29,831 results match your criteria Therapeutic Hypothermia


Oral gavage of capsaicin causes TRPV1-dependent acute hypothermia and TRPV1-independent long-lasting increase of locomotor activity in the mouse.

Physiol Behav 2019 Apr 19. Epub 2019 Apr 19.

Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan. Electronic address:

Capsaicin (CAP), the pungent ingredient of hot red pepper, is a selective ligand for the heat-sensitive transient receptor potential V1 cation channel 1 (TRPV1). Although CAP has been traditionally used as the ingredient of spices for various foods in the world, the effect of oral intake of CAP on thermoregulation and locomotor activity, and CAP-induced activation of brain neural circuits are not well understood. In this study, therefore, we examined the effects of oral gavage of CAP on core body and tail surface temperature, locomotor activity, and Fos expression in thermoregulation- and sensory information-associated hypothalamic and medullary brain regions using freely moving mice. Read More

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http://dx.doi.org/10.1016/j.physbeh.2019.04.015DOI Listing

Nutrition During Targeted Temperature Management After Cardiac Arrest: Observational Study of Neurological Outcomes and Nutrition Tolerance.

JPEN J Parenter Enteral Nutr 2019 Apr 22. Epub 2019 Apr 22.

Médecine Intensive Réanimation, University Hospital Centre, Nantes, France.

Background: Whether providing nutrition support is beneficial or deleterious during targeted temperature management (TTM) after cardiac arrest is unclear. We therefore performed a retrospective observational study to determine whether early nutrition was beneficial or deleterious during TTM.

Methods: We retrospectively studied patients admitted to our intensive care unit (ICU) between 2008 and 2014 after successfully resuscitated cardiac arrest. Read More

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http://dx.doi.org/10.1002/jpen.1596DOI Listing

White Matter Lesions Detected by Magnetic Resonance Imaging in Neonates and Children With Congenital Myotonic Dystrophy.

Pediatr Neurol 2019 Mar 13. Epub 2019 Mar 13.

Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; University of Cincinnati, College of Medicine, Cincinnati, Ohio. Electronic address:

Background: Congenital myotonic dystrophy (CDM1) is an autosomal dominant genetic disorder caused by abnormal cytosine-thymine-guanine trinucleotide repeat expansion that results in weakness and cognitive deficits. Studies detailing brain magnetic resonance imaging (MRI) findings in neonates and children with this condition are limited.

Objective: We evaluated the brain MRI findings in children, including neonates with CDM1, to assess the nature of central nervous system involvement and progression of MRI lesions over time. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08878994183114
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http://dx.doi.org/10.1016/j.pediatrneurol.2019.03.004DOI Listing
March 2019
1 Read

Systematic Review: Long-term cognitive and behavioural outcomes of neonatal hypoxic-ischaemic encephalopathy in children without cerebral palsy.

Acta Paediatr 2019 Apr 19. Epub 2019 Apr 19.

Department of Neonatal Medicine, Southampton Children's Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Aim: To evaluate long-term cognitive and behavioural outcomes of children with neonatal hypoxic-ischaemic encephalopathy in the absence of cerebral palsy.

Methods: A systematic search was performed on five databases (EMBASE, Medline, PubMed, Web of Science, PsycInfo). Randomised-controlled trials, non-randomised controlled trials, or observational studies, published between 1990-2017, that reported long-term (age ≥ 4 years) cognitive and/or behavioural outcomes of neonatal hypoxic-ischaemic encephalopathy without cerebral palsy were included. Read More

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http://dx.doi.org/10.1111/apa.14821DOI Listing

Decompression Hemicraniectomy for Refractory Intracranial Hypertension in Reversible Cerebral Vasoconstriction Syndrome.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):355-359

Division of Neurocritical Care, Cerebrovascular Center, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Reversible cerebral vasoconstriction syndrome (RCVS) is a disorder of dysregulation of cerebrovascular tone resulting in transient segmental vasoconstriction which resolves in 1-3 months. Cerebral edema is an underrecognized complication in RCVS. It is likely multifactorial. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_334_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454955PMC

Predicting survival in out-of-hospital cardiac arrest patients undergoing targeted temperature management: The Polish Hypothermia Registry Risk Score.

Cardiol J 2019 Apr 17. Epub 2019 Apr 17.

Intensive Cardiac Therapy Clinic, Institute of Cardiology Warsaw, Poland.

Background: Prompt reperfusion and post-resuscitation care, including targeted temperature management (TTM), improve survival in out-of-hospital cardiac arrest (OHCA) patients. To predict in-hospital mortality in OHCA patients treated with TTM, the Polish Hypothermia Registry Risk Score (PHR-RS) was developed. The use of dedicated risk stratification tools may support treatment decisions. Read More

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https://journals.viamedica.pl/cardiology_journal/article/vie
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http://dx.doi.org/10.5603/CJ.a2019.0035DOI Listing
April 2019
3 Reads

Impact of adrenaline dose and timing on out-of-hospital cardiac arrest survival and neurological outcomes.

Resuscitation 2019 Apr 13. Epub 2019 Apr 13.

Center for Resuscitation Science and the Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Study Objective: The 2015 ILCOR Advanced Cardiovascular Life Support Guidelines recommend intravenous adrenaline (epinephrine) as a crucial pharmacologic treatment during cardiac arrest resuscitation. Some recent observational studies and clinical trials have questioned the efficacy of its use and suggested possible deleterious effects on overall survival and long-term outcomes. This study aimed to describe the association between time and dose of adrenaline on return of spontaneous circulation (ROSC) and neurologic function. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.018DOI Listing
April 2019
1 Read

Myocardial hypothermia induced after reperfusion does not prevent adverse left ventricular remodeling nor improve cardiac function.

Life Sci 2019 Apr 13. Epub 2019 Apr 13.

HMRI Cardiovascular Research Institute, Huntington Medical Research Institutes, 686 South Fair Oaks Avenues, Pasadena, CA 91105, United States of America.

Aims: The purpose of the study was to determine whether late therapeutic hypothermia (LTH), administered after reperfusion, could prevent adverse left ventricular (LV) remodeling and improve cardiac function in the rat myocardial ischemia/reperfusion model.

Main Methods: Rats were randomized to normothermia (n = 10) or LTH (initiated at 1 min after coronary artery reperfusion, n = 10) and subjected to 30 min of coronary occlusion followed by 6 weeks of reperfusion. Hypothermia was induced by pumping cold saline over the anterior surface of the LV until the temperature cooled to <32 °C. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.026DOI Listing
April 2019
2 Reads

Maternal consumption of piceatannol: a nutritional neuroprotective strategy against hypoxia-ischemia in rat neonates.

Brain Res 2019 Apr 13. Epub 2019 Apr 13.

CRMSB, UMR 5536, CNRS/University of Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux Cedex, France. Electronic address:

Hypoxia-ischemia (HI) remains a major cause of perinatal mortality and chronic disability in newborns worldwide (1-6 for 1,000 births) with a high risk of future motor, behavioral and neurological deficits. Keeping newborns under moderate hypothermia is the unique therapeutic approach but is not sufficiently successful as nearly 50% of infants do not respond to it. In a 7-day post-natal rat model of HI, we used pregnant and breastfeeding female nutritional supplementation with piceatannol (PIC), a polyphenol naturally found in berries, grapes and passion fruit, as a neuroprotective strategy. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.012DOI Listing
April 2019
1 Read

The Effects of Pharmacological Hypothermia Induced by Neurotensin Receptor Agonist ABS 201 on Outcomes of CPR.

Shock 2019 May;51(5):667-673

Weil Institute of Emergency and Critical Care Research, Virginia Commonwealth University, Richmond, Virginia.

Neurotensin is an endogenous tridecapeptide that binds to neurotensin receptors in the brain, which induce hypothermia. The aim of this study was to investigate whether the receptor agonist ABS 201 could induce therapeutic hypothermia and improve postresuscitation outcomes in a ventricular fibrillation cardiac arrest (VFCA) rat model. VF was electrically induced in 12 rats. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001178DOI Listing
May 2019
1 Read

Efficacy of forced-air warming and warmed intravenous fluid for prevention of hypothermia and shivering during caesarean delivery under spinal anaesthesia: A randomised controlled trial.

Eur J Anaesthesiol 2019 Apr 5. Epub 2019 Apr 5.

From the Department of Anaesthesiology and Pain Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.

Background: Peri-operative hypothermia and shivering are frequent events in patients during caesarean delivery under spinal anaesthesia.

Objective: We assessed the efficacy of combined pre-anaesthetic forced-air warming in combination with warmed intravenous fluid infusion for preventing hypothermia and shivering during caesarean delivery under spinal anaesthesia.

Design: A randomised controlled study. Read More

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http://dx.doi.org/10.1097/EJA.0000000000000990DOI Listing
April 2019
1 Read

Shoshin Beriberi and Severe Accidental Hypothermia as Causes of Heart Failure in a 6-Year-Old Child: A Case Report and Brief Review of Literature.

Front Pediatr 2019 29;7:119. Epub 2019 Mar 29.

Pediatric Intensive Care Department, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, Brussels, Belgium.

Severe accidental hypothermia has been demonstrated to affect ventricular systolic and diastolic functions, and rewarming might be responsible of cardiovascular collapse. Until now, there have been only a few reports on severe accidental hypothermia, none of which involved children. Herein, we describe here a rare case of heart failure in a 6-year-old boy admitted to the emergency unit owing to severe hypothermia and malnutrition. Read More

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http://dx.doi.org/10.3389/fped.2019.00119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449648PMC
March 2019
1 Read

Effect of hypothermia on the functional activity of liver mitochondria of grass snake (Natrix natrix): inhibition of succinate-fueled respiration and K transport, ROS-induced activation of mitochondrial permeability transition.

J Bioenerg Biomembr 2019 Apr 13. Epub 2019 Apr 13.

Mari State University, pl. Lenina 1, Yoshkar-Ola, Mari El, 424001, Russia.

The article considers the comparative analysis of the functional activity of mitochondria isolated from the liver of grass snakes, Natrix natrix (Linnaeus, 1758) that were kept at different temperatures (23-26 °C and 4-5 °C). It was found that liver mitochondria of hypothermia-exposed grass snakes are characterized by weak coupling of oxidative phosphorylation as compared to mitochondria of active animals which is caused by inhibition of succinate-fuelled respiration in ADP-stimulated state, as well as by activation of basal non-phosphorylating rate. Inhibition of mitochondrial respiration in hibernating animals is associated with a decrease in the activity of the respiratory chain complexes of organelles. Read More

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http://dx.doi.org/10.1007/s10863-019-09796-6DOI Listing
April 2019
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A Prospective Clinical Trial Measuring the Effects of Cardiopulmonary Bypass Under Mild Hypothermia on the Inflammatory Response and Regulation of Cold-Shock Protein RNA-Binding Motif 3.

Ther Hypothermia Temp Manag 2019 Apr 11. Epub 2019 Apr 11.

1 Department of Congenital Heart Disease and Pediatric Cardiology, German Heart Institute Berlin, Berlin, Germany.

Therapeutic hypothermia during cardiac surgery has been widely used for neuroprotection and to attenuate the systemic inflammatory response due to cardiopulmonary bypass (CPB). Experimental data suggest that cold-shock protein RNA-binding motif 3 (RBM3), which is induced in response to hypothermia, plays a key role in hypothermia-induced organ protection. To date, investigation on RBM3 has been performed exclusively in vitro or in animal models, and the detection and regulation of RBM3 in human blood has not been investigated until now. Read More

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http://dx.doi.org/10.1089/ther.2018.0038DOI Listing
April 2019
1 Read

A Successful Whole Body Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy During an ECMO Run in a Newborn.

Front Pediatr 2019 22;7:95. Epub 2019 Mar 22.

Division of Neonatology, Department of Pediatrics, Ankara University School of Medicine, Ankara, Turkey.

Data regarding the safety of using therapeutic hypothermia (TH) with extracorporeal membrane oxygenation (ECMO) in neonates with both hypoxic ischemic encephalopathy (HIE), and respiratory failure are lacking. TH is not associated with an increased incidence of hemostatic complications, but hypothermia may impair coagulation. Herein, we report a case of a newborn who had meconium aspiration syndrome and HIE and underwent both TH and ECMO. Read More

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http://dx.doi.org/10.3389/fped.2019.00095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439343PMC
March 2019
1 Read

Human Umbilical Cord Therapy Improves Long-Term Behavioral Outcomes Following Neonatal Hypoxic Ischemic Brain Injury.

Front Physiol 2019 22;10:283. Epub 2019 Mar 22.

The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.

Hypoxic ischemic (HI) insult in term babies at labor or birth can cause long-term neurodevelopmental disorders, including cerebral palsy (CP). The current standard treatment for term infants with hypoxic ischemic encephalopathy (HIE) is hypothermia. Because hypothermia is only partially effective, novel therapies are required to improve outcomes further. Read More

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http://dx.doi.org/10.3389/fphys.2019.00283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440382PMC
March 2019
1 Read

Protein malnutrition prevents heat conservation induced by amino acid infusion during general anesthesia in rats.

Nutr Res 2019 Mar 4. Epub 2019 Mar 4.

Department of Anesthesiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan.

The intravenous administration of an amino acid (AA) mixture during general anesthesia reduces anesthesia-induced hypothermia. AA-induced skeletal muscle protein synthesis and thermogenesis play important roles in the antihypothermic effects of AAs. We hypothesized that a preanesthetic dietary protein deficiency impairs the antihypothermic effects of AAs during general anesthesia due to a reduction in thermogenesis caused by a decrease in muscle protein synthesis. Read More

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http://dx.doi.org/10.1016/j.nutres.2019.02.007DOI Listing
March 2019
1 Read

Current practices in deceased organ donor management.

Curr Opin Organ Transplant 2019 Apr 5. Epub 2019 Apr 5.

Department of Surgery, Division of Transplant, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Purpose Of Review: Optimizing the management of deceased organ donors focuses on providing critical care that prevents, mitigates, or repairs the pathophysiologic sequelae of brain death. This review discusses protocol-based care; approaches to monitoring, resuscitation, hormone replacement therapy, and respiratory management; and the potential of various additional donor therapies.

Recent Findings: Protocol-based critical care after the determination of brain death has the potential to substantially increase the quantity and improve the quality of organs available for transplantation. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000638DOI Listing
April 2019
2 Reads

Correction: Respiratory management during therapeutic hypothermia for hypoxic-ischemic encephalopathy.

J Perinatol 2019 Apr 8. Epub 2019 Apr 8.

Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.

A correction to this paper has been published and can be accessed via a link at the top of the paper. Read More

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http://dx.doi.org/10.1038/s41372-019-0371-4DOI Listing
April 2019
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Hypothermia Masks Most of the Effects of Rapid Cycling VNS on Rat Hippocampal Electrophysiology.

Int J Neural Syst 2019 Feb 14:1950008. Epub 2019 Feb 14.

1 Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology, Ghent University, Corneel Heymanslaan 10 Ghent, Flanders, Belgium.

Aim: Vagus nerve stimulation (VNS) modulates hippocampal dentate gyrus (DG) electrophysiology and induces hypothermia in freely moving rats. This study evaluated whether hippocampal (CA1) electrophysiology is similarly modulated and to what extent this is associated with VNS-induced hypothermia.

Methods: Six freely moving rats received a first 4 h session of rapid cycling VNS (7 s on/18 s off), while CA1 evoked potentials, EEG and core temperature were recorded. Read More

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http://dx.doi.org/10.1142/S0129065719500084DOI Listing
February 2019
2 Reads

Assessment of fed-batch cultivation strategies for an inducible CHO cell line.

J Biotechnol 2019 Apr 5;298:45-56. Epub 2019 Apr 5.

Department of Chemical Engineering, École Polytechnique de Montréal, P.O. Box 6079, succ. Centre-Ville, Montréal QC, H3C 3A7, Canada. Electronic address:

In order to maximize cell growth and productivity for an inducible CHO cell line expressing rituximab, various fed-batch culture strategies were investigated. In each case, the performance was evaluated for cultures induced at moderate and high cell density conditions (4 × 10 and 10 × 10 cells/mL) to assess the impact of the timing of induction. We first demonstrate the importance of starting the feeding process during the growth phase, as this translated into significantly improved integral of viable cells and antibody concentration, when compared to post-induction feeding only. Read More

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http://dx.doi.org/10.1016/j.jbiotec.2019.04.005DOI Listing
April 2019
3 Reads

The role of mitochondrial and endoplasmic reticulum ROS production in models of perinatal brain injury.

Antioxid Redox Signal 2019 Apr 8. Epub 2019 Apr 8.

University of Gothenburg, 3570, Centre of Perinatal Medicine and Health, Sahlgrenska Academy, Gothenburg, Sweden.

Significance: Perinatal brain injury is caused by hypoxia-ischemia (HI) in term neonates, perinatal arterial stroke, and infection/inflammation leading to devastating long-term neurodevelopmental deficits. Therapeutic hypothermia is the only currently available treatment but is not successful in more than 50% of term neonates suffering from hypoxic-ischemic encephalopathy. Thus, there is an urgent unmet need for alternative or adjunct therapies. Read More

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http://dx.doi.org/10.1089/ars.2019.7779DOI Listing
April 2019
1 Read

Mesenchymal Stromal Cell Derived Extracellular Vesicles Reduce Hypoxia-Ischaemia Induced Perinatal Brain Injury.

Front Physiol 2019 19;10:282. Epub 2019 Mar 19.

Perinatal Brain Protection and Repair Group, EGA Institute for Women's Health, University College London, London, United Kingdom.

Background: Neonatal hypoxic-ischemic (HI) insult is a leading cause of disability and death in newborns, with therapeutic hypothermia being the only currently available clinical intervention. Thus there is a great need for adjunct and novel treatments for enhanced or alternative post-HI neuroprotection. Extracellular vesicles (EVs) derived from mesenchymal stromal/stem cells (MSCs) have recently been shown to exhibit regenerative effects in various injury models. Read More

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http://dx.doi.org/10.3389/fphys.2019.00282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433879PMC
March 2019
6 Reads

Variability in the Drug Response of M Muscarinic Receptor Knockout Mice During Day and Night Time.

Front Pharmacol 2019 18;10:237. Epub 2019 Mar 18.

Institute of Physiology, First Faculty of Medicine, Charles University, Prague, Czechia.

Mice are nocturnal animals. Surprisingly, the majority of physiological/pharmacological studies are performed in the morning, i.e. Read More

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http://dx.doi.org/10.3389/fphar.2019.00237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431655PMC
March 2019
3 Reads

Change in neuron specific enolase levels in out-of-hospital cardiopulmonary arrest survivors as a simple and useful tool to predict neurological prognosis.

Rev Esp Cardiol (Engl Ed) 2019 Mar 29. Epub 2019 Mar 29.

Unidad de Críticos Cardiovasculares, Departamento de Cardiología, Hospital Universitari Vall d'Hebron, Barcelona, Spain; Centro de Investigación Biomédica En Red enfermedades Cardiovasculares (CIBERCV), Fundación Hospital Universitario Vall d'Hebron-Institut de Recerca (VHIR), Barcelona, Spain. Electronic address:

Introduction And Objectives: Neuron-specific enolase (NSE) is a prognostic marker in out-of-hospital cardiopulmonary arrest (OHCA) survivors treated with mild therapeutic hypothermia (MTH). The objectives were to analyze the correlation between dynamic changes in NSE and outcomes and to determine the measurement timing that best predicts neurological status.

Methods: Multicenter cohort study including patients admitted after shockable rhythm OHCA and treated with MTH. Read More

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http://dx.doi.org/10.1016/j.rec.2019.01.007DOI Listing
March 2019
2 Reads

Attention and visuo-spatial function in children without cerebral palsy who were cooled for neonatal encephalopathy: a case-control study.

Brain Inj 2019 Mar 29:1-5. Epub 2019 Mar 29.

d Translational Health Sciences, Bristol Medical School, St Michael's Hospital , University of Bristol , UK.

Objectives: Dorsal-stream functions are vulnerable to early brain injury associated with neonatal encephalopathy (NE) following perinatal asphyxia, even in children not developing cerebral palsy (CP). Since therapeutic hypothermia (TH) became the standard treatment for NE, the incidence of CP is reduced but the impact on dorsal-stream functions is unknown. We aimed to compare dorsal-stream functions in TH-treated survivors of NE, without CP, with those of matched controls. Read More

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https://www.tandfonline.com/doi/full/10.1080/02699052.2019.1
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http://dx.doi.org/10.1080/02699052.2019.1597163DOI Listing
March 2019
3 Reads

Relationships between three and twelve month outcomes in children enrolled in the therapeutic hypothermia after pediatric cardiac arrest trials.

Resuscitation 2019 Mar 26. Epub 2019 Mar 26.

Department of Pediatrics, University of Michigan, CS Mott Children's Hospital, 1500 East Medical Center Drive, Ann Arbor, MI, 48109, USA.

Aim: To inform design aspects of future trials by comparing 3 and 12-month neurobehavioural outcomes in children enrolled in Therapeutic Hypothermia After Pediatric Cardiac Arrest Out-Of-Hospital and In-Hospital (THAPCA-OH, THAPCA-IH) trials.

Methods: The THAPCA trials evaluated two targeted temperature management interventions (hypothermia, 32.0-34. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.020DOI Listing
March 2019
2 Reads

Metabolic effects of beta-blockers in critically ill patients: A retrospective cohort study.

Heart Lung 2019 Mar 26. Epub 2019 Mar 26.

Department of Intensive Care Medicine, Head of ICU, Gelderse Vallei Hospital, Willy Brandtlaan 10, 6716 RP, Ede, the Netherlands. Electronic address:

Background: Beta-blockers have potential protective features during critical illness. Heart rate reduction, with limited effect on blood pressure and beneficial effects on metabolism, organ function and inflammation have been reported. We examined metabolic effects of beta-blockers among ICU patients, to address the effect on the estimated energy expenditure, measured by carbon dioxide production (VCO). Read More

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http://dx.doi.org/10.1016/j.hrtlng.2019.02.004DOI Listing
March 2019
1 Read

Early proton magnetic resonance spectroscopy during and after therapeutic hypothermia in perinatal hypoxic-ischemic encephalopathy.

Pediatr Radiol 2019 Mar 28. Epub 2019 Mar 28.

Department of Obstetrics and Gynecology, Baylor College of Medicine, Texas Children's Hospital Pavilion for Women, Houston, TX, USA.

Background: Hypoxic-ischemic encephalopathy (HIE) remains a significant cause of mortality and neurodevelopmental impairment despite treatment with therapeutic hypothermia. Magnetic resonance H-spectroscopy measures concentrations of cerebral metabolites to detect derangements in aerobic metabolism.

Objective: We assessed MR spectroscopy in neonates with HIE within 18-24 h of initiating therapeutic hypothermia and at 5-6 days post therapeutic hypothermia. Read More

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http://dx.doi.org/10.1007/s00247-019-04383-8DOI Listing
March 2019
3 Reads

Effector and Activated T Cells Induce Preterm Labor and Birth That Is Prevented by Treatment with Progesterone.

J Immunol 2019 Mar 27. Epub 2019 Mar 27.

Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Detroit, MI 48201;

Preterm labor commonly precedes preterm birth, the leading cause of perinatal morbidity and mortality worldwide. Most research has focused on establishing a causal link between innate immune activation and pathological inflammation leading to preterm labor and birth. However, the role of maternal effector/activated T cells in the pathogenesis of preterm labor/birth is poorly understood. Read More

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http://dx.doi.org/10.4049/jimmunol.1801350DOI Listing
March 2019
2 Reads
4.922 Impact Factor

Mild hypothermia affects the morphology and impairs glutamine-induced anabolic response in human primary myotubes.

Am J Physiol Cell Physiol 2019 Mar 27. Epub 2019 Mar 27.

Department of Health Sciences, Örebro University, Örebro, Sweden.

The specific impact of reduced temperature on skeletal muscle adaptation has been poorly investigated. Cold water immersion, one situation leading to decreased skeletal muscle temperature, is commonly proposed to reduce the perception of fatigue and muscle soreness after strenuous exercise. In contrast, it may impair long-term benefits of resistance exercise training on muscle strength and hypertrophy. Read More

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http://dx.doi.org/10.1152/ajpcell.00008.2019DOI Listing
March 2019
3 Reads

Rapid free thiol rebound is a physiological response following cold-induced vasoconstriction in healthy humans, primary Raynaud and systemic sclerosis.

Physiol Rep 2019 Mar;7(6):e14017

Department of Internal Medicine, Division Vascular Medicine, University of Groningen - University Medical Centre Groningen, Groningen, The Netherlands.

Raynaud's phenomenon (RP) is often the first sign of systemic sclerosis (SSc). Molecular mechanisms involved are incompletely understood, but reactive oxygen, nitrogen, and sulfur species are thought to play an important role in the pathogenesis of SSc. Free thiol groups play a protective role against oxidative stress and may represent an attractive therapeutic target. Read More

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http://dx.doi.org/10.14814/phy2.14017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436142PMC

Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies.

Int J Endocrinol 2019 20;2019:9626715. Epub 2019 Feb 20.

Department of Medical Physics, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology Gliwice Branch, Poland.

Melatonin may serve as a potential therapeutic free radical scavenger and broad-spectrum antioxidant. It shows neuroprotective properties against hypoxic-ischemic brain injury in animal models. The authors review the studies focusing on the neuroprotective potential of melatonin and its possibility of treatment after perinatal asphyxia. Read More

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http://dx.doi.org/10.1155/2019/9626715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402213PMC
February 2019
1 Read

Carotid chemoreceptor denervation does not impair hypoxia-induced thermal downregulation but vitiates recovery from a hypothermic and hypometabolic state in mice.

Sci Rep 2019 Mar 26;9(1):5132. Epub 2019 Mar 26.

Department of Surgery, Amsterdam University Medical Centers, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Induction of hypothermia and consequent hypometabolism by pharmacological downmodulation of the internal thermostat could be protective in various medical situations such as ischemia/reperfusion. Systemic hypoxia is a trigger of thermostat downregulation in some mammals, which is sensed though carotid chemoreceptors (carotid bodies, CBs). Using non-invasive thermographic imaging in mice, we demonstrated that surgical bilateral CB denervation does not hamper hypoxia-induced hypothermia. Read More

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http://dx.doi.org/10.1038/s41598-019-41546-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435667PMC
March 2019
1 Read

Neuroprotective effects of inter-alpha inhibitor proteins after hypoxic-ischemic brain injury in neonatal rats.

Exp Neurol 2019 Mar 23;317:244-259. Epub 2019 Mar 23.

Department of Pediatrics, Women & Infants Hospital of Rhode Island, USA; The Warren Alpert Medical School of Brown University, USA. Electronic address:

Hypoxic-ischemic (HI) brain injury is one of the most common neurological problems occurring in the perinatal period. Hypothermia is the only approved intervention for neonatal HI encephalopathy. However, this treatment is only partially protective, has a narrow therapeutic time window after birth and only can be used to treat full-term infants. Read More

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http://dx.doi.org/10.1016/j.expneurol.2019.03.013DOI Listing
March 2019
1 Read

[Progress in pharmaceutical research for cerebral resuscitation after cardiac arrest].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2019 Mar;31(3):371-374

Department of Critical Care Medicine, People's Hospital of Wuhan University, Wuhan 430060, Hubei, China. Corresponding author: Yu Zhui, Email:

Objective: With the popularization of cardiopulmonary resuscitation (CPR) technology, the success rate of restoration of spontaneous circulation (ROSC) is gradually improved, and the survival rate and neurological outcome of patients with cardiac arrest are improved. Currently, therapeutic methods for cerebral resuscitation after cardiac arrest are limited. In addition to mild hypothermia for clinical application, the majority of drugs remain in the animal experimental stage. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2019.03.023DOI Listing
March 2019
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Targeted Temperature Management for Subarachnoid Hemorrhage: Excellent Outcome After Severe Vasospasm A Case Series.

Ther Hypothermia Temp Manag 2019 Mar 26. Epub 2019 Mar 26.

1 Klinik für Neurologie und Neurointensivmedizin, Klinikum Darmstadt, Darmstadt, Germany.

Targeted temperature management (TTM) might improve outcome of patients with severe subarachnoid hemorrhage (SAH) in which vasospasm, delayed cerebral ischemia (DCI), and increased intracranial pressure (ICP) are frequent and severe complications. A series of patients (n = 3) with severe aneurysmatic SAH were treated by TTM if they developed ICP crisis and/or severe vasospasm diagnosed by angiography. Once these complications were detected, body core temperature (BCT) was rapidly decreased to 35°C or 33°C, if necessary. Read More

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http://dx.doi.org/10.1089/ther.2018.0049DOI Listing
March 2019
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Mild hypothermia promotes the viability of in vitro-produced bovine blastocysts and their transcriptional expression of the cold-inducible transcription factor Rbm3 during in vitro culture.

J Reprod Dev 2019 Mar 23. Epub 2019 Mar 23.

Laboratory of Reproductive Biology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.

In this study, we evaluated the effects of holding in vitro-produced bovine blastocysts under mild hypothermia (33°C or 35°C), by examining viability and hatching rates of day 7 blastocysts (day 0: in vitro fertilization) cultured for 6 days and transcriptional expression of cold-inducible transcription factors Cirp and Rbm3, implicated in mild hypothermia-induced cellular protection against various types of stress. In the normothermic control (38.5°C), viability of the embryos decreased rapidly after day 10, and most samples were degenerated on day 13. Read More

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http://dx.doi.org/10.1262/jrd.2018-142DOI Listing
March 2019
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Association of cerebral activity with MRI scans in infants with neonatal encephalopathy undergoing therapeutic hypothermia.

Eur J Pediatr 2019 Mar 21. Epub 2019 Mar 21.

Faculty of Health sciences, Ben Gurion University of the Negev, Be'er Sheva, Israel.

We aimed to correlate amplitude-integrated EEG (aEEG) in neonatal hypoxic ischemic encephalopathy (HIE) with early magnetic resonance imaging (MRI). In this retrospective study, 32 neonates over 35 weeks' gestation with moderate/severe HIE who were treated with hypothermia were included. Early MRI scans and daily aEEG background were categorized to mild/normal, moderate, and severely abnormal. Read More

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http://dx.doi.org/10.1007/s00431-019-03364-1DOI Listing
March 2019
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Current Practice of Therapeutic Hypothermia for Mild Hypoxic Ischemic Encephalopathy.

J Child Neurol 2019 Mar 22:883073819828625. Epub 2019 Mar 22.

1 Department of Neonatology, Princess Margaret and King Edward Hospitals, Perth, Australia.

Context:: Therapeutic hypothermia is the recommended treatment for neonates with moderate or severe hypoxic ischemic encephalopathy (HIE). There is an increasing trend to use therapeutic hypothermia even in infants with mild hypoxic ischemic encephalopathy, even though there is little evidence to support/refute this.

Objective:: To estimate the incidences of mild hypoxic ischemic encephalopathy among infants who received therapeutic hypothermia, and its short- and long-term outcomes. Read More

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http://dx.doi.org/10.1177/0883073819828625DOI Listing
March 2019
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Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16.

Cell Rep 2019 Mar;26(12):3221-3230.e3

Department of Medical Science, Graduate School of Medicine, Hiroshima University, Hiroshima City, Hiroshima 734-8553, Japan. Electronic address:

Non-shivering thermogenesis in adipocytes provides defense against low temperatures and obesity development, but the underlying regulatory mechanism remains to be fully clarified. Based on both markedly increased Pin1 expression in states of excess nutrition and resistance to obesity development in Pin1 null mice, we speculated that adipocyte Pin1 may play a role in thermogenic programs. Adipose-specific Pin1 knockout (adPin1 KO) mice showed enhanced transcription of thermogenic genes and tolerance to hypothermia when exposed to cold. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.02.066DOI Listing
March 2019
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Esophageal Heat Exchanger Versus Water-Circulating Cooling Blanket for Targeted Temperature Management.

Ther Hypothermia Temp Manag 2019 Mar 20. Epub 2019 Mar 20.

1 Department of Anesthesiology and Intensive Care Medicine and University Hospital of Cologne, Cologne, Germany.

To date, the optimal cooling device for targeted temperature management (TTM) remains unclear. Water-circulating cooling blankets are broadly available and quickly applied but reveal inaccuracy during maintenance and rewarming period. Recently, esophageal heat exchangers (EHEs) have been shown to be easily inserted, revealed effective cooling rates (0. Read More

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http://dx.doi.org/10.1089/ther.2018.0054DOI Listing
March 2019
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Impact of Education on Hypothermia Delivery during Neonatal Transport.

Neonatology 2019 Mar 19;116(1):20-26. Epub 2019 Mar 19.

Department of Paediatrics and Child Health, University of Otago, Wellington, New Zealand.

Background: Moderate therapeutic hypothermia (TH) initiated within 6 h of life reduces adverse neurodevelopmental outcomes in infants after perinatal hypoxic ischaemic insult. For infants born in non-tertiary centres, TH may be initiated manually en route to a neonatal intensive care unit (NICU). However, both over- and undercooling is reported with this strategy, precluding some infants from the benefits of TH. Read More

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http://dx.doi.org/10.1159/000495688DOI Listing
March 2019
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Central serotonin prevents hypotension and hypothermia and reduces plasma and spleen cytokine levels during systemic inflammation.

Brain Behav Immun 2019 Mar 15. Epub 2019 Mar 15.

Department of Physiology, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil; Department of Morphology, Physiology and Basic Pathology, Dental School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil. Electronic address:

An exceptionally high mortality rate is observed in sepsis and septic shock. Systemic administration of lipopolysaccharide (LPS) has been used as an experimental model for sepsis resulting in an exacerbated immune response, brain neurochemistry adjustments, hypotension, and hypothermia followed by fever. Central serotonergic pathways not only modulate systemic inflammation (SI) but also are affected by SI, including in the anteroventral region of the hypothalamus (AVPO), which is the hierarchically most important region for body temperature (Tb) control. Read More

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http://dx.doi.org/10.1016/j.bbi.2019.03.017DOI Listing
March 2019
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Factors associated with neonatal hypoxic ischemic encephalopathy in infants with an umbilical artery pH less than 7.00.

Eur J Obstet Gynecol Reprod Biol 2019 Mar 12;236:69-74. Epub 2019 Mar 12.

Port Royal Maternity Unit, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, DHU Risks in Pregnancy, Paris Descartes University, Paris, France; INSERM UMR 1153, Obstetrical, Perinatal and Paediatric Epidemiology Research Team (EPOPé), Centre for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), France.

Objective: Our objective was to identify factors associated with hypoxic-ischemic encephalopathy (HIE) among newborns with an umbilical pH < 7.00.

Study Design: Case-control study during a four-year study period in a single academic tertiary-center, including all neonates ≥35 weeks with an umbilical pH < 7. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.02.009DOI Listing
March 2019
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Motor performance and cognitive correlates in children cooled for neonatal encephalopathy without cerebral palsy at school age.

Acta Paediatr 2019 Mar 18. Epub 2019 Mar 18.

Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Aim: To investigate whether motor performance in school-age children without cerebral palsy (CP), cooled for neonatal encephalopathy, is associated with perinatal factors and 18-month developmental scores and to explore relationships between school-age motor and cognitive performance.

Methods: Motor and cognitive performance was assessed in 29 previously cooled children at six to eight years using the Movement Assessment Battery for Children-2 (MABC-2) and the Wechsler Intelligence Scale for Children (WISC-IV). Associations between MABC-2 scores less than/equal (≤) 15th centile and perinatal factors, social/family background, 18-month Bayley-III scores and WISC-IV scores were explored. Read More

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http://dx.doi.org/10.1111/apa.14780DOI Listing
March 2019
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Cold acclimation modulates voltage gated Ca channel currents and fiber excitability in skeletal muscles of Locusta migratoria.

J Insect Physiol 2019 Apr 14;114:116-124. Epub 2019 Mar 14.

Zoophysiology, Department of Bioscience, Aarhus University, 8000 Aarhus C, Denmark.

Cold exposure is known to induce stressful imbalances in chill susceptible insects, including loss of hemolymph water, hyperkalemia and cell depolarization. Cold induced depolarization induces uncontrolled Ca influx and accumulation of injury through necrosis/apoptosis. Conversely cold induced Ca influx has been shown to induce rapid cold hardening and therefore also play a role to reduce cold injury. Read More

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http://dx.doi.org/10.1016/j.jinsphys.2019.03.003DOI Listing
April 2019
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Therapeutic hypothermia protects photoreceptors through activating Cirbp pathway.

Neurochem Int 2019 Jun 14;126:86-95. Epub 2019 Mar 14.

Department of Ophthalmology, Second Hospital of Jilin University, Changchun, PR China. Electronic address:

Therapeutic hypothermia as a physical method to lower the brain temperature of patients has been widely used in clinics as an effective and necessary step during the treatment of acute brain injury or edema. However, due to limitations of the ocular structure, the application of hypothermia in retinal neuroprotection still has an obvious barrier. Here, the neuroprotective mechanism produced by hypothermia in the retina was investigated, with the hopes of deciphering the key molecular targets of the signaling pathway to finally realize the ocular neuroprotection by regulating specific molecular targets. Read More

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http://dx.doi.org/10.1016/j.neuint.2019.03.006DOI Listing
June 2019
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Hypoxia/hypercapnia prevents iron-dependent cold injuries in cord blood stem and progenitor cells.

Cytotherapy 2019 Mar 13. Epub 2019 Mar 13.

Etablissement Français du Sang Nouvelle-Aquitaine, Bordeaux, France; Institut national de la santé et de la recherche médicale, University of Bordeaux, France. Electronic address:

Background: Cold-induced cell injuries are associated with an increase in the cellular labile iron pool (LIP) followed by lipid peroxidation and alteration of mitochondrial function, which lead to cell death. Recently, we showed that incubation in a hypoxic/hypercapnic (HH) gas mixture improved the survival of a population of cord blood hematopoietic progenitors and CD34 hematopoietic progenitor and stem cells in severe hypothermia. To explain the underlying mechanism, here we test if this HH-induced cytoprotection in cold conditions is associated with the level of LIP and lysosome stability. Read More

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http://dx.doi.org/10.1016/j.jcyt.2019.02.006DOI Listing
March 2019
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