7,578 results match your criteria The American journal of surgical pathology[Journal]


SOX11-negative Mantle Cell Lymphoma: Clinicopathologic and Prognostic Features of 75 Patients.

Am J Surg Pathol 2019 Feb 12. Epub 2019 Feb 12.

Departments of Hematopathology.

Studies have suggested that SOX11 expression has prognostic implications in patients with mantle cell lymphoma (MCL), but the data are controversial. In this study, we describe the clinicopathologic and prognostic features of 75 patients with SOX11-negative MCL. Compared with patients with SOX11-positive MCL, SOX11-negative MCL patients more frequently had leukemic non-nodal disease (21% vs. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001233DOI Listing
February 2019

George M. Farrow, MD: A Tribute.

Am J Surg Pathol 2019 Mar;43(3):432-433

Division of Anatomic Pathology, Rochester, MN.

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http://dx.doi.org/10.1097/PAS.0000000000000942DOI Listing

Prospective Detection of Germline Mutation of Fumarate Hydratase in Women With Uterine Smooth Muscle Tumors Using Pathology-based Screening to Trigger Genetic Counseling for Hereditary Leiomyomatosis Renal Cell Carcinoma Syndrome: A 5-Year Single Institutional Experience.

Am J Surg Pathol 2019 Feb 6. Epub 2019 Feb 6.

Pathology Department, University of California San Francisco.

Pathology-based screening of uterine smooth muscle tumors (uSMT) for morphology suggestive of fumarate hydratase deficiency (FH-d morphology) has been proposed as a method to identify women at increased risk for hereditary leiomyomatosis renal cell carcinoma (HLRCC) syndrome. For 5 years our clinical diagnostic practice has evaluated all women with any type of uSMT for FH-d morphology (defined, at low magnification, as staghorn shaped blood vessels and alveolar pattern edema and, at high magnification, as tumor macronucleoli surrounded by a halo and cytoplasmic eosinophilic globules) and, when present, used the pathology report to advise genetic counseling to further evaluate for HLRCC syndrome. We now report the results of this prospective screening strategy, with emphasis on the incidence and clinicopathologic features of FH-d morphology in uSMT, the rate of patient uptake of referral to genetic counseling, and the results of genetic testing for FH germline mutation. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001222DOI Listing
February 2019
1 Read

90Y-TheraSpheres: The New Look of Yttrium-90.

Am J Surg Pathol 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD.

Selective internal radiation therapy with Y-TheraSphere or Y-SIRSphere is used in the treatment of unresectable hepatic malignancies. To the best of our knowledge, this is the first Y-TheraSpheres series. BTG International Canada Inc. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001223DOI Listing
February 2019

Expanding the Spectrum of Intraosseous Rhabdomyosarcoma: Correlation Between 2 Distinct Gene Fusions and Phenotype.

Am J Surg Pathol 2019 Feb 1. Epub 2019 Feb 1.

Departments of Pathology.

Primary intraosseous rhabdomyosarcomas (RMSs) are extremely rare. Recently 2 studies reported 4 cases of primary intraosseous RMS with EWSR1/FUS-TFCP2 gene fusions, associated with somewhat conflicting histologic features, ranging from spindle to epithelioid. In this study we sought to further investigate the pathologic and molecular abnormalities of a larger group of intraosseous RMSs by a combined approach using targeted RNA sequencing analysis and fluorescence in situ hybridization (FISH). Read More

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http://dx.doi.org/10.1097/PAS.0000000000001227DOI Listing
February 2019
1 Read

Clinical Outcomes of HPV-associated and Unassociated Endocervical Adenocarcinomas Categorized by the International Endocervical Adenocarcinoma Criteria and Classification (IECC).

Am J Surg Pathol 2019 Feb 1. Epub 2019 Feb 1.

Departments of Pathology.

The International Endocervical Adenocarcinoma Criteria and Classification (IECC) categorizes endocervical adenocarcinomas (ECAs) on the basis of morphologic features linked to etiology (ie, human papilloma virus [HPV] infection), resulting in separation of ECAs into HPV-associated (HPVA) and unassociated or non-HPVA (NHPVA) types. NHPVAs are reported to be large and present at high stage in older individuals. Our aim was to examine the clinical outcomes in these tumor types. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001224DOI Listing
February 2019
1 Read

Impact of Peritoneal Metastasis on Survival of Patients With Small Intestinal Neuroendocrine Tumor.

Am J Surg Pathol 2019 Jan 29. Epub 2019 Jan 29.

Departments of Pathology, Microbiology, and Immunology.

The liver and peritoneum are the 2 most common distant metastatic sites for small intestinal neuroendocrine tumors (SI-NET). In this study, we evaluated the differential impact of hepatic and/or peritoneal metastasis on prognosis of SI-NET patients. Surgical Pathology archives were searched for SI-NET resections performed between January 1, 1994 and August 31, 2017. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001225DOI Listing
January 2019

Adenocarcinoma of the Rete Testis: Clinicopathologic and Immunohistochemical Characterization of 6 Cases and Review of the Literature.

Am J Surg Pathol 2019 Jan 22. Epub 2019 Jan 22.

Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.

Adenocarcinoma of the rete testis is rare and its etiological and pathologic characteristics are not well studied. We therefore investigated the clinical, morphologic, and immunohistochemical features of 6 cases diagnosed at our institution and conducted a detailed review of the literature. The mean age was 64 years. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001219DOI Listing
January 2019
6 Reads

Intrasinusoidal Spread of Hepatic Epithelioid Hemangioendothelioma: Implications for the Diagnosis in Minimal Samples.

Am J Surg Pathol 2019 Jan 16. Epub 2019 Jan 16.

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY.

Epithelioid hemangioendothelioma (EHE) is an angiocentric tumor that, when arising in liver, is centered around hepatic/portal veins. However, EHE cells can also track along sinusoids, which is not well recognized or studied. We identified 18 cases of hepatic EHE and 6 nonhepatic EHEs. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001221DOI Listing
January 2019
1 Read

Activating Structural Alterations In MAPK Genes Are Distinct Genetic Drivers In a Unique Subgroup Of Spitzoid Neoplasms.

Am J Surg Pathol 2019 Jan 11. Epub 2019 Jan 11.

Departments of Dermatology.

Recent studies have described kinase fusions as the most common initiating genomic events in Spitzoid neoplasms. Each rearrangement generates a chimeric protein with constitutive activation of the tyrosine kinase domain, resulting in the development of a Spitzoid neoplasm. Identifying key initiating genomic events and drivers may assist in diagnosis, prognostication, and management. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001213DOI Listing
January 2019
6 Reads

SOX10, GATA3, GCDFP15, Androgen Receptor, and Mammaglobin for the Differential Diagnosis Between Triple-negative Breast Cancer and TTF1-negative Lung Adenocarcinoma.

Am J Surg Pathol 2019 Mar;43(3):293-302

Departments of Biopathology.

Triple-negative breast cancer (TNBC) patients have an increased risk of developing visceral metastases and other primary nonbreast cancers, particularly lung cancer. The differential diagnosis of TNBC metastases and primary cancers from other organs can be difficult due to lack of a TNBC standard immunoprofile. We analyzed the diagnostic value of estrogen receptor, progesterone receptor, human epidermal growth factor receptor, thyroid transcription factor-1 (TTF1), Napsin A, mammaglobin, gross cystic disease fluid protein 15 (GCDFP15), Sry-related HMg-Box gene 10 (SOX10), GATA-binding protein 3 (GATA3), and androgen receptor in a series of 207 TNBC and 152 primary lung adenocarcinomas (LA). Read More

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http://dx.doi.org/10.1097/PAS.0000000000001216DOI Listing
March 2019
1 Read

Histologic Response to Neoadjuvant Therapy is Not Predictive of Favorable Outcomes in High-grade Pleomorphic Soft Tissue Sarcoma.

Authors:
Justin M M Cates

Am J Surg Pathol 2019 Jan 8. Epub 2019 Jan 8.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN.

The College of American Pathologists recommends reporting the histologic response of soft tissue sarcomas (STS) to neoadjuvant therapy, presumably as an assessment of chemosensitivity and a prognostic indicator, despite lack of evidence of clinical utility as such. This study examines whether extent of neoadjuvant therapy effect in STS is a favorable prognostic factor for disease-free survival. Extent of tumor necrosis and stromal hyalinization/fibrosis were determined in 143 high-grade, nonmetastatic, pleomorphic STS of the extremity or trunk. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001214DOI Listing
January 2019
1 Read

Napsin A, Hepatocyte Nuclear Factor-1-Beta (HNF-1β), Estrogen and Progesterone Receptors Expression in Arias-Stella Reaction.

Am J Surg Pathol 2019 Mar;43(3):325-333

Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China.

Background: The Arias-Stella reaction (ASR) can mimic endometrial clear cell carcinoma (ECCC) in small biopsies, especially when drug or pregnancy history is unknown. A panel of immunohistochemical markers comprising napsin A, hepatocyte nuclear factor-1-beta (HNF-1β), estrogen and progesterone receptors (ER, PR) has been found useful in confirming a diagnosis of ECCC. However, the detailed characterization of how expression of this combination of markers in the ECCC mimics ASR has yet to be thoroughly evaluated. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001212DOI Listing
March 2019
3 Reads

De Novo Testicular Extranodal NK/T-Cell Lymphoma: A Clinicopathologic Study of 21 Cases With Review of Additional 18 Cases in the Literature.

Am J Surg Pathol 2018 Dec 26. Epub 2018 Dec 26.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine.

Although the testis is not uncommonly involved during the course of disease in both nasal and non-nasal extranodal NK/T-cell lymphoma (ENKTCL), only a few cases presenting initially with a testicular mass have been previously reported. These have been documented as case reports, rather than as study series. Because of its rarity, the clinicopathologic features and the prognosis of de novo testicular ENKTCL have not been well characterized. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001210DOI Listing
December 2018
2 Reads

Targeted Molecular and Immunohistochemical Analyses of Endometrial Clear Cell Carcinoma Show that POLE Mutations and DNA Mismatch Repair Protein Deficiencies are Uncommon.

Am J Surg Pathol 2018 Dec 24. Epub 2018 Dec 24.

Department of Laboratory Medicine and Pathology, University of Saskatchewan, Saskatoon, SK.

Endometrial clear cell carcinoma (ECCC) is an uncommon histotype without unique identified molecular alterations. Recently, The Cancer Genome Atlas molecular subtypes have been reported in ECCC. ECCC cases were collected from 11 institutions with diagnoses confirmed by morphologic review and immunohistochemistry. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001209DOI Listing
December 2018
6 Reads

SSTR2a Is a Useful Diagnostic Marker for Follicular Dendritic Cells and Their Related Tumors.

Am J Surg Pathol 2019 Mar;43(3):374-381

Department of Pathology, Peking University Shenzhen Hospital, Shenzhen.

SSTR2a, a member of the somatostatin receptor family, has been used as a diagnostic marker of meningioma. However, the expression of SSTR2a in follicular dendritic cells (FDCs) and their related tumors has been poorly characterized. This study aimed to assess the potential diagnostic utility of measuring SSTR2a immunohistochemically in FDCs and their related tumors. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001205DOI Listing
March 2019
3 Reads

Expanding the Spectrum of Pediatric NTRK-rearranged Mesenchymal Tumors.

Am J Surg Pathol 2018 Dec 24. Epub 2018 Dec 24.

Department of Laboratories, Seattle Children's Hospital, Seattle, WA.

Pediatric mesenchymal tumors harboring variant NTRK fusions (ETV6-negative) are being increasingly described; however, the histologic and clinical features of these variant NTRK tumors and their relationship to classic infantile fibrosarcoma are not well characterized. A better understanding of the clinicopathologic features of these tumors is necessary, and would aid in both early diagnosis and treatment. Therefore, the aim of this study was to characterize a series of pediatric NTRK-rearranged mesenchymal tumors, including classic ETV6-NTRK3 fused tumors and tumors with variant (non-ETV6) NTRK fusions. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001203DOI Listing
December 2018
2 Reads

PRDM10-rearranged Soft Tissue Tumor: A Clinicopathologic Study of 9 Cases.

Am J Surg Pathol 2018 Dec 18. Epub 2018 Dec 18.

Department of Clinical Genetics and Pathology, University and Regional Laboratories, Skåne University Hospital, Lund University.

Gene fusion transcripts containing PRDM10 were recently identified in low-grade undifferentiated pleomorphic sarcomas (UPS). Here, we describe the morphologic and clinical features of 9 such tumors from 5 men and 4 women (age: 20 to 61 y). Three cases had previously been diagnosed as UPS, 3 as superficial CD34-positive fibroblastic tumor (SCD34FT), 2 as pleomorphic liposarcoma, and 1 as pleomorphic hyalinizing angiectatic tumor. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001207DOI Listing
December 2018
12 Reads

A Comprehensive Analysis of the Association Between Gleason Score at a Positive Surgical Margin and the Risk of Biochemical Recurrence After Radical Prostatectomy.

Am J Surg Pathol 2019 Mar;43(3):369-373

Departments of Urology.

Our objective was to identify the best of the existing definitions of Gleason score (GS) at a positive surgical margin (PSM) by validating them in our radical prostatectomy cohort. We analyzed 251 patients who had mixed (3+4, 3+5, 4+3 or 5+3) pathologic GS and PSM. We used 5 definitions to record GS at a PSM. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001204DOI Listing
March 2019
7 Reads

Clinicopathologic and Molecular Features of Metastatic Follicular Thyroid Carcinoma in Patients Presenting With a Thyroid Nodule Versus a Distant Metastasis.

Am J Surg Pathol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, University of Chicago Medical Center.

Metastatic follicular thyroid carcinoma (FTC) is rare. The aim of this study was to determine the clinical, histologic, and molecular differences between patients with metastatic FTC who present with distant metastatic (DM) disease versus those who present with a primary thyroid nodule (PT). Clinical and pathologic information was extracted from the medical record and surgical pathology report. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001208DOI Listing
December 2018
3 Reads

Neuroglial Differentiation and Neoplasms in Testicular Germ Cell Tumors Lack Immunohistochemical Evidence of Alterations Characteristic of Their CNS Counterparts: A Study of 13 Cases.

Am J Surg Pathol 2019 Mar;43(3):422-431

Departments of Pathology.

Overgrowth of neuroglial tissue is rare in testicular germ cell tumors and mostly reported as isolated cases. We retrospectively reviewed 13 cases of testicular germ cell tumors from 2 institutions from 1995 to 2018. Hematoxylin and eosin slides were collected and reviewed. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001206DOI Listing
March 2019
3 Reads

Gray-zone Lymphoma Between cHL and Large B-Cell Lymphoma: A Histopathologic Series From the LYSA.

Am J Surg Pathol 2019 Mar;43(3):341-351

INSERM1052, CNRS 5286, Lyon-Sud Charles Mérieux Lyon-1 Faculty, Claude Bernard University.

Gray-zone lymphoma (GZL) with features intermediate between classic Hodgkin lymphoma (cHL) and large B-cell lymphoma (LBCL) was introduced as a provisional entity into the World Health Organization classification in 2008. However, as diagnostic criteria are imprecise, reliable identification of GZL cases remains challenging. Here, we describe the histopathologic features of 139 GZL cases from a retrospective Lymphoma Study Association (LYSA) study with the goal to improve classification accuracy. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001198DOI Listing
March 2019
12 Reads

Histopathologic False-positive Diagnoses of Prostate Cancer in the Age of Immunohistochemistry.

Am J Surg Pathol 2019 Mar;43(3):361-368

Department of Cellular Pathology, Barts Health NHS Trust.

There are few studies into the rate and causes of histopathologic false-positive diagnosis of prostate cancer. Only 2 of these, including a previous one from our group, incorporate survival data. In addition, in none of the previous studies had immunohistochemistry (IHC) been originally requested on any of the misdiagnosed cases. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375390PMC
March 2019
1 Read

Cholangiolocellular Carcinoma With "Ductal Plate Malformation" Pattern May Be Characterized by ARID1A Genetic Alterations.

Am J Surg Pathol 2019 Mar;43(3):352-360

Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa.

Cholangiolocellular carcinoma (CLC) is a unique subtype of primary liver carcinoma, which sometimes coexists with hepatocellular carcinoma (HCC), cholangiocarcinoma and combined hepatocellular-cholangiocarcinoma (cHCC-CCA). "Ductal plate malformation" (DPM)-pattern of primary liver carcinoma, which resembles biliary lesions in Caroli disease and von Meyenburg complex, is sometimes associated with CLC. We examined genetic alterations of hTERT promoter (hTERT), IDH1 or 2 (IDH1/2), KRAS, ARID1A, PBRM1, ARID2, BAP1, p53 and their association with histologic features such as proportion of CLC and DPM-pattern in 77 patients with primary liver carcinoma diagnosed as cHCC-CCA or CLC. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001201DOI Listing
March 2019
12 Reads

MDM2 RNA In Situ Hybridization for the Diagnosis of Atypical Lipomatous Tumor: A Study Evaluating DNA, RNA, and Protein Expression.

Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.

Departments of Pathology.

The distinction of atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) from its benign counterpart, lipoma, may represent a challenge. MDM2 DNA amplification is used as the gold standard as MDM2 immunohistochemistry lacks specificity and sensitivity. Herein, we investigate the diagnostic utility of MDM2 RNA in situ hybridization (RNA-ISH) and compare the test with MDM2 immunohistochemistry and MDM2 DNA fluorescence in situ hybridization (FISH) in benign and malignant lipomatous neoplasms. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001199DOI Listing
December 2018
17 Reads

Novel NTRK3 Fusions in Fibrosarcomas of Adults.

Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.

Rare Cancer Center.

NTRK fusions in malignant tumors are therapeutic targets of tyrosine kinase inhibitors. Because they occur only in a small subset of mesenchymal tumors, knowledge regarding the corresponding histology is important to effectively identify patients who could benefit from targeted therapy. In this study, using RNA sequencing, we identified novel NTRK3 fusions involving related partner genes in 2 adult bone and soft tissue tumors that met the current histologic criteria of fibrosarcoma. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001194DOI Listing
December 2018
20 Reads

The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell Carcinoma of the Salivary Gland.

Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.

Department of Pathology, Stanford University School of Medicine, Stanford, CA.

The spectrum of tumors arising in the salivary glands is wide and has recently been shown to harbor a network of tumor-specific fusion genes. Acinic cell carcinoma (AciCC) is one of the more frequently encountered types of salivary gland carcinoma, but it has remained a genetic orphan until recently when a fusion between the HTN3 and MSANTD3 genes was described in one case. Neither of these 2 genes is known to be implicated in any other malignancy. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001200DOI Listing
December 2018
2 Reads
5.145 Impact Factor

Novel PLAG1 Gene Rearrangement Distinguishes a Subset of Uterine Myxoid Leiomyosarcoma From Other Uterine Myxoid Mesenchymal Tumors.

Am J Surg Pathol 2019 Mar;43(3):382-388

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

Genetic alterations in uterine myxoid leiomyosarcoma are unknown. We investigate the clinicopathologic features of 19 uterine tumors previously diagnosed as myxoid leiomyosarcomas in which tumoral RNA was subjected to targeted RNA sequencing. PLAG1, BCOR, BCORL1, HMGA2, and ALK break-apart fluorescence in situ hybridization (FISH) and BCOR, PLAG1, and ALK immunohistochemistry were performed in cases which failed or lacked fusions by sequencing. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001196DOI Listing
March 2019
3 Reads

Pleomorphic and Florid Lobular Carcinoma In Situ Variants of the Breast: A Clinicopathologic Study of 85 Cases With and Without Invasive Carcinoma From a Single Academic Center.

Am J Surg Pathol 2019 Mar;43(3):399-408

Department of Pathology, University of California San Francisco, San Francisco, CA.

The natural history and optimal treatment of pleomorphic (PLCIS) and florid (FLCIS) lobular carcinoma in situ variants remains uncertain. We reviewed the clinicopathologic features and management of LCIS variants at our institution over a 20-year period. Of 85 cases (61 PLCIS, 24 FLCIS), 77% were associated with invasive carcinoma (84% lobular, 13% ductal/lobular, 3% ductal) and only 17% (9 PLCIS, 5 FLCIS) were pure. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001191DOI Listing
March 2019
13 Reads

A Combined Morphologic and Molecular Approach to Retrospectively Identify KRAS-Mutated Mesonephric-like Adenocarcinomas of the Endometrium.

Am J Surg Pathol 2019 Mar;43(3):389-398

Department of Pathology, Division of Women's and Perinatal Pathology.

An unusual subset of endometrial carcinoma, the mesonephric-like adenocarcinomas, are morphologically and molecularly similar to mesonephric carcinoma, characterized by KRAS mutation and lack of microsatellite instability. They also have a unique immunohistochemical profile and are usually positive for GATA-3, CD10, TTF-1, and negative for ER and PR. This study implemented a combined morphologic and molecular approach to retrospectively identify mesonephric-like carcinomas of the endometrium. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001193DOI Listing
March 2019
2 Reads

Displaced Cartilage Within Lymph Node Parenchyma is a Novel Biopsy Site Change in Resected Mediastinal Lymph Nodes Following EBUS-TBNA.

Am J Surg Pathol 2018 Nov 20. Epub 2018 Nov 20.

Department of Pathology, Cleveland Clinic.

Biopsy site changes in mediastinal lymph nodes (LNs) attributable to prior endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) have not been studied in a systematic manner. Twenty-four contributors from 14 institutions in 5 countries collaborated via social media (Twitter) to retrospectively review consecutive cases of resected mediastinal LNs from patients with prior EBUS-TBNA. Resected LNs were reexamined by submitting pathologists for changes attributable to EBUS-TBNA. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001197DOI Listing
November 2018
3 Reads
5.145 Impact Factor

Distinct Genomic Patterns in Pigmented Epithelioid Melanocytoma: A Molecular and Histologic Analysis of 16 Cases.

Am J Surg Pathol 2018 Nov 20. Epub 2018 Nov 20.

Dermatology, Feinberg School of Medicine, Northwestern University.

Pigmented epithelioid melanocytoma (PEM) is considered an intermediate grade melanocytic lesion that is histologically indistinguishable from epithelioid blue nevi associated with Carney complex. PEM are characterized by an intradermal population of heavily pigmented epithelioid-shaped melanocytes along with some spindled and dendritic melanocytes with frequent melanophages. These melanocytic tumors occasionally involve regional lymph nodes but only rarely result in distant metastases. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001195DOI Listing
November 2018
14 Reads

Tumor Budding and Cell Nest Size Are Highly Prognostic in Laryngeal and Hypopharyngeal Squamous Cell Carcinoma: Further Evidence for a Unified Histopathologic Grading System for Squamous Cell Carcinomas of the Upper Aerodigestive Tract.

Am J Surg Pathol 2019 Mar;43(3):303-313

Institute of Pathology, Technical University of Munich.

Squamous cell carcinoma (SCC) is the most common cancer of the head and neck region including-among others-laryngeal (LSCC) and hypopharyngeal (HSCC) subsites. LSCC/HSCC are heterogenous diseases with respect to patient outcome. Currently, tumor stage-based patient stratification is essential to predict prognosis and thus selection of the appropriate treatment modalities. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001178DOI Listing
March 2019
5 Reads

Patterns of Urachal Remnant Involvement by Urothelial Carcinoma: Intraluminal Noninvasive Spread can Mimic a Deep-seated Bladder Invasion.

Am J Surg Pathol 2018 Nov 20. Epub 2018 Nov 20.

Departments of Pathology.

Benign urachal remnants can be encountered in the adult urinary bladder and it is recognized that these can uncommonly give rise to urachal urothelial carcinoma. However, urachal remnants containing urothelial carcinoma incidentally encountered in cystectomies for bladder cancer has not been previously described. Herein, we present 8 adult bladder cancer cystectomies with incidental urachal remnants containing urothelial carcinoma. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001192DOI Listing
November 2018
3 Reads

Morphologic Overlap Between Inflammatory Myofibroblastic Tumor and IgG4-related Disease: Lessons From Next-generation Sequencing.

Am J Surg Pathol 2019 Mar;43(3):314-324

Department of Pathology, Massachusetts General Hospital, Boston, MA.

Inflammatory myofibroblastic tumor (IMT), a locally aggressive neoplasm capable of metastasis, may show an immunoglobulin (Ig)G4-rich lymphoplasmacytic infiltrate. Prior reports suggest that storiform-fibrosis and obliterative phlebitis aid in the distinction of IMT from IgG4-related diseases. Herein, we highlight the morphologic overlap between the 2 diseases, and emphasize the importance of a multiplex fusion assay in the distinction of IgG4-related disease (IgG4-RD) from IMT. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001167DOI Listing
March 2019
20 Reads

Molecular Profiling of Pheochromocytoma and Abdominal Paraganglioma Stratified by the PASS Algorithm Reveals Chromogranin B as Associated With Histologic Prediction of Malignant Behavior.

Am J Surg Pathol 2019 Mar;43(3):409-421

Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, CCK.

Pheochromocytomas (PCCs) and abdominal paragangliomas (PGLs), collectively abbreviated PPGL, are believed to exhibit malignant potential-but only subsets of cases will display full-blown malignant properties. The Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) algorithm is a proposed histologic system to detect potential for aggressive behavior, but little is known regarding the coupling to underlying molecular genetics. In this study, a total of 92 PPGLs, previously characterized for susceptibility gene status and mRNA expressional profiles, were histologically assessed using the PASS criteria. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001190DOI Listing
March 2019
10 Reads

SMARCA4-deficient Thoracic Sarcomas: Clinicopathologic Study of 30 Cases With an Emphasis on Their Nosology and Differential Diagnoses.

Am J Surg Pathol 2018 Nov 16. Epub 2018 Nov 16.

Bergonie Institute, Department of Pathology, Bordeaux, France.

SMARCA4-deficient thoracic sarcoma (SMARCA4-DTS) is a recently described entity with an aggressive clinical course and specific genetic alterations of the BAF chromatin remodeling complex. In the present study, we reviewed the clinical and pathologic features of 30 cases of SMARCA4-DTS, discussed its main differential diagnoses and the challenging diagnostic scenarios that the average pathologist may face. In addition, we tested the specificity of the "SMARCA4-DTS immunohistochemical signature" (co-loss of SMARCA4 and SMARCA2 with overexpression of SOX2) in a large cohort of intrathoracic malignancies. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001188DOI Listing
November 2018
15 Reads

Papillary Adenomas and Other Small Epithelial Tumors in the Kidney: An Autopsy Study.

Am J Surg Pathol 2019 Feb;43(2):277-287

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.

The aim of this work was to study small neoplasms of the epithelium of the renal tubules; kidneys from 402 unselected autopsies were sectioned at 1 to 2 mm intervals. All lesions were examined histologically. A total of 232 papillary adenomas were found in 76 patients (19%), ranging from 1 to 35 adenomas/patient (mean: 3, median: 2). Read More

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http://dx.doi.org/10.1097/PAS.0000000000001189DOI Listing
February 2019
10 Reads

The Spectrum of EBV-Positive Mucocutaneous Ulcer: A Study of 9 Cases.

Am J Surg Pathol 2019 Feb;43(2):201-210

Department of Pathology, Fundación Jiménez Díaz University Hospital and CIBERONC, Madrid.

We describe a series of 9 patients with Epstein-Barr virus (EBV)-positive mucocutaneous lymphoproliferative lesions that broadens the concept of EBV-positive mucocutaneous ulcer. We report 5 female and 4 male patients, with an average age of 74 years (range, 55 to 87 y), 2 of whom were HIV-positive. The lesions were located in the oropharynx, skin, and rectal and/or genital mucosa. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001186DOI Listing
February 2019
3 Reads

Clinicopathologic Features of CIC-NUTM1 Sarcomas, a New Molecular Variant of the Family of CIC-Fused Sarcomas.

Am J Surg Pathol 2019 Feb;43(2):268-276

Cancer Research Center of Lyon, University of Lyon, Université Claude Bernard Lyon 1, CNRS 5286, INSERM U1052, Lyon.

CIC-fused sarcomas represent an emerging family of tumors, for long connected to the Ewing family group of tumors, but underlined by distinct CIC fusions with different partners. 3' Fusion partners include DUX4, FOXO4, and, as recently emphasized, NUTM1. In this study, we report the clinicopathologic and molecular features of a series of 6 CIC-NUTM1 sarcomas. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001187DOI Listing
February 2019
4 Reads

Hypothalamic Vasopressin-Producing Tumors: Often Inappropriate Diuresis But Occasionally Cushing Disease.

Am J Surg Pathol 2019 Feb;43(2):251-260

Endocrine Oncology Site Group, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

Tumors of hypothalamic neurons that produce vasopressin are rare. We retrieved all cases of vasopressin-positive tumors in the sellar region from the database of the Department of Pathology. Five cases fulfilled the selection criteria, representing the first series of such tumors. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001185DOI Listing
February 2019
2 Reads

Spindle and Round Cell Sarcoma With EWSR1-PATZ1 Gene Fusion: A Sarcoma With Polyphenotypic Differentiation.

Am J Surg Pathol 2019 Feb;43(2):220-228

Department of Pathology.

The evolving classification of round cell sarcomas is driven by molecular alterations. EWSR1-PATZ1 fusion positive spindle and round cell sarcoma is one such new tumor entity. Herein, we report 2 EWSR1-PATZ1 fusion positive spindle and round cell sarcomas with overlapping histologic features and polyphenotypic differentiation. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001183DOI Listing
February 2019
2 Reads

Tenosynovitis With Psammomatous Calcifications: A Distinctive Trauma-Associated Subtype of Idiopathic Calcifying Tenosynovitis With a Predilection for the Distal extremities of Middle-Aged Women-A Report of 23 Cases.

Am J Surg Pathol 2019 Feb;43(2):261-267

Department of Pathology.

The term "idiopathic calcifying tenosynovitis" (ICT) refers to a clinically and radiologically defined syndrome of pain and tendinous calcifications, most often involving the shoulder joint. A distinctive subset of ICT cases, termed "tenosynovitis with psammomatous calcifications" (TPC), occurs in the distal extremities and shows characteristic morphology, in particular psammomatous calcifications. As only 14 cases have been reported to date, TPC remains poorly recognized by both pathologists and clinicians. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001182DOI Listing
February 2019
13 Reads

Utility of Combined EZH2, p-ERK1/2, p-STAT, and MYC Expression in the Differential Diagnosis of EZH2-positive Hodgkin Lymphomas and Related Large B-Cell Lymphomas.

Am J Surg Pathol 2019 Jan;43(1):102-109

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

EZH2 is a methyltransferase that plays an important tumorigenic role in various neoplasms. We previously found that EZH2 is expressed in a range of aggressive B-cell lymphomas (ABCLs), T-cell lymphomas, and histiocytic neoplasms, with differential expression of intracellular signaling molecules p-ERK, MYC, and p-STAT3, potential regulators of EZH2 expression. We studied EZH2 expression in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), classic Hodgkin lymphoma (cHL), T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL), and B-cell Lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphomas and classic Hodgkin lymphoma (BCLu-DLBCL/cHL), as well as the coexpression of p-ERK, MYC, and p-STAT3 in these neoplasms. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001180DOI Listing
January 2019
2 Reads

Mycobacterium chimaera Hepatitis: A New Disease Entity.

Am J Surg Pathol 2019 Feb;43(2):244-250

Division of Infectious Diseases, Kaiser Permanente Southern California, Los Angeles, CA.

Mycobacterium chimaera was identified as a species within the Mycobacterium avium complex in 2004. Until recently, it was predominantly seen in immunocompromised patients. In 2015, an outbreak of disseminated M. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001179DOI Listing
February 2019
17 Reads

Tumor Budding and Prognosis in Gastric Adenocarcinoma.

Am J Surg Pathol 2019 Feb;43(2):229-234

Cancer and Translational Medicine Research Unit, Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland.

Tumor budding has been associated with poor prognosis in several cancer types, but its significance in gastric cancer is unknown. The aim of this study was to assess the prognostic significance of tumor budding in gastric adenocarcinoma, and its main histologic types. Some 583 gastric adenocarcinoma patients who underwent surgery in Oulu University Hospital during the years 1983-2016 were included in this retrospective cohort study. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001181DOI Listing
February 2019
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Epstein-Barr Virus-Associated Pulmonary Carcinoma: Proposing an Alternative Term and Expanding the Histologic Spectrum of Lymphoepithelioma-like Carcinoma of the Lung.

Am J Surg Pathol 2019 Feb;43(2):211-219

Departments of Pathology and Laboratory Medicine.

Lymphoepithelioma-like carcinoma (LELC) of the lung is a rare Epstein-Barr virus (EBV)-associated carcinoma. It is histologically characterized by a syncytial growth pattern with marked lymphocytic infiltration that is indistinguishable from the histology observed in undifferentiated nasopharyngeal carcinomas. However, it has been noted that LELC can display nonclassic morphology and lack significant lymphocytic infiltration. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001173DOI Listing
February 2019
1 Read
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