2,760 results match your criteria The Clinical journal of pain[Journal]


Exposure to Cold Unmasks Potential Biomarkers of Fibromyalgia Syndrome Reflecting Insufficient Sympathetic Responses to Stress.

Clin J Pain 2019 Feb 12. Epub 2019 Feb 12.

Dept. Veterinary and Biomedical Sciences, University of Minnesota, St. Paul MN.

Objectives: Fibromyalgia syndrome (FMS) is a chronically painful condition whose symptoms are widely reported to be exacerbated by stress. We hypothesized that female patients with FMS differ from healthy female controls in their sympathetic responses, a fact that may unmask important biomarkers and factors that contribute to the etiology of FMS.

Methods: In a pilot study, blood pressure (BP), skin temperature, thermogenic activity, circulating glucose, and pain sensitivity of 13 patients and 11 controls at room temperature (24°C) were compared to that after exposure to cold (19°C). Read More

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http://dx.doi.org/10.1097/AJP.0000000000000695DOI Listing
February 2019
1 Read

Analgesic Potentials of Preoperative Oral Pregabalin, Intravenous Magnesium Sulfate, and their Combination in Acute Postthoracotomy Pain.

Clin J Pain 2019 Mar;35(3):247-251

Department of Anesthesiology and Pain Relief, National Cancer Institute, Cairo University, Cairo.

Objectives: The objective of this study was to investigate the effects of the preoperative combination of oral Pregabalin and intravenous (IV) magnesium sulfate as analgesic adjuvants in postthoracotomy pain.

Patients And Methods: One hundred twenty patients with American Society of Anesthesiologists physical status II were allocated randomly into 1 of 4 groups. Group MP received 300 mg pregabalin orally and an IV infusion of magnesium sulfate 50 mg/kg mixed with 200 mL normal saline (NS); group P received 300 mg pregabalin orally and 200 mL NS infusion; group M received an IV infusion of magnesium sulfate 50 mg/kg mixed with 200 mL NS and a placebo capsule; and group C received placebo capsule and an IV infusion of 200 mL NS. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000673DOI Listing

Posttraumatic Stress Symptoms Mediate the Effects of Trauma Exposure on Clinical Indicators of Central Sensitization in Patients With Chronic Pain.

Clin J Pain 2019 Feb 5. Epub 2019 Feb 5.

Department of Psychology, The Ohio State University.

Objective: Evidence supports high rates of co-occurrence of posttraumatic stress disorder (PTSD) and chronic pain disorders involving central sensitization (CS). The nature of this relationship, however, remains relatively unexplored. In this study, we aimed to (1) assess how both trauma exposure and current PTSD symptoms are related to clinical manifestations of CS, and (2) test whether PTSD symptoms explain the relationship between trauma exposure and CS. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000689DOI Listing
February 2019
1 Read

Changes in the Organization of the Secondary Somatosensory Cortex While Processing Lumbar Proprioception and the Relationship With Sensorimotor Control in Low Back Pain.

Clin J Pain 2019 Feb 5. Epub 2019 Feb 5.

KU Leuven Department of Rehabilitation Sciences, Tervuursevest 101, box 1501, 3001 Leuven, Belgium.

Objectives: Patients with non-specific low back pain (NSLBP) rely more on ankle compared to lower back proprioception during standing, perform sit-to-stand-to-sit (STSTS) movements slower, and exhibit perceptual impairments at the lower back. However, no studies investigated whether these sensorimotor impairments relate to a reorganization of the primary and secondary somatosensory cortices (S1 and S2) and primary motor cortex (M1) during proprioceptive processing.

Methods: Proprioceptive stimuli were applied at lower back and ankle muscles during functional magnetic resonance imaging (fMRI) in 15 patients with NSLBP and 13 controls. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000692DOI Listing
February 2019

Pain Catastrophizing and Function In Individuals With Chronic Musculoskeletal Pain: A Systematic Review and Meta-Analysis.

Clin J Pain 2019 Mar;35(3):279-293

Department of Physiotherapy.

Objectives: Pain catastrophizing (PC) is the most consistent psychosocial factor predicting of adjustment to chronic pain and may contribute to the development and long-term maintenance of chronic pain. The aim of this review was systematically review and critically appraise the concurrent and longitudinal associations between PC and both pain intensity and disability in individuals with chronic musculoskeletal pain (CMP).

Materials And Methods: An electronic search of PubMed, Scopus, AMED, CINAHL, PsycINFO, and PubPsych databases, as well as gray literature, was undertaken from inception until September 2018. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000676DOI Listing
March 2019
1 Read

Telehealth Therapy Effects of Nurses and Mental Health Professionals From 2 Randomized Controlled Trials for Chronic Back Pain.

Clin J Pain 2019 Jan 18. Epub 2019 Jan 18.

VA San Diego Healthcare System.

Objective: To compare the efficacy of mental health professional versus primary care nurse-delivered telehealth cognitive-behavioral therapy (CBT) and supportive care (SC) treatments for chronic low back pain, using data from 2 separate randomized controlled trials. Both trials were completed in the same hospital and used the same study design, research team, and outcome measures.

Materials And Methods: Participants from Study 1 (Mental Health Professional Study) (N=66; 2007 to 2011) and Study 2 (Nursing Study) (N=61; 2012 to 2016) were patients with chronic low back pain (≥4/10 intensity) randomized to either an 8-week CBT or an SC telehealth condition matched for contact frequency, format, and time. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000678DOI Listing
January 2019
6 Reads

TRPA1 Sensitization Produces Hyperalgesia to Heat but not to Cold Stimuli in Human Volunteers.

Clin J Pain 2019 Jan 18. Epub 2019 Jan 18.

Institute of Clinical Pharmacology, Goethe-University.

Background: Transient receptor potential ion channels play a role in thermal hyperalgesia and are among targets of novel analgesics. However, a role of TRPA1 in either heat or cold hyperalgesia is controversial. In this study, changes in thermal sensitivity were assessed following topical application of a specific sensitizer of TRPA1 and compared with the effects of sensitizers of TRPV1 and TRPM8. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000677DOI Listing
January 2019
4 Reads

Variables Associated with the Use of Prophylactic Amitriptyline Treatment in Patients with Tension Type Headache.

Clin J Pain 2019 Jan 11. Epub 2019 Jan 11.

Department Physical Therapy, Occupational Therapy, Rehabilitation, and Physical Medicine, University Rey Juan Carlos, Alcorcón, Spain.

Objective: To investigate differences in clinical, psychological and psychophysical outcomes according to use of prophylactic medication (amitriptyline) in tension type headache (TTH).

Methods: One hundred and seventy-three (n=173) individuals with TTH participated. Headache features and symptomatic medication intake were collected with a 4-weeks headache diary at baseline and at 6-months. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000685DOI Listing
January 2019
1 Read

Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated with Widespread Pressure Pain Sensitivity and Depression in Women with Chronic, but not Episodic, Tension Type Headache.

Clin J Pain 2019 Jan 4. Epub 2019 Jan 4.

Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, School of Medicine, Aalborg University, Aalborg, Denmark.

Objectives: The aims of this study were: 1, to investigate the association between the rs4680 Val158Met polymorphism in frequent episodic (FETTH) and chronic (CTTH) tension-type headache; and 2, to analyse the association between the rs4680 Val158Met polymorphism with clinical, psychological, or psychophysical variables.

Methods: Fifty women with FETTH, 50 with CTTH, and 50 matched healthy women participated. After amplifying Val158Met polymorphism by polymerase chain reaction, the genotype frequencies and allele distributions based on restriction fragment length polymorphism were assessed. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000684DOI Listing
January 2019
2 Reads

Multidisciplinary Treatment for Provoked Vestibulodynia: Treatment Trajectories, Predictors, and Moderators of Sexual Distress and Pain.

Clin J Pain 2019 Jan 4. Epub 2019 Jan 4.

Department of Obstetrics & Gynaecology, University of British Columbia, Vancouver, BC, Canada.

Objectives: Multidisciplinary treatment programs for provoked vestibulodynia (PVD) are recommended, yet few have been evaluated. This study examined women's symptom trajectories over time, as well as baseline demographic, psychosocial and pain characteristics as predictors/ moderators of sexual pain and distress following treatment at a clinic using multidisciplinary concurrent methods. We also examined the impact of baseline variables on the probability of having low sexual distress scores following treatment. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000682DOI Listing
January 2019
6 Reads

Effect of Local Anesthetic versus Botulinum Toxin-A Injections on Subjective for Myofascial Pain Disorders: A Systematic Review and Meta-analysis.

Clin J Pain 2018 Dec 26. Epub 2018 Dec 26.

Division of Physical Medicine and Rehabilitation, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Objective: Myofascial pain is a chronic pain disorder characterized by the presence of painful localized regions of stiff muscle and/or myofascial trigger points (MTrP). Intramuscular MTrP injections are considered first-line treatments for myofascial pain. Common injectates include local anesthetics and botulinum toxin-A (BTX-A). Read More

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http://dx.doi.org/10.1097/AJP.0000000000000681DOI Listing
December 2018
2 Reads
2.527 Impact Factor

Pre-collision Medical Diagnoses Predict Chronic Neck Pain Following Acute Whiplash-trauma.

Clin J Pain 2018 Dec 26. Epub 2018 Dec 26.

The Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus C, Denmark.

Objectives: The reason why some individuals develop chronic symptoms, whiplash-associated disorder, following whiplash trauma is poorly understood. We explored whether pre-collision pain-related diagnoses, medically unexplained symptoms and psychiatric diagnoses are related to whiplash-associated disorder.

Methods: A cohort of 719 individuals exposed to whiplash trauma and subsequently experiencing symptoms within 72 hours (whiplash-exposed cohort) and 3595 matched controls were included in this observational prospective study. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000683DOI Listing
December 2018
5 Reads
2.527 Impact Factor

Exploring the Role of Regional Anesthesia in the Treatment of the Burn Injured Patient: A Narrative Review of Current Literature.

Clin J Pain 2018 Dec 11. Epub 2018 Dec 11.

The University of Queensland, School of Nursing, Midwifery and Social Work, St Lucia, QLD, Australia, 4072.

Objectives: The review article was designed to assess the effectiveness of regional anesthesia, specifically peripheral nerve blocks, in the treatment of burn pain; with noting of clinical indications and contraindications for peripheral nerve block application, along with discussion of evidence-based analgesic strategies for providing improved, comprehensive burn pain management.

Methods: A search of relevant literature was performed using CINAHL, PubMed, EMBASE, Web of Science and SCOPUS with a publication date between January 2005 and December 2017.

Results: The search yielded ten results that met criteria. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000680DOI Listing
December 2018
3 Reads

The Psychological Predictors of Acute and Chronic Pain in Women Following Breast Cancer Surgery: A Systematic Review.

Clin J Pain 2019 Mar;35(3):261-271

School Psychological Sciences and Health, University of Strathclyde.

Objectives: Numerous psychological factors have been found to be associated with acute and chronic pain following breast cancer surgery. However, individual studies tend to be limited to a small number of predictors and many fail to employ prospective designs. This study aimed to identify a broader range of psychological predictors of acute and chronic pain following breast cancer surgery through a systematic review of relevant prospective studies. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000672DOI Listing
March 2019
1 Read

Analgesic Potentials of Preoperative Oral Pregabalin, Intravenous Magnesium Sulphate and their Combination in Acute Post-thoracotomy Pain.

Clin J Pain 2018 Nov 28. Epub 2018 Nov 28.

Anesthesiology and pain relief, National Cancer Institute, Cairo University, Egypt.

Objectives: To investigate the effects of the preoperative combination of oral pregabalin and intravenous magnesium sulphate as analgesic adjuvants in post thoracotomy pain.

Methods: One hundred and twenty patients with ASA physical status II were allocated randomly into one of four groups. Group MP received 300▒mg pregabalin orally and an intravenous (IV) infusion of magnesium sulphate 50▒mg/kg mixed with 200▒mL normal saline (NS); Group P received 300▒mg pregabalin orally and 200▒mL NS infusion; Group M received an IV infusion of magnesium sulphate 50▒mg/kg mixed with 200▒mL NS and a placebo capsule; and Group C received placebo capsule and an IV infusion of 200▒mL NS. Read More

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http://Insights.ovid.com/crossref?an=00002508-900000000-9887
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http://dx.doi.org/10.1097/AJP.0000000000000673DOI Listing
November 2018
13 Reads

Efficacy and Safety of Pregabalin in Neuropathic Pain Followed Spinal Cord Injury: A Review and Meta-Analysis of Randomized Controlled Trials.

Clin J Pain 2019 Mar;35(3):272-278

Department of Orthopaedics.

Objective: Pregabalin has been approved for the treatment of the neuropathic pain following spinal cord injury (SCI). We performed a systemic review and meta-analysis of randomized, controlled, multicenter trials to evaluate the efficacy and safety of pregabalin for SCI-induced neuropathic pain.

Materials And Methods: Research searching was performed in PubMed and EMBASE databases and the Cochrane library in May 2018. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000675DOI Listing
March 2019
3 Reads
2.527 Impact Factor

Cognitive Biases Toward Pain: Implications for a Neurocognitive Processing Perspective in Chronic Pain and its Interaction With Depression.

Clin J Pain 2019 Mar;35(3):252-260

Department of Medical Psychology and Medical Sociology, Faculty of Medicine, Ruhr-University of Bochum, Germany.

Objectives: Information-processing biases such as attentional, interpretation, and memory biases are supposed to play a role in the exacerbation and maintenance of chronic pain. Current research in the area of cognitive biases shows that all these biases seem to have an influence on attention to, interpretation of, and recall of pain and can lead to maladaptive strategies and the exacerbation of pain.

Methods: We conducted a narrative literature review, considering evidence extracted from various databases including PubMed, MEDLINE, Science Direct, and ProQuest. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000674DOI Listing
March 2019
10 Reads

Dexmedetomidine as an Adjuvant to Local Anesthetics in Transversus Abdominis Plane Block: A Systematic Review and Meta-analysis.

Clin J Pain 2018 Nov 20. Epub 2018 Nov 20.

Department of Anesthesiology, The Second Hospital of Jilin University, Changchun 130041, China.

Objectives: The objective of this meta-analysis was to evaluate the analgesic effects of dexmedetomidine (DEX) in transversus abdominis plane (TAP) blocks for abdominal surgery.

Methods: Electronic databases, including PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), Wan Fang, and the Cochrane Library , were conducted to collect the randomized controlled trials (RCTs) from inception to March 2018. RCTs investigating the impact of adding DEX to local anesthetics for TAP blocks were included in this analysis. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000671DOI Listing
November 2018
1 Read

The Multimodal Assessment Model of Pain: A Novel Framework for Further Integrating the Subjective Pain Experience Within Research and Practice.

Clin J Pain 2019 Mar;35(3):212-221

Department of Neural and Pain Sciences, School of Dentistry, and Center to Advance Chronic Pain Research, University of Maryland, Baltimore, MD.

Objectives: Pain assessment is enigmatic. Although clinicians and researchers must rely upon observations to evaluate pain, the personal experience of pain is fundamentally unobservable. This raises the question of how the inherent subjectivity of pain can and should be integrated within assessment. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000670DOI Listing
March 2019
14 Reads

Prognostic Factors for Physical Functioning After Multidisciplinary Rehabilitation in Patients With Chronic Musculoskeletal Pain: A Systematic Review and Meta-Analysis.

Clin J Pain 2019 Feb;35(2):148-173

Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet.

Objectives: This systematic review aimed to identify and evaluate prognostic factors for long-term (≥6 mo) physical functioning in patients with chronic musculoskeletal pain following multidisciplinary rehabilitation (MDR).

Materials And Methods: Electronic searches conducted in MEDLINE, PsycINFO, EMBASE, CINAHL, Web of Science, and Cochrane CENTRAL revealed 25 original research reports, published 1983-2016, (n=9436). Potential prognostic factors relating to initial pain and physical and psychological functioning were synthesized qualitatively and quantitatively in random effects meta-analyses. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343958PMC
February 2019
10 Reads

Whiplash Patients' Responses on the Impact of Events Scale-R: Congruent With Pain or PTSD Symptoms?

Clin J Pain 2019 Mar;35(3):229-237

Recover Injury Research Centre, The University of Queensland, Brisbane, Australia.

Objectives: Posttraumatic stress disorder (PTSD) symptoms are common among people with whiplash following a motor vehicle crash. The Impact of Events Scale-Revised (IES-R) screens for PTSD symptoms with psychologist referral recommended for above-threshold scores. Recent data indicate that PTSD symptoms post-whiplash may relate more to pain and disability than the crash itself. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000665DOI Listing
March 2019
15 Reads

Parent Factors are Associated With Pain and Activity Limitations in Youth With Acute Musculoskeletal Pain: A Cohort Study.

Clin J Pain 2019 Mar;35(3):222-228

Departments of Pediatrics.

Objectives: Biopsychosocial models emphasize the influence of parent/family factors on pediatric chronic pain. Little is known about how parent factors differ across the acute to chronic pain continuum, or contribute to youths' pain experience in the acute pain period. The purpose of the study was to describe parent factors in youth with acute musculoskeletal pain (n=84) compared with youth with chronic pain (n=60) and youth without pain (n=61). Read More

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http://Insights.ovid.com/crossref?an=00002508-900000000-9888
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http://dx.doi.org/10.1097/AJP.0000000000000668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367013PMC
March 2019
11 Reads

Clinical Reference Points for the Screen for Child Anxiety-related Disorders in 2 Investigations of Youth With Chronic Pain.

Clin J Pain 2019 Mar;35(3):238-246

Division of Behavioral Medicine and Clinical Psychology.

Objective: Anxiety is common in pediatric chronic pain and is related to a higher risk for poor outcomes; thus, there is a need for effective clinical screening methods to identify youth with chronic pain and co-occurring anxiety. The Screen for Child Anxiety-related Disorders (SCARED) is a validated measure that defines clinically significant anxiety using the traditional clinical cut-off, but in pain populations, may fail to screen in youth with subclinical anxiety that may also be at increased risk. Two studies aimed to devise a clinically meaningful approach to capture anxiety severity in pediatric chronic pain. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367022PMC
March 2019
9 Reads

The Impact of 3 Different Distraction Techniques on the Pain and Anxiety Levels of Children During Venipuncture: A Clinical Trial.

Clin J Pain 2019 Feb;35(2):140-147

Midwifery Department, Faculty of Health Sciences, Istanbul University, Istanbul, Turkey.

Objectives: Invasive procedures are important causes of pain and anxiety during hospitalization. This study aimed to evaluate the effect of 3 different distraction methods on the pain and anxiety levels of children during venipuncture.

Methods: This was a randomized controlled trial conducted with 180 children of 6 to 10 years of age; data were collected in the months of August to November 2016. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000666DOI Listing
February 2019
28 Reads

Predictors of Referral to a Pediatric Outpatient Chronic Pain Clinic.

Clin J Pain 2019 Mar;35(3):205-211

Department of Anesthesiology and Pain Medicine Nationwide Children's Hospital.

Objectives: The main objectives of this study were to retrospectively characterize the rate of referrals to an outpatient chronic pain clinic among adolescents with chronic pain, and to identify factors associated with referral.

Materials And Methods: Adolescents, 13 to 18 years of age seen in 2010 to 2015 at outpatient clinics associated with Nationwide Children's Hospital (NCH) and diagnosed with chronic pain were included if they lived near NCH and had not been previously referred to the NCH outpatient chronic pain clinic. Subsequent referrals to the pain clinic were tracked through December 2017 using a quality improvement database. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000664DOI Listing
March 2019
2 Reads

Clinical Overview and Considerations for the Management of Opioid-induced Constipation in Patients With Chronic Noncancer Pain.

Authors:
Eugene R Viscusi

Clin J Pain 2019 Feb;35(2):174-188

Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA.

Objectives: Opioid analgesics may be associated with chronic adverse effects, such as opioid-induced constipation (OIC). Available and emerging prescription medications for OIC in patients with chronic noncancer pain are described, including concerns and challenges associated with OIC management.

Methods: Narrative review. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343957PMC
February 2019
7 Reads

Sensory Modulation: An Important Piece of the Disability Puzzle for Adolescents With Persistent Pain.

Clin J Pain 2019 Feb;35(2):121-132

Royal Children's Hospital.

Objectives: Sensory modulation patterns contribute to altered pain perception and disengagement in activities; atypical sensory modulation patterns have been associated with higher pain sensitivity, catastrophizing, and reduced function. Objectives of this study were to ascertain whether: adolescents with persistent pain had atypical sensory modulation patterns, atypical sensory modulation was associated with reduced functioning and higher pain, and pain catastrophizing mediated the relationship between sensory modulation and functional disability.

Methods: Adolescents (N=70, females=63, males=7) attending tertiary level interdisciplinary team assessment for persistent pain completed sensory modulation (Adolescent/Adult Sensory Profile), pain catastrophizing (Bath Adolescent Pain Questionnaire), pain intensity, functional disability (Functional Disability Index), and quality of life (QOL) (Pediatric QOL Scales) questionnaires. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000663DOI Listing
February 2019
10 Reads

Effects of Spinal Cord and Peripheral Nerve Stimulation Reflected in Sensory Profiles and Endogenous Pain Modulation.

Clin J Pain 2019 Feb;35(2):111-120

Department of Neurology, Ruhr-University Bochum, BG-Kliniken Bergmannsheil, Bochum, Germany.

Objectives: Spinal cord and peripheral nerve stimulation (SCS/PNS) may alleviate chronic pain; however, the underlying mechanisms remain controversial. The aim of this observational study was to assess sensory changes in the ON-conditions and OFF-conditions to obtain insights into the mechanism of analgesic effects of SCS/PNS.

Materials And Methods: We contacted 85 patients and selected 28 patients with sufficient pain relief by SCS (n=15) or PNS (n=13) to assess their ongoing pain intensity (Numerical Rating Scale, 0 to 10), pain thresholds using Quantitative Sensory Testing (DFNS-protocol), and conditioned pain modulation (CPM) in a nonrandomized manner 2 to 4 hours after SCS/PNS deactivation (OFF-condition) and during stimulation (ON-condition). Read More

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http://dx.doi.org/10.1097/AJP.0000000000000661DOI Listing
February 2019
6 Reads

Evaluating Patient's Understanding of Pain Neurophysiology: Rasch Analysis of the Neurophysiology of Pain Questionnaire.

Clin J Pain 2019 Feb;35(2):133-139

College of Health & Biomedicine, Victoria University, Melbourne.

Objective: Educating patients about the neurobiologic basis of their pain experience is an important part of managing patients with pain disorders. The aim of this study was to evaluate the measurement properties of the Neurophysiology of Pain Questionnaire (NPQ) in a population seeking osteopathy treatment for both acute and chronic musculoskeletal pain symptoms.

Materials And Methods: Patients attending the Victoria University Osteopathy Clinic for their initial osteopathy consultation were recruited consecutively. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000658DOI Listing
February 2019
14 Reads

Contribution of Loss of Large Fiber Function to Pain in 2 Samples of Oncology Patients.

Clin J Pain 2019 Jan;35(1):37-42

School of Medicine.

Objectives: Numbness associated with neuropathic pain suggests the loss of function in myelinated, large diameter sensory neurons. The purpose of this study was to examine the relationships between pain severity and subjective (ie, severity of numbness) and objective (ie, loss of light touch sensations, vibration thresholds) measures of loss of large fiber function in adult survivors with chemotherapy-induced peripheral neuropathy (CIPN, n=426) and breast cancer patients with persistent postsurgical pain (n=80).

Material And Methods: For both samples, average pain and numbness were evaluated using a 0 to 10 numeric rating scale. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309865PMC
January 2019
2 Reads
2.530 Impact Factor

Evaluation of Digital Face Recognition Technology for Pain Assessment in Young Children.

Clin J Pain 2019 Jan;35(1):18-22

Pediatric Research in Emergency Therapeutics (PRETx.org) Department of Pediatrics, BC Children's Hospital, University of British Columbia, BC Children's Research Institute, Canada.

Objectives: Accurate assessment of pain in young children is challenging. An Emotion Application Programing Interface (API) can analyze and report 8 emotions from facial images. Each emotion ranges between 0 (no correlation) to 1 (greatest correlation). Read More

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http://dx.doi.org/10.1097/AJP.0000000000000659DOI Listing
January 2019
15 Reads

The Magnitude of Offset Analgesia as a Measure of Endogenous Pain Modulation in Healthy Participants and Patients With Chronic Pain: A Systematic Review and Meta-Analysis.

Clin J Pain 2019 Feb;35(2):189-204

Pain & Exercise Research Luebeck, University of Luebeck, Luebeck, Germany.

Objective: Offset analgesia (OA) is a test paradigm increasingly used to estimate endogenous pain modulation characterized by a disproportionally profound analgesia after a small decrease of a heat stimulus. This systematic review and meta-analysis examined the magnitude and difference of OA in healthy participants and chronic pain patients.

Materials And Methods: Controlled trials, case-control studies, cross-sectional studies, case-series or other observational studies evaluating the effect of a ±1°C offset trial in healthy controls and patients with chronic pain were searched in PubMed, Web of Science, CINAHL, PEDro, PsycINFO, and Cochrane CENTRAL. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000657DOI Listing
February 2019
1 Read

Pain-specific Reactions or Indicators of a General Stress Response?: Investigating the Discriminant Validity of 5 Well-established Neonatal Pain Assessment Tools.

Clin J Pain 2019 Feb;35(2):101-110

Department of Clinical Psychology, Justus-Liebig-University Giessen.

Objectives: There are many neonatal pain assessment tools available. However, systematic psychometric comparisons between tools are lacking, particularly those comparing tools regarding their ability to differentiate between pain and stressful procedures. The aim of the present study was to compare 5 widely used neonatal pain assessment tools: Neonatal Facial Coding System-Revised, Premature Infant Pain Profile-Revised, Neonatal Pain, Agitation and Sedation Scale, Neonatal Infant Pain Scale, and Bernese Pain Scale Neonates. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000660DOI Listing
February 2019
17 Reads

Influences of COMT rs4680 and OPRM1 rs1799971 Polymorphisms on Chronic Postsurgical Pain, Acute Pain, and Analgesic Consumption After Elective Cesarean Delivery.

Clin J Pain 2019 Jan;35(1):31-36

Department of Anesthesiology, Jiaxing Maternity and Children Health Care Hospital, Affiliated Women and Children Hospital, Jiaxing University, Zhejiang Province, China.

Objectives: The main objectives of this study were to assess the effects of cathechol-O-methyl-transferase (COMT) rs4680 and μ-opioid receptor rs1799971 polymorphisms alone or genotype combinations on chronic postsurgical pain (CPSP), acute pain, and analgesic consumption after elective cesarean delivery in a Chinese cohort.

Materials And Methods: Two hundred sixty-six patients undergoing elective cesarean delivery with a Pfannenstiel incision under spinal anesthesia were enrolled in this prospective, observational study. All patients were screened for rs4680 and rs1799971 using a peripheral venous blood sample of DNA. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000654DOI Listing
January 2019
2 Reads

Modification of Descending Analgesia in Aging: Critical Role of the Prefrontal Cortex.

Clin J Pain 2019 Jan;35(1):23-30

Laboratory of Cognitive Neuroscience and Adaptation, UMR 7364.

Objective: Aging has been associated with increases in pain threshold and reductions in tolerance threshold, as well as a deficiency in endogenous pain inhibition. Top-down pain modulation mainly involves the frontal cortex network, which is also one of the most vulnerable brain regions in aging. As the frontal cortex also sustains executive functions, we aimed to determine whether reductions in executive functions subtended by the frontal network are associated with the lack of descending inhibitor control in pain-free elderly participants. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000655DOI Listing
January 2019
14 Reads

Clinical Outcomes and Central Pain Mechanisms are Improved After Upper Trapezius Eccentric Training in Female Computer Users With Chronic Neck/Shoulder Pain.

Clin J Pain 2019 Jan;35(1):65-76

Department of Health Science and Technology, Center for Neuroplasticity and Pain (CNAP), SMI.

Objectives: The effects of eccentric exercises on clinical outcomes and central pain mechanisms are unclear in neck/shoulder pain (NSP). The aims were to: (1) evaluate the clinical impact of unilateral eccentric training in female computer users with chronic NSP; (2) compare pressure pain sensitivity, temporal summation of pain (TSP); and conditioned pain modulation (CPM) in female office workers with and without NSP; and (3) assess sensitization and central pain responses after training.

Methods: In part A, 20 females with NSP were compared with 20 controls. Read More

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January 2019
2 Reads

Staircase-evoked Pain May be More Sensitive Than Traditional Pain Assessments in Discriminating Analgesic Effects: A Randomized, Placebo-controlled Trial of Naproxen in Patients With Osteoarthritis of the Knee.

Clin J Pain 2019 Jan;35(1):50-55

Analgesic Solutions, Natick.

Objectives: Analgesic trials often fail to show a significant effect even when medications with known efficacy are tested. This could be attributed to insufficient assay sensitivity of analgesic trials, which may be due, in part, to the insensitivity of pain-related outcome measures. The aim of this methodological study was to assess the responsiveness of evoked pain generated by the staircase procedure compared with other commonly used pain outcomes in knee osteoarthritis. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000651DOI Listing
January 2019
1 Read

The Effects of Motor Imagery on Pain and Range of Motion in Musculoskeletal Disorders: A Systematic Review Using Meta-Analysis.

Clin J Pain 2019 Jan;35(1):87-99

Physiotherapy, Singapore General Hospital.

Introduction: In recent years, there has been an increase in the use of motor imagery (MI) in the rehabilitation of musculoskeletal pain conditions. Across the literature, most reviews have yet to consider Laterality Judgement Task training as a form of MI method. This review aimed to evaluate the effectiveness of using MI as an adjunct to standard rehabilitation on the improvement of pain and range of motion parameters when managing patients with musculoskeletal pain conditions. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000648DOI Listing
January 2019
6 Reads

Clinician Response to Aberrant Urine Drug Test Results of Patients Prescribed Opioid Therapy for Chronic Pain.

Clin J Pain 2019 Jan;35(1):1-6

Center to Improve Veteran Involvement in Care, VA Portland Health Care System.

Objective: Urine drug testing (UDT) is recommended for patients who are prescribed opioid medications, but little is known about the various strategies clinicians use to respond to aberrant UDT results. We sought to examine changes in opioid prescribing and implementation of other risk reduction activities following an aberrant UDT.

Methods: In a national cohort of Veterans Affairs patients with new initiations of opioid therapy through 2013, we identified a random sample of 100 patients who had aberrant positive UDTs (results positive for nonprescribed/illicit substance), 100 who had aberrant negative UDTs (results negative for prescribed opioid), and 100 who had expected UDT results. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283692PMC
January 2019
18 Reads

Evaluation of the Neuropathic Component of Chronic Low Back Pain.

Clin J Pain 2019 Jan;35(1):7-17

Department of Neurology, University Hospital and Masaryk University Brno.

Objectives: Assessment of neuropathic pain in chronic low back syndromes is important. However, there is currently no gold standard for its diagnosis. The aim of this observational cross-sectional study was to assess the neuropathic component of pain in various chronic low back pain syndromes using a range of diagnostic tests. Read More

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January 2019
3 Reads

Associations Between Musculoskeletal Pain Experience and Pressure and Cold Pain Sensitivity: A Community-based Cross-sectional Study of Young Adults in the Raine Study.

Clin J Pain 2019 Jan;35(1):56-64

School of Physiotherapy and Exercise Science, Curtin University, Perth, WA.

Objectives: To investigate the cross-sectional associations between musculoskeletal pain experience and measures of pressure and cold pain sensitivity in young adults from the Western Australian Pregnancy Cohort (Raine) Study.

Participants And Methods: In total, 917 participants were eligible for analysis if they provided data pertaining to musculoskeletal pain status at the 22-year follow-up and had data for at least 1 valid pain sensitivity test. Standardized protocols were used to assess pressure pain threshold (4 sites: lumbar spine, tibialis anterior, upper trapezius, and wrist) and cold pain threshold (wrist). Read More

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January 2019
10 Reads

Predicting Procedure-specific Morphine Consumption of Intravenous Patient-controlled Analgesia With Random-effect Model Approach.

Clin J Pain 2019 Jan;35(1):43-49

Department of Anesthesiology, Taipei Veterans General Hospital and School of Medicine, National Yang-Ming University.

Introduction: Surgical procedure is an important predictor for analgesic consumptions of intravenous patient-controlled analgesia (IV-PCA) for acute pain.

Objectives: The aim of this study was to better fit the analgesic consumptions of IV-PCA with regard to the different surgical procedures.

Materials And Methods: A statistical model (random-effect model) was proposed to develop procedure-specific morphine consumptions for various surgical procedures of IV-PCA. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000647DOI Listing
January 2019
1 Read

Effect of Intravenous Oxycodone in Combination With Different Doses of Dexmedetomdine on Sleep Quality and Visceral Pain in Patients After Abdominal Surgery: A Randomized Study.

Clin J Pain 2018 Dec;34(12):1126-1132

Departments of Anesthesia.

Objective: Oxycodone or dexmedetomidine (DEX) alone are widely used in clinical practice. The aim of this study was to observe the effect of 2 oxycodone and DEX combinations on postoperative sleep quality.

Methods: This was a prospective and randomized clinical study. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000645DOI Listing
December 2018
5 Reads
2.527 Impact Factor

Assessment of Pain-related Disability in Pediatric Chronic Pain: A Comparison of the Functional Disability Inventory and the Pediatric Pain Disability Index.

Clin J Pain 2018 Dec;34(12):1173-1179

German Paediatric Pain Centre, Children's and Adolescents' Hospital Datteln, Department of Children's Pain Therapy and Paediatric Palliative Care, Witten/Herdecke University, Faculty of Health, School of Medicine, Witten, Germany.

Objectives: The assessment of pain-related disability in pediatric chronic pain patients plays an important role in research on the effectiveness of pain treatment. The present study aimed to compare the 2 available measures of pain-related disability in the German language, the Functional Disability Inventory (FDI) and Pediatric Pain Disability Index (PPDI), in terms of psychometric properties and convergent validity. In addition, associations between FDI/PPDI scores and sex, age, and pain locations were investigated. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000646DOI Listing
December 2018
17 Reads

Clinical Pain-related Outcomes and Inflammatory Cytokine Response to Pain Following Insomnia Improvement in Adults With Knee Osteoarthritis.

Clin J Pain 2018 Dec;34(12):1133-1140

University of Rochester Medical Center, Rochester.

Objectives: Clinical insomnia is known to affect pain, but mechanisms are unclear. Insomnia can dysregulate inflammatory pathway, and inflammation plays a mediating role in pain. It is unclear whether insomnia-related alterations in inflammation can be modified with insomnia improvement, and if such alterations parallel improvement in pain. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219931PMC
December 2018
2 Reads

Opioid-related Emergency Department Visits and Hospitalizations Among Commercially Insured Individuals, 2009-2015.

Clin J Pain 2018 Dec;34(12):1121-1125

Zablocki VA Medical Center.

Objectives: Overall opioid prescribing rates have decreased since 2012, but opioid-involved deaths have not. This study describes the regional and overall trends of opioid-related emergency department visits (EDVs) and hospitalizations of commercially insured patients on chronic opioids and those on concurrent opioids and benzodiazepines.

Methods: Secondary data analysis from Truven Health MarketScan Commercial Claims and Encounters (MarketScan) database from 2009 to 2015 was used. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000643DOI Listing
December 2018
1 Read

Optimism and Psychological Resilience are Beneficially Associated With Measures of Clinical and Experimental Pain in Adults With or at Risk for Knee Osteoarthritis.

Clin J Pain 2018 Dec;34(12):1164-1172

Pain Research and Intervention Center of Excellence (PRICE).

Objectives: This cross-sectional study examined the associations among optimism, psychological resilience, endogenous pain inhibition, and clinical knee pain severity. Two hypotheses were tested. First, we hypothesized that experimentally tested endogenous pain inhibition would mediate the relationship between optimism and clinical knee pain severity. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219932PMC
December 2018
5 Reads

Do Physicians Underestimate Pain in Terminal Cancer Patients? A Prospective Study in a Hospice Setting.

Clin J Pain 2018 Dec;34(12):1159-1163

Family Medicine Practice, Rijeka, Croatia.

Objectives: Unrelieved pain is present in a majority of terminal cancer patients. However, the treatment of pain in palliative and hospice care is affected by the lack of validated pain assessment. The goal of this study was to evaluate differences in pain evaluation between terminal cancer patients and physicians and evaluate the pain levels as a survival biomarker. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000641DOI Listing
December 2018
19 Reads

Risk and Resilience in Pediatric Pain: The Roles of Parent and Adolescent Catastrophizing and Acceptance.

Clin J Pain 2018 Dec;34(12):1096-1105

Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford/Lucile Packard Pediatric Pain Management Clinic, Menlo Park, CA.

Objectives: Both pediatric and parent pain catastrophizing and pain acceptance are key factors associated with pediatric pain outcomes; however, the interactive effects of these factors within the parent-child dyad have yet to be tested. The aims of this study were to examine: (1) the mediating role of child catastrophizing between parent catastrophizing and child outcomes (pain interference and mobility), (2) the mediating role of child acceptance between parent acceptance and child outcomes, and (3) whether child acceptance buffers the relation between parent catastrophizing and child catastrophizing, which in turn impacts child outcomes.

Materials And Methods: Cross-sectional data from 324 youth with chronic pain ages 10 to 17 years (mean age=14. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219922PMC
December 2018
1 Read

Effects of the OPRM1 A118G Polymorphism (rs1799971) on Opioid Analgesia in Cancer Pain: A Systematic Review and Meta-Analysis.

Clin J Pain 2019 Jan;35(1):77-86

Department of Clinical Oncology, Xijing Hospital, the Fourth Military Medical University, Xi'an, China.

Objectives: Although previous studies have demonstrated that the OPRM1 A118G polymorphism may influence the analgesia response to cancer pain, the results are inconsistent. In this article we aimed to fully examine the association between OPRM1 A118G (rs1799971) polymorphism and opioid analgesia by analyzing published information. This will provide information for better cancer pain management. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000636DOI Listing
January 2019
7 Reads