293 results match your criteria The EPMA Journal [Journal]


Radiomics improves efficiency for differentiating subclinical pheochromocytoma from lipid-poor adenoma: a predictive, preventive and personalized medical approach in adrenal incidentalomas.

EPMA J 2018 Dec 21;9(4):421-429. Epub 2018 Sep 21.

7Department of Radiology, Keck Medical Center of USC, Los Angeles, CA USA.

Objectives: This study aims to define a radiomic signature for pre-operative differentiation between subclinical pheochromocytoma (sPHEO) and lipid-poor adrenal adenoma (LPA) in adrenal incidentaloma. The goal was to apply a predictive, preventive, and personalized medical approach to the management of adrenal tumors.

Patients And Methods: This retrospective study consisted of 265 consecutive patients (training cohort, 212 (LPA, 145; sPHEO, 67); validation cohort, 53 (LPA, 36; sPHEO, 17)). Read More

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http://dx.doi.org/10.1007/s13167-018-0149-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261906PMC
December 2018
1 Read

Plant natural modulators in breast cancer prevention: status quo and future perspectives reinforced by predictive, preventive, and personalized medical approach.

EPMA J 2018 Dec 12;9(4):403-419. Epub 2018 Nov 12.

1Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.

In contrast to the genetic component in mammary carcinogenesis, epigenetic alterations are particularly important for the development of sporadic breast cancer (BC) comprising over 90% of all BC cases worldwide. Most of the DNA methylation processes are physiological and essential for human cellular and tissue homeostasis, playing an important role in a number of key mechanisms. However, if dysregulated, DNA methylation contributes to pathological processes such as cancer development and progression. Read More

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http://dx.doi.org/10.1007/s13167-018-0154-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261910PMC
December 2018
2 Reads

Predictive and individualized management of stroke-success story in Czech Republic.

EPMA J 2018 Dec 25;9(4):393-401. Epub 2018 Oct 25.

1Department of Neurology, Faculty of Medicine in Pilsen, Charles University, Husova 3, 301 66 Plzen, Czech Republic.

The model of centralized stroke care in the Czech Republic was created in 2010-2012 by Ministry of Health (MH) in cooperation with professional organization-Cerebrovascular Section of the Czech Neurological Society (CSCNS). It defines priorities of stroke care, stroke centers, triage of suspected stroke patients, stroke care quality indicators, their monitoring, and reporting. Thirteen complex cerebrovascular centers (CCC) provide sophisticated stroke care, including intravenous thrombolysis (IVT), mechanical thrombectomy (MTE), as well as other endovascular (stenting, coiling) and neurosurgical procedures. Read More

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http://link.springer.com/10.1007/s13167-018-0150-x
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http://dx.doi.org/10.1007/s13167-018-0150-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261911PMC
December 2018
9 Reads

In glaucoma patients, low blood pressure is accompanied by vascular dysregulation.

EPMA J 2018 Dec 12;9(4):387-391. Epub 2018 Nov 12.

Department of Ophthalmology, University of Basel, Mittlere Strasse 91, CH-4031 Basel, Switzerland.

Background: There are many risk factors contributing to glaucomatous optic neuropathy. Beside increased intraocular pressure, vascular factors play a prominent role, particularly low blood pressure (BP), and vascular dysregulation. Both of them are essential components of the Flammer syndrome. Read More

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http://dx.doi.org/10.1007/s13167-018-0155-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261908PMC
December 2018
2 Reads

Characteristics of dental patients determining their compliance level in dentistry: relevance for predictive, preventive, and personalized medicine.

EPMA J 2018 Dec 13;9(4):379-385. Epub 2018 Nov 13.

5Department of General and Clinical Psychology, Pavlov First Saint Petersburg State Medical University, 6/8 Lva Tolstogo Street, St. Petersburg, Russia.

This article centers on the relationship between psychological specifics of dental patients and their adherence to treatment. It describes clinical and personality specifics of periodontal patients and presents personality characteristics of patients with positive and negative dynamics of the therapy, as well as patients without periodontal diseases. The study findings highlight the importance of building confidential relationships with the patient and the need for a client-oriented approach to developing treatment plans and strategies for different types of dental patients. Read More

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http://dx.doi.org/10.1007/s13167-018-0152-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261882PMC
December 2018
1 Read

Suboptimal health status and psychological symptoms among Chinese college students: a perspective of predictive, preventive and personalised health.

EPMA J 2018 Dec 28;9(4):367-377. Epub 2018 Aug 28.

1School of Public Health, Taishan Medical University, 619 Changcheng Road, Taian, 271016 People's Republic of China.

Background: Suboptimal health status (SHS) is an intermediate health status between health and illness, a syndrome characterised by the perception of health complaints, general weakness and low energy. This study aimed to investigate the prevalence of SHS and the correlation between SHS and psychological symptoms among Chinese college students and to identify the SHS-related risk factors from the perspective of predictive, preventive and personalised medicine (PPPM).

Methods: A cross-sectional study was conducted among 4119 college students who were enrolled from Medical University and Vocational and Technical College in the eastern and western areas of China. Read More

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http://dx.doi.org/10.1007/s13167-018-0148-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261912PMC
December 2018
2 Reads

The role of the personality traits and work characteristics in the prediction of the burnout syndrome among nurses-a new approach within predictive, preventive, and personalized medicine concept.

EPMA J 2018 Dec 25;9(4):355-365. Epub 2018 Oct 25.

1Transilvania University of Brasov, 29, Eroilor Street, 500036 Brasov, Romania.

Background: The burnout syndrome is characterized by emotional exhaustion, depersonalization, and lack of personal accomplishment. It was identified in some professional categories, the most often being affected those in public health services.

Objectives: This study mainly aims to identify and analyze the value of the personality traits and work characteristics as predictive factors for the occurrence of the burnout syndrome in nurses, under the new approach of predictive, preventive, and personalized medicine. Read More

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http://dx.doi.org/10.1007/s13167-018-0151-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261904PMC
December 2018
1 Read

Biobanks in Horizon 2020: sustainability and attractive perspectives.

EPMA J 2018 Dec 23;9(4):345-353. Epub 2018 Nov 23.

Department of Immunochemistry, University Hospital Pilsen, Edvarda Benese 1128/13, 305 99 Pilsen, CZ Czech Republic.

Biobanks have during last two decades gained an important role in the whole process of biomedical research and health care not only in Europe but also worldwide. Biobanks are one of the pillars in personalised medicine tackling all its aspects such as prevention, diagnosis, treatment and monitoring closely the specific characteristics of an individual patient. The current and future power of biobanks is the amount of samples of high-quality and related information available for current and future research of diseases, for optimising patients´ prevention, diagnosis, treatment and monitoring. Read More

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http://link.springer.com/10.1007/s13167-018-0153-7
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http://dx.doi.org/10.1007/s13167-018-0153-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261881PMC
December 2018
8 Reads

Titanium implants and silent inflammation in jawbone-a critical interplay of dissolved titanium particles and cytokines TNF-α and RANTES/CCL5 on overall health?

EPMA J 2018 Sep 8;9(3):331-343. Epub 2018 Jun 8.

Institute for Medical Diagnostics in MVZ GbR, Nicolaistr. 22, 12247 Berlin, Germany.

Background And Introduction: It is a well-known fact that titanium particles deriving from dental titanium implants (DTI) dissolve into the surrounding bone. Although titanium (TI) is regarded as a compatible implant material, increasing concern is coming up that the dissolved titanium particles induce inflammatory reactions around the implant. Specifically, the inflammatory cytokine tumor necrosis factor-alpha (TNF-α) is expressed in the adjacent bone. Read More

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http://dx.doi.org/10.1007/s13167-018-0138-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107454PMC
September 2018
2 Reads

Efficiency of dental caries prevention with the use of polymer-based toothpastes modified by the electromagnetic field.

EPMA J 2018 Sep 14;9(3):319-329. Epub 2018 Aug 14.

3Dentistry Faculty, The Department of Periodontology, Cukurova University, Adana, Turkey.

The most important problems of modern dentistry cover not only the early diagnosis but also prevention of dental caries, including the one based on the use of various hygienic products and therapeutic agents. Normally, the processes of re- and demineralization in the oral cavity are in a state of dynamic. However, in the presence of cariogenic factors, the balance is shifted towards demineralization. Read More

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http://dx.doi.org/10.1007/s13167-018-0140-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107453PMC
September 2018
3 Reads

"Dry mouth" and "Flammer" syndromes-neglected risks in adolescents and new concepts by predictive, preventive and personalised approach.

EPMA J 2018 Sep 2;9(3):307-317. Epub 2018 Aug 2.

4Radiological Clinic, Rheinische Friedrich-Wilhelms-University of Bonn, Sigmund-Freud-Str 25, 53105 Bonn, Germany.

Background: "Dry mouth" syndrome (chronic hyposalivation) can be caused by a number of pathophysiological conditions such as acute and chronic stress exposure, abnormal body weight (both too high and too low ones), eating disorders (such as ), metabolic syndrome(s), Sjögren's and Sicca syndromes, drugs and head/neck radiotherapy application. In turn, the chronic hyposalivation as a suboptimal health condition significantly reduces quality of life, may indicate a systemic dehydration, provokes and contributes to a number of pathologies such as a strongly compromised protection of the oral cavity, chronic infections and inflammatory processes, periodontitis, voice and digestive disorders. Consequently, "dry mouth" syndrome might be extremely useful as an indicator for an in-depth diagnostics of both-co-existing and snowballing health-threating conditions. Read More

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http://link.springer.com/10.1007/s13167-018-0145-7
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http://dx.doi.org/10.1007/s13167-018-0145-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107455PMC
September 2018
19 Reads

Latent class analysis to evaluate performance of plasma cortisol, plasma catecholamines, and SHSQ-25 for early recognition of suboptimal health status.

EPMA J 2018 Sep 1;9(3):299-305. Epub 2018 Aug 1.

1Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, Beijing, China.

Background: Chronic stress is associated with suboptimal health status (SHS) which is a new public health challenge in China and worldwide. Plasma stress hormones may act as potential objective biomarkers for SHS measure. This study was aimed to evaluate the diagnostic performance of plasma cortisol, catecholamine adrenaline/noradrenaline, and SHS questionnaires (SHSQ) for SHS using latent class analysis (LCA) in the absence of a gold standard. Read More

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http://dx.doi.org/10.1007/s13167-018-0144-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107457PMC
September 2018
17 Reads

Individualized metabolic profiling stratifies pancreatic and biliary tract cancer: a useful tool for innovative screening programs and predictive strategies in healthcare.

EPMA J 2018 Sep 17;9(3):287-297. Epub 2018 Aug 17.

1Biomarker Branch, Research Institute, National Cancer Center, Goyang, 10408 Republic of Korea.

Background: Pancreatic cancer (PC) and biliary tract cancer (BTC) are highly aggressive cancers, characterized by their rarity, difficulty in diagnosis, and overall poor prognosis. Diagnosis of PC and BTC is complex and is made using a combination of appropriate clinical suspicion, imaging and endoscopic techniques, and cytopathological examination. However, the late-stage detection and poor prognosis of this tumor have led to an urgent need for biomarkers for early and/or predictive diagnosis and improved personalized treatments. Read More

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http://dx.doi.org/10.1007/s13167-018-0147-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107458PMC
September 2018
10 Reads

Liquid biopsy and multiparametric analysis in management of liver malignancies: new concepts of the patient stratification and prognostic approach.

EPMA J 2018 Sep 17;9(3):271-285. Epub 2018 Aug 17.

7Interventional Radiology, Department of Radiology, New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY USA.

Background: The annually recorded incidence of primary hepatic carcinomas has significantly increased over the past two decades accounting for over 800 thousand of annual deaths caused by hepatocellular carcinoma (HCC) alone globally. Further, secondary liver malignancies are much more widespread compared to primary hepatic carcinomas: almost all solid malignancies are able to metastasise into the liver. The primary tumours most frequently metastasising to the liver are breast followed by colorectal carcinomas. Read More

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http://link.springer.com/10.1007/s13167-018-0146-6
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http://dx.doi.org/10.1007/s13167-018-0146-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107456PMC
September 2018
11 Reads

Current approaches in the clinical management of pregnancy-associated breast cancer-pros and cons.

EPMA J 2018 Sep 24;9(3):257-270. Epub 2018 Jun 24.

1Department of Obstetrics and Gynaecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin University Hospital, Martin, Slovak Republic.

Malignancies are one of the leading causes of mortality in women during their reproductive life. Treatment of gynecological malignant tumors during pregnancy is possible but not simple, since it creates a conflict between care of the mother and the fetus. BC is the most prevalent malignancy diagnosed in pregnancy, ranking up to 21% of all pregnancy-related malignancies. Read More

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http://link.springer.com/10.1007/s13167-018-0139-5
Publisher Site
http://dx.doi.org/10.1007/s13167-018-0139-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107452PMC
September 2018
16 Reads

Neuromyelitis optica spectrum disorders and pregnancy: relapse-preventive measures and personalized treatment strategies.

EPMA J 2018 Sep 10;9(3):249-256. Epub 2018 Aug 10.

NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany.

Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune inflammatory diseases of the central nervous system that predominately affect women. Some of these patients are of childbearing age at NMOSD onset. This study reviews, on the one hand, the role NMOSD play in fertility, pregnancy complications and pregnancy outcome, and on the other, the effect of pregnancy on NMOSD disease course and treatment options available during pregnancy. Read More

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http://dx.doi.org/10.1007/s13167-018-0143-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107451PMC
September 2018
7 Reads

A new non-invasive diagnostic tool in coronary artery disease: artificial intelligence as an essential element of predictive, preventive, and personalized medicine.

EPMA J 2018 Sep 16;9(3):235-247. Epub 2018 Aug 16.

5Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Background: Known coronary artery disease (CAD) risk scores (e.g., Framingham) estimate the CAD-related event risk rather than presence/absence of CAD. Read More

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http://dx.doi.org/10.1007/s13167-018-0142-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107459PMC
September 2018
15 Reads

Biorepository and integrative genomics initiative: designing and implementing a preliminary platform for predictive, preventive and personalized medicine at a pediatric hospital in a historically disadvantaged community in the USA.

EPMA J 2018 Sep 2;9(3):225-234. Epub 2018 Aug 2.

4Department of Pediatrics, University of Tennessee Health Science Center, Center for Innate Immunity Translational Research, Children's Foundation Research Institute at Le Bonheur Children's Hospital, 50 N Dunlap, Room 365R, Memphis, TN 38103 USA.

Current healthcare is evolving to emphasize cost-effective care by leveraging results and outcomes of genomic and other advanced research efforts in clinical care and preventive health planning. Through a collaborative effort between the University of Tennessee Health Science Center (UTHSC) and Le Bonheur Children's Hospital (LBCH), the Biorepository and Integrative Genomics (BIG) Initiative was established to set up a pediatric-based DNA biorepository that can serve as a foundation for successful development of delivery platforms for predictive, preventive, and personalized medical services in Memphis, Tennessee, a historically disadvantaged community in the USA. In this paper, we describe the steps that were followed to establish the biorepository. Read More

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http://dx.doi.org/10.1007/s13167-018-0141-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107450PMC
September 2018
8 Reads

Specific properties of probiotic strains: relevance and benefits for the host.

EPMA J 2018 Jun 13;9(2):205-223. Epub 2018 Apr 13.

1Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Zabolotny str., 154, Kyiv, 03143 Ukraine.

Background: Probiotics have tremendous potential to develop healthy diets, treatment, and prevention. Investigation of in vitro cultural properties of health-promoting microorganisms like lactic acid bacteria (LAB) and bifidobacteria is crucial to select probiotic strains for treatments based on gut microbiota modulation to justify individualized and personalized approach for nutrition and prevention of variety of diseases. The was to study the biological properties of LAB and bifidobacteria probiotic strains, namely adhesive properties; resistance to antibiotics; and biological fluids (gastric juice, bile, pancreatic enzymes), and to overview the literature in the field. Read More

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http://dx.doi.org/10.1007/s13167-018-0132-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972142PMC
June 2018
25 Reads

Pathology-specific molecular profiles of saliva in patients with multiple dental caries-potential application for predictive, preventive and personalised medical services.

EPMA J 2018 Jun 25;9(2):195-203. Epub 2018 Apr 25.

3Australian Synchrotron (Synchrotron Light Source Australia Pty LTD), 800 Blackburn Rd, Clayton, VIC 3168 Australia.

Background: Improving the quality of life is part of the global agenda. The focus is predominantly on prevention of socially significant diseases. Combating dental caries-related diseases is a top priority as it has a huge impact on people's social lives. Read More

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http://dx.doi.org/10.1007/s13167-018-0135-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972136PMC
June 2018
13 Reads

The influence of mothers' oral health behaviour and perception thereof on the dental health of their children.

EPMA J 2018 Jun 26;9(2):187-193. Epub 2018 Apr 26.

1Institute of Dentistry, University of Tartu, Raekoja plats 6, 51003 Tartu, Estonia.

Objective: The study aims to investigate how mothers' oral health behaviour and perception thereof influence the dental health in their children.

Methods: A total of 556 Vietnamese mother-child pairs participated in the current study. Mothers self-reported their oral status and oral health behaviour and perception. Read More

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http://dx.doi.org/10.1007/s13167-018-0134-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972135PMC
June 2018
3 Reads

Premenopausal breast cancer: potential clinical utility of a multi-omics based machine learning approach for patient stratification.

EPMA J 2018 Jun 11;9(2):175-186. Epub 2018 Apr 11.

2Radiological Clinic, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.

Background: The breast cancer (BC) epidemic is a multifactorial disease attributed to the early twenty-first century: about two million of new cases and half a million deaths are registered annually worldwide. New trends are emerging now: on the one hand, with respect to the geographical BC prevalence and, on the other hand, with respect to the age distribution. Recent statistics demonstrate that young populations are getting more and more affected by BC in both Eastern and Western countries. Read More

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http://dx.doi.org/10.1007/s13167-018-0131-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972143PMC
June 2018
20 Reads

Novel concept to guide systolic heart failure medication by repeated biomarker testing-results from TIME-CHF in context of predictive, preventive, and personalized medicine.

EPMA J 2018 Jun 13;9(2):161-173. Epub 2018 May 13.

2Department of Cardiology, Maastricht University Medical Center, Maastricht, the Netherlands.

Background: It is uncertain whether repeated measurements of a multi-target biomarker panel may help to personalize medical heart failure (HF) therapy to improve outcome in chronic HF.

Methods: This analysis included 499 patients from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF), aged ≥ 60 years, LVEF ≤ 45%, and NYHA ≥ II, who had repeated clinical visits within 19 months follow-up. The interaction between repeated measurements of biomarkers and treatment effects of loop diuretics, spironolactone, β-blockers, and renin-angiotensin system (RAS) inhibitors on risk of HF hospitalization or death was investigated in a hypothesis-generating analysis. Read More

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http://dx.doi.org/10.1007/s13167-018-0137-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972133PMC
June 2018
37 Reads

Mental stress as consequence and cause of vision loss: the dawn of psychosomatic ophthalmology for preventive and personalized medicine.

EPMA J 2018 Jun 9;9(2):133-160. Epub 2018 May 9.

Berlin Institute of Health (BIH), Institute of Medical Psychology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

The loss of vision after damage to the retina, optic nerve, or brain has often grave consequences in everyday life such as problems with recognizing faces, reading, or mobility. Because vision loss is considered to be irreversible and often progressive, patients experience continuous mental stress due to worries, anxiety, or fear with secondary consequences such as depression and social isolation. While prolonged mental stress is clearly a of vision loss, it may also aggravate the situation. Read More

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http://dx.doi.org/10.1007/s13167-018-0136-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972137PMC
June 2018
11 Reads

Diabetes care in figures: current pitfalls and future scenario.

EPMA J 2018 Jun 22;9(2):125-131. Epub 2018 May 22.

3Radiological Clinic, Rheinische Friedrich-Wilhelms-Universität Bonn, Sigmund-Freud-Str 25, 53105 Bonn, Germany.

Diabetes mellitus (DM) epidemic-on a global scale-is a major and snowballing threat to public health, healthcare systems and economy, due to the cascade of pathologies triggered in a long-term manner after the DM manifestation. There are remarkable differences in the geographic disease spread and acceleration of an increasing DM prevalence recorded. Specifically, the highest initial prevalence of DM was recorded in the Eastern-Mediterranean region in 1980 followed by the highest acceleration of the epidemic characterised by 0. Read More

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http://dx.doi.org/10.1007/s13167-018-0133-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972141PMC
June 2018
18 Reads

Preventive, predictive, and personalized medicine for effective and affordable cancer care.

EPMA J 2018 Jun 26;9(2):113-123. Epub 2018 Mar 26.

Caris Life Sciences, St. Jakobsstrasse 199, 4052 Basel, Switzerland.

Preventive, predictive, and personalized medicine (PPPM) has created a wealth of new opportunities but added also new complexities and challenges. The European Cancer Prevention Organization already embraced unanimously molecular biology for primary and secondary prevention. The rapidly exploding genomic language and complexity of methods face oncologists with exponentially growing knowledge they need to assess and apply. Read More

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http://dx.doi.org/10.1007/s13167-018-0130-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972138PMC
June 2018
18 Reads

Implementation of personalized medicine in Central-Eastern Europe: pitfalls and potentials based on citizen's attitude.

EPMA J 2018 Mar 9;9(1):103-112. Epub 2018 Feb 9.

1Institute of Genomic Medicine and Rare Disorders, Semmelweis University, Tomo Street 25-29, Budapest, 1083 Hungary.

Objective: Next-generation sequencing is increasingly utilized worldwide as a research and diagnostic tool and is anticipated to be implemented into everyday clinical practice. Since Central-Eastern European attitude toward genetic testing, especially broad genetic testing, is not well known, we performed a survey on this issue among Hungarian participants.

Methods: A self-administered questionnaire was distributed among patients and patient relatives at our neurogenetic outpatient clinic. Read More

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http://dx.doi.org/10.1007/s13167-017-0125-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833891PMC
March 2018
14 Reads

The crucial role of multiomic approach in cancer research and clinically relevant outcomes.

EPMA J 2018 Mar 21;9(1):77-102. Epub 2018 Feb 21.

1Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008 People's Republic of China.

Cancer with heavily economic and social burden is the hot point in the field of medical research. Some remarkable achievements have been made; however, the exact mechanisms of tumor initiation and development remain unclear. Cancer is a complex, whole-body disease that involves multiple abnormalities in the levels of DNA, RNA, protein, metabolite and medical imaging. Read More

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http://dx.doi.org/10.1007/s13167-018-0128-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833337PMC
March 2018
6 Reads

High regenerative capacity of the liver and irreversible injury of male reproductive system in carbon tetrachloride-induced liver fibrosis rat model.

EPMA J 2018 Mar 11;9(1):59-75. Epub 2017 Oct 11.

3Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Zabolotny str., 150, Kyiv, 03143 Ukraine.

Background: Liver fibrosis (LF) is a chronic disease, associated with many collateral diseases including reproductive dysfunction. Although the normal liver has a large regenerative capacity the complications of LF could be severe and irreversible. Hormone and sex-related issues of LF development and interactions with male reproductive have not been finally studied. Read More

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http://dx.doi.org/10.1007/s13167-017-0115-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833895PMC
March 2018
9 Reads

Clinical and laboratory evaluation of microstructural changes in the physical, mechanical and chemical properties of dental filling materials under the influence of an electromagnetic field.

EPMA J 2018 Mar 21;9(1):47-58. Epub 2018 Feb 21.

Dentistry Faculty, The Department of Hospital Dentistry, Voronezh N.N. Burdenko State Medical University, Voronezh, Russia.

Restorative filling materials used for dental caries prevention and treatment consist of various components including monomers or oligomers, which play a significant role in forming the main structure of these materials, as well as in characterising their physical, mechanical and chemical properties. The necessity for the development and improvement of structural characteristics of polymeric dental filling materials intended for caries prevention and their life duration increase served as the initiating factor of our research. According to the research purpose and challenges, we studied the changes in the physical, mechanical and chemical properties of composite filling materials with and without electromagnetic field influence. Read More

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http://link.springer.com/10.1007/s13167-018-0126-x
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http://dx.doi.org/10.1007/s13167-018-0126-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833897PMC
March 2018
9 Reads

Heart rate variability: the comparison between high tension and normal tension glaucoma.

EPMA J 2018 Mar 22;9(1):35-45. Epub 2018 Feb 22.

Science Center of Radiation and Chemical Safety and Hygiene, Medical and Biological Agency, Moscow, Russian Federation.

Relevance: Vascular factors may be involved in the development of both high tension glaucoma (HTG) and normal tension (NTG) glaucoma; however, they may be not exactly the same. Autonomic dysfunction characterized by heart rate variability (HRV) is one of the possible reasons of decrease in mean ocular perfusion pressure (MOPP).

Purpose: To compare the shift of the HRV parameters in NTG and HTG patients after a cold provocation test (CPT). Read More

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http://dx.doi.org/10.1007/s13167-017-0124-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833892PMC
March 2018
5 Reads

Optical coherence tomography in neuromyelitis optica spectrum disorders: potential advantages for individualized monitoring of progression and therapy.

EPMA J 2018 Mar 22;9(1):21-33. Epub 2017 Dec 22.

NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany.

Neuromyelitis optica spectrum disorders (NMOSD) are mostly relapsing inflammatory disorders of the central nervous system (CNS). Optic neuritis (ON) is the first NMOSD-related clinical event in 55% of the patients, which causes damage to the optic nerve and leads to visual impairment. Retinal optical coherence tomography (OCT) has emerged as a promising method for diagnosis of NMOSD and potential individual monitoring of disease course and severity. Read More

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http://dx.doi.org/10.1007/s13167-017-0123-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833887PMC
March 2018
7 Reads

Individualised patient profile: clinical utility of Flammer syndrome phenotype and general lessons for predictive, preventive and personalised medicine.

EPMA J 2018 Mar 22;9(1):15-20. Epub 2018 Feb 22.

4Department of Ophthalmology, University of Basel, Basel, Switzerland.

This case report introduces a female patient, who since her teenager age evidently suffers from Flammer syndrome (FS) as the clearly defined sub-optimal health condition. Further, the patient has experienced collateral pathological conditions which primarily might be linked to the family (genetic) predisposition, but the development of which could be synergistically promoted by the FS-phenotype. The facts are thoroughly analysed and consequent hypotheses are presented, which are indicative for highly desirable predictive diagnostics and targeted preventive measures to be created based on the accurate interpretation of the individualised patient profile. Read More

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http://dx.doi.org/10.1007/s13167-018-0127-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833886PMC
March 2018
9 Reads

Pregnancy-associated breast cancer: the risky status quo and new concepts of predictive medicine.

EPMA J 2018 Mar 8;9(1):1-13. Epub 2018 Feb 8.

4Radiological Clinic, Rheinische Friedrich-Wilhelms-Universität Bonn, Sigmund-Freud-Str 25, 53105 Bonn, Germany.

The paper is motivated by severe concerns regarding currently applied care of the pregnancy-associated breast cancer (PABC) characterised by particularly poor outcomes of the disease. Psychological and ethical aspects play a crucial role in PABC: the highest priority not to damage the foetus significantly complicates any treatment generally, and it is quite usual that patients disclaim undergoing any breast cancer treatment during pregnancy. Although, due to global demographic trends, PABC is far from appearing rarely now, severe societal and economic consequences of the disease are still neglected by currently applied reactive medical approach. Read More

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http://dx.doi.org/10.1007/s13167-018-0129-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833893PMC
March 2018
6 Reads

PCSK9 signaling pathways and their potential importance in clinical practice.

EPMA J 2017 Dec 14;8(4):391-402. Epub 2017 Aug 14.

Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium, Medicum in Bydgoszcz, Nicolaus Copernicus University, 85-090 Bydgoszcz, Poland.

In the following review, authors described the structure and biochemical pathways of PCSK9, its involvement in LDL metabolism, as well as significances of proprotein convertase subtilisin/kexin type 9 targeted treatment. PCSK9 is a proprotein convertase, which plays a crucial role in LDL receptor metabolism. Transcription and translation of PCSK9 is controlled by different nuclear factors, such as, SREBP and HNF1α. Read More

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http://dx.doi.org/10.1007/s13167-017-0106-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700013PMC
December 2017
5 Reads

Efficacy of Fenugreek-based bionanocomposite on renal dysfunction and endogenous intoxication in high-calorie diet-induced obesity rat model-comparative study.

EPMA J 2017 Dec 16;8(4):377-390. Epub 2017 Jun 16.

Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Zabolotny Str., 154, Kyiv, 03143 Ukraine.

Background: Worldwide obesity spread is a global health problem and needs to be further studied. Co-morbidities of obesity include insulin resistance, diabetes mellitus type 2, and dyslipidemia, which are the most frequent contributing factors for metabolic syndrome (MetS), as well as non-alcoholic fatty liver disease and chronic kidney disease. The aim was to study renal function and endogenous intoxication panel on high-calorie diet-induced obesity rat model and perform comparative study of the treatment efficacy of Fenugreek-based bionanocomposite vs antiobesogenic drugs (Orlistat). Read More

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http://dx.doi.org/10.1007/s13167-017-0098-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700020PMC
December 2017
20 Reads
2 Citations

Comparative study of probiotic effects of and strains on cholesterol levels, liver morphology and the gut microbiota in obese mice.

EPMA J 2017 Dec 10;8(4):357-376. Epub 2017 Oct 10.

Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Zabolotny Str., 154, Kyiv, 03143 Ukraine.

Background: Microbiome-modulating interventions are promising for treatment and prevention of metabolic syndrome. The number of probiotic strains demonstrated ability to decrease cholesterol level in vivo, however, it was poorly confirmed in a clinical setting. The aim was to study the effects of IMV B-7279, IMV B-7280, VKL and VKB separately and in various compositions on the level of serum cholesterol, gut microbiota contents and liver morphology on a high-calorie-induced obesity model in BALB/c mice. Read More

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http://dx.doi.org/10.1007/s13167-017-0117-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700021PMC
December 2017
43 Reads
2 Citations

Incorporation of suboptimal health status as a potential risk assessment for type II diabetes mellitus: a case-control study in a Ghanaian population.

EPMA J 2017 Dec 18;8(4):345-355. Epub 2017 Oct 18.

School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Perth, WA 6027 Australia.

Due to a paradigm shift in lifestyles, there is growing concern that type 2 diabetes mellitus (T2DM) will reach epidemic proportions in Ghana. However, specific characteristics of the disease are under explored in this region. More challenging are those yet to be diagnosed or who complain of poor health in the absence of a diagnosed disease-suboptimal health status (SHS). Read More

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http://dx.doi.org/10.1007/s13167-017-0119-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700018PMC
December 2017
8 Reads

Retinal venous pressure measurements in patients with Flammer syndrome and metabolic syndrome.

EPMA J 2017 Dec 5;8(4):339-344. Epub 2017 Sep 5.

Department of Ophthalmology, University of Basel, Mittlere Str 91, 4031 Basel, Switzerland.

Background: The purpose of this research is to analyze retinal venous pressure (RVP) of both eyes of patients who visited a Swiss ophthalmic practice and compare values among the following groups of patients with primary open-angle glaucoma (POAG), Flammer syndrome (FS), and metabolic syndrome (MetS).

Methods: RVP was measured in both eyes of all patients who visited a Swiss ophthalmic practice during March 2016 till November 2016, and the results were analyzed retrospectively. All measurements were performed by one physician by means of ophthalmodynamometry. Read More

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http://dx.doi.org/10.1007/s13167-017-0105-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700036PMC
December 2017
12 Reads

The potential relationship between Flammer and Sjögren syndromes: the chime of dysfunction.

EPMA J 2017 Dec 14;8(4):333-338. Epub 2017 Aug 14.

Radiological clinic, Rheinische Friedrich-Wilhelms-University of Bonn, Sigmund-Freud-Str 25, D-53105 Bonn, Germany.

Flammer syndrome (FS) is a term to blanket a cluster of vascular and nonvascular signs and symptoms linked to primary vascular dysregulation (PVD), increased sensitivity to various stimuli (stress, drugs, etc.) and altered sense regulation such as pain, smell and thirst perception. On one hand, disruption of blood barrier and homeostasis of the body are the main targets of vascular irregularity. Read More

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http://dx.doi.org/10.1007/s13167-017-0107-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700012PMC
December 2017
10 Reads

Diseases potentially related to Flammer syndrome.

EPMA J 2017 Dec 13;8(4):327-332. Epub 2017 Sep 13.

Eye Clinic Wittenbergplatz, Berlin, Germany.

Flammer syndrome (FS) is a prevalent and mostly benign condition. Subjects with FS seem to have a good life expectancy. Nevertheless, FS subjects are at increased risk for certain diseases, mainly when they are challenged by psychological stress or other stimuli such as coldness. Read More

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http://dx.doi.org/10.1007/s13167-017-0116-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700007PMC
December 2017
11 Reads

Vitamin D in the prevention, prediction and treatment of neurodegenerative and neuroinflammatory diseases.

EPMA J 2017 Dec 15;8(4):313-325. Epub 2017 Nov 15.

Charité - Universitätsmedizin, corporate member of Freie Universität Berlin, Humboldt- Universitäts zu Berlin, and Berlin Institute of Health, Neurocure Cluster of Excellence, and Multiple Sclerosis Center Hennigsdorf, Oberhavel Clinics, Berlin, Germany.

Vitamin D research has gained increased attention in recent times due to its roles beyond bone health and calcium homeostasis, such as immunomodulation. In some parts of the brain and on immune cells, vitamin D hydroxylating enzymes and its receptors are located. Epidemiological evidence demonstrates that deficiency of Vitamin D is relevant for disease risk and course in multiple sclerosis (MS) and presumably also in neuromyelitis optica spectrum disorders (NMOSD), Parkinson's disease (PD), and Alzheimer's disease (AD). Read More

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http://dx.doi.org/10.1007/s13167-017-0120-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700019PMC
December 2017
11 Reads

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

EPMA J 2017 Sep 20;8(3):295-311. Epub 2017 Jul 20.

Department of General Surgery and Surgical Specialties, Medical School, Surgical Clinic, University of Modena and Reggio Emilia, Modena, Italy.

Autoimmune diseases, including multiple sclerosis and type 1 diabetes mellitus, affect about 5% of the worldwide population. In the last decade, reports have accumulated on various autoimmune disorders, such as idiopathic thrombocytopenia purpura, myopericarditis, primary ovarian failure, and systemic lupus erythematosus (SLE), following vaccination. In this review, we discuss the possible underlying mechanisms of autoimmune reactions following vaccinations and review cases of autoimmune diseases that have been correlated with vaccination. Read More

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http://link.springer.com/10.1007/s13167-017-0101-y
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http://dx.doi.org/10.1007/s13167-017-0101-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607155PMC
September 2017
16 Reads

Diffusion tensor imaging for multilevel assessment of the visual pathway: possibilities for personalized outcome prediction in autoimmune disorders of the central nervous system.

EPMA J 2017 Sep 25;8(3):279-294. Epub 2017 Jul 25.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Neurocure Cluster of Excellence, NeuroCure Clinical Research Center, Charitéplatz 1, D-10117 Berlin, Germany.

The afferent visual pathway represents the most frequently affected white matter pathway in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). Diffusion tensor imaging (DTI) can reveal microstructural or non-overt brain tissue damage and quantify pathological processes. DTI facilitates the reconstruction of major white matter fiber tracts allowing for the assessment of structure-function and damage-dysfunction relationships In this review, we outline DTI studies investigating the afferent visual pathway in idiopathic optic neuritis (ON), NMOSD, and MS. Read More

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http://dx.doi.org/10.1007/s13167-017-0102-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607151PMC
September 2017
15 Reads

Qualitative analysis of Parkinson's disease information on social media: the case of YouTube™.

EPMA J 2017 Sep 23;8(3):273-277. Epub 2017 Aug 23.

Canterbury District Health Board, Christchurch, New Zealand.

Introduction: There is a paucity of data pertaining to the usefulness of information presented on social media platforms on chronic neuropsychiatric conditions such as Parkinson's disease (PD). The aim of this study was to examine the quality of YouTube™ videos that deliver general information on PD and the availability and design of instructional videos addressing the caregiving role in PD.

Methods: YouTube™ was searched using the keyword "Parkinson's disease" for relevant videos. Read More

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http://dx.doi.org/10.1007/s13167-017-0113-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609804PMC
September 2017
19 Reads

The BSSG rat model of Parkinson's disease: progressing towards a valid, predictive model of disease.

EPMA J 2017 Sep 4;8(3):261-271. Epub 2017 Sep 4.

Neurodyn Life Sciences, NRC Building, 550 University Ave., Charlottetown, PE C1A 4P3 Canada.

Abstract: Parkinson's disease (PD) is a neurodegenerative disorder, classically considered a movement disorder. A great deal is known about the anatomical connections and neuropathology and pharmacological changes of PD, as they relate to the loss of dopaminergic function and the appearance of cardinal motor symptoms. Our understanding of the role of dopamine in PD has led to the development of effective pharmacological treatments of the motor symptoms in the form of dopamine replacement therapy using levodopa and dopaminergic agonists. Read More

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http://dx.doi.org/10.1007/s13167-017-0114-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613678PMC
September 2017
22 Reads

Specific protein biomarker patterns for Alzheimer's disease: improved diagnostics in progress.

Authors:
Illana Gozes

EPMA J 2017 Sep 4;8(3):255-259. Epub 2017 Sep 4.

The Lily and Avraham Gildor Chair for the Investigation of Growth Factors, Elton Laboratory for Neuroendocrinology, Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Adams Super Center for Brain Studies and Sagol School of Neuroscience, Tel Aviv University, 69978 Tel Aviv, Israel.

This short review looks at Alzheimer's disease (AD) diagnosis through my own point of view, going from imaging through cerebrospinal fluid to blood proteins. Over the last couple of years, we have published two papers targeted at Alzheimer's diagnosis. In one paper, we took an approach of selecting a specific target, namely, activity-dependent neuroprotective protein (ADNP), and our results tightened the association of ADNP blood expression with intelligence. Read More

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http://dx.doi.org/10.1007/s13167-017-0110-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607150PMC
September 2017
5 Reads

Progressive changes in hippocampal cytoarchitecture in a neurodevelopmental rat model of epilepsy: implications for understanding presymptomatic epileptogenesis, predictive diagnosis, and targeted treatments.

EPMA J 2017 Sep 29;8(3):247-254. Epub 2017 Aug 29.

Department of Biomedical Sciences, University of Prince Edward Island, 550 University Avenue, Charlottetown, PEI C1A 4P3 Canada.

Epilepsies affect about 4% of the population and are frequently characterized by a prolonged "silent" period before the onset of spontaneous seizures. Most current animal models of epilepsy either involve acute seizure induction or kindling protocols that induce repetitive seizures. We have developed a rat model of epilepsy that is characterized by a slowly progressing series of behavioral abnormalities prior to the onset of behavioral seizures. Read More

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http://dx.doi.org/10.1007/s13167-017-0111-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612338PMC
September 2017
9 Reads

Perceived social support as a moderator between negative life events and depression in adolescence: implications for prediction and targeted prevention.

EPMA J 2017 Sep 23;8(3):237-245. Epub 2017 Jun 23.

Faculty of Medical Science, Goce Delcev University, Ul. Krste Misirkov, bb, 2000 Stip, Republic of Macedonia.

Aim And Background: The role of the perceived social support in prevention of depression in adolescence still remains an insufficiently explored problem. By integrating the results of the previous studies of moderator role of perceived social support between negative life events and depression in adolescence we set up two goals. One is to determine whether perceived social support has moderator role in the sample consisted of clinical, subclinical, and control respondents. Read More

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http://dx.doi.org/10.1007/s13167-017-0095-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607153PMC
September 2017
28 Reads

What California sea lions exposed to domoic acid might teach us about autism: lessons for predictive and preventive medicine.

EPMA J 2017 Sep 12;8(3):229-235. Epub 2017 Sep 12.

Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239 USA.

Autism spectrum disorder (ASD) shares many biological and behavioral similarities with the deleterious effects of domoic acid (DA) exposure. DA is produced by marine algae and most commonly by species of . Humans and marine mammals can be exposed to DA when they consume whole fish or shellfish. Read More

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http://dx.doi.org/10.1007/s13167-017-0118-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607054PMC
September 2017
25 Reads