20,890 results match your criteria The American journal of gastroenterology[Journal]


Response to Gupta and Hanauer.

Am J Gastroenterol 2019 Feb 14. Epub 2019 Feb 14.

Division of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.

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http://dx.doi.org/10.14309/ajg.0000000000000160DOI Listing
February 2019

Anticoagulation for Portal Vein Thrombosis in Cirrhosis.

Authors:
Andrea Mancuso

Am J Gastroenterol 2019 Feb 14. Epub 2019 Feb 14.

Medicina Interna 1, ARNAS Civico-Di Cristina-Benfratelli, Palermo, Italy.

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http://dx.doi.org/10.14309/ajg.0000000000000158DOI Listing
February 2019

From Latin America With Love (for the Red Journal).

Authors:
Pablo Luna

Am J Gastroenterol 2019 Feb 14. Epub 2019 Feb 14.

Gastroenterology and Endoscopy Units, Hospital Alemán, Buenos Aires, Argentina.

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http://dx.doi.org/10.14309/ajg.0000000000000157DOI Listing
February 2019

Diagnosis and Treatment of Rumination Syndrome: A Critical Review.

Am J Gastroenterol 2019 Feb 13. Epub 2019 Feb 13.

Eating Disorders Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.

Rumination syndrome (RS) is characterized by the repeated regurgitation of material during or soon after eating with the subsequent rechewing, reswallowing, or spitting out of the regurgitated material. Rumination syndrome is classified as both a "Functional Gastroduodenal Disorder" (by the Rome Foundation's Functional Gastrointestinal Disorders: Disorders of Gut-Brain Interaction, 4th edition) and a "Feeding and Eating Disorder" (by the Diagnostic and Statistical Manual of Mental Disorders, 5th edition). Rumination syndrome is a disorder that is often inaccurately diagnosed or missed, resulting in patients experiencing protracted symptoms and not receiving treatment for long periods. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000060DOI Listing
February 2019

Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic Pancreatitis.

Am J Gastroenterol 2019 Feb 13. Epub 2019 Feb 13.

Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA.

Objectives: Premature activation of the digestive protease trypsin within the pancreatic parenchyma is a critical factor in the pathogenesis of pancreatitis. Alterations in genes that affect intrapancreatic trypsin activity are associated with chronic pancreatitis (CP). Recently, carboxyl ester lipase emerged as a trypsin-independent risk gene. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000051DOI Listing
February 2019

Participation and Ease of Use in Colorectal Cancer Screening: A Comparison of 2 Fecal Immunochemical Tests.

Am J Gastroenterol 2019 Feb 14. Epub 2019 Feb 14.

Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Introduction: The impact of fecal immunochemical test (FIT)-based colorectal cancer (CRC) screening on disease incidence and mortality is affected by participation, which might be influenced by ease of use of the FIT. We compared the participation rates and ease of use of 2 different FITs in a CRC screening program.

Methods: There were two study designs within the Dutch CRC screening program. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000148DOI Listing
February 2019

Response to Kedarisetty.

Am J Gastroenterol 2019 Feb 15. Epub 2019 Feb 15.

Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.14309/ajg.0000000000000161DOI Listing
February 2019

Ideal Screening for Gastric Cancer Might Vary Across Different Regions Worldwide.

Authors:
Kyosuke Kaji

Am J Gastroenterol 2019 Feb 12. Epub 2019 Feb 12.

Kanazawa Medical Association, Kanazawa, Ishikawa Japan.

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http://dx.doi.org/10.14309/ajg.0000000000000159DOI Listing
February 2019

Placing Value on Telemedicine for Inflammatory Bowel Disease.

Authors:
Corey A Siegel

Am J Gastroenterol 2019 Jan 30. Epub 2019 Jan 30.

Section of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.

Telemedicine can take a number of forms. A popular approach is the use of telemonitoring, which takes advantage of available technology to follow patients remotely. Cross and colleagues present the results of a well-done randomized controlled trial to assess the impact of a telemonitoring program for patients with inflammatory bowel disease. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000151DOI Listing
January 2019

A High Prevalence of Gastrointestinal Manifestations in Common Variable Immunodeficiency.

Am J Gastroenterol 2019 Feb 8. Epub 2019 Feb 8.

Department of Gastroenterology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Objectives: Common variable immunodeficiency (CVID) is associated with a spectrum of autoimmune complications. We studied the prevalence of gastrointestinal (GI) manifestations and infections in patients with CVID.

Methods: Complete clinical data of 132 Finnish patients with CVID (106 probable and 26 possible CVID) followed up between 2007 and 2016 were collected to a structured database. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000140DOI Listing
February 2019
1 Read

Surveillance Colonoscopy for Ulcerative Colitis-Associated Colorectal Cancer Offers Better Overall Survival in Real-World Surgically Resected Cases.

Am J Gastroenterol 2019 Feb 8. Epub 2019 Feb 8.

Internal Medicine, Sakura Medical Center, Toho University, Tokyo, Japan.

Objectives: To determine the effectiveness of surveillance colonoscopy (SC) and optimize its use by assessing real-world surgically resected cases of ulcerative colitis (UC)-associated colorectal cancer (CRC) and dysplasia.

Methods: Clinicopathological data of 406 (238 CRC and 168 dysplasia) patients who underwent surgical resection in 10 UC specialized institutions were retrospectively reviewed. The overall survival (OS) rates were compared between the SC and non-SC groups. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000117DOI Listing
February 2019
2 Reads

The Clinician's Guide to Suspected Small Bowel Bleeding.

Am J Gastroenterol 2018 Dec 20. Epub 2018 Dec 20.

Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Scottsdale, AZ, USA.

Small bowel bleeding accounts for 5-10% of gastrointestinal bleeding. With the advent of capsule endoscopy, device-assisted enteroscopy, and multiphase CT scanning, a small bowel source can now be found in many instances of what has previously been described as obscure gastrointestinal bleeding. We present a practical review on the evaluation and management of small bowel bleeding for the practicing clinician. Read More

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http://dx.doi.org/10.1038/s41395-018-0424-xDOI Listing
December 2018
7 Reads

Chronic Pancreatitis Is Characterized by Distinct Complication Clusters That Associate With Etiological Risk Factors.

Am J Gastroenterol 2019 Feb 5. Epub 2019 Feb 5.

Centre for Pancreatic Diseases, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.

Objectives: Chronic pancreatitis (CP) is characterized by several disease-related complications and multiple etiological risk factors. Past studies of associations between complications and risk factors have mostly been limited to single complications or highly focused on single etiologies. Using an objective data-driven approach (cluster analysis), we characterized complication clusters and their associations with etiological risk factors in a large cohort of patients with CP. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000147DOI Listing
February 2019
1 Read
10.755 Impact Factor

Esophagogastric Junction Distensibility on Functional Lumen Imaging Probe Topography Predicts Treatment Response in Achalasia-Anatomy Matters!

Am J Gastroenterol 2019 Feb 5. Epub 2019 Feb 5.

Division of Gastroenterology and Hepatology, Northwestern Medicine, Chicago, Illinois, USA.

Introduction: To compare the utility of the distensibility index (DI) on functional lumen imaging probe (FLIP) topography to other esophagogastric junction (EGJ) metrics in assessing treatment response in achalasia in the context of esophageal anatomy.

Methods: We prospectively evaluated 79 patients (at ages 17-81 years; 47% female patients) with achalasia during follow-up after pneumatic dilation, Heller myotomy, or per-oral endoscopic myotomy with timed barium esophagram, high-resolution impedance manometry, and FLIP. Anatomic deformities were identified based on consensus expert opinion. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000137DOI Listing
February 2019
1 Read

Individualized Dynamics in the Gut Microbiota Precede Crohn's Disease Flares.

Am J Gastroenterol 2019 Feb 5. Epub 2019 Feb 5.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objectives: Crohn's disease (CD) is a chronic relapsing-remitting gut inflammatory disorder with a heterogeneous unpredictable course. Dysbiosis occurs in CD; however, whether microbial dynamics in quiescent CD are instrumental in increasing the risk of a subsequent flare remains undefined.

Methods: We analyzed the long-term dynamics of microbial composition in a prospective observational cohort of patients with quiescent CD (45 cases, 217 samples) over 2 years or until clinical flare occurred, aiming to identify whether changes in the microbiome precede and predict clinical relapse. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000136DOI Listing
February 2019

Response to He et al.

Am J Gastroenterol 2019 Feb 5. Epub 2019 Feb 5.

Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.

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http://dx.doi.org/10.14309/ajg.0000000000000150DOI Listing
February 2019

Burden and Cost of Outpatient Hemorrhoids in the United States Employer-Insured Population, 2014.

Am J Gastroenterol 2019 Feb 7. Epub 2019 Feb 7.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina.

Introduction: Although hemorrhoids are a common indication for seeking health care, there are no contemporary estimates of burden and cost. We examined data from an administrative claims database to estimate health care use and aggregate costs.

Methods: We conducted a cross-sectional study using the MarketScan Commercial Claims and Encounters Database for 2014. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000143DOI Listing
February 2019
1 Read

Development and Validation of a Novel Diagnostic Nomogram to Differentiate Between Intestinal Tuberculosis and Crohn's Disease: A 6-year Prospective Multicenter Study.

Am J Gastroenterol 2019 Feb 7. Epub 2019 Feb 7.

Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.

Objectives: Differentiating Crohn's disease (CD) from intestinal tuberculosis (ITB) remains a diagnostic challenge. Misdiagnosis carries potential grave implications. We aimed to develop and validate a novel diagnostic nomogram for differentiating them. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000064DOI Listing
February 2019
7 Reads

Early-Stage Hepatocellular Carcinoma: Radiofrequency Ablation or Resection?

Am J Gastroenterol 2019 Feb;114(2):359

Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning Province, China.

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http://dx.doi.org/10.14309/ajg.0000000000000131DOI Listing
February 2019
3 Reads

A Randomized Trial of Topical Epinephrine and Rectal Indomethacin for Preventing Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis in High-Risk Patients.

Am J Gastroenterol 2019 Feb;114(2):339-347

Division of Gastroenterology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

Introduction: Rectal indomethacin and topical spray of epinephrine have separately shown efficacy in the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) in randomized controlled trials. We hypothesized that the combination of indomethacin and topical spray of epinephrine on the duodenal papillae would further reduce PEP than when indomethacin was used alone.

Methods: We conducted a comparative effectiveness, multicenter, double-blinded, randomized trial of rectal indomethacin alone vs a combination of rectal indomethacin and topical spray of epinephrine for the prevention of PEP in high-risk patients. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000049DOI Listing
February 2019
4 Reads

Comparing the Real-World Effectiveness of Competing Colonoscopy Preparations: Results of a Prospective Trial.

Am J Gastroenterol 2019 Feb;114(2):305-314

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Objectives: National societies provide little guidance regarding which colonoscopy bowel preps are best tolerated and most effective; this reflects a lack of comparative effectiveness studies that directly evaluate the available preps in a "real-world" setting. To address this gap, we conducted a prospective, commercially unfunded comparative effectiveness study of currently available bowel preps and measured their impact on bowel cleansing.

Methods: We included patients aged ≥18 years, who presented for an outpatient colonoscopy at a large medical center serving more than 70 academic and community-based endoscopists who are free to prescribe the bowel prep of their choice. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000057DOI Listing
February 2019
4 Reads

Fracture Risk in Patients With Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study From 1964 to 2014.

Am J Gastroenterol 2019 Feb;114(2):291-304

Patient Area Gastroenterology, Dermatovenerology and Rheumatology, Inflammation and Infection Theme Karolinska University Hospital, Stockholm, Sweden.

Introduction: Most studies on fractures in inflammatory bowel disease (IBD) are based on patients from tertiary centers or patients followed up before the introduction of immunomodulators or biologics. In addition, the role of corticosteroids in fracture risk has rarely been examined.

Methods: We conducted a nationwide population-based cohort study of 83,435 patients with incident IBD (ulcerative colitis [UC]: n = 50,162, Crohn's disease [CD]: n = 26,763, and IBD unclassified: 6,510) and 825,817 reference individuals from 1964 to 2014. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000062DOI Listing
February 2019
1 Read

Noninvasive Tests for Prognosticating Outcomes in Patients With Chronic Liver Disease in Pregnancy: Ready for Prime Time?

Am J Gastroenterol 2019 Feb;114(2):209-211

University of California, San Francisco, San Francisco, California, USA.

Rates of cirrhosis and pregnancy in women of reproductive age are increasing, making pregnancy-specific prognostic markers of disease severity increasingly important. Gonsalkorala et al. describe albumin-bilirubin score and aspartate aminotransferase-to-platelet ratio index as superior prognostic tools to the Model for End-Stage Liver Disease (MELD) score in predicting live births and gestation beyond 37 weeks in pregnant women with cirrhosis, among 165 pregnancies in women with chronic liver disease. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000101DOI Listing
February 2019

The Unfulfilled Promise of Prokinetics for Functional Dyspepsia/Postprandial Distress Syndrome.

Am J Gastroenterol 2019 Feb;114(2):204-206

Translational Research Center for Gastrointestinal Diseases (TARGID), University of Leuven, Leuven, Belgium.

Functional dyspepsia (FD) is subdivided into epigastric pain syndrome and postprandial distress syndrome according to the Rome IV consensus. Based on the assumption that disordered gastric motility is a key pathophysiologic factor in postprandial distress syndrome, prokinetic agents are often proposed as the treatment of choice for this subgroup. Although a meta-analysis suggests that prokinetic agents may be efficacious and safe in FD, there is a lack of widely available agents of proven efficacy. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000072DOI Listing
February 2019
6 Reads

The "Doughnut Sign" Indicating Base Appendectomy in Device-Assisted Endoscopic Full-Thickness Resection.

Am J Gastroenterol 2019 Feb 1. Epub 2019 Feb 1.

Institute of Pathology Saarbrücken-Rastpfuhl, Saarbrücken, Germany.

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http://dx.doi.org/10.14309/ajg.0000000000000146DOI Listing
February 2019

Colonic Stool Burden a Useful Surrogate for Slow Transit Constipation as Determined by a Radiopaque Transit Study.

Am J Gastroenterol 2019 Feb 1. Epub 2019 Feb 1.

Center for Neurointestinal Health, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Objectives: Plain film abdominal x-ray (AXR) is frequently used in the evaluation of constipation, but studies assessing the association between stool burden on AXR and colonic transit have been limited. We sought to investigate the relationship between colonic stool burden and slow transit constipation, as determined by a radiopaque marker (ROM) transit study.

Methods: A retrospective cohort population was assembled, consisting of adult patients with chronic constipation who underwent testing with both a ROM study and anorectal manometry at 2 tertiary care centers over 5 years. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000149DOI Listing
February 2019

Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis: A Pilot Clinical Trial.

Am J Gastroenterol 2019 Jan 31. Epub 2019 Jan 31.

Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Background: Primary sclerosing cholangitis (PSC) is a cholestatic liver disease with no effective medical therapies. A perturbation of the gut microbiota has been described in association with PSC, and fecal microbiota transplantation (FMT) has been reported to restore the microbiome in other disease states. Accordingly, we aimed at evaluating the safety, change in liver enzymes, microbiota, and metabolomic profiles in patients with PSC after FMT. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000115DOI Listing
January 2019
1 Read

Sex Hormone-Binding Globulin Levels in Young Men Are Associated With Nonalcoholic Fatty Liver Disease in Midlife.

Am J Gastroenterol 2019 Feb 4. Epub 2019 Feb 4.

Division of Gastroenterology and Hepatology, University of California, San Francisco, California, USA.

Introduction: Cross-sectional data note lower levels of testosterone and sex hormone-binding globulin (SHBG) levels in men with nonalcoholic fatty liver disease (NAFLD). Whether sex hormone levels in young men are predictive of later risk of NAFLD is not known.

Methods: Among men in the prospective population-based multicenter Coronary Artery Risk Development in Young Adults study (mean age 50; n = 837), we assessed whether testosterone and SHBG levels measured at study year 10 (median age 35 years) were associated with prevalent NAFLD at study year 25. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000138DOI Listing
February 2019
2 Reads

Menopausal Hormone Therapy and Risk of Diverticulitis.

Am J Gastroenterol 2019 Feb;114(2):315-321

Division of Gastroenterology, University of Washington School of Medicine, Seattle, Washington, USA.

Introduction: Diverticulitis is a significant cause of morbidity among older women, and little attention has been paid to understanding its etiology. We have shown that menopausal hormone therapy (MHT) is associated with the risk of inflammatory bowel disease. In this study, we prospectively examined the association between MHT and the risk of incident diverticulitis. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000054DOI Listing
February 2019
1 Read

Continuing Medical Education Questions: February 2019.

Authors:
Ian Lustbader

Am J Gastroenterol 2019 Feb;114(2):200

New York University Langone Health, New York, New York.

To receive CME/MOC credit for this activity, please go to: http://acgjournalcme.gi.org/Article Title: Influence of Dietary Restriction on Irritable Bowel Syndrome. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000128DOI Listing
February 2019

Continuing Medical Education Questions: February 2019.

Am J Gastroenterol 2019 Feb;114(2):199

Center for Digestive and Liver Health, Savannah, GA.

To receive CME/MOC credit for this activity, please go to: http://acgjournalcme.gi.org/Article Title: Opportunities to Prevent Alcoholic Liver Cirrhosis in High-Risk Populations: A Systematic Review and Meta-Analysis. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000129DOI Listing
February 2019

In Memoriam: John Baillie, BSc (Hons), MB ChB, FRCP (Glasg), MACG, FASGE.

Authors:
Klaus Mergener

Am J Gastroenterol 2019 Feb;114(2):194-195

Washington Gastroenterology, Tacoma, Washington, USA.

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http://dx.doi.org/10.14309/ajg.0000000000000126DOI Listing
February 2019

Design of the Texas Hepatocellular Carcinoma Consortium Cohort Study.

Am J Gastroenterol 2019 Jan 23. Epub 2019 Jan 23.

Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine and Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA.

Objectives: The Texas Hepatocellular Carcinoma Consortium cohort study investigates risk factors of hepatocellular carcinoma (HCC) and biomarkers for early HCC detection in patients with liver cirrhosis.

Methods: Adult patients with liver cirrhosis are enrolled at 5 clinical centers from 3 cities in Texas, with a target of 5,000 patients. Clinical history, risk factor questionnaires, liver imaging, laboratory data, and blood samples were collected at enrollment and at each 6-month follow-up visit. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000068DOI Listing
January 2019
2 Reads

Response to Zhao et al.

Am J Gastroenterol 2019 Feb;114(2):358-359

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http://dx.doi.org/10.14309/ajg.0000000000000119DOI Listing
February 2019

Too Soon to Discard 5-ASAs?

Am J Gastroenterol 2019 Jan 23. Epub 2019 Jan 23.

Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.14309/ajg.0000000000000122DOI Listing
January 2019

Endoscopic Closure of Esophagopleural Fistula With AMPLATZER Atrial Septal Defect Closure Device.

Am J Gastroenterol 2019 Feb;114(2):198

Division of Gastroenterology and Hepatology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.

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http://dx.doi.org/10.14309/ajg.0000000000000125DOI Listing
February 2019

Is Fasting Necessary for Individuals With Nonalcoholic Fatty Liver Disease to Undergo Vibration-Controlled Transient Elastography?

Am J Gastroenterol 2019 Jan 23. Epub 2019 Jan 23.

Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Objectives: To investigate the effect of meal intake on liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) in patients with biopsy-proven nonalcoholic fatty liver disease undergoing vibration-controlled transient elastography.

Methods: LSM and CAP were assessed at baseline and serially for 6 hours after meal intake in 24 patients.

Results: A significant increase in LSM was seen up to the 2-hour time point (26 ± 25%, P = 0. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000116DOI Listing
January 2019

Outcomes in Patients With Cirrhosis on Primary Compared to Secondary Prophylaxis for Spontaneous Bacterial Peritonitis.

Am J Gastroenterol 2019 Jan 23. Epub 2019 Jan 23.

University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Objectives: Antibiotic prophylaxis is recommended for prevention of the first episode of spontaneous bacterial peritonitis (SBP; primary prophylaxis 1°) and subsequent episodes (secondary prophylaxis 2°). We aimed to compare outcomes in cirrhotic inpatients on 1° vs 2° SBP prophylaxis.

Methods: Data from North American Consortium for the Study of End-Stage Liver Disease were evaluated for cirrhosis details, reasons for admission/medications, inpatient course recorded, and outcomes over 90 days. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000044DOI Listing
January 2019
2 Reads

Patients' Perceptions of Proton Pump Inhibitor Risks and Attempts at Discontinuation: A National Survey.

Am J Gastroenterol 2019 Feb;114(2):244-249

Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.

Objectives: Little is known about how reports on the adverse effects of proton pump inhibitors (PPIs) impact patients' perceptions of these drugs and medication use. We sought to determine patients' level of concern about PPI adverse effects and its association with attempts to discontinue these drugs.

Methods: This study is an online survey of US adults who use PPIs for gastroesophageal reflux disease. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000061DOI Listing
February 2019
1 Read

Alcoholic and Nonalcoholic Fatty Liver Disease and Liver-Related Mortality: A Cohort Study.

Am J Gastroenterol 2019 Jan 23. Epub 2019 Jan 23.

Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, South Korea.

Objectives: We compared liver-related mortality by fibrosis severity between 2 types of fatty liver disease (FLD), nonalcoholic FLD (NAFLD) and alcoholic FLD (AFLD), in a large cohort of nonobese and obese individuals.

Methods: A cohort study was performed with 437,828 Korean adults who were followed up for up to 14 years. Steatosis was diagnosed based on ultrasonography; fibrosis severity was determined by the fibrosis 4 (FIB-4) score. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000074DOI Listing
January 2019

Increasing Trend in Young-Onset Colorectal Cancer in Asia: More Cancers in Men and More Rectal Cancers.

Am J Gastroenterol 2019 Feb;114(2):322-329

Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong.

Background: The incidence of young-onset colorectal cancer (CRC) is reported to be increasing in the Western world. There are no population-based studies assessing the trend across Asia.

Methods: We performed a multinational cohort study involving four Asian countries/regions, namely Taiwan, Korea, Japan, and Hong Kong. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000133DOI Listing
February 2019

An Approach to the Patient With Chronic Undiagnosed Abdominal Pain.

Am J Gastroenterol 2019 Jan 23. Epub 2019 Jan 23.

Division of Gastroenterology and the Medically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA.

Abdominal pain is a common reason for referral to a gastroenterologist. The workup of patients with chronic abdominal pain can be extremely challenging as clinicians are responsible for determining whether the patient can be observed or treated symptomatically or this abdominal pain heralds a more systemic disease. The differential is typically wide and given the innervation of the abdomen, localization of abdominal pain does not always provide clear insight into the etiology. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000130DOI Listing
January 2019
3 Reads

Histologic Healing Rates of Medical Therapies for Ulcerative Colitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Am J Gastroenterol 2019 Jan 25. Epub 2019 Jan 25.

Robarts Clinical Trials Inc., London, Ontario, Canada.

Objectives: Histologic remission is a potentially valuable means of assessing disease activity and treatment response in ulcerative colitis (UC). However, the efficacy of existing therapies to achieve this outcome is unclear. We performed a systematic review and meta-analysis of histologic outcomes in UC randomized controlled trials and examined the relationship between histologic and endoscopic outcomes. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000111DOI Listing
January 2019
6 Reads

Screening for Gastric Cancer.

Am J Gastroenterol 2019 Jan 18. Epub 2019 Jan 18.

Department of Biotechnology Chemistry & Pharmacy, Siena, Italy.

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http://dx.doi.org/10.14309/ajg.0000000000000110DOI Listing
January 2019
1 Read

Asymptomatic Macrocheilia in an Adult Woman.

Am J Gastroenterol 2019 Jan 18. Epub 2019 Jan 18.

Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.14309/ajg.0000000000000114DOI Listing
January 2019
1 Read
10.755 Impact Factor

Baveno-VI-Guided Prediction of Esogastric Varices in Primary Biliary Cholangitis.

Am J Gastroenterol 2019 Feb;114(2):361-362

French Reference Center for Inflammatory Biliary Diseases (MIVB) and French Network for Rare Liver Diseases (FILFOIE), Saint-Antoine Hospital, Paris, France.

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http://dx.doi.org/10.14309/ajg.0000000000000056DOI Listing
February 2019
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How I Approach It: Endoscopic Gallbladder Drainage.

Authors:
Douglas G Adler

Am J Gastroenterol 2019 Jan 18. Epub 2019 Jan 18.

Department of Internal Medicine, Division of Gastroenterology, University of Utah School of Medicine, Salt Lake City, Utah, USA.

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http://dx.doi.org/10.14309/ajg.0000000000000067DOI Listing
January 2019
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Corneal Transplantation From Donors With Hepatitis B: Preliminary Results.

Am J Gastroenterol 2019 Feb;114(2):362-364

Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

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http://dx.doi.org/10.14309/ajg.0000000000000052DOI Listing
February 2019
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10.755 Impact Factor

Inflammatory Bowel Disease and Risk of Erectile Dysfunction: What Does the Current Evidence Tell Us?

Am J Gastroenterol 2019 Feb;114(2):357-358

Department of Urology and Andrology, Minimally Invasive Surgery Center, Guangdong Provincial Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

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http://dx.doi.org/10.14309/ajg.0000000000000070DOI Listing
February 2019
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Proton Pump Inhibitor Use and Fracture Risk: An Update of Drug Safety Communication Needed?

Am J Gastroenterol 2019 Feb;114(2):360-361

Department of Orthopaedic Surgery, Saitama Medical University, Saitama, Japan.

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http://dx.doi.org/10.14309/ajg.0000000000000053DOI Listing
February 2019
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