1,175 results match your criteria The Clinical Respiratory Journal [Journal]


Effects of Exercise-induced Dyspnoea on the Aspiration Rate among Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Clin Respir J 2019 Apr 9. Epub 2019 Apr 9.

State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.

Purpose: To use radionuclide imaging to investigate silent aspiration among patients recovering from an acute exacerbation of chronic obstructive pulmonary disease (AECOPD). We also evaluated the effects of exercise-induced dyspnoea on silent aspiration in COPD patients.

Patients And Methods: Recovering AECOPD patients admitted to the First Affiliated Hospital of Guangzhou Medical University between December 2013 and December 2015 were selected for the radionuclide aspiration test along with healthy volunteers of similar age. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/crj.13030
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http://dx.doi.org/10.1111/crj.13030DOI Listing
April 2019
3 Reads

The v-DECAF score can predict 90 day all-cause mortality in patients with COPD exacerbation requiring invasive mechanical ventilation.

Clin Respir J 2019 Apr 6. Epub 2019 Apr 6.

Department of Emergency and Critical Care Medicine Shanghai Pudong Hospital, Fudan University Pudong Medical Center, postal address:2800 Gongwei Road, Pudong,Shanghai, 201399, China.

Introduction: The DECAF score is a simple and effective tool for predicting mortality in patients hospitalized with acute exacerbations of chronic obstructive pulmonary disease (AECOPD); however, the DECAF score has not been validated in AECOPD patients requiring invasive mechanical ventilation (IMV). We devised the ventilator (v)-DECAF score, in which 'anemia' replaces 'acidaemia', for use in AECOPD patients requiring IMV. The objective of this study was to compare the predictive efficacy of the v-DECAF score and the DECAF score. Read More

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http://dx.doi.org/10.1111/crj.13028DOI Listing
April 2019
2 Reads

Thematic Series: Novel Insights In Pleural Diseases Editorial: Pleural Disease: a continuously improved information.

Clin Respir J 2019 Apr 6. Epub 2019 Apr 6.

Department of Pneumonology and Thoracic Oncology, North Hospital, University Hospital of Saint-Etienne, 42100, Saint-Etienne, France.

Pleural effusion is a frequent manifestation in respiratory medicine and is a major diagnostic and therapeutic problem. In the United States more than 1.5 million patients each year suffer from pleural effusion. Read More

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http://dx.doi.org/10.1111/crj.13029DOI Listing
April 2019
3 Reads

Do the Global Lung Function Initiative reference equations reflect a sample of adult Middle Eastern population ?

Clin Respir J 2019 Apr 5. Epub 2019 Apr 5.

Faculty of Health Sciences and Wellbeing, University of Sunderland, Sunderland, UK.

Introduction: The Global Lung Function Initiative (GLI) 2012 introduced new multi-ethnic spirometry reference values for numerous ethnicities.

Objectives: The aim of this study was to investigate the suitability of the GLI reference values for the adult Jordanian population.

Methods: 1875 (1029 females and 846 males) healthy non-smoking adults were enrolled from several locations in Jordan. Read More

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http://dx.doi.org/10.1111/crj.13027DOI Listing
April 2019
2 Reads

Comparison of the prognostic capability of two comorbidity indices in patients with chronic obstructive pulmonary disease, in real-life clinical practice.

Clin Respir J 2019 Apr 4. Epub 2019 Apr 4.

Pneumology Service, University Hospital Lucus Augusti. Lugo, Spain.

Background: Comorbidities are a major cause of death in chronic obstructive pulmonary disease (COPD). The COPD-comorbidity test (COTE) index was designed to measure comorbidity burden in this disease. The objective of this study was to compare the capability of COTE and the non-COPD specific Charlson comorbidity index (CCI) to predict all-cause mortality in real-life conditions. Read More

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http://dx.doi.org/10.1111/crj.13025DOI Listing
April 2019
1 Read

Triple versus Dual Inhaler therapy in moderate-to-severe COPD: A systematic review and meta-analysis of randomized controlled trials.

Clin Respir J 2019 Apr 4. Epub 2019 Apr 4.

Pulmonary and Critical Care Department, Hurley Medical Center, Michigan State University, Flint, Michigan, United States.

Introduction: Treatment of COPD is evolving specially with triple inhaler therapy.

Objectives: To perform a meta-analysis to ascertain the safety and efficacy of triple inhaler therapy consisting of an inhaled-glucocorticoid (ICS), long-acting muscarinic-antagonist (LAMA), and long-acting β2-agonist (LABA) when compared with dual therapy (ICS-LABA or LAMA-LABA).

Methods: We performed an electronic database search to include randomized controlled trials (RCTs) comparing between triple and dual inhalers. Read More

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http://dx.doi.org/10.1111/crj.13026DOI Listing

Carotid intima-media thickness in chronic obstructive pulmonary disease and survival: A Multicenter Prospective Study.

Clin Respir J 2019 Apr 3. Epub 2019 Apr 3.

Department of Pulmonary Medicine, Selcuk University, Konya, Turkey.

Introduction: Chronic obstructive pulmonary disease (COPD) is associated with increased cardiovascular morbidity and mortality. Carotid intima-media thickness (CIMT) is a non-invasive method assessing atherosclerosis.

Objective: It was aimed to determine relationship and survival between COPD and CIMT. Read More

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http://dx.doi.org/10.1111/crj.13024DOI Listing
April 2019
3 Reads

Noninvasive ventilation and renal replacement therapy in Do-not-Intubate Order critically ill patients: a brief report.

Clin Respir J 2019 Apr 3. Epub 2019 Apr 3.

Alma Mater, Studiorum University of Bologna, Department of Clinical, Integrated and Experimental Medicine (DIMES), Bologna, Italy.

Introduction: Multiple organ failure has been considered a contra-indication for noninvasive ventilation (NIV).

Materials And Methods: We described the outcome of Do-not-Intubate (DNI) patients with Acute Respiratory Failure, treated with NIV and, subsequently, necessitating renal replacement therapy (RRT).

Results And Discussion: 7 patients admitted to our Respiratory Intensive Care Unit, developed Acute Kidney Injury (AKI) during NIV treatment and received RRT for 12. Read More

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http://dx.doi.org/10.1111/crj.13023DOI Listing
April 2019
1 Read

OSA treatment with CPAP: Randomized crossover study comparing tolerance and efficacy with and without humidification by ThermoSmart.

Clin Respir J 2019 Apr 2. Epub 2019 Apr 2.

Centre du sommeil, Hôpital Universitaire Bichat-Claude Bernard, DHU FIRE, AP-HP, Paris, France.

Objectives: Adherence to CPAP remains an issue, as adverse effects (AE) such as rhinitis, dry/congested nose, dry mouth or throat are commonly experienced. The aim of the study was to compare CPAP efficacy and tolerance in severe OSA patients with or without (w/o) heated humidification using the ThermoSmart system.

Methods: multicenter RCT study in which CPAP-naive patients with severe OSA and meeting one or more of the following criteria : >65 years, using >1 drying medication, previous nasal symptoms or nasal surgery, were included. Read More

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http://dx.doi.org/10.1111/crj.13022DOI Listing
April 2019
3 Reads

Impaired glucose tolerance, body mass index and respiratory function in patients with cystic fibrosis: A systematic review.

Clin Respir J 2019 Mar 28. Epub 2019 Mar 28.

Faculty, Nutrition & Dietetics, Department of Human Environmental Studies, Central Michigan University, The Villages, Florida.

Objectives: This systematic review aims to evaluate body mass index (BMI) and forced expiratory volume in one second (FEV ) in patients with cystic fibrosis (CF) diagnosed with impaired glucose tolerance (IGT) compared to those with normal glucose tolerance (NGT). The significance of this topic stems from concern that individuals with CF and IGT may have an overall worse clinical status as indicated by BMI and FEV .

Data Source: An exhaustive literature search was completed between July 2017 and September 2017 using PubMed, CINAHL, Web of Science, Dissertations & Theses, PsycINFO, and Open Grey. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/crj.13019
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http://dx.doi.org/10.1111/crj.13019DOI Listing
March 2019
3 Reads

Single versus bilateral lung transplantation for idiopathic pulmonary fibrosis.

Clin Respir J 2019 Mar 27. Epub 2019 Mar 27.

Transplant Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Jiangsu, China.

Background: Lung transplantation, either single or bilateral, serves as the only effective treatment for end-stage idiopathic pulmonary fibrosis (IPF), but their superiority is still being debated, and its application in Chinese patients has not been data-analyzed.

Methods: We reviewed 109 IPF patients who received lung transplantation at our center between January 1, 2015 and December 31, 2017. The patients were divided into single lung transplantation (SLT) group and bilateral lung transplantation (BLT) group. Read More

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http://dx.doi.org/10.1111/crj.13020DOI Listing
March 2019
1 Read
2.197 Impact Factor

Adverse effect of smoking on cross-sectional area of small pulmonary vessel and arterial stiffness in healthy smokers without COPD.

Clin Respir J 2019 Mar 27. Epub 2019 Mar 27.

Division of Pulmonology, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.

Introduction: Because it induces systemic inflammation, smoking is a risk factor of atherosclerosis and pulmonary hypertension. The brachial-ankle pulse wave velocity (baPWV) and cross-sectional area (CSA) of small pulmonary vessels can be useful markers to assess early changes of arterial stiffness and pulmonary vascular alteration in smokers.

Objectives: This study aimed to explore association between the CSA of small pulmonary vessel and arterial stiffness in healthy male smokers. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/crj.13018
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http://dx.doi.org/10.1111/crj.13018DOI Listing
March 2019
4 Reads
2.197 Impact Factor

Abolishing the venous-arterial CO gradient as treatment for singultus: Commentary on Obuchi et al, 2018.

Clin Respir J 2019 Mar 26. Epub 2019 Mar 26.

Department of Pharmacology & Cell Biology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida.

The recent report in this journal by Toshiro Obuchi et al on CO retention stands out among the many published attempts at offering a solution for an annoying and potentially dangerous symptom, the obstinate hiccup. The authors manage to provide not only a target-guided therapeutic approach (i.e. Read More

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http://dx.doi.org/10.1111/crj.13021DOI Listing
March 2019
1 Read

Diagnosis and management of asthma, COPD and asthma-COPD overlap among primary care physicians and respiratory/allergy specialists: A global survey.

Clin Respir J 2019 Mar 2. Epub 2019 Mar 2.

Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom.

Introduction: Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a heterogenous condition with clinical features shared by both asthma and COPD.

Objectives: This online global survey of respiratory/allergy specialists and primary care practitioners (PCPs) was performed to understand current clinical approaches to the differential diagnosis and management of asthma, COPD and ACO.

Methods: Respondents were recruited through: (a) a global online physician respondent community (49,980 PCPs and 7205 specialists); (b) market research agents; (c) experts; (d) professional societies; (e) colleague invitation. Read More

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http://dx.doi.org/10.1111/crj.13016DOI Listing

Repetitive saliva swallowing test and water swallowing test may identify a COPD phenotype at high risk of exacerbation.

Clin Respir J 2019 Mar 1. Epub 2019 Mar 1.

Department of Respiratory Medicine, Iizuka Hospital, Fukuoka, Japan.

Introduction: Patients with chronic obstructive pulmonary disease (COPD) are known to present with dysphagia from an early stage. Dysphagia leads to swallowing-related complications, in turn leading to COPD exacerbation. Dysphagia screening is recommended; however little is known of its utility in detecting a COPD phenotype at risk for exacerbation. Read More

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http://dx.doi.org/10.1111/crj.13014DOI Listing

Clinical and radiological manifestations of lipoid pneumonia according to etiology: Squalene, omega-3-acid ethyl esters, and idiopathic.

Clin Respir J 2019 Mar 1. Epub 2019 Mar 1.

Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.

Objectives: Clinical manifestations of lipoid pneumonia (LP) vary depending on the causative agents or underlying causes. The aim of the present study was to investigate the clinical and radiological features of LP, classified according to etiologic agents.

Methods: The clinico-radiological characteristics of LP patients were retrospectively compared among groups: exogenous versus idiopathic and squalene versus omega-3-acid ethyl esters (O-3-AEE) versus idiopathic. Read More

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http://dx.doi.org/10.1111/crj.13015DOI Listing
March 2019
1 Read

Screening instrument to identify skin prick test-negative patients with asthma and/or rhinitis.

Clin Respir J 2019 Feb 27. Epub 2019 Feb 27.

Division of Allergy and Clinical Immunology, Department of Chest Diseases, School of Medicine, Hacettepe University, Ankara, Turkey.

Introduction: To the best of our knowledge, there is no prediction tool for determining respiratory allergy in patients with asthma and/or rhinitis.

Objectives: As such, this study aimed to develop an instrument for identifying skin prick test (SPT)-negative patients with asthma and/or rhinitis.

Methods: This cross-sectional study screened 510 consecutive patients diagnosed with asthma and/or rhinitis between November 2009 and May 2011 in Ankara, Turkey. Read More

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http://doi.wiley.com/10.1111/crj.13013
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http://dx.doi.org/10.1111/crj.13013DOI Listing
February 2019
9 Reads

Factors contributing to COPD hospitalisations from 2010 to 2015: Variation among rural and metropolitan Australians.

Clin Respir J 2019 Feb 28. Epub 2019 Feb 28.

Department of Rural Health, The University of Melbourne, Shepparton, Victoria, Australia.

Introduction: Rural and remote populations experience the greatest burden of chronic obstructive pulmonary disease (COPD), the fifth leading cause of death in Australia. Currently there is a need to prioritise health services to improve health outcomes among those at higher risk of COPD.

Objectives: To investigate the differences in COPD hospitalisation between rural and urban populations and determine predictive factors contributing to COPD hospitalisation. Read More

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http://dx.doi.org/10.1111/crj.13012DOI Listing
February 2019
3 Reads

The impact of therapy on the risk of asthma in type 2 diabetes.

Clin Respir J 2019 Feb 27. Epub 2019 Feb 27.

Department of Clinical and Experimental Medicine, University of Surrey, Guildford, United Kingdom.

Background And Objectives: There are limited data about the risk of asthma in people with diabetes. We examined the incidence of asthma in subjects with type 2 diabetes (T2DM) compared to controls, and the association with metformin, sulphonylureas and insulin therapy.

Materials And Methods: We conducted a retrospective cohort study using a representative UK primary care database (N = 894 646 adults). Read More

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http://dx.doi.org/10.1111/crj.13011DOI Listing
February 2019
2 Reads

Intrapleural immunotherapy: An update on emerging treatment strategies for pleural malignancy.

Clin Respir J 2019 Feb 27. Epub 2019 Feb 27.

NYU Pulmonary Oncology Research Team (NYU PORT), Division of Pulmonary, Critical Care, and Sleep Medicine, NYU School of Medicine, NYU Langone Health, New York, New York.

Objectives: Malignant pleural mesothelioma and malignant pleural effusions are a major therapeutic challenge, and are associated with impairment in quality of life and increased mortality. Advances in systemic therapies of malignant pleural mesothelioma have demonstrated limited clinical benefit and there is ongoing interest in intrapleural immunotherapies which have been demonstrated to be well tolerated overall with variable clinical responses. We have reviewed the literature to provide a comprehensive summary of novel intrapleural immunotherapeutic paradigms, including oncolytic virus therapy, gene-mediated cytotoxic immunotherapy, direct cytokine-mediated immunotherapies, innate immunomodulators and adoptive transfer of intrapleural chimeric antigen receptor T-cell therapy. Read More

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http://dx.doi.org/10.1111/crj.13010DOI Listing
February 2019
1 Read

Comparing the effects and compliance between volume-assured and pressure support non-invasive ventilation in patients with chronic respiratory failure.

Clin Respir J 2019 Feb 25. Epub 2019 Feb 25.

Fujian Medical University Union Hospital, Zhongshan Hospital, Fuzhou, China.

Introduction: Standard bi-level non-invasive ventilation with fixed-level pressure support (PS) delivery may not maintain ventilation during the changes in pulmonary mechanics that occur throughout day and night, so average volume-assured pressure support (AVAPS) modes that target a preset volume by adjustment of PS may be effective.

Objective: Our meta-analysis wants to compare AVAPS and pressure support non-invasive ventilation (PS-NIV) regarding arterial blood gases (ABGs), sleep efficiency and compliance.

Method: Relevant publications indexed in PubMed, Cochrane Library, Embase, Web of Science, Wanfang Data, China National Knowledge Infrastructure and VIPI were identified. Read More

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http://dx.doi.org/10.1111/crj.13009DOI Listing
February 2019
1 Read

The effect of atrial fibrillation intervention on nocturnal respiratory events in elderly patients with persistent AF.

Clin Respir J 2019 Feb 21. Epub 2019 Feb 21.

Cardiology Research Department, Eastbourne General Hospital, Eastbourne, United Kingdom.

Background: Sleep-disordered breathing (SDB) and atrial fibrillation (AF) are associated. This study investigated the impact of AF intervention on 6-month home sleep testing data.

Methods: Sixty-seven patients (aged 66 to 86, 53% male) with persistent AF were randomized (1:1:1) to direct current cardioversion (DCCV) (22 patients), permanent pacemaker (PPM) + atrioventricular node ablation (AVNA) + DCCV (22 patients) or AF ablation (23 patients). Read More

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http://dx.doi.org/10.1111/crj.13008DOI Listing
February 2019

Most impactful predictors for hyperoxaemia in exacerbation of chronic obstructive pulmonary disease managed by Emergency Medical Services and Emergency Department.

Clin Respir J 2019 Apr 18;13(4):256-266. Epub 2019 Mar 18.

Emergency Department, Singapore General Hospital, Singapore, Singapore.

Introduction: Hyperoxemia in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) leads to adverse outcomes. It remains prevalent in the pre-hospital Emergency Medical Services (EMS) and Emergency Department (ED).

Objective: To determine the key predictors for hyperoxemia in AECOPD in EMS and ED. Read More

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http://dx.doi.org/10.1111/crj.13007DOI Listing
April 2019
1 Read

Higher serum levels of systemic inflammatory markers are linked to greater inspiratory muscle dysfunction in COPD.

Clin Respir J 2019 Apr 10;13(4):247-255. Epub 2019 Mar 10.

Department of Physical Therapy, University of Miami Miller School of Medicine, Coral Gables, Florida.

Background: Chronic obstructive pulmonary disease (COPD) is associated with an inflammatory response that becomes more pronounced in acute exacerbations. Considerable attention has recently focused on the value of several inflammatory mediators in predicting worsening of COPD-related symptoms. Whereas respiratory muscle dysfunction is also widely present in this population, little is known about how systemic inflammation relates to inspiratory muscle dysfunction in COPD. Read More

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http://dx.doi.org/10.1111/crj.13006DOI Listing
April 2019
1 Read

Novel insights into the systemic treatment of lung cancer malignant pleural effusion.

Clin Respir J 2019 Mar;13(3):131-138

Department of Pneumonology and Thoracic Oncology, North Hospital, University Hospital of Saint-Etienne, Saint-Etienne, France.

Lung cancer is the most common fatal malignancy worldwide. Approximately 75% of non-small-cell lung cancer (NSCLC) patients are diagnosed at an advanced or a metastatic stage. Since 2007, NSCLC patients with malignant pleural effusion (MPE) are staged as M1 disease. Read More

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http://dx.doi.org/10.1111/crj.13005DOI Listing
March 2019
1 Read

Performance of new spirometry reference values in preoperative assessment of lung function.

Clin Respir J 2019 Apr 21;13(4):239-246. Epub 2019 Feb 21.

Department of Anesthesiology and Intensive Care Medicine, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Background: Pulmonary function is not routinely assessed in patients without respiratory disease and symptoms before surgery, even if they are smokers. We aimed to check whether the new spirometric reference values of the worldwide Global Lung Initiative (GLI) affected the preoperative assessment of lung function in allegedly lung-healthy patients compared with the still commonly used old predicted values.

Methods: Two hundred nineteen allegedly lung-healthy non-smokers, past and current smokers were examined by spirometry before elective surgery. Read More

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http://dx.doi.org/10.1111/crj.13004DOI Listing

Cardiac output measurement during exercise in COPD: A comparison of dye dilution and impedance cardiography.

Clin Respir J 2019 Apr 28;13(4):222-231. Epub 2019 Feb 28.

1st Department of Critical Care Medicine and Pulmonary Services, GP Livanos and M Simou Laboratories, Medical School of Athens University, Evangelismos Hospital, Athens, Greece.

Introduction: Impedance cardiography (IC) derived from morphological analysis of the thoracic impedance signal is now commonly used for noninvasive assessment of cardiac output (CO) at rest and during exercise. However, in Chronic Obstructive Pulmonary Disease (COPD), conflicting findings put its accuracy into question.

Objectives: We therefore compared concurrent CO measurements captured by IC (PhysioFlow: CO ) and by the indocyanine green dye dilution method (CO ) in patients with COPD. Read More

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http://dx.doi.org/10.1111/crj.13002DOI Listing
April 2019
4 Reads

Quantification of critical care medicine: An ICU survey.

Clin Respir J 2019 Apr 5;13(4):232-238. Epub 2019 Mar 5.

Division of Pulmonary, Critical Care and Sleep Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.

Background: The shortage in intensivist workforce has been long recognized but no solution has been identified. Meanwhile, fellowships in pulmonary and critical care medicine (PCCM) are expanding, other critical care medicine (CCM) programs are contracting. No explanation exists for this contradictory trend, although understanding contributory factors may lead to a solution for the shortage. Read More

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http://dx.doi.org/10.1111/crj.13003DOI Listing

The predictive value of plasma osmolality for in-hospital mortality in patients with acute pulmonary embolism.

Clin Respir J 2019 Mar 20;13(3):174-183. Epub 2019 Feb 20.

Department of Cardiology, Health Sciences University, Sultan Abdülhamid Han Training and Research Hospital, Istanbul, Turkey.

Introduction And Objectives: Prior studies demonstrated that plasma osmolality may have a predictive value for in-hospital mortality in patients with heart failure and acute coronary syndrome. In addition, plasma glucose and blood urea nitrogen (BUN) levels, the components of plasma osmolality, have been shown to be an important contributor for in-hospital mortality in acute pulmonary embolism (APE) patients. Hence, the objective of the current study is to evaluate the effect of plasma osmolality upon admission with in-hospital mortality in patients with APE. Read More

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http://dx.doi.org/10.1111/crj.13001DOI Listing
March 2019
2 Reads

The role of echocardiographic parameters in predicting survival of patients with lung diseases referred for lung transplantation.

Clin Respir J 2019 Apr 27;13(4):212-221. Epub 2019 Feb 27.

3rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Silesian Centre for Heart Disease, Zabrze, Poland.

Introduction: Idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) show poor prognosis. The importance of left (LV) and right (RV) ventricular morphology and function in patients with end-stage lung diseases referred for lung transplantation (LT) is not well established.

Objectives: To assess whether LV and RV echocardiographic parameters influence survival of patients with IPF, COPD and other interstitial lung diseases (ILD) awaiting LT. Read More

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http://dx.doi.org/10.1111/crj.13000DOI Listing
April 2019
3 Reads

The prognostic role of Gender-Age-Physiology system in idiopathic pulmonary fibrosis patients treated with pirfenidone.

Clin Respir J 2019 Mar;13(3):166-173

Department of Clinical and Biological Sciences, Interstitial and Rare Lung Disease Unit AOU San Luigi Gonzaga, Orbassano, University of Turin, Turin, Italy.

Introduction: Gender, age, physiology (GAP) system have proven to be an easy tool for predicting disease stages and survival in idiopathic pulmonary fibrosis (IPF) patients.

Objective: To validate mortality risk as determined by the GAP system in a real-life multicentre IPF population treated with pirfenidone.

Methods: The study included patients who received pirfenidone for at least 6 months. Read More

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http://dx.doi.org/10.1111/crj.12999DOI Listing
March 2019
12 Reads

Characteristics of cardiopulmonary exercise testing of patients with borderline mean pulmonary artery pressure.

Clin Respir J 2019 Mar 17;13(3):148-158. Epub 2019 Feb 17.

Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Background: Pulmonary hypertension patients with mean pulmonary artery pressure (mPAP) ≥ 25 mm Hg had impaired cardiopulmonary exercise testing (CPET). Borderline mean pulmonary pressures (boPAP; 21-24 mm Hg) represent early pulmonary vasculopathy. The CPET characteristics of boPAP are a matter of discussion. Read More

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http://dx.doi.org/10.1111/crj.12996DOI Listing
March 2019
7 Reads

Disseminated herpes zoster following treatment with benralizumab.

Clin Respir J 2019 Mar 17;13(3):189-191. Epub 2019 Feb 17.

Department of Internal Medicine, Saint Vincent Hospital, Worcester, Massachusetts.

Background: Disseminated herpes zoster infection occurs mostly in immunocompromised hosts. There have been recent reports of disseminated zoster with chemotherapeutic regimens and newer monoclonal antibodies.

Case Report: The present case describes a 61-year-old patient presenting with disseminated herpes zoster after initiation of benralizumab, an anti-IL-5 monoclonal antibody for severe persistent asthma. Read More

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http://dx.doi.org/10.1111/crj.12998DOI Listing
March 2019
10 Reads
2.197 Impact Factor

Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as haematological indices of inflammatory response in ceramic workers' silicosis.

Clin Respir J 2019 Mar 3;13(3):159-165. Epub 2019 Feb 3.

Department of Chest Diseases, Occupational and Environmental Diseases Hospital, Ankara, Turkey.

Introduction: Occupational exposure to crystalline silica over time may result in silicosis: a fatal, irreversible occupational disease leading to lung function impairment. A complex inflammatory process, excessive accumulation of mesenchymal cells and collagen production are the primary mechanisms underlying silicosis. Neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) have emerged as representative indices of systemic inflammation. Read More

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http://dx.doi.org/10.1111/crj.12997DOI Listing
March 2019
7 Reads

Invasive pulmonary aspergillosis in patients with influenza infection: A retrospective study and review of the literature.

Clin Respir J 2019 Apr 18;13(4):202-211. Epub 2019 Mar 18.

Department of Pulmonary and Critical Care Medicine, Centre for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, P.R. China.

Introduction: There has been a rapid increase in the number of influenza and invasive pulmonary aspergillosis (IPA) co-infection.

Objectives: To explore the risk factors and predictors of a poor prognosis in influenza and IPA co-infection.

Methods: We included patients with confirmed influenza during the 2017-2018 influenza season and cases of influenza and IPA co-infection in the literature. Read More

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http://doi.wiley.com/10.1111/crj.12995
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http://dx.doi.org/10.1111/crj.12995DOI Listing
April 2019
11 Reads
2.197 Impact Factor

Temporal trends in survival following ward-based NIV for acute hypercapnic respiratory failure in patients with COPD.

Clin Respir J 2019 Mar 10;13(3):184-188. Epub 2019 Feb 10.

Respiratory Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.

Introduction: Non-invasive ventilation (NIV) is recommended for treatment of acute hypercapnic respiratory failure (AHRF) in acute exacerbations of COPD. National UK audit data suggests that mortality rates are rising in COPD patients treated with NIV.

Objective: To investigate temporal trends in in-hospital mortality in COPD patients undergoing a first episode of ward-based NIV for AHRF. Read More

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http://doi.wiley.com/10.1111/crj.12994
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http://dx.doi.org/10.1111/crj.12994DOI Listing
March 2019
15 Reads

Comparison of prediction value of four bleeding risk scores for pulmonary embolism with anticoagulation: A real-world study in Chinese patients.

Clin Respir J 2019 Mar 28;13(3):139-147. Epub 2019 Feb 28.

Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, P.R. China.

Background: Major bleeding (MB) and clinically relevant bleeding (CRB) are the most common seen complications associated with anticoagulation treatment for pulmonary embolism (PE) patients. A bleeding risk score (BRS) may help to accurately determine the risk of bleeding and make better decisions for patients in clinical practice.

Methods: Patients diagnosed as acute PE and who met the inclusion criteria in Beijing Chao-Yang Hospital from January 2009 to September 2013 were consecutively enrolled. Read More

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http://dx.doi.org/10.1111/crj.12993DOI Listing
March 2019
4 Reads

The effect of isolated nocturnal oxygen desaturations on serum hs-CRP and IL-6 in patients with chronic obstructive pulmonary disease.

Clin Respir J 2019 Feb;13(2):120-124

Division of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, La Jolla, California.

Introduction: A majority of patients with chronic obstructive pulmonary disease (COPD) die of cardiovascular disease (CVD), yet the mechanisms responsible for this association are not fully understood. It remains unknown if isolated nocturnal oxygen desaturation (iNOD) could be one of the potential pathways by which the 'inflammatory COPD' phenotype leads to CVD.

Objectives: We aimed to evaluate if COPD patients who meet the Medicare guidelines for nocturnal oxygen therapy (iNOT+) had higher serum hs-CRP and IL-6 than those who did not meet the guidelines for iNOT (iNOT-). Read More

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http://doi.wiley.com/10.1111/crj.12992
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http://dx.doi.org/10.1111/crj.12992DOI Listing
February 2019
11 Reads

Serum cardiac troponin elevation predicts mortality in patients with pulmonary hypertension: A meta-analysis of eight cohort studies.

Clin Respir J 2019 Feb;13(2):82-91

The People's Hospital of Yuxi City, The 6th Affiliated Hospital of Kunming Medical University, Yuxi, China.

Objective: To determine the association of serum cardiac troponin (cTn) with the mortality of pulmonary hypertension (PH) patients via a meta-analysis.

Date Source: We searched PubMed and EMBASE from inception to October 25, 2017.

Study Selection: The reference lists of the retrieved articles were also consulted. Read More

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http://dx.doi.org/10.1111/crj.12991DOI Listing
February 2019
2 Reads
2.197 Impact Factor

New insights and improved strategies for the management of primary spontaneous pneumothorax.

Clin Respir J 2019 Apr 18;13(4):195-201. Epub 2019 Mar 18.

Centre Valaisan de Pneumologie, Department of Internal Medicine, Montana, Switzerland.

The pathophysiology and management of primary spontaneous pneumothorax (PSP) are a subject of debate. Despite advances in the understanding of its etiopathogenesis and improvements in its management, implementation in clinical practice is suboptimal. In this manuscript, we review the recent literature with a focus on PSP pathophysiology and management. Read More

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http://dx.doi.org/10.1111/crj.12990DOI Listing
April 2019
3 Reads

Lung hypoperfusion in children with complicated pneumonia may be assessed by Doppler ultrasound of the main pulmonary arteries.

Clin Respir J 2019 Feb;13(2):125-128

Pediatric Allergy and Respiratory Unit, Alicante University General Hospital, Alicante, Spain.

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http://dx.doi.org/10.1111/crj.12989DOI Listing
February 2019
2 Reads

Identification of genomic copy number variations in lung benign metastasizing leiomyomatosis.

Clin Respir J 2019 Feb 29;13(2):105-113. Epub 2019 Jan 29.

Servicio de Neumología, Unidad Médica de Alta Especialidad, Hospital de Especialidades del Centro Médico Nacional, Siglo XXI, IMSS, Ciudad de México, México.

Objectives: Lung metastasizing leiomyomatosis (LML) is an infrequently diagnosed pathology developed after sexual maturation, commonly preceded by uterine myomas. Symptoms can include difficulties to breathe, cough, dyspnea and pain, because of mechanical obstruction exerted by expanding local growing leiomyomas. Lung leiomyomas are normally detected by imaging studies, but nowadays the precise diagnosis demands histological characterization of biopsies obtained from the affected tissues. Read More

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http://doi.wiley.com/10.1111/crj.12987
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http://dx.doi.org/10.1111/crj.12987DOI Listing
February 2019
8 Reads

Comparison of two lung cancer screening scores among patients with chronic obstructive pulmonary disease: A community study.

Clin Respir J 2019 Feb;13(2):114-119

Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

Introduction: Based on the National Lung Cancer Screening Trial (NLST), guidelines on screening programs for lung cancer have recommended low-dose computed tomography (LDCT). De Torres et al made a score for COPD patients (COPD-LUCSS) to improve their selection criteria.

Objective: To examine and compare the discriminating value of both scores in a community-based cohort of COPD patients. Read More

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http://dx.doi.org/10.1111/crj.12988DOI Listing
February 2019
1 Read

Small cell lung cancer in the young: Characteristics, diagnosis and outcome data.

Clin Respir J 2019 Feb 28;13(2):98-104. Epub 2019 Jan 28.

Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Background: Patients with small cell lung cancer (SCLC) younger than 40 years are limited in number. Our research aimed to assess the characteristics, diagnosis and outcomes of this patient population.

Methods: Records of patients under the age of 40 with SCLC at the Chinese Academy of Medical Sciences between January 2006 and December 2015 were reviewed and evaluated. Read More

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http://dx.doi.org/10.1111/crj.12986DOI Listing
February 2019
3 Reads

Adequacy of EBUS-TBNA specimen for mutation analysis of lung cancer.

Clin Respir J 2019 Feb;13(2):92-97

Gazi University Medical Faculty, Department of Pathology, Ankara, Turkey.

Objective: Convex probe endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) is a minimally invasive technique with high sensitivity in the mediastinal staging of non-small cell carcinoma (NSCLC). In recent years, molecular testing has been developed to study genetic mutations in NSCLC. There are studies revealing improved survival in advanced NSCLC using targeted therapy as the first-line treatment in these patients. Read More

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http://dx.doi.org/10.1111/crj.12985DOI Listing
February 2019
2 Reads
2.197 Impact Factor

Subglottic perioperative airway-tube inflation via randomized evaluation with variable syringe size (Spair-Tire) study.

Clin Respir J 2019 Jan;13(1):66-69

Department of Anesthesiology, The University of Texas Health Science Center at Houston (UTHealth), McGovern Medical School, Houston, Texas.

Introduction: Risks of endotracheal tube cuff (ETTC) over inflation must be balanced with the need to achieve a minimum pressure of 20 cm H O. Methods have been developed to estimate adequate ETTC pressurization but do not provide accurate endotracheal tube cuff pressure (ETCP) measurements. Hence, different sized syringes may play a role in determining ETCP. Read More

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http://dx.doi.org/10.1111/crj.12984DOI Listing
January 2019
3 Reads

Is there any role for thoracoscopy in the diagnosis of benign pleural effusions.

Clin Respir J 2019 Feb;13(2):73-81

Department of Respiratory Medicine, University Hospital of Evros, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.

Thoracoscopy in the endoscopy suite, has a high diagnostic yield of undiagnosed pleural effusions with minimal and mild complications. Whereas relatively minimal invasive techniques, such as thoracentesis, image-guided pleural biopsy or blind pleural biopsy, can yield sufficient cell or tissue material to establish the diagnosis of the underlying condition, more definite invasive diagnostic and therapeutic procedure, such as thoracoscopy, may be required for accurate sampling and diagnosis, and further provide real-time treatment options in same procedure. If thoracoscopy is considered the gold standard for the diagnosis is a fact in case. Read More

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http://doi.wiley.com/10.1111/crj.12983
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http://dx.doi.org/10.1111/crj.12983DOI Listing
February 2019
12 Reads

Pleura revisited: From histology and pathophysiology to pathology and molecular biology.

Clin Respir J 2019 Jan;13(1):3-13

Department of Pathology, North Hospital, University Hospital of St-Etienne, St-Etienne, France.

Pleural cavity has an interesting physiology that when impaired gives rise to pleural effusions a rather frequent problem in respiratory medicine practice. Their aetiology varies widely producing distinct pathological lesions with different prognosis and treatment. The basic morphological features of pleural diseases, neoplastic and non-neoplastic, will be analysed in this review with an emphasis to their pathophysiology, differential diagnosis and clinicopathological correlations. Read More

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http://dx.doi.org/10.1111/crj.12982DOI Listing
January 2019
1 Read

Could SUVmax be an auxiliary parameter in the clinical management of pulmonary hydatid disease?

Clin Respir J 2019 Jan;13(1):58-65

Department of Pathology, Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey.

Objective: The aim of this study was to investigate the role of 18F-fluorodeoxyglucose positron emission tomography/computerized tomography (FDG-PET/CT) in the diagnosis and treatment of pulmonary hydatid disease and also compare the morphological characteristics of the lesions with SUVmax values and identify complicated disease.

Methods: Thirty-six patients with a diagnosis of pulmonary hydatid disease who underwent 18F-FDG PET/CT imaging were included in this retrospective study. The size of the lesions, morphological characteristics, accompanying parenchymal and pleural findings, SUVmax and HUmean values and FDG uptake in mediastinal lymph nodes were noted. Read More

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http://doi.wiley.com/10.1111/crj.12981
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http://dx.doi.org/10.1111/crj.12981DOI Listing
January 2019
11 Reads

Bibliometric analysis of scientific publications in respiratory journals from China and other top-ranking countries between 2007 and 2017.

Clin Respir J 2019 Jan;13(1):50-57

Department of Respiratory and Critical Care Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.

Introduction: Respiratory disease remains one of the leading causes of mortality and morbidity worldwide.

Objectives: In this study, we aimed to compare the quantity and quality of scientific publications in the field of respirology from the United States, the United Kingdom, Germany, Canada and China.

Methods: Articles published in 58 respiratory journals from 2007 to 2017 were screened with Science Citation Index Expanded database. Read More

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http://dx.doi.org/10.1111/crj.12980DOI Listing
January 2019
1 Read
2.197 Impact Factor