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Am J Dermatopathol 2019 Apr 10. Epub 2019 Apr 10.

Departments of Laboratory Medicine, and.

Galectin-3, a β-galactoside-binding lectin, has been implicated in vast repertoire of inflammatory and immunomodulatory processes including skin diseases. However, galectin-3 has not been comprehensively studied in infectious diseases. This study emphasizes on fascinating aspects of galectin-3 expression in dermal infection by studying post-kala-azar dermal leishmaniasis (PKDL), an intracellular infection caused by Leishmania donovani. Read More

Am J Dermatopathol 2019 Apr 11. Epub 2019 Apr 11.

Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada.

Am J Dermatopathol 2019 Apr 2. Epub 2019 Apr 2.

Department of Pathology, Loyola University Chicago, Maywood, IL.

Introduction: Cutaneous composite lymphoma (CCL) is extremely rare. When 2 potentially distinct lymphoid lesions occur at one skin site, distinguishing between one neoplastic clone and a secondary reactionary lymphoid response versus a second neoplasm is difficult. In this study, we describe a unique case of CCL along with a review of reported cases in literature to identify clues and discuss issues that are relevant to the diagnosis of CCL. Read More

Am J Dermatopathol 2019 Feb 22. Epub 2019 Feb 22.

Division of Dermatopathology, Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH.

Crospovidone, a polymer of poly N-vinyl-2-pyrrolidone, is an inert insoluble disintegrant found in pharmaceutical tablets. This material has been encountered in the lungs of intravenous drug users and embolized with other components such as talc and microcrystalline cellulose. More recently, crospovidone has also been described in the gastrointestinal tract. Read More

Am J Dermatopathol 2019 Mar 26. Epub 2019 Mar 26.

Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL.

Lichen sclerosus (LS) is a chronic inflammatory dermatosis that classically presents as sclerotic, atrophic plaques in the genital region. We present a case of acrochordon with histological features of LS, clinically mimicking intradermal nevus, in a 53-year-old man with no prior history of LS. Our case highlights an unusual morphologic variant of acrochordon and illustrates the role of chronic pressure and occlusion in the development of secondary features of LS. Read More

Am J Dermatopathol 2019 Mar 29. Epub 2019 Mar 29.

Department of Dermatology, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL.

Am J Dermatopathol 2019 Mar 29. Epub 2019 Mar 29.

Departments of Pathology, and.

A case of primary cutaneous anaplastic large cell lymphoma that was characterized by a striking clear cell appearance occurring in the thigh of a 38-year-old man is described. The tumor presented as a large ulcer with indurated borders and serosanguinous base measuring 9.0 × 4. Read More

Am J Dermatopathol 2019 Mar 29. Epub 2019 Mar 29.

Departments of Dermatology.

Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma, primary cutaneous CD30 lymphoproliferative disorders (pc CD30 LPD) being the second most prevalent. There is evidence that MF and pc CD30 LPD may coexist and share T-cell clonality, suggesting a common origin. These findings were supported by a T-cell receptor clonality assessment by the polymerase chain reaction coupled with capillary electrophoresis, although results produced by this method may be ambiguous. Read More

Am J Dermatopathol 2019 Mar 18. Epub 2019 Mar 18.

Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC.

Lichen planus (LP) is an idiopathic inflammatory disease of the skin, hair, nails, and mucous membranes. Classic cutaneous LP is characterized by violaceous flat-topped papules that typically favor the extremities. LP on the scalp, otherwise known as lichen planopilaris, classically presents with scarring alopecia, perifollicular erythema and follicular prominence. Read More

Am J Dermatopathol 2019 Apr 15. Epub 2019 Apr 15.

Department of Basic Science Education, Virginia Tech Carilion School of Medicine, Roanoke, VA.

Cutaneous endometriosis is an uncommon dermatologic disorder predominantly seen in young women. Most commonly, it presents within a region of a previous surgical scar, often in relation to a gynecologic procedure on the abdomen or in close proximity to the umbilicus. The typical clinical presentation is that of papules or nodules with monthly cyclical pain and size variation. Read More

Am J Dermatopathol 2019 Mar 20. Epub 2019 Mar 20.

Department of Pathology, Section of Dermatopathology, University of Virginia Health System, Charlottesville, VA.

Am J Dermatopathol 2019 Mar 20. Epub 2019 Mar 20.

Department of Dermatology, Fundación de Investigación Biomédica del Hospital Universitario de La Princesa, Madrid, Spain.

An atypical clinical variant of hand-foot-and-mouth disease (HFMD) with more extensive lesions and affecting adults has emerged during the past years, usually associated to the Coxsackievirus serotype A6 (CV-A6). We present a 19-year-old woman with a 3-day evolution eruption of papulovesicular lesions, which first appeared around the mouth and frontal area and rapidly spread. In addition, we present a 61-year-old man with a 4-day evolution asymptomatic eruption of papulovesicular lesions in both the hands and feet after suffering a cold 1 week before. Read More

Am J Dermatopathol 2019 Mar 20. Epub 2019 Mar 20.

Medical University of South Carolina, Charleston, SC.

Syringotropic mycosis fungoides (MF) is classified under folliculotropic MF. Although there is significant overlap between the 2, this study demonstrates that folliculotropism is frequently present in syringotropic MF, and when not present, the specimen did not include a follicle to examine. In addition, few of the pathology reports mentioned folliculotropism or syringotropism, although this is an important prognostic feature. Read More

Am J Dermatopathol 2019 Apr 1. Epub 2019 Apr 1.

Department of Dermatology, University of Wisconsin, Madison, WI.

Palisaded neutrophilic granulomatous dermatitis (PNGD) presents as skin-colored to erythematous papules symmetrically distributed on extensor extremities. Histologically, interstitial and/or palisaded granulomatous infiltrates are present with neutrophils and leukocytoclasis. Together with interstitial granulomatous dermatitis (IGD), PNGD is considered a reactive granulomatous dermatitis to a systemic trigger including connective tissue disease, infection, medication reaction, and less commonly malignancy. Read More

Am J Dermatopathol 2019 Apr 1. Epub 2019 Apr 1.

Saint Louis University, St. Louis, MO.

Am J Dermatopathol 2019 Mar 11. Epub 2019 Mar 11.

Dermatopatology Unit, San Gallicano Dermatological Institute IRCCS, Rome, Italy.

Am J Dermatopathol 2019 Mar 11. Epub 2019 Mar 11.

Delhi Dermpath Laboratory, Delhi Dermatology Group, New Delhi, India.

Am J Dermatopathol 2019 Mar 11. Epub 2019 Mar 11.

Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma, Barcelona, Spain.

Am J Dermatopathol 2019 Mar 11. Epub 2019 Mar 11.

Department of Pathology, Faculty of Medicine in Plzen, Charles University, Plzen, Czech Republic.

In our routine and consultative pathology practices, we have noticed that a relatively high proportion of spindle cell predominant trichodiscomas demonstrate a remarkable stromal admixture of adipose tissue, which along with spindle cells, prominent collagen bundles and myxoid change closely resembles spindle cell lipoma (SCL). To clarify their possible relationship to SCL, 25 cases of trichodiscoma and fibrofolliculoma with stromal "lipomatous metaplasia" were collected and examined using immunohistochemical stains [CD34 and retinoblastoma-1 (RB1) protein] and fluorescence in situ hybridization (RB1 deletion). The patients ranged in age from 35 to 81 years (median 64 years). Read More

Am J Dermatopathol 2019 Mar 15. Epub 2019 Mar 15.

Department of Dermatopathology, California Skin Institute, San Jose, CA.

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare primary cutaneous lymphoma preferentially localized in the subcutaneous adipose tissue and composed of cytotoxic T cells with an α/β immunophenotype. The neoplastic T cells can be variably admixed with other inflammatory cells, including histiocytes, which can rarely form noncaseating granulomas. We present a case of SPTCL in which granulomas are the predominant feature, composing 75%-80% of the inflammatory infiltrate. Read More

Am J Dermatopathol 2019 Mar 12. Epub 2019 Mar 12.

Dermatopathology Duisburg, Duisburg, Germany.

Am J Dermatopathol 2019 Apr;41(4):e35-e36

Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH.

Am J Dermatopathol 2019 Apr;41(4):314-315

Department of Dermatology, Kasr Al Aini Hospital, Cairo University, Cairo, Egypt.

Am J Dermatopathol 2019 Apr;41(4):312-313

Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH.

Am J Dermatopathol 2019 Apr;41(4):311

Division of Dermatology, Florida State University College of Medicine, Tallahassee, FL.

Am J Dermatopathol 2019 Apr;41(4):309-310

Ackerman Academy of Dermatopathology, New York, NY.

Am J Dermatopathol 2019 Mar 7. Epub 2019 Mar 7.

Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH.

Although classical neurofibromas are commonly encountered skin lesions, histologic variants are infrequent. We report a greater than 15-year retrospective review of a single institution's experience with the histopathologic diagnosis of neurofibroma of the female breast with a focus on the hyalinized variant. An electronic histopathology record review (CoPathPlus; Cerner Corp, North Kansas City, MO) was conducted from January 1, 2000, to October 16, 2015, for all "neurofibroma" diagnoses rendered in "females" at the anatomical site "breast". Read More

Am J Dermatopathol 2019 Mar 7. Epub 2019 Mar 7.

Harvard Medical School, Boston, MA.

Am J Dermatopathol 2019 Feb 25. Epub 2019 Feb 25.

Department of Dermatology, Venereology and Allergology, University Medical Centre, Göttingen, Germany.

AL-amyloidoma is considered to be a variant of primary cutaneous marginal zone lymphoma (pcMZL). A 51-year-old white man presented a 2 × 2-cm erythematous to brownish waxy plaque on the back of the scalp. The plaque was first noticed 16 years ago. Read More

Am J Dermatopathol 2019 Feb 26. Epub 2019 Feb 26.

Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA.

Immunoglobulin gamma (Ig) type 4-related disease (IgG4-RD) is a chronic immunologic systemic disorder that has gained worldwide recognition in the past decade. This entity can affect almost every organ system, and its characteristic lesions have been found in a variety of organs such as lacrimal and salivary glands, pancreas, liver, bile ducts, lungs, kidneys, retroperitoneum, breast, aorta, thyroid, and prostate. This case reports a very rare case of IgG4-RD presenting with a cutaneous lesion in a young female patient mimicking a lymphoproliferative disorder. Read More

Am J Dermatopathol 2019 Feb 26. Epub 2019 Feb 26.

CellCOM-SB Research Group Department, Institute for Biomedical Research of A Coruña (INIBIC), University of A Coruña (UDC), A Coruña, Spain.

Introduction: Benign cutaneous tumors with follicular differentiation are alleged to differentiate toward parts of the hair follicle. Connexin 43 (Cx43) is a gap junction protein, the tumoral role of which has been investigated in several types of tumors.

Objective: To study the pattern of expression of Cx43 in benign cutaneous tumors with follicular differentiation and to compare it with that shown by their alleged anatomical counterparts of the hair follicle. Read More

Am J Dermatopathol 2019 Feb 28. Epub 2019 Feb 28.

Department of Anatomical Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Perth, Western Australia, Australia.

Am J Dermatopathol 2019 Feb 27. Epub 2019 Feb 27.

Dermatology Unit, Galliera Hospital, Genoa, Italy.

Am J Dermatopathol 2019 Feb 28. Epub 2019 Feb 28.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Cutaneous mixed tumors, also known as chondroid syringomas, are benign adnexal neoplasms that share histomorphologic features with pleomorphic adenomas of the salivary gland. Recent work suggests that the similarity between these 2 tumor types extends to the molecular level because both harbor identical chromosomal rearrangements involving the PLAG1 gene. The resulting nuclear PLAG1 overexpression can be detected by immunohistochemistry and has become a useful diagnostic adjunct for both tumor types. Read More

Am J Dermatopathol 2019 Feb 28. Epub 2019 Feb 28.

Dermatopathology Section, Department of Pathology and Laboratory Medicine, VA Boston Healthcare System, MA.

In this report, we describe a case of a patient with a clinical history of systemic sarcoidosis and psoriasis who developed biopsy-confirmed perforating and necrotizing cutaneous granulomas after 12 months of treatment with adalimumab, a tumor necrosis factor-alpha-inhibiting, anti-inflammatory, biologic medication, prescribed for the patient's psoriasis. Although rare reports of a "sarcoidosis-like" reaction associated with select tumor necrosis factor-alpha agents exist, to the best of our knowledge, perforating and necrotizing cutaneous granulomas after treatment with adalimumab has not been previously reported. Given the patient's history of systemic sarcoidosis, the differential diagnosis includes reactivation of latent sarcoidosis with adalimumab as a trigger. Read More

Am J Dermatopathol 2019 Feb 28. Epub 2019 Feb 28.

Department of Pathology and Laboratory Medicine, Geisel School of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH.

Dermatitis herpetiformis is a rare, chronic autoimmune disorder characterized by intense pruritic papules and vesicles, which can be associated with celiac disease and other autoimmune disorders. Its histologic characteristic is the accumulation of neutrophils within the papillary dermis with granular deposition of immunoglobulin A (IgA) observed under direct immunofluorescence. Herein, we report a 58-year-old woman who presented with a vesicular rash on the buttocks. Read More

Am J Dermatopathol 2019 Feb 28. Epub 2019 Feb 28.

Departments of Pathology and.

Am J Dermatopathol 2019 Feb 28. Epub 2019 Feb 28.

Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH.

Primary systemic amyloidosis has a varied clinical presentation, making it one of the great masqueraders of other disease entities in clinical medicine. The association of amyloidosis with alopecia is uncommon with at least 22 cases reported in the literature mostly in the setting of systemic amyloidosis. Alopecia in these patients occurs either as the initial presentation of the systemic amyloidosis or it happens during the disease course. Read More

Am J Dermatopathol 2019 Feb 28. Epub 2019 Feb 28.

Departments of Pathology, and.

Background: Cell adhesion molecules are essential to lymphocyte migration in neoplastic and inflammatory skin diseases. Our aim was to investigate possible differences in cell adhesion molecule expression between mycosis fungoides (MF) and inflammatory skin diseases (drug reactions and allergic contact dermatitis).

Methods: We selected 33 biopsies from patients with MF and 10 biopsies of patients with inflammatory skin diseases from Department of Pathology-Universidade Federal de São Paulo (UNIFESP) from January 1997 to December 2013. Read More

Am J Dermatopathol 2018 Nov 8. Epub 2018 Nov 8.

Department of Pathology, Dermatopathology Section, The University of Texas MD Anderson Cancer Center, Houston, TX. Dr. Yildiz is now with the Department of Pathology, Bezmialem Vakif University, Istanbul, Turkey. Dr. Ronen is now with the Department of Pathology, Medical College of Wisconsin, Milwaukee, WI. Dr. Trinidad is now with the Department of Anatomic Pathology, University of Santo Tomas Hospital Benavides Cancer Institute, Manila, Philippines.

Am J Dermatopathol 2019 Mar;41(3):e26

Department of Dermatology, San Antonio Military Medical Center, San Antonio, TX.

Am J Dermatopathol 2019 Mar;41(3):239

National Hansen's Disease Programs, Healthcare Systems Bureau, Health Resources and Services Administration, U.S. Department of Health and Human Services, Baton Rouge, LA.

Am J Dermatopathol 2019 Mar;41(3):237-238

Dermatology Department, Complejo Hospitalario Universitario de Pontevedra, Pontevedra, Spain.

Am J Dermatopathol 2019 Mar;41(3):235-236

Department of Dermatology, San Antonio Military Medical Center, San Antonio, TX.

Am J Dermatopathol 2019 Mar;41(3):234

Department of Dermatology, Clinical University Hospital from Valencia, Valencia, Spain.

Am J Dermatopathol 2019 Mar;41(3):232-233

Department of Dermatology, SUNY Downstate Medical Center, Brooklyn, NY.

Am J Dermatopathol 2019 Mar;41(3):193-204

Autonomous Service Institute of Biomedicine, Caracas, Venezuela.

Keloids are defined histopathologically as an inflammatory disorder characterized by exhibiting numerous fibroblasts, abnormal vascularization, increased number of proinflammatory immune cells as well as uncontrolled cell proliferation, and exacerbated and disorganized deposition of extracellular matrix (ECM) molecules. Importantly, many of these ECM molecules display N- and O-linked glycan residues and are considered as potential targets for galectin-1 (Gal-1) and galectin-3 (Gal-3). Nevertheless, the presence and localization of Gal-1 and Gal-3 as well as the interactions with some of their binding partners in keloid tissues have not been considered. Read More

Am J Dermatopathol 2019 Mar;41(3):167-179

Associate Professor, Dermatopathology Section, Departments of Pathology and Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX.

The presence of multiple BAP1-negative melanocytic neoplasms is a hallmark of familial cancer susceptibility syndrome caused by germline mutations in BAP1. Melanocytic tumors lacking BAP1 expression may also present as sporadic lesions in patients lacking a germline BAP1 mutation. Here, we report histomorphologic and clinical characteristics of cutaneous melanomas with loss of BAP1 expression in 4 patients with no known history of BAP1-associated cancer susceptibility syndrome. Read More

Am J Dermatopathol 2019 Jan 29. Epub 2019 Jan 29.

Geisel School of Medicine at Dartmouth, Hanover, NH.

Spontaneous hair repigmentation of physiologically white or gray hair is a rare occurrence that may be associated with melanoma in elderly individuals. We present the first case of this phenomenon in a man. A gray-haired, 80-year-old man presented to dermatology clinic with a 3-cm lock of black hair on his vertex scalp that developed over 1 year. Read More

Am J Dermatopathol 2019 Jan 29. Epub 2019 Jan 29.

Pathology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.