11,954 results match your criteria The European journal of neuroscience[Journal]


N-Methyl-d-aspartate receptor open-channel blockers memantine and magnesium modulate nociceptive trigeminovascular neurotransmission in rats.

Eur J Neurosci 2019 Apr 22. Epub 2019 Apr 22.

Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.

Experimental and clinical studies suggest that the low-affinity N-methyl-d-aspartate (NMDA) receptor open-channel blockers Mg and memantine are effective in reducing trigeminal nociceptive activation. The aim of the present study was to investigate the apparent effectiveness of these channel blockers using a model of trigeminal activation in vivo. Rats were anesthetized before electrically stimulating the dura mater adjacent the middle meningeal artery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14423DOI Listing

Developmental changes in the excitatory short-term plasticity at input synapses in the rat inferior colliculus.

Eur J Neurosci 2019 Apr 19. Epub 2019 Apr 19.

Graduate School of Brain Science, Doshisha University, Kyoto, Japan.

The inferior colliculus (IC) is the primal center of convergence and integration in the auditory pathway. Although extensive functional changes are known to occur at the relay synapses in the auditory brainstem during development, the changes in the IC remain to be investigated. Here, we have measured excitatory postsynaptic currents (EPSCs) of the neurons in the central nucleus of the IC in response to stimulation of either the lateral lemniscus or the commissure of the inferior colliculus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14422DOI Listing

Tumor suppressor protein CYLD regulates morphogenesis of dendrites and spines.

Eur J Neurosci 2019 Apr 18. Epub 2019 Apr 18.

Department of Cellular Neurobiology, Graduate School of Medicine, University of Tokyo, Tokyo, 113-0033, Japan.

Cylindromatosis tumor suppressor protein (CYLD) was initially identified as a tumor suppressor deubiquitylating protein in familial cylindromatosis patients. Proteomic analyses using rodent brain samples revealed enrichment of CYLD in purified postsynaptic density fractions. Here we report that CYLD regulates dendritic growth and postsynaptic differentiation in mouse hippocampal neurons. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14421DOI Listing

Cross sex hormone treatment is linked with a reversal of cerebral patterns associated with gender dysphoria to the baseline of cisgender controls.

Eur J Neurosci 2019 Apr 16. Epub 2019 Apr 16.

Department of Women's and Children's Health, Karolinska Institutet and University Hospital, Stockholm, Sweden.

Transgender persons experience incongruence between their gender identity and birth-assigned sex. The resulting gender dysphoria (GD), is frequently treated with cross-sex hormones. However, very little is known about how this treatment affects the brain of individuals with GD,nor do we know the neurobiology of GD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14420DOI Listing

Beyond drug-induced alteration of glutamate homeostasis, astrocytes may contribute to dopamine-dependent intrastriatal functional shifts that underlie the development of drug addiction. A working hypothesis.

Eur J Neurosci 2019 Apr 9. Epub 2019 Apr 9.

Department of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.

The transition from recreational drug use to compulsive drug seeking habits, the hallmark of addiction, has been shown to depend on a shift in the locus of control over behaviour from the ventral to the dorsolateral striatum. This process has hitherto been considered to depend on the aberrant engagement of dopamine-dependent plasticity processes within neuronal networks. However, exposure to drugs of abuse also triggers cellular and molecular adaptations in astrocytes within the striatum which could potentially contribute to the intrastriatal transitions observed during the development of drug addiction. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.14416
Publisher Site
http://dx.doi.org/10.1111/ejn.14416DOI Listing
April 2019
2 Reads

Incentive and Dopamine Sensitization Produced by Intermittent But Not Long Access Cocaine Self-Administration.

Eur J Neurosci 2019 Apr 9. Epub 2019 Apr 9.

Department of Psychology (Biopsychology Program), University of Michigan, Ann Arbor, MI, USA.

The temporal pattern of drug use (pharmacokinetics) has a profound effect on the ability of self-administered cocaine to produce addiction-like behavior in rodents, and to change the brain. To further address this issue, we compared the effects of Long Access (LgA) cocaine self-administration, which is widely used to model the transition to addiction, with Intermittent Access (IntA), which is thought to better reflect the pattern of drug use in humans, on the ability of a single, self-administered injection of cocaine to increase dopamine (DA) overflow in the core of the nucleus accumbens (using in vivo microdialysis), and to produce addiction-like behavior. IntA experience was more effective than LgA in producing addiction-like behavior - a drug experience-dependent increase in motivation for cocaine assessed using behavioral economic procedures, and cue-induced reinstatement - despite much less total drug consumption. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14418DOI Listing

Diversity in the structure of action potential mediated neural connectivity within rat SCN.

Eur J Neurosci 2019 Apr 9. Epub 2019 Apr 9.

Department of Physics, Korea University, Seoul, 028841, Korea.

Action potential-mediated cell-to-cell communication is essential for the frequency-locking and phase-synchronization of the clock cells within the biological master clock, suprachiasmatic nucleus. Nevertheless, the morphology of its network connectivity is largely unexplored. Here, with an optimized optogenetic light-stimulation and scanning protocol, we report some key characteristics of the inhibitory receptive field (IRF), the area which brings inhibitory synaptic currents to a given target cell, and basic statistics of the inhibitory network connections of rat SCN clock cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14417DOI Listing

Editorial: Introduction to the Special Issue in Honour of Ray Guillery.

Eur J Neurosci 2019 Apr 9. Epub 2019 Apr 9.

Department of Neurobiology, University of Chicago, Chicago, IL, USA.

This issue of the European Journal of Neuroscience is dedicated to Rainer (Ray) Walter Guillery (28th August 1929-7th April 2017). Ray was an important, productive, and impactful neuroscientist and as such left an indelible mark on the field, both in terms of his direct contributions and also through his success at mentoring and nurturing young scholars who went on to successful careers of their own. He was also a great friend, colleague, and mentor to many of us. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14419DOI Listing

Maladaptive striatal plasticity and abnormal reward-learning in cervical dystonia.

Eur J Neurosci 2019 Apr 7. Epub 2019 Apr 7.

Division of Imaging Science and Technology, Medical School, University of Dundee, DD2 4BF, UK.

In monogenetic generalized forms of dystonia, in vitro neurophysiological recordings have demonstrated direct evidence for abnormal plasticity at the level of the cortico-striatal synapse. It is unclear whether similar abnormalities contribute to the pathophysiology of cervical dystonia, the most common type of focal dystonia. We investigated whether abnormal cortico-striatal synaptic plasticity contributes to abnormal reward-learning behavior in patients with focal dystonia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14414DOI Listing
April 2019
1 Read

Editorial: Special Issue in Honour of the First Editor of EJN, Ray Guillery.

Eur J Neurosci 2019 Apr 6. Epub 2019 Apr 6.

The Ernest J. Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA.

Ray was invited by the committee of the then European Neuroscience Association (ENA; soon to become Federation of European Neuroscience Societies), to establish the journal and act as the first editor. He took up the challenge with his usual scientific rigour, enthusiasm and disarming charm, and set the standards to which the many editors that have followed him have aspired (Guillery, 2015). This article is protected by copyright. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14415DOI Listing
April 2019
1 Read

Temporal Refinement of Sensory-Evoked Activity across Layers in Developing Mouse Barrel Cortex.

Eur J Neurosci 2019 Apr 3. Epub 2019 Apr 3.

Institute of Physiology, Duesbergweg 6, University Medical Center of the Johannes Gutenberg University, D-55128, Mainz, Germany.

Rhythmic whisking behavior in rodents fully develops during a critical period about two weeks after birth, in parallel with the maturation of other sensory modalities and the onset of exploratory locomotion. How whisker-related sensory processing develops during this period in the primary somatosensory cortex (S1) remains poorly understood. Here, we characterized neuronal activity evoked by single- or dual-whisker stimulation patterns in developing S1, before, during and after the occurrence of active whisking. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14413DOI Listing
April 2019
1 Read

Loss of striatal tyrosine-hydroxylase interneurons impairs instrumental goal-directed behavior.

Eur J Neurosci 2019 Apr 2. Epub 2019 Apr 2.

Department of Psychology; Rutgers, The State University of New Jersey, Newark, New Jersey, USA.

The striatum mediates a broad range of cognitive and motor functions. Within the striatum, recently discovered tyrosine hydroxylase expressing interneurons (THINs) provide a source of intrastriatal synaptic connectivity that is critical for regulating striatal activity, yet the role of THIN's in behavior remains unknown. Given the important role of the striatum in reward-based behaviors, we investigated whether loss of striatal THINs would impact instrumental behavior in mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14412DOI Listing
April 2019
1 Read

Effect of Acute Total Sleep Deprivation on Plasma Melatonin, Cortisol and Metabolite Rhythms in Females.

Eur J Neurosci 2019 Mar 30. Epub 2019 Mar 30.

Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK.

Disruption to sleep and circadian rhythms can impact on metabolism. The study aimed to investigate the effect of acute sleep deprivation on plasma melatonin, cortisol and metabolites, to increase understanding of the metabolic pathways involved in sleep/wake regulation processes. Twelve healthy young female subjects remained in controlled laboratory conditions for ~92 h with respect to posture, meals and environment light (18:00-23:00 h and 07:00-09:00 h <8 lux; 23:00-07:00 h 0 lux (sleep opportunity) or <8 lux (continuous wakefulness); 09:00-18:00 h ~ 90 lux). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14411DOI Listing

Central thalamic inactivation impairs the expression of action- and outcome-related responses of medial prefrontal cortex neurons in the rat.

Eur J Neurosci 2019 Mar 28. Epub 2019 Mar 28.

Department of Psychology, University of New Hampshire, Durham, New Hampshire.

The mediodorsal (MD) and adjacent intralaminar (IL) and midline nuclei provide the main thalamic input to the medial prefrontal cortex (mPFC) and are critical for associative learning and decision-making. MD neurons exhibit activity related to actions and outcomes that mirror responses of mPFC neurons in rats during dynamic delayed non-match to position (dDNMTP), a variation of DNMTP where start location is varied randomly within an open octagonal arena to avoid confounding behavioral events with spatial location. To test whether the thalamus affects the expression of these responses in mPFC, we inhibited the central thalamus unilaterally by microinjecting muscimol at doses and sites found to affect decision-making when applied bilaterally. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14350DOI Listing

Editorial Comment: Gender diversity in neuroscience: ongoing challenges for a field in flux.

Eur J Neurosci 2019 Mar 25. Epub 2019 Mar 25.

Department of Neuroscience, The Ernest J. Del Monte Institute for Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14410DOI Listing

The T-type calcium channel blocker Z944 reduces conditioned fear in Genetic Absence Epilepsy Rats from Strasbourg and the non-epileptic control strain.

Eur J Neurosci 2019 Mar 19. Epub 2019 Mar 19.

Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are a rodent model of childhood absence epilepsy (CAE) that display a gain-of-function mutation in the gene encoding the Cav3.2 T-type calcium channel. GAERS demonstrate heightened learning and delayed extinction of fear conditioning. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14406DOI Listing

Exercise during abstinence normalizes ultrastructural synaptic plasticity associated with nicotine-seeking following extended access self-administration.

Eur J Neurosci 2019 Mar 19. Epub 2019 Mar 19.

Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia.

Nicotine-craving progressively increases, or incubates, over abstinence following extended access self-administration. While not yet examined for nicotine, the incubation of cocaine-seeking is accompanied by changes in synaptic plasticity in the nucleus accumbens. Here, we determined whether such changes also accompany enhanced nicotine-seeking following extended access self-administration and abstinence, and whether exercise, a potential intervention for nicotine addiction, may exert its efficacy by normalizing these changes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14408DOI Listing
March 2019
2 Reads

Stress Resilience Evidenced by Grooming Behaviour and Dopamine Levels in Male Mice Selected for High And Low Immobility using the Tail Suspension Test.

Eur J Neurosci 2019 Mar 19. Epub 2019 Mar 19.

Department of Neuroscience and Behaviour, Institute of Psychology, University of São Paulo.

Grooming behaviour has different functions on many species during development and can be observed and affected during periods of stress. By selecting male mice with high (HI) and low (LI) immobility traits in the tail suspension test, a screening for antidepressant drugs, we investigate how these phenotypes associated with grooming behaviour may be influenced by the effects of repeated restraint stress. For this we used the sucrose preference test and the splash test in a novel and a familiar cage performed before and after exposure to 2 days of restraint stress. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14409DOI Listing

Blinding is compromised for transcranial direct current stimulation at 1 mA for 20 min in young healthy adults.

Eur J Neurosci 2019 Mar 19. Epub 2019 Mar 19.

Department of Psychology, University of Tromsø, Tromsø, Norway.

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation method that is frequently used to study cortical excitability changes and their impact on cognitive functions in humans. While most stimulators are capable of operating in double-blind mode, the amount of discomfort experienced during tDCS may break blinding. Therefore, specifically designed sham stimulation protocols are being used. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14403DOI Listing

Inducible and reversible silencing of the Pvalb gene in mice: an in vitro and in vivo study.

Eur J Neurosci 2019 Mar 18. Epub 2019 Mar 18.

Department of Neuroscience & Movements Science, Section of Medicine, University of Fribourg, Route Albert-Gockel 1, CH-1700, Fribourg, Switzerland.

Inducible and reversible regulation of gene expression is a powerful approach for unraveling gene functions. Here we describe the generation of a system to efficiently downregulate in a reversible and inducible manner the Pvalb gene coding for the calcium-binding protein parvalbumin (PV) in mice. We made use of an IPTG-inducible short-hairpin RNA to activate Pvalb transcript knockdown and subsequently downregulate PV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14404DOI Listing
March 2019
1 Read

Isoform-selective as opposed to complete depletion of fibroblast growth factor 2 (FGF-2) has no major impact on survival and gene expression in SOD1 amyotrophic lateral sclerosis mice.

Eur J Neurosci 2019 Mar 18. Epub 2019 Mar 18.

Department of Neurology, Hannover Medical School, Hannover, Germany.

We have previously shown that total knockout of fibroblast growth factor-2 (FGF-2) results in prolonged survival and improved motor performance in superoxide dismutase 1 (SOD1 ) mutant mice, the most widely used animal model of the fatal adult onset motor neuron disease amyotrophic lateral sclerosis (ALS). Moreover, we found differential expression of growth factors in SOD1 mice, with distinct regulation patterns of FGF-2 in spinal cord and muscle tissue. Within the present study we aimed to characterize FGF-2-isoform specific effects on survival, motor performance as well as gene expression patterns predominantly in muscle tissue by generating double mutant SOD1 FGF-2 high molecular weight- and SOD1 FGF-2 low molecular weight-knockout mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14405DOI Listing
March 2019
2 Reads

Modulatory effects of cannabinoids on brain neurotransmission.

Eur J Neurosci 2019 Mar 18. Epub 2019 Mar 18.

Department of Behavioral Science, Ariel University, Science Park, 40700, Ariel, Israel.

Recreational and chronic cannabis use has been associated with a range of acute and chronic effects including; anti-nociceptive actions, anxiety, depression, psychotic symptoms and neurocognitive impairments. The mechanisms underlying cannabinoid-based drugs effects are not fully known but given the neuro-modulatory functions of the endocannabinoid system, it seems likely that agonistic activity at the cannabinoid type-1 receptors (CB ) might modulate the functions of other neurotransmitter systems. The present review has summarized the currently available pre-clinical and clinical data on the interactions of CB and cannabinoid type-2 receptors (CB ) with the central neurotransmitters; dopamine, serotonin, noradrenaline, GABA, glutamate and opioids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14407DOI Listing

Methylphenidate dose-response behavioral and neurophysiological study of the ventral tegmental area and nucleus accumbens in adolescent rats.

Eur J Neurosci 2019 Mar 13. Epub 2019 Mar 13.

University of Texas McGovern Medical School, Houston, Texas.

The psychostimulant methylphenidate (MPD) is the most common medication used in treating ADHD in children. Studies have shown an increasing prevalence among adolescents without ADHD to take MPD as a cognitive booster and recreational drug, even though it is a Schedule II drug and has a high potential for abuse. The objective of this study is to explore if there is an association between the animals' behavioral and neurophysiological responses to acute and/or chronic methylphenidate exposure within the ventral tegmental area and the nucleus accumbens, and to compare how these two brain structures fire in response to methylphenidate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14402DOI Listing

Visual crowding involves delayed frontoparietal response and enhanced top-down modulation.

Authors:
Qiming Han Huan Luo

Eur J Neurosci 2019 Mar 12. Epub 2019 Mar 12.

School of Psychological and Cognitive Sciences, Peking University, Beijing, China.

Crowding, the disrupted recognition of a peripheral target in the presence of nearby flankers, sets a fundamental limit on peripheral vision perception. Debates persist on whether the limit occurs at early visual cortices or is induced by top-down modulation, leaving the neural mechanism for visual crowding largely unclear. To resolve the debate, it is crucial to extract the neural signals elicited by the target from that by the target-flanker clutter, with high temporal resolution. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/ejn.14401
Publisher Site
http://dx.doi.org/10.1111/ejn.14401DOI Listing
March 2019
11 Reads

Opposite responses to aversive stimuli in lateral habenula neurons.

Eur J Neurosci 2019 Mar 12. Epub 2019 Mar 12.

Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.

Appropriate behavioural strategies to cope with unexpected salient stimuli require synergistic neuronal responses in diverse brain regions. Among them, the epithalamic lateral habenula (LHb) plays a pivotal role in processing salient stimuli of aversive valence. Integrated in the complex motivational circuit, LHb neurons are indeed excited by aversive stimuli, including footshock (Fs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14400DOI Listing

Dynamic Cell Type-specific Expression of Nrf2 After Traumatic Brain Injury in Mice.

Eur J Neurosci 2019 Mar 4. Epub 2019 Mar 4.

Department of Forensic Pathology, China Medical University School of Forensic Medicine, Shenyang, 110122, China.

Nrf2 plays a pivotal role in antioxidant response and anti-inflammation after traumatic brain injury (TBI), and its deletion aggravates TBI-induced brain damage. Previous studies have demonstrated that Nrf2 is activated post TBI, but dynamic changes in expression and cell type-specific characteristics remain unclear. In this study, the Feeney weight-drop contusion model was conducted to mimic TBI, and the ipsilateral cerebral cortex was collected at 1, 3, 7 and 14 days post TBI (dpi). Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/ejn.14399
Publisher Site
http://dx.doi.org/10.1111/ejn.14399DOI Listing
March 2019
4 Reads

Beta band oscillatory deficits during working memory encoding in adolescents with attention-deficit hyperactive disorder.

Eur J Neurosci 2019 Mar 2. Epub 2019 Mar 2.

Centre for Molecular Medicine and Biobanking, University of Malta, Msida, Malta.

Attention-deficit hyperactivity disorder (ADHD) is a neurobehavioural disorder, characterized by symptoms of inattention and/or hyperactivity/impulsivity, in addition to various cognitive deficits, including working memory impairments. This pathology arises from a complex constellation of genetic, structural and neurotransmission abnormalities, which give rise to the aberrant electrophysiological patterns evident in patients with ADHD. Among such, findings have consistently provided support in favour of weaker power across the beta frequency range. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14398DOI Listing
March 2019
3 Reads

Gender bias in (neuro)science: Facts, consequences, and solutions.

Eur J Neurosci 2019 Feb 27. Epub 2019 Feb 27.

Women in Neuroscience Repository (WiNRepo) Board, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14397DOI Listing
February 2019

The speed of neuronal adaptation: A perspective through the visual cortex.

Eur J Neurosci 2019 Feb 25. Epub 2019 Feb 25.

Neurophysiology of Visual System, Département de Sciences Biologiques, Université de Montréal, Montréal, Quebec.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14393DOI Listing
February 2019

Orexin A depolarises rat intergeniculate leaflet neurons through non-selective cation channels.

Eur J Neurosci 2019 Feb 25. Epub 2019 Feb 25.

Department of Neurophysiology and Chronobiology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University in Krakow, Krakow, Poland.

Orexins/hypocretins are hypothalamic neuropeptides that have a variety of functions, including maintenance of arousal, control over the sleep/wake cycle, reward and feeding. Accumulating evidence links orexins to the time-keeping system with a documented action in the master clock-the suprachiasmatic nucleus. The intergeniculate leaflet (IGL) is a thalamic structure with the well-known function of collecting photic and non-photic cues to adjust the rhythm of the suprachiasmatic nucleus to changing environmental conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14394DOI Listing
February 2019

Expectancy modulates pupil size both during endogenous orienting and during re-orienting of spatial attention: A study with isoluminant stimuli.

Eur J Neurosci 2019 Feb 25. Epub 2019 Feb 25.

Laboratorio di Neuropsicologia dell'attenzione, Fondazione Santa Lucia IRCCS, Roma, Italy.

We have recently demonstrated that when endogenous orienting of spatial attention is guided by central directional cues that reliably predict the position of lateral targets. Pupil Dilation (PDil) is higher as compared with directional cues that do not predict target position. These findings were interpreted as reflecting different levels of Locus Coeruleus-Noradrenergic activity during endogenous orienting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14391DOI Listing
February 2019

Development and topographical organization of projections from the hippocampus and parahippocampus to the retrosplenial cortex.

Eur J Neurosci 2019 Feb 25. Epub 2019 Feb 25.

Kavli Institute for Systems Neuroscience, Centre for Neural Computation, Egil and Pauline Braathen and Fred Kavli Center for Cortical Microcircuits, NTNU Norwegian University for Science and Technology, Trondheim, Norway.

The rat hippocampal formation (HF), parahippocampal region (PHR), and retrosplenial cortex (RSC) play critical roles in spatial processing. These regions are interconnected, and functionally dependent. The neuronal networks mediating this reciprocal dependency are largely unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14395DOI Listing
February 2019
1 Read

Detecting neuroinflammation in the brain following chronic alcohol exposure in rats: A comparison between in vivo and in vitro TSPO radioligand binding.

Eur J Neurosci 2019 Feb 25. Epub 2019 Feb 25.

National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland.

Excessive alcohol consumption is associated with neuroinflammation, which likely contributes to alcohol-related pathology. However, positron emission tomography (PET) studies using radioligands for the 18-kDa translocator protein (TSPO), which is considered a biomarker of neuroinflammation, reported decreased binding in alcohol use disorder (AUD) participants compared to controls. In contrast, autoradiographic findings in alcohol exposed rats reported increases in TSPO radioligand binding. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/ejn.14392
Publisher Site
http://dx.doi.org/10.1111/ejn.14392DOI Listing
February 2019
15 Reads

Conversations with ray Guillery on albinism: linking Siamese cat visual pathway connectivity to mouse retinal development.

Authors:
Carol Mason

Eur J Neurosci 2019 Feb 23. Epub 2019 Feb 23.

Departments of Pathology and Cell Biology, Neuroscience, and Ophthalmology, Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, Jerome L. Greene Science Center, 3227 Broadway, Room L3-043, Quad 3C, New York, N.Y, 10027, USA.

In albinism of all species, perturbed melanin biosynthesis in the eye leads to foveal hypoplasia, retinal ganglion cell misrouting, and, consequently, altered binocular vision. Here, written before he died, Ray Guillery chronicles his discovery of the aberrant circuitry from eye to brain in the Siamese cat. Ray's characterization of visual pathway anomalies in this temperature sensitive mutation of tyrosinase and thus melanin synthesis in domestic cats opened the exploration of albinism and simultaneously, a genetic approach to the organization of neural circuitry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14396DOI Listing
February 2019
1 Read

Vascular and non-vascular contributors to memory reduction during traumatic brain injury.

Eur J Neurosci 2019 Feb 21. Epub 2019 Feb 21.

Department of Physiology, School of Medicine, University of Louisville, Louisville, Kentucky.

Traumatic brain injury (TBI) is an increasing health problem. It is a complex, progressive disease that consists of many factors affecting memory. Studies have shown that increased blood-brain barrier (BBB) permeability initiates pathological changes in neuro-vascular network but the role of cerebrovascular dysfunction and its mediated mechanisms associated with memory reduction during TBI are still not well understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14390DOI Listing
February 2019
1 Read

From clock to functional pacemaker.

Eur J Neurosci 2019 Feb 21. Epub 2019 Feb 21.

Group Neurophysiology, Dept Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.

In mammals, the central pacemaker that coordinates 24-hour rhythms is located in the suprachiasmatic nucleus (SCN). Individual neurons of the SCN have a molecular basis for rhythm generation and hence, they function as cell autonomous oscillators. Communication and synchronization among these neurons are crucial for obtaining a coherent rhythm at the population level, that can serve as a pace making signal for brain and body. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14388DOI Listing
February 2019

Cerebrospinal fluids from Alzheimer's disease patients exhibit neurotoxic effects on neuronal cell cultures.

Eur J Neurosci 2019 Feb 21. Epub 2019 Feb 21.

Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania.

A growing number of studies suggest amyloid-β and tau present in cerebrospinal fluid (CSF) and blood as putative biomarkers for Alzheimer's disease (AD). However, there is a question whether these compounds present in patients' bodily fluids can directly cause neurotoxic effects. We investigated effects of AD and other dementia (OD) patients' blood serum and CSF on viability of cells in primary cerebellar granule cell cultures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14389DOI Listing
February 2019
4 Reads

Lipid markers and related transcripts during excitotoxic neurodegeneration in kainate-treated mice.

Eur J Neurosci 2019 Feb 14. Epub 2019 Feb 14.

Inserm U1127, CNRS UMR7225, Sorbonne Université, UPMC Université Paris 6 UMR S1127, Institut du Cerveau et de la Moelle Epinière, CHU Pitié-Salpêtrière, Paris, France.

Lipid homeostasis is dysregulated in some neurodegenerative diseases and after brain injuries due to excess glutamate or lack of oxygen. However the kinetics and cell specificity of dysregulation in different groups of lipids during excitotoxic neuronal death are not clear. Here we examined the changes during excitotoxic neuronal death induced by injecting kainic acid (KA) into the CA1 region of mouse hippocampus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14375DOI Listing
February 2019
3 Reads

Pharmaco-electroencephalographic reponses in the rat differ between active and inactive locomotor states.

Eur J Neurosci 2019 Feb 14. Epub 2019 Feb 14.

H. Lundbeck A/S, Valby, Denmark.

Quantitative electroencephalography from freely moving rats is commonly used as a translational tool for predicting drug-effects in humans. We hypothesized that drug-effects may be expressed differently depending on whether the rat is in active locomotion or sitting still during recording sessions, and proposed automatic state-detection as a viable tool for estimating drug-effects free of hypo-/hyperlocomotion-induced effects. We aimed at developing a fully automatic and validated method for detecting two behavioural states: active and inactive, in one-second intervals and to use the method for evaluating ketamine, DOI, d-cycloserine, d-amphetamine, and diazepam effects specifically within each state. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14373DOI Listing
February 2019
1 Read

Effect of oxidative stress in rostral ventrolateral medulla on sympathetic hyperactivity after traumatic brain injury.

Eur J Neurosci 2019 Feb 14. Epub 2019 Feb 14.

Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Sympathetic hyperactivity occurs in a subgroup of patients after traumatic brain injury (TBI). The rostral ventrolateral medulla (RVLM) is a key region for the activity of sympathetic nervous system. Oxidative stress in the RVLM is proved to be responsible for the increased level of sympathetic activity in animal models of hypertension and heart failure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14374DOI Listing
February 2019

African neuroscience on the global stage: Nigeria as a model.

Eur J Neurosci 2019 Feb 13. Epub 2019 Feb 13.

School of Life Sciences, University of Sussex, Brighton, UK.

Of the 572 neuroscience-related studies published in Nigerian from 1996 to 2017, <5% used state-of-the-art techniques, none used transgenic models, and only one study was published in a top-tier journal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14372DOI Listing
February 2019
3.181 Impact Factor

Does fMRI repetition suppression reveal mirror neuron activity in the human brain? Insights from univariate and multivariate analysis.

Eur J Neurosci 2019 Feb 13. Epub 2019 Feb 13.

Cognitive Neuroscience Unit, School of Psychology, Deakin University, Geelong, Victoria, Australia.

Mirror neurons (MN) have been proposed as the neural substrate for a wide range of clinical, social and cognitive phenomena. Over the last decade, a commonly used tool for investigating MN activity in the human brain has been functional magnetic resonance (fMRI) repetition suppression (RS) paradigms. However, the available evidence is mixed, largely owing to inconsistent application of the methodological criteria necessary to infer MN properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14370DOI Listing
February 2019

The nociceptive withdrawal reflex of the trunk is organized with unique muscle receptive fields and motor strategies.

Eur J Neurosci 2019 Feb 11. Epub 2019 Feb 11.

NHMRC Centre of Clinical Research Excellence in Spinal Pain, Injury & Health, School of Health & Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia.

Noxious stimuli induce a nociceptive withdrawal reflex (NWR) to protect the tissue from injury. Although the NWR was once considered as a stereotyped response, previous studies report distinct responses depending on the stimulation site and context for limbs. We aimed to determine whether noxious stimuli over the trunk produced adaptable complex NWR. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/ejn.14369
Publisher Site
http://dx.doi.org/10.1111/ejn.14369DOI Listing
February 2019
6 Reads

Hippocampal activation of 5-HT receptors and BDNF production by vagus nerve stimulation in rats under chronic restraint stress.

Eur J Neurosci 2019 Feb 8. Epub 2019 Feb 8.

Department of Oriental Medicine, Daejeon University, Daejeon, Korea.

A growing body of evidence shows that the electrical stimulation of the vagus nerve can improve mental illness including depression. Here, we investigated whether the vagus nerve stimulation (VNS) is involved in regulating the responsiveness of hippocampal neurons in rats under chronic restraint stress (CRS). c-Fos protein signals were detected 2 hr after VNS in 5-HT receptor-positive neurons in the dorsal raphe nucleus (DRN) as well as in the nucleus tractus solitarius (NTS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14368DOI Listing
February 2019
2 Reads

Papers arising from the 12th International Basal Ganglia Society Meeting. March 26th-30th 2017, Mérida, Yucatán, México.

Eur J Neurosci 2019 Mar;49(5):591-592

Department of Pharmacology, MRC Brain Network Dynamics Unit, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14367DOI Listing

Ocular drift reflects volitional action preparation.

Eur J Neurosci 2019 Feb 5. Epub 2019 Feb 5.

New Zealand Brain Research Institute, Christchurch, New Zealand.

Human cognitive behavior is predictive rather than reflexive because of volitional action preparation. Recent studies have shown that the covert process of volitional action preparation can be decoded from overt fixational eye movements of fixational/microsaccades and pupil dilation. Ocular drift, the slowest fixational eye movements, is also under the active neural control, but its relationship with cognitive behavior is unknown. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.14365
Publisher Site
http://dx.doi.org/10.1111/ejn.14365DOI Listing
February 2019
8 Reads

Association of cardiorespiratory fitness on interhemispheric hippocampal and parahippocampal functional connectivity.

Eur J Neurosci 2019 Feb 5. Epub 2019 Feb 5.

Exercise and Memory Laboratory, Department of Health, Exercise Science and Recreation Management, The University of Mississippi, Oxford, Mississippi.

Interhemispheric functional connectivity is associated with cognitive functioning. Although previous work has evaluated the association of cardiorespiratory fitness on cognitive function, there has been a limited investigation of the association of cardiorespiratory fitness on the functional connectivity of memory-related brain structures. As such, the objective of this study was to examine the association between cardiorespiratory fitness and parahippocampal and hippocampal interhemispheric functional connectivity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14366DOI Listing
February 2019

Dissociating the neural substrates for inhibition and shifting in domain-general cognitive control.

Eur J Neurosci 2019 Feb 1. Epub 2019 Feb 1.

State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.

Inhibition and shifting are two key components of domain-general cognitive control. Numerous studies have investigated the neural substrates of both components, but it is still unclear whether the relevant brain regions are specifically involved in one specific component or commonly engaged in both components. Here, we addressed this question by using functional magnetic resonance imaging and a modified saccade paradigm that was effective to disentangle inhibition and shifting in one experiment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14364DOI Listing
February 2019

Electrophysiological markers of poor versus superior math abilities in healthy individuals.

Eur J Neurosci 2019 Jan 31. Epub 2019 Jan 31.

Department of Psychology, University of Milano-Bicocca, Milan, Italy.

Interindividual differences in the numerical ability of healthy adults have been previously demonstrated, mainly with tasks involving mental number line or size representation. However, electrophysiological correlates of superior versus poor arithmetic ability (in the healthy population) have been scarcely investigated. We correlated electric potentials with math performance in 13 skilled and 13 poor calculators selected from a sample of 41 graduate students on the basis of their poor or superior math abilities assessed through a timed test. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.14363DOI Listing
January 2019
2 Reads