J Oral Maxillofac Surg 2014 Jul 14;72(7):1320-4. Epub 2014 Feb 14.
Department Head, Department of Trauma and General Surgery, Role III Multinational Medical Unit, Kandahar, Afghanistan, Plastic and Reconstructive Surgery Service, Walter Reed National Military Medical Center, Bethesda, MD, Adjunct Assistant Professor, University of Pittsburgh Medical Center, Pittsburgh, PA, Adjunct Assistant Professor, the Johns Hopkins University School of Medicine, Baltimore, MD, Assistant Professor, The Uniformed Services University of the Health Sciences, Bethesda, MD. Electronic address:
First described in 1924, necrotizing fasciitis (NF) is a rapidly progressing, severe suppurative infection of the superficial fascia, often associated with vascular thrombosis and necrosis of the overlying skin. Despite advances in medical therapy, the mortality remains high, with rates exceeding 25 to 50% in some studies. Early diagnosis and treatment is paramount in the management of this serious infection and should include wide surgical debridement and drainage of all necrotic tissues, coupled with aggressive parenteral antibiotics. Read More