336,551 results match your criteria Texas Heart Institute Journal[Journal]
Colloids Surf B Biointerfaces 2018 Nov 28;175:84-90. Epub 2018 Nov 28.
Dept. of Chemical Engineering, Texas A&M University, College Station, TX, 77843, USA. Electronic address:
Lectin hetero-multivalency, binding to two or more different types of ligands, has been demonstrated to play a role in case of both LecA (a Pseudomonas aeruginosa adhesin) and Cholera Toxin subunit B (a Vibrio cholerae toxin). In order to screen the ligand candidates that involve in hetero-multivalent binding from large molecular libraries, we present a turbidity-based emulsion agglutination (TEA) assay that can be conducted in a high-throughput format using the standard laboratory instruments and reagents. The benefit of this assay is that it relies on the use of emulsions that can be formed using ultrasonication, minimizing the bottleneck of substrate surface functionalization. Read More
Biol Blood Marrow Transplant 2018 Dec 3. Epub 2018 Dec 3.
Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Introduction: Pulmonary impairment predicts increased mortality in many settings, and respiratory viral infection (RVI) causes considerable morbidity and mortality in allogeneic hematopoietic cell transplant recipients (allo-HCT). We hypothesized that pulmonary impairment following respiratory viral infection, defined as a decline of forced expiratory volume in 1 second values by ≥10%, may identify allo-HCT recipients at high risk for mortality.
Methods: We studied all allo-HCT recipients at our institution who had RVI with respiratory syncytial virus, parainfluenza virus, or influenza from 2004-2013 and had pre-RVI and post-RVI pulmonary function tests. Read More
Behav Brain Res 2018 Dec 3. Epub 2018 Dec 3.
Department of Biology and Integrated Bioscience Program, The University of Akron, Akron, OH, 44325, United States; Department of Biological Sciences, University of Texas at El Paso, El Paso, 79968, United States.
This study tested the hypotheses that maternal and paternal effects differentially influence expression of their offspring's adult behavior and underlying neural mechanisms. We predicted that maternal influences would be greater than paternal influences on male offspring. We tested these hypotheses by cross-breeding two phenotypically-, behaviorally- and neuroanatomically-distinct populations of prairie voles (Microtus ochrogaster) from Illinois, which are highly prosocial, and Kansas, which are significantly less prosocial. Read More
Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.
Native Medicine and Marine Pharmacology Laboratory, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, Chennai 603 103, Tamil Nadu, India. Electronic address:
A low molecular weight posterior salivary gland (PSG) toxin was isolated and purified from the cuttlefish Sepia prashadi by Reverse Phase High Performance Liquid Chromatography (RP-HPLC). The protein and neutral sugar content of the PSG toxin was determined to be 1.033 mg/g and 282 μg/g. Read More
Surv Ophthalmol 2018 Dec 3. Epub 2018 Dec 3.
Associate Professor, Departments of Clinical Neurosciences and Surgery, University of Calgary.
A 45-year-old Caucasian woman presented with chronic bilateral, painless, progressive, peripheral vision loss. She was found to have bilateral optic atrophy and non-enhancing multifocal white matter lesions on magnetic resonance imaging of the brain. Cerebrospinal fluid analysis showed elevated myelin basic protein. Read More
Gastroenterology 2018 Dec 3. Epub 2018 Dec 3.
Department of Epidemiology and Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Background & Aims: Increasing rates of young-onset colorectal cancer (CRC) have attracted substantial research and media attention, but we know little about racial disparities among younger adults with CRC. We examined racial disparities in young-onset CRC by comparing CRC incidence and relative survival among younger (age <50 years) adults, in 2 time periods.
Methods: Using data from the Surveillance, Epidemiology, and End Results program of cancer registries, we estimated CRC incidence rates (per 100,000 persons ages 20 - 54 years) from 1992 through 2014, for different time periods (1992-1996 vs 2010-2014) and races (white vs black). Read More
Am J Obstet Gynecol 2018 Dec 3. Epub 2018 Dec 3.
Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Health Science Center at Houston, Houston, Texas.
Background: Inositols (INOs) supplementation during pregnancy, specifically the combination of myo-inositol (MI) and D-chiro-inositol (DCI), has been reported to improve vascular parameters in women with gestational diabetes mellitus. We demonstrated previously that offspring born to pregnant mice lacking endothelial nitric oxide synthase (eNOS+/-) gene have hypertension (HTN) as adults and when fed high fat diet (HFD) develop a metabolic syndrome (MS) phenotype.
Objective: Our aim was to evaluate if INOs treatment in pregnancy complicated by MS improves the vascular and metabolic profile in mice offspring programmed in utero to develop HTN and MS. Read More
Neuron 2018 Dec;100(5):1014-1016
Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA. Electronic address:
Mutations in the chromodomain helicase DNA-binding 2 (CHD2) gene have been found in patients with a range of neurodevelopmental disorders. In this issue of Neuron, Kim et al. (2018) showed that Chd2 haploinsufficiency compromises cortical development, synaptic function, and memory in mice. Read More
Br J Pharmacol 2018 Dec 6. Epub 2018 Dec 6.
Division of Hypothalamic Research, the University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.
Background And Purpose: Acute insulin administration results in a hyperpolarization and concomitant decrease of firing rate in a subpopulation of arcuate Proopiomelanocortin (POMC) and Neuropeptide Y/Agouti-related peptide (NPY/AgRP) cells. This rapid effect on cellular activity has been implicated as a cellular correlate of insulin effects on energy balance and glucose homeostasis. Recent evidence suggests that zinc in mammalian insulin formulations is required for the insulin-induced inhibition of arcuate POMC neurons, while guinea-pig insulin, which fails to bind zinc, activates POMC neurons in mice. Read More
PLoS Pathog 2018 Dec 6;14(12):e1007392. Epub 2018 Dec 6.
KU Leuven, Department of Microbiology and Immunology, Rega Institute, Laboratory of Evolutionary and Computational Virology, Leuven, Belgium.
Despite ongoing efforts to control transmission, rabies prevention remains a challenge in many developing countries, especially in rural areas of China where re-emerging rabies is under-reported due to a lack of sustained animal surveillance. By taking advantage of detailed genomic and epidemiological data for the re-emerging rabies outbreak in Yunnan Province, China, collected between 1999 and 2015, we reconstruct the demographic and dispersal history of domestic dog rabies virus (RABV) as well as the dynamics of dog-to-dog and dog-to-human transmission. Phylogeographic analyses reveal a lower diffusion coefficient than previously estimated for dog RABV dissemination in northern Africa. Read More
PLoS One 2018 6;13(12):e0208406. Epub 2018 Dec 6.
Department of Marine Biology, Texas A&M University at Galveston, Galveston, Texas, United States of America.
Sinking marine oil snow was found to be a major mechanism in the transport of spilled oil from the surface to the deep sea following the Deepwater Horizon (DwH) oil spill. Marine snow formation is primarily facilitated by extracellular polymeric substances (EPS), which are mainly composed of proteins and carbohydrates secreted by microorganisms. While numerous bacteria have been identified to degrade oil, there is a paucity of knowledge on bacteria that produce EPS in response to oil and Corexit exposure in the northern Gulf of Mexico (nGoM). Read More
PLoS One 2018 6;13(12):e0208427. Epub 2018 Dec 6.
Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas, United States of America.
Background: Type 2 diabetes is often linked with impaired proximal insulin signaling. Hence, a therapeutic agent that enhances cellular glucose uptake without requiring proximal insulin signaling would be desirable for improving glycemic control. The E4orf1 peptide (E4) derived from human adenovirus 36 (Ad36) promotes cellular glucose uptake in vitro and in vivo, independent of insulin. Read More
Aging Ment Health 2018 Dec 6:1-7. Epub 2018 Dec 6.
a Department of Pharmaceutical Systems and Policy , West Virginia University , Morgantown , WV , USA.
Background: Antipsychotic medication use among elderly with Alzheimer's disease and related dementias (ADRD) and without severe mental illness is considered as low-value care. Our objective was to assess the factors associated with this inappropriate use of antipsychotic medications among community-dwelling Medicare beneficiaries with ADRD and without severe mental illness.
Methods: This study used a retrospective cross-sectional design. Read More
Chem Res Toxicol 2018 Dec 6. Epub 2018 Dec 6.
Division of Environmental Health Sciences, School of Public Health , University of California , Berkeley , California 94720 , United States.
Evaluating carcinogenic mechanisms is a challenging part of hazard identification, as mechanistic data are both voluminous and diverse. An evaluation approach based on 10 key characteristics of human carcinogens provides a holistic and unbiased way to tackle this challenge. Read More
Cancer 2018 Dec 6. Epub 2018 Dec 6.
Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Background: The revised 2017 European LeukemiaNet (ELN) classification (ELN-2017) of acute myeloid leukemia (AML) divides patients into 3 prognostic risk categories, with additional factors such as the fms-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) allele ratio (AR) considered for risk stratification. To the best of the authors' knowledge, the prognostic usefulness of ELN-2017 in comparison with ELN-2010 in younger patients with AML has not been validated to date.
Methods: The authors performed a retrospective study on patients aged <60 years who received idarubicin plus cytarabine (IA)-based induction chemotherapy for newly diagnosed AML. Read More
Cancer 2018 Dec 6. Epub 2018 Dec 6.
Department of Radiation Oncology, Baylor College of Medicine, Houston, Texas.
Background: Patients with head and neck cancer (HNC) experience significant physical and psychological morbidity during radiotherapy (RT) that contributes to treatment interruptions and a poor quality of life. Although spouses/partners can help by encouraging patient self-management (eg, self-care) during RT, they often experience high psychological distress rates, lack basic health care knowledge and skills, and report increased marital conflict regarding patient self-management. The current pilot study examined the feasibility and acceptability of a 6-session telephone-based intervention called Spouses coping with the Head And neck Radiation Experience (SHARE), which teaches self-management, communication, and coping skills to patients with HNC and their spouses. Read More
Int J Cancer 2018 Dec 6. Epub 2018 Dec 6.
Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
The prevalence of Lynch syndrome (LS) varies significantly in different populations, suggesting that ethnic features might play an important role. We enrolled 3330 consecutive Chinese patients who had surgical resection for newly diagnosed colorectal cancer. Universal screening for LS was implemented, including immunohistochemistry for mismatch repair (MMR) proteins, BRAF mutation test and germline sequencing. Read More
Am J Epidemiol 2018 Dec 6. Epub 2018 Dec 6.
Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee.
Time between arrest of pregnancy development and miscarriage represents a window in which pregnancy is nonviable and not developing. In effect, the loss has happened and exposures cannot influence its fate. However, epidemiologic studies of miscarriage traditionally use gestational age at miscarriage to assign time in survival analyses, which overestimates duration of exposure and time at risk. Read More
JAMA Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.
Johns Hopkins Wilmer Eye Institute, Baltimore, Maryland.
Med Mycol 2018 Dec 6. Epub 2018 Dec 6.
Mycology Unit, Facultat de Medicina i Ciències de la Salut and IISPV, University Rovira i Virgili, Reus, Spain.
We report several cases of fungal infections in snakes associated with a new species within the genus Paranannizziopsis. Three juvenile Wagler's vipers (Tropidolaemus wagleri) presented with skin abnormalities or ulcerative dermatitis, and two snakes died. Histologic examination of skin from the living viper revealed hyperplastic, hyperkeratotic, and crusting epidermitis with intralesional fungal elements. Read More
J Crohns Colitis 2018 Dec 6. Epub 2018 Dec 6.
IBD Center, Department of Gastroenterology, Humanitas Research Hospital, Rozzano, Milan, Italy.
Intestinal fibrosis is an inevitable complication in patients with inflammatory bowel disease (IBD), occurring in its two major clinical manifestations: ulcerative colitis and Crohn's disease. Fibrosis represents the final outcome of the host reaction to persistent inflammation which triggers a prolonged wound healing response resulting in the excessive deposition of extracellular matrix, eventually leading to intestinal dysfunction. The process of epithelial-to-mesenchymal transition (EMT) represents an embryonic program relaunched during wound healing, fibrosis and cancer. Read More
JAMA Oncol 2018 Dec 6. Epub 2018 Dec 6.
Department of Medicine, Geffen School of Medicine at University of California Los Angeles, Los Angeles.
Importance: The 2013/2014 American Society of Clinical Oncology and College of American Pathologists (ASCO-CAP) guidelines for HER2 testing by fluorescence in situ hybridization (FISH) designated an "equivocal" category (average HER2 copies per tumor cell ≥4-6 with HER2/CEP17 ratio <2.0) to be resolved as negative or positive by assessments with alternative control probes. Approximately 4% to 12% of all invasive breast cancers are characterized as HER2-equivocal based on FISH. Read More
Med Care 2018 Dec 4. Epub 2018 Dec 4.
Department of Health Services Administration, University of Maryland School of Public Health, College Park, MD.
Background: Newborn care is one of the most frequent types of hospitalization and Medicaid covers over 50% of all births nationwide. However, little is known about regional variation in Medicaid newborn care spending and its drivers.
Objectives: To measure the contribution of market-level prices, utilization, and health risk on regional variation in spending among newborn Medicaid population in Texas. Read More
Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.
Department of Pathology, Stanford University School of Medicine, Stanford, CA.
The spectrum of tumors arising in the salivary glands is wide and has recently been shown to harbor a network of tumor-specific fusion genes. Acinic cell carcinoma (AciCC) is one of the more frequently encountered types of salivary gland carcinoma, but it has remained a genetic orphan until recently when a fusion between the HTN3 and MSANTD3 genes was described in one case. Neither of these 2 genes is known to be implicated in any other malignancy. Read More
Int Anesthesiol Clin 2019 ;57(1):144-162
Department of Anesthesiology and Pain Management, UT Southwestern Medical Center, Dallas, Texas.
Int Anesthesiol Clin 2019 ;57(1):131-143
Nuffield Department of Anaesthetics, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Int Anesthesiol Clin 2019 ;57(1):32-44
Department of Anesthesiology and Perioperative Medicine, VA Eastern Colorado Health Care System, Denver, Colorado.
Br J Psychiatry 2018 Dec 6:1-9. Epub 2018 Dec 6.
Clinical Senior Lecturer in Mood Disorders and Consultant Psychiatrist,National Affective Disorders Service; Academic Psychiatry Training Programme Lead,Institute of Psychiatry,Psychology and Neuroscience,King's College London,South London and Maudsley NHS Foundation Trust (SLaM); andCRN South London Lead for Mental Health,Centre for Affective Disorders, Institute of Psychiatry,Psychology and Neuroscience,King's College London,South London and Maudsley NHS Foundation Trust (SLaM),UK.
Background: Most people with bipolar disorder spend a significant percentage of their lifetime experiencing either subsyndromal depressive symptoms or major depressive episodes, which contribute greatly to the high levels of disability and mortality associated with the disorder. Despite the importance of bipolar depression, there are only a small number of recognised treatment options available. Consecutive treatment failures can quickly exhaust these options leading to treatment-resistant bipolar depression (TRBD). Read More
Personal Disord 2018 Dec 6. Epub 2018 Dec 6.
Department of Psychiatry, University of California, San Diego.
Psychopathy has long been conceptualized in terms of an absence of emotion. Yet, recent studies have suggested that the experience of other-directed negative emotions may be more intimately linked to psychopathy than previously acknowledged, although there is limited knowledge concerning the experience of such emotions. The present study examined the disposition to experience two other-directed emotions, spitefulness and contempt, that are conceptually linked with psychopathy but currently are limited in empirical support. Read More
Hum Mutat 2018 Dec 6. Epub 2018 Dec 6.
Genome Research Division, Human Genetics department, Radboud University Medical Center Nijmegen and Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.
Next-generation sequencing has been instrumental in solving the genetic basis of rare inherited diseases, especially neurodevelopmental syndromes. However, functional workup is essential for precise phenotype definition and to understand the underlying disease mechanisms. Using whole exome and whole genome sequencing in 4 independent families with hypotonia, neurodevelopmental delay, facial dysmorphism, loss of white matter and thinning of the corpus callosum, we identified 4 previously unreported homozygous truncating PPP1R21 alleles: c. Read More
Endocr Metab Immune Disord Drug Targets 2018 Dec 6. Epub 2018 Dec 6.
Laboratorio de Hígado, Páncreas y Motilidad (HIPAM) - Unidad de Investigación en Medicina Experimental, Facultad de Medicina, UNAM. Mexico.
Background: Natural killer cells (NKC) are a major component of innate immune response to HCV, mediating their effects through TRAIL and IFN-γ. However, their function is diminished in chronic HCV patients (HCVp). Prolactin is an immunomodulatory hormone capable of activating NKC. Read More
Pharmacogenomics 2018 Dec 6. Epub 2018 Dec 6.
Department of Psychiatry & Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.
Aim: To conducted a systematic review and meta-analysis of prospective, randomized controlled trials (RCTs) that examined pharmacogenetic-guided decision support tools (DSTs) relevant to depressive symptom remission in major depressive disorder (MDD).
Patients & Methods: Random-effects meta-analysis was performed on RCTs that examined the effect of DSTs on remission rates in MDD. RCT quality was assessed using the Cochrane Collaboration Criteria. Read More
J Biomed Opt 2018 Dec;23(12):1-4
California Institute of Technology, Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Depa, United States.
Photoacoustic endoscopy offers in vivo examination of the visceral tissue using endogenous contrast, but its typical B-scan rate is ∼10 Hz, restricted by the speed of the scanning unit and the laser pulse repetition rate. Here, we present a transvaginal fast-scanning optical-resolution photoacoustic endoscope with a 250-Hz B-scan rate over a 3-mm scanning range. Using this modality, we not only illustrated the morphological differences of vasculatures among the human ectocervix, uterine body, and sublingual mucosa but also showed the longitudinal and cross-sectional differences of cervical vasculatures in pregnant women. Read More
Diabetes Obes Metab 2018 Dec 6. Epub 2018 Dec 6.
University of Perugia School of Medicine, Perugia, Italy.
Aims: To identify factors associated with achievement of glycated haemoglobin A1c (HbA1c) target at 24 weeks after commencing basal insulin therapy in people with type 2 diabetes mellitus (T2DM).
Materials And Methods: Post-hoc pooled analysis of 16 randomised, treat-to-target trials involving people with T2DM inadequately controlled on oral anti-hyperglycaemic drugs (n=3415) initiated on once-daily insulin glargine 100 U/mL (Gla-100). Clinical outcomes were assessed by HbA1c response at 24 weeks and people classified as "good responders" by reaching HbA1c <7. Read More
Chembiochem 2018 Dec 5. Epub 2018 Dec 5.
University of Texas at Austin, Chemistry, 105 E 24th St Stop A5300, 78712, Austin, UNITED STATES.
One-third of all proteins are estimated to require metals for structural stability and/or catalytic activity. Desthiobiotin probes containing metal binding groups can be used to capture metalloproteins with exposed active-site metals under mild conditions to prevent changes in metallation state. The proof-of-concept was demonstrated with carbonic anhydrase (CA), an open active site, Zn-containing protein. Read More
Pacing Clin Electrophysiol 2018 Dec 5. Epub 2018 Dec 5.
Department of Pediatrics, Baylor College of Medicine, Houston, TX.
Health Serv Res 2018 Dec 5. Epub 2018 Dec 5.
Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
Objective: To determine the reliability of the Social Security Death Master File (DMF) after the November 2011 changes limiting the inclusion of state records.
Data Sources: Secondary data from the DMF, New York State (NYS) and New Jersey (NJ) Vital Statistics (VS), and institutional data warehouse.
Study Design: Retrospective study. Read More
Int J Hematol 2018 Dec 5. Epub 2018 Dec 5.
Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Dig Dis Sci 2018 Dec 5. Epub 2018 Dec 5.
Department of Gastroenterology, New York Medical College, Valhalla, NY, 10595, USA.
Background: Gastrointestinal hemorrhage (GIH) is reported to occur in 1-8% of patients admitted with acute ischemic stroke (AIS). AIS is considered to be a relative contraindication to GIE.
Aims: Evaluate the outcomes of gastrointestinal endoscopy (GIE) in patients hospitalized with AIS and GIH. Read More
Neurocrit Care 2018 Dec 5. Epub 2018 Dec 5.
University Health System, San Antonio, TX, USA.
Background/objectives: Deep vein thrombosis (DVT) and pulmonary embolism (PE) are complications of hospitalization leading to increased morbidity and mortality. Routine surveillance ultrasound has become common practice in some intensive care units (ICU) to detect DVT early and initiate anticoagulation, preventing complications. However, initiating anticoagulants for asymptomatic DVT treatment may increase risk of hemorrhage. Read More
Ann Surg Oncol 2018 Dec 5. Epub 2018 Dec 5.
The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Natl Conf Comput Vis Pattern Recognit Image Process Graph 2018 26;841:232-244. Epub 2018 Apr 26.
University of Texas at Austin, Austin TX 78705, USA.
Most hyperspectral images (HSI) have important spectral features in specific combination of wave numbers or channels. Noise in these specific channels or bands can easily overwhelm these relevant spectral features. Maximum Noise Fraction (MNF) by Green . Read More
Heliyon 2018 Nov 27;4(11):e00965. Epub 2018 Nov 27.
Office of Information Technology, University of Texas at Arlington, P.O.B 19407, Arlington, Texas, 76019, USA.
Background: Adolescent childbirth continues as a public health concern, and investigation of postpartum posttraumatic stress symptoms (PTSS) and depression is important to inform future research and practice. Longitudinal studies exploring PTSS alone or in combination with depression are non-existent for postpartum adolescent populations. This study aimed to identify stress/PTSS and depression symptoms at 72 hours and three, six, and nine months postpartum, and determine if symptoms at each time point predicted later symptoms. Read More
Gynecol Oncol Rep 2019 Feb 16;27:1-4. Epub 2018 Nov 16.
Department of Gynecologic Oncology and Reproductive Medicine, University of Texas, M.D. Anderson Cancer Center, Houston, TX, United States.
Objective: Up to 87% of uterine leiomyosarcomas have estrogen receptor positivity. There are no effective adjuvant therapies for LMS. The objective of this study was to determine the efficacy of letrozole in patients with newly diagnosed uterine leiomyosarcoma (uLMS). Read More
Hypoxia (Auckl) 2018 8;6:35-56. Epub 2018 Nov 8.
Department of Anesthesiology and Pain Management, University of Texas Southwestern, Dallas, TX, USA,
Background: The brain is extensively vascularized, useŝ20% of the body's oxygen, and is highly sensitive to changes in oxygen. While synaptic plasticity and memory are impaired in healthy individuals by exposure to mild hypoxia, aged individuals appear to be even more sensitive. Aging is associated with progressive failure in pulmonary and cardiovascular systems, exposing the aged to both chronic and superimposed acute hypoxia. Read More
Ecol Evol 2018 Nov 23;8(22):10879-10892. Epub 2018 Oct 23.
United States Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center Fort Collins Colorado.
Understanding factors that influence observation processes is critical for accurate assessment of underlying ecological processes. When indirect methods of detection, such as environmental DNA, are used to determine species presence, additional levels of uncertainty from observation processes need to be accounted for. We conducted a field trial to evaluate observation processes of a terrestrial invasive species (wild pigs- ) from DNA in water bodies. Read More
J Clin Aesthet Dermatol 2018 Oct 1;11(10):24-28. Epub 2018 Oct 1.
Drs. Stephens and Babcock are with Thomas J. Stephens and Associates, Inc. in Colorado Springs, Colorado.
The gold standard for the treatment of hyperpigmentation is hydroquinone (HQ), which has been available as a skin lightener for more than 50 years. Numerous clinical studies have proven its efficacy in various topical formulations. In the United States, HQ is available as a nonprescription product in 2% formulations and as a 4% prescription product. Read More