391 results match your criteria The Role of Sentinal Node Biopsy in Skin Cancer


Clinical Value of Single-photon Emission Computed Tomography Combined With Computed Tomography for Sentinel Lymph Node Identification in Melanoma.

Ann Plast Surg 2019 Apr;82(4S Suppl 3):S192-S194

From the Section of Plastic and Reconstructive Surgery, Department of Surgery, Yale New Haven Hospital, New Haven, CT.

Introduction: Melanoma is the deadliest form of skin cancer and has the ability to metastasize widely. Accurate diagnosis of sentinel lymph nodes (SLN) is crucial to its management. The gold standard for SLN identification is planar lymphoscintigraphy. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001895DOI Listing
April 2019
1 Read

Enhancing the prognostic role of melanoma sentinel lymph nodes through microscopic tumour burden characterization: clinical usefulness in patients who do not undergo complete lymph node dissection.

Melanoma Res 2019 04;29(2):163-171

Department of Plastic and Reconstructive Surgery, Regional Melanoma Referral Center and Melanoma & Skin Cancer Unit.

This study aimed to investigate the sentinel lymph node (SLN) tumour burden to predict the non-SLN positivity rate and the survival of melanoma patients to evaluate whether SLN microstaging could predict the prognosis, similar to what is currently performed by examining the lymph nodes excised by complete lymph node dissection. Of 1130 consecutive melanoma patients who underwent SLN biopsy, 226 were tumour-positive and 204 were included in this study. SLN metastases were classified on the basis of dimensional (Rotterdam) and topographic (Dewar) criteria either separately or combined. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000481DOI Listing
April 2019
1 Read

Utilization of Indocyanine Green to Aid in Identifying Sentinel Lymph Nodes in Merkel Cell Cancer.

J Surg Res 2018 Dec 18;232:365-368. Epub 2018 Jul 18.

Cleveland Clinic Foundation, Department of Plastic Surgery, Cleveland, Ohio. Electronic address:

Background: Merkel cell carcinoma (MCC) is a relatively rare skin cancer with high rates of regional lymph node involvement and metastatic spread. National Comprehensive Cancer Network guidelines recommend sentinel lymph node biopsy (SLNB) for staging purposes. The goal of this study is to report our experience utilizing indocyanine green (ICG) fluorescence-based technology to aid in SLNB detection in MCC. Read More

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http://dx.doi.org/10.1016/j.jss.2018.06.070DOI Listing
December 2018
1 Read

The Role of Sentinel Lymph Node Biopsy in the Management of Cutaneous Malignancies.

Facial Plast Surg Clin North Am 2019 Feb;27(1):119-129

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1445, Houston, TX 77030-4009, USA. Electronic address:

Sentinel lymph node biopsy uses the concept of selective lymphatic drainage and the lymphatic microvasculature to identify first-echelon nodes draining a given malignancy. Although initially considered difficult and unreliable in the head and neck, experience with the technique has improved and evolved significantly over the last 3 decades. It is now recognized to be accurate and reliable for regional nodal staging and detection of occult nodal metastasis in the head and neck. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10647406183006
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http://dx.doi.org/10.1016/j.fsc.2018.08.004DOI Listing
February 2019
8 Reads

Guidelines of care for the management of primary cutaneous melanoma.

J Am Acad Dermatol 2019 01 1;80(1):208-250. Epub 2018 Nov 1.

American Academy of Dermatology, Rosemont, Illinois.

The incidence of primary cutaneous melanoma continues to increase each year. Melanoma accounts for the majority of skin cancer-related deaths, but treatment is usually curative following early detection of disease. In this American Academy of Dermatology clinical practice guideline, updated treatment recommendations are provided for patients with primary cutaneous melanoma (American Joint Committee on Cancer stages 0-IIC and pathologic stage III by virtue of a positive sentinel lymph node biopsy). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183258
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http://dx.doi.org/10.1016/j.jaad.2018.08.055DOI Listing
January 2019
15 Reads

Complete lymph node dissection or observation in melanoma patients with multiple positive sentinel lymph nodes: A single-center retrospective analysis.

J Dermatol 2018 Oct 10;45(10):1191-1194. Epub 2018 Aug 10.

Department of Dermatology and Venereology, University of Cologne, Cologne, Germany.

Although the role of sentinel lymph node biopsy (SLNB) as a prognostic factor is well established, its consequences for therapy are controversial. The aim of this study was to analyze if complete lymph node dissection (CLND) in patients with more than one positive sentinel lymph node (SLN) significantly improves melanoma-specific survival (MSS) and progression-free survival (PFS). Medical records of patients who underwent SLNB between 2001 and 2016 at the University Hospital of Cologne were reviewed, and patients with positive SLN were identified. Read More

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http://doi.wiley.com/10.1111/1346-8138.14577
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http://dx.doi.org/10.1111/1346-8138.14577DOI Listing
October 2018
11 Reads

Factors Affecting Dermatologists' Use of a 31-Gene Expression Profiling Test as an Adjunct for Predicting Metastatic Risk in Cutaneous Melanoma.

J Drugs Dermatol 2018 May;17(5):544-547

Importance: A 31-gene expression profile (31-GEP) test to predict metastatic risk in patients with cutaneous malignant melanoma has previously been validated and is available for clinical use. The impact of the availability of such a test on clinical decision-making has previously been studied. However, little is known about which factors play a role in clinicians' decision to utilize the test. Read More

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May 2018
6 Reads

Regression and Sentinel Lymph Node Status in Melanoma Progression.

Med Sci Monit 2018 Mar 6;24:1359-1365. Epub 2018 Mar 6.

Department of Dermatology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

BACKGROUND The purpose of this study was to assess the role of regression and other clinical and histological features for the prognosis and the progression of cutaneous melanoma. MATERIAL AND METHODS Between 2005 and 2016, 403 patients with melanoma were treated and followed at our Department of Dermatology. Of the 403 patients, 173 patients had cutaneous melanoma and underwent sentinel lymph node (SLN) biopsy and thus were included in this study. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848716PMC
March 2018
7 Reads

Cutaneous squamous cell carcinoma and the emerging role of sentinel lymph node biopsy.

G Ital Dermatol Venereol 2018 Jun 26;153(3):403-418. Epub 2018 Feb 26.

Department of Dermatology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile -

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and is usually associated with a favorable prognosis in most patients. However, a small minority of patients will be diagnosed with a high-risk cSCC (HRcSCC) and a proportion will have a poor outcome, in some cases causing death. HRcSCC is characterized by an increase in aggressiveness manifested as local recurrence, the development of lymph node metastases, and occasionally death. Read More

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http://dx.doi.org/10.23736/S0392-0488.18.05936-9DOI Listing
June 2018
7 Reads

Impact of Gene Expression Profiling on Decision-Making in Clinically Node Negative Melanoma Patients after Surgical Staging.

J Drugs Dermatol 2018 Feb;17(2):196-199

Introduction: The surgeon's role in the follow-up of pathologic stage I and II melanoma patients has traditionally been minimal. Melanoma genetic expression profile (GEP) testing provides binary risk assessment (Class 1-low risk, Class 2-high risk), which can assist in predicting metastasis and formulating appropriate follow up. We sought to determine the impact of GEP results on the management of clinically node negative cutaneous melanoma patients staged with sentinel lymph node biopsy (SLNB). Read More

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February 2018
9 Reads

Performance of a prognostic 31-gene expression profile in an independent cohort of 523 cutaneous melanoma patients.

BMC Cancer 2018 02 5;18(1):130. Epub 2018 Feb 5.

Skin Cancer Institute, Northwestern University, Lurie Comprehensive Cancer Center, 420 East Superior Street, Chicago, IL, 60611, USA.

Background: The heterogeneous behavior of patients with melanoma makes prognostication challenging. To address this, a gene expression profile (GEP) test to predict metastatic risk was previously developed. This study evaluates the GEP's prognostic accuracy in an independent cohort of cutaneous melanoma patients. Read More

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http://dx.doi.org/10.1186/s12885-018-4016-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800282PMC
February 2018
21 Reads

Cutaneous squamous cell carcinoma: Management of advanced and high-stage tumors.

J Am Acad Dermatol 2018 02;78(2):249-261

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

While the majority of cutaneous squamous cell carcinomas (cSCCs) can be treated surgically, the additional work-up and treatments indicated for high-risk cSCC remain undefined. In recent years, improvements in tumor staging systems have allowed for the more accurate stratification of tumors into high- and low-risk categories. This insight, along with the publication of cSCC guidelines, brings us closer to the development of a consensus approach. Read More

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http://dx.doi.org/10.1016/j.jaad.2017.08.058DOI Listing
February 2018
5 Reads

T regulatory cells mediate immunosuppresion by adenosine in peripheral blood, sentinel lymph node and TILs from melanoma patients.

Cancer Lett 2018 03 3;417:124-130. Epub 2018 Jan 3.

Plastic and Reconstructive Surgery Unit - Regional Melanoma Referral Center and Melanoma & Skin Cancer Unit, Tuscan Tumour Institute (ITT) - Santa Maria Annunziata Hospital, Florence, Italy.

T regulatory cells (Tregs), involved in tumour tolerance, can generate Adenosine by CD39/CD73 surface enzymes, which identify four Tregs subsets: CD39CD73 nTregs, CD39CD73 iTregs, CD39CD73 oTregs and CD39CD73 xTregs. In melanoma patients, increased Tregs levels are detected in peripheral blood (PB), sentinel lymph node (SLN) and tumour infiltrating lymphocytes (TILs), but Adenosine role was not investigated yet. We examined total Tregs and Adenosine subsets in PB, SLN and TILs from melanoma patients (n = 32) and PB from healthy donors (HD; n = 10) by flow cytometry. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043835183000
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http://dx.doi.org/10.1016/j.canlet.2017.12.032DOI Listing
March 2018
4 Reads

Interaction between Merkel cell carcinoma and the immune system: Pathogenetic and therapeutic implications.

Mol Clin Oncol 2017 Nov 1;7(5):729-732. Epub 2017 Sep 1.

Unit of Dermatology, University of Padua, I-35128 Padua, Italy.

Merkel cell carcinoma (MCC) is a rare, aggressive primary cutaneous neuroendocrine carcinoma. It usually appears on the face and neck of elderly Caucasian people as a flesh-colored, erythematous or violaceous dome-shaped, non-tender nodule with a smooth surface. In immunocompromised patients with T-cell dysfunction, such as patients with acquired immunodeficiency syndrome (AIDS) or solid organ transplant recipients, the incidence of this disease is markedly increased. Read More

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http://dx.doi.org/10.3892/mco.2017.1406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666639PMC
November 2017
4 Reads

Modern Approaches to the Surgical Management of Malignant Breast Disease: The Role of Breast Conservation, Complete Mastectomy, Skin- and Nipple-Sparing Mastectomy.

Clin Plast Surg 2018 Jan 5;45(1):1-11. Epub 2017 Oct 5.

Breast Surgical Oncology, University of Toronto, Princess Margaret Cancer Centre, University Health Network, Room 3-130, 610 University Avenue, Toronto, Ontario M5G2M9, Canada.

The armamentarium of the modern breast surgeon includes the time-tested procedures of modified radical mastectomy and lumpectomy with sentinel lymph node biopsy with postoperative radiation, but has evolved to include several options that produce excellent oncologic endpoints and improved cosmesis. These options include skin- and nipple-sparing mastectomies with immediate reconstruction as well as oncoplastic procedures that allow larger excisions and better postoperative breast shape. This article provides an overview of these modern surgical approaches for breast cancer treatment. Read More

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http://dx.doi.org/10.1016/j.cps.2017.07.002DOI Listing
January 2018
5 Reads

Health-related quality of life in melanoma patients: Impact of melanoma-related limb lymphoedema.

Eur J Cancer 2017 11 15;85:122-132. Epub 2017 Sep 15.

Department of Plastic Surgery, Herlev and Gentofte Hospital, University of Copenhagen, Denmark.

Aim: To explore health-related quality of life (HRQoL) in recurrence-free melanoma patients, with a focus on the association between melanoma-related limb lymphoedema and HRQoL.

Methods: HRQoL was evaluated using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), the breast cancer module (EORTC QLQ-BR23) subscales body image and future perspective, the Functional Assessment for Cancer Therapy-General subscale social/family well-being and the Hospital Anxiety and Depression Scale. Data were analysed using linear and ordinal logistic regression adjusting for age and gender. Read More

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http://dx.doi.org/10.1016/j.ejca.2017.07.052DOI Listing
November 2017
5 Reads

High Antigen Processing Machinery component expression in Langerhans cells from melanoma patients' sentinel lymph nodes.

Cell Immunol 2017 Oct 30;320:29-37. Epub 2017 Aug 30.

Plastic and Reconstructive Surgery Unit, Regional Melanoma Referral Center and Melanoma & Skin Cancer Unit, Tuscan Tumour Institute (ITT) - S.M. Annunziata Hospital, Florence, Italy.

Langerhans cells (LCs) from melanoma patients sentinel lymph nodes (SLN) are poor T cell activators mostly due to an immature immunophenotype. However Antigen Presenting Machinery (APM) role is unknown. We investigated HLA-class I APM components (Delta, LMP-7/10, TAP-1, Calnexin, Tapasin, β2-microglobulin and HLA-A,B,C) in LCs from healthy donors skin and melanoma patients SLN. Read More

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http://dx.doi.org/10.1016/j.cellimm.2017.08.007DOI Listing
October 2017
14 Reads

Starting a sentinel node service for melanoma: Is there a role for predictive nomograms?

J Plast Reconstr Aesthet Surg 2017 12 16;70(12):1789-1790. Epub 2017 Aug 16.

The Welsh Centre of Burns and Plastic Surgery, Morriston Hospital, Swansea, SA6 6NL, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S17486815173032
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http://dx.doi.org/10.1016/j.bjps.2017.08.003DOI Listing
December 2017
17 Reads

Aggressive digital papillary adenocarcinoma: treatment with Mohs micrographic surgery and an update of the literature.

Int J Dermatol 2017 Oct 21;56(10):1061-1064. Epub 2017 Aug 21.

Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA.

Background: Aggressive digital papillary adenocarcinoma (ADPA) is a rare adenocarcinoma of the sweat glands.

Aims: We wish to report the treatment of two cases of ADPA with Mohs micrographic surgery and review the presentation, management, and prognosis of this rare malignancy.

Materials & Methods: Cases of ADPA were identified from recent surgery logs. Read More

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http://dx.doi.org/10.1111/ijd.13712DOI Listing
October 2017
28 Reads

Tumour mutation status and sites of metastasis in patients with cutaneous melanoma.

Br J Cancer 2017 Sep 8;117(7):1026-1035. Epub 2017 Aug 8.

Victorian Melanoma Service, Alfred Hospital, Melbourne, Victoria 3004, Australia.

Background: Cutaneous melanoma can metastasise haematogenously and/or lymphogenously to form satellite/in-transit, lymph node or distant metastasis. This study aimed to determine if BRAF and NRAS mutant and wild-type tumours differ in their site of first tumour metastasis and anatomical metastatic pathway.

Methods: Prospective cohort of patients with a histologically confirmed primary cutaneous melanoma at three tertiary referral centres in Melbourne, Australia from 2010 to 2015. Read More

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http://dx.doi.org/10.1038/bjc.2017.254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625668PMC
September 2017
11 Reads

Multiple Lymph Node Basin Drainage in Trunk Melanoma Is Not Associated with Survival of Sentinel Lymph Node-Positive Patients.

Dermatology 2017 25;233(2-3):205-211. Epub 2017 Jul 25.

Dermatologic Clinic, Medical Sciences Department, University of Turin, Turin, Italy.

Objectives: This study was aimed at investigating the prognostic role of multiple lymph node basin drainage (MLBD) in patients with positive sentinel lymph node (SLN) biopsy.

Background: MLBD is frequently observed in patients with trunk melanoma undergoing SLN. The prognostic value of MLBD in SLN-positive patients is still debated. Read More

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http://dx.doi.org/10.1159/000477457DOI Listing
July 2018
47 Reads

Surgical Management of Periocular Cancers: High- and Low-Risk Features Drive Treatment.

Authors:
Richard C Allen

Curr Oncol Rep 2017 Sep;19(9):57

Section of Ophthalmology, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1445, Houston, TX, 77030, USA.

Purpose Of Review: Recent advances in the treatment of eyelid tumors have centered on the excision, evaluation of margins, role of sentinel lymph node biopsy, and adjunctive/adjuvant systemic and radiation therapy. The purpose of this review is to elaborate on these advances.

Recent Findings: Mohs excision of basal cell carcinoma and squamous cell carcinoma continues to provide the greatest success in complete excision of the cancer, especially in those cases of high-risk disease including medial canthal location and recurrent disease. Read More

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http://dx.doi.org/10.1007/s11912-017-0618-1DOI Listing
September 2017
6 Reads

Role of sentinel lymph node biopsy as a staging procedure in patients with melanoma: A critical appraisal.

Australas J Dermatol 2017 Nov 14;58(4):268-273. Epub 2017 Jul 14.

Melanoma Institute Australia, University of Sydney, Sydney, New South Wales, Australia.

Worldwide, sentinel node (SN) biopsy for accurate staging is now part of the standard work-up of patients with melanomas ≥1.0 mm Breslow thickness, as it is for staging patients with breast cancer. Nuclear medicine imaging and surgical techniques have evolved to such a degree that a SN can be identified and removed in virtually every patient. Read More

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http://dx.doi.org/10.1111/ajd.12655DOI Listing
November 2017

High-risk squamous cell carcinoma of the ear - A potential role for sentinel node biopsy.

Head Neck 2017 09 22;39(9):1840-1844. Epub 2017 Jun 22.

Department of Plastic and Reconstructive Surgery, University College Hospital, Galway, National University of Ireland, Galway.

Background: Squamous cell carcinomas (SCCs) of the external ear have a significant rate of metastasis. The purpose of this study was to present analyzed factors associated with auricular SCC metastasis in order to identify a group that may benefit from sentinel lymph node biopsy (SLNB).

Methods: We performed a retrospective review of all operable SCCs between 2009 and 2014. Read More

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http://dx.doi.org/10.1002/hed.24843DOI Listing
September 2017
6 Reads

Melanoma patient imaging in the era of effective systemic therapies.

Eur J Surg Oncol 2017 Aug 25;43(8):1517-1527. Epub 2017 May 25.

Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia; Discipline of Surgery, The University of Sydney, Sydney, NSW, Australia; Division of Surgery, Royal Prince Alfred Hospital, Camperdown, NSW, Australia. Electronic address:

Imaging plays a critical role in the current multi-disciplinary management of patients with melanoma. It is used for primary disease staging, surgical planning, and surveillance in high-risk patients, and for monitoring the effects of systemic or loco-regional therapies. Several different imaging modalities have been utilised in the past. Read More

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http://dx.doi.org/10.1016/j.ejso.2017.05.014DOI Listing
August 2017
9 Reads

Anatomy of the cutaneous lymphatic system of the trunk: a clinico-anatomical study of 90 cutaneous melanomas.

Surg Radiol Anat 2018 Jan 29;40(1):3-13. Epub 2017 May 29.

Rouen University, Rouen Cedex 1, France.

Purpose: The cutaneous lymphatic system of the trunk is a complex network, the anatomical knowledge of which remains unclear. The lymphatic system plays a major role in the dissemination of lymphophilic cancers like melanomas. The aim of this study was to improve our knowledge, optimize the care of patients with cutaneous tumors of the trunk, and to use our clinical experience of the topography of pathologic lymph nodes related to cutaneous melanomas and depicted by lymphoscintigraphy. Read More

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http://dx.doi.org/10.1007/s00276-017-1877-0DOI Listing
January 2018
5 Reads

[Surgery plays a key role in the treatment].

Lakartidningen 2017 05 9;114. Epub 2017 May 9.

Sahlgrenska universitetssjukhuset - Kirurgi Goteborg, Sweden Sahlgrenska universitetssjukhuset - Kirurgi Goteborg, Sweden.

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May 2017
4 Reads

What's New in Eyelid Tumors.

Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):143-152

Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, NY.

Eyelid malignancies represent between 5% and 10% of all skin cancers. Basal cell carcinoma is the most common, followed by squamous cell carcinoma, sebaceous cell carcinoma, Merkel cell carcinoma, and melanoma. The gold standard treatment for periocular epithelial malignancies is surgical excision. Read More

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http://dx.doi.org/10.22608/APO.201701DOI Listing
September 2017
9 Reads

Neuropathic pain and quality of life after wide local excision and sentinel lymph node biopsy for melanoma: a multicentre study.

Melanoma Res 2017 04;27(2):121-125

aDepartment of Plastic Surgery, Norfolk and Norwich University Hospital, NorwichbDepartment of Plastic Surgery, Oxford University Hospitals NHS Foundation Trust, OxfordcDepartment of Plastic Surgery, Leeds Teaching Hospitals NHS Trust, LeedsdSchool of Medicine, Centre for Medical Education, Cardiff University, Cardiff, UK.

Wide local excision and sentinel lymph node biopsy is the mainstay of treatment for patients with melanoma. As survival outcomes improve, longer term quality of life questions become more pertinent and this study aims to assess the factors which may play a role following surgery. A total of, 221 patients who underwent wide local excision and sentinel lymph node biopsy for melanoma (AJCC stage I and II) were recruited from three UK centres. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000321DOI Listing
April 2017
4 Reads

Investigating the role of SPECT/CT in dynamic sentinel lymph node biopsy for penile cancers.

Eur J Nucl Med Mol Imaging 2017 Jul 7;44(7):1176-1184. Epub 2017 Feb 7.

Department of Nuclear Medicine, University College Hospitals London, London, UK.

Purpose: Currently, most centres use 2-D planar lymphoscintigraphy when performing dynamic sentinel lymph node biopsy in penile cancer patients with clinically impalpable inguinal nodes. This study aimed to investigate the role of SPECT/CT following 2-D planar lymphoscintigraphy (dynamic and static) in the detection and localization of sentinel lymph nodes in the groin.

Methods: A qualitative (visual) review was performed on planar followed by SPECT/CT lymphoscintigraphy in 115 consecutive patients (age 28-86 years) who underwent injection of Tc-nanocolloid followed by immediate acquisition of dynamic (20 min) and early static scans (5 min) initially and further delayed static (5 min) images at 120 min followed by SPECT/CT imaging. Read More

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http://dx.doi.org/10.1007/s00259-017-3636-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434125PMC
July 2017
19 Reads

Analysis of sentinel node positivity in primary cutaneous melanoma: an 8-year single institution experience.

Ir J Med Sci 2017 Nov 28;186(4):847-853. Epub 2017 Jan 28.

Department of Plastic and Reconstructive Surgery, Galway University Hospital, Galway, Ireland.

Background: Sentinel lymph node biopsy (SLNB) is a standard method for determining the pathologic status of the regional lymph nodes.

Aims: The aim of our study was to determine the incidence and clinicopathologic factors predictive of SLN positivity, and to evaluate the prognostic importance of SLNB in patients with cutaneous melanoma.

Methods: We performed a retrospective analysis of a prospectively maintained database of all patients who underwent SLNB for primary melanoma at our institution from 2005 to 2012. Read More

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http://dx.doi.org/10.1007/s11845-017-1559-2DOI Listing
November 2017
1 Read

Contemporary Management of Early-Stage Melanoma: A Systematic Review.

JAMA Facial Plast Surg 2017 May;19(3):232-238

Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor.

Importance: The incidence of melanoma is increasing, with 76 380 new cases of invasive melanoma and 68 480 new cases of melanoma in situ expected in 2016.

Objective: To review the contemporary management of early-stage melanoma.

Evidence Review: We searched PubMed, MEDLINE, and the Cochrane Database of Systematic Reviews databases from January 1, 2011, to May 1, 2016, yielding 966 articles. Read More

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http://dx.doi.org/10.1001/jamafacial.2016.1846DOI Listing
May 2017
9 Reads

[Care of Merkel cell carcinoma and role of the radiotherapy].

Bull Cancer 2017 Jan 15;104(1):101-108. Epub 2016 Dec 15.

Institut de cancérologie Lucien-Neuwirth, département de radiothérapie, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest en Jarez, France; Laboratoire de radiobiologie cellulaire et moléculaire de Lyon Sud, CNRS UMR 5822, 165, chemin du Grand-Revoyet, BP 12, 69921 Oullins cedex, France. Electronic address:

Merkel cell carcinoma is a rare neuro-endocrine tumor of skin with a poor prognosis. Data available in literature are scarce. Current treatment for locoregional disease is based on combined treatment by surgery and radiotherapy. Read More

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http://dx.doi.org/10.1016/j.bulcan.2016.10.023DOI Listing
January 2017
13 Reads

Spitz Nevi and Other Spitzoid Neoplasms in Children: Overview of Incidence Data and Diagnostic Criteria.

Pediatr Dermatol 2017 Jan 22;34(1):25-32. Epub 2016 Nov 22.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Spitz nevi are benign melanocytic neoplasms characterized by epithelioid or spindle melanocytes or both. In some rare cases their presentation overlaps with the clinical and histopathologic features of malignant melanoma, so a differential diagnosis can be difficult to make. Intermediate forms between Spitz nevi and malignant melanoma, with unpredictable behavior, have been called atypical Spitz tumors. Read More

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http://doi.wiley.com/10.1111/pde.13025
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http://dx.doi.org/10.1111/pde.13025DOI Listing
January 2017
7 Reads

Neck dissections: emerging role of oral pathologists.

J Exp Ther Oncol 2016 Nov;11(4):275-284

Keshlata Cancer Institute, Bareilly, 243001, Uttar Pradesh, India.

Background: Surgical resection has been the principle treatment approach for early lesions as well as advanced stage carcinomas of upper aero digestive tract. Neck dissection is the primary treatment given to nodal metastasis of oral carcinomas. Choice of irradiation and chemotherapy post surgery relies heavily on the histopathological assessment of surgical margins of resected tumor, dissected lymph nodes and accessory tissues. Read More

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November 2016
10 Reads

Head and neck melanoma (excluding ocular melanoma): United Kingdom National Multidisciplinary Guidelines.

Authors:
O A Ahmed C Kelly

J Laryngol Otol 2016 May;130(S2):S133-S141

Northern Centre for Cancer Care and Newcastle University, Freeman Hospital,Newcastle upon Tyne,UK.

This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the United Kingdom. This paper provides consensus recommendations on the management of melanomas arising in the skin and mucosa of the head and neck region on the basis of current evidence. Recommendations • At-risk individuals should be warned about the correlation between ultraviolet radiation (UVR) exposure and skin cancer, and should be given advice on UVR protection. Read More

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http://www.journals.cambridge.org/abstract_S0022215116000852
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http://dx.doi.org/10.1017/S0022215116000852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873897PMC
May 2016
10 Reads

Adjuvant ipilimumab in stage III melanoma: New landscape, new questions.

Eur J Cancer 2016 12 4;69:39-42. Epub 2016 Nov 4.

Gustave Roussy Cancer Campus Grand Paris, Villejuif, France; Universite Paris-Sud, Kremlin-Bicêtre, France. Electronic address:

The recently reported significant prolongation of overall survival with ipilimumab as adjuvant in high-risk stage III melanoma patients represents an important event in the adjuvant treatment landscape. The European Organisation for Research and Treatment of Cancer 18071 trial demonstrated a 28% reduction in risk of death in patients treated with ipilimumab at 10 mg/kg (hazard ratio for death, 0.72; 95. Read More

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http://dx.doi.org/10.1016/j.ejca.2016.10.009DOI Listing
December 2016
12 Reads

The role of FDG-PET/CT in preoperative staging of sentinel lymph node biopsy-positive melanoma patients.

EJNMMI Res 2016 Dec 5;6(1):73. Epub 2016 Oct 5.

Department of Nuclear Medicine, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark.

Background: On April 1, 2015, Odense University Hospital (OUH) began a new diagnostic strategy, wherein all malignant melanoma (MM) patients in the Region of Southern Denmark with a positive sentinel lymph node biopsy (SLNB) underwent FDG-PET/CT preoperatively prior to lymph node dissection (LND). The purpose of this study is to determine FDG-PET/CT's efficacy in finding distant metastasis in the first year after the implementation of this new strategy, and to what extent these findings influence subsequent diagnostic testing and treatment in this patient group. We conducted a retrospective multicenter cohort study which included all patients with MM from all hospitals in the Region of Southern Denmark from April 1, 2015 to April 1, 2016 found to be SLNB-positive who subsequently underwent FDG-PET/CT. Read More

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http://ejnmmires.springeropen.com/articles/10.1186/s13550-01
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http://dx.doi.org/10.1186/s13550-016-0228-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052236PMC
December 2016
2 Reads

Effects of time interval between primary melanoma excision and sentinel node biopsy on positivity rate and survival.

Eur J Cancer 2016 11 24;67:164-173. Epub 2016 Sep 24.

Department of Surgical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. Electronic address:

Background: Sentinel node biopsy (SNB) is essential for adequate melanoma staging. Most melanoma guidelines advocate to perform wide local excision and SNB as soon as possible, causing time pressure.

Objective: To investigate the role of time interval between melanoma diagnosis and SNB on sentinel node (SN) positivity and survival. Read More

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http://dx.doi.org/10.1016/j.ejca.2016.08.014DOI Listing
November 2016
50 Reads

A Case of Vanishing Brain Metastasis in a Melanoma Patient on Nivolumab.

Anticancer Res 2016 09;36(9):4795-8

Department of Hematology Oncology, SUNY Upstate University, Syracuse, NY, U.S.A.

Background: Melanoma is among the top three cancers to present with brain metastasis. The risk of brain metastases in advanced melanoma increases with disease duration. Cytotoxic chemotherapy does not have a significant role in the management of melanoma patients with brain metastases, neither alone nor in conjunction with radiation therapy. Read More

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http://ar.iiarjournals.org/content/36/9/4795.abstract
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http://dx.doi.org/10.21873/anticanres.11038DOI Listing
September 2016
8 Reads

Sentinel node biopsy in melanoma: Current controversies addressed.

Eur J Surg Oncol 2017 Mar 24;43(3):517-533. Epub 2016 Aug 24.

From the Department of Surgical Oncology at the Netherlands Cancer Institute - Antoni van Leeuwenhoek, Plesmanlaan 121, NL-1066 CX Amsterdam, The Netherlands. Electronic address:

Sentinel node biopsy (SNB) is the most accurate staging tool for melanoma patients. The procedure is indicated especially for intermediate thickness melanoma (pT2/3). SNB can be of value in thin melanoma (>0. Read More

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http://dx.doi.org/10.1016/j.ejso.2016.08.007DOI Listing
March 2017
5 Reads

A Comprehensive Approach to Pediatric Atypical Melanocytic Neoplasms with Comment on the Role of Sentinel Lymph Node Biopsy.

Crit Rev Oncog 2016 ;21(1-2):25-36

Moffitt Cancer Center and University of South Florida Morsani College of Medicine, Tampa, Florida.

Pediatric melanoma has been rising in incidence in recent years and its management poses challenges that are frequently exacerbated by diagnostic uncertainty about the benign or malignant nature of many pediatric melanocytic neoplasms. Sentinel lymph node biopsy (SLNB), originally described by Dr. Donald L. Read More

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http://www.dl.begellhouse.com/journals/439f422d0783386a,3930
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http://dx.doi.org/10.1615/CritRevOncog.2016016109DOI Listing
October 2017
14 Reads

Population-Based Analysis of Completion Lymphadenectomy in Intermediate-Thickness Melanoma.

Ann Surg Oncol 2017 Jan 27;24(1):127-134. Epub 2016 Jul 27.

Division of Surgical Oncology, East Carolina University Brody School of Medicine, Greenville, NC, USA.

Background: Multicenter selective lymphadenectomy trial 1 (MSLT-I) defined the prognostic and potential therapeutic values of sentinel lymph node biopsy (SLNB) for intermediate-thickness melanoma. The role of completion lymphadenectomy (CLND) is, however, unclear and the subject of the ongoing MSLT-II trial.

Methods: From 2003 to 2012, patients with tumors 1-4 mm thick with positive SLNB were identified in the Surveillance Epidemiology and End Results Program registry. Read More

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http://dx.doi.org/10.1245/s10434-016-5460-4DOI Listing
January 2017
2 Reads

Sentinel lymph node status affects long-term survival in patients with intermediate-thickness melanoma.

J Cancer Res Ther 2016 Apr-Jun;12(2):840-4

Department of Surgery, Ankara Oncology Training and Research Hospital, Ankara, Turkey.

Objective: The aim of this study was to examine the role of sentinel lymph node biopsy (SLNB) on long-term disease outcome in patients with intermediate-thickness primary cutaneous melanomas.

Materials And Methods: Forty patients with intermediate-thickness melanomas, defined as 1.0-4. Read More

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http://dx.doi.org/10.4103/0973-1482.186694DOI Listing
March 2017
6 Reads

Sentinel Lymph Node Biopsy for Cutaneous Squamous Cell Carcinoma on the Head and Neck.

JAMA Otolaryngol Head Neck Surg 2016 12;142(12):1171-1176

Department of Otolaryngology, University of Michigan Medical School and Comprehensive Cancer Center, Ann Arbor.

Importance: Metastasis of cutaneous squamous cell carcinoma (SCC) to the nodal basin is associated with a poor prognosis. The role of sentinel lymph node biopsy (SLNB) for regional staging in patients diagnosed with SCC is unclear.

Objective: To evaluate a single institution's experience with use of SLNB for regional staging of SCC on the head and neck. Read More

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http://dx.doi.org/10.1001/jamaoto.2016.1927DOI Listing
December 2016
12 Reads

Results of Sentinel Lymph Node Biopsy in Patients with Breast Cancer in 10-Year Own Material of the 4th Military Teaching Hospital with Polyclinic in Wrocław.

Pol Przegl Chir 2016 May;88(3):130-5

Unlabelled: At present, sentinel lymph node biopsy is a standard procedure to assess the advancement of breast cancer and cutaneous melanoma. The aim of the study was to assess the role of the sentinel lymph node biopsy in the treatment of patients with breast cancer in our own material.

Material And Methods: Analyzed was medical documentation of 258 patients with initially operable breast cancer, qualified for operation with sentinel lymph node biopsy in 2004-2014 in the Department of Surgery of the 4th Military Teaching Hospital. Read More

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http://dx.doi.org/10.1515/pjs-2016-0040DOI Listing
May 2016
18 Reads

Pediatric and Adolescent Melanoma: A National Cancer Data Base Update.

Ann Surg Oncol 2016 11 30;23(12):4058-4066. Epub 2016 Jun 30.

Department of Surgery, Carolinas Medical Center, Levine Cancer Institute, Charlotte, NC, USA.

Background: Studies suggest that the biology of pediatric and adolescent melanoma differs from that of adult disease. We report the largest series to date examining the natural history of pediatric and adolescent melanoma. We aim to elucidate the natural history of pediatric and adolescent melanoma and to examine the appropriateness of diagnostic and therapeutic modalities developed for adults and that are currently being used in children. Read More

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http://dx.doi.org/10.1245/s10434-016-5349-2DOI Listing
November 2016
9 Reads

Prognostic role of sentinel lymph node biopsy for patients with cutaneous melanoma: A retrospective study of surveillance, epidemiology, and end-result population-based data.

Oncotarget 2016 Jul;7(29):45671-45677

Department of Gastric Cancer and Soft Tissue Sarcomas, Fudan University Shanghai Cancer Center, and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.

Sentinel lymph node biopsy (SLNB) is a sensitive operation for finding micro-metastasis in patients with cutaneous melanoma without evidence of clinically positive lymph node findings. However, until now, no clinical trials or retrospective studies with large samples have been performed to investigate the clinical role of SLNB for cutaneous melanoma patients. In this study, we used the data of cutaneous melanoma from the Surveillance, Epidemiology, and End Results (SEER) database to compare overall survival (OS) and melanoma-specific survival (MSS) outcomes with clinical lymph node and SLN status. Read More

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http://dx.doi.org/10.18632/oncotarget.10140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216751PMC
July 2016
9 Reads

Sentinel lymph node biopsy in cutaneous melanoma.

G Ital Dermatol Venereol 2017 Aug 1;152(4):355-359. Epub 2016 Jun 1.

Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.

The management of melanoma is constantly evolving. New therapies and surgical advances have changed the landscape over the last years. Since being introduced by Dr Donald Morton, the role of sentinel lymph node has been debated. Read More

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http://dx.doi.org/10.23736/S0392-0488.16.05358-XDOI Listing
August 2017
9 Reads
0.491 Impact Factor

Status of the Regional Nodal Basin Remains Highly Prognostic in Melanoma Patients with In-Transit Disease.

J Am Coll Surg 2016 07 26;223(1):77-85.e1. Epub 2016 Mar 26.

Department of Medical Oncology, Mayo Clinic, Rochester, MN.

Background: The role of SLNB for in-transit (IT) melanoma is controversial. The objective of this study was to determine the rate and prognostic significance of occult nodal disease in patients undergoing surgical nodal staging for IT disease.

Study Design: We conducted a retrospective review of patients with IT melanoma from May 2005 through September 2014. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2016.03.025DOI Listing
July 2016
16 Reads