444 results match your criteria The Role of Sentinal Node Biopsy in Skin Cancer


How we treat locoregional melanoma.

ESMO Open 2021 Apr 27;6(3):100136. Epub 2021 Apr 27.

Melanoma, Cancer Immunotherapy and Innovative Therapy Unit, Istituto Nazionale dei Tumori IRCCS Fondazione Pascale, Napoli, Italy. Electronic address:

Cutaneous melanoma is the most lethal form of skin cancer and its incidence has been increasing in the past 30 years. Although this is completely resectable in most cases, thicker melanoma and those with regional lymph-node involvement are at a high risk of relapse. In recent years, the management of locoregional disease has drastically changed. Read More

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T cell infiltration on local CpG-B delivery in early-stage melanoma is predominantly related to CLEC9ACD141 cDC1 and CD14 antigen-presenting cell recruitment.

J Immunother Cancer 2021 Mar;9(3)

Department of Medical Oncology, Amsterdam University Medical Centers, Vrije Universiteit, Cancer Center Amsterdam, Amsterdam, The Netherlands

Background: We previously reported CpG-B injection at the primary tumor excision site prior to re-excision and sentinel node biopsy to result in immune activation of the sentinel lymph node (SLN), increased melanoma-specific CD8 T cell rates in peripheral blood, and prolonged recurrence-free survival. Here, we assessed recruitment and activation of antigen-presenting cell (APC) subsets in the SLN and at the injection site in relation to T cell infiltration.

Methods: Re-excision skin specimens from patients with clinical stage I-II melanoma, collected 7 days after intradermal injection of either saline (n=10) or 8 mg CpG-B (CPG7909, n=12), were examined by immunohistochemistry, quantifying immune subsets in the epidermis, papillary, and reticular dermis. Read More

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Sentinel lymph node biopsy in head and neck cutaneous melanomas: A PRISMA-compliant systematic review and meta-analysis.

Medicine (Baltimore) 2021 Feb;100(5):e24284

Department of Aesthetic Plastic and Burn Surgery.

Background: Head and neck melanomas (HNMs) behave differently from cutaneous melanomas in other sites, and the efficacy of sentinel lymph node biopsy (SLNB) for patients with HNMs remains controversial.

Methods: Studies on prognosis following SLNB were included. The prognostic role of SLNB and other potential predictors were analyzed using pooled relative risk (RR) or hazard ratio (HR). Read More

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February 2021

[Predictive value of sentinel lymph node biopsy in prognosis of acral melanoma].

Zhonghua Zhong Liu Za Zhi 2021 Jan;43(1):147-154

Department of Ultrasound Diagnosis, Beijing Jishuitan Hospital, Peking University, Beijing 100035, China.

To explore the application of sentinel lymph node biopsy (SLNB) and its prognostic value in the treatment of acral melanoma. We retrospective analyzed 118 patients who underwent sentinel lymph node biopsy from Mar 2012 to Jun 2019 with effective follow-up data available in our institute. We ruled out palpable regional lymph node metastasis with preoperative imaging of MRI and ultrasonography, used the (99)Tc(m)-Dextran (Dx) as a tracer, with intraoperative γ-ray probe positioning for SLN capture. Read More

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January 2021

Merkel cell carcinoma.

Authors:
P Patel K Hussain

Clin Exp Dermatol 2020 Nov 30. Epub 2020 Nov 30.

Department of Dermatology, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.

Merkel cell carcinoma (MCC) of the skin is a rare, aggressive form of skin cancer that metastasizes to other parts of the body. This cutaneous neuroendocrine tumour mainly affects older people, with most cases generally occurring over the age of 50 years. Merkel cell polyomavirus has been shown to induce gene mutations resulting in this skin cancer, with immunosuppression and ultraviolet radiation being other key risk factors in its pathogenesis. Read More

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November 2020

Diagnosis and management of cutaneous melanoma.

Aust J Gen Pract 2020 11;49(11):733-739

MBBS, FRACS, Senior Surgeon, Melanoma Institute Australia, NSW; Emeritus Professor of Melanoma and Surgical Oncology, The University of Sydney, NSW.

Background: In the field of melanoma, clinical trials evaluating the impact of sentinel node biopsy, completion lymph node dissection and adjuvant medical therapies on patient outcomes have provided evidence that has changed practice significantly over the past five years.

Objective: The aim of this article is to discuss key evidence that has informed new Cancer Council Australia melanoma management guidelines.

Discussion: General practitioners play a critical role in melanoma diagnosis and follow-up. Read More

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November 2020

Expression of IMP3 in a retrospective cohort of melanomas with selective lymph node biopsy.

Dermatol Ther 2020 11 2;33(6):e14413. Epub 2020 Nov 2.

Department of Physical Therapy, Faculty of Health Sciences, Sport and Health Joint University Institute (iMUDS), University of Granada, Granada, Spain.

Insulin-like growth factor-II mRNA-binding protein 3 (IMP-3), which is a member of the insulin-like growth factor mRNA-binding protein family, is expressed at high levels in many types of cancer, where it plays an important role in cell proliferation, as well as in the processes of invasion, migration, and metastasis. Its expression has also been demonstrated in malignant melanoma, but not in other benign skin lesions, which has raised the possibility of using it as a predictive and prognosis marker. Its relationship with sentinel lymph node biopsy, however, has not been explored yet. Read More

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November 2020

Positron Emission Tomography in Merkel Cell Carcinoma.

Cancers (Basel) 2020 Oct 9;12(10). Epub 2020 Oct 9.

German Cancer Research Center, Clinical Cooperation Unit Nuclear Medicine, 69120 Heidelberg, Germany.

Merkel cell carcinoma (MCC) is a rare neuroendocrine skin malignancy usually arising as a nonspecific nodule on sun-exposed areas of the head and neck. Given the poor prognosis of this aggressive tumor, assessment of disease burden in pre- and post-treatment care may ensure an optimal management with significant implications for patient surveillance and prognosis. Although imaging has established its role in locally advanced or distant metastatic MCC, a standard imaging algorithm is yet to be determined and respective recommendations are mainly based on melanoma. Read More

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October 2020

Sentinel lymph node biopsy is associated with increased cost in higher risk thin melanoma.

J Surg Oncol 2021 Jan 16;123(1):104-109. Epub 2020 Sep 16.

Department of Surgery, University of Wisconsin Hospitals and Clinics, Madison, Wisconsin, USA.

Introduction: National Comprehensive Cancer Network guidelines recommend that sentinel lymph node biopsy (SLNB) be discussed with patients with thin melanoma at higher risk for lymph node metastasis (T1b or T1a with positive deep margins, lymphovascular invasion, or high mitotic index). We examined the association between SLNB and resource utilization in this cohort.

Methods: We conducted a retrospective cohort study of patients that underwent wide local excision for higher risk thin melanomas from 2009 to 2018 at a tertiary care center. Read More

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January 2021

Vascular Endothelial Growth Factor Receptor-3 Expression Predicts Sentinel Node Status in Primary Cutaneous Melanoma.

Acta Derm Venereol 2020 Aug 18;100(15):adv00235. Epub 2020 Aug 18.

Department of Dermatology, University Medical Center, Ruprecht-Karls-University Heidelberg, DE-69120 Heidelberg, Germany. E-mail:

This study analysed the expression of vascular endothelial growth factor-A (VEGF), VEGFR-2, and VEGFR-3 in primary cutaneous melanomas with positive and negative sentinel node status (SLN) (a total of 58 specimens divided into 2 groups of 29 for each status). The specimens were collected from the pathological archive of the department of Dermatology, Venereology and Allergology of the University Medical Center Heidelberg. A quantification score was developed for protein expression, by considering the percentage of positive melanoma cells (0: 0%, 1: up to 1%, 2: 2-10%, 3: 11-50%, and 4: > 50%) in relation to the intensity of staining (0: negative, 1: low, 2: medium, 3: strong). Read More

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ASO Author Reflections: Role of Sentinel Lymph Node Biopsy in T1b Melanoma.

Ann Surg Oncol 2020 Dec 11;27(13):5257-5258. Epub 2020 Jun 11.

Department of Surgery, Gastric and Mixed Tumor Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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December 2020

Australian general practitioners' attitudes and knowledge of sentinel lymph node biopsy in melanoma management.

Aust J Gen Pract 2020 06;49(6):355-362

MPH (Hons), PhD, Head of Cancer Epidemiology and Prevention Research Group, Sydney School of Public Health and Melanoma Institute Australia, University of Sydney, NSW; Professor of Cancer Epidemiology, Sydney Medical School, University of Sydney, NSW.

Background And Objectives: In Australia, the uptake of the sentinel lymph node biopsy (SLNB) appears low despite clinical practice guideline recommendations. The aim of this study was to describe the knowledge and attitudes of general practitioners (GPs) to SLNB.

Method: GPs were recruited at an annual conference and a skin cancer skills workshop, and using GP professional communications. Read More

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Speed rate (SR) as a new dynamic index of melanoma behavior.

Pigment Cell Melanoma Res 2020 09 11;33(5):709-718. Epub 2020 Jun 11.

Dermatologic Clinic, Department of Medicine and Aging Science, University G D'Annunzio Chieti-Pescara, Chieti, Italy.

Melanomas are skin tumors that show a variety of biological behavior. Some develop very fast and some other grow extremely slow, with metastasis appearing, eventually, many years after the diagnosis. The number of mitoses in primary melanoma has been related to a more aggressive tumor and may have a potential as predictive factor for cutaneous melanoma survival. Read More

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September 2020

Compounding Benefits of Sentinel Lymph Node Biopsy for Perineal Melanoma: A Population-Based Retrospective Cohort Analysis.

Ann Plast Surg 2020 05;84(5S Suppl 4):S257-S263

From the Division of Plastic and Reconstructive Surgery, Stanford University Medical Center, Stanford University, Palo Alto, CA.

Introduction: Sentinel lymph node biopsy (SLNB) in the treatment of melanoma is known to provide valuable prognostic information. However, there is no literature describing an overall or disease-specific survival (DDS) benefit of SLNB. In the perineum, melanoma is often more advanced at presentation with current treatment guidelines translated from nonanatomic specific melanoma. Read More

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Defining the Prognostic Role of MicroRNAs in Cutaneous Melanoma.

J Invest Dermatol 2020 11 8;140(11):2260-2267. Epub 2020 Apr 8.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Breslow thickness (BT) is the most important histopathologic factor for primary melanoma staging. BT determines the margins for wide local excision whether sentinel lymph node biopsy should be performed and subsequent melanoma staging, and patient management. The correct determination of a 0. Read More

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November 2020

[Malignant melanoma].

Pathologe 2020 May;41(3):281-292

Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland.

Malignant melanoma is an aggressive skin cancer that originates from cells of the melanocytic lineage and is associated with an invasive growth pattern and early spread. Besides endogenous risk factors such as fair skin type or genetic disposition for the formation of multiple nevi, exposure to ultraviolet light is the most important exogenous risk factor. Treatment of patients with primary tumors includes the complete excision of the primary lesion with appropriate safety margins and in patients with an increased risk of metastasis sentinel lymph node excision. Read More

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The role of integrins in melanoma: a review.

Int J Dermatol 2020 May 10;59(5):525-534. Epub 2020 Mar 10.

Department of Dermatology, Mayo Clinic, Rochester, MN, USA.

Integrins are the major family of cell adhesion receptors in humans and essential for a wide range of normal physiology, including formation and maintenance of tissue structure integrity, cell migration, proliferation, and differentiation. Integrins also play a prominent role in tumor growth and metastasis. Translational research has tried to define the contribution of integrins to the phenotypic aggressiveness of melanoma because such knowledge is clinically useful. Read More

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Completion lymph node dissection for merkel cell carcinoma.

Am J Surg 2020 10 15;220(4):982-986. Epub 2020 Feb 15.

Department of Otolaryngology - Head and Neck Surgery, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Background: Sentinel lymph node biopsy (SLNB) is widely used for Merkel cell carcinoma (MCC), however in SLNB positive MCC the role of completion lymph node dissection (CLND) with or without adjuvant radiation therapy is unclear.

Objective: Our goal was to determine the impact of CLND and adjuvant radiation therapy on survival in SLNB positive MCC.

Materials And Methods: We examined 447 patients with MCC with a positive SLNB in the National Cancer Data Base from 2012 to 2015. Read More

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October 2020

Thick melanomas without lymph node metastases: A forgotten group with poor prognosis.

Eur J Surg Oncol 2020 05 2;46(5):918-923. Epub 2019 Dec 2.

Department of Medical Oncology, University Medical Center Cancer Center Utrecht, Utrecht University, PO Box 85500 3508, GA, Utrecht, the Netherlands.

Introduction: Although adjuvant therapy is available for melanoma patients with sentinel lymph node (SLN) metastases (pN+), this is not the case for thick melanomas without SLN involvement (pN-).

Objectives: We assessed overall and relative survival (OS, RS) in patients with >4.0 mm Breslow thickness (BT) pN- and pN + melanomas and ≤4. Read More

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[Melanoma within tattoos: Two cases and a systematic literature review].

Ann Dermatol Venereol 2020 Apr 4;147(4):285-292. Epub 2019 Dec 4.

Service de dermatologie, hôpital Victor Dupouy, 69, rue du Lieutenant-Colonel Prud'hon, 95100 Argenteuil, France. Electronic address:

Background: There have been reports of malignant melanoma arising within tattoos. However, there is no clear relationship between tattoos and the development of cutaneous malignancies. We report two new cases of melanoma and provide a review of cases of melanoma reported in the medical literature. Read More

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Desmoplastic melanoma: The role of pure and mixed subtype in sentinel lymph node biopsy and survival.

Cancer Med 2020 01 5;9(2):671-677. Epub 2019 Dec 5.

Department of Pathology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.

Background: Desmoplastic melanoma (DM) is an uncommon type of melanoma. Two histological subtypes of DM can be distinguished: pure and mixed (PDM and MDM). We hypothesized that discrimination between these subtypes is associated with sentinel lymph node biopsy (SLNB) status and survival. Read More

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January 2020

[Malignant melanoma].

Hautarzt 2020 Jan;71(1):63-77

Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland.

Malignant melanoma is an aggressive skin cancer that originates from cells of the melanocytic lineage and is associated with an invasive growth pattern and early spread. Besides endogenous risk factors such as fair skin type or genetic disposition for the formation of multiple nevi, exposure to ultraviolet light is the most important exogenous risk factor. Treatment of patients with primary tumors includes the complete excision of the primary lesion with appropriate safety margins and in patients with an increased risk of metastasis sentinel lymph node excision. Read More

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January 2020

Approaches to Perineural, Lymphovascular, and Single-Cell Disease.

Dermatol Surg 2019 12;45 Suppl 2:S118-S128

Department of Dermatology, University of Pittsburgh, Pittsburgh, PA.

Background: Mohs micrographic surgeons should be adept in identifying and managing perineural invasion (PNI), lymphovascular invasion (LVI), and single-cell spread (SCS), features denoting high-risk behavior of basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (cSCC) and microcystic adnexal carcinoma (MAC).

Objective: The purpose of this article is to review the literature and guidelines regarding the diagnosis of PNI, LVI, and SCS in BCC, cSCC, and MAC and examine the role of advanced diagnostic studies, adjuvant therapy, and reconstructive techniques of these high-risk tumors.

Materials And Methods: We performed a literature search including the following terms: PNI, LVI, SCS, BCC, cSCC, keratinocyte carcinoma, MAC, sentinel lymph node biopsy, radiation, chemotherapy, and staging. Read More

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December 2019

Imaging of Merkel Cell Carcinoma: What Imaging Experts Should Know.

Radiographics 2019 Nov-Dec;39(7):2069-2084

From the Division of Nuclear Medicine, Department of Radiology (G.A., F.B.), and Division of Dermatology, Department of Medicine (T.A., K.L., P.N.), University of Washington, 1959 NE Pacific St, Box 356113, Seattle, WA 98195-6113; and Department of Radiology, Virginia Commonwealth University Health System, Richmond, Va (S.A.F.).

Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous neuroendocrine tumor with a higher mortality rate than melanoma. Approximately 40% of MCC patients have nodal or distant metastasis at initial presentation, and one-third of patients will develop distant metastatic disease over their clinical course. Although MCC is rare, its incidence has been steadily increasing. Read More

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Setting the stage: Contemporary staging of non-melanomatous skin cancer and implementation of the new American Joint Committee on cancer eighth edition staging manual.

Oral Oncol 2019 11 28;98:102-108. Epub 2019 Sep 28.

Department of Radiation Oncology, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria, Australia. Electronic address:

Non-melanomatous skin cancer (NMSC) generally refers to basal cell and squamous cell carcinoma of the skin. The majority of patients are curatively treated with simple excision. Only few present with locally advanced disease or have evidence of high-risk features, placing them at an elevated risk of relapse. Read More

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November 2019

Current role of sentinel lymph node biopsy in the management of cutaneous melanoma: A UK consensus statement.

J Plast Reconstr Aesthet Surg 2020 Jan 28;73(1):36-42. Epub 2019 Jun 28.

The Christie NHS Foundation Trust, United Kingdom.

Sentinel node biopsy (SNB) has been at the forefront of the surgical staging of melanoma patients for the past 15 years. The high accuracy of this prognostic staging procedure is now recognised in all international guidelines for melanoma. However during this period there have been a number of important changes in the management of melanoma, many occurring within the past five years. Read More

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January 2020

[Research progress of sentinel lymph node biopsy and regional dissection in melanoma].

Zhonghua Zhong Liu Za Zhi 2019 Jul;41(7):481-485

Department of Orthopedic Oncology Surgery, Beijing Ji Shui Tan Hospital, Peking University, Beijing 100035, China.

Melanoma is a malignant tumor derived from the skin and mucous membrane, the epidemiological data showed that the incidence of melanoma elevated rapidly in the last decade. Early lymph node metastasis is a distinguishing characteristic of melanoma. The assessment of regional lymph nodes is a vital factor for melanoma staging and comprehensive therapeutic strategies. Read More

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Skin Cancer: Squamous and Basal Cell Carcinomas.

FP Essent 2019 Jun;481:17-22

Approximately 1 in 5 Americans will develop skin cancer during their lifetime; 97% of these cancers will be nonmelanoma skin cancers (NMSCs). Basal cell carcinoma (BCC) comprises approximately 80% of NMSCs and most of the remainder are cutaneous squamous cell carcinomas (SCCs). The predominant risk factor for NMSC is exposure to solar UV radiation. Read More

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Recurrence after sentinel lymph node biopsy in cutaneous melanoma: a single-center experience in Slovak patients.

Neoplasma 2019 Jul 24;66(4):647-651. Epub 2019 Apr 24.

Department of Surgical Oncology, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovakia.

The standard approach in the management of cutaneous malignant melanoma is considered to be a complete excision of the primary lesion with an appropriate margin of the normal tissue according to Breslow thickness. Usually sentinel lymph node biopsy (SLNB) can help to determine the nodal status, and thus improve the accuracy of staging of the disease. However, the role of SLNB in melanoma treatment remains controversial. Read More

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