermia and a coma, with accidental tricyclic antidepressant (TCA) intoxication. What is remarkable about this case is that there were no cardiac or hemodynamic abnormalities, which is to be expected with both hypothermia and TCA-intoxication. Read More

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February 2022

Non-Invasive Monitoring of Core Body Temperature for Targeted Temperature Management in Post-Cardiac Arrest Care.

Front Med (Lausanne) 2022 13;9:810825. Epub 2022 Apr 13.

Division of Critical Care, Department of Medicine, London Health Sciences Centre, London, ON, Canada.

Importance: Accurate monitoring of core body temperature is integral to targeted temperature management (TTM) following cardiac arrest. However, there are no reliable non-invasive methods for monitoring temperature during TTM.

Objectives: We compared the accuracy and precision of a novel non-invasive Zero-Heat-Flux Thermometer (SpotOn™) to a standard invasive esophageal probe in a cohort of patients undergoing TTM post-cardiac arrest. Read More

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The association of fetal acidemia with adverse neonatal outcomes at time of scheduled cesarean delivery.

Am J Obstet Gynecol 2022 Apr 27. Epub 2022 Apr 27.

Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO.

Background: Fetal acidemia at the time of a scheduled cesarean delivery is generally unexpected. In the setting of reassuring preoperative monitoring, the duration of fetal acidemia in this scenario is presumably brief. The neonatal sequelae and risks associated with brief fetal acidemia in this setting are unknown. Read More

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Opioid exposure during therapeutic hypothermia and short-term outcomes in neonatal encephalopathy.

J Perinatol 2022 Apr 26. Epub 2022 Apr 26.

Pediatrics, Washington University in St. Louis, St. Louis, MO, USA.

Objective: To assess the association between opioid exposure during therapeutic hypothermia (TH) for perinatal hypoxic-ischemic encephalopathy (HIE) and in-hospital outcomes.

Study Design: In this retrospective cohort study, linked data were accessed on infants ≥36 weeks gestation, who underwent TH for HIE, born from 2010-2016 in 23 Neonatal Intensive Care Units participating in Children's Hospitals Neonatal Consortium and Pediatric Health Information Systems. We excluded infants who received opioids for >5 days. Read More

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