107 results match your criteria The Role of Antibiotics in Cutaneous Surgery

Surgical Site Infection After Dermatologic Procedures: Critical Reassessment of Risk Factors and Reappraisal of Rates and Causes.

Am J Clin Dermatol 2021 Apr 1. Epub 2021 Apr 1.

Department of Dermatology, State University of New York Downstate, Veterans Affairs Medical Center, 800 Poly Place, Brooklyn, NY, 11209, USA.

While rates are low, surgical site infections are the most common complication of dermatologic surgery. Surgical site infections have important consequences including impairment of wound healing, suboptimal cosmetic outcome, hospitalization, increased healthcare costs, and rarely, systemic infection. It is imperative to understand the risk factors and existing preventative measures to minimize the development of infection. Read More

View Article and Full-Text PDF

New Insights Into the Skin Microbial Communities and Skin Aging.

Front Microbiol 2020 26;11:565549. Epub 2020 Oct 26.

Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Although it is well-known that human skin aging is accompanied by an alteration in the skin microbiota, we know little about how the composition of these changes during the course of aging and the effects of age-related skin microbes on aging. Using 16S ribosomal DNA and internal transcribed spacer ribosomal DNA sequencing to profile the microbiomes of 160 skin samples from two anatomical sites, the cheek and the abdomen, on 80 individuals of varying ages, we developed age-related microbiota profiles for both intrinsic skin aging and photoaging to provide an improved understanding of the age-dependent variation in skin microbial composition. According to the landscape, the microbial composition in the Children group was significantly different from that in the other age groups. Read More

View Article and Full-Text PDF
October 2020

Update on the pathogenesis and management of ocular rosacea: an interdisciplinary review.

Eur J Ophthalmol 2021 Jan 25;31(1):22-33. Epub 2020 Jun 25.

Department of Ophthalmology, University of Illinois at Chicago, Chicago, IL, USA.

Purpose: Rosacea is one of the most common conditions affecting the ocular surface. The purpose of this review is to provide an update on the pathogenesis and treatment of rosacea based on the dermatology and ophthalmology literatures.

Methods: Literature searches were conducted for rosacea and ocular rosacea. Read More

View Article and Full-Text PDF
January 2021

Traditional and advanced therapeutic modalities for wounds in the paediatric population: an evidence-based review.

J Wound Care 2020 Jun;29(6):321-334

University of Miami Miller School of Medicine, Dr. Phillip Frost Dermatology and Cutaneous Surgery, 1321 NW 14th Street, Suite 506, Miami, FL 33125, US.

Objective: Children can have non-healing wounds due to a wide range of pathologies, including epidermolysis bullosa (EB), pilonidal disease and Stevens-Johnson syndrome, with some causes being iatrogenic, including extravasation injuries and medical device-related hospital-acquired pressure ulcers. Furthermore, paediatric wounds are vastly different from adult wounds and therefore require a different treatment approach. While there are numerous types of dressings, topical remedies, and matrices with high-tier evidence to support their use in adults, evidence is scarce in the neonatal and paediatric age groups. Read More

View Article and Full-Text PDF

Spontaneous community-acquired PVL-producing Staphylococcus aureus mediastinitis in an immunocompetent adult - a case report.

BMC Infect Dis 2020 May 19;20(1):354. Epub 2020 May 19.

Réanimation polyvalente, CHU Dupuytren, 2 avenue Martin Luther King, F-87000, Limoges, France.

Background: Mediastinitis caused by hematogenous spread of an infection is rare. We report the first known case of community-acquired mediastinitis from hematogenous origin in an immunocompetent adult. This rare invasive infection was due to Panton-Valentine Leucocidin-producing (PVL+) methicillin-susceptible Staphylococcus aureus (MSSA). Read More

View Article and Full-Text PDF

Regenerative potential of allogeneic adipose tissue-derived mesenchymal cells in canine cutaneous wounds.

Acta Vet Scand 2020 Mar 12;62(1):13. Epub 2020 Mar 12.

Experimental Hematology UCM-Research Group, Veterinary Faculty, Complutense University of Madrid, Avda. Puerta de Hierro s/n, 28040, Madrid, Spain.

Background: Mesenchymal stem cells (MSCs) have generated a great amount of interest over the past decade as a novel therapeutic treatment for a variety of diseases. Emerging studies have indicated that MSCs could enhance the repair of injured skin in canine cutaneous wounds.

Case Presentation: A healthy 2 years old Bodeguero Andaluz dog was presented with multiple skin bite wounds. Read More

View Article and Full-Text PDF

Evaluation of intestinal parasites in patients with chronic spontaneous urticaria in a territory hospital in Turkey.

J Infect Dev Ctries 2019 10 31;13(10):927-932. Epub 2019 Oct 31.

Department of Medical Microbiology, Ankara Education and Research Hospital, Health Sciences University, Ankara, Turkey.

Introduction: Chronic spontaneous urticaria (CSU) which develops without a known stimulation is defined as the occurrence of spontaneous wheals, angioedema or both for longer than six weeks. Infections, autoimmunity, food intolerance and internal parasitic infections are supposed to be underlying causes of CSU. The aim of this study was to evaluate the intestinal parasites in children and adult patients diagnosed as CSU, to determine the frequency of parasites in chronic urticaria, and to compare these patients with healthy demographic control groups. Read More

View Article and Full-Text PDF
October 2019

Postoperative Infections in Dermatologic Surgery: The Role of Wound Cultures.

Dermatol Surg 2020 10;46(10):1294-1299

Department of Dermatology, University of Missouri, Columbia, Missouri.

Background: Dermatologic surgery is associated with low postoperative infection rates, averaging from approximately 1% to 4.25%. Often, postoperative infections are treated empirically based on clinical diagnosis of infection, given it can take 48 to 72 hours for a wound culture to identify a pathogen. Read More

View Article and Full-Text PDF
October 2020

The treatment of Kyrle's disease: a systematic review.

J Eur Acad Dermatol Venereol 2020 Jul 5;34(7):1457-1463. Epub 2020 Feb 5.

The Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Kyrle's disease (KD) is a cutaneous disease that develops in individuals with underlying systemic disease, particularly chronic renal failure and diabetes mellitus (DM), and is associated with a high burden of disease linked to itch. The intensely pruritic, hyperkeratotic papulonodular rash seen in KD dramatically impairs patients' quality of life and increases their risk of mortality. Unfortunately, no guidelines or evidence-based regimens have been specifically developed for KD, making the treatment of this disease particularly challenging for physicians. Read More

View Article and Full-Text PDF

Electrochemotherapy for the treatment of primary basal cell carcinoma; A randomised control trial comparing electrochemotherapy and surgery with five year follow up.

Eur J Surg Oncol 2020 05 27;46(5):847-854. Epub 2019 Nov 27.

Cancer Research @ UCC, Western Gateway Building, University College Cork, Ireland.

Basal cell carcinoma (BCC) are the commonest cutaneous malignancy and incidence continues to increase. There is a need to expand the therapeutic toolbox to increase options for patients that are unsuitable for or unwilling to undergo the current therapies. Electrochemotherapy (ECT) is a technique where cells are temporarily permeabilized after exposure to a brief pulsed electrical field and combined with low dose chemotherapeutics to ablate malignancies. Read More

View Article and Full-Text PDF

Postoperative Antibiotic Use Among Patients Undergoing Functional Facial Plastic and Reconstructive Surgery.

JAMA Facial Plast Surg 2019 Dec;21(6):491-497

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford Hospital and Clinics, Stanford, California.

Importance: Best practices for antibiotic use after facial plastic and reconstructive procedures have been the subject of much debate, and there is a need for large-scale data to guide further development of evidence-based guidelines for antibiotic use in this setting.

Objective: To assess patterns of postoperative antibiotic prescriptions and infection rates after nasal and oculoplastic procedures.

Design, Setting, And Participants: A retrospective population-based cohort study was conducted using IBM MarketScan Commercial and Medicare Supplemental research databases of 294 039 patients who underwent facial plastic surgery procedures between January 1, 2007, and December 31, 2015. Read More

View Article and Full-Text PDF
December 2019

Biotin: overview of the treatment of diseases of cutaneous appendages and of hyperseborrhea.

G Ital Dermatol Venereol 2019 Oct;154(5):557-566

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, FL, USA.

One of the most common micronutrient deficiencies with cutaneous findings is the vitamin B, also known as biotin, deficiency. Biotin deficiency may be due to congenital lack of biotinidase, or acquired following some conditions that interfere with its absorption, such as inflammatory bowel disorders, a diet too rich in avidin, magnesium deficiency, smoking habit and treatment with broad-spectrum antibiotics, anticonvulsants and sulfonamides. This review highlights the role of biotin in the most common skin disorders such associated with biotin deficiency and an approach to their treatment. Read More

View Article and Full-Text PDF
October 2019

The Use of Full Thickness Skin Graft Phalloplasty During Adult Acquired Buried Penis Repair.

Urology 2019 Jul 18;129:223-227. Epub 2019 Apr 18.

Indiana University School of Medicine, Department of Urology, Indianapolis, IN. Electronic address:

Objective: To evaluate the feasibility and outcomes of full thickness penile skin grafting (FTSG) for phalloplasty during acquired buried penis repair.

Materials And Methods: A retrospective cohort study of patients undergoing complex genital reconstruction for buried penis between January 2013 and April 2018 was performed. Patients undergoing FTSG were identified. Read More

View Article and Full-Text PDF

Decolonization of in Healthcare: A Dermatology Perspective.

J Healthc Eng 2018 24;2018:2382050. Epub 2018 Dec 24.

Department of Dermatology, Tulane University, New Orleans, LA, USA.

The bacterium is responsible for significant morbidity, mortality, and financial burden in healthcare. It easily colonizes susceptible patients and can cause recurrent infections, especially in populations at risk. In addition to treating sequelae of infections, there is a growing body of literature aimed at decolonizing susceptible patients in order to prevent infection and also to prevent spread. Read More

View Article and Full-Text PDF
November 2019

Mycobacterium ulcerans disease management in Australian patients: the re-emergence of surgery as an important treatment modality.

ANZ J Surg 2019 06 21;89(6):653-658. Epub 2018 Sep 21.

Department of Plastic Surgery, Barwon Health, Geelong, Victoria, Australia.

With the demonstration of the effectiveness of antibiotic treatment, the management of Mycobacterium ulcerans disease has changed from a predominantly surgically to a predominantly medically treated disease. However, research among Australian patients has revealed that antibiotic treatment alone is associated with prolonged wound healing times, high rates of treatment toxicity, and the potential for significant tissue destruction associated with severe paradoxical reactions. We present the current state of M. Read More

View Article and Full-Text PDF

Trichogranuloma in a Hairdresser with Systemic Sclerosis.

Cureus 2018 May 25;10(5):e2690. Epub 2018 May 25.

Wolfson Diabetes and Endocrine Clinic, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge University Hospitals Nhs Foundation Trust, Cambridge, Uk.

Trichogranuloma is a rare occupational disease of hairdressers that develops when hair clippings penetrate the skin and cause a foreign-body reaction. We describe a case of a hairdresser with limited cutaneous systemic sclerosis who developed a chronic felon on her right third finger and received repeated courses of antibiotics without improvement. An occupational history and awareness of occupational diseases in hairdressers led to the correct diagnosis of trichogranuloma. Read More

View Article and Full-Text PDF

Gut microbes contribute to variation in solid organ transplant outcomes in mice.

Microbiome 2018 05 25;6(1):96. Epub 2018 May 25.

Department of Medicine, The University of Chicago, Chicago, USA.

Background: Solid organ transplant recipients show heterogeneity in the occurrence and timing of acute rejection episodes. Understanding the factors responsible for such variability in patient outcomes may lead to improved diagnostic and therapeutic approaches. Rejection kinetics of transplanted organs mainly depends on the extent of genetic disparities between donor and recipient, but a role for environmental factors is emerging. Read More

View Article and Full-Text PDF

Clindamycin-induced Maculopapular Exanthema with Preferential Involvement of Striae Distensae: A Koebner phenomenon?

Acta Dermatovenerol Croat 2018 Apr;26(1):61-63

Benigno Monteagudo-Sánchez, MD, Hospital Arquitecto Marcide, Avenida Residencia SN , 15405 Ferrol (A Coruńa), A Coruńa, Spain;

Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). Read More

View Article and Full-Text PDF

A Case Report and Literature Review of Scrub Typhus With Acute Abdomen and Septic Shock in a Child-The Role of Leukocytoclastic Vasculitis and Granulysin.

Am J Dermatopathol 2018 Oct;40(10):767-771

Department of Dermatology, Chang Gung Memorial Hospital, Linko, Taipei, Taiwan.

Scrub typhus is becoming a clinically important cause of acute undifferentiated febrile illness in Taiwan. The incubation period is between 6 and 21 days after exposure. It is transmitted by chiggers (larva of trombiculid mite) in long grasses and in dirt-floor homes, with infection characterized by a flu-like illness of fever, headache, and myalgia lasting approximately 1 week. Read More

View Article and Full-Text PDF
October 2018

Comparative Study of Drainage and Antibiotics versus Drainage Only in the Management of Primary Subcutaneous Abscesses.

Surg Infect (Larchmt) 2018 Apr 13;19(3):345-351. Epub 2018 Mar 13.

1 Department of Surgery, Mexican Institute of Social Security , Delicias, Mexico .

Background: Skin and soft tissue infections are common problems dealt with in emergency departments and medical offices. It is routine practice to prescribe antibiotic agents after incision and drainage of cutaneous abscesses. However, current evidence does not support prescribing oral antibiotic agents after surgical debridement. Read More

View Article and Full-Text PDF

Etiology of chronic skin lesions in subjects with peripheral arterial disease.

Clin Ter 2018 Mar-Apr;169(2):e51-e57

GF Ingrassia Department, Neurosciences Section, University of Catania, Italy.

Introduction: Skin lesions can be defined as lesions that result in loss of tissues and their joints, and often this cutaneous skin process is a primary or secondary consequence of the structural changes in the skin itself. Subjects with peripheral arteripathies that develop chronic skin lesions in the lower extremities of the Western world are constantly increasing. We conducted a study on the etiologic incidence of chronic skin lesions in peripheral arterial disease CSLpa subjects in the lower limbs compared to subjects with chronic skin lesions CSL (controls). Read More

View Article and Full-Text PDF

Cutaneous squamous cell carcinoma: Management of advanced and high-stage tumors.

J Am Acad Dermatol 2018 02;78(2):249-261

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

While the majority of cutaneous squamous cell carcinomas (cSCCs) can be treated surgically, the additional work-up and treatments indicated for high-risk cSCC remain undefined. In recent years, improvements in tumor staging systems have allowed for the more accurate stratification of tumors into high- and low-risk categories. This insight, along with the publication of cSCC guidelines, brings us closer to the development of a consensus approach. Read More

View Article and Full-Text PDF
February 2018

Cutaneous Hypersensitivity-Like Reactions Associated With Breast Implants: A Review.

Dermatol Surg 2018 Mar;44(3):323-329

Department of Dermatology, University of California Irvine, Irvine, California.

Background: Breast implantation is an increasingly common procedure for both cosmesis and reconstruction. Risk of cutaneous reactions to breast implants is low and typically described in postsurgical settings. Adverse skin hypersensitivity-like reactions to implants have also been reported but are not well described. Read More

View Article and Full-Text PDF

The role of zinc in the treatment of acne: A review of the literature.

Dermatol Ther 2018 Jan 28;31(1). Epub 2017 Nov 28.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.

Acne vulgaris is a chronic disease of the pilosebaceous units presenting as inflammatory or noninflammatory lesions in individuals of all ages. The current standard of treatment includes topical formulations in the forms of washes, gels, lotions, and creams such as antibiotics, antibacterial agents, retinoids, and comedolytics. Additionally, systemic treatments are available for more severe or resistant forms of acne. Read More

View Article and Full-Text PDF
January 2018

European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results from the treatment of mucosal cancers.

Eur J Cancer 2017 12;87:172-181

Department of Oncology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Experimental Drug and Gene Electrotransfer (C*EDGE), Department of Clinical Oncology and Palliative Care, Zealand University Hospital, Roskilde, Denmark. Electronic address:

Aim: Electrochemotherapy is an effective local treatment for cutaneous tumours and metastases. In this prospective trial, six European institutions investigated electrochemotherapy in recurrent, mucosal head and neck tumours.

Patient And Methods: Forty-three patients with recurrent mucosal head and neck tumours and no further curative or reasonably effective palliative treatment options were enrolled and treated with electrochemotherapy. Read More

View Article and Full-Text PDF
December 2017

Belimumab for the Treatment of Early Diffuse Systemic Sclerosis: Results of a Randomized, Double-Blind, Placebo-Controlled, Pilot Trial.

Arthritis Rheumatol 2018 02 29;70(2):308-316. Epub 2017 Dec 29.

Hospital for Special Surgery, New York, New York.

Objective: To assess the safety and efficacy of treatment with belimumab in patients with early diffuse cutaneous systemic sclerosis (dcSSc) treated with background mycophenolate mofetil (MMF).

Methods: In this 52-week, investigator-initiated, single-center, double-blind, placebo-controlled, pilot study, 20 patients with dcSSc recently started on MMF were randomized 1:1 to additionally receive belimumab at 10 mg/kg intravenously or placebo. We assessed safety, efficacy, and differential gene expression. Read More

View Article and Full-Text PDF
February 2018

Aseptic surgical preparation for upper eyelid blepharoplasty via full-face octenidine antiseptic without antibiotic medication shows effective prophylaxis against post-surgical wound infection.

Int Wound J 2018 Feb 23;15(1):84-89. Epub 2017 Oct 23.

Department of Plastic, Reconstructive and Aesthetic Surgery, Innsbruck Medical University, Innsbruck, Austria.

Blepharoplasty is the third most common plastic surgical procedure in the USA. Due to the emergence of multiresistant bacteria, optimising the antiseptic procedure is crucial. Choice of antiseptics plays an important role as they may cause skin irritation and colouring of disinfected areas. Read More

View Article and Full-Text PDF
February 2018

Post-reconstruction dermatitis of the breast.

J Plast Reconstr Aesthet Surg 2017 Oct 20;70(10):1369-1376. Epub 2017 May 20.

Department of Medicine, Dermatology Service, Memorial Sloan Kettering Cancer Center, 16 E 60th Street, New York, NY 10022, USA.

Background: Approximately one-third of women diagnosed with breast cancer undergo mastectomy with subsequent implant-based or autogenous tissue-based reconstruction. Potential complications include infection, capsular contracture, and leak or rupture of implants with necessity for explantation. Skin rashes are infrequently described complications of patients who undergo mastectomy with or without reconstruction. Read More

View Article and Full-Text PDF
October 2017

Ecthyma gangrenosum in a 3-month-old, previously healthy infant: A Case Report.

Medicine (Baltimore) 2017 Mar;96(10):e6244

Department of Dermatology Department of Urology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Department of Dermatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.

Rationale: Ecthyma gangrenosum (EG) is an aggressive cutaneous disease caused by local or systemic infection with Pseudomonas aeruginosa. EG is characterized by cutaneous manifestations ranging from nodule and papule, to necrotic ulceration with surrounding erythema, especially with black eschar or central crust. EG presents with characteristic skin lesions which is important to establish diagnosis of sepsis caused by P aeruginosa, a serious condition that can be treated efficiently if diagnosed early. Read More

View Article and Full-Text PDF

Cutaneous Tuberculosis.

Microbiol Spectr 2017 01;5(1)

Department of Medicine, Louisiana State University School of Medicine, New Orleans, LA 70112.

Cutaneous tuberculosis (TB) may present in various clinical manifestations. Skin involvement may occur as a result of exogenous inoculation, contiguous spread from a nearby focus of infection, or by hematogenous spread from a distant focus. Because the clinical presentation of cutaneous TB can vary widely, it is important to have a high index of suspicion in appropriate clinical settings. Read More

View Article and Full-Text PDF
January 2017