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Br J Neurosurg 2022 Jun 24:1-4. Epub 2022 Jun 24.

Department of Neurosurgery, Oita University Faculty of Medicine, Oita, Japan.

-induced mycotic aneurysm is difficult to treat and often has poor outcomes with severe symptom progression. Early diagnosis is also difficult, and blood and cerebrospinal fluid tests often fail to reveal any findings. A 74-year-old man presented with recurrent nosebleeds in addition to symptoms of left optic neuritis. Read More

Cureus 2022 May 20;14(5):e25153. Epub 2022 May 20.

Department of General Internal Medicine, Kobe University Hospital, Kobe, JPN.

A 76-year-old man presented with a four-month history of progressive bilateral lower limb muscle weakness and dysesthesia. The patient had extravascular volume overload, and laboratory findings confirmed hypothyroidism, renal dysfunction, and chronic inflammation. Serum protein and immunofixation electrophoresis revealed biclonality of immunoglobulin A (IgA)-kappa and IgA-lambda, which was attributed to chronic inflammation. Read More

Ann Med Surg (Lond) 2022 Jun 29;78:103853. Epub 2022 May 29.

Mercy Health Pulmonary Disease Center, St. Rita's Medical Center, Lima, OH, USA.

Introduction And Importance: Pulmonary artery aneurysms are rare anomalies of the pulmonary vasculature. They are often asymptomatic and frequently an incidental finding on imaging or autopsy. It is imperative to closely monitor pulmonary artery aneurysms as they can result in sudden dissection, rupture, and death. Read More

Ann Med Surg (Lond) 2022 Jun 4;78:103932. Epub 2022 Jun 4.

Department of Surgery-University of Dodoma, School of Medicine and Dentistry, Dodoma, Tanzania.

Introduction: and importance: Ruptured esophageal varices are fatal and cause haemorrhagic shock and consequently death if no immediate intervention is instituted to arrest bleeding. The role of forensic pathologists in investigating cases of sudden unexpected deaths is of paramount importance. Upon medico-legal work ups by forensic pathologists, autopsy would shed light to the exact cause of death as to whether it is natural or unnatural. Read More

Ann Med Surg (Lond) 2022 Jun 4;78:103920. Epub 2022 Jun 4.

Department of Internal Medicine. Grand Strand Medical Center, Myrtle Beach, SC, 29572, USA.

Introduction: and Importance: Melanomas are capable of metastasizing to both regional and distant sites and are notably known to metastasize to the skin, lungs, brain, liver, bone, and gastrointestinal tract. Metastatic melanoma is infrequently diagnosed , and usually found only on evaluation at autopsy.

Case Presentation: Here we present the case of a 64-year-old male who originally presented with melena, fatigue, exertional dyspnea and one episode of near-syncope. Read More

Ann Med Surg (Lond) 2022 Jun 28;78:103658. Epub 2022 Apr 28.

Faculty of Medicine, Aleppo University, Aleppo, Syria.

Introduction: Pulmonary tuberculosis is a disease that may effect on many organs such as the lung, peritoneum and spread to adjacent lymph nodes in advanced stages, but it is rarely to be as an isolated lymph node without accompanying pulmonary or extra pulmonary tuberculosis in healthy persons.

Case Presentation: A 40 -Years-female presented with a chief complaint of Pain in the lateral side of the Right humerus above the elbow, with no medical history, on clinical examination there was a painful palpable mass in mentioned place. The mass was removed surgically under local anesthesia and sent for pathological autopsy. Read More

J Forensic Sci 2022 Jun 17. Epub 2022 Jun 17.

Department of Legal Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.

Fat embolism syndrome is a life-threatening condition in which fatty substances enter the circulation and cause respiratory distress and neurological symptoms. It can occur following trauma and severe fat embolism occurring soon after trauma is known as fulminant fat embolism syndrome. Although fat staining of the lungs is helpful for diagnosing fat embolism syndrome at autopsy, clinical and other information is needed to determine the relationship between cause of death and the syndrome. Read More

Nat Commun 2022 Jun 20;13(1):3404. Epub 2022 Jun 20.

Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Worldwide, there are nearly 10 million new cases of dementia annually, of which Alzheimer's disease (AD) is the most common. New measures are needed to improve the diagnosis of individuals with cognitive impairment due to various etiologies. Here, we report a deep learning framework that accomplishes multiple diagnostic steps in successive fashion to identify persons with normal cognition (NC), mild cognitive impairment (MCI), AD, and non-AD dementias (nADD). Read More

Ann Diagn Pathol 2022 Aug 30;59:151955. Epub 2022 Apr 30.

Emeritus professor, Department of Pathology, Faculty of Medicine, University of Kocaeli, Izmit, Kocaeli, Turkey; Cytopathology/FNA Private Practice, Izmit, Kocaeli, Turkey.. Electronic address:

Many scientists were forced to leave Germany mostly under challenging circumstances as a result of the pressure applied to anti-Nazi German scientists and artists (mostly from the medical field) who were or were not of Jewish origin before World War II. They emigrated primarily to the United States, Switzerland, Turkey and South America. Two eminent pathology professors, namely Prof. Read More

J Forensic Leg Med 2022 Jun 7;90:102390. Epub 2022 Jun 7.

Department of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Carbon dioxide (CO) is widely used for fire protection and is lethal when inhaled at the minimum design concentration. Two workers were performing periodic maintenance of isolated stored CO cylinders of a fire extinguishing system, and during the maintenance, CO was accidently discharged into the storage room. The workers were found unconscious beside the cylinders and were confirmed dead in the hospital soon after. Read More

Am J Forensic Med Pathol 2022 Jun 14. Epub 2022 Jun 14.

From the Department of Pathology, Western Michigan University Homer Stryker School of Medicine, Kalamazoo, MI.

Abstract: Urushiol, the active antigen in poison ivy (Toxicodendron radicans), is frequently associated with type I and type III hypersensitivity reactions. These reactions most often result in cutaneous symptoms that vary in severity and may at times require medical interventions. Injuries involving other body systems associated with urushiol exposure are far less common. Read More

Am J Forensic Med Pathol 2022 Jun 14. Epub 2022 Jun 14.

From the Laboratorio di Istopatologia Forense e Microbiologia Medico Legale-Sezione di Medicina Legale e delle Assicurazioni-Dipartimento di Scienze Biomediche per la Salute-Università degli Studi di Milano Milano, Italy.

Abstract: Severe fungal infections caused by highly invasive fungi such as Aspergillus are not easy to diagnose and often have a poor prognosis. In these cases, the nonspecific symptoms may make clinical diagnosis challenging, and consequently, the autopsy and postmortem histological investigations acquire a crucial role. We report the case of a young man in good health who died of septic shock 3 weeks after having had a tongue piercing. Read More

Environ Epidemiol 2022 Jun 8;6(3):e213. Epub 2022 Jun 8.

ICMR-National Institute of Epidemiology, Chennai, India.

Background: Chemical leakages cause devastating health effects on humans. On 6 February 2020, seven deaths were reported following a hazardous chemical leakage in a village in Uttar Pradesh, India. We investigated the event to identify the cause and propose recommendations. Read More

Cureus 2022 May 9;14(5):e24850. Epub 2022 May 9.

Internal Medicine, Temple University Hospital, Philadelphia, USA.

Sarcoidosis can be presented as cardiac sarcoidosis (CS), which is challenging to diagnose due to its clinical silence. Ventricular arrhythmias and atrioventricular blocks can be fatal and cause sudden death in patients with cardiac sarcoidosis. Five percent of sarcoidosis patients have clinically evident cardiac sarcoidosis. Read More

Case Rep Gastroenterol 2022 Jan-Apr;16(1):258-263. Epub 2022 Apr 21.

Anatomic Pathology Division, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.

Acute appendicitis (AA) in neonates and infants is an infrequent event. In day-to-day practice, death due to AA is hardly ever reported to a coroner or a medical examiner. Here, we report on an 8-month-old infant assigned to the medical examiner as the death occurred within 10 days of a surgical procedure. Read More

medRxiv 2022 Jun 8. Epub 2022 Jun 8.

Better understanding of the mechanisms of COVID-19 severity is desperately needed in current times. Although hyper-inflammation drives severe COVID-19, precise mechanisms triggering this cascade and what role glycosylation might play therein is unknown. Here we report the first high-throughput glycomic analysis of COVID-19 plasma samples and autopsy tissues. Read More

Int J Clin Exp Pathol 2022 15;15(5):233-237. Epub 2022 May 15.

Department of Hematology, Hikone Municipal Hospital Shiga, Japan.

We report the autopsy findings of a case of disseminated mucormycosis caused by , a rare pathogenic fungus of the family . The patient was a 49-year-old woman with B-lymphoblastic leukemia with hyperdiploidy, who died of progressive heart failure 4 months after induction chemotherapy successfully brought about complete remission of the leukemia. Granulocyte colony-stimulating factor (G-CSF) had been administered along with anti-neoplastic drugs, and her blood neutrophil count was markedly elevated. Read More

JBJS Case Connect 2022 04 8;12(2). Epub 2022 Jun 8.

Department of Spine Surgery, Valdoltra Orthopedic Hospital, Ankaran, Slovenia.

Case: A 68-year-old woman was scheduled to undergo elective correction of coronal spinal malalignment after a previous lumbar instrumented fusion. In the final stages of the operation, the patient became hemodynamically unstable. Her systemic condition worsened subsequently, leading to cardiac arrest followed by unsuccessful resuscitation. Read More

Forensic Sci Med Pathol 2022 Jun 13. Epub 2022 Jun 13.

Department of Public Health and Forensic Sciences, and Medical Education, Faculty of Medicine, University of Porto, 4200-319, Porto, Portugal.

Fatal adverse events caused by any health professional as consequence of malpractice are uncommon. In this work, the authors report a fatal cardiac tamponade associated with a peripherally inserted central catheter (PICC) by the right jugular vein that perforated the right atrium of the heart. The diagnosis of cardiac tamponade was not detected in hospital during the intrapericardial infusion of total parenteral nutrition and was only registered during the autopsy. Read More

Case Rep Gastrointest Med 2022 1;2022:2308065. Epub 2022 Jun 1.

Department of Clinical Pathology, "St. Apostle Andrew" Emergency County Hospital, Constanta, Romania.

Introduction: Multiple primary malignant neoplasms are an uncommon phenomenon, given the very low incidence of two or more different tumors, while neoplasm may be limited to a single organ or may involve multiple separate anatomical organs. The main purpose of this study is to highlight the importance of morphological and immunohistochemical tests to distinguish the origin of the primary tumor. . Read More

Acad Forensic Pathol 2022 Mar 2;12(1):31-38. Epub 2022 Feb 2.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused the COVID-19 pandemic raised important questions about workplace exposures to the virus, including postmortem exposures. The complexity of COVID-19 disease and its numerous unanticipated complications made autopsy even more vital in determining the pathophysiology of the disease. Performing traditional autopsy, however, carries risk of exposure. Read More

Pathology 2022 Jun 9. Epub 2022 Jun 9.

Pathology, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain; Universidad de Alcalá de Henares, Madrid, Spain; CIBERONC, Madrid, Spain. Electronic address:

Severe cases of Coronavirus Disease 2019 (COVID-19) can present with multiple neurological symptoms. The available neuropathological studies have described different lesions; the most frequent was the presence of neuroinflammation and vascular-related lesions. The objective of this study was to report the neuropathological studies performed in a medical institution, with abundant long intensive care unit stays, and their associated clinical manifestations. Read More

J Forensic Sci 2022 Jun 10. Epub 2022 Jun 10.

Department of Legal Medicine, Trauma and Burn Center, Ben Arous, Tunisia.

Cardiac echinococcosis is rare, and its clinical evolution is slow and asymptomatic until complications occur such as sudden death. Although more frequent in endemic countries, hydatid disease should be known by forensic specialists with regard to the migration flows of people from zones with high endemicity and who are likely to die from infection. We report an autopsy case of a 33-year-old male without any medical history who presented to the emergency room with shortness of breath, chest tightness, tingling all over the body and faintness without fever. Read More

Front Neurol 2022 24;13:894565. Epub 2022 May 24.

Office of Chief Medical Examiner, New York, NY, United States.

Two years into the COVID-19 pandemic, there are few published accounts of postmortem SARS-CoV-2 pathology in children. We report 8 such cases (4 infants aged 7-36 weeks, 4 children aged 5-15 years). Four underwent magnetic resonance neuroimaging, to assist in identification of subtle lesions related to vascular compromise. Read More

Am J Forensic Med Pathol 2022 Jun 9. Epub 2022 Jun 9.

Department of Health Care Management and Economics, National Research University Higher School of Economics, Moscow, Russia.

Background: Russia suffers from high alcohol-related mortality. Most forensic autopsies in Russia include blood alcohol tests, but a systematic analysis of these data has never been conducted for children's deaths.

Methods: We performed an analysis of juvenile mortality using autopsy reports from the Moscow Region Bureau of Forensic Medical Examination from January 1, 2009, to December 31, 2018. Read More

Forensic Sci Med Pathol 2022 Jun 7. Epub 2022 Jun 7.

Institute of Legal Medicine, University Hospital Schleswig-Holstein, Kiel/Lübeck, Germany.

Two men were wrongfully convicted of murder in 2017 and sentenced to life imprisonment. After a physical altercation inside a flat, the victim (A) was found dead approximately 60 m away outside a residential address. He had sustained a number of injuries including a stab wound to the left side of his neck which was found to have divided the right carotid artery. Read More

Int Cancer Conf J 2022 Jul 15;11(3):172-177. Epub 2022 Mar 15.

Department of Gastroenterological Surgery, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793 Japan.

Constrictive pericarditis is a rare condition characterized by clinical signs of right heart failure subsequent to the loss of pericardial compliance. We report a case of constrictive pericarditis due to pericardial metastasis in a patient with a history of esophageal squamous cell carcinoma that had a pathological complete response (pCR) to preoperative chemoradiotherapy. A 66-year-old woman was referred to our division for the treatment of advanced esophageal cancer. Read More

J Korean Med Sci 2022 Jun 6;37(22):e183. Epub 2022 Jun 6.

Department of Neurology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) overlap clinically with parkinsonism or extrapyramidal signs and pathologically with tauopathy. Asymmetric parkinsonism and cortical dysfunctions are classical features of CBD. However, symmetric parkinsonism, frequent falls, and supranuclear gaze palsy are key features of PSP. Read More

J Forensic Leg Med 2022 Jun 1;90:102374. Epub 2022 Jun 1.

Department of Forensic Medicine, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, PR China; Chongqing Engineering Research Center for Criminal Investigation Technology, Chongqing, 400016, PR China; Chongqing Key Laboratory of Forensic Medicine, Chongqing, 400016, PR China. Electronic address:

The report is about a 49-year-old man with rheumatic heart disease and atrial fibrillation. He underwent mitral valve replacement, tricuspid valvuloplasty, and atrial fibrillation radiofrequency ablation in the hospital. He vomited blood on the 2nd postoperative day, and the bleeding gradually worsened thereafter. Read More

Leg Med (Tokyo) 2022 May 30;58:102095. Epub 2022 May 30.

Department of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.

MiraDry® is a microwave-based cosmetic device commonly used to treat hyperhidrosis and osmidrosis by affecting apocrine and eccrine sweat glands. In most countries, its application is limited to the axillary region. A healthy woman received MiraDry® treatment in the perineal, genital, and perianal regions for body odor in a cosmetic clinic. Read More