13,089 results match your criteria Tetralogy of Fallot

Pediatric Surgical Pulmonary Valve Replacement Outcomes After Implementation of a Clinical Pathway.

World J Pediatr Congenit Heart Surg 2022 Jul;13(4):420-425

Department of Pediatrics, Division of Cardiology, 23333Loma Linda University Children's Hospital, Loma Linda, CA, USA.

Background: Standardization of perioperative care can reduce resource utilization while improving patient outcomes. We sought to describe our outcomes after the implementation of a perioperative clinical pathway for pediatric patients undergoing elective surgical pulmonary valve replacement and compare these results to previously published national benchmarks.

Methods: A retrospective single-center descriptive study was conducted of all pediatric patients who underwent surgical pulmonary valve replacement from 2017 through 2020, after the implementation of a clinical pathway. Read More

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Technique for Neo-Pulmonary Valve Creation With Living Tissue for Repair of Atrioventricular Septal Defect and Tetralogy of Fallot.

World J Pediatr Congenit Heart Surg 2022 Jul;13(4):499-502

Department of Surgery, Division of Cardiothoracic Surgery, Section of Pediatric Cardiothoracic Surgery, 12275Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, Missouri, USA.

Long-standing effects of pulmonary regurgitation after transannular patch repair in Tetralogy of Fallot (ToF) can be especially deleterious in the setting of combined ToF and complete atrioventricular septal defect (CAVSD). We present a technique for a complete repair of combined ToF/CAVSD using right atrial appendage tissue to create a competent neo-pulmonary valve. This technique provides advantages of right heart protection via pulmonary valve competence and the use of living tissue capable of growth with the patient, potentially obviating the need for repeat interventions. Read More

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Long-Term Results after Fallot Repair.

Thorac Cardiovasc Surg 2022 Dec 25;70(S 03):e7-e14. Epub 2022 Jun 25.

Universitäts-Kinderspital Zürich, Zurich, Switzerland.

Background:  The aim of this study was to evaluate the long-term outcome and freedom from pulmonary valve replacement (PVR) after initial repair of tetralogy of Fallot (TOF).

Patients And Methods:  The cohort of 306 patients treated between 1980 and 2017 was divided into anatomical subgroups according to the diagnosis of TOF-pulmonary stenosis, TOF-pulmonary atresia and TOF-double outlet right ventricle. Patients were treated with transannular patch (TAP), valve sparing repair (VSR), or conduits from the right ventricle to the pulmonary arteries (RVPA conduits). Read More

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December 2022

Methotrexate for management of twin pregnancy with complete hydatidiform mole and co-existing live fetus: A case report.

Int J Surg Case Rep 2022 Jun 18;96:107320. Epub 2022 Jun 18.

Faculty of Medicine, Damascus University, Damascus, Syrian Arab Republic.

Introduction And Importance: Here, we discuss novel management with methotrexate for the rare case of a complete hydatidiform mole with a co-existing fetus (CHMCF). The management of CHMCF is controversial, and methotrexate might represent a solution. CHMCF management with methotrexate needs more study, especially its side effects, safe dosage, and the permissible period of pregnancy. Read More

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Aberrant White Matter Organization Correlated With Neurodevelopment Outcomes in Tetralogy of Fallot: An Atlas-Based Diffusion Tensor Imaging Study.

Pediatr Neurol 2022 May 27;133:15-20. Epub 2022 May 27.

Department of Radiology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China. Electronic address:

Background: White matter injury (WMI) and impaired neurodevelopment are common in children with congenital heart disease. However, the effect of WMI on neurodevelopmental outcomes is still rarely reported. In this study, we aimed to investigate microstructural changes in white matter (WM) and its relationship with neurodevelopmental outcomes and further explore the underlying neurophysiological mechanisms of neurocognitive impairments in the tetralogy of Fallot (ToF). Read More

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Clinical and Echocardiographic Profile of Congenital Heart Diseases in the 0-12-Year Age Group in a Tertiary Care Medical Institute in Eastern India: A Retrospective, Cross-Sectional Study.

Cureus 2022 Jun 20;14(6):e26114. Epub 2022 Jun 20.

Cardiology, Indira Gandhi Institute of Medical Sciences, Patna, IND.

Background This study aimed to determine the clinical and echocardiography profile of congenital heart diseases (CHDs) among admitted children as well as patients presenting to the outpatient department of the Indira Gandhi Institute of Medical Sciences, Patna, which is a tertiary care and apex institute located in Bihar, India. Methodology A retrospective, cross-sectional study was conducted in a tertiary care hospital from January 2019 to January 2021. In total, 200 patients aged 0-12 were enrolled in the study. Read More

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22q11.2 Deletion Syndrome: Impact of Genetics in the Treatment of Conotruncal Heart Defects.

Children (Basel) 2022 May 25;9(6). Epub 2022 May 25.

Pediatric Cardiology Unit, Department of Pediatrics, Obstetrics and Gynecology, "Sapienza" University of Rome, Policlinico Umberto I, 00161 Rome, Italy.

Congenital heart diseases represent one of the hallmarks of 22q11.2 deletion syndrome. In particular, conotruncal heart defects are the most frequent cardiac malformations and are often associated with other specific additional cardiovascular anomalies. Read More

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Integrated multiomic characterization of congenital heart disease.

Nature 2022 Jun 22. Epub 2022 Jun 22.

Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA.

The heart, the first organ to develop, undergoes complex morphogenesis that when defective results in congenital heart disease (CHD). With current therapies, more than 90% of CHD patients survive into adulthood but often suffer premature death from heart failure (HF) and non-cardiac causes . To gain insight into poorly understood disease progression, we performed single nuclear RNA sequencing (snRNA-seq) and analyzed 157,273 nuclei from donors and CHD patients, including hypoplastic left heart syndrome (HLHS) and Tetralogy of Fallot (TOF), two common forms of cyanotic CHD lesions, as well as, dilated (DCM) and hypertrophic (HCM) cardiomyopathies. Read More

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Unrepaired tetralogy of Fallot in the adult: an unexpected diagnosis.

Cardiol Young 2022 Jun 22:1-8. Epub 2022 Jun 22.

Department of Cardiology, Santa Marta Hospital, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.

A 40-year-old female is admitted for paroxysmal episodes of exertional dyspnoea, with associated cyanosis, improving with squatting, and a holosystolic murmur radiating to the interscapular area. Echocardiography showed a subaortic ventricular septal defect with left-to-right shunt and overriding aorta. The characteristic murmur prompted us to seek right ventricular outflow tract obstruction. Read More

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Very low birth weight infants with congenital heart disease: A multicenter cohort study in Japan.

J Cardiol 2022 Jun 17. Epub 2022 Jun 17.

Department of Neonatology, Toho-University Oomori Medical Center, Tokyo, Japan.

Background: The frequency, mortality, and morbidity of very low birth weight (VLBW) infants with congenital heart disease (CHD) in Asian countries are limited. In addition, little is known about the risk factors of death in these infants.

Methods: A retrospective, multicenter cohort study was conducted. Read More

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Tetralogy of Fallot Presenting as Severe Hypernatremic Dehydration: A Review of the Importance of Perinatal Care.

S D Med 2022 May;75(5):230-233

Department of Pediatrics, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

We present a case of a female American Indian neonate born via a provider unattended home delivery. Her mother received limited prenatal care and the infant was not examined by a healthcare provider until day of life 10 when she presented to the emergency department for evaluation of a skin rash. She was found to have severe hypernatremic dehydration. Read More

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Baz1b Dosage Influences Cardiovascular Function, Predisposing to Dilated Cardiomyopathy.

FASEB J 2022 May;36 Suppl 1

Laboratory of Vascular and Matrix Genetics, National Heart, Lung, and Blood Institute, Bethesda, MD.

BAZ1B is one of several genes deleted in Williams-Beuren Syndrome (WBS), a complex, multisystem genetic condition that occurs in ~1 in 8000 live births. Also known as Williams Syndrome Transcription Factor (WSTF), BAZ1B is thought to be essential for neural crest migration. To evaluate the impact of Baz1b loss of function, we evaluated the "knockout first" allele of Baz1b . Read More

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Performance of a Risk Analytic Tool (Index of Tissue Oxygen Delivery "IDO2") in Pediatric Cardiac Intensive Care Unit of a Developing Country.

Front Pediatr 2022 3;10:846074. Epub 2022 Jun 3.

Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.

Objective: To determine the performance of a commercially available risk analytic tool (IDO2) to estimate the risk for SVO2 < 40% in patients admitted in cardiac intensive care unit (CICU).

Methods: Medical and T3 records of all patients (aged 1 day to 12 years, weight >2 kg) who received care in the CICU between October 1st, 2019 and October 1st, 2020, had SvO2 lab(s) drawn during CICU course and whose data was transmitted to T3, were included. The average IDO2 Index was computed in the 30-min period immediately prior to each SvO2 measurement and used as a predictor score for SvO2 < 40%. Read More

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Joint analysis of functionally related genes yields further candidates associated with Tetralogy of Fallot.

J Hum Genet 2022 Jun 20. Epub 2022 Jun 20.

Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

Although several genes involved in the development of Tetralogy of Fallot have been identified, no genetic diagnosis is available for the majority of patients. Low statistical power may have prevented the identification of further causative genes in gene-by-gene survey analyses. Thus, bigger samples and/or novel analytic approaches may be necessary. Read More

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A New Family with a Novel Mutation: Practicing Whole Exome Sequencing for Antenatal Diagnosis of Tetralogy of Fallot.

Mol Syndromol 2022 May 26;13(3):206-211. Epub 2022 Jan 26.

Diagnostic Center for Genetic Diseases, Koc University Hospital, Istanbul, Turkey.

which encodes a member of the ovarian tumor domain-containing deubiquitinating enzyme, has recently been associated with autosomal recessive intellectual disability syndrome with seizures and dysmorphic features. Here, we report one additional case with Tetralogy of Fallot (ToF), who has microcephaly and dysmorphic features along with renal parenchymal disease with simple cortical cysts. The family's first pregnancy was medically terminated due to antenatal diagnosis of ToF. Read More

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Rapidly growing cardiac haemangioma in a patient with Tetralogy of Fallot: case report and brief literature review.

Acta Cardiol 2022 Jun 15:1-5. Epub 2022 Jun 15.

Cardiac Surgery Department, Brugmann University Hospital, Université libre de Bruxelles, Brussels, Belgium.

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Systematic Mapping of Conduction Tissue Regions During Congenital Heart Surgery.

Ann Thorac Surg 2022 Jun 11. Epub 2022 Jun 11.

Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah; Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah.

Purpose: Damage to cardiac conduction system is a major risk of congenital cardiac surgery. Localization of conduction system is commonly based on anatomical landmarks which are variable in congenital heart diseases. We introduce a novel technique for identification of conduction tissue regions based on real-time fiberoptic confocal microscopy (FCM). Read More

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Not Your Usual Case of Culture-Negative Endocarditis: A Case Report of Bartonella Endocarditis.

Cureus 2022 May 12;14(5):e24947. Epub 2022 May 12.

Infectious Disease, Sarasota Memorial Hospital, Florida State University College of Medicine, Sarasota, USA.

Advancements in transcatheter interventions have revolutionized the treatment of adult congenital heart disease. We present a case of a 32-year-old male with a history of tetralogy of Fallot with pulmonary atresia diagnosed with spp. culture-negative infective endocarditis (IE) of his Melody valve, necessitating Melody valve replacement. Read More

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Conduction System Pacing in Pediatrics and Congenital Heart Disease, a Single Center Series of 24 Patients.

Pediatr Cardiol 2022 Jun 9. Epub 2022 Jun 9.

Department of Pediatric Cardiology, University of Minnesota, 5th Floor East Building, 2450 Riverside Avenue, Minneapolis, MN, 55454, USA.

His-bundle pacing has demonstrated feasibility in numerous adult studies to reverse and prevent pacing-induced cardiomyopathy, however, is met with higher capture thresholds with deployment sheaths designed for adults with his-bundles in the typical location. To describe 24 pediatric and adult congenital patients post-physiologic pacing. Patients at the University of Minnesota Masonic Children's Hospital with congenital complete heart block or congenital heart disease and atrioventricular block presented for pacemaker placement between November 2019 and January 2021. Read More

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Surgical Treatment Outcomes of Tetralogy of Fallot: Experience of the Cardiovascular Department of the Mohammed VI University Hospital in Marrakech.

Cureus 2022 May 6;14(5):e24773. Epub 2022 May 6.

Department of Cardiovascular Surgery, Mohammed VI University Hospital, Marrakech, MAR.

Background Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. The surgical approach to TOF continues to evolve, with many centers now favoring early repair for TOF. This study aimed to determine the prevalence of postsurgical complications such as pulmonary insufficiency, residual pulmonary stenosis, and interventricular communication. Read More

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Syncope in a pregnant woman with repaired Tetralogy of Fallot: a case report.

Eur Heart J Case Rep 2022 Jun 24;6(6):ytac209. Epub 2022 May 24.

Nork-Marash Medical Center, Armenak Armenakyan St. 13, 0047 Yerevan, Armenia.

Background: Tetralogy of Fallot (TOF) is one of the most widespread cyanotic congenital heart disease (CHD), which can be successfully repaired in the neonatal period. However, residual problems and the surgical technique itself can create a favourable basis for arrhythmias and conduction abnormalities in these patients. Sometimes, these arrhythmias may worsen during pregnancy and require urgent intervention. Read More

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Deep sequencing unveils altered cardiac miRNome in congenital heart disease.

Mol Genet Genomics 2022 Jun 7. Epub 2022 Jun 7.

Department of Genetics, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, Tamil Nadu, 600113, India.

Congenital heart disease (CHD) surges from fetal cardiac dysmorphogenesis and chiefly contributes to perinatal morbidity and cardiovascular disease mortality. A continual rise in prevalence and prerequisite postoperative disease management creates need for better understanding and new strategies to control the disease. The interaction between genetic and non-genetic factors roots the multifactorial status of this disease, which remains incompletely explored. Read More

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Prevalence of Congenital Heart Disease in Chinese Children With Different Birth Weights and Its Relationship to the Neonatal Birth Weight.

Front Pediatr 2022 19;10:828300. Epub 2022 May 19.

Henan Provincial Clinical Research Center for Pediatric Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, China.

Objective: This study aimed to examine the prevalence and the related risk factors of congenital heart disease (CHD) in children with different birth weights in China and the relationship between the subtypes of CHD and birth weight (BW).

Methods: This study conducted a cross-sectional survey on the data collected in the children's congenital heart disease database (CHDD) established in China. This database contained data from one Grade A, Level III Children's Public Hospital in Zhengzhou, Henan. Read More

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Master microRNA-222 regulates cardiac microRNA maturation and triggers Tetralogy of Fallot.

Signal Transduct Target Ther 2022 May 30;7(1):165. Epub 2022 May 30.

Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research, State Key Laboratory of Genetic Engineering, School of Life Sciences, and Children's Hospital, Fudan University, 200438, Shanghai, China.

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Repair with a pulmonary neovalve in tetralogy of fallot. DOES this avoid ventricular dysfunction?

Interact Cardiovasc Thorac Surg 2022 May 30. Epub 2022 May 30.

Cardiovascular Surgeon, Department of Cardiovascular Surgery, Fundación Cardioinfantil-IC. Rosario University.

Introduction: Given the anatomical variations of tetralogy of Fallot (TOF), different surgical techniques can be used to achieve correction. Transannular patches are the most commonly used technique; they are associated with right ventricular dysfunction, the incidence of which can be reduced through pulmonary valve preservation.

Methods: Between January 2010 and July 2019, we performed 274 surgical corrections of TOF at Fundación Cardioinfantil; 63 patients (23%) underwent repair with a transannular patch in addition to a pulmonary neovalve (Group I), 66 patients (24. Read More

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Patch enlargement may not be a good strategy for treating tetralogy of Fallot with unbalanced pulmonary artery branches.

Eur J Cardiothorac Surg 2022 Jun;62(1)

Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine. 1678 Dongfang Road, Shanghai 200127, People's Republic of China.

Objectives: Our goal was to determine the optimal strategy for managing tetralogy of Fallot (TOF) with unbalanced pulmonary artery (PA) branches by investigating the different effects of PA plasty on the development of hypoplastic PA (HPA).

Methods: A single-centre, retrospective analysis was carried out to compare the outcome of different PA plasty methods on the development of HPA in patients with TOF with unbalanced PA branches. Size and balance of the PA branches were used to evaluate the outcome of PA plasty. Read More

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An Up-to-Date Narrative Review on Congenital Heart Disease Percutaneous Treatment in Children Using Contemporary Devices.

Diagnostics (Basel) 2022 May 10;12(5). Epub 2022 May 10.

Department of Pediatrics, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.

Background: Congenital heart pathology has a significant burden regarding morbidity and mortality in the pediatric population. Several transcatheter interventions and devices have been designed as an alternative to surgical repair. Percutaneous interventions have been proven to yield good results in most cases but with less stress and trauma than that attributed to surgical treatment, especially in frail pediatric patients. Read More

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The fate of the fresh autologous pericardium after right ventricular outflow tract reconstruction.

J Cardiovasc Thorac Res 2022 7;14(1):47-52. Epub 2022 Mar 7.

Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

The autologous pericardium, treated or fresh, is used in reconstructive cardiovascular surgery. We aimed to describe the features of fresh pericardium utilized in right ventricular outflow tract (RVOT) reconstruction, years after the initial surgery. This cross-sectional study was performed on 72 patients (65. Read More

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Right Ventricular Outflow Tract Surgical Resection in Young, Large Animal Model for the Study of Alternative Cardiovascular Patches.

Methods Mol Biol 2022 ;2485:299-309

Cellular, Molecular and Developmental Biology Program, Graduate School of Biomedical Sciences, Tufts University, Boston, MA, USA.

Tetralogy of Fallot (ToF) is a severe congenital heart defect (CHD) that requires surgical reconstruction soon after birth. Reconstructive surgery involves the implantation of synthetic cardiovascular patches to widen the right ventricular outflow tract (RVOT) and repair defects in the septal wall. However, synthetic patches can cause complications for these patients later in life as they do not integrate or adapt in the tissue of a growing patient; a limitation that could be solved with the development of a patch fabricated from a degradable biomaterial. Read More

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