36,626 results match your criteria The American journal of cardiology[Journal]


A Novel PITX2c Gain-of-Function Mutation, p.Met207Val, in Patients With Familial Atrial Fibrillation.

Am J Cardiol 2018 Dec 3. Epub 2018 Dec 3.

EA4612 Neurocardiologie, Université Lyon 1, Lyon, France. Electronic address:

Genome-wide studies have associated several genetic variants upstream of PITX2 on chromosome 4q25 with atrial fibrillation (AF), suggesting a potential role of PITX2 in AF. Our study aimed at identifying rare coding variants in PITX2 predisposing to AF. The Polymerase chain reaction sequencing of PITX2c was performed in 60 unrelated patients with idiopathic AF. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.047DOI Listing
December 2018

Comparison of Baseline Characteristics and In-hospital Outcomes in Medicaid Versus Private Insurance Hospitalizations for Atrial Fibrillation.

Am J Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Department of Internal Medicine, University of Nevada Reno School of Medicine, Reno, Nevada.

The prevalence of atrial fibrillation (Afib) has been increasing over the past few decades. There are very few comparisons of health insurance plans available that incorporate measurement of co-morbidities and in-hospital outcomes. We sought to compare an impact of Medicaid versus private insurance (PI) on outcomes in hospitalizations with Afib. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.045DOI Listing
December 2018

Coronary Artery Bypass Grafting Versus Percutaneous Coronary Intervention in Patients With Non-ST-Elevation Myocardial Infarction and Left Main or Multivessel Coronary Disease.

Am J Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Department of Cardiology, Hospital de Santa Cruz, Lisbon, Portugal.

Current recommendations on the optimal revascularization strategy in Non-ST-elevation myocardial infarction (NSTEMI) with left main (LM) or multivessel coronary disease (MVD) are based upon randomized clinical trials conducted in stable coronary artery disease. In a real-world contemporary observational registry, we compared the long-term outcome of NSTEMI patients with LM/MVD (n = 1,104) submitted to coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), or optimized medical therapy (OMT). The primary end point was 5-year all-cause mortality. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.052DOI Listing
December 2018

Usefulness of Failed Electrical Cardioversion for Early Recurrence After Catheter Ablation for Atrial Fibrillation as a Predictor of Future Recurrence.

Am J Cardiol 2018 Dec 4. Epub 2018 Dec 4.

Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan. Electronic address:

Early recurrence of atrial arrhythmia (ERAA) during a blanking period after catheter ablation (CA) for atrial fibrillation (AF) does not always result in subsequent AF recurrence. We investigated whether failed electrical cardioversion (ECV) during the blanking period was associated with recurrence. A total of 1,240 consecutive patients who underwent first-time CA for AF at our institution between March 2012 and March 2016 were investigated. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.039DOI Listing
December 2018

Effect of Sedentary Lifestyle on Cardiovascular Disease Risk Among Healthy Adults With Body Mass Indexes 18.5 to 29.9 kg/m.

Am J Cardiol 2018 Dec 4. Epub 2018 Dec 4.

Department of Community Health and Family Medicine, University of Florida, Gainesville, Florida.

A substantial proportion of adults at healthy body mass index (BMI) are potentially at high risk for cardiovascular disease (CVD). The objective of this study is to determine if sedentary lifestyle characteristics in healthy weight adults increase their likelihood of being at high CVD risk to that of individuals who are overweight. Adults aged 40 to 79 years in the 2011 to 2016 National Health and Nutrition Examination Survey at a healthy BMI (18. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.043DOI Listing
December 2018

Effect of Adaptive Servo-Ventilation on Periodic Limb Movements in Sleep in Patients With Heart Failure.

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.

Periodic limb movements in sleep (PLMS) are associated with adverse outcomes in patients with heart failure (HF). The aim of this study was to investigate whether PLMS change in response to adaptive servo-ventilation (ASV) for central sleep apnea (CSA) in patients with HF. We examined polysomnographic studies conducted between 2010 and 2014 at Mayo Clinic, Rochester, Minnesota (n = 14,444). Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.014DOI Listing
November 2018

Body Mass Index, Change in Weight, Body Weight Variability and Outcomes in Type 2 Diabetes Mellitus (from the ACCORD Trial).

Am J Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Heart and Vascular Center of Excellence, Wake Forest Baptist Health, Winston Salem, North Carolina. Electronic address:

Weight management is highly recommended to patients with diabetes mellitus. However, this prescription is often characterized by weight fluctuations. It remains unclear the effects of weight fluctuations on outcomes in diabetes mellitus. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.016DOI Listing
December 2018

Comparison of the Diagnostic Performance of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve in Patients With Versus Without Diabetes Mellitus (from the MACHINE Consortium).

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Department of Radiology & Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Cardiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Stanford University School of Medicine, Cardiovascular Institute, Stanford, California.

Coronary computed tomography angiography-derived fractional flow reserve (CT-FFR) is a noninvasive application to evaluate the hemodynamic impact of coronary artery disease by simulating invasively measured FFR based on CT data. CT-FFR is based on the assumption of a normal coronary microvascular response. We assessed the diagnostic performance of a machine-learning based application for on-site computation of CT-FFR in patients with and without diabetes mellitus with suspected coronary artery disease. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.024DOI Listing
November 2018

Glycated Hemoglobin and Outcomes of Heart Failure (from Get With the Guidelines-Heart Failure).

Am J Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Division of Cardiology, Ahmanson-UCLA Cardiomyopathy Center, University of California, Los Angeles, California. Electronic address:

Glycated hemoglobin (HbA) is a risk factor for new onset heart failure (HF). There is however a paucity of data evaluating its association with outcomes in patients with established HF. We assessed the relation of HbA with outcomes among hospitalized HF patients. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.023DOI Listing
December 2018

Patient-Reported Quality of Life as a Predictor of Mortality and Ventricular Tachyarrhythmia's During 7 Years' Follow-Up in Patients With an Implantable Cardioverter Defibrillator (from the MIDAS Study).

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Department of Psychology, University of Southern Denmark, Odense, Denmark; Department of Cardiology, Odense University Hospital, Odense, Denmark. Electronic address:

Preliminary evidence suggests that poor patient-reported quality of life (QoL) predicts mortality on the short term in patients with an implantable cardioverter defibrillator (ICD). It is unclear if this association persists on the long term. We evaluated whether patient-reported QoL at the time of implantation predicts mortality and ventricular tachyarrhythmias (VTa's) during 7 years' follow-up in patients with an ICD. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.021DOI Listing
November 2018

Bleeding and New-Onset Cancers in Patients With Atrial Fibrillation Receiving Nonvitamin K Antagonist Oral Anticoagulants.

Am J Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Whether bleeding should be considered a sufficient sign to justify thorough cancer surveillance in atrial fibrillation (AF) patients receiving nonvitamin K antagonist oral anticoagulants (NOACs) remains unclear. We investigated the relationships between bleeding events and new-onset cancers in AF patients receiving NOACs in a prospective cohort (n = 395, mean follow-up duration of 2.8 years). Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.046DOI Listing
December 2018
1 Read

Diagnostic and Prognostic Role of Cardiac Magnetic Resonance Before Implantable Cardioverter Defibrillator.

Am J Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Cardiology, Versilia Hospital, Lido di Camaiore, Italy.

The use of cardiac magnetic resonance (cMR) to assess remodeling and tissue characterization in primitive and secondary cardiomyopathies has progressively increased, and it carries important prognostic informations. The aim of this study was to assess the overall clinical value of cMR before implantable cardioverter defibrillator (ICD). All patients referred to our center for an ICD implantation and submitted to cMR (n = 134) were analyzed. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.036DOI Listing
December 2018
1 Read

Incidence and Outcomes of Acute Myocardial Infarction During Motor Vehicle Accident Related Hospitalizations.

Am J Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Division of Cardiovascular Disease, West Virginia University, Morgantown, West Virginia.

Data on Motor Vehicle Accidents (MVA) associated acute myocardial infarctions (AMI) are scares. We aimed to examine the frequency, characteristics, and outcomes of AMI among patients admitted with MVA. Patients hospitalized with Motor Vehicle Traffic Accidents (ICD-9-CM codes e810-e819) in 2003 to 2014 were identified in the national inpatient sample. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.050DOI Listing
December 2018
3 Reads

Cardiac Involvement by Yellow Fever(from the PROVAR+ Study).

Am J Cardiol 2018 Dec 4. Epub 2018 Dec 4.

Serviço de Cardiologia e Cirurgia Cardiovascular e Centro de Telessaúde do Hospital das Clínicas da UFMG, Belo Horizonte, Minas Gerais, Brazil; Departamento de Clínica Médica, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Incidence of Yellow Fever (YF) has increased in Brazil, and cardiac findings such as bradyarrhythmias and conduction abnormalities have been described. We aimed to perform a comprehensive cardiac evaluation of patients with YF, and to assess the association between cardiac involvement and disease severity. Patients hospitalized with YF from February to March 2018 underwent clinical and laboratory evaluation, focused bedside echocardiography (GE Vivid IQ), electrocardiogram and, in case of alterations, 24-hours Holter. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149183213
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http://dx.doi.org/10.1016/j.amjcard.2018.11.032DOI Listing
December 2018
1 Read

Comparison of In-Hospital Outcomes of Patients With-Versus-Without Ischemic Cardiomyopathy Undergoing Left Ventricular Assist Device Placement.

Am J Cardiol 2018 Nov 20. Epub 2018 Nov 20.

Department of Cardiovascular Medicine, Wayne State University, Detroit, Michigan.

The objective of this study was to evaluate the impact of heart failure (HF) etiology (ischemic cardiomyopathy [ICM] versus nonischemic cardiomyopathy) on in-hospital outcomes in patients undergoing left ventricular assist device (LVAD) placement using the Nationwide Inpatient Sample database. We identified patients who underwent LVAD placement from 2011 to 2014. The primary end point was the effect of ICM on in-hospital mortality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149183205
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http://dx.doi.org/10.1016/j.amjcard.2018.10.039DOI Listing
November 2018
2 Reads

Meta-Analysis Comparing the Incidence of Infective Endocarditis Following Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement.

Am J Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Department of Medicine Division of Cardiovascular Medicine, University of Iowa Hospitals and Clinics, Iowa, Iowa.

Infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) is a rare but life-threatening complication. Paravalvular regurgitation, compression of native leaflets, and space between transcatheter valve prosthesis and native valves could dispose TAVI recipients at increased risk of IE compared with SAVR. To assess the comparative risk of IE between TAVI and SAVR, we performed a systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.031DOI Listing
December 2018

Pre-hospital Transport Times and Outcomes After Different Reperfusion Strategies for ST-Elevation Myocardial Infarction.

Am J Cardiol 2018 Oct 21. Epub 2018 Oct 21.

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan.

This study evaluated prehospital transport times and clinical outcomes after different reperfusion strategies for ST-elevation myocardial infarction in a real-world setting. We consecutively enrolled 27,205 patients who underwent percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction in Michigan from 2010 to 2016. Primary PCI was performed in 25,927 patients (95%), whereas 1,278 (5%) were treated with a pharmacoinvasive strategy. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.10.015DOI Listing
October 2018

Impact of Subtended Myocardial Mass Assessed by Coronary Computed Tomographic Angiography-Based Myocardial Segmentation.

Am J Cardiol 2018 Dec 4. Epub 2018 Dec 4.

Department of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. Electronic address:

Although decision-making for revascularization is based on the extent of ischemic myocardium, the prognostic implication of supplying myocardial territories has not yet been studied. To evaluate the clinical impact of the coronary artery-based myocardial segmentation (CAMS)-derived myocardial volume subtended to the poststenotic segment, and to determine clinically relevant coronary lesions, coronary computed tomography angiography, invasive coronary angiography, and preprocedure fractional flow reserve (FFR) data were analyzed in 664 deferred lesions (in 577 patients) and 401 treated lesions (in 369 patients) with drug-eluting stent implantation, respectively. Using CAMS method, the myocardial volume subtended to a stenotic coronary segment (V) was assessed. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.042DOI Listing
December 2018

Recovery of Kidney Dysfunction After Transcatheter Aortic Valve Implantation (from the Northern New England Cardiovascular Disease Study Group).

Am J Cardiol 2018 Nov 6. Epub 2018 Nov 6.

Division of Cardiology, University of Vermont Larner College of Medicine, Burlington, Vermont.

Acute Kidney Recovery (AKR) is a potential benefit of transcatheter aortic valve implantation (TAVI). We determined the incidence and predictors of AKR in a multicenter prospective registry of TAVI. After excluding patients on dialysis or who died within 48 hours postprocedure, we reviewed 1,502 consecutive patients underwent TAVI in Northern New England from 2012 to 2017. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.10.042DOI Listing
November 2018

Usefulness of Cardiac Resynchronization Therapy in Patients With Continuous Flow Left Ventricular Assist Devices.

Am J Cardiol 2019 Jan 2;123(1):93-99. Epub 2018 Oct 2.

University of Iowa.

The benefit of cardiac resynchronization therapy in patients supported by a left ventricular assist device (LVAD) is unknown. There are currently no guidelines regarding the continuation, discontinuation or pacemaker (PM) settings post-LVAD implant. The aim of the study was to assess the hemodynamic benefit of biventricular (BiV) pacing in LVAD patients. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.09.022DOI Listing
January 2019
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Effect of Functional Mitral Regurgitation on Outcome in Patients Receiving Cardiac Resynchronization Therapy for Heart Failure.

Am J Cardiol 2019 Jan 26;123(1):75-83. Epub 2018 Sep 26.

Department of Cardiology, Heart Lung Center, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

Functional mitral regurgitation (FMR) is common in heart failure (HF), and negatively impacts prognosis. Cardiac resynchronization therapy (CRT) can improve FMR, but the long-term changes in and impact of FMR after CRT are still unclear. The present study investigated the prevalence, evolution and impact on mortality of FMR before and after CRT in patients with HF. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.09.020DOI Listing
January 2019

Meta-Analysis of Effects of Digoxin on Survival in Patients with Atrial Fibrillation or Heart Failure: An Update.

Am J Cardiol 2019 Jan 4;123(1):69-74. Epub 2018 Oct 4.

University Hospital Frankfurt, Goethe University, Frankfurt, Germany. Electronic address:

In 2015, 3 independent meta-analyses raised concerns about digoxin therapy being associated with an increased mortality risk in patients with atrial fibrillation (AF) and with heart failure (HF). Although several other studies have been published since then fostering these safety issues, the most recent 2016 European guidelines for AF still recommend this therapy as a class I indication. We performed an updated systematic review and random-effect meta-analysis on publications up to March 2018 reporting data on digoxin associated mortality in subjects with AF or HF. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149183185
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http://dx.doi.org/10.1016/j.amjcard.2018.09.036DOI Listing
January 2019
2 Reads

Comparison of In-Hospital Bleeding and Cardiovascular Events with High-Dose Bolus Tirofiban and Shortened Infusion to Short-Duration Eptifibatide as Adjunctive Therapy for Percutaneous Coronary Intervention.

Am J Cardiol 2019 Jan 26;123(1):44-49. Epub 2018 Sep 26.

Department of Pharmacy Services, Mayo Clinic, Rochester, Minnesota.

Potent platelet inhibition is one of the most important medical interventions to prevent ischemic complications during and after percutaneous coronary intervention (PCI). Practice has evolved with the introduction of potent oral P2Y inhibitors that provide quick, effective platelet inhibition, and the need for routine glycoprotein IIb/IIIa inhibitors (GPIs) has decreased. Additionally, a shorter duration of GPI infusion has been shown to be safe with adequate oral antiplatelet loading, but clinical outcome data are limited to eptifibatide. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149183185
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http://dx.doi.org/10.1016/j.amjcard.2018.09.029DOI Listing
January 2019
3 Reads

Relation of Length of Stay to Unplanned Readmissions for Patients Who Undergo Elective Percutaneous Coronary Intervention.

Am J Cardiol 2019 Jan 27;123(1):33-43. Epub 2018 Sep 27.

Keele Cardiovascular Research Group, Keele University, Stoke-on-Trent, United Kingdom; Royal Stoke University Hospital, Stoke-on-Trent, United Kingdom. Electronic address:

The cost of inpatient percutaneous coronary interventions (PCI) procedure is related to length of stay (LOS). It is unknown, how LOS may be associated with readmission rates and costs of index PCI and readmissions in elective PCI. This study aims to evaluate rates, predictors, causes, and costs associated with 30-day unplanned readmissions according to lLOS in patients, who underwent elective PCI. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.09.028DOI Listing
January 2019

Predictors, Burden, and the Impact of Arrhythmia on Patients Admitted for Acute Myocarditis.

Am J Cardiol 2019 Jan 27;123(1):139-144. Epub 2018 Sep 27.

Division of Cardiology, Wayne State University/Detroit Medical Center, Detroit, Michigan.

A significant proportion of patients with acute myocarditis experience sudden cardiac death presumably due to cardiac arrhythmia. In this study, we explore the burden, the predictors of arrhythmia in acute myocarditis and the association between arrhythmias and adverse in-hospital outcomes. After evaluating the frequency of various tachyarrhythmias and bradyarrhythmia in myocarditis population, we built a logistic model to determine the independent predictors of arrhythmias in myocarditis and a 1:1 propensity-matched analysis to examine the impact of arrhythmias. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.09.017DOI Listing
January 2019

Temporal Trends in Gender-Related Differences and Outcomes in Patients Who Underwent Transcatheter Aortic Valve Implantation (from the Israeli Transcatheter Aortic Valve Implantation Multicenter Registry).

Am J Cardiol 2019 Jan 3;123(1):108-115. Epub 2018 Oct 3.

Department of Cardiology, Rabin Medical Center, Petah Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

We evaluated temporal trends in gender-related differences in patients who underwent transcatheter aortic valve implantation (TAVI) for severe symptomatic aortic stenosis from a multicenter TAVI registry during the years 2008 to 2016. Our final cohort included 1,159 males and 1,370 females, with a median follow-up of 2.3 (IQR 1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149183183
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http://dx.doi.org/10.1016/j.amjcard.2018.09.018DOI Listing
January 2019
4 Reads

Comparison of One-Year Survival After Acute Coronary Syndrome in Patients ≥75 Years of Age With Versus Without Living With Spouse.

Am J Cardiol 2019 Jan 27;123(1):1-6. Epub 2018 Sep 27.

Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Patients with acute coronary syndrome (ACS) face high postevent mortality. This study aims to evaluate the impact of living without spouse on 1-year mortality of ACS patients. This retrospective study enrolled a total of 600 consecutive patients (≥75 years of age) with ACS hospitalized in our hospital between January 2013 and December 2016. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.09.032DOI Listing
January 2019
1 Read

Frequency of Takotsubo Cardiomyopathy in Adult Patients Receiving Chemotherapy (from a 5-Year Nationwide Inpatient Study).

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Department of Cardiology, Atlanta VA Medical Center, Decatur, Georgia; Department of Cardiology, Emory University School of Medicine, Atlanta, Georgia. Electronic address:

Takotsubo cardiomyopathy (TC) develops in patients who are under significant emotional, psychosocial, or sudden biochemical stress. However, the added burden of TC on the patients receiving chemotherapy has never been studied. We aimed to describe the additional clinical and economic burden, along with the potential predictors of TC and related in-hospital mortality in patients receiving chemotherapy using the largest inpatient cohort. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.006DOI Listing
November 2018

Prognostic Value of Combined C-Reactive Protein, Body Mass Index, and Left Ventricular Ejection Fraction in Predicting Cardiovascular Events in Patients ≥80 Years of Age With Acute Myocardial Infarction.

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Division of Dyslipidemia, State Key Laboratory of CardiovascularDisease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. Electronic address:

Elevated high-sensitivity C-reactive protein (hsCRP) and low body mass index (BMI) are linked to increased mortality in the elderly population. However, the combined value for predicting adverse cardiovascular events in the oldest-old (≥80 years old) with acute myocardial infarction (AMI) remains undetermined. A total of 463 AMI patients, who were ≥80 years old, were enrolled in this study between January 2012 and June 2017. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.025DOI Listing
November 2018
1 Read

Comparison of Outcomes and Frequency of Graft Failure With Use of Free Versus In Situ Internal Mammary Artery Bypass Conduits (from the PREVENT IV Trial).

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina. Electronic address:

Although in situ internal mammary artery (is-IMA) grafting remains the most frequent conduit in coronary artery bypass grafting (CABG), circumstances may necessitate free grafting of the IMA (f-IMA), though differences in outcomes have not been fully characterized. The purpose of this study was to compare clinical and angiographic outcomes of is-IMA versus f-IMA coronary bypass grafts in patients who underwent elective CABG surgery. In 1,829 patients in the angiographic cohort of PREVENT IV, 1,572 (85. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.029DOI Listing
November 2018

Relation of Body Mass Index to Risk of Death or Stroke in Patients Who Underwent Transcatheter Aortic Valve Implantation.

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Department of Cardiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.

Obesity and overweight have been associated with better clinical outcomes in different populations with a diverse spectrum of cardiovascular disease (obesity paradox). However, conflicting data exist about the relation between body mass index (BMI) and outcomes after transcatheter aortic valve implantation (TAVI). The aim of this study is to evaluate the association of body mass index with clinical outcomes in patients with severe aortic stenosis (AS) who underwent TAVI. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.015DOI Listing
November 2018

Prospective Evaluation for Hypoattenuated Leaflet Thickening Following Transcatheter Aortic Valve Implantation.

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Valve Science Center, Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital, Minneapolis, Minnesota. Electronic address:

Prospective investigations for the frequency of hypoattenuated leaflet thickening (HALT) and its clinical implications in transcatheter aortic valve implantation (TAVI) patients are limited. We initiated a prospective screening program of TAVI patients for HALT beginning in July 2015. Eligible patients were evaluated with gated, contrast-enhanced multidetector computed tomography within 30 days of TAVI, and examined for HALT and clinical outcomes. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.012DOI Listing
November 2018

Outcomes of Transcatheter Aortic Valve Implantation in Patients With Low Versus Intermediate to High Surgical Risk.

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

The Cardiology Department, Tel Aviv Sourasky Medical Center, Israel, affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Referral of low surgical risk (LSR) patients for transcatheter aortic valve implantation (TAVI) becomes common in multiple tertiary centers, and clinical trial data for this population are not available to date. We performed a retrospective analysis on an Israeli multicenter registry. LSR and intermediate-high surgical risk (I-HSR) were defined by a Society of Thoracic Surgery score of <4% and ≥4%, respectively. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.010DOI Listing
November 2018

Short-Term Effects of Dry Extracts of Artichokeand Berberis in Hypercholesterolemic Patients Without Cardiovascular Disease.

Am J Cardiol 2018 Nov 23. Epub 2018 Nov 23.

Department of Medical and Surgical Sciences, Alma Mater Studiorum - Università di Bologna, Bologna, Italy.

Hypercholesterolemia represents one of the main reversible cardiovascular risk factors. In this pilot clinical trial, we have tested the short-term efficacy and safety of a new combined cholesterol-lowering nutraceutical containing artichoke dry extract and berberine at enhanced bioavailability in subjects with moderate polygenic hypercholesterolemia in primary prevention for cardiovascular disease. After 2 months of treatment, the tested nutraceutical induced a significant reduction in plasma total cholesterol (-19%), low-density lipoprotein cholesterol (-16%), non-high-density lipoprotein cholesterol (-19%) and triglyceride levels (-15%), in association with a standardized control diet. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.018DOI Listing
November 2018

Prevention of Diabetes Mellitus in Patients With Prediabetes.

Am J Cardiol 2018 Nov 6. Epub 2018 Nov 6.

Department of Cardiovascular Sciences, Morsani College of Medicine, University of South Florida, Tampa, Florida.

Cardiovascular disease is a leading cause of death in patients with diabetes. Consequently, as antidiabetic medications have demonstrated cardiovascular benefit, cardiologists have been asked to weigh in regarding antidiabetic therapy. The cardiologist's role will continue to grow as antidiabetic agents with cardiovascular benefit are being studied in prediabetes as part of an evolving clinical environment. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.10.032DOI Listing
November 2018

Relation of Venous Thromboembolism Risk to Ischemic Stroke Risk in Hospitalized Patients with Cancer.

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Division of Cardiovascular Medicine, White River Junction VA Medical Center, White River Junction, Vermont; Department of Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire. Electronic address:

Patients with cancer are at increased risk for venous thromboembolism (VTE). However, the relationship of cancer type to the risk of arterial thrombosis in patients with high VTE risk has not been described. The goal of this study is to determine the rate of arterial thrombosis in patients with different types of solid tumors stratified by VTE risk. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.008DOI Listing
November 2018

Meta-Analysis of Prevalence and Short-Term Prognosis of Hemodynamically Unstable Patients With Symptomatic Acute Pulmonary Embolism.

Am J Cardiol 2018 Nov 26. Epub 2018 Nov 26.

Respiratory Department, Ramón y Cajal Hospital, Universidad de Alcalá (IRYCIS), Madrid, Spain. Electronic address:

There remains limited information about the prevalence and outcomes of hemodynamic unstable patients with acute pulmonary embolism (PE). We performed a systematic review and meta-analysis of prospective registries that enrolled patients with acute PE to assess the prevalence and prognostic significance of hemodynamic instability for the primary outcome of short-term all-cause mortality, and the secondary outcome of short-term PE-related mortality. We also assessed the association between use of thrombolytic therapy versus no use and short-term outcomes in the subgroup of unstable patients. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.009DOI Listing
November 2018
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Comparison of Local Versus General Anesthesia Following Transfemoral Transcatheter Self-Expanding Aortic Valve Implantation (from the Transcatheter Valve Therapeutics Registry).

Am J Cardiol 2018 Nov 6. Epub 2018 Nov 6.

The Valve and Structural Heart Disease Center, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

Transfemoral transcatheter aortic valve replacement (TF-TAVR) is mostly performed under general anesthesia (GA) in most US centers. We examined in-hospital and 30-day outcomes in patients who underwent TF-TAVR with a self-expanding bioprosthesis using local anesthesia (LA) or GA. Patients from the Transcatheter Valve Therapeutics Registry who underwent TF-TAVR from January 2014 to June 2016 with LA or GA were evaluated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149183205
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http://dx.doi.org/10.1016/j.amjcard.2018.10.041DOI Listing
November 2018
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Relation of the CHADS-VASc Score to Risk of Thrombotic and Embolic Stroke in Community-Dwelling Individuals Without Atrial Fibrillation (From The Atherosclerosis Risk in Communities [ARIC] Study).

Am J Cardiol 2018 Nov 6. Epub 2018 Nov 6.

Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota.

Recent hospital-based cohort studies found the CHADS-VASc score to be associated with ischemic stroke in individuals without atrial fibrillation (AF). Our aim was to determine the distribution of embolic and thrombotic strokes and association with the CHADS-VASc score, among community-dwelling individuals without AF. We included participants from the Atherosclerosis Risk in Communities (ARIC) Study who attended visit 4 (1996 to 1998) and had no previous AF, stroke, or anticoagulant use (n = 10,671). Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.10.037DOI Listing
November 2018
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Fallacies of Evidence-Based Medicine in Cardiovascular Medicine.

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Department of Cardiology, University Heart Center, University Hospital of Zurich, Zurich, Switzerland.

Evidence-based medicine (EBM) has gained a dominant role as the backbone of modern medical activities since its definition about 20 years ago. It serves the purpose to unify and optimize patient management and minimize scientific bias and fraud. The article looks, in the realm of cardiovascular medicine, at the banes of overly rigorous application of EBM with insufficient counterbalancing of other decision criteria. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.004DOI Listing
November 2018

Implications of Hyperuricemia in Severe Coronary Artery Disease.

Am J Cardiol 2018 Nov 23. Epub 2018 Nov 23.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. Electronic address:

Hyperuricemia has been associated with mortality in patients with coronary artery disease (CAD). However, its prognostic value remains unknown in the context of severe CAD with heavy atherosclerotic burden in all 3 vessels. We used data from a large cohort of consecutive patients with severe CAD. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.027DOI Listing
November 2018

Relation of Exercise Heart Rate Recovery to Predict Cardiometabolic Syndrome in Men.

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Preventive Cardiology and Cardiac Rehabilitation, Beaumont Health, Royal Oak, Michigan.

We examined the hypothesis that delayed heart rate recovery (HRR) after exercise testing, an estimate of decreased autonomic function, predicts the risk of cardiometabolic syndrome (MetS) and is associated with continuous MetS risk scores in healthy men. Participants were 2,740 men who underwent general health examinations and had no evidence of MetS, cardiovascular diseases, diabetes, and hypertension at baseline. Baseline HRR was calculated as the difference between peak heart rate attained during exercise testing and the heart rate at 1 (HRR 1) and 2 minutes (HRR 2) after test termination. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.017DOI Listing
November 2018
3.276 Impact Factor

Impact of Body Mass Index on Outcomes in the Edoxaban Versus Warfarin Therapy Groups in Patients Underwent Cardioversion of Atrial Fibrillation (from ENSURE-AF).

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

St. Vincenz-Hospital, Paderborn, Germany; Working Group: Molecular Electrophysiology, University Hospital Magdeburg, Magdeburg, Germany.

In the EdoxabaN versus warfarin in subjectS UndeRgoing cardiovErsion of Atrial Fibrillation study (NCT 02072434), edoxaban showed similar efficacy and safety versus enoxaparin-warfarin in patients underwent electrical cardioversion of nonvalvular atrial fibrillation. In this ancillary analysis, we compared the primary efficacy (composite of stroke, systemic embolic event, myocardial infarction, cardiovascular death, and overall study period) and safety (composite of major and clinically relevant nonmajor bleeding, on-treatment) end points in relation to body mass index (BMI; <30 vs ≥30 kg/m). We also compared cardioversion outcomes in relation to BMI. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.019DOI Listing
November 2018

Perioperative Bleeding in Patients With Acute Coronary Syndrome Treated With Fondaparinux Versus Low-Molecular-Weight Heparin Before Coronary Artery Bypass Grafting.

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Cardiac Surgery, Karolinska University Hospital, Stockholm, Sweden. Electronic address:

The perioperative bleeding risk in patients receiving fondaparinux versus low-molecular weight heparin before coronary artery bypass grafting has not been reported. We evaluated perioperative coronary artery bypass grafting-related bleeding in patients with acute coronary syndrome preoperatively treated with fondaparinux or low-molecular weight heparin. All patients with acute coronary syndrome from the prospective, European multicenter registry on coronary artery bypass grafting preoperatively treated with fondaparinux or low-molecular weight heparin undergoing isolated primary CABG were eligible. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.028DOI Listing
November 2018

Impact of Point-of-Care Platelet Function Testing Among Patients With and Without Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention With Drug-Eluting Stents (from the ADAPT-DES Study).

Am J Cardiol 2018 Nov 23. Epub 2018 Nov 23.

NewYork-Presbyterian/Columbia University Medical Center, New York, New York; Clinical Trials Center, Cardiovascular Research Foundation, New York, New York.

We sought to examine if the risk conferred by high on-treatment platelet reactivity (HPR) varies based upon clinical presentation. We examined the relation between HPR (P2Y12 reaction units >208) and adverse ischemic and bleeding events among patients with and without acute coronary syndromes (ACS) from ADAPT-DES; 51.7% of patients had ACS. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.026DOI Listing
November 2018

Usefulness of the Echocardiographic Calcium Score to Refine Risk of Major Adverse Cardiovascular Events Beyond the Traditional Framingham Risk Score.

Am J Cardiol 2018 Oct 19. Epub 2018 Oct 19.

Albert Einstein Medical Center, Division of Cardiology, Philadelphia, Pennsylvania.

Echocardiographic calcifications are associated with major adverse cardiovascular events (MACE). A recently described semiquantitative Global Cardiac Calcium Score (GCCS) has been associated with mortality and stroke, with increasing scores associated with increasing risk. This score assigns points for calcium in the aortic root and valve, mitral valve and annulus, and submitral apparatus, with additional points for restricted leaflet mobility. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.10.009DOI Listing
October 2018

Long-Term Outcome in Probable Versus Absolute Cardiac Sarcoidosis.

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Division of Cardiology, Heart and Lung Center, Helsinki University Central Hospital, and University of Helsinki, Helsinki, Finland.

Suspicion of cardiac sarcoidosis (CS) arises when a patient has clinical cardiac manifestations and findings on cardiac imaging suggestive of inflammatory cardiomyopathy with or without history of extracardiac sarcoidosis. The additional requirement for diagnosis is proof of sarcoidosis histology. Endomyocardial biopsy (EMB) showing granulomatous inflammation in absence of other explanations confirms an absolute diagnosis of CS while similar histology in an extracardiac biopsy gives a probable diagnosis of CS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149183208
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http://dx.doi.org/10.1016/j.amjcard.2018.11.007DOI Listing
November 2018
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Relation of Race, Apparent Disability, and Stroke Risk With Warfarin Prescribing for Atrial Fibrillation in Patients Receiving Maintenance Hemodialysis.

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Chronic Disease Research Group, Hennepin Healthcare Research Institute, Minneapolis, Minnesota.

Little is known about how warfarin is prescribed for stroke prevention in maintenance dialysis patients with chronic atrial fibrillation (AF). We examined patterns of warfarin use, and associated factors, after AF diagnosis. This retrospective cohort analysis studied US Medicare patients receiving maintenance dialysis January 1, 2008, to June 30, 2010. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.020DOI Listing
November 2018

Patient "Activation" of Patients Referred for Advanced Heart Failure Therapy.

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Abbott, Saint Paul, Minnesota.

Advanced heart failure (HF) is a devastating chronic illness requiring complex treatment regimens and patient engagement. Having the information, motivation, and skills to live with a medical condition are conceptualized by the term, "activation." Patients referred for advanced HF therapy and their unpaid family caregiver were invited to participate in this study by completing the 10-item patient activation measure (PAM) questionnaire. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.013DOI Listing
November 2018