36,742 results match your criteria The American journal of cardiology[Journal]


Gender Disparities in Management and Outcomes Following Transcatheter Aortic Valve Implantation With Newer Generation Transcatheter Valves.

Am J Cardiol 2019 Feb 10. Epub 2019 Feb 10.

Division of Cardiovascular Medicine, Department of Medicine, State University of New York at Stony Brook, Stony Brook, New York. Electronic address:

The impact of gender on management and early outcomes after transcatheter aortic valve implantation (TAVI) in the setting of newer generation transcatheter heart valves (THVs) is not well known. We evaluated gender-specific differences on clinical management and in-hospital outcomes in adults who underwent TAVI with newer generation THVs. The study population included 298 consecutive patients who underwent TAVI and received a newer generation THV (Sapien 3 [Edwards Lifesciences, Irvine, California] or Corevalve Evolut R or Evolut Pro [Medtronic, Minneapolis, Minnesota]) from December 2015 to June 2018 at an academic tertiary medical center. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.048DOI Listing
February 2019

The Added Value of Exercise Stress Echocardiography in Patients With Heart Failure.

Am J Cardiol 2019 Feb 10. Epub 2019 Feb 10.

Cardiac, Thoracic and Vascular Department, University of Pisa, Pisa, Italy.

Doppler echocardiography can provide reliable and repeatable measures of cardiac index (CI), whereas lung ultrasound (LUS) represents a quantitative approach to assess pulmonary congestion. We tested the hypothesis that simultaneous assessment of CI and LUS during exercise stress echocardiography (ESE) may define heart failure (HF) outpatients with different risk of adverse outcome. Standard transthoracic echocardiography and LUS (B-lines) evaluation were assessed during semisupine ESE. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.02.008DOI Listing
February 2019

Cardiovascular Outcomes of Patients With Pulmonary Hypertension Undergoing Noncardiac Surgery.

Am J Cardiol 2019 Feb 8. Epub 2019 Feb 8.

Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY; Department of Surgery, New York University School of Medicine, New York, NY.

Pulmonary hypertension (PH), defined by a mean pulmonary artery pressure of >25mm Hg at rest, is strongly associated with morbidity and mortality in the perioperative period. The prevalence and outcomes of PH among patients referred for major noncardiac surgery in the United States are unknown. Patients ≥18 years of age hospitalized for noncardiac surgery were identified from Healthcare Cost and Utilization Project's National Inpatient Sample data from 2004 to 2014. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.02.006DOI Listing
February 2019

In-Hospital Outcomes of Transcatheter Aortic Valve Implantation in Patients With Mitral Valve Stenosis.

Am J Cardiol 2019 Feb 8. Epub 2019 Feb 8.

Cleveland Clinic, Medicine Institute, Cleveland, Ohio.

Little is known about the outcome of patients with mitral stenosis (MS) who underwent transcatheter aortic valve implantation (TAVI). Therefore, we sought to evaluate the potential impact of MS on the outcome of patients who underwent TAVI using the US national cohort. Using weighted data from the National Inpatient Sample database between 2011 and 2015, we identified patients who had undergone a TAVI as a primary procedure. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.02.005DOI Listing
February 2019

Thoracoscopic Left Atrial Appendage Occlusion for Stroke Prevention Compared With Long-Term Warfarin Therapy in Patients With Nonvalvular Atrial Fibrillation.

Am J Cardiol 2019 Feb 10. Epub 2019 Feb 10.

McMaster University, David Braley Cardiac Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.amjcard.2019.02.003DOI Listing
February 2019

Outcomes Among Patients Transferred for Revascularization With Impella for Acute Myocardial Infarction With Cardiogenic Shock from the cVAD Registry.

Am J Cardiol 2019 Jan 25. Epub 2019 Jan 25.

Department of Cardiology, Henry Ford Hospital, Detroit, Michigan.

The outcomes for patients transferred with cardiogenic shock and later treated with revascularization and Impella support have not previously been studied. To evaluate these outcomes, patients in cardiogenic shock were recruited from the catheter-based ventricular assist device registry, a prospective registry enrolling patients who underwent percutaneous coronary intervention with hemodynamic support using Impella 2.5 or CP. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.029DOI Listing
January 2019

Comparison of the Transarterial and Transthoracic Approaches in Nontransfemoral Transcatheter Aortic Valve Implantation.

Am J Cardiol 2019 Feb 8. Epub 2019 Feb 8.

University of Rennes 1, Cardiac, Thoracic, and Vascular Surgery Department, Pontchaillou University Hospital, Signal and Image Treatment laboratory (LTSI), National Institute of Health and Medical Research U1099, Rennes, France.

Transfemoral approach stands as the reference access-route for transcatheter aortic valve implantation (TAVI). Nonetheless, alternatives approaches are still needed in a significant proportion of patients. This study aimed at comparing outcomes between transthoracic-approach (transapical or transaortic) and transarterial-approach (transcarotid or subclavian) TAVI. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.040DOI Listing
February 2019

Outcomes in Cardiogenic Shock from Acute Coronary Syndrome Depending on Severity of Obesity.

Am J Cardiol 2019 Jan 24. Epub 2019 Jan 24.

Department of Cardiology, John Ochsner Heart and Vascular Institute, New Orleans, Louisiana.

We reviewed 54,044 adult cases of cardiogenic shock (CS) accompanying acute coronary syndrome from the 2005 to 2014 Nationwide Inpatient Sample. We evaluated outcomes among patients who were nonobese, obese (body mass index 30.0 to 39. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.010DOI Listing
January 2019

Cardiovascular Events and Hospital Deaths Among Patients With Severe Sepsis.

Am J Cardiol 2019 Feb 7. Epub 2019 Feb 7.

Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama; Section of Cardiology, Birmingham Veterans Affairs Medical Center, Birmingham, Alabama. Electronic address:

The burden of cardiovascular events among patients hospitalized with severe sepsis and the association of these events with in-hospital mortality is not well known. We examined the incidence of cardiovascular events and their association with in-hospital mortality among patients with severe sepsis. Patients with severe sepsis from the New York State Inpatient Database from 2012 through 2014 were identified using a validated International Classification of Diseases 9th Revision, Clinical Modification code 995. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.038DOI Listing
February 2019

Electrocardiograms Recorded After Asystolic Cardiac Arrest.

Am J Cardiol 2019 Feb 8. Epub 2019 Feb 8.

Section of Cardiology, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana. Electronic address:

A man with a history of drug abuse was found down at home and was asystolic. Following restoration of sinus rhythm, a hypothermia protocol brought his temperature to 32.5°C (90. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.02.007DOI Listing
February 2019

Mechanisms of ST Elevation Myocardial Infarction in Patients Hospitalized for Noncardiac Conditions.

Am J Cardiol 2019 Feb 7. Epub 2019 Feb 7.

Division of Cardiology University of North Carolina, Chapel Hill, North Carolina; McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina. Electronic address:

ST elevation myocardial infarction (STEMI) occurring in patients hospitalized for a noncardiac condition is associated with a high mortality rate and thus we sought to determine the mechanisms underlying STEMI in this patient population. This is a single center retrospective study of 70 patients who had STEMI while hospitalized on a noncardiac service and underwent coronary angiography. Thrombotic in-hospital STEMI was defined by angiographic or intravascular imaging evidence of intracoronary thrombus, plaque rupture, or stent thrombosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149193016
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http://dx.doi.org/10.1016/j.amjcard.2019.01.039DOI Listing
February 2019
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Relationship Between Optimism and Outcomes in Patients With Chronic Angina Pectoris.

Am J Cardiol 2019 Feb 7. Epub 2019 Feb 7.

Department of Medicine, Duke University Medical Center, Durham, North Carolina; Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.

Greater optimism regarding recovery from chronic illness is associated with improved quality of life and clinical outcomes. We performed a post-hoc analysis on the association between optimism and outcomes in Ranolazine in Patients with Incomplete Revascularization after Percutaneous Coronary Intervention (RIVER-PCI), a randomized trial in patients with chronic angina pectoris who had incomplete revascularization following percutaneous coronary intervention. At baseline, patients answered how much they agreed with the phrase, "I am optimistic about my future and returning to a normal lifestyle. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.036DOI Listing
February 2019
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Angiographic and Midterm Thrombosis of Bioresorbable Vascular Scaffold for Coronary Bifurcation Narrowings.

Am J Cardiol 2019 Feb 7. Epub 2019 Feb 7.

Department of Cardiology, University of Patras School of Medicine, Patras, Greece.

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http://dx.doi.org/10.1016/j.amjcard.2019.02.001DOI Listing
February 2019

Sex Differences in Risk Factors for Incident Atrial Fibrillation (from the Reasons for Geographic and Racial Differences in Stroke [REGARDS] Study).

Am J Cardiol 2019 Feb 10. Epub 2019 Feb 10.

Department of Medicine, Section on Cardiology, Wake Forest School of Medicine, Winston-Salem, North Carolina; Epidemiological Cardiology Research Center (EPICARE), Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina. Electronic address:

We examined whether the sex differences in atrial fibrillation (AF) is related to difference in risk factors leading to AF or due to a differential impact of the same risk factors in 11,806 participants (55.2 % women) from the REGARDS study. Incident AF was ascertained by electrocardiograms and medical history at a follow-up examination. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.056DOI Listing
February 2019
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Prevalence of Diabetes Mellitus in Patients With Takotsubo Syndrome According to Age and Sex.

Authors:
John E Madias

Am J Cardiol 2019 Feb 7. Epub 2019 Feb 7.

Elmhurst Hospital Center, Elmhurst, New York.

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http://dx.doi.org/10.1016/j.amjcard.2019.02.002DOI Listing
February 2019

Invasive Hemodynamics and Outcomes in Cardiac Arrest Survivors Undergoing Targeted Temperature Management.

Am J Cardiol 2019 Jan 24. Epub 2019 Jan 24.

Cardiovascular Medicine Department, Cleveland Clinic, Cleveland, Ohio.

Most important prognostic factors in the postcardiac arrest patients who underwent targeted temperature management (TTM) derive from the periarrest period. Whether early invasive hemodynamics predict survival or neurologic outcomes remains unknown. We retrospectively reviewed all comatose survivors of cardiac arrest who underwent TTM at the Coronary Intensive Care Unit of a Quaternary Center between January 2015 and June 2017. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.016DOI Listing
January 2019

Effect of Perioperative Antiplatelet Therapy on Outcomes in Patients With Drug-Eluting Stents Undergoing Elective Noncardiac Surgery.

Am J Cardiol 2019 Feb 7. Epub 2019 Feb 7.

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Korea.

We investigated the association of perioperative antiplatelet therapy (APT) and outcomes in patients with drug-eluting stent (DES) placement for noncardiac surgery (NCS). In consecutive 23,358 patients who underwent percutaneous coronary interventions between 2005 and 2016, total of 2,179 patients that required 2,179 elective NCS after DES placement were retrospectively analyzed. A net adverse clinical event (NACE), composite of death, myocardial infarction, stent thrombosis, and major bleeding, was assessed at 30 days. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.02.004DOI Listing
February 2019
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Targeted Cancer Therapies With Pericardial Effusions Requiring Pericardiocentesis Focusing on Immune Checkpoint Inhibitors.

Am J Cardiol 2019 Jan 25. Epub 2019 Jan 25.

Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Case reports have reported immune checkpoint inhibitors (ICI), especially nivolumab, are associated with recurrent pericardial effusions. Our objective was to determine how often patients being treated with ICI develop hemodynamically significant pericardial effusion requiring pericardiocentesis compared with other cancer therapeutics and whether the survival of patients who underwent pericardiocentesis differs according to ICI use versus standard cancer therapeutics. Our institutional review board approved catheterization laboratory data collection for all pericardiocenteses performed and all patients receiving ICI from January 1, 2015 to December 31, 2017. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.013DOI Listing
January 2019
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Occurrence of Atrial Fibrillation During Dobutamine Stress Echocardiography.

Am J Cardiol 2019 Jan 31. Epub 2019 Jan 31.

Department of Cardiology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Centre de référence des cardiomyopathies et des troubles du rythme cardiaque héréditaires ou rares, Université de Versailles-Saint Quentin (UVSQ), Boulogne, France; INSERM U-1018, CESP, Team 5 (EpReC, Renal and Cardiovascular Epidemiology), UVSQ, Villejuif, France.

Dobutamine stress echocardiography (DSE) is a widely used examination for assessment of coronary ischemia, but several complications have been reported. The aim of this study was to assess the incidence of atrial fibrillation (AF) during DSE, and a systematic review and meta-analysis were also performed to determine an accurate estimate of the AF incidence. Over a 16-year period, we reviewed all patients referred for DSE. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.022DOI Listing
January 2019

Impact of Valve Replacement on Long-Term Survival in Asymptomatic Patients With Severe Aortic Stenosis.

Am J Cardiol 2019 Jan 25. Epub 2019 Jan 25.

Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Aortic valve (AV) replacement (AVR) is the only effective treatment for severe aortic stenosis (AS). However, survival benefits by performing AVR in asymptomatic AS patients with preserved left ventricular (LV) function remains controversial. This study included 468 patients (aged 64. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.035DOI Listing
January 2019
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Feasibility of Cardiac Magnetic Resonance Wideband Protocol in Patients With Implantable Cardioverter Defibrillators and Its Utility for Defining Scar.

Am J Cardiol 2019 Jan 31. Epub 2019 Jan 31.

University of Chicago Medical Center, Chicago, Illinois. Electronic address:

Implantable cardioverter defibrillators (ICDs) have been a relative contraindication to cardiovascular magnetic resonance imaging. Although cardiovascular magnetic resonance provides valuable information regarding scar in patients with ventricular arrhythmias or cardiomyopathy, ICDs in these patients frequently cause artifacts hindering accurate interpretation of both cine and late gadolinium enhancement (LGE) images. We sought to quantify the frequency and severity of artifact on LGE images and assess whether a modified wideband LGE protocol could improve the diagnostic yield of scar identification in agreement with invasive electroanatomic mapping (EAM). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149193011
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http://dx.doi.org/10.1016/j.amjcard.2019.01.018DOI Listing
January 2019
3 Reads

Patient Phenotypes, Cardiovascular Risk, and Ezetimibe Treatment in Patients After Acute Coronary Syndromes (from IMPROVE-IT).

Am J Cardiol 2019 Jan 25. Epub 2019 Jan 25.

Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina.

Risk prediction following acute coronary syndrome (ACS) remains challenging. Data-driven machine-learning algorithms can potentially identify patients at high risk of clinical events. The Improved Reduction of Outcomes: Vytorin Efficacy International Trial randomized 18,144 post-ACS patients to ezetimibe + simvastatin or placebo + simvastatin. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.034DOI Listing
January 2019
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Effects of Cangrelor as Adjunct Therapy to Percutaneous Coronary Intervention.

Am J Cardiol 2019 Jan 25. Epub 2019 Jan 25.

Division of Interventional Cardiology, MedStar Washington Hospital Center, Washington, District of Columbia. Electronic address:

Percutaneous coronary intervention (PCI) in patients with angiographic evidence of intracoronary thrombus is associated with in-hospital and 30-day adverse clinical outcomes. Cangrelor, a direct, rapid-onset acting intravenous P2Y receptor inhibitor, has been proved to be effective by reducing peri-PCI ischemic complications in subjects who underwent PCI. This study aimed to assess the angiographic and in-hospital clinical outcomes in all-comer patients receiving cangrelor immediately before PCI at a tertiary care center. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149193012
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http://dx.doi.org/10.1016/j.amjcard.2019.01.031DOI Listing
January 2019
8 Reads

American and European Hypertension Guidelines: Finding Common Ground.

Am J Cardiol 2019 Jan 25. Epub 2019 Jan 25.

University of Texas Southwestern Medical School Dallas, Texas; Apollo Institute for Blood Pressure Management, Apollo Hospitals and Apollo Medical College, Hyderabad, India; Faculty of Medicine and Health Sciences, Macquarie University Medical School, Sydney, Australia.

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http://dx.doi.org/10.1016/j.amjcard.2019.01.009DOI Listing
January 2019
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Simulation of the Impact of Statin Intolerance on the Need for Ezetimibe and/or Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor for Meeting Low-Density Lipoprotein Cholesterol Goals in a Population With Atherosclerotic Cardiovascular Disease.

Am J Cardiol 2019 Jan 25. Epub 2019 Jan 25.

Department of Medicine, Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, New York.

In a population with atherosclerotic cardiovascular disease, previous research indicated that approximately 86% can achieve low-density lipoprotein cholesterol (LDL-C) of <70 mg/dL with oral lipid-lowering therapies (LLT) only, whereas 14% would require a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. We aim to estimate these values accounting for varying levels of statin intolerance. A simulation model described previously was used to estimate the utilization of LLT needed to achieve LDL-C <70 mg/dL via an intensification algorithm which maximized statins before adding ezetimibe or a PCSK9 inhibitor. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.028DOI Listing
January 2019

Benefits and Risks of High-Intensity Interval Training in Patients With Coronary Artery Disease.

Am J Cardiol 2019 Jan 24. Epub 2019 Jan 24.

International Heart Institute, St. Patrick's Hospital, Missoula, Montana.

Exercise-based cardiac rehabilitation is integral to secondary prevention in patients with coronary artery disease. Recently, the effectiveness and "superiority" of high-intensity interval training (HIIT) is a purported time-saving alternative to "traditional" moderate-intensity continuous training (MICT) in cardiac rehabilitation. The rationale for HIIT adoption is, however, not fully substantiated in the scientific literature. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.008DOI Listing
January 2019

The Simulation Training in Coronary Angiography and Its Impact on Real Life Conduct in the Catheterization Laboratory.

Am J Cardiol 2019 Jan 24. Epub 2019 Jan 24.

Université de Lorraine, 54000, Nancy, France; Département de Cardiologie, Centre Hospitalier Universitaire Brabois, Nancy, France.

Our study aimed to evaluate the effectiveness of mentored simulation training (ST) in coronary angiography and to assess the transferability of acquired skills from virtual reality to the real world. Twenty cardiology residents were randomized to ST or control before performing real-life cases in the catheterization laboratory. The control group underwent secondary ST and reperformed real-life cases in the catheterization laboratory. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.032DOI Listing
January 2019
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Bleeding Risk of Add-On Anti-Platelet Agents to Direct Oral Anticoagulants in Patients With Nonvalvular Atrial Fibrillation (From 2216 Patients in the DIRECT Registry).

Am J Cardiol 2019 Jan 25. Epub 2019 Jan 25.

Department of Cardiology, Osaka Police Hospital, Osaka, Japan. Electronic address:

Clinical outcomes of the real-world Asian nonvalvular atrial fibrillation (NVAF) patients treated with DOAC and the incremental bleeding risk of add-on antiplatelet therapy to direct oral anticoagulants (DOACs) are still to be investigated. We conducted a single-center prospective observational registry of NVAF patients treated with DOACs: the DIRECT registry (UMIN000033283). All patients with NVAF (N = 2216) who were users of dabigatran (N = 648), rivaroxaban (N = 538), apixaban (N = 599), or edoxaban (N = 431) from June 2011 to November 2017 were enrolled (71. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.027DOI Listing
January 2019

A Prothrombotic State in Patients With a History of Left Ventricular Thrombus.

Am J Cardiol 2019 Jan 24. Epub 2019 Jan 24.

Institute of Cardiology, Jagiellonian University Medical College, Cracow, Poland; John Paul II Hospital, Cracow, Poland; Faculty of Medicine and Health Sciences, Jan Kochanowski University, Kielce, Poland. Electronic address:

Left ventricular thrombus (LVT) is associated with a hypercoagulable state and occurs most frequently after myocardial infarction (MI). Blood prothrombotic alterations might predispose to LVT formation, its recurrence, and subsequent cerebrovascular events. We investigated 58 patients with a history of LVT unrelated to recent MI or LV ejection fraction <25% and 58 well-matched control subjects. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.007DOI Listing
January 2019
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Usefulness of Left Ventricular Strain by Cardiac Magnetic Resonance Feature-Tracking to Predict Cardiovascular Events in Patients With and Without Heart Failure.

Am J Cardiol 2019 Jan 25. Epub 2019 Jan 25.

Perelman Center for Advanced Medicine, Philadelphia, Pennsylvania; Corporal Michael J. Crescenz VAMC, Philadelphia, Pennsylvania. Electronic address:

There is controversy regarding the utility of left ventricular (LV) mechanics assessed by feature-tracking steady-state free-precession (FT-SSFP), a readily implementable technique in clinical practice. In particular, whether LV mechanics assessed by FT-SSFP predicts outcomes in subjects with heart failure (HF) with reduced ejection fraction (HFrEF), with preserved ejection fraction (HFpEF), or without HF is unknown. We aimed to assess whether LV mechanics measured with FT-SSFP cine magnetic resonance imaging (MRI) predicts adverse outcomes. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.025DOI Listing
January 2019
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Contraceptive Choices in the Immediate Postpartum Period in Women With Cardiac Disease.

Am J Cardiol 2019 Jan 25. Epub 2019 Jan 25.

Department of Medicine, Division of Cardiology, University of California, San Francisco, California.

Maternal cardiac disease (MCD) is associated with increased maternal and neonatal morbidity and mortality. Because unplanned pregnancies are especially risky, active use of reliable contraception is critical in this population. Studies in the noncardiac population have demonstrated that the postpartum period is an ideal time to address contraceptive plans. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149193009
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http://dx.doi.org/10.1016/j.amjcard.2019.01.006DOI Listing
January 2019
4 Reads

Relation of Direct, Indirect, and Total bilirubin to Adverse Long-term Outcomes Among Patients With Acute Coronary Syndrome.

Am J Cardiol 2019 Jan 25. Epub 2019 Jan 25.

Department of Cardiovascular Medicine, the First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education, Xi'an, Shaanxi, China. Electronic address:

Bilirubin is known as an antioxidant. However, there have been controversies over whether bilirubin is protective against cardiovascular disease or not. In addition, no study has examined the association between subtypes of total bilirubin (direct bilirubin [DB] and indirect bilirubin [IDB]) and long-term outcomes of acute coronary syndrome (ACS) patients. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.019DOI Listing
January 2019
3 Reads

Usefulness of Ezetimibe Versus Evolocumab as Add-On Therapy for Secondary Prevention of Cardiovascular Events in Patients With Type 2 Diabetes Mellitus.

Am J Cardiol 2019 Jan 23. Epub 2019 Jan 23.

Diabetes Clinic, Central District, Maccabi Healthcare Services, Tel Aviv, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Evolocumab and ezetimibe, were both proven to significantly reduce the incidence of major adverse cardiovascular events (MACE), in type 2 diabetes patients with atherosclerotic cardiovascular disease and low-density lipoprotein (LDL) cholesterol >70 mg/dl despite statin therapy. Providing evolocumab for all such patients may be a significant burden on healthcare systems. Therefore, we analyzed the treatment cost of ezetimibe versus evolocumab to prevent 1 MACE. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149193011
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http://dx.doi.org/10.1016/j.amjcard.2019.01.021DOI Listing
January 2019
4 Reads

Conduction Delay-Induced J-Wave Augmentation in Patients With Coronary Heart Disease.

Am J Cardiol 2019 Jan 24. Epub 2019 Jan 24.

Department of Research and Development, Tachikawa Medical Center, Nagaoka, Japan. Electronic address:

Electrocardiogram records were surveyed for the presence of an atrial premature beat (APB) and J waves in patients with coronary heart disease and patients with noncardiac diseases. The prevalence and response of J waves to sudden shortening of the RR interval on the conducted APB were determined and compared between the 2 patients groups. The change in the QRS complexes on the APB was also determined. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.015DOI Listing
January 2019
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Predictive Factors for Progression of Mitral Regurgitation in Asymptomatic Patients With Mitral Valve Prolapse.

Am J Cardiol 2019 Jan 24. Epub 2019 Jan 24.

The Division of Cardiology, Department of Medicine, University of California, Sulpizio Cardiovascular Center, San Diego, California. Electronic address:

Risk factors predicting progression from low grade to severe mitral regurgitation (MR), which is a guideline criterion for surgical intervention, remain unknown. We hypothesized that abnormalities of cardiac structure and function may predict progression in MR severity. We followed 82 asymptomatic mitral valve prolapse (MVP) patients (65 ± 12 years, 51% men) with mild or moderate MR (36 mild, 46 moderate, mean LVEF: 62%), without significant co-morbidities. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.026DOI Listing
January 2019
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Thromboembolic Risk of Imaging-Confirmed Coronary Artery Disease Without Myocardial Infarction in Patients With Nonvalvular Atrial Fibrillation.

Am J Cardiol 2019 Jan 24. Epub 2019 Jan 24.

Department of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

The implication of coronary artery disease (CAD) without the clinical manifestation of myocardial infarction (non-MI-CAD) on thromboembolic events in patients with nonvalvular atrial fibrillation (NVAF) is not well evaluated. We hypothesized that non-MI-CAD would have a similar risk of future thromboembolism as MI-CAD. Clinical data for 17,073 consecutive patients (mean age, 64. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149193011
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http://dx.doi.org/10.1016/j.amjcard.2019.01.023DOI Listing
January 2019
5 Reads

Nonspecific Chest Pain and 30-Day Unplanned Readmissions in the United States (From the Nationwide Readmission Database).

Am J Cardiol 2019 Jan 25. Epub 2019 Jan 25.

Keele Cardiovascular Research Group, Institute for Science & Technology in Medicine, Keele University, Stoke-on-Trent, United Kingdom; Department of Cardiology, Royal Stoke University Hospital, Stoke-on-Trent, United Kingdom.

Chest pain is a common reason for admission to hospital and little is known regarding 30-day unplanned readmissions after an admission with a primary discharge diagnosis of nonspecific chest pain. We analyzed patients with a primary diagnosis of nonspecific chest pain in the Nationwide Readmission Database who were admitted in 2010 to 2014. Rates, causes, and predictors of 30-day unplanned readmissions were determined. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149193010
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http://dx.doi.org/10.1016/j.amjcard.2019.01.012DOI Listing
January 2019
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Effects of Congenital Heart Disease Treatmenton Quality of Life.

Am J Cardiol 2019 Jan 8. Epub 2019 Jan 8.

Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Technical University of Munich, Munich, Germany. Electronic address:

With rising survival rates of patients with congenital heart disease (CHD), functional health variables have become the key aspect in treatment evaluation. The effectiveness of various treatment options on the health-related quality of life (HRQoL) and the objectively measured exercise capacity as peak oxygen uptake (VO peak) remains rather unclear and hence, its investigation is the primary aim of this study. Data from 1014 patients (≥14-years-old, various CHD) were retrospectively reviewed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149193005
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http://dx.doi.org/10.1016/j.amjcard.2018.12.048DOI Listing
January 2019
2 Reads

Comparison of the Frequency of Thrombocytopenia After Transfemoral Transcatheter Aortic Valve Implantation Between Balloon-Expandable and Self-Expanding Valves.

Am J Cardiol 2019 Jan 4. Epub 2019 Jan 4.

Cardiology Department, Rangueil University Hospital, Toulouse, France. Electronic address:

Thrombocytopenia after transcatheter aortic valve implantation (TAVI) is common and has been related to worse clinical outcomes. Comparison of platelet kinetics among different types of valves is limited. Our objectives were to analyze the differences in drop platelet count (DPC) between balloon-expandable valves (BEVs) and self-expanding valves and their prognostic implications after TAVI. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.12.036DOI Listing
January 2019
6 Reads

Relation of Left Atrial Appendage Morphology Determined by Computed Tomography to Prior Stroke or to Increased Risk of Stroke in Patients With Atrial Fibrillation.

Am J Cardiol 2019 Jan 23. Epub 2019 Jan 23.

Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. Electronic address:

Left atrial appendage (LAA) morphology is considered to be associated with ischemic stroke, non-Chicken Wing LAA morphology increases the risk of thromboembolic events. However, existing classification of LAA morphology remains not well quantifiable and therefore may leave room for substantial subjective interpretation. This study aimed to assess interobserver and intraobserver agreements in LAA morphology and its real value in stroke prediction. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.024DOI Listing
January 2019

Risk Factors for Pulmonary Hypertension in Adults After Atrial Septal Defect Closure.

Am J Cardiol 2019 Jan 24. Epub 2019 Jan 24.

Department of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands. Electronic address:

Atrial septal defect (ASD) closure is performed to prevent pulmonary hypertension (PH), which is associated with poor outcome. This study investigated the prevalence of PH in adults before and after ASD closure and explored associations between patient characteristics and PH after ASD closure. Consecutive adult patients who underwent surgical or percutaneous ASD closure in the Erasmus MC, the Netherlands, were included (2000 to 2014). Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.011DOI Listing
January 2019
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Mycoplasma Pneumoniae Pericarditis.

Am J Cardiol 2019 Jan 24. Epub 2019 Jan 24.

Section of Cardiovascular Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut. Electronic address:

Mycoplasma pneumoniae is an atypical bacterium that is frequently implicated in respiratory infections, but uncommonly identified as a cause of pericarditis. We report 2 cases of pericarditis attributed to M. pneumoniae that were characterized by prolonged respiratory prodromes, pericardial, and pleural effusions, elevated inflammatory markers, and relapsing clinical courses. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.014DOI Listing
January 2019
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Impact of Mitral Stenosis on Survival in Patients Undergoing Isolated Transcatheter Aortic Valve Implantation.

Am J Cardiol 2019 Jan 25. Epub 2019 Jan 25.

Baylor University Medical Center, Baylor Heart and Vascular Hospital, Dallas, Texas. Electronic address:

This study was performed to investigate the prevalence and impact on survival of baseline mitral stenosis (MS) in patients who underwent transcatheter aortic valve implantation (TAVI) due to the presence of severe symptomatic aortic stenosis. This retrospective study included 928 consecutive patients with severe, symptomatic aortic stenosis who underwent TAVI in 2 institutions, from January 2012 to August 2016. Mean follow-up was 40. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.017DOI Listing
January 2019
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Trends in Utilization of Surgical and Transcatheter Mitral Valve Repair in the United States.

Am J Cardiol 2019 Jan 16. Epub 2019 Jan 16.

Division of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York; Cardiovascular Research Foundation, New York, New York.

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http://dx.doi.org/10.1016/j.amjcard.2019.01.005DOI Listing
January 2019
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Meta-analysis of Stroke and Bleeding Risk in Patients with Various Atrial Fibrillation Patterns Receiving Oral Anticoagulants.

Am J Cardiol 2018 Dec 19. Epub 2018 Dec 19.

Cardiovascular Department, The Second Affiliated Hospital of Nanchang University, Nanchang, China. Electronic address:

Oral anticoagulation therapy (OAT) is a mainstay for stroke prevention in atrial fibrillation (AF) patients. However, whether the risks of stroke/systemic embolic events (SEE) and bleeding events are affected by the type, duration, and frequency of AF in patients receiving OAT has been previously debated. We aimed to determine the risk of stroke/SEE and bleeding events associated with paroxysmal AF compared to persistent or permanent AF among patients who received OAT. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.055DOI Listing
December 2018

Relation of Admission Blood Pressure to In-hospital and 90-Day Outcomes in Patients Presenting With Transient Ischemic Attack.

Am J Cardiol 2019 Jan 11. Epub 2019 Jan 11.

Brigham and Women's Hospital Heart & Vascular Center and Harvard Medical School, Boston, Massachusetts.

The association between admission blood pressure (BP) and outcomes in patients with transient ischemic attack (TIA) is not well defined. Patients in the United States national Get With The Guidelines-Stroke registry with a TIA were included. Admission systolic and diastolic BP was used to compute mean arterial pressure and pulse pressure (PP). Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.12.037DOI Listing
January 2019
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3.276 Impact Factor

Serial 3-Dimensional Optical Coherence Tomography Assessment of Jailed Side-Branch by Second-Generation Drug-Eluting Absorbable Metal Scaffold (from the BIOSOLVE-II Trial).

Am J Cardiol 2019 Jan 4. Epub 2019 Jan 4.

Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, District of Columbia.

Second-generation drug-eluting absorbable metal scaffold (DREAMS 2G) is used for treating coronary lesions. However, the natural history of the jailed side-branch (SB) after DREAMS 2G implantation remains to be elucidated. The aim of this study is to investigate the effect of scaffold struts on jailed SBs as assessed by 3-dimensional (3D) optical coherence tomography (OCT) after implantation of DREAMS 2G. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.12.029DOI Listing
January 2019
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3.276 Impact Factor

Incidence, Predictors, Management, and Clinical Significance of New-Onset Atrial Fibrillation After Transcatheter Aortic Valve Implantation.

Am J Cardiol 2019 Jan 5. Epub 2019 Jan 5.

Department of Cardiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

There is limited information on the incidence, management, and prognostic impact of new-onset atrial fibrillation (NOAF) following transcatheter aortic valve implantation (TAVI) for severe aortic valve stenosis. In the prospective ASAN-TAVI registry, we evaluated a total of 347 consecutive patients who underwent TAVI from March 2010 to August 2017. The primary end point was a composite of stroke or systemic embolism at 12 months. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149193004
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http://dx.doi.org/10.1016/j.amjcard.2018.12.041DOI Listing
January 2019
5 Reads
3.276 Impact Factor

Achieving Guideline-Directed Heart Rate ControlEarly Posthospitalization.

Am J Cardiol 2019 Jan 4. Epub 2019 Jan 4.

Parkview Health, Fort Wayne, Indiana; Indiana University School of Medicine, Indianapolis, Indiana.

Guidelines for the treatment of heart failure (HF) recommend the titration of β blockers (BB) to a target dosage shown to be effective in clinical trials. The benefit of BBs is associated with heart rate (HR) control, with a target resting HR <70 bpm which in clinical trials have been associated with improved clinical outcomes. The primary purpose of this study was to gauge the ability to achieve guideline-directed medical therapy HR control in the early posthospitalization period for HF patients with the wearable cardioverter defibrillator (WCD), assessing whether the WCD could be used to evaluate HR both at rest and during activity to determine if targets were being met and to adequately direct clinical decision making. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.12.032DOI Listing
January 2019
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Meta-Analysis Comparing the Frequency of Target Lesion Revascularization with Drug-Coated Balloons or Second-Generation Drug-Eluting Stents for Coronary In-Stent Restenosis.

Am J Cardiol 2019 Jan 11. Epub 2019 Jan 11.

Department of Cardiology, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid, IIS-IP, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2019.01.004DOI Listing
January 2019
1 Read
3.276 Impact Factor