14,541 results match your criteria The Autopsy Report


Fatal Acute Pancreatitis in an Adolescent: A Case Report.

Am J Forensic Med Pathol 2020 Jun 30. Epub 2020 Jun 30.

From the Department of Pathology, University of New Mexico.

Acute pancreatitis is uncommon in children and adolescents, and when it does occur, it is rarely fatal. The cause of death may be misdiagnosed as a death due to diabetic ketoacidosis or an infectious disease if an autopsy is not performed. Because these deaths are often unexpected and may occur before medical care, the forensic pathologist may be contacted to determine the cause of death. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000582DOI Listing

Unexpected and Sudden Death Due to Undiagnosed Moraxella catarrhalis Meningoencephalitis in a 40-day-old Infant: Case Report and Literature Review.

Am J Forensic Med Pathol 2020 Jun 30. Epub 2020 Jun 30.

Sudden Infant Death Syndrome Liguria Centre, Department of Pediatric Emergency, Istituto Giannina Gaslini, Genova, Italy.

Acute bacterial meningitis in infants and newborns represents a medical emergency and a significant cause of mortality and morbidity worldwide. Moraxella catarrhalis has been considered a microorganism with low pathogenic potential, and only in exceptional cases has it been found to cause meningitis in infants and immunocompetent people. We will now document an unusual case of an unexpected and sudden death of a 40-day-old infant due to acute meningitis from M. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000588DOI Listing

Fatal complication of sickle cell anemia in an immigrant patient rescued from the mediterranean sea.

Clin Ter 2020 Jul-Aug;171(4):e291-e294

Department Pro.Mi.Se., University of Palermo.

The aim of this case report is to share with the forensic science community the experience of a rare complication of sickle cell anemia: acute chest syndrome. In October 2016, at the port of the city of Trapani (Sicily, Italy), the landing of an ONG "Médecins Sans Frontières" ship took place with 548 non-EU citizens and a corpse on board. The man, in the hours before his death, complained of severe chest pain and respiratory difficulties, and, despite of the therapeutic aids and resuscitation maneuvers, lastly died. Read More

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http://dx.doi.org/10.7417/CT.2020.2230DOI Listing

SARS-CoV-2-related deaths in routine forensic autopsy practice: histopathological patterns.

Int J Legal Med 2020 Jun 29. Epub 2020 Jun 29.

UOC Medicina Legale ASUR AV3, Via Annibali 31L Piediripa, 62100, Macerata, Italy.

"Severe acute respiratory syndrome" (SARS) due to coronavirus (SARS-CoV-2) infection is a well-known cause of death. Sometimes, demise can occur unexpectedly in apparently previous healthy individual after a brief period of trivial flu-like symptoms. In these doubtful cases, the forensic pathologist could be requested to define the cause of death occurred outside the hospital. Read More

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http://dx.doi.org/10.1007/s00414-020-02354-5DOI Listing

Post-mortem histopathology of a pediatric brain after bilateral DBS of GPI for status dystonicus: case report and review of the literature.

Childs Nerv Syst 2020 Jul 2. Epub 2020 Jul 2.

Pediatric Anesthesiology and Intensive Care Unit, Children's Hospital A. Meyer-University of Florence, Florence, Italy.

Purpose: To investigate the effects of deep brain stimulation (DBS) electrodes on the brain of a dystonic pediatric patient submitted to bilateral DBS of the globus pallidus internus (GPI).

Methods: An 8-year-old male patient underwent bilateral DBS of GPI for status dystonicus. He died 2 months later due to multiorgan failure triggered by bacterial pneumonia. Read More

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http://dx.doi.org/10.1007/s00381-020-04761-wDOI Listing

[Foetus congenital cytomegalovirus infection: report of an autopsy case].

Zhonghua Bing Li Xue Za Zhi 2020 Jul;49(7):748-750

Department of Pathology, Guangdong Second Provincial General Hospital & Guangdong Provincial Emergency Hospital, Guangzhou 510317, China.

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http://dx.doi.org/10.3760/cma.j.cn112151-20200214-00100DOI Listing

Application of scanning electron microscopy in the auxiliary diagnosis of death caused by potassium chloride intravenous injection: a case report.

Int J Legal Med 2020 Jun 30. Epub 2020 Jun 30.

Department of Forensic Medicine, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.

To determine the cause of death, in addition to routine autopsy, some assisted techniques are imperative to achieve a definite diagnosis. Herein, we report a case of 36-year-old man who was found dead in his apartment. Medical drug containers (potassium chloride, zolpidem, and propofol) and medical instruments (syringes and indwelling needles) were also found at the scene. Read More

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http://dx.doi.org/10.1007/s00414-020-02361-6DOI Listing

The adulterated XANAX pill: a fatal intoxication with etizolam and caffeine.

Int J Legal Med 2020 Jun 30. Epub 2020 Jun 30.

Institute of Legal Medicine, University Medical Center, St.-Georg-Strasse 108, 18055, Rostock, Germany.

A 49-year old man was found dead at home next to a glass containing a dried, white, crystalline substance and near a bag containing pills with the imprint XANAX, the trade name of alprazolam. A comprehensive screening of material collected during the autopsy revealed the presence of etizolam and caffeine in lethal concentrations (0.77 μg/mL and 190 μg/mL) but no trace of alprazolam. Read More

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http://dx.doi.org/10.1007/s00414-020-02352-7DOI Listing

COVID-19 autopsy in people who died in community settings: the first series.

J Clin Pathol 2020 Jun 30. Epub 2020 Jun 30.

Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

Here, we report the pathological findings of nine complete autopsies of individuals who died in community settings in the UK, three of which were positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), three tested negative for SARS-CoV-2 but are likely false negatives, and three died of other respiratory infections. Autopsy revealed firm, consolidated lungs or lobar pneumonia. Histology of the lungs showed changes of diffuse alveolar damage with fibrin membrane formation, thickened alveolar walls and interstitium with lymphocytic infiltrate, and type 2 pneumocyte hyperplasia with shedding into the alveolar space. Read More

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http://dx.doi.org/10.1136/jclinpath-2020-206710DOI Listing

Incidental detection of unexpected neck lymphatic III level node metastasis from occult papillary thyroid carcinoma during cervical disc surgery: first literature report.

Endokrynol Pol 2020 Jun 29. Epub 2020 Jun 29.

Pathology Department, District Hospital, Arkonska 4, 71-455 Szczecin, Poland.

Background: The regional lymph node metastases of papillary thyroid carcinoma are very common. Subclinical neck lymphatic malignancy of the undiagnosed papillary carcinoma can be found by chance at autopsy or intravitally, especially during neck imaging scrutiny for other reasons. And cervical lymph node metastasis as the initial manifestation of occult papillary thyroid carcinoma is very rare phenomenon. Read More

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http://dx.doi.org/10.5603/EP.a2020.0031DOI Listing

First Report of spp. Infection in Eurasian Lynx and Its Histopathology Study from Iran: A Case Report.

Iran J Parasitol 2020 Apr-Jun;15(2):282-286

Young Researchers and Elite Club, Babol Branch, Islamic Azad University, Babol, Iran.

According to the last information of IUCN Red List, Eurasian lynx has been endangered since 2010. The population of this animal is heavily affected by infectious parasites. Two adult Eurasian lynx (one male and one female) were illegally hunted and found dead in Parvar National Park, Semnan Province, Iran. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311823PMC

Direct maternal deaths attributable to HIV in the era of antiretroviral therapy: evidence from three population-based HIV cohorts with verbal autopsy.

AIDS 2020 Jul;34(9):1397-1405

Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK.

Objective: To assess whether HIV is associated with an increased risk of mortality from direct maternal complications.

Design: Population-based cohort study using data from three demographic surveillance sites in Eastern and Southern Africa.

Methods: We use verbal autopsy data, with cause of death assigned using the InSilicoVA algorithm, to describe the association between HIV and direct maternal deaths amongst women aged 20-49 years. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002552DOI Listing

Postmortem swabs in the Sars-CoV-2 Pandemic: Report on 12 complete clinical autopsy cases.

Arch Pathol Lab Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Woman and Child Health and Public Health, Area of Pathology, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, U.O.S.D. Coordinamento attività di Settorato; Rome, Italy (Dr. Dell'Aquila, Mr. Stigliano, Dr. Carbone, Dr. Arena); Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Fondazione Policlinico A. Gemelli IRCCS, Catholic University of Sacred Heart, Rome, Italy (Dr. Cattani); Department of laboratory and infectivological sciences, Fondazione Policlinico A. Gemelli IRCCS, Catholic University of Sacred Heart, Rome, Italy (Dr. Fantoni); Department of Safety and Bioethics, Section of Infectious Diseases, Catholic University of Sacred Heart; Columbus Covid 2 Hospital, Fondazione Policlinico A Gemelli IRCCS, Roma, Italy Università Cattolica S. Cuore, (Dr. Marchetti); Institute of Legal Medicine and Department of Surgical and Medical Sciences at the University "Magna Graecia" of Catanzaro, Italy (Dr. Aquila); Department of Safety and Bioethics, Section of Legal Medicine, Fondazione Policlinico A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy (Dr. Oliva).

Clinical autopsies have historically provided a fundamental contribution in the definition of the clinico-pathological basis of infectious diseases. Even though we are witnessing the decline of the clinical autopsy, its importance remains unchanged as it is the most exhaustive way to investigate diseases. The identification of the virus in postmortem tissues is a fundamental step in the definition of its clinical features. Read More

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http://dx.doi.org/10.5858/arpa.2020-0362-SADOI Listing
June 2020
2.838 Impact Factor

Fatal course of clofazimine-induced pulmonary crystal deposition in a patient with Melkersson-Rosenthal syndrome
.

Int J Clin Pharmacol Ther 2020 Jun 26. Epub 2020 Jun 26.

A wide variety of drugs and substances have the potential to damage the respiratory system by different mechanisms. Clofazimine is an anti-leprosy drug that is normally only prescribed for a few years. It has a very long half-life, and crystalline deposition of the drug in various tissues has been documented. Read More

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http://dx.doi.org/10.5414/CP203784DOI Listing

Monochorionic diamniotic twins of discordant external genitalia with 45,X/46,XY mosaicism.

Mol Genet Genomic Med 2020 Jun 25:e1382. Epub 2020 Jun 25.

Center for Maternal-Fetal-Neonatal and Reproductive Medicine, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.

Background: Monozygotic twins with 45,X/46,XY mosaicism, discordant for phenotypic sex, are extremely rare.

Methods: This report describes the clinical findings of a rare case of 45,X/46,XY mosaicism in monozygotic twins with different external genitalia. Single nucleotide polymorphism (SNP) array analysis, performed by collecting DNA from each umbilical cord, showed identical SNPs in the autosomal chromosomes of both fetuses. Read More

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http://dx.doi.org/10.1002/mgg3.1382DOI Listing

An anaplastic pleomorphic xanthoastrocytoma with periventricular extension: An autopsy case report and review of the literature.

Neuropathology 2020 Jun 23. Epub 2020 Jun 23.

Department of Pathology, Shinshu University School of Medicine, Matsumoto, Japan.

Pleomorphic xanthoastrocytomas (PXAs) are rare low-grade astrocytic tumors that typically present as superficial nodular cystic tumors of the cerebrum attached to the leptomeninx. Histologically, they are pleomorphic, hypercellular glial neoplasms. Despite the presence of microscopic pleomorphism, patients' postoperative prognosis is generally good. Read More

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http://dx.doi.org/10.1111/neup.12666DOI Listing

Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients.

EBioMedicine 2020 Jun 20;57:102833. Epub 2020 Jun 20.

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of the Ministry of Education, China. Electronic address:

Background: The novel coronavirus pneumonia COVID-19 caused by SARS-CoV-2 infection could lead to a serious of clinical symptoms and severe illness, including acute respiratory distress syndrome (ARDS) and fatal organ failure. We report the fundamental pathological investigation in the lungs and other organs of fatal cases for the mechanistic understanding of severe COVID-19 and the development of specific therapy in these cases.

Methods: The autopsy and pathological investigations of specimens were performed on bodies of two deceased cases with COVID-19. Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305897PMC

Pontocerebellar Hypoplasia Diagnosed on Autopsy: A Case Report.

Cureus 2020 May 18;12(5):e8178. Epub 2020 May 18.

General and Clinical Pathology/Forensic Medicine and Deontology, Medical University of Varna, Varna, BGR.

Pontocerebellar hypoplasia (PCH) is a diverse group of autosomal recessive genetic conditions presenting with hypoplastic changes in the brainstem, cerebellum, and spinal cord. It clinically manifests with neurological symptoms, respiratory failure, and often in a combination with other malformations of the internal organs and musculoskeletal system. In this report, we present an autopsy case report of a two-month-old female patient with blood-relative parents. Read More

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http://dx.doi.org/10.7759/cureus.8178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301432PMC

Assessment of candidate variants causative of inborn metabolic diseases in SUDI cases in South Africa, and a case report.

Int J Legal Med 2020 Jun 18. Epub 2020 Jun 18.

MRC/UCT Research Unit for Genomic and Precision Medicine, Division of Human Genetics, Institute of Infectious Diseases and Molecular Medicine, Department of Pathology, University of Cape Town, Cape Town, South Africa.

Sudden unexpected death in infants (SUDI) is a devastating event, and unfortunately is still a burden in many parts of the world, including in South Africa. Due to the absence of routine testing for inborn metabolic diseases in newborns and in a post-mortem context, little is known about the presence of metabolic diseases in local SUDI cases. The aim of this study was to genotype five candidate variants previously associated with metabolic disorders in a cohort of SUDI cases (n = 169) from Salt River Mortuary, Cape Town. Read More

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http://dx.doi.org/10.1007/s00414-020-02337-6DOI Listing

Autopsy evaluation of the implantation site of a His bundle pacing lead demonstrating selective capture.

Pacing Clin Electrophysiol 2020 Jun 16. Epub 2020 Jun 16.

Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Evaluations of His bundle pacing (HBP) lead location at autopsy examination have been rarely reported. We report an autopsy case of a 98-year-old man who underwent HBP implantation due to atrioventricular block and heart failure. Although selective HBP was achieved with an acceptable threshold, the stimulus-to-QRS interval was relatively longer without correction of the right bundle-branch block. Read More

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http://dx.doi.org/10.1111/pace.13989DOI Listing

Intravascular Lymphoma with Progressive CNS Hemorrhage and Multiple Dissections.

Case Rep Neurol Med 2020 10;2020:6134830. Epub 2020 Jan 10.

Department of Neurology, University of Utah, 175 N Medical Dr., Salt Lake City, UT 84132, USA.

Introduction: Intravascular lymphoma (IVL) is an uncommon and often fatal disease characterized by intraluminal proliferation of lymphomatous cells within blood vessels. Because of a heterogeneous clinical presentation and lack of sensitive diagnostic protocols, diagnosis of IVL is most often made at autopsy. However, with early diagnosis and appropriate chemotherapy, the prognosis is greatly improved and complete remission is possible. Read More

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http://dx.doi.org/10.1155/2020/6134830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201472PMC
January 2020

Sudden cardiac death due to ventricular fibrillation in a case of giant cell myocarditis.

J Cardiol Cases 2020 Jun 12;21(6):224-226. Epub 2020 Mar 12.

Department of Cardiology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.

A 70-year-old woman was admitted to our hospital complaining of shortness of breath. She was diagnosed with acute decompensated heart failure due to left ventricular dysfunction. Her symptoms began to improve with standard therapy for heart failure with diuretics, noninvasive pressure ventilation, and inotropes, but paroxysmal atrial fibrillation and premature ventricular contractions (PVCs) occurred. Read More

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http://dx.doi.org/10.1016/j.jccase.2020.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283290PMC

Surgical and endoscopic management of a pericardioesophageal fistula after radiofrequency pulmonary vein isolation.

Pacing Clin Electrophysiol 2020 Jun 16. Epub 2020 Jun 16.

Division of Cardiology, Department of Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.

Introduction: The most feared complication of pulmonary vein isolation (PVI) is an atrioesophageal fistula (AEF). While rare (0.1-0. Read More

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http://dx.doi.org/10.1111/pace.13988DOI Listing

Acute Necrotizing Encephalitis in Viral Respiratory Tract Infection: An Autopsy Case Report.

Cureus 2020 May 12;12(5):e8070. Epub 2020 May 12.

General and Clinical Pathology/Forensic Medicine and Deontology, Medical University of Varna, Varna, BGR.

Acute necrotizing encephalitis (ANE) is a rare complication of viral respiratory tract infections, with specific histological changes. The condition is most commonly described in the pediatric population, however, it can also develop in the elderly, with some genetic factors being described as contributory. Herein, we report the autopsy finding of a patient with a viral respiratory tract infection, complicated with ANE. Read More

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http://dx.doi.org/10.7759/cureus.8070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290120PMC

Post-thyroidectomy tracheocutaneous fistula; A case report with literature review.

Int J Surg Case Rep 2020 May 30;72:172-174. Epub 2020 May 30.

Kscien Organization for Scientific Research, Hamdi Street, Sulaimani, Kurdistan, Iraq.

Introduction: Total thyroidectomy represents one of the commonest procedures performed for thyroid diseases. The aim of this paper is to report a rare case of tracheocutaneous fistula after total thyroidectomy.

Case Report: A 44-year-age female presented with left side neck swelling for 2 month duration. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299899PMC

Domestic homicide in Maputo Province, Mozambique.

Forensic Sci Int 2020 10;2:157-161. Epub 2020 Apr 10.

Statistics Department, Maputo Central Hospital, Mozambique.

Background: Domestic Homicide is the most extreme form of domestic violence reported worldwide. Although in Mozambique there are public reports of domestic homicide, no research has been published that describes its pattern.

Aim: This study aims to describe the pattern of domestic homicides in Maputo Province, Mozambique. Read More

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http://dx.doi.org/10.1016/j.fsisyn.2020.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269967PMC

The Fatal Case of an Autochthonous Heartworm Disease in a Dog from a Non-endemic Region of South-eastern Slovakia.

Helminthologia 2020 Jun 23;57(2):154-157. Epub 2020 May 23.

Department of Epizootology and Parasitology, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 040 01 Košice, Slovakia.

During the past few years, several localities with increasing occurrences have been identified in Slovakia; particularly in areas regarded as endemic for up until now. In terms of that, dogs with clinically manifested heartworm disease have been referred to the veterinary ambulances more frequently. We report in this study, two autochthonous cases of infections diagnosed in two seven-year-old siblings of Tibetan Mastiff dogs from the Košice region of south-eastern Slovakia. Read More

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http://dx.doi.org/10.2478/helm-2020-0023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261026PMC

Cancer of Unknown Primary (CUP): genetic evidence for a novel nosological entity? A case report.

EMBO Mol Med 2020 Jun 8:e11756. Epub 2020 Jun 8.

Molecular Therapeutics and Exploratory Research Laboratory, Candiolo Cancer Institute, FPO - IRCCS, Candiolo (Turin), Italy.

Cancer of unknown primary (CUP) is an obscure disease characterized by multiple metastases in the absence of a primary tumor. No consensus has been reached whether CUPs are simply generated from cancers that cannot be detected or whether they are the manifestation of a still unknown nosological entity. Here, we report the complete expression and genetic analysis of multiple synchronous metastases harvested at warm autopsy of a patient with CUP. Read More

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http://dx.doi.org/10.15252/emmm.201911756DOI Listing

Erythrocytes Reveal Complement Activation in Patients with COVID-19.

medRxiv 2020 May 22. Epub 2020 May 22.

COVID-19, the disease caused by the SARS-CoV-2 virus, can progress to multi-organ failure characterized by respiratory insufficiency, arrhythmias, thromboembolic complications and shock. The mortality of patients hospitalized with COVID-19 is unacceptably high and new strategies are urgently needed to rapidly identify and treat patients at risk for organ failure. Clinical epidemiologic studies demonstrate that vulnerability to organ failure is greatest after viral clearance from the upper airway, which suggests that dysregulation of the host immune response is a critical mediator of clinical deterioration and death. Read More

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http://dx.doi.org/10.1101/2020.05.20.20104398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274235PMC

Sudden death due to ruptured oesophageal varices - autopsy-based case report.

Med Leg J 2020 Jun 5:25817220926929. Epub 2020 Jun 5.

Department of Forensic Medicine, University College of Medical Sciences & GTB Hospital, Delhi, India.

Acute haemorrhage from ruptured oesophageal varices is a serious consequence of portal hypertension in cirrhotic patients. It represents a medical emergency with a high morbidity and mortality rate. Studies over the years have shown a direct link with chronic alcoholism in the development of such complications. Read More

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http://dx.doi.org/10.1177/0025817220926929DOI Listing

The Diagnosis of a Case of Household Cleaner Fatality.

Am J Forensic Med Pathol 2020 Jun 3. Epub 2020 Jun 3.

Forensic Sciences Department, Chennai, India.

Household cleaners are an unavoidable entity in our routine domestic life. They are available either in company-labeled bottles or locally made unlabeled bottles especially in the developing countries. In this report, we are discussing a case of fatal ingestion of household cleaner, which was stored in an unlabeled bottle. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000566DOI Listing
June 2020
0.624 Impact Factor

Signet Ring Cell Differentiation in Salivary Duct Carcinoma with Rhabdoid Features: Report of Three Cases and Literature Review.

Head Neck Pathol 2020 Jun 2. Epub 2020 Jun 2.

Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

Salivary duct carcinoma with rhabdoid features (SDCRF) is a rare salivary tumor with poor prognosis and is proposed as a salivary counterpart of pleomorphic lobular carcinoma of the breast (PLCB). Here, we report three cases of SDC with rhabdoid features (SDCRF) mimicking PLCB. Pleomorphic adenoma (PA) component was accompanied in all the cases confirming carcinoma ex PA. Read More

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http://dx.doi.org/10.1007/s12105-020-01186-4DOI Listing

Intravascular carcinomatosis of the brain: a report of two cases.

Brain Tumor Pathol 2020 Jul 1;37(3):118-125. Epub 2020 Jun 1.

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada.

Although central nervous system (CNS) metastases are common in advanced cancer, CNS involvement solely by intravascular tumor cells, known as intravascular carcinomatosis, is extremely rare. We report two cases of brain metastasis in which tumor cells were restricted to the vascular lumina without parenchymal involvement, resulting in ischemic lesions. The first patient is a previously healthy young woman who presented with symptoms of community-acquired pneumonia and progressed to respiratory failure. Read More

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http://dx.doi.org/10.1007/s10014-020-00367-xDOI Listing

[Pathological changes of fatal coronavirus disease 2019 (COVID-19) in the lungs: report of 10 cases by postmortem needle autopsy].

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):568-575

Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

To observe the pulmonary changes with coronavirus disease 2019 (COVID-19) in postmortem needle specimens, to detect the presence of 2019 novel coronavirus(2019-nCoV) in the lung tissues, and to analyze the clinicopathological characteristics. For 10 decedents with 2019-nCoV infection in Wuhan, bilateral lungs underwent ultrasound-guided percutaneous multi-point puncture autopsy, and pulmonary pathological changes were described in routine hematoxylin-eosin staining (HE) slides. Electron microscopy was also performed. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20200405-00291DOI Listing

Spontaneously ruptured hepatocellular carcinoma in Fontan-associated liver disease: A case report.

SAGE Open Med Case Rep 2020 6;8:2050313X20922030. Epub 2020 May 6.

Division of Gastroenterology, Third Department of Internal Medicine, Nara Medical University, Nara, Japan.

The prognosis of congenital heart disease is dramatically improved by cardiac surgery. The Fontan procedure is the definitive palliative operation for patients with single-ventricle physiology. In parallel with the longer survival time achieved with the Fontan procedure, the incidence of Fontan-associated liver disease is increasing. Read More

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http://dx.doi.org/10.1177/2050313X20922030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234346PMC

Post-mortem CT with macroscopic and microscopic correlation in a case of sudden death due to systemic sarcoidosis.

Forensic Sci Med Pathol 2020 May 31. Epub 2020 May 31.

Department of Pathobiology and Laboratory Medicine, University of Toronto & Ontario Forensic Pathology Service, Toronto, Ontario, Canada.

We report a case of sudden death due to systemic sarcoidosis in a fifty-four year old male who was reportedly healthy. A computerized tomography (CT) scan was performed before the autopsy. It showed cardiomegaly with hilar and abdominal lymphadenopathy. Read More

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http://dx.doi.org/10.1007/s12024-020-00259-8DOI Listing

Idiopathic myenteric ganglionitis as a cause of death in a young male patient with sudden abdominal pain: an autopsy case report.

Int J Colorectal Dis 2020 May 30. Epub 2020 May 30.

Division of Human Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan.

Background: Myenteric ganglionitis is a disorder that causes intestinal motor dysfunction. It may be caused due to neoplastic, central nervous system, or systemic infectious disorders. However, some cases are considered to be idiopathic in origin. Read More

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http://dx.doi.org/10.1007/s00384-020-03631-wDOI Listing

Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans.

Lancet Respir Med 2020 May 27. Epub 2020 May 27.

Department of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA, USA. Electronic address:

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly across the USA, causing extensive morbidity and mortality, particularly in the African American community. Autopsy can considerably contribute to our understanding of many disease processes and could provide crucial information to guide management of patients with coronavirus disease 2019 (COVID-19). We report on the relevant cardiopulmonary findings in, to our knowledge, the first autopsy series of ten African American decedents, with the cause of death attributed to COVID-19. Read More

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http://dx.doi.org/10.1016/S2213-2600(20)30243-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255143PMC

Malignant adenomyoepithelioma of the breast.

Surg Case Rep 2020 May 29;6(1):118. Epub 2020 May 29.

Department of Breast Surgery, Niigata City General Hospital, 463-7 Shumoku, Chuo-ku, Niigata, 950-1197, Japan.

Background: Adenomyoepithelioma (AME) of the breast is a very rare tumor and is generally considered to be benign. However, some show malignant transformation, which results in local recurrences or distant metastases. The morphological features of AME that might predict malignant potential have not been elucidated. Read More

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http://dx.doi.org/10.1186/s40792-020-00881-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260303PMC

Detection of SARS-CoV-2 in Human Retinal Biopsies of Deceased COVID-19 Patients.

Ocul Immunol Inflamm 2020 May 29:1-5. Epub 2020 May 29.

Department of Ophthalmology, University Medical Center Hamburg-Eppendorf (UKE) , Hamburg, Germany.

Purpose: To report the presence of viral ribonucleic acid (RNA) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human retina in deceased patients with confirmed novel coronavirus disease 2019 (COVID-19).

Patients And Methods: Fourteen eyes of 14 deceased patients with confirmed COVID-19 disease were enucleated during autopsy. A sample of human retina was secured and fixed in RNAlater™. Read More

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http://dx.doi.org/10.1080/09273948.2020.1770301DOI Listing

Clinical and Imaging Markers of Prodromal Parkinson's Disease.

Front Neurol 2020 8;11:395. Epub 2020 May 8.

Department of Neurology, St. Olavs Hospital, Trondheim, Norway.

The diagnosis of Parkinson's disease (PD) relies on the clinical effects of dopamine deficiency, including bradykinesia, rigidity and tremor, usually manifesting asymmetrically. Misdiagnosis is common, due to overlap of symptoms with other neurodegenerative disorders such as multiple system atrophy and progressive supranuclear palsy, and only autopsy can definitively confirm the disease. Motor deficits generally appear when 50-60% of dopaminergic neurons in the substantia nigra are already lost, limiting the effectiveness of potential neuroprotective therapies. Read More

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http://dx.doi.org/10.3389/fneur.2020.00395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225301PMC

Hepatitis C virus relapse after successful treatment with direct-acting antivirals, followed by sarcomatous changes in hepatocellular carcinoma: a case report.

J Med Case Rep 2020 May 27;14(1):62. Epub 2020 May 27.

Department of Gastroenterology, Mitsui Memorial Hospital, 1 Kandaizumi-cho Chiyoda-ku, Tokyo, 101-8643, Japan.

Background: Combination therapy of interferon and ribavirin has traditionally been used to eradicate hepatitis C virus. The sustained virologic response achieved with interferon-related therapy is persistent, and late relapses after achieving sustained virologic response at 24 weeks using this therapy are reportedly rare (< 1%). In 2014, interferon-free therapy with direct-acting antivirals was developed, and the rate of sustained virologic response was improved. Read More

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http://dx.doi.org/10.1186/s13256-020-02392-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251811PMC

Mystery of a Family with Recurrent Male Infant Deaths- Solved by Autopsy and Molecular Tests.

Indian J Pediatr 2020 May 26. Epub 2020 May 26.

Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

The authors report a case of a six weeks old boy who presented with acute febrile illness and progressive abdominal distension. There was a significant family history of early male sibling deaths. Autopsy showed multiorgan abscesses. Read More

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http://dx.doi.org/10.1007/s12098-020-03304-0DOI Listing
May 2020
0.919 Impact Factor

Sudden Cardiac Arrest in an Asymptomatic Zinc Phosphide-Poisoned Patient: A Case Report.

Cardiovasc Toxicol 2020 May 25. Epub 2020 May 25.

Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Zinc phosphide is a gray to black powder mainly used as a rodenticide. In contact with gastric fluid, it releases phosphine which is the main toxic material of this compound. Phosphine interferes with oxidative respiratory cycle of the cells, but is generally expected to manifest its toxicity with prodromal signs and symptoms including abdominal pain, nausea and vomiting, metabolic acidosis, and increased liver function tests. Read More

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http://dx.doi.org/10.1007/s12012-020-09578-2DOI Listing

Molecular Detection of SARS-CoV-2 Infection in FFPE Samples and Histopathologic Findings in Fatal SARS-CoV-2 Cases.

Am J Clin Pathol 2020 May 26. Epub 2020 May 26.

Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH.

Objectives: To report methods and findings of 2 autopsies with molecular evaluation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive individuals.

Methods: Postmortem examination was completed following Centers for Disease Control and Prevention public guidelines. Numerous formalin-fixed paraffin-embedded (FFPE) tissue types from each case were surveyed for SARS-CoV-2 RNA by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Read More

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http://dx.doi.org/10.1093/ajcp/aqaa091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314275PMC

Neuropathology of COVID-19: a spectrum of vascular and acute disseminated encephalomyelitis (ADEM)-like pathology.

Acta Neuropathol 2020 07 24;140(1):1-6. Epub 2020 May 24.

Department of Neurology, Mayo Clinic, Rochester, MN, USA.

We report the neuropathological findings of a patient who died from complications of COVID-19. The decedent was initially hospitalized for surgical management of underlying coronary artery disease. He developed post-operative complications and was evaluated with chest imaging studies. Read More

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http://dx.doi.org/10.1007/s00401-020-02166-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245994PMC