24,825 results match your criteria The American journal of medicine[Journal]


Advancing the Care of Severe Asthma: Differential Diagnosis, Multidisciplinary Management, and Patient Engagement.

Am J Med 2019 Feb 19. Epub 2019 Feb 19.

Adjunct Professor, Department of Family and Community Health, University of Minnesota, Minneapolis, MN.

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http://dx.doi.org/10.1016/j.amjmed.2019.02.002DOI Listing
February 2019

EFFECTIVENESS AND SAFETY OF OFF-LABEL DOSE-REDUCED DIRECT ORAL ANTICOAGULANTS IN ATRIAL FIBRILLATION.

Am J Med 2019 Feb 15. Epub 2019 Feb 15.

Hematology Institute and Blood Bank, Meir Medical Center, Kfar Saba; Sackler School of Medicine, Tel Aviv University, Tel Aviv.

Background: Direct oral anticoagulants (DOACs) reduce the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation but may result in serious bleeding complications. Off-label dose-reduced use of DOAC to mitigate bleeding is common in routine clinical practice although data regarding its consequences on patient outcomes is limited. Therefore, our objective was to evaluate the effectiveness and safety of off-label dose-reduced versus per-label standard-dose DOAC treatment. Read More

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http://dx.doi.org/10.1016/j.amjmed.2019.01.025DOI Listing
February 2019

Injecting New Ideas Into Managing Type 2 Diabetes: Evolving Roles of GLP-1 Receptor Agonists.

Am J Med 2019 Feb 15. Epub 2019 Feb 15.

Professor of Medicine, The University of Vermont Larner College of Medicine, Director, Endocrinology, The University of Vermont Medical Center, Burlington, Vermont.

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http://dx.doi.org/10.1016/j.amjmed.2019.02.001DOI Listing
February 2019

New Approaches for Delirium: A Case for Robotic Pets.

Am J Med 2019 Feb 7. Epub 2019 Feb 7.

Division of Cardiology, Albany Medical Center, Albany, New York.

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http://dx.doi.org/10.1016/j.amjmed.2018.12.039DOI Listing
February 2019

Body Mass Index, Intensive Blood Pressure Management, and Cardiovascular Events in the Systolic Blood Pressure Intervention Trial (SPRINT).

Am J Med 2019 Feb 2. Epub 2019 Feb 2.

Brigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, Boston, MA, USA. Electronic address:

Background: It is unclear whether intensive blood pressure management is well-tolerated and affects risk uniformly across the body mass index (BMI) spectrum.

Methods: The randomized, controlled Systolic Blood Pressure Intervention Trial (SPRINT) included 9,361 individuals ≥50 years at high cardiovascular risk, without diabetes mellitus, and a systolic blood pressure 130-180 mmHg. Participants were randomized to intensive versus standard antihypertensive treatment and evaluated for the primary composite efficacy endpoint of acute coronary syndromes, stroke, heart failure, or cardiovascular death. Read More

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http://dx.doi.org/10.1016/j.amjmed.2019.01.024DOI Listing
February 2019
1 Read

Graduate Medical Education's Tower of Babel.

Authors:
David W Young

Am J Med 2019 Feb 1. Epub 2019 Feb 1.

Professor, Emeritus of Accounting and Control, Health Sector Management Program, Questrom School of Management at Boston University and President and CEO, The Crimson Group, Inc., Cambridge, Massachusetts January 2019. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.01.026DOI Listing
February 2019

Creating a culture of micro-affirmations to overcome gender-based micro-inequities in academic medicine.

Am J Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Kirstein 3, Boston, MA, 02215, USA; Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, 25 Shattuck St., Boston, MA, 02115, USA.; Division of Women's Health, Brigham and Women's Hospital, 1620 Tremont St., OBC 3, Boston, MA, 02120, USA.

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http://dx.doi.org/10.1016/j.amjmed.2019.01.028DOI Listing
February 2019

A New Gender Neutral Honorific: "RP".

Am J Med 2019 Feb 1. Epub 2019 Feb 1.

From the Division of Infectious Diseases, New York Medical College, Valhalla, NY 10595. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.01.029DOI Listing
February 2019

Clinician's Guide to the Updated ABCs of Cardiovascular Disease Prevention: A Review Part 2.

Am J Med 2019 Feb 1. Epub 2019 Feb 1.

Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Baltimore, MD; National Institute for Preventive Cardiology and National University of Ireland, Galway, Ireland.

Efforts to better control risk factors for cardiovascular disease and prevent the development of subsequent cardiovascular events are crucial to maintaining healthy populations. In today's busy practice environment and with the overwhelming pace of new research findings, ensuring appropriate emphasis and implementation of evidence-based preventive cardiovascular care can be challenging. The ABCDEF approach to cardiovascular disease prevention is intended to improve dissemination of contemporary best practices and ease the implementation of comprehensive preventive strategies for clinicians. Read More

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http://dx.doi.org/10.1016/j.amjmed.2019.01.031DOI Listing
February 2019

Chronic Myocardial Injury and Risk for Stroke.

Am J Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Medicine, Karolinska Institutet, Solna, SE-171 71 Stockholm, Sweden; Functional Area of Emergency Medicine, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm, Sweden. Electronic address:

Background And Purpose: Chronic myocardial injury defined as persistent troponin levels >99th percentile values when measured with high-sensitivity assays (hs-cTn) is common. The association between chronic myocardial injury and stroke is unknown. This study aimed to investigate the association between chronic myocardial injury and stroke. Read More

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http://dx.doi.org/10.1016/j.amjmed.2019.01.027DOI Listing
February 2019
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Burden of Thirty-Day Readmissions Associated with Discharge Against Medical Advice Among Inpatients in the United States.

Authors:
Nilay Kumar

Am J Med 2019 Feb 1. Epub 2019 Feb 1.

Division of Hospital Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI. Electronic address:

Background And Objectives: Discharges against medical advice are common among inpatients in the United States. The impact of discharge against medical advice on readmission rates and subsequent hospitalization outcomes is uncertain. We sought to ascertain the effect of discharge against medical advice on 30-day readmission rates and outcomes of readmission. Read More

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http://dx.doi.org/10.1016/j.amjmed.2019.01.023DOI Listing
February 2019

Animals in the Hospital.

Authors:
Joseph S Alpert

Am J Med 2019 Jan 31. Epub 2019 Jan 31.

University of Arizona College of Medicine, Tucson; Editor-in-Chief, The American Journal of Medicine. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.01.010DOI Listing
January 2019

Spontaneous Pneumothorax in a Young Woman.

Am J Med 2019 Jan 30. Epub 2019 Jan 30.

Longmont United Hospital, 1950 West Mountain View Avenue, Longmont, Colorado, 80501.

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http://dx.doi.org/10.1016/j.amjmed.2019.01.013DOI Listing
January 2019
1 Read

Diffuse vascular FDG uptake in late onset Takayasu arteritis.

Am J Med 2019 Jan 30. Epub 2019 Jan 30.

Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama 700-8558, Japan.

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http://dx.doi.org/10.1016/j.amjmed.2019.01.018DOI Listing
January 2019
1 Read

Artificial Intelligence Transforms the Future of Healthcare.

Am J Med 2019 Jan 30. Epub 2019 Jan 30.

Biocomplexity Institute, Virginia Tech, 1015 Life Sciences Circle, Blacksburg, VA, 24060, USA; Biomedical and Translational Informatics Institute, Geisinger Health System, 100 N Academy Ave, Danville, PA, 17822, USA.

Life sciences researchers using Artificial Intelligence are under pressure to innovate faster than ever. Large, multilevel, and integrated datasets offer the promise of unlocking novel insights and accelerating breakthroughs. Although more data are available than ever, only a fraction is being curated, integrated, understood, and analyzed. Read More

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http://dx.doi.org/10.1016/j.amjmed.2019.01.017DOI Listing
January 2019

Presumed Pancreatitis in the Setting of Renal Impairment.

Am J Med 2019 Jan 30. Epub 2019 Jan 30.

Department of Internal Medicine, Division of Critical Care Medicine, The Brooklyn Hospital Center, Brooklyn, New York, USA.

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http://dx.doi.org/10.1016/j.amjmed.2019.01.022DOI Listing
January 2019

Clinician's Guide to the Updated ABCs of Cardiovascular Disease Prevention: A Review Part 1.

Am J Med 2019 Jan 30. Epub 2019 Jan 30.

Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Baltimore, MD; National Institute for Preventive Cardiology and National University of Ireland, Galway, Ireland.

Efforts to better control risk factors for cardiovascular disease and prevent the development of subsequent events are crucial to maintaining healthy populations. In today's busy practice environment and with the overwhelming pace of new research findings, ensuring appropriate emphasis and implementation of evidence-based preventive cardiovascular care can be challenging. The ABCDEF approach to cardiovascular disease prevention is intended to improve dissemination of contemporary best practices and facilitate the implementation of comprehensive preventive strategies for clinicians. Read More

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http://dx.doi.org/10.1016/j.amjmed.2019.01.016DOI Listing
January 2019
2 Reads

Pearls and Myths in the Evaluation of Patients with Suspected Acute Pulmonary Embolism.

Am J Med 2019 Jan 30. Epub 2019 Jan 30.

Department of Internal Medicine, Clinic for Internal Medicine, City Hospital Triemli Zurich, Zurich, Switzerland.

Significant improvement has been achieved in diagnostic accuracy, validation of probability scores and standardized treatment algorithms for patients with suspected acute pulmonary embolism. These developments have provided the tools for a safe and cost-effective management for most of these patients. To our experience, however, the presence of medical myths and ongoing controversies appear to hinder the implementation of these tools in everyday clinical practice. Read More

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http://dx.doi.org/10.1016/j.amjmed.2019.01.011DOI Listing
January 2019
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Recurrent Abdominal Pain in Systemic Lupus Erythematosus: Concurrent Lupus Enteritis and Lupus Cystitis.

Am J Med 2019 Jan 30. Epub 2019 Jan 30.

Division of Rheumatology, Department of Internal Medicine, School of Medicine, Universidad de Antioquia, Medellín, Colombia. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.01.021DOI Listing
January 2019
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New Treatment Options for Depression: A Primer for Internists.

Am J Med 2019 Jan 30. Epub 2019 Jan 30.

Division of Community Internal Medicine, Mayo Clinic, Scottsdale, Arizona.

Depression continues to be a challenging condition to treat despite the myriad treatment options available. Primary care providers are increasingly tasked with providing second- and third-line treatments for major depressive disorder and, thus, should be familiar with newer medication therapies that are available. In this article, we aim to provide the general internist and other providers who treat depression in their practice with a succinct review of recent developments in the treatment of depression. Read More

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http://dx.doi.org/10.1016/j.amjmed.2019.01.012DOI Listing
January 2019

Aortic root abscess in a patient with Marfan's syndrome.

Am J Med 2019 Jan 30. Epub 2019 Jan 30.

Department of Cardiology, South West Acute Hospital, Western Health and Social Care Trust, Enniskillen, Northern Ireland, United Kingdom.

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http://dx.doi.org/10.1016/j.amjmed.2019.01.009DOI Listing
January 2019
2 Reads

A Case of Miller Fisher Syndrome.

Am J Med 2019 Jan 30. Epub 2019 Jan 30.

St Vincent Charity Medical Center, Department of Medicine, Cleveland, Ohio.

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http://dx.doi.org/10.1016/j.amjmed.2019.01.014DOI Listing
January 2019
1 Read

More martial than arts: Coronary artery dissection after chest kick.

Am J Med 2019 Jan 30. Epub 2019 Jan 30.

Hospital Universitari Parc Taulí, Servei de Cardiología, Parc Taulí, 1, 08208 Sabadell, Barcelona Spain.

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http://dx.doi.org/10.1016/j.amjmed.2019.01.019DOI Listing
January 2019

An Overlooked Cause of Polyuria.

Am J Med 2019 Feb 25;132(2):e33-e34. Epub 2018 Oct 25.

Department of General Medicine, Government Medical College and Hospital, Chandigarh, India.

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http://dx.doi.org/10.1016/j.amjmed.2018.09.035DOI Listing
February 2019

Evidence Basis for a Point-of-Care Ultrasound Examination to Refine Referral for Outpatient Echocardiography.

Am J Med 2019 Feb 25;132(2):227-233. Epub 2018 Oct 25.

Department of Cardiology and Graduate Medical Education, Scripps Mercy Hospital, San Diego, Calif. Electronic address:

Background: Few data exist on the potential utility of a cardiac point-of-care ultrasound (POCUS) examination in the outpatient setting to assist diagnosis of significant cardiac disease. Using a retrospective sequential cohort design, we sought to derive and then validate a POCUS examination for cardiac application and model its potential use for prognostication and cost-effective echo referral.

Methods: For POCUS examination derivation, we reviewed 233 consecutive outpatient echo studies for 4 specific POCUS "signs" contained therein representing left ventricular systolic dysfunction, left atrial enlargement, inferior vena cava plethora, and lung apical B-lines. Read More

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http://dx.doi.org/10.1016/j.amjmed.2018.10.012DOI Listing
February 2019

The Association Between Serum Calcium Levels and Short-Term Mortality in Patients with Chronic Heart Failure.

Am J Med 2019 Feb 26;132(2):200-208.e1. Epub 2018 Oct 26.

Department of Cardiology, Aalborg University Hospital, Denmark; Unit of Epidemiology and Biostatistics, Aalborg University Hospital, Denmark.

Background: Patients with chronic heart failure have vulnerable myocardial function and are susceptible to electrolyte disturbances. In these patients, diuretic treatment is frequently prescribed, though it is known to cause electrolyte disturbances. Therefore, we investigated the association between altered calcium homeostasis and the risk of all-cause mortality in chronic heart failure patients. Read More

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http://dx.doi.org/10.1016/j.amjmed.2018.10.006DOI Listing
February 2019
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Concomitant Use of Direct Oral Anticoagulants with Antiplatelet Agents and the Risk of Major Bleeding in Patients with Nonvalvular Atrial Fibrillation.

Am J Med 2019 Feb 25;132(2):191-199.e12. Epub 2018 Oct 25.

Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada; Gerald Bronfman Department of Oncology, McGill University, Montreal, Quebec, Canada. Electronic address:

Purpose: Patients with nonvalvular atrial fibrillation commonly have comorbidities requiring concurrent use of oral anticoagulants and antiplatelets. There are no real-world data on the comparative safety of concomitant antithrombotic treatments in the era of direct oral anticoagulant (DOACs). Thus, we compared the incidence of intracranial hemorrhage, gastrointestinal bleeding, and other major bleeding between concomitant DOAC-antiplatelet use and concomitant vitamin K antagonist (VKA)-antiplatelet use in patients with nonvalvular atrial fibrillation. Read More

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http://dx.doi.org/10.1016/j.amjmed.2018.10.008DOI Listing
February 2019
1 Read

The Reply.

Am J Med 2019 Feb;132(2):e49

Internal Medicine D and Hypertension Unit, The Chaim Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2018.10.024DOI Listing
February 2019

High-Density Lipoprotein Cholesterol and Hyponatremia: An Unsolved Gordian Knot.

Am J Med 2019 Feb;132(2):e47-e48

Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece.

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https://linkinghub.elsevier.com/retrieve/pii/S00029343183096
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http://dx.doi.org/10.1016/j.amjmed.2018.10.010DOI Listing
February 2019
3 Reads

The Reply.

Am J Med 2019 Feb;132(2):e46

Department of Medicine, New York Medical College/Westchester Medical Center, Valhalla, NY. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2018.10.026DOI Listing
February 2019

The Reply.

Am J Med 2019 Feb;132(2):e44

Clinical Associate Professor, Pediatrics and Medicine, The Warren Alpert Medical School of Brown University, Providence, RI.

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http://dx.doi.org/10.1016/j.amjmed.2018.10.023DOI Listing
February 2019

Altruism - A Quality Required of Medical School Applicants.

Am J Med 2019 Feb;132(2):e43

Cardiff University School of Medicine, Centre for Medical Education, College of Biomedical and Life Sciences, Cardiff, UK. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2018.09.016DOI Listing
February 2019

An Alternative to 'Medicare for All'.

Am J Med 2019 Jan 23. Epub 2019 Jan 23.

U of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.01.007DOI Listing
January 2019
1 Read

Heart failure with preserved ejection fraction: Is ischemia due to coronary microvascular dysfunction a mechanistic factor?

Am J Med 2019 Jan 23. Epub 2019 Jan 23.

Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville, Florida. Electronic address:

Heart failure with preserved ejection fraction (HFpEF) is increasing in prevalence and has no guideline recommended therapy, related in part to a lack of mechanism. Traditionally, HFpEF was thought to be secondary to afterload overload due to systemic hypertension, however, accumulating evidence suggests that HFpEF continues to worsen despite adequate blood pressure control. Emerging data support the suggestion that myocardial ischemia secondary to coronary microvascular dysfunction could be the new paradigm pathophysiology. Read More

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http://dx.doi.org/10.1016/j.amjmed.2018.12.038DOI Listing
January 2019
4 Reads
5.003 Impact Factor

UNDERUTILIZATION OF ASPIRIN IN PATIENTS WITH ADVANCED COLORECTAL POLYPS.

Am J Med 2019 Jan 23. Epub 2019 Jan 23.

First Sir Richard Doll Professor & Senior Academic Advisor to the Dean, Charles E. Schmidt College of Medicine, Florida Atlantic University, 2800 S. Ocean Blvd. PHA, Boca Raton, FL 33432. Electronic address:

Background: Colorectal cancer is the third most common cause of cancer deaths in the United States and advanced colorectal polyps are a major risk factor. Although there are no large-scale individual trials designed a priori to test the hypothesis, in meta-analyses of trials in primary prevention of cardiovascular disease aspirin reduces risk of colorectal cancer. The United States Preventive Services Task Force utilized a micro-simulation model including baseline risk factors and concluded that aspirin reduces risk of colorectal cancer by 40%. Read More

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http://dx.doi.org/10.1016/j.amjmed.2018.12.037DOI Listing
January 2019
1 Read

How Accurate Are the Findings Noted During a Physical Examination?: Will Physicians Stop Performing Physical Examinations? (Part 2).

Authors:
Joseph S Alpert

Am J Med 2019 Jan 24. Epub 2019 Jan 24.

University of Arizona College of Medicine, Tucson; Editor-in-Chief, The American Journal of Medicine. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.01.008DOI Listing
January 2019
1 Read

Take It From Sammy.

Authors:
David B Hellmann

Am J Med 2019 Jan 22. Epub 2019 Jan 22.

Department of Medicine, Johns Hopkins School of Medicine, Baltimore Md. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2018.12.033DOI Listing
January 2019
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Net Clinical Benefit of Non-Vitamin K Antagonist vs Vitamin K Antagonist Anticoagulants in Elderly Patients with Atrial Fibrillation.

Am J Med 2019 Jan 19. Epub 2019 Jan 19.

Institute of Cardiology, G. d'Annunzio University, Chieti, Italy; Fondazione G. Monasterio, Pisa, Italy.

Background: The risks of thromboembolic and hemorrhagic events in patients with atrial fibrillation both increase with age; therefore, net clinical benefit analyses of anticoagulant treatments in the elderly population are crucial to guide treatment. We evaluated the 1-year clinical outcomes with non-vitamin-K antagonist and vitamin K antagonist oral anticoagulants (NOACs vs VKAs) in elderly (≥75 years) patients with atrial fibrillation in a prospective registry setting.

Methods: Data on 3825 elderly patients were pooled from the PREFER in AF and PREFER in AF PROLONGATION registries. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029343193007
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http://dx.doi.org/10.1016/j.amjmed.2018.12.036DOI Listing
January 2019
5 Reads

Real-Life Benefits of Statins for Cardiovascular Prevention in Elderly Subjects: A Population-Based Cohort Study.

Am J Med 2019 Jan 18. Epub 2019 Jan 18.

University Bordeaux, Institut National de la Santé et de la Recherche Médicale (INSERM), Bordeaux Population Health Research Center, Team Pharmacoepidemiology, Unité Mixte de Recherche (UMR) 1219, Bordeaux, France; Centre Hospitalier Universitaire (CHU) de Bordeaux, Bordeaux, France.

Objectives: The benefits of initiating statins in the elderly remains debated. We evaluated the effects of initiating statins in the elderly, according to cardiovascular risk.

Methods: This population-based cohort study used data of the representative sample of the French health care system database for the 2008-2015 period. Read More

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http://dx.doi.org/10.1016/j.amjmed.2018.12.032DOI Listing
January 2019
2 Reads

Anticoagulation Therapy in Patients with Liver Cirrhosis is Associated With an Increased Risk of Variceal Hemorrhage.

Am J Med 2019 Jan 18. Epub 2019 Jan 18.

Department of Medicine, Medical University of South Carolina, Charleston. Electronic address:

Objective: The belief that cirrhotic patients are "auto-anticoagulated" often results in anticoagulation therapy being withheld in these patients. We aimed to understand patterns of use of anticoagulation and to determine the risk of bleeding complications in cirrhotic patients.

Methods: We retrospectively analyzed 320 cirrhotic patients treated with anticoagulation therapy from July 15, 2014 to January 30, 2018. Read More

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http://dx.doi.org/10.1016/j.amjmed.2019.01.006DOI Listing
January 2019
2 Reads

The Reply.

Am J Med 2019 Jan 16. Epub 2019 Jan 16.

Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing.

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http://dx.doi.org/10.1016/j.amjmed.2018.12.013DOI Listing
January 2019
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Clinical Characteristics and Etiologies of Miliary Nodules in the US: A Single-Center Study.

Am J Med 2019 Jan 16. Epub 2019 Jan 16.

Divisions of Critical Care, Pulmonary and Sleep Medicine, Department of Internal Medicine. Electronic address:

Background: Miliary nodules have been typically described as a radiological manifestation of disseminated tuberculosis. However, miliary nodules are known to occur in a wide variety of conditions. The primary objective of the study was to identify clinical characteristics and etiologies of miliary nodules within our institution. Read More

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http://dx.doi.org/10.1016/j.amjmed.2018.12.030DOI Listing
January 2019
3 Reads

Short-TErm Psychotherapy IN Acute Myocardial Infarction (STEP-IN-AMI) Trial: Final Results.

Am J Med 2019 Jan 17. Epub 2019 Jan 17.

Interventional Cardiology Unit, San Filippo Neri Hospital, Rome, Italy.

Purpose: The purpose of this research was to assess whether short-term psychotherapy enhances long-term clinical outcomes in patients with a recent acute myocardial infarction (AMI).

Methods: Patients ≤70 years old were randomized within 1 week of their AMI to short-term ontopsychological psychotherapy plus routine medical therapy vs routine medical therapy only. The primary composite outcome was defined as the combined incidence of new cardiovascular events (re-infarction, death, stroke, revascularization, life-threatening ventricular arrhythmias, and the recurrence of clinically significant angina) and clinically significant new comorbidities. Read More

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http://dx.doi.org/10.1016/j.amjmed.2018.12.025DOI Listing
January 2019
5 Reads

Consumer-Directed Health Care: The Uncertain Future of Price Transparency Initiatives.

Am J Med 2019 Jan 16. Epub 2019 Jan 16.

The Warren Alpert Medical School, Brown University, Providence, RI.

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http://dx.doi.org/10.1016/j.amjmed.2018.12.031DOI Listing
January 2019
1 Read

The Rheumatoid Hands of Renoir.

Am J Med 2019 Jan 16. Epub 2019 Jan 16.

Worcester Royal Eye Unit, Worcestershire Royal Hospital, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029343193006
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http://dx.doi.org/10.1016/j.amjmed.2018.12.034DOI Listing
January 2019
4 Reads
5.003 Impact Factor

Pulse Pressure, Cardiovascular Events, and Intensive Blood-Pressure Lowering in the Systolic Blood Pressure Intervention Trial (SPRINT).

Am J Med 2019 Jan 16. Epub 2019 Jan 16.

Brigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, Boston, Mass. Electronic address:

Background: The efficacy and tolerability of intensive blood-pressure lowering may vary by pulse pressure (systolic minus diastolic blood pressure).

Methods: SPRINT randomized 9361 high-risk adults without diabetes and who were ≥50 years with systolic blood pressure 130-180 mm Hg to intensive or standard antihypertensive treatment. The primary efficacy end point was the composite of acute coronary syndromes, stroke, heart failure, or death from cardiovascular causes. Read More

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http://dx.doi.org/10.1016/j.amjmed.2019.01.001DOI Listing
January 2019
3 Reads

ABC (Atrial fibrillation Better Care) Pathway and Healthcare Costs in Atrial Fibrillation: The ATHERO-AF Study.

Am J Med 2019 Jan 16. Epub 2019 Jan 16.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, UK; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Denmark. Electronic address:

Background: The Atrial fibrillation Better Care (ABC) pathway has been proposed to streamline patient management in an integrated, holistic manner. Compliance to ABC resulted in lower incidence of cardiovascular events, but its impact on health-related costs has not been evaluated.

Methods: Exploratory analysis of costs related to cardiovascular events in the ATHERO-AF prospective cohort study including atrial fibrillation patients on vitamin K antagonists. Read More

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http://dx.doi.org/10.1016/j.amjmed.2019.01.003DOI Listing
January 2019
2 Reads

Periprocedural Bridging in Patients with Venous Thromboembolism: A Systematic Review.

Am J Med 2019 Jan 16. Epub 2019 Jan 16.

Division of Hospital Medicine, University of California, San Francisco. Electronic address:

Background: Vitamin K antagonists (VKA) are the most widely used anticoagulants, and bridging is commonly administered during periprocedural VKA interruption. Given the unclear benefits and risks of periprocedural bridging in patients with previous venous thromboembolism, we aimed to assess recurrent venous thromboembolism and bleeding outcomes with and without bridging in this population.

Methods: We performed a systematic review searching the PubMed and Embase databases from inception to December 7, 2017 for randomized and nonrandomized studies that included adults with previous venous thromboembolism requiring VKA interruption to undergo an elective procedure, and that reported venous thromboembolism or bleeding outcomes. Read More

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http://dx.doi.org/10.1016/j.amjmed.2019.01.004DOI Listing
January 2019
1 Read