2,792 results match your criteria The Clinical journal of pain[Journal]


Associations between Physical Activity and Chronic Pain Severity in Youth With Chronic Abdominal Pain.

Clin J Pain 2019 Apr 18. Epub 2019 Apr 18.

Children's Mercy Hospital.

Objectives: The present study aimed to: (1) better understand physical activity levels in youth with chronic abdominal pain and (2) investigate the relationship between day-level physical activity related to next day pain intensity to identify any intra-individual heterogeneity.

Methods: Seventy-one youth (M=13.34▒y, SD=2. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000716DOI Listing

Complications of Postoperative Epidural Analgesia for Oncologic Surgery: A Review of 18,895 Cases.

Clin J Pain 2019 Apr 18. Epub 2019 Apr 18.

The Department of Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.

Objectives: The risks of epidural analgesia differ depending on the population studied. We describe our experience with postoperative epidural analgesia for oncologic surgery.

Materials And Methods: After approval from the Institutional Review Board of The University of Texas MD Anderson Cancer Center to conduct this retrospective analysis, we searched our acute pain medicine database for cases in which postoperative epidural analgesia was used between 2003 and 2012. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000718DOI Listing

A Systemic Approach to Complete the Multimodal Assessment Model of Pain.

Clin J Pain 2019 Apr 15. Epub 2019 Apr 15.

Lyon Public Hospices, France, Systemic Health Pathway Laboratory, Lyon, France.

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http://dx.doi.org/10.1097/AJP.0000000000000715DOI Listing

Empirical Grouping of Pain Zones in Fibromyalgia. A Preliminary Study.

Clin J Pain 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Psychology, National Distance Education University (UNED), Madrid, Spain.

Objectives: Widespread pain is important for the diagnosis of fibromyalgia (FM). For this purpose, the sum of pain regions obtained from a topographical distribution has been used to compute a widespread pain index (WPI), but there is no empirical basis for choosing the regions. The aim of this study was to find an empirical distribution of the pain regions. Read More

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http://Insights.ovid.com/crossref?an=00002508-900000000-9883
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http://dx.doi.org/10.1097/AJP.0000000000000717DOI Listing
April 2019
2 Reads

The Use of Opioids for Treatment of Pediatric Neuropathic Pain: A Literature Review.

Clin J Pain 2019 Apr 12. Epub 2019 Apr 12.

Department of Anesthesiology and Pain Medicine, Seattle Children's Hospital, Seattle, WA, USA.

Pediatric neuropathic pain is caused by a spectrum of disorders that are generally challenging to treat. Many of the underlying altered neurologic processes are being elucidated through mechanistic studies. Few randomized control trials have evaluated the use of opioids for the treatment of adult neuropathic pain conditions, and there have been none in pediatric populations. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000712DOI Listing
April 2019
3 Reads

Opioid Use Disorder in Children and Adolescents: Risk Factors, Detection, and Treatment.

Clin J Pain 2019 Apr 12. Epub 2019 Apr 12.

Anesthesiology and Pediatrics, University of Colorado, Children's Hospital Colorado, Aurora, CO.

Opioid medications are an important tool in the management of pain and have been used in clinical practice for centuries. However, due to the highly addictive nature of this class of medications coupled with the life-threatening side effect of respiratory depression, opioid misuse has become a significant public health crisis worldwide. Children and adolescents are at risk for opioid misuse, and early detection is imperative to facilitate treatment and improve outcomes. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000708DOI Listing
April 2019
1 Read

Opioid Pharmacology: Developmental Effects on Opioid Metabolism.

Authors:
Ernest A Kopecky

Clin J Pain 2019 Apr 12. Epub 2019 Apr 12.

Aims/objectives/background: Children represent a patient demographic composed of multiple, unique subpopulations differentiated by rapidly changing age-related physiology, which includes the means of metabolizing opioids. Opioids are an important part of the pharmacological treatment of both acute and chronic pain. In both clinical medicine and clinical research, it is necessary to understand the differences in drug handling by age cohort in order to appropriately dose children to effect, and to avoid exacerbating deleterious adverse events with potentially grave sequelae. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000710DOI Listing
April 2019
1 Read

From Tramadol to Methadone: Opioids in the Treatment of Pain and Dyspnea in Pediatric Palliative Care.

Clin J Pain 2019 Apr 12. Epub 2019 Apr 12.

Children's Hospitals and Clinics of Minnesota.

Background: More than 15,000 children die annually in the United States due to an underlying life-limiting disease and the majority of those children experience distressing symptoms, which are not adequately relieved, such as pain and dyspnea. Multimodal analgesia, that is multiple agents, interventions, rehabilitation, psychological modalities, and integrative (nonpharmacologic) therapies, act synergistically for more effective pediatric pain and symptom control with fewer side effects than a single analgesic or modality. However, opioids, such as morphine, fentanyl, hydromorphone, oxycodone, and methadone (in the United Kingdom: diamorphine) remain the mainstay medication to effectively treat pain and dyspnea in children with serious illness. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000704DOI Listing

Molecular Biology of Opioid Analgesia and Its Clinical Considerations.

Clin J Pain 2019 Apr 12. Epub 2019 Apr 12.

Department of Anesthesiology, Pain and Perioperative Medicine, Children's National Health System, Washington, DC.

Understanding the molecular biology of opioid analgesia is essential for its proper implementation and mechanistic approach to its modulation in order to maximize analgesia and minimize undesired effects. By appreciating the molecular mechanisms intrinsic to opioid analgesia, one can manipulate a molecular target to augment or diminish a specific effect using adjuvant drugs, select an appropriate opioid for opioid rotation or define a molecular target for new opioid drug development. In this review, we present the cellular and molecular mechanisms of opioid analgesia and that of the associated phenomena of tolerance, dependence, and hyperalgesia. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000705DOI Listing

Opioids in the Management of Acute Pediatric Pain: An Update in a Time of Crisis.

Clin J Pain 2019 Apr 12. Epub 2019 Apr 12.

Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD.

Management of acute pain in children is fundamental to our practice. Its myriad benefits include reduced suffering, improved patient satisfaction, more rapid recovery, and a reduced risk of developing postsurgical chronic pain. Although a multimodal analgesic approach is now routinely used, informed and judicious use of opioid receptor agonists remains crucial in this treatment paradigm, as long as the benefits and risks are fully understood. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000709DOI Listing
April 2019
1 Read

Opioid-prescribing Patterns for Pediatric Patients in the United States.

Clin J Pain 2019 Apr 12. Epub 2019 Apr 12.

Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA.

Background And Objectives: The opioid crisis in America affects both adults and children. However, knowledge about the epidemiology of the opioid crisis, opioid prescribing patterns, and the link between opioid prescribing and problematic opioid behaviors remain limited. Thus, children are often excluded from health care policies and guidelines aimed at curbing the opioid crises. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000707DOI Listing
April 2019
3 Reads

The Role of Neuraxial Opioids in Pediatric Practice.

Clin J Pain 2019 Apr 12. Epub 2019 Apr 12.

Department of Anesthesiology, Clinical Pediatrics and Anesthesia, Pain Management Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Neuraxial-spinal and epidural-administration of opioids can be an effective method for controlling pain for children in a number of clinical settings. Understanding the basic pharmacologic and logistical concepts will make it easier for pediatricians to advocate for their patients, and support patients and families when circumstances suggest that neuraxial opioid treatment is appropriate. This review article summarizes the basic concepts of pharmacology, drug choice, side effects, and complications as well as situations in which neuraxial opioids are appropriate in children. Read More

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http://Insights.ovid.com/crossref?an=00002508-900000000-9883
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http://dx.doi.org/10.1097/AJP.0000000000000706DOI Listing
April 2019
1 Read

The Opioid Wars-CON: The Risks of Opioids for Pain Management Outweigh the Benefits.

Clin J Pain 2019 Apr 12. Epub 2019 Apr 12.

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Lucile Packard Children's Hospital Stanford, Stanford, CA.

The entire field of medicine, not just anesthesiology, has grown comfortable with the risks posed by opioids; but these risks are unacceptably high. It is time for a dramatic paradigm shift. If used at all for acute or chronic pain management, they should be used only after consideration and maximizing the use of nonopioid pharmacologic agents, regional analgesia techniques, and nonpharmacologic methods. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000702DOI Listing
April 2019
1 Read

The Opioid Debate-PRO: Opioids Have an Important Role in Pain Management in Children.

Authors:
Elliot J Krane

Clin J Pain 2019 Apr 12. Epub 2019 Apr 12.

Departments of Anesthesiology, Perioperative & Pain Medicine and Pediatrics, Stanford University, Stanford, CA.

The increase in opioid-related deaths in the United States (and other countries) has prompted a national debate in medicine about the appropriateness of opioids for the treatment of acute and chronic pain, and specifically in children, if medical opioid use causes or increases the risk of opioid use disorder (OUD) later in life. Some in the medical community and in government advocate withholding opioids from children after an arbitrary number of days of treatment, regardless of diagnosis. Here, I argue that opioid experimentation and misuse is no more common in children and adolescents today than 2 or 3 decades ago, that there is no compelling evidence that appropriate medical use of opioids leads to OUD, and that the epidemic of inadequately treated pain in children remains the more compelling issue. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000700DOI Listing

With Apologies to Lennon and McCartney, All We Need is Data: Opioid Concerns in Pediatrics.

Clin J Pain 2019 Apr 12. Epub 2019 Apr 12.

Departments of Anesthesiology and Psychiatry, University of Washington, Seattle, WA.

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http://dx.doi.org/10.1097/AJP.0000000000000699DOI Listing
April 2019
1 Read

Socially Assistive Robots for Helping Pediatric Distress and Pain: A Review of Current Evidence and Recommendations for Future Research and Practice.

Clin J Pain 2019 May;35(5):451-458

University of Southern California, Viterbi School of Engineering, Los Angeles, CA.

Objectives: Interacting with socially assistive robots (SAR) has been shown to influence human behaviors and emotions. This study sought to review the literature on SAR intervention for reducing pediatric distress and pain in medical settings.

Methods: Databases (PubMed, Cochrane Library, CINAHL, PsycINFO, ERIC, Web of Science, Engineering Village, Scopus, Google Scholar, IEEE Xplore) were searched from database inception to January 2018 with the aid of a medical librarian. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000688DOI Listing
May 2019
1 Read

Presurgical Comorbidities as Risk Factors for Chronic Postsurgical Pain Following Total Knee Replacement.

Clin J Pain 2019 Apr 3. Epub 2019 Apr 3.

Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark.

Objectives: Chronic postsurgical knee-pain (CPSP) is a burden for approx. 20% of the patients following total knee replacement (TKR). Presurgical pain intensities have consistently been found associated with CPSP and it is suggested that e. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000714DOI Listing
April 2019
3 Reads

The Mediating Effect of Pain Catastrophizing on PTSD Symptoms and Pain Outcome.

Clin J Pain 2019 Apr 3. Epub 2019 Apr 3.

Mayo Clinic, Rochester, MN: 200 First Street SW, Rochester, MN 55905, USA.

Objective: Co-prevalence of chronic pain and post-traumatic stress disorder (PTSD) negatively impacts the course of both disorders. Patients diagnosed with both conditions report greater pain, affective distress and disability when compared to those with either chronic pain or PTSD alone. While the prevalence and complexity of the comorbidity is widely acknowledged, there is a dearth of research examining potential mechanism variables that might account for the relationship between chronic pain and PTSD. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000713DOI Listing
April 2019
4 Reads

Associations Between Sleep Disturbance and Chronic Pain Intensity and Function: A Test of Direct and Indirect Pathways.

Clin J Pain 2019 Mar 25. Epub 2019 Mar 25.

Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA.

Objectives: Sleep disturbance and chronic pain are related. The present study evaluated both direct and indirect (mediated) pathways through which sleep disturbance might be related to chronic pain intensity and function.

Methods: Eighty-seven individuals (64% female) with chronic low back pain but not using opioids daily completed questionnaires assessing their sleep disturbance, chronic pain intensity, function, depression, anxiety, positive affect, and catastrophizing. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000711DOI Listing
March 2019
3 Reads

The Effect of Patient Characteristics on Acupuncture Treatment Outcomes: An Individual Patient Data Meta-Analysis of 20,827 Chronic Pain Patients in Randomized Controlled Trials.

Clin J Pain 2019 May;35(5):428-434

Memorial Sloan Kettering Cancer Center, New York, NY.

Objectives: To optimally select chronic pain patients for different treatments, as it is of interest to identify patient characteristics that might moderate treatment effect. Our aim was to evaluate the impact of possible moderators on the effect of acupuncture treatment using a large data set.

Methods: We used data from an individual patient data meta-analysis of high-quality randomized trials of acupuncture for chronic headache and migraine, osteoarthritis, and back, neck, and shoulder pain. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450709PMC
May 2019
2 Reads

Transversus Thoracic Muscle Plane Block for Breast Surgery.

Clin J Pain 2019 May;35(5):459-460

Department of Surgery, Anesthesia and Intensive Care Section "G.B. Morgagni-Pierantoni" Hospital Forlì, Italy.

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http://dx.doi.org/10.1097/AJP.0000000000000694DOI Listing

Support for My Video is Support for Me: A YouTube Scoping Review of Videos Including Adolescents With Chronic Pain.

Clin J Pain 2019 May;35(5):443-450

Division of Psychology, Faculty of Natural Sciences, University of Stirling, Stirling, Scotland, UK.

Objectives: Adolescents are heavy users of social media as a venue to share experience and obtain information. Adolescents with chronic pain may be no different. Given that adolescents with chronic pain report feelings of social isolation, of being different, and lack peer understanding, social media may help them obtain social support. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000693DOI Listing

(Non) Pharmacological Modalities in Acute Procedural Pain.

Clin J Pain 2019 May;35(5):459

Department of Anesthesiology and Peri-operative Medicine, University Hospital of Brussels (UZBrussel), Free University of Brussels (VUB), Brussels, Belgium.

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http://dx.doi.org/10.1097/AJP.0000000000000687DOI Listing

Youth With Chronic Pain and a History of Adverse Childhood Experiences in the Context of Multidisciplinary Pain Rehabilitation.

Clin J Pain 2019 May;35(5):420-427

Department of Anesthesiology, Pain, and Perioperative Medicine, Division of Pain Medicine, Boston Children's Hospital.

Objectives: Previous research has shown that youth with chronic pain who presented for a multidisciplinary evaluation report a history of adverse childhood experiences (ACEs) (eg, abuse, neglect, parent/guardian separation or divorce) at a high rate (over 80%) and that those with pain and ACEs experience increased psychosocial impairment. Outside of chronic pain, evidence also suggests that youth with a history of ACEs experience poorer treatment outcomes. However, no study to date has examined treatment outcomes in youth with chronic pain and a history of ACEs. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000686DOI Listing

The Impact of Female Chronic Pelvic Pain Questionnaire (IF-CPPQ): A Validation Study.

Clin J Pain 2019 Mar 8. Epub 2019 Mar 8.

Department of Psychology, University of Southampton, University Road, Southampton, SO17 1BJ.

Objectives: The aim of this study was to assess the validity, reliability, and factor structure of the Impact of Female Chronic Pelvic Pain Questionnaire (IF-CPPQ).

Methods: This was a cross-sectional questionnaire study that was administered online. To be eligible to participate, women had to have experienced chronic pelvic pain (CPP) for a minimum of three months and be at least 18 years of age. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000703DOI Listing
March 2019
1 Read

School Absence Associated with Childhood Pain in the United States.

Clin J Pain 2019 Mar 5. Epub 2019 Mar 5.

Departments of Anesthesiology and Pain Medicine.

Objective: To estimate the national burden of school absenteeism associated with pain among 6-17 year old children in the United States.

Methods: Data were analyzed from a large, nationally representative sample from the 2012 National Health Interview Survey. Associations between pain and school absence were analyzed using multivariate negative binomial models controlling for sociodemographic and clinical characteristics. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000701DOI Listing
March 2019
5 Reads

Sleep and Pain: A Systematic Review of Studies of Mediation.

Clin J Pain 2019 Feb 28. Epub 2019 Feb 28.

Department of Psychology, University of Warwick, Coventry, UK.

Objectives: A relationship between sleep and pain is well established. A better understanding of the mechanisms that link sleep and pain intensity is urgently needed to optimise pain management interventions. The objective of this systematic review was to identify, synthesise and critically appraise studies that have investigated putative mediators on the path between sleep and pain intensity. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000697DOI Listing
February 2019
2 Reads

Musculoskeletal Pain in Individuals with Inflammatory Bowel Disease Reflects Three Distinct Profiles.

Clin J Pain 2019 Feb 28. Epub 2019 Feb 28.

University of Otago - School of Physiotherapy.

Objectives: Pain affects over 70% of individuals with inflammatory bowel disease (IBD), with abdominal and musculoskeletal pain representing the most common complaints. Musculoskeletal pain in IBD is reported to be associated with multiple clinical features, however the scope and nature of pain is not well understood. Primary aims were to identify subgroups of musculoskeletal pain in individuals with IBD based on clinical features of pain, and assess how these subgroups differ in aspects of demographics, comorbidity, and IBD characteristics. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000698DOI Listing
February 2019
5 Reads

Efficacy of the Buzzy Device for Pain Management during Needle-Related Procedures: A Systematic Review and Meta-analysis.

Clin J Pain 2019 Feb 28. Epub 2019 Feb 28.

Faculty of Nursing, University of Montreal, Montreal, Quebec, Canada.

Objective: This systematic review and meta-analysis examined the effectiveness of the Buzzy device combining cold and vibration for needle-related procedural pain in children.

Methods: Databases search was conducted from inception to December 2017 to identify randomized controlled trials using the Buzzy device for pain management in children undergoing needle-related procedures. Selection of studies, data extraction, and assessment of risk of bias and quality of evidence were independently performed by two reviewers. Read More

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http://Insights.ovid.com/crossref?an=00002508-900000000-9885
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http://dx.doi.org/10.1097/AJP.0000000000000690DOI Listing
February 2019
7 Reads

Effect of Preperitoneal Versus Epidural Analgesia on Postoperative Inflammatory Response and Pain Following Radical Cystectomy: A Prospective, Randomized Trial.

Clin J Pain 2019 Apr;35(4):328-334

Surgical Oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

Objectives: Continuous wound infiltration of local anesthetics has been proposed as an alternative to epidural analgesia during abdominal surgery. Cytokines have a major role in inflammatory changes caused by surgery. This study aimed to compare the effects of continuous preperitoneal versus epidural analgesia on inflammatory cytokines postoperatively. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000679DOI Listing
April 2019
3 Reads

Precollision Medical Diagnoses Predict Chronic Neck Pain Following Acute Whiplash Trauma.

Clin J Pain 2019 Apr;35(4):304-314

The Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital.

Objectives: The reason why some individuals develop chronic symptoms, whiplash-associated disorder, following whiplash trauma is poorly understood. We explored whether precollision pain-related diagnoses, medically unexplained symptoms, and psychiatric diagnoses are related to whiplash-associated disorder.

Materials And Methods: A cohort of 719 individuals exposed to whiplash trauma and subsequently experiencing symptoms within 72 hours (whiplash-exposed cohort) and 3595 matched controls were included in this observational prospective study. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000683DOI Listing

The Association Between Conditioned Pain Modulation and Manipulation-induced Analgesia in People With Lateral Epicondylalgia.

Clin J Pain 2019 May;35(5):435-442

School of Physiotherapy and Exercise Science, Curtin University.

Objectives: Conditioned pain modulation (CPM) and manipulation-induced analgesia (MIA) may activate similar neurophysiological mechanisms to mediate their analgesic effects. This study assessed the association between CPM and MIA responses in people with lateral epicondylalgia.

Materials And Methods: Seventy participants with lateral epicondylalgia were assessed for CPM followed by MIA. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000696DOI Listing
May 2019
1 Read

Exposure to Cold Unmasks Potential Biomarkers of Fibromyalgia Syndrome Reflecting Insufficient Sympathetic Responses to Stress.

Clin J Pain 2019 May;35(5):407-419

Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, MN.

Objectives: Fibromyalgia syndrome (FMS) is a chronically painful condition whose symptoms are widely reported to be exacerbated by stress. We hypothesized that female patients with FMS differ from pain-free female controls in their sympathetic responses, a fact that may unmask important biomarkers and factors that contribute to the etiology of FMS.

Materials And Methods: In a pilot study, blood pressure (BP), skin temperature, thermogenic activity, circulating glucose, and pain sensitivity of 13 individuals with FMS and 11 controls at room temperature (24°C) were compared with that after exposure to cold (19°C). Read More

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http://dx.doi.org/10.1097/AJP.0000000000000695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450706PMC
May 2019
3 Reads

Analgesic Potentials of Preoperative Oral Pregabalin, Intravenous Magnesium Sulfate, and their Combination in Acute Postthoracotomy Pain.

Clin J Pain 2019 Mar;35(3):247-251

Department of Anesthesiology and Pain Relief, National Cancer Institute, Cairo University, Cairo.

Objectives: The objective of this study was to investigate the effects of the preoperative combination of oral Pregabalin and intravenous (IV) magnesium sulfate as analgesic adjuvants in postthoracotomy pain.

Patients And Methods: One hundred twenty patients with American Society of Anesthesiologists physical status II were allocated randomly into 1 of 4 groups. Group MP received 300 mg pregabalin orally and an IV infusion of magnesium sulfate 50 mg/kg mixed with 200 mL normal saline (NS); group P received 300 mg pregabalin orally and 200 mL NS infusion; group M received an IV infusion of magnesium sulfate 50 mg/kg mixed with 200 mL NS and a placebo capsule; and group C received placebo capsule and an IV infusion of 200 mL NS. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000673DOI Listing
March 2019
2 Reads

Posttraumatic Stress Symptoms Mediate the Effects of Trauma Exposure on Clinical Indicators of Central Sensitization in Patients With Chronic Pain.

Clin J Pain 2019 May;35(5):385-393

Department of Psychology, The Ohio State University, Columbus, OH.

Objective: Evidence supports high rates of co-occurrence of posttraumatic stress disorder (PTSD) and chronic pain disorders involving central sensitization (CS). The nature of this relationship, however, remains relatively unexplored. In this study, we aimed to (1) assess how both trauma exposure and current PTSD symptoms are related to clinical manifestations of CS, and (2) test whether PTSD symptoms explain the relationship between trauma exposure and CS. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450707PMC
May 2019
1 Read

Changes in the Organization of the Secondary Somatosensory Cortex While Processing Lumbar Proprioception and the Relationship With Sensorimotor Control in Low Back Pain.

Clin J Pain 2019 May;35(5):394-406

KU Leuven Department of Rehabilitation Sciences, Leuven.

Objectives: Patients with nonspecific low back pain (NSLBP) rely more on the ankle compared with the lower back proprioception while standing, perform sit-to-stand-to-sit (STSTS) movements slower, and exhibit perceptual impairments at the lower back. However, no studies investigated whether these sensorimotor impairments relate to a reorganization of the primary and secondary somatosensory cortices (S1 and S2) and primary motor cortex (M1) during proprioceptive processing.

Materials And Methods: Proprioceptive stimuli were applied at the lower back and ankle muscles during functional magnetic resonance imaging in 15 patients with NSLBP and 13 controls. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000692DOI Listing

Pain Catastrophizing and Function In Individuals With Chronic Musculoskeletal Pain: A Systematic Review and Meta-Analysis.

Clin J Pain 2019 Mar;35(3):279-293

Department of Physiotherapy.

Objectives: Pain catastrophizing (PC) is the most consistent psychosocial factor predicting of adjustment to chronic pain and may contribute to the development and long-term maintenance of chronic pain. The aim of this review was systematically review and critically appraise the concurrent and longitudinal associations between PC and both pain intensity and disability in individuals with chronic musculoskeletal pain (CMP).

Materials And Methods: An electronic search of PubMed, Scopus, AMED, CINAHL, PsycINFO, and PubPsych databases, as well as gray literature, was undertaken from inception until September 2018. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000676DOI Listing
March 2019
1 Read

Telehealth Therapy Effects of Nurses and Mental Health Professionals From 2 Randomized Controlled Trials for Chronic Back Pain.

Clin J Pain 2019 Apr;35(4):295-303

VA San Diego Healthcare System.

Objective: To compare the efficacy of mental health professional versus primary care nurse-delivered telehealth cognitive-behavioral therapy (CBT) and supportive care (SC) treatments for chronic low back pain, using data from 2 separate randomized controlled trials. Both trials were completed in the same hospital and used the same study design, research team, and outcome measures.

Materials And Methods: Participants from Study 1 (Mental Health Professional Study) (N=66; 2007 to 2011) and Study 2 (Nursing Study) (N=61; 2012 to 2016) were patients with chronic low back pain (≥4/10 intensity) randomized to either an 8-week CBT or an SC telehealth condition matched for contact frequency, format, and time. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000678DOI Listing
April 2019
13 Reads

TRPA1 Sensitization Produces Hyperalgesia to Heat but not to Cold Stimuli in Human Volunteers.

Clin J Pain 2019 Apr;35(4):321-327

Institute of Clinical Pharmacology, Goethe-University.

Background: Transient receptor potential ion channels play a role in thermal hyperalgesia and are among targets of novel analgesics. However, a role of TRPA1 in either heat or cold hyperalgesia is controversial. In this study, changes in thermal sensitivity were assessed following topical application of a specific sensitizer of TRPA1 and compared with the effects of sensitizers of TRPV1 and TRPM8. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000677DOI Listing
April 2019
14 Reads

Variables Associated With the Use of Prophylactic Amitriptyline Treatment in Patients With Tension-type Headache.

Clin J Pain 2019 Apr;35(4):315-320

Department Physical Therapy, Occupational Therapy, Rehabilitation, and Physical Medicine, University Rey Juan Carlos.

Objective: The objective of this study was to investigate differences in clinical, psychological, and psychophysical outcomes according to use of prophylactic medication (amitriptyline) in tension-type headache (TTH).

Methods: In total, 173 individuals with TTH participated. Headache features and symptomatic medication intake were collected with a 4-weeks headache diary at baseline and at 6-months. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000685DOI Listing
April 2019
7 Reads

Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated With Widespread Pressure Pain Sensitivity and Depression in Women With Chronic, but not Episodic, Tension-Type Headache.

Clin J Pain 2019 Apr;35(4):345-352

Department of Health Science and Technology, School of Medicine, Center for Sensory-Motor Interaction (SMI), Aalborg University, Aalborg, Denmark.

Objectives: The aims of this study were: (1) to investigate the association between the rs4680 Val158Met polymorphism in frequent episodic tension-type headache (FETTH) and chronic tension-type headache (CTTH); and (2) to analyze the association between the rs4680 Val158Met polymorphism with clinical, psychological, or psychophysical variables.

Methods: In total, 50 women with FETTH, 50 with CTTH, and 50 matched headache-free women participated. After amplifying Val158Met polymorphism by polymerase chain reaction, the genotype frequencies and allele distributions based on restriction fragment length polymorphism were assessed. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000684DOI Listing
April 2019
5 Reads

Multidisciplinary Treatment for Provoked Vestibulodynia: Treatment Trajectories, Predictors, and Moderators of Sexual Distress and Pain.

Clin J Pain 2019 Apr;35(4):335-344

Department of Obstetrics & Gynaecology, University of British Columbia.

Objectives: Multidisciplinary treatment programs for provoked vestibulodynia (PVD) are recommended, yet few have been evaluated. This study examined women's symptom trajectories over time, as well as baseline demographic, psychosocial and pain characteristics as predictors/ moderators of sexual pain and distress following treatment at a clinic using multidisciplinary concurrent methods. We also examined the impact of baseline variables on the probability of having low sexual distress scores following treatment. Read More

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http://Insights.ovid.com/crossref?an=00002508-900000000-9886
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http://dx.doi.org/10.1097/AJP.0000000000000682DOI Listing
April 2019
21 Reads

Effect of Local Anesthetic Versus Botulinum Toxin-A Injections for Myofascial Pain Disorders: A Systematic Review and Meta-Analysis.

Clin J Pain 2019 Apr;35(4):353-367

Department of Medicine, Division of Physical Medicine and Rehabilitation, University of Toronto, Toronto.

Objective: Myofascial pain is a chronic pain disorder characterized by the presence of painful localized regions of stiff muscle and/or myofascial trigger points. Intramuscular myofascial trigger point injections are considered first-line treatments for myofascial pain. Common injectates include local anesthetics and botulinum toxin-A (BTX-A). Read More

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http://dx.doi.org/10.1097/AJP.0000000000000681DOI Listing
April 2019
12 Reads
2.527 Impact Factor

Pre-collision Medical Diagnoses Predict Chronic Neck Pain Following Acute Whiplash-trauma.

Clin J Pain 2018 Dec 26. Epub 2018 Dec 26.

The Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus C, Denmark.

Objectives: The reason why some individuals develop chronic symptoms, whiplash-associated disorder, following whiplash trauma is poorly understood. We explored whether pre-collision pain-related diagnoses, medically unexplained symptoms and psychiatric diagnoses are related to whiplash-associated disorder.

Methods: A cohort of 719 individuals exposed to whiplash trauma and subsequently experiencing symptoms within 72 hours (whiplash-exposed cohort) and 3595 matched controls were included in this observational prospective study. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000683DOI Listing
December 2018
8 Reads
2.527 Impact Factor

Exploring the Role of Regional Anesthesia in the Treatment of the Burn-injured Patient: A Narrative Review of Current Literature.

Clin J Pain 2019 Apr;35(4):368-374

School of Nursing, Midwifery and Social Work, The University of Queensland, St Lucia, Qld, Australia.

Objectives: The review article was designed to assess the effectiveness of regional anesthesia (RA), specifically peripheral nerve blocks, in the treatment of burn pain; with noting of clinical indications and contraindications for peripheral nerve block application, along with discussion of evidence-based analgesic strategies for providing improved, comprehensive burn pain management.

Materials And Methods: A search of relevant literature was performed using CINAHL, PubMed, EMBASE, Web of Science, and SCOPUS with a publication date between January 2005 and December 2017.

Results: The search yielded 10 results that met criteria. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000680DOI Listing
April 2019
3 Reads

The Psychological Predictors of Acute and Chronic Pain in Women Following Breast Cancer Surgery: A Systematic Review.

Clin J Pain 2019 Mar;35(3):261-271

School Psychological Sciences and Health, University of Strathclyde.

Objectives: Numerous psychological factors have been found to be associated with acute and chronic pain following breast cancer surgery. However, individual studies tend to be limited to a small number of predictors and many fail to employ prospective designs. This study aimed to identify a broader range of psychological predictors of acute and chronic pain following breast cancer surgery through a systematic review of relevant prospective studies. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000672DOI Listing
March 2019
1 Read

Analgesic Potentials of Preoperative Oral Pregabalin, Intravenous Magnesium Sulphate and their Combination in Acute Post-thoracotomy Pain.

Clin J Pain 2018 Nov 28. Epub 2018 Nov 28.

Anesthesiology and pain relief, National Cancer Institute, Cairo University, Egypt.

Objectives: To investigate the effects of the preoperative combination of oral pregabalin and intravenous magnesium sulphate as analgesic adjuvants in post thoracotomy pain.

Methods: One hundred and twenty patients with ASA physical status II were allocated randomly into one of four groups. Group MP received 300▒mg pregabalin orally and an intravenous (IV) infusion of magnesium sulphate 50▒mg/kg mixed with 200▒mL normal saline (NS); Group P received 300▒mg pregabalin orally and 200▒mL NS infusion; Group M received an IV infusion of magnesium sulphate 50▒mg/kg mixed with 200▒mL NS and a placebo capsule; and Group C received placebo capsule and an IV infusion of 200▒mL NS. Read More

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http://Insights.ovid.com/crossref?an=00002508-900000000-9887
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http://dx.doi.org/10.1097/AJP.0000000000000673DOI Listing
November 2018
21 Reads

Efficacy and Safety of Pregabalin in Neuropathic Pain Followed Spinal Cord Injury: A Review and Meta-Analysis of Randomized Controlled Trials.

Clin J Pain 2019 Mar;35(3):272-278

Department of Orthopaedics.

Objective: Pregabalin has been approved for the treatment of the neuropathic pain following spinal cord injury (SCI). We performed a systemic review and meta-analysis of randomized, controlled, multicenter trials to evaluate the efficacy and safety of pregabalin for SCI-induced neuropathic pain.

Materials And Methods: Research searching was performed in PubMed and EMBASE databases and the Cochrane library in May 2018. Read More

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http://Insights.ovid.com/crossref?an=00002508-900000000-9887
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http://dx.doi.org/10.1097/AJP.0000000000000675DOI Listing
March 2019
3 Reads
2.527 Impact Factor

Cognitive Biases Toward Pain: Implications for a Neurocognitive Processing Perspective in Chronic Pain and its Interaction With Depression.

Clin J Pain 2019 Mar;35(3):252-260

Department of Medical Psychology and Medical Sociology, Faculty of Medicine, Ruhr-University of Bochum, Germany.

Objectives: Information-processing biases such as attentional, interpretation, and memory biases are supposed to play a role in the exacerbation and maintenance of chronic pain. Current research in the area of cognitive biases shows that all these biases seem to have an influence on attention to, interpretation of, and recall of pain and can lead to maladaptive strategies and the exacerbation of pain.

Methods: We conducted a narrative literature review, considering evidence extracted from various databases including PubMed, MEDLINE, Science Direct, and ProQuest. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000674DOI Listing
March 2019
21 Reads

Dexmedetomidine as an Adjuvant to Local Anesthetics in Transversus Abdominis Plane Block: A Systematic Review and Meta-analysis.

Clin J Pain 2019 Apr;35(4):375-384

Department of Anesthesiology.

Objectives: The objective of this meta-analysis was to evaluate the analgesic effects of dexmedetomidine (DEX) in transversus abdominis plane (TAP) blocks for abdominal surgery.

Methods: Electronic databases, including PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), Wan Fang, and the Cochrane Library, were conducted to collect the randomized controlled trials (RCTs) from inception to March 2018. RCTs investigating the impact of adding DEX to local anesthetics for TAP blocks were included in this analysis. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410974PMC
April 2019
1 Read