22,928 results match your criteria The British journal of dermatology[Journal]


Dupilumab provides important clinical benefits to patients with atopic dermatitis who do not achieve clear or almost clear skin according to the Investigator's Global Assessment: a pooled analysis of data from 2 phase III trials.

Br J Dermatol 2019 Feb 21. Epub 2019 Feb 21.

Regeneron Pharmaceuticals, Inc., Tarrytown, NY, U.S.A.

Background: In the US, an Investigator's Global Assessment (IGA) score of ≤ 1 (clear/almost clear skin) has been the regulatory outcome standard measure for registration clinical trials in atopic dermatitis (AD), including those supporting the recent approval of dupilumab.

Objective: To evaluate the treatment effect of dupilumab in patients with IGA>1 at the end of treatment, using other validated outcome measures for AD signs, symptoms and quality of life.

Methods: LIBERTY AD SOLO 1 and 2 were two 16-week, randomized, double-blind trials enrolling adult patients with moderate-to-severe AD (IGA≥3) inadequately controlled with topical treatment. Read More

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http://dx.doi.org/10.1111/bjd.17791DOI Listing
February 2019

Serum cytokeratin 19 fragment 21-1 and carcinoembryonic antigen combination assay as a biomarker of tumour progression and treatment response in extramammary Paget's disease.

Br J Dermatol 2019 Feb 21. Epub 2019 Feb 21.

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.

Background: Extramammary Paget's disease (EMPD) is a rare intraepithelial adenocarcinoma affecting the genitals and axillary regions. As metastasis of these tumours is itself rare, solid disease management strategies have not been established. Serum carcinoembryonic antigen (CEA) and cytokeratin 19 fragment 21-1 (CYFRA 21-1) levels have been identified as candidate biomarkers for tumour progression in EMPD; however, neither the accuracy of, nor correlation between, these markers have been examined in EMPD patients. Read More

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http://dx.doi.org/10.1111/bjd.17789DOI Listing
February 2019

Living with vulval lichen sclerosus: a systematic review.

Br J Dermatol 2019 Feb 21. Epub 2019 Feb 21.

Centre of Evidence Based Dermatology, University of Nottingham, UK.

Lichen sclerosus (LS) is an under-researched disorder, particularly from the perspective of individuals who have the condition. A recent James Lind Alliance Priority Setting Partnership identified uncertainties in many aspects of the condition, including its impact on quality of life which was ranked within the 'Top 10' future research priorities. We set out to systematically review the qualitative literature exploring the lived experience of vulval LS (for the full protocol see PROSPERO ID:CRD42018106947) This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/bjd.17790DOI Listing
February 2019

Chemoradiotherapy could improve overall survival of patients with stage IV cutaneous squamous cell carcinoma: analysis of 34 cases.

Br J Dermatol 2019 Feb 21. Epub 2019 Feb 21.

Department of Dermatology, University of Tsukuba, Tsukuba, Japan.

Cutaneous squamous cell carcinoma (cSCC) is the second most common non-melanoma skin cancer, comprising approximately 20% of all skin malignancies . The prognoses of patients with unresectable disease, such as locally advanced tumour or distant metastases, are known to be relatively poor due to lack of effective standardized systemic therapies . When surgery is not feasible, non-surgical approaches such as chemotherapy, radiation therapy (RT), and chemoradiotherapy (CRT; chemotherapy with radiation), are considered as alternative treatments . Read More

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http://dx.doi.org/10.1111/bjd.17792DOI Listing
February 2019

Not only a Hollywood trend: The dermatologic features of villains in classic and contemporary literature.

Br J Dermatol 2019 Feb 20. Epub 2019 Feb 20.

Dermatology Department, University General Hospital of Patras, Greece.

A disproportional number of movie villains have skin dosorders . However, it is not only in Hollywood that this is over-represented, it is seen in other forms of art and human expression, including classic and contemporary literature. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/bjd.17782DOI Listing
February 2019

Anticipating the Era of Dermatology Disease Trackers.

Br J Dermatol 2019 Feb 20. Epub 2019 Feb 20.

University of Arizona, Department of Medicine, Division of Dermatology, Tucson, AZ, USA.

The current era of patient-centered medicine is characterized by widespread accessibility to medical information and self-driven involvement in disease management. This movement is evident in the rapid expansion of medical mobile applications (apps) for personal electronic devices. Between 2014 and 2017, dermatology-specific mobile apps increased by 81% from 291 to 526, with a growing selection of disease tracking apps for various dermatologic conditions. Read More

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http://dx.doi.org/10.1111/bjd.17635DOI Listing
February 2019

T-VEC in advanced Melanoma - Complete response in a heart and kidney transplant patient: A case report.

Br J Dermatol 2019 Feb 18. Epub 2019 Feb 18.

Departments of 1Dermatology and 2Surgery, Medical University of Vienna, Vienna, Austria.

Talimogene laherparepvec (T-VEC) is a intralesional oncolytic virotherapy, licensed in the European Union (EU) for locoregional advanced melanoma of American Joint Committee on Cancer (AJCC) stages IIIB, IIIC and IVM1a. Organ transplant recipients (OTRs) are so far excluded from all clinical trials dealing with immunotherapies due to the risk of transplant rejection. A 58-year-old caucasian male with a history of a heart and kidney transplantation in 2014 was diagnosed with melanoma (Breslow thickness of 1. Read More

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http://dx.doi.org/10.1111/bjd.17783DOI Listing
February 2019

Eczematous eruption during anti-interleukin 17 treatment of psoriasis: an emerging condition.

Br J Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Health Sciences, University Magna Graecia, Catanzaro, Italy.

Major advances in psoriasis pathogenesis gave rise to development of new effective drugs for its treatment. Particularly, biologic drugs revolutionized disease management. TNF-α inhibitors represented the opening available biologic class since 2000. Read More

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http://dx.doi.org/10.1111/bjd.17779DOI Listing
February 2019

Practice-Based Differences in Pediatric Discoid Lupus Erythematosus.

Br J Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Northwestern University Feinberg School of Medicine, Department of Dermatology and Pediatrics, Chicago, Illinois, United States.

Background: Children with discoid lupus erythematosus (DLE) are at risk for disfigurement and progression to systemic lupus erythematosus (SLE). Consensus is lacking regarding optimal care of children with DLE.

Objectives: We compared practice patterns among pediatric dermatologists/rheumatologists treating pediatric DLE. Read More

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http://dx.doi.org/10.1111/bjd.17780DOI Listing
February 2019
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Conceptual, Statistical and Clinical interpretation of results from A Systematic Review and Meta-Analysis of Cryosurgery combined with Topical interventions for Actinic Keratosis.

Br J Dermatol 2019 Feb 14. Epub 2019 Feb 14.

The University of Adelaide, North Terrace Campus, Adelaide, South Australia, 5005, Australia.

Furthermore, when conducting meta-analysis by pooling studies, the studies should be analysing the outcome of the same input effect (for ex. in a meta-analysis regarding efficacy of two treatments A & B, you cannot pool the results of a cohort that received treatment A with one that received treatment B, even though the outcome of both cohorts is measured in terms of Risk Ratio). Heppt et al. Read More

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http://dx.doi.org/10.1111/bjd.17772DOI Listing
February 2019

Ten Years experience using the Johnson Square Procedure for Lentigo Maligna.

Br J Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, NHS Treatment Centre, Nottingham, UK.

Lentigo maligna (LM) accounts for 4-15% of all melanomas with risk of progression to lentigo maligna melanoma (LMM) estimated to be as high as 20% or as low as 5%. Due to the size, location and sub-clinical spread of these lesions, margin control can be difficult. Clearance rates 24-70% have been reported when using standard excision with 5mm margins and bread-loaf histological processing Recurrence rates of 7-20%. Read More

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http://doi.wiley.com/10.1111/bjd.17774
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http://dx.doi.org/10.1111/bjd.17774DOI Listing
February 2019
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Disease trajectories in childhood atopic dermatitis: an update and practitioner's guide.

Br J Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Regeneron Pharmaceuticals, Inc, Tarrytown, NY, U.S.A.

Background: Atopic dermatitis (AD) is a heterogeneous disease with a multifactorial aetiology and complex pathophysiology. This heterogeneity translates into different trajectories of disease progression with respect to severity, persistence, and risk of development of atopic comorbidities. Determining which possible disease trajectories or comorbidities any individual child might develop is challenging in clinical practice. Read More

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http://dx.doi.org/10.1111/bjd.17766DOI Listing
February 2019

Hidden treasures: Exploring selective publication of trials and trial outcomes in biologic treatment for plaque psoriasis.

Br J Dermatol 2019 Feb 13. Epub 2019 Feb 13.

St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Studies with statistically significant positive results are more likely to be published than studies with negative or inconclusive results (1). An example in dermatology were the studies with imiquimod for viral warts, which were 'negative' but never published by the funding pharmaceutical companies (2). By comparing published data to publically accessible data held by the Food and Drug Administration (FDA), Turner et al. Read More

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http://dx.doi.org/10.1111/bjd.17773DOI Listing
February 2019

Reproductive factors and risk of melanoma: a population-based cohort study.

Br J Dermatol 2019 Feb 12. Epub 2019 Feb 12.

Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.

Background: The association between reproductive factors and risk of cutaneous melanoma (CM) is unclear. We investigated this issue in the Norwegian Women and Cancer (NOWAC) cohort study.

Objectives: To examine the association between the reproductive factors age at menarche, menstrual cycle length, parity, age at first and last birth, menopausal status, breastfeeding duration and length of ovulatory life and CM risk, overall and by histological subtypes and anatomical site METHODS: We followed 165,712 women aged 30-75 at inclusion from 1991-2007 to the end of 2015. Read More

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http://dx.doi.org/10.1111/bjd.17771DOI Listing
February 2019

Surveillance for familial melanoma: recommendations from a national centre of expertise.

Br J Dermatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.

An estimated 10% of patients diagnosed with melanoma have a positive family history for this cutaneous malignancy. Familial melanoma is arbitrarily defined as the occurrence of three or more melanomas in multiple members of a family, at least two of which are diagnosed in first-degree relatives. The pedigrees of these families are compatible with an autosomal dominant mode of inheritance. Read More

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http://dx.doi.org/10.1111/bjd.17767DOI Listing
February 2019

Photoacoustic imaging as an innovative technique for the exploration of Blue Rubber Bleb Nevus.

Br J Dermatol 2019 Feb 11. Epub 2019 Feb 11.

Institute for Advanced Biosciences, Univ. of Grenoble Alpes, INSERM U1209 and CNRS UMR5309, 38000, Grenoble, France.

Blue rubber bleb nevus syndrome (BRBN, Bean syndrome) is a rare vascular malformation (VM) characterized by multiple cutaneous and mucous venous defects disseminated throughout the body. An infringement of mucous membranes is possible with potential complications as anemia or hemorrhage. Photoacoustic imaging (PAI) is an emerging technology combining the most compelling features of optical imaging and ultrasound, providing both high optical contrast and high ultrasound resolution at depth in living organisms . Read More

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http://doi.wiley.com/10.1111/bjd.17765
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http://dx.doi.org/10.1111/bjd.17765DOI Listing
February 2019
7 Reads

Long-term, real world, efficacy of biologics for psoriasis: a single centre's experience.

Br J Dermatol 2019 Feb 9. Epub 2019 Feb 9.

The Dermatology Centre, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester NIHR Biomedical Research Centre, Manchester Academic Health Science Centre, M6 8HD, UK.

Biologic therapies have revolutionised the management of moderate to severe chronic plaque psoriasis and have been life-transforming for many patients. The first biologic to be licensed for psoriasis in the UK was efalizumab in 2004 and there are now nine licensed by the European Medicines Agency for the indication of moderate-severe disease. A key determinant in choosing a biologic for an individual patient is the likelihood of long-term efficacy and for some there is compelling evidence that monotherapy can result in long-term disease control. Read More

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http://dx.doi.org/10.1111/bjd.17756DOI Listing
February 2019

Engagement can increase patient willingness to take medications.

Br J Dermatol 2019 Feb 9. Epub 2019 Feb 9.

Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

DEAR EDITOR, Patients are often unduly afraid of rare or non-existent but perceived risks of starting a new medication. Developing and testing specific approaches to overcome such fears may help improve patients' treatment outcomes. We hypothesized that engaging patients in thinking about how to present reassuring information could be used to modify patients' perceptions of treatment. Read More

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http://dx.doi.org/10.1111/bjd.17757DOI Listing
February 2019
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The nasal and skin microbiome are associated with disease severity in pediatric atopic dermatitis.

Br J Dermatol 2019 Feb 9. Epub 2019 Feb 9.

Department of Dermatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Alterations of the skin microbiome have been associated with atopic dermatitis (AD) and its severity. The nasal microbiome in relation to AD severity is less well studied.

Objective: We aimed to characterize the nasal and skin microbiome in children with AD in relation to disease severity. Read More

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http://dx.doi.org/10.1111/bjd.17755DOI Listing
February 2019

PRISModegib: the use of the PRISM test to assess the Health-Related Quality of Life of patients with Locally Advanced Basal Cell Carcinoma undergoing Hedgehog Pathway Inhibitor Therapy.

Br J Dermatol 2019 Feb 9. Epub 2019 Feb 9.

Department of Dermatology, ASST degli Spedali Civili, Spedali Civili di Brescia, Brescia, Italy.

Vismodegib is an Hedgehog Pathway Inhibitor Therapy (HPIT) for patients affected by Locally Advanced Basal Cell Carcinoma (laBCC) and Metastatic Basal Cell Carcinoma (mBCC) not eligible for surgery and/or radiotherapy . The efficacy of Vismodegib has been reported by several studies; likewise, treatment-emergent adverse effects (AEs) have been reported for 95-100% of the patients . It has been observed that patients who achieved complete or partial response often discontinued HPIT because of a grade 1 or 2 AEs. Read More

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http://dx.doi.org/10.1111/bjd.17754DOI Listing
February 2019

Association analysis within MHC region of psoriasis vulgaris accounting for familial history.

Br J Dermatol 2019 Feb 8. Epub 2019 Feb 8.

Institute of Dermatology and Department of Dermatology of the First Affiliated Hospital, Anhui Medical University, Hefei, 230032, Anhui, China.

Psoriasis vulgaris (PsV) is the most common subtype of psoriasis which only involved the skin and without joint symptoms, and both environmental and genetic factors were involved in its etiology . Some patients have familial genetic predisposition, more than 80 susceptibility genes/loci have been identified . Human leukocyte antigen system (HLA) has been identified to be significantly associated with psoriasis and explained vital part of the genetic factors in pathogenesis of psoriasis . Read More

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http://dx.doi.org/10.1111/bjd.17747DOI Listing
February 2019

CD8 resident memory T cells with IL-17A-producing potential are accumulated in disease-naïve non-lesional sites of psoriasis possibly in correlation with disease duration.

Br J Dermatol 2019 Feb 8. Epub 2019 Feb 8.

Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Human skin is populated by non-recirculating resident memory T cells (T ) which are characterized by the expression of surface molecules such as CD49a, CD69 and CD103 . In psoriasis, CD8 T in lesional (L) and resolved skin demonstrate IL-17-skewed phenotype . A skin-grafted mouse model also proved the importance of CD8 T cells in disease initiation . Read More

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http://dx.doi.org/10.1111/bjd.17748DOI Listing
February 2019

Efficacy and Safety of Mirikizumab (LY3074828) in the Treatment of Moderate-to-Severe Plaque Psoriasis: Results from a Randomised Phase 2 Study.

Br J Dermatol 2019 Feb 7. Epub 2019 Feb 7.

Probity Medical Research, Waterloo, ON, Canada.

Background And Objectives: Inhibiting the interleukin (IL)-23 cytokine in patients with psoriasis has demonstrated high levels of skin clearance. In this Phase 2 (AMAF, NCT02899988), multicentre, double-blind trial, we investigated the efficacy and safety of three dose groups of mirikizumab (LY3074828), a p19-directed IL-23 antibody, compared to placebo in patients with moderate-to-severe plaque psoriasis.

Methods: Adult patients were randomised 1:1:1:1 to receive placebo (N=52), mirikizumab 30 mg (N=51), 100 mg (N=51), or 300 mg (N=51) subcutaneously at Weeks 0 and 8. Read More

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http://dx.doi.org/10.1111/bjd.17628DOI Listing
February 2019

Does weight loss reduce the severity and incidence of psoriasis or psoriatic arthritis? A critically-appraised topic.

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Clinical Question: Does weight loss reduce the severity and incidence of psoriasis or psoriatic arthritis (PsA) in obese individuals?

Background: Obesity presents a rising public health challenge and is more prevalent amongst individuals with psoriasis or PsA compared to the general population. Longitudinal population-based studies suggest a causal role for obesity in psoriasis and PsA onset and that obesity drives greater disease severity.

Methods: We systematically reviewed evidence within Medline/EMBASE/CENTRAL databases and clinical trials registries examining lifestyle, pharmacological and surgical weight loss interventions in the treatment and prevention of psoriasis and PsA in obese individuals. Read More

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http://dx.doi.org/10.1111/bjd.17741DOI Listing
February 2019
4 Reads

Objective assessment of dermal fibrosis in cutaneous scarring: using optical coherence tomography, high frequency ultrasound and immuno-histo-morphometry of human skin.

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Plastic and Reconstructive Surgery Research, Centre for Dermatology Research, Division of Musculoskeletal and Dermatological Sciences, NIHR Manchester Biomedical Research Centre, The University of Manchester, Manchester, United Kingdom.

Background: Non-invasive quantitative assessment of dermal fibrosis remains a challenge. Optical coherence tomography (OCT) and high-frequency ultrasound (HFUS) can accurately measure structural and physiological changes in skin.

Objectives: To perform quantitative analysis of cutaneous fibrosis. Read More

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http://dx.doi.org/10.1111/bjd.17739DOI Listing
February 2019
1 Read

Insights on an in vivo model for postinflammatory hyperpigmentation.

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology, Henry Ford Hospital, Detroit, MI.

Postinflammatory hyperpigmentation (PIH) can occur following a multitude of inflammatory skin conditions including acne vulgaris. It is more common in darker Fitzpatrick phototypes and represents a common skin complaint in dermatology offices. Despite its common occurrence, treatment options for PIH remain limited. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.17746
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http://dx.doi.org/10.1111/bjd.17746DOI Listing
February 2019
4 Reads

Construct validity and responsiveness of the Colombian version of Skindex-29.

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Institute of Medical Research, School of Medicine, University of Antioquia, Medellín, Colombia.

Background: In recent years, the need for international objective Patient-Reported-Outcomes measures has grown, as international collaboration has increased. As most Quality of Life scales have been developed in English, there is a growing need to adapt them transculturally to obtain equivalence between the original instrument and the adapted scale.

Aim: To assess the construct and convergent/discriminant validity and responsiveness of the Colombian version of Skindex-29. Read More

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http://dx.doi.org/10.1111/bjd.17742DOI Listing
February 2019

Evaluation of subclinical gut inflammation using fecal calprotectin levels and colonic mucosal biopsy in psoriasis and psoriatic arthritis patients.

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Gastroenterology, India.

Relationship between the joint disease and the gut inflammation has been established in axial spondyloarthritis(SpA). However this is not well established in Psoriatic arthritis(PsA). Our aim was to compare gut inflammation in psoriasis (PsO), PsA and irritable bowel syndrome(IBS) using fecal calprotectin assay which is a non-invasive tool. Read More

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http://dx.doi.org/10.1111/bjd.17745DOI Listing
February 2019
1 Read

Factors Predicting Persistence of Biologic Drugs in Psoriasis: A Systematic Review and Meta-Analysis.

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Division of Dermatology, Department of Medicine, University of Alberta, Alberta, Canada.

Background: Long-term therapy of psoriasis is impaired by gradual loss of effectiveness and treatment discontinuation. Identifying factors that affect biologic drug survival may help in treatment optimization.

Objectives: To identify factors that predicted biologic drug persistence or discontinuation in a real-life setting. Read More

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http://dx.doi.org/10.1111/bjd.17738DOI Listing
February 2019
1 Read

Peak Pruritus Numerical Rating Scale: Psychometric Validation and Responder Definition for Assessing Itch in Moderate-To-Severe Atopic Dermatitis.

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Regeneron Pharmaceuticals, Tarrytown, NY, U.S.A.

Background: Moderate-to-severe atopic dermatitis (AD) is a chronic disease characterised by intense, persistent, and debilitating itch, resulting in sleep deprivation, signs of anxiety and depression, impaired quality of life and reduced productivity. The Peak Pruritus Numerical Rating Scale (NRS) was developed and validated as a single-item, patient-reported outcome (PRO) of itch severity.

Objectives: To describe the content validity and psychometric assessment (test-retest reliability, construct validity, known-groups validity, sensitivity to change) of the Peak Pruritus NRS, and to empirically derive a responder definition to identify adults with a meaningful change in itch. Read More

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http://dx.doi.org/10.1111/bjd.17744DOI Listing
February 2019

Dermoscopy for the diagnosis of eyelid margin tumours.

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Ophthalmology, University Hospital of Saint-Etienne, 42055 Saint-Etienne Cedex 2, France.

There are only case reports concerning dermoscopy of eyelid margin tumours. We evaluated the clinical and dermoscopic features of 165 eyelid margin tumours of 145 consecutive patients (77 females, 68 males, mean age 64·3 years, standard deviation - SD 17·94, range 10 - 95 years) recruited at the Dermatology Department of the University Hospital of Saint-Etienne, France, between September 1st, 2013 and January 30th, 2017 to exclude malignant tumours. This article is protected by copyright. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.17743
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http://dx.doi.org/10.1111/bjd.17743DOI Listing
February 2019
2 Reads

Micrographic controlled surgery of basal cell carcinomas - Rapid Lump Examination (RLE) in comparison to H&E-stained paraffin sections.

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology, University Hospital, Liebermeisterstraße 25, D-72076, Tuebingen.

The most common skin cancer is basal cell carcinoma (BCC). As the incidence of BCC is increasing, it is of major interest to optimize diagnostic and therapeutic options. The most effective option for complete clearance is through surgical treatment. Read More

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http://dx.doi.org/10.1111/bjd.17740DOI Listing
February 2019

The sentinel node biopsy has come of age.

Authors:
J M McGregor

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Dept of Dermatology, Royal London Hospital, Barts Health NHS Trust, London, E1 1BB.

In 2015, Peter Sasieini and I wrote an editorial on the sentinel node biopsy, calling for consensus on its use in clinical practice. At that time, despite controversial claims of a survival advantage, it was broadly considered a staging procedure. It provided prognostic information, reduced the trauma of nodal relapse in node positive patients and provided some reassurance for those with a negative node who were able to avoid elective completion lymphadenectomy. Read More

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http://dx.doi.org/10.1111/bjd.17737DOI Listing
February 2019

Interrater agreement and reliability of outcome measurement instruments and staging systems used in hidradenitis suppurativa.

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology, Zealand University Hospital, Roskilde, Health Sciences Faculty, University of Copenhagen, Denmark.

Background: Monitoring disease activity over time is a prerequisite for clinical practice and research. Valid and reliable outcome measurements instruments (OMIs) and staging systems provide researchers and clinicians with benchmark tools to assess the primary and secondary outcomes of interventional trials and to guide treatment selection properly.

Objectives: To investigate interrater reliability and agreement in instruments currently used in Hidradenitis Suppurativa (HS) with HS-experienced dermatologists being the rater population of interest. Read More

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http://dx.doi.org/10.1111/bjd.17716DOI Listing
February 2019

Late ulceration of residual abortive infantile hemangioma: a rare complication.

Br J Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Dermatology and Reference center for Genodermatoses and Rare Skin Diseases (MAGEC), Université Paris Descartes - Sorbonne Paris Cité, Institut Imagine, Hôpital Universitaire Necker-Enfants Malades, APHP, Paris, France.

Abortive and minimal growth infantile hemangiomas (IH) are present at birth and have a proliferative component of less than 25% of their total surface. Clinically, they appear most frequently as a telangiectatic patch with venules, surrounded by a halo of vasoconstriction. They may be large or small, segmental or focal. Read More

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http://dx.doi.org/10.1111/bjd.17717DOI Listing
February 2019
1 Read

TREatment of ATopic eczema (TREAT) Registry Taskforce: consensus on how and when to measure the core dataset for atopic eczema treatment research registries.

Br J Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Unit for Population-Based Dermatology Research, St John's Institute of Dermatology, Guy's& St Thomas' NHS Foundation Trust and King's College London, London, UK.

Background: Comparative, real-life and long-term evidence on the effectiveness and safety of photo- and systemic therapy in moderate-to-severe atopic eczema (AE) is limited. Such data must come from well-designed prospective patient registries. Standardisation of data collection is needed for direct comparisons and data pooling. Read More

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http://dx.doi.org/10.1111/bjd.17715DOI Listing
February 2019

Clearance of molluscum contagiosum virus infection in patients with atopic eczema treated with dupilumab.

Br J Dermatol 2019 Feb 4. Epub 2019 Feb 4.

St. John's Institute of Dermatology, Guy's and St, Thomas NHS Foundation Trust, London, UK.

Molluscum contagiosum virus (MCV) infection in the setting of atopic dermatitis (AD), also known as eczema molluscatum, can represent a significant treatment challenge to the dermatologist. We report four patients with severe AD and disseminated MCV infection who experienced clearance of their MCV infection following treatment with dupilumab, a fully human monoclonal antibody against interleukin(IL)-4 receptor alpha licenced for the treatment of moderate to severe AD. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/bjd.17712DOI Listing
February 2019

Improvement of atopic dermatitis with dupilumab occurs equally well across different anatomic regions: data from phase 3 clinical trials.

Br J Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Regeneron Pharmaceuticals, Inc, Tarrytown, NY, USA.

Moderate-to-severe atopic dermatitis (AD) can affect different parts of the body, and some adults have more localized AD, such as face and neck involvement. Compared with non-exposed areas, such as the trunk, exposed areas such as the face, neck, and hands could be more vulnerable to environmental allergens and irritants and can be more refractory to topical therapies. Local adverse effects of topical therapies are more likely to occur on the face and neck. Read More

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http://dx.doi.org/10.1111/bjd.17703DOI Listing
February 2019
2 Reads

T-cell responses against 4-tertiarybutylphenol-exposed pigmented cells in a patient with occupational vitiligo.

Br J Dermatol 2019 Feb 5. Epub 2019 Feb 5.

Department of Dermatology and Netherlands Institute for Pigment Disorders, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Infection& Immunity Institute, Cancer Center Amsterdam, Amsterdam, Netherlands.

Several case studies on contact/occupational vitiligo after skin contact with 4-tertiairybutylphenol (4-TBP) have been reported. Biochemical and cellular effects of 4-TBP on melanocytes have been shown in vitro, but immunological analyses explaining the immunising ability of 4-TBP leading to wide-spread vitiligo lesions beyond areas of primary contact are still lacking. We report here the presence of a systemic T-cell response to 4-TBP-exposed pigmented cells in a patient with chemically-induced vitiligo. Read More

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http://dx.doi.org/10.1111/bjd.17713DOI Listing
February 2019

Nine percent of biopsy proven lentigo maligna are reclassified as lentigo maligna melanoma after surgery.

Br J Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Department of Dermatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Lentigo maligna (LM) is a melanoma in situ and the incidence is still rising in The Netherlands. LM is mostly located in the face, therefore radical surgical removal, which is the first choice of treatment, can be challenging in this delicate anatomical region. Staged excision is considered a useful alternative. Read More

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http://dx.doi.org/10.1111/bjd.17714DOI Listing
February 2019

Refining the ever-evolving molecular landscape of spitzoid melanocytic neoplasms.

Authors:
M P Chan

Br J Dermatol 2019 Feb;180(2):262

Departments of Pathology and Dermatology, University of Michigan, Ann Arbor, MI, U.S.A.

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http://dx.doi.org/10.1111/bjd.17115DOI Listing
February 2019

Image Gallery: Acquired anhidrosis associated with alcohol-related peripheral neuropathy, a potential cause of anhidrosis due to reduced innervation of eccrine glands.

Br J Dermatol 2019 Feb;180(2):e35

Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

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http://dx.doi.org/10.1111/bjd.17247DOI Listing
February 2019

BJD Medical Student Editors: reaching out to undergraduates in a rapidly evolving world of digital dermatology publishing.

Br J Dermatol 2019 Feb;180(2):251-252

Department of Dermatology, Division of Infection and Immunity, Cardiff University, Cardiff, U.K.

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http://dx.doi.org/10.1111/bjd.17397DOI Listing
February 2019
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Is the routine screening for hyperhomocysteinaemia recommended in patients with chronic plaque psoriasis?

Authors:
P Gisondi

Br J Dermatol 2019 Feb;180(2):262-263

Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy.

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http://dx.doi.org/10.1111/bjd.17357DOI Listing
February 2019

Bakuchiol may be another natural solution to reverse the course of nature.

Authors:
H Lev-Tov

Br J Dermatol 2019 Feb;180(2):253-254

Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, FL,, U.S.A.

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http://dx.doi.org/10.1111/bjd.17438DOI Listing
February 2019

Alexithymia and psoriasis: what is the link?

Authors:
L Misery

Br J Dermatol 2019 Feb;180(2):261

Department of Dermatology, University Hospital of Brest, Brest, France.

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http://dx.doi.org/10.1111/bjd.17412DOI Listing
February 2019

Who likes to perform the Psoriasis Area and Severity Index?

Br J Dermatol 2019 Feb;180(2):260-261

Division of Dermatology, Department of Medicine, J.H. Stroger Jr Hospital of Cook County, 1900 West Polk Street, Chicago, IL, 60612, U.S.A.

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http://dx.doi.org/10.1111/bjd.17441DOI Listing
February 2019

Image Gallery: Spoon-shaped nails in an 11-year-old boy.

Br J Dermatol 2019 Feb;180(2):e34

Hospital Universitario 12 de Octubre - Dermatology, Avenida de Córdoba s/n, Madrid, 28041, Spain.

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http://dx.doi.org/10.1111/bjd.17248DOI Listing
February 2019

Consensus, collaboration and care coordination.

Authors:
M L Levy

Br J Dermatol 2019 Feb;180(2):253

Dell Medical School, University of Texas at Austin, Dell Children's Medical Center, Austin, TX, U.S.A.

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http://dx.doi.org/10.1111/bjd.17439DOI Listing
February 2019

Influence on contact allergy of immune-mediated skin diseases such as psoriasis.

Authors:
C Erfurt-Berge

Br J Dermatol 2019 Feb;180(2):256-257

Department of Dermatology, University Hospital Erlangen, Erlangen, Germany.

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http://dx.doi.org/10.1111/bjd.17413DOI Listing
February 2019