4,441 results match your criteria The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques[Journal]


Psychiatric Neurosurgery: A Survey on the Perceptions of Psychiatrists and Residents.

Can J Neurol Sci 2019 Apr 12:1-8. Epub 2019 Apr 12.

Department of Psychiatry, McGill University Health Center,McGill University,Montreal, Quebec,Canada.

Objectives: To evaluate the attitudes and perceptions of psychiatrists and psychiatry residents regarding neurosurgical procedures for treating psychiatric disorders and to identify potential barriers to patient referral.

Methods: A survey consisting of 25 questions was created using SurveyMonkey and was distributed to psychiatrists and psychiatry residents in Quebec. The study was approved by the McGill University Health Center's Research Ethics Board. Read More

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http://dx.doi.org/10.1017/cjn.2019.5DOI Listing
April 2019
1 Read

Characteristic Cerebrovascular Findings Associated with ACTA2 Gene Mutations.

Can J Neurol Sci 2019 Apr 12:1-2. Epub 2019 Apr 12.

From theDepartment of Radiology,University of Michigan,Ann Arbor, Michigan,USA.

A specific mutation (Arg179) of the ACTA2 gene has previously been described to cause a syndrome of multisystemic smooth muscle dysfunction with an extremely characteristic cerebrovascular appearance.1 Accurate neuroimaging diagnosis of this entity is important as this syndrome predisposes to complications such as early-onset ischemic stroke and ascending thoracic aortic aneurysm.2,3 The following case demonstrates a previously undescribed ACTA2 mutation (Met46) with an identical cerebrovascular imaging appearance to that of Arg179 mutations, but a less severe overall phenotype. Read More

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http://dx.doi.org/10.1017/cjn.2019.20DOI Listing
April 2019
1 Read

Fatal Second Impact Syndrome in Rowan Stringer, A 17-Year-Old Rugby Player.

Can J Neurol Sci 2019 Apr 4:1-4. Epub 2019 Apr 4.

Faculty of Medicine,University of Ottawa,Ottawa, Ontario,Canada.

Second impact syndrome (SIS) is associated with malignant brain swelling and usually occurs in young athletes with one or more prior, recent concussions. SIS is rare and some dispute its existence. We report a case of SIS in Rowan Stringer, age 17, a rugby player who sustained a fatal brain injury despite prompt medical therapy including decompression surgery. Read More

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http://dx.doi.org/10.1017/cjn.2019.14DOI Listing
April 2019
3 Reads

Rowan's Rugby Fatality Prompts Canada's First Concussion Legislation.

Can J Neurol Sci 2019 Apr 4:1-3. Epub 2019 Apr 4.

University of Ottawa Faculty of Medicine,Ottawa, Ontario,Canada.

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http://dx.doi.org/10.1017/cjn.2019.15DOI Listing
April 2019
1 Read

Step on the Gas! Focal Seizures with Autonomic Features.

Can J Neurol Sci 2019 Apr 4:1-3. Epub 2019 Apr 4.

Division of Neurology,University of British Columbia Okanagan,Southern Medical Program, Kelowna, British Columbia,Canada.

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http://dx.doi.org/10.1017/cjn.2019.11DOI Listing
April 2019
2 Reads

Incidentaloma Discoveries in the Course of Neuroimaging Research.

Can J Neurol Sci 2019 Apr 1:1-5. Epub 2019 Apr 1.

Institut universitaire de gériatrie de Montréal,Montreal, Quebec,Canada.

ABSTRACTAmong healthy volunteers in psychiatric brain functional magnetic resonance imaging (fMRI) research studies, the prevalence of incidentalomas can be as high as 34%, of which 10% show clinical significance. An incidentaloma is a lesion found by coincidence without clinical symptoms or suspicion. Like lesions and other types of accidental findings, it is found in healthy individuals recruited to take part in psychiatric studies. Read More

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http://dx.doi.org/10.1017/cjn.2018.397DOI Listing
April 2019
2 Reads

Eagle Syndrome as a Cause of Cerebral Venous Sinus Thrombosis.

Can J Neurol Sci 2019 Apr 1:1-2. Epub 2019 Apr 1.

Department of Neurology, Stroke Center, Neuroscience Center,The First Hospital of Jilin University,Changchun,China.

A 15-year-old teenager presented with a 2-month history of headache. Neurological examination was normal except for papilledema. Further lumbar puncture indicated intracranial hypertension (330 mm H2O). Read More

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http://dx.doi.org/10.1017/cjn.2019.17DOI Listing
April 2019
3 Reads

The Changing Landscape of Treatment for Intracranial Aneurysm.

Can J Neurol Sci 2019 Mar;46(2):159-165

Department of Surgery, Division of Neurosurgery,University of Toronto,Toronto, Ontario,Canada.

There has been a significant transformation in the treatment of intracranial aneurysms (IAs) over the past century, with the most pivotal changes occurring in the past three decades. To characterize this evolution, we assessed the number of articles published on various procedures for the treatment of IA as a measure of their interest and usage over time. We separated our analysis into two main areas: surgical and endovascular approaches. Read More

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http://dx.doi.org/10.1017/cjn.2019.7DOI Listing
March 2019
1 Read
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Prognosis of Cerebral Venous Sinus Thrombosis - Author Response.

Can J Neurol Sci 2019 Mar;46(2):265

Departments of Critical Care Medicine & Clinical Neurosciences,University of Calgary,Calgary, Alberta,Canada.

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http://dx.doi.org/10.1017/cjn.2018.393DOI Listing
March 2019
1 Read

A Survey of Cerebrospinal Fluid Total Protein Upper Limits in Canada: Time for an Update?

Can J Neurol Sci 2019 Mar 27:1-4. Epub 2019 Mar 27.

Division of Neurology, Department of Medicine,The Ottawa Hospital and University of Ottawa,Ottawa, Ontario,Canada.

Background: The antiquated standard reference range of 0.15-0.45 g/L for cerebrospinal fluid total protein (CSF-TP) is well entrenched in medical literature and laboratory operating procedures across the world. Read More

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http://dx.doi.org/10.1017/cjn.2019.12DOI Listing

Factors Associated with Having a Will, Power of Attorney, and Advanced Healthcare Directive in Patients Presenting to a Rural and Remote Memory Clinic.

Can J Neurol Sci 2019 Mar 25:1-12. Epub 2019 Mar 25.

Canadian Centre for Health and Safety in Agriculture, Saskatoon, Saskatchewan,Canada.

Background: A Will, Power of Attorney, and Advanced Healthcare Directive are critical to guide decision-making in patients with dementia. We identified characteristics that are associated with the existence of these documents in patients who presented to a rural and remote memory clinic (RRMC).

Methods: Ninety-five consecutive patients were included in this study. Read More

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http://dx.doi.org/10.1017/cjn.2019.10DOI Listing

Effect of Head Rotation on Jugular Vein Patency Under General Anesthesia.

Can J Neurol Sci 2019 Mar 25:1-3. Epub 2019 Mar 25.

From the Department of Anesthesiology, Perioperative and Pain Medicine,Stanford University School of Medicine,Stanford, CA,USA.

Head rotation causes compression and occlusion of the ipsilateral internal jugular (IJ) vein. This can result in raised intracranial pressure and increased bleeding if the patient is having or has recently had surgery. The amount of head rotation in adults resulting in occlusion of the ipsilateral IJ vein is unknown however. Read More

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http://dx.doi.org/10.1017/cjn.2019.13DOI Listing

Intrathecal Trastuzumab as a Potential Cause of Drug-Induced Aseptic Meningitis.

Can J Neurol Sci 2019 Mar 25:1-2. Epub 2019 Mar 25.

AP-HP,Hôpitaux Universitaires Pitié Salpêtrière -- Charles Foix,Service de Neurologie 2-Mazarin, Paris F-75013,France.

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http://dx.doi.org/10.1017/cjn.2019.21DOI Listing
March 2019
1 Read

Effects of Deep Brain Stimulation of the Subthalamic Nucleus Settings on Voice Quality, Intensity, and Prosody in Parkinson's Disease: Preliminary Evidence for Speech Optimization.

Can J Neurol Sci 2019 Mar 25:1-8. Epub 2019 Mar 25.

Department of Clinical Neurological Sciences,Western University,London, ON,Canada.

Objective: To systematically evaluate how different deep brain stimulation of the subthalamic nucleus (STN-DBS) amplitude, frequency, and pulse-width electrical parameter settings impact speech intensity, voice quality, and prosody of speech in Parkinson's disease (PD).

Methods: Ten individuals with PD receiving bilateral STN-DBS treatments were seen for three baseline and five treatment visits. The five treatment visits involved an examination of the standard clinical settings as well as manipulation of different combinations of frequency (low, mid, and high), pulse width (low, mid, and high), and voltage (low, mid, and high) of stimulation. Read More

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http://dx.doi.org/10.1017/cjn.2019.16DOI Listing
March 2019
2 Reads

Standards of Practice in Acute Ischemic Stroke Intervention International Recommendations.

Can J Neurol Sci 2019 Mar 20:1-6. Epub 2019 Mar 20.

University of Toronto, Toronto Western Hospital,Toronto,Canada.

After five positive randomized controlled trials showed benefit of mechanical thrombectomy in the management of acute ischemic stroke with emergent large-vessel occlusion, a multi-society meeting was organized during the 17th Congress of the World Federation of Interventional and Therapeutic Neuroradiology in October 2017 in Budapest, Hungary. This multi-society meeting was dedicated to establish standards of practice in acute ischemic stroke intervention aiming for a consensus on the minimum requirements for centers providing such treatment. In an ideal situation, all patients would be treated at a center offering a full spectrum of neuroendovascular care (a level 1 center). Read More

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http://dx.doi.org/10.1017/cjn.2019.1DOI Listing

Uric Acid Levels Correlate with Sensory Nerve Function in Healthy Subjects.

Can J Neurol Sci 2019 Mar 18:1-5. Epub 2019 Mar 18.

Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine,University Health Network, University of Toronto,Toronto,Canada.

Background: High levels of uric acid (UA) are associated with various peripheral neuropathies. Furthermore, uric acid levels have been found to correlate with both the clinical and electrophysiological severity of diabetic sensorimotor polyneuropathy, mainly with sensory functions.

Objectives: To determine whether higher UA levels are associated negatively with nerve function in healthy subjects. Read More

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http://dx.doi.org/10.1017/cjn.2019.9DOI Listing
March 2019
1 Read

Intraoperative Flash Visual Evoked Potential Recording and Relationship to Visual Outcome.

Can J Neurol Sci 2019 Mar 14:1-8. Epub 2019 Mar 14.

Department of Surgery, Division of Neurosurgery,The Ottawa Hospital,Ottawa, ON,Canada.

Objective: To determine the relationship between intraoperative flash visual evoked potential (FVEP) monitoring and visual function.

Methods: Intraoperative FVEPs were recorded from electrodes placed in the scalp overlying the visual cortex (Oz) after flashing red light stimulation delivered by Cadwell LED stimulating goggles in 89 patients. Restrictive filtering (typically 10-100 Hz), optimal reject window settings, mastoid reference site, total intravenous anesthetic (TIVA), and stable retinal stimulation (ensured by concomitant electroretinogram [ERG] recording) were used to enhance FVEP reproducibility. Read More

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http://dx.doi.org/10.1017/cjn.2019.4DOI Listing

Clot Histopathology in Ischemic Stroke with Infective Endocarditis.

Can J Neurol Sci 2019 Mar 14:1-6. Epub 2019 Mar 14.

Department of Neurology & Neurophysiology,Liverpool Hospital,Sydney, NSW,Australia.

Background: Endovascular thrombectomy (EVT) has shown efficacy in acute ischemic stroke (AIS) patients with infective endocarditis (IE). The possibility to undertake advanced histopathological clot analysis following EVT offers a new avenue to establish the etiological basis of the stroke - which is often labelled "cryptogenic." In this paper, we present our findings from four consecutive patients with IE who underwent EVT following an AIS at our tertiary referral comprehensive stroke centre. Read More

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https://www.cambridge.org/core/product/identifier/S031716711
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http://dx.doi.org/10.1017/cjn.2019.8DOI Listing
March 2019
7 Reads

Cerebral Venous Sinus Thrombosis in Mid-South USA.

Can J Neurol Sci 2019 Mar 4;46(2):264. Epub 2019 Mar 4.

Division of Critical Care, Department of Anesthesiology,Vanderbilt University Medical Center,Nashville, TN,USA.

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http://dx.doi.org/10.1017/cjn.2018.392DOI Listing
March 2019
1 Read

Cholinergic Neurons in Nucleus Subputaminalis in Primary Progressive Aphasia.

Can J Neurol Sci 2019 Mar 1;46(2):174-183. Epub 2019 Mar 1.

Department of Medical Neuroscience,Dalhousie University,Halifax, Nova Scotia,Canada.

Background: Primary Progressive Aphasia (PPA) is a syndrome characterized by an isolated impairment of language function at disease onset. The cholinergic system is implicated in language function and cholinergic deficits are seen in the brains of individuals with PPA. One major source of cholinergic innervation of the cerebral cortex is the nucleus basalis of Meynert (NBM) within which lies the nucleus subputaminalis (NSP). Read More

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http://dx.doi.org/10.1017/cjn.2019.6DOI Listing
March 2019
1 Read

Living with Migraine in Canada - A National Community-Based Study.

Can J Neurol Sci 2019 Mar 28;46(2):216-223. Epub 2019 Feb 28.

From the Department of Clinical Neurosciences and Hotchkiss Brain Institute,University of Calgary,Calgary, Alberta,Canada.

Objective: To develop a detailed profile of individuals living with migraine in Canada. Such a profile is important for planning and administration of services.

Methods: The 2011-2012 Survey of Living with Neurological Conditions in Canada (SLNCC), a cross-sectional community-based survey, was used to examine a representative sample of migraineurs (N = 949) aged 15 years and older. Read More

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http://dx.doi.org/10.1017/cjn.2019.3DOI Listing
March 2019
4 Reads

The 2018 ter Brugge Lecture: Problems with the Introduction of Innovations in Neurovascular Care.

Can J Neurol Sci 2019 Mar 21;46(2):151-158. Epub 2019 Feb 21.

Division of Neurosurgery, Department of Surgery, Mackenzie Health Sciences Centre,University of Alberta Hospital,Edmonton, Alberta,Canada.

Most endovascular innovations have been introduced into clinical care by showing good outcomes in small enthusiastic case series of selected patients. Randomized clinical trials (RCTs) have rarely been performed, except for acute ischemic stroke, but even then most trial designs were too explanatory to inform clinical decisions. In this article, we review 2 × 2 tables and forest plots that summarize RCT results to examine methodological issues in the design and interpretation of clinical studies. Read More

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http://dx.doi.org/10.1017/cjn.2018.391DOI Listing
March 2019
1 Read

Vitamins and Minerals for Migraine Prophylaxis: A Systematic Review and Meta-analysis.

Can J Neurol Sci 2019 Mar 15;46(2):224-233. Epub 2019 Feb 15.

George & Fay Yee Centre for Healthcare Innovation, Max Rady College of Medicine, Rady Faculty of Health Sciences,University of Manitoba,Winnipeg,Canada.

Objective: To summarize the findings of randomized controlled trials (RCTs) on the efficacy and safety of vitamins and minerals for migraine prophylaxis.

Methods: We systematically searched bibliographic databases and relevant websites for parallel and crossover RCTs reporting efficacy and/or safety of vitamins and/or minerals for migraine prophylaxis. Our primary outcomes were migraine frequency (number of attacks) and duration (hours). Read More

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http://dx.doi.org/10.1017/cjn.2018.394DOI Listing
March 2019
1 Read

Nociceptive Primitive Reflexes in Neurologically and Cognitively Healthy Aging Subjects.

Can J Neurol Sci 2019 Mar 14;46(2):199-208. Epub 2019 Feb 14.

From the Department of Experimental Biomedicine and Clinical Neurosciences,University of Palermo,Palermo,Italy.

Background: To assess the prevalence of three nociceptive primitive reflexes (nPR), i.e., glabellar tap, snout reflex, and palmomental reflex, in neurologically and cognitively healthy (NCH) aging subjects. Read More

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https://www.cambridge.org/core/product/identifier/S031716711
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http://dx.doi.org/10.1017/cjn.2018.388DOI Listing
March 2019
8 Reads

Muscular Ultrasound, Syndecan-1 and Procalcitonin Serum Levels to Assess Intensive Care Unit-Acquired Weakness.

Can J Neurol Sci 2019 Mar 11;46(2):234-242. Epub 2019 Feb 11.

Department of Anaesthesiology and Intensive Care Medicine,University Medical,Center Rostock, Rostock,Germany.

Background: Intensive care unit-acquired weakness (ICU-AW) is associated with poorer outcome of critically ill patients. Microcirculatory changes and altered vascular permeability of skeletal muscles might contribute to the pathogenesis of ICU-AW. Muscular ultrasound (MUS) displays increased muscle echogenicity, although its pathogenesis is uncertain. Read More

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http://dx.doi.org/10.1017/cjn.2018.390DOI Listing
March 2019
6 Reads

Discharge Destination from a Rehabilitation Unit After Acute Ischemic Stroke.

Can J Neurol Sci 2019 Mar 11;46(2):209-215. Epub 2019 Feb 11.

Grey Bruce Health Services,Owen Sound, Ontario,Canada.

Background: We reviewed numerous variables for ischemic stroke patients admitted to a rehabilitation unit to determine those that were statistically associated with discharge destination.

Methods: A retrospective chart review of patients with ischemic stroke discharged from the rehabilitation unit between January 1, 2005 and December 31, 2015. Variables were examined for their association with discharge destination (home versus long-term care (LTC)). Read More

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http://dx.doi.org/10.1017/cjn.2018.386DOI Listing
March 2019
1 Read

Clinical Features of Lewis-Sumner Syndrome: Can Trauma Precipitate Symptoms?

Can J Neurol Sci 2019 Mar 6;46(2):243-247. Epub 2019 Feb 6.

Department of Neurology,Memorial University of Newfoundland,St. John's, Newfoundland,Canada.

Introduction: Lewis-Sumner syndrome (LSS) is a demyelinating peripheral neuropathy described in 1982.

Methods: We reviewed the charts of nine LSS patients in neurological care for their symptoms, response to different treatment regimens, and pattern of nerve involvement.

Results: One patient had an Adie's pupil. Read More

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http://dx.doi.org/10.1017/cjn.2018.389DOI Listing
March 2019
2 Reads

Is the Hypointensity in Motor Cortex the Hallmark of Amyotrophic Lateral Sclerosis?

Can J Neurol Sci 2019 Mar 6;46(2):166-173. Epub 2019 Feb 6.

Laboratory of Clinical Investigation,Instituto Nacional de Neurología y Neurocirugía MVS,Mexico City,Mexico.

Background: Amyotrophic lateral sclerosis (ALS) is a devastating disease that targets motor neurons. Upper motor neurons degeneration is pathologically characterized by brain iron accumulation. Signal attenuation in the shape of a ribbon at the posterior border of the precentral gyrus can be observed on conventional magnetic resonance imaging (MRI) sequences including T2-weighted sequence. Read More

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https://www.cambridge.org/core/product/identifier/S031716711
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http://dx.doi.org/10.1017/cjn.2018.382DOI Listing
March 2019
11 Reads

How Much Sciatic Nerve Does Hip Flexion Require?

Can J Neurol Sci 2019 Mar 30;46(2):248-250. Epub 2019 Jan 30.

Department of Medical Imaging, Sunnybrook Health Sciences Centre,University of Toronto,Toronto, Ontario,Canada.

Measured nerve conduction velocity in the fibular nerve increases across the knee during hip flexion. This is due to stretching of sciatic and fibular nerves. We modeled the additional nerve length required for the sciatic nerve to course around the flexed hip, based upon distance between the hip and the sciatic nerve on magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.1017/cjn.2018.378DOI Listing

Through the Skin, To the Nerves: Subcutaneous Immunoglobulin for Neuromuscular Diseases.

Authors:
Hans D Katzberg

Can J Neurol Sci 2019 01;46(1):1-2

Division of Neurology,University Health Network/University of

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https://www.cambridge.org/core/product/identifier/S031716711
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http://dx.doi.org/10.1017/cjn.2018.383DOI Listing
January 2019
5 Reads

Reply to Richard Leblanc's Letter to the Editor, "Cerebrovascular Neurosurgery in Canada: An Historical Review".

Authors:
Suresh Ramnath

Can J Neurol Sci 2019 01;46(1):123

Department of NeurosurgeryUniversity of Michigan,Ann ArborMI,USA.

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http://dx.doi.org/10.1017/cjn.2018.380DOI Listing
January 2019

Utilization of Spinal Intra-operative Three-dimensional Navigation by Canadian Surgeons and Trainees: A Population-based Time Trend Study.

Can J Neurol Sci 2019 01;46(1):87-95

1Division of Neurosurgery,Department of Surgery,University of Toronto,Toronto,Ontario,Canada.

Background: Computer-assisted navigation (CAN) improves the accuracy of spinal instrumentation in vertebral fractures and degenerative spine disease; however, it is not widely adopted because of lack of training, high capital costs, workflow hindrances, and accuracy concerns. We characterize shifts in the use of spinal CAN over time and across disciplines in a single-payer health system, and assess the impact of intra-operative CAN on trainee proficiency across Canada.

Methods: A prospectively maintained Ontario database of patients undergoing spinal instrumentation from 2005 to 2014 was reviewed retrospectively. Read More

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http://dx.doi.org/10.1017/cjn.2018.376DOI Listing
January 2019
1 Read

An Acute Clinical Presentation Associated with Hypertrophic Olivary Degeneration.

Can J Neurol Sci 2019 01;46(1):137-139

Department of Clinical Neurosciences Cumming School of MedicineUniversity of Calgary,Calgary Alberta,Canada.

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https://www.cambridge.org/core/product/identifier/S031716711
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http://dx.doi.org/10.1017/cjn.2018.375DOI Listing
January 2019
5 Reads

Ischemic Stroke in a Transgender Woman Receiving Estrogen Therapy.

Can J Neurol Sci 2019 01;46(1):145-146

2Department of Neurology,University of TorontoToronto,Canada.

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http://dx.doi.org/10.1017/cjn.2018.374DOI Listing
January 2019

Emergency Embolization of Artery of Adamkiewicz Pseudoaneurysm Following Methylenedioxymethamphetamine Abuse.

Can J Neurol Sci 2019 01;46(1):140-144

2Division of NeurosurgeryVancouver General Hospital,VancouverBC,Canada.

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http://dx.doi.org/10.1017/cjn.2018.372DOI Listing
January 2019
5 Reads

Applying Behavioral Economics and Neuroeconomics to Medical Education and Clinical Care.

Authors:
Gustavo Saposnik

Can J Neurol Sci 2019 01;46(1):35-37

1Department of Economics,University of Zurich.

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http://dx.doi.org/10.1017/cjn.2018.371DOI Listing
January 2019
10 Reads
1.599 Impact Factor

Deep Brain Stimulation as a Rescue When Duodenal Levodopa Infusion Fails.

Can J Neurol Sci 2019 01;46(1):130-131

1Deparment of Medicine (Neurology),University of AlbertaEdmonton, Alberta,Canada.

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http://dx.doi.org/10.1017/cjn.2018.366DOI Listing
January 2019

Evaluation of a Personalized Subcutaneous Immunoglobulin Treatment Program for Neurological Patients.

Can J Neurol Sci 2019 01;46(1):38-43

2Division of Infectious Diseases, Department of Medicine,The Ottawa Hospital,Ottawa, Ontario,Canada.

Background: Subcutaneous immunoglobulin (SCIg) treatment has been shown to control symptoms and improve overall satisfaction in patients with neurological disorders. However, a large injection volume can be overwhelming and a barrier to successful SCIg treatment. We established a nurse-led individualized approach program to facilitate a smooth and successful treatment transition from intravenous immunoglobulin (IVIg) to SCIg. Read More

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http://dx.doi.org/10.1017/cjn.2018.363DOI Listing
January 2019
5 Reads

Persistent Headache Attributed to Traumatic Injury to the Head: Can We Do Better?

Authors:
Werner J Becker

Can J Neurol Sci 2019 01;46(1):3-4

Department of Clinical Neurosciences,University of Calgary,Calgary,AB,Canada(WJB).

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http://dx.doi.org/10.1017/cjn.2018.359DOI Listing
January 2019

Looking Glass Syndromes: Two Sides of the Same Gene.

Can J Neurol Sci 2019 01;46(1):115-120

1Department of Clinical Neurological Sciences,Schulich School of Medicine and Dentistry,Western University,London,Canada.

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http://dx.doi.org/10.1017/cjn.2018.354DOI Listing
January 2019
2 Reads

Nutrients in Alzheimer's Disease: The Interaction of Diet, Drugs and Disease.

Can J Neurol Sci 2019 01;46(1):23-34

1Krembil Research Institute,University Health Network,Toronto,ON,Canada.

In recent decades, clinical trials in Alzheimer's disease (AD) have failed at an unprecedented rate. The etiology of AD has since come under renewed scrutiny, both to elucidate the underlying pathologies and to identify novel therapeutic strategies. Here, diet has emerged as a potential causative/protective agent. Read More

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http://dx.doi.org/10.1017/cjn.2018.353DOI Listing
January 2019
5 Reads

Adherence to Guidelines at a Stroke Prevention Clinic: A Follow-up Study.

Can J Neurol Sci 2019 01;46(1):57-63

1Faculty of Medicine,McGill University,Montreal,Quebec,Canada.

Background: In 2010, we published our stroke prevention clinic's performance as compared to Canadian stroke prevention guidelines. We now compare our clinic's adherence with guidelines to our previous results, following the implementation of an electronic documentation form.

Methods: All new patients referred to our clinic (McGill University Health Center) for recent transient ischemic attack (TIA) or ischemic stroke between 2014 and 2017 were included. Read More

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http://dx.doi.org/10.1017/cjn.2018.352DOI Listing
January 2019
6 Reads
1.599 Impact Factor

Geographic Disparities in the Surgical Management of Hemifacial Spasm in Canada.

Can J Neurol Sci 2019 01;46(1):83-86

1Section of Neurosurgery,University of Manitoba,Winnipeg, Manitoba,Canada(MS, AMK).

Background: We aimed to interrogate the Canadian Institute for Health Information (CIHI) database in order to determine the geographic distribution and outcomes of microvascular decompression (MVD) for the treatment of hemifacial spasm (HFS).

Methods: The CIHI database was searched from 2004 to 2017 for relevant diagnostic and procedure codes. A new database was populated with the following categories: year, institution, province, number of interventions per year, and mean length of stay. Read More

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http://dx.doi.org/10.1017/cjn.2018.350DOI Listing
January 2019

Time Trends of the Incidence, Prevalence, and Mortality of Parkinsonism.

Can J Neurol Sci 2019 Mar 28;46(2):184-191. Epub 2019 Jan 28.

Public Health Ontario,Toronto, Ontario,Canada.

Objectives: We assessed trends in the incidence, prevalence, and post-diagnosis mortality of parkinsonism in Ontario, Canada over 18 years. We also explored the influence of a range of risk factors for brain health on the trend of incident parkinsonism.

Methods: We established an open cohort by linking population-based health administrative databases from 1996 to 2014 in Ontario. Read More

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https://www.cambridge.org/core/product/identifier/S031716711
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http://dx.doi.org/10.1017/cjn.2018.387DOI Listing
March 2019
5 Reads

Phenotypic Variability of Essential Tremor Based on the Age at Onset.

Can J Neurol Sci 2019 Mar 28;46(2):192-198. Epub 2019 Jan 28.

Department of Neurology,National Institute of Mental Health and Neurosciences,Bangalore,India.

Background: Essential tremor (ET) is reported to have a bimodal distribution of age at onset (AAO) with phenotypic variability based on the AAO. This study aims to explore the distribution of AAO based on mathematical modeling and ascertain the differences, if any, in the clinical features of groups.

Methods: A chart review was conducted for 252 patients with ET diagnosed based on the Consensus statement of the Movement Disorder Society on Tremor. Read More

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http://dx.doi.org/10.1017/cjn.2018.384DOI Listing
March 2019
1.599 Impact Factor

Recurrent Herpes Simplex Virus Encephalitis After Epilepsy Surgery.

Can J Neurol Sci 2019 Mar 22;46(2):261-263. Epub 2019 Jan 22.

Department of Clinical Neurosciences,University of Calgary,Calgary,Canada.

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http://dx.doi.org/10.1017/cjn.2018.385DOI Listing
March 2019
2 Reads
1.599 Impact Factor

Application of Automated Brain Segmentation and Fiber Tracking in Hemimegalencephaly.

Can J Neurol Sci 2019 Mar 22;46(2):258-260. Epub 2019 Jan 22.

Division of Neuroradiology, Geneva University Hospital and Faculty of Medicine of Geneva,Geneva,Switzerland.

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http://dx.doi.org/10.1017/cjn.2018.381DOI Listing
March 2019
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Clinical Utility of Longitudinal Measurement of Motor Threshold in Wilson's Disease.

Can J Neurol Sci 2019 Mar 22;46(2):251-254. Epub 2019 Jan 22.

Department of Neurology,National Institute of Mental Health & Neurosciences (NIMHANS),Bangalore,India.

This study describes the longitudinal changes of resting motor threshold (RMT) and central motor conduction time (CMCT) in 18 patients with Wilson's disease (WD). The RMT, CMCT, and Global Assessment Scale for Wilson Disease (GAS-WD) were measured at baseline and at follow-up after 12.94 ± 7. Read More

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http://dx.doi.org/10.1017/cjn.2018.379DOI Listing
March 2019
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Magnetoencephalographic Source Localization of the Eye Area of the Motor Homunculus.

Can J Neurol Sci 2018 Dec 17:1-7. Epub 2018 Dec 17.

1Division of Neurology,Krembil Brain Institute,University Health Network, Toronto Western Hospital,University of Toronto,Toronto, Ontario,Canada.

A patient with intractable epilepsy, previous right frontal resection, and active vagus nerve stimulation (VNS) developed new onset quasi-continuous twitching around the left eye. Electroencephalography showed no correlate to the orbicularis oculi twitches apart from myographic potentials at the left supraorbital and anterior frontal electrodes. Magnetoencephalography was performed using spatiotemporal signal space separation to suppress magnetic artifacts associated with the VNS apparatus. Read More

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https://www.cambridge.org/core/product/identifier/S031716711
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http://dx.doi.org/10.1017/cjn.2018.373DOI Listing
December 2018
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