11,544 results match your criteria Tetralogy of Fallot


The role of diagnostic cardiac catheterization for children with congenital heart diseases: local experience.

Authors:
Reham Wagdy

Arch Med Sci Atheroscler Dis 2018 28;3:e72-e79. Epub 2018 Jun 28.

Department of Pediatrics, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Introduction: Despite the development of non-invasive tools of investigations for congenital heart diseases (CHDs), still the role of diagnostic cardiac catheterization (DCC) cannot be undermined. The study aimed to analyze the clinical profile of indicated CHDs cases at our center for DCC to evaluate the contribution of DCC in patients' management plans.

Material And Methods: The study checked files of cases performed DCC between 2011 and 2012 at the pediatric catheterization unit of Alexandria University Children's Hospital by the same operator. Read More

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http://dx.doi.org/10.5114/amsad.2018.76824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374569PMC

Outcomes After Initial Unifocalization to a Shunt in Complex Tetralogy of Fallot with MAPCAs.

Ann Thorac Surg 2019 Feb 14. Epub 2019 Feb 14.

Background: Our approach to tetralogy of Fallot (TOF) with pulmonary atresia and major aortopulmonary collateral arteries (MAPCAs) emphasizes early single-stage unifocalization and intracardiac repair. However, a subset of patients with small native pulmonary arteries (PAs) and MAPCAs undergo unifocalization to a shunt rather than simultaneous intracardiac repair.

Methods: Patients with TOF/MAPCAs who underwent unifocalization to a systemic-to-PA shunt by a single surgeon were reviewed. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.030DOI Listing
February 2019

GATA4 molecular screening and assessment of environmental risk factors in a Moroccan cohort with tetralogy of Fallot.

Afr Health Sci 2018 Dec;18(4):922-930

Medico-Surgical Unit of Cardio-Pediatrics, Department of Pediatrics, HASSAN II University Hospital, Fez, Morocco.

Background: Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart defect (CHD) with an incidence of 1/3600 live births. This disorder was associated with mutations in the transcription factors involved in cardiogenesis, like Nk2 homeobox5 (NKX2-5), GATA binding protein4 (GATA4) and T-BOX1 (TBX1). GATA4 contributes particularly to heart looping and differentiation of the second heart field. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354854PMC
December 2018
1 Read

Can Echocardiographic Right Ventricular Function Parameters Predict Vasoactive Support Requirement After Tetralogy of Fallot Repair?

J Cardiothorac Vasc Anesth 2019 Jan 12. Epub 2019 Jan 12.

Department of Biostatistics, AIIMS, New Delhi, India.

Objective: To evaluate the role of echocardiographic right ventricular function parameters in predicting postoperative vasoactive inotrope requirement after tetralogy of Fallot repair.

Design: Prospective observational study.

Setting: A tertiary care hospital. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10530770193006
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http://dx.doi.org/10.1053/j.jvca.2019.01.036DOI Listing
January 2019
2 Reads

Another Notch in the Genetic Puzzle of Tetralogy of Fallot.

Circ Res 2019 Feb;124(4):462-464

From the Center for Cardiovascular Research and Heart Center, Nationwide Children's Hospital, Columbus, OH (A.M.-N., J.Y., V.G.).

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314520DOI Listing
February 2019

Tetralogy of Fallot and abnormal coronary artery: use of a prosthetic conduit is outdated.

Eur J Cardiothorac Surg 2019 Feb 11. Epub 2019 Feb 11.

Department of Pediatric Cardiac Surgery, Necker Sick Children Hospital-M3C, University Paris Descartes, Paris, France.

Objectives: Repair of tetralogy of Fallot (ToF) can be challenging in the presence of an abnormal coronary artery (CA) in 5-12% of cases. The aim of this study was to report our experience with ToF repair without the systematic use of a right ventricle-to-pulmonary artery (RV-PA) conduit.

Methods: We conducted a monocentric retrospective study from 2000 to 2016, including 943 patients with ToF who underwent biventricular repair, of whom 8% (n = 76) presented with an abnormal CA. Read More

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http://dx.doi.org/10.1093/ejcts/ezz030DOI Listing
February 2019
1 Read

Short-term clinical and echocardiographic outcomes after use of polytetrafluoroethylene bicuspid pulmonary valve during the repair of tetralogy of Fallot.

Ann Pediatr Cardiol 2019 Jan-Apr;12(1):25-31

Department of Pediatric Cardiac Sciences, Sir Ganga Ram Hospital, Delhi, India.

Background: Application of transannular patch (TAP) during the repair of tetralogy of Fallot (TOF) leads to the development of pulmonary regurgitation (PR). This PR is known to cause right ventricular (RV) volume overload and dysfunction which in turn leads to increase in both morbidity and mortality both in immediate and long-term periods. Here, we sought to analyze the effects of polytetrafluoroethylene (PTFE) pulmonary bicuspid valve on the early outcome of patients with TOF repair where TAP is needed. Read More

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http://dx.doi.org/10.4103/apc.APC_51_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343384PMC
February 2019
1 Read

Early right ventricular function following trans-right atrial versus trans-right atrial, trans-right ventricular repair of Tetralogy of Fallot: Results of a prospective randomized study.

Ann Pediatr Cardiol 2019 Jan-Apr;12(1):3-9

Cardiothoracic Center, All India Institute of Medical Sciences, New Delhi, India.

Objective: We compared the pre- and post-operative right ventricular (RV) function by tricuspid annular plane systolic excursion (TAPSE) between trans-right atrial (t-RA) versus t-RA/RV (RA/RV) approach for the repair of Tetralogy of Fallot (TOF).

Patients And Methods: Fifty consecutive patients, 1-15 years of age, undergoing intracardiac repair of TOF between September 2015 and June 2016 were randomized into two groups based on the approach for repair as follows: t-RA or t-RA/RV approach. TAPSE was used for the assessment of pre- and post-operative RV function. Read More

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http://dx.doi.org/10.4103/apc.APC_40_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343382PMC
February 2019
1 Read

Concomitant Valve-sparing Aortic Root Replacement with Repair of Tetralogy of Fallot.

Ann Thorac Surg 2019 Feb 8. Epub 2019 Feb 8.

Division of Cardiovascular Surgery. Electronic address:

Valve-sparing aortic root replacement is one of the effective repairs for aortic regurgitation resulting from progressive dilatation of the aortic root late after surgical correction of conotruncal anomaly. However, feasibility and effectiveness of this procedure are unknown for unrepaired physiology. A 32 year-old man presented with unrepaired Tetralogy of Fallot (TOF) and moderate aortic regurgitation with severe left ventricular dysfunction. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.010DOI Listing
February 2019
1 Read

Aortic dilatation in complex congenital heart disease.

Authors:
Koichiro Niwa

Cardiovasc Diagn Ther 2018 Dec;8(6):725-738

Department of Cardiology, Cardiovascular Center, St Luke's International Hospital, Tokyo, Japan.

A bicuspid aortic valve and/or coarctation of the aorta (COA) are often associated with dilatation of the ascending aorta and para-coarctation. Congenital heart diseases (CHD), such as truncus arteriosus, transposition of the great arteries (TGA), tetralogy of Fallot (TOF), hypoplastic left heart syndrome (HLHS), single ventricle with pulmonary stenosis/atresia and the Fontan procedure, are also associated with aortic root dilatation, aneurysm and rarely, dissection, which can be fatal and require aortic valve and root surgery. A significant subset of adults with complex CHD exhibit progressive dilatation of the aortic root even after repair due to aortic medial degeneration. Read More

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http://cdt.amegroups.com/article/view/23120/22178
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http://dx.doi.org/10.21037/cdt.2018.12.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331370PMC
December 2018
3 Reads

The closing process of the ductus arteriosus connecting the left common carotid artery and main pulmonary artery.

Cardiol Young 2019 Feb 11:1-3. Epub 2019 Feb 11.

Department of Pediatric Cardiology,Osaka Women's and Children's Hospital,Osaka,Japan.

An isolated left common carotid artery is very rare, and only 13 cases have been reported thus far. All those cases were accompanied by a right aortic arch and aberrant left subclavian artery, and the connecting vessel between the pulmonary artery and left common carotid artery was thought to be ductal tissue. However, there have been no reports that have followed the natural closure of this vessel. Read More

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http://dx.doi.org/10.1017/S1047951118002275DOI Listing
February 2019
1 Read

Total Correction of Tetralogy of Fallot in the First 60 Days of Life in Symptomatic Infants: Is It The Gold Standard?

Thorac Cardiovasc Surg 2019 Feb 9. Epub 2019 Feb 9.

Benha University, Benha, Egypt.

Background:  The timing of surgical repair of tetralogy of Fallot (TOF) is a key to alleviate complications and for long-term survival. Total correction was usually performed at the age of 6 months or older under the notion of decreasing the surgical risk. However, avoiding palliation with an aortopulmonary shunt and early correction of systemic hypoxia appear to be of more benefit than the inborn surgical risk in low body weight patients. Read More

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http://dx.doi.org/10.1055/s-0039-1678698DOI Listing
February 2019
1 Read

Endocarditis following IUD insertion in a patient with tetralogy of Fallot.

BMJ Case Rep 2019 Feb 7;12(2). Epub 2019 Feb 7.

Department of Medicine, University of Washington, Seattle, Washington, USA.

The role of antibiotic prophylaxis for prevention of infective endocarditis is unknown. Endocarditis prophylaxis is recommended for certain high-risk individuals prior to dental procedures. To our knowledge, this is the first case reported in the literature of a patient with complex congenital heart disease developing endocarditis in the period immediately following otherwise uncomplicated intrauterine device insertion. Read More

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http://dx.doi.org/10.1136/bcr-2018-227962DOI Listing
February 2019
1 Read

Intraesophageal aortopulmonary collateral artery occlusion in an infant with Tetralogy of Fallot and flow-dependent major aortopulmonary collateral arteries.

Cardiovasc Pathol 2019 Jan 9;39:74-76. Epub 2019 Jan 9.

Patients with flow-dependent aortopulmonary collateral arteries often exhibit tenuous clinical statuses. Here we present an infant with Tetralogy of Fallot with pulmonary atresia (TOF-PA) and major aortopulmonary collateral arteries (MAPCAs) who experienced clinically significant oxygen desaturations during feedings. These frequent episodes were attributed to gastroesophageal reflux. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.12.009DOI Listing
January 2019
1 Read

Accuracy of risk prediction scores in pregnant women with congenital heart disease.

Congenit Heart Dis 2019 Feb 6. Epub 2019 Feb 6.

Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine Philadelphia, Pennsylvania.

Objective: To assess performance of risk stratification schemes in predicting adverse cardiac outcomes in pregnant women with congenital heart disease (CHD) and to compare these schemes to clinical factors alone.

Design: Single-center retrospective study.

Setting: Tertiary care academic hospital. Read More

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http://dx.doi.org/10.1111/chd.12750DOI Listing
February 2019
2 Reads

Evaluation using a four-dimensional imaging tool before and after pulmonary valve replacement in a patient with tetralogy of Fallot: a case report.

J Med Case Rep 2019 Feb 5;13(1):30. Epub 2019 Feb 5.

Department of Pediatric Cardiovascular Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Background: Pulmonary regurgitation is a common complication after tetralogy of Fallot repair, resulting in right ventricular dysfunction, arrhythmia, and sudden death. However, the indications and optimal timing for pulmonary valve replacement are not fully known. We describe a case in which a four-dimensional imaging tool was useful in the decision to re-operate, thus resulting in decreased energy loss and improved right ventricular function after the re-operation for tetralogy of Fallot. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-018-1964-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362591PMC
February 2019
6 Reads

Impact of age and cardiac disease on regional left and right ventricular myocardial motion in healthy controls and patients with repaired tetralogy of fallot.

Int J Cardiovasc Imaging 2019 Feb 4. Epub 2019 Feb 4.

Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Avenue, Suite 1600, Chicago, IL, 60611, USA.

The assessment of both left (LV) and right ventricular (RV) motion is important to understand the impact of heart disease on cardiac function. The MRI technique of tissue phase mapping (TPM) allows for the quantification of regional biventricular three-directional myocardial velocities. The goal of this study was to establish normal LV and RV velocity parameters across a wide range of pediatric to adult ages and to investigate the feasibility of TPM for detecting impaired regional biventricular function in patients with repaired tetralogy of Fallot (TOF). Read More

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http://dx.doi.org/10.1007/s10554-019-01544-6DOI Listing
February 2019
1 Read
2.322 Impact Factor

Elevated diastolic wall shear stress in regurgitant semilunar valvular lesions.

J Magn Reson Imaging 2019 Feb 4. Epub 2019 Feb 4.

Pediatric Cardiology and Congenital Heart Disease, German Heart Center at Technical University of Munich, Munich, Germany.

Background: Alterations in wall shear stress (WSS) assessed using 4D flow MRI have been shown to play a role in various vascular pathologies, such as bicuspid aortic valve aortopathy. Most studies have focused on systolic WSS, whereas altered diastolic hemodynamics in regurgitant semilunar valvular lesions have not so far been well characterized.

Purpose: To investigate diastolic WSS in aortic and pulmonary regurgitation. Read More

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http://dx.doi.org/10.1002/jmri.26680DOI Listing
February 2019
1 Read

Isolation of left subclavian artery in Tetralogy of Fallot with right aortic arch: A rare association diagnosed on dual source CT.

J Cardiovasc Comput Tomogr 2019 Jan 24. Epub 2019 Jan 24.

Department of Cardiovascular Radiology and Endovascular, Interventions, All India Institute of Medical Sciences, New Delhi, 110029, India.

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http://dx.doi.org/10.1016/j.jcct.2019.01.017DOI Listing
January 2019
6 Reads

Prenatal detection of right aortic arch.

Arch Gynecol Obstet 2019 Jan 31. Epub 2019 Jan 31.

Department of Gynecology and Obstetrics, Division of Feto-Maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Purpose: To examine an unselective population of fetuses with right aortic arch (RAA) and suggest perinatal management. Second, to evaluate the importance and possible implication of fetal MRI in those cases.

Methods: Retrospective study of 36 patients with RAA diagnosed prenatally between 2006 and 2017 in a tertiary referral center. Read More

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http://dx.doi.org/10.1007/s00404-019-05056-5DOI Listing
January 2019
1 Read

Early outcomes of transcatheter tricuspid valve-in-valve implantation: a case series.

Interact Cardiovasc Thorac Surg 2019 Jan 25. Epub 2019 Jan 25.

Cardiopneumology Department, InCor-Heart Institute of the University of São Paulo Clinic's Hospital, São Paulo, Brazil.

Objectives: In this study, we sought to evaluate early outcomes of transcatheter valve-in-valve implantation in patients with a degenerated bioprosthesis in the tricuspid position.

Methods: We used a prospective study, which included patients with a degenerated bioprosthesis in the tricuspid position who were considered high-risk by our heart team and who underwent a valve-in-valve implantation. The procedures were performed via transjugular venous access and were done with the patient under general anaesthesia with transoesophageal echocardiographic and fluoroscopic guidance. Read More

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https://academic.oup.com/icvts/advance-article/doi/10.1093/i
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http://dx.doi.org/10.1093/icvts/ivy362DOI Listing
January 2019
5 Reads

The roles of vascular endothelial growth factor gene polymorphisms in congenital heart diseases: a meta-analysis.

Growth Factors 2019 Jan 28:1-7. Epub 2019 Jan 28.

a Department of Pediatrics , Changyi People's Hospital , Changyi , China.

We performed this study to better elucidate the correlations between vascular endothelial growth factor (VEGF) gene polymorphisms and congenital heart diseases (CHD). Eligible articles were searched in PubMed, Medline, Embase and CNKI. Eighteen studies were finally included in our meta-analysis. Read More

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http://dx.doi.org/10.1080/08977194.2018.1513505DOI Listing
January 2019
1 Read

Sacubitril/Valsartan in Adult Congenital Heart Disease Patients With Chronic Heart Failure - A Single Centre Case Series and Call for an International Registry.

Heart Lung Circ 2018 Dec 17. Epub 2018 Dec 17.

Department of Cardiology, Mater Hospital Services, Brisbane, Qld, Australia; School of Medicine, The University of Queensland, Brisbane, Qld, Australia; Department of Cardiology, The Prince Charles Hospital, Metro North Hospital and Health Service, Brisbane, Qld, Australia.

Background: An improvement in life expectancy in patients suffering from adult congenital heart disease (ACHD) has corresponded with a rise in heart failure incidence within this group. An area that has not been addressed in ACHD heart failure guidelines has been the use of combined inhibition of angiotensin receptor-neprolysin pathways. This case series sought to demonstrate tolerability and 6-month outcome measures of sacubitril/valsartan use in ACHD patients with a severely impaired systemic ventricle. Read More

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http://dx.doi.org/10.1016/j.hlc.2018.12.003DOI Listing
December 2018
1 Read

Ramipril for left ventricular diastolic function in patients with pulmonary regurgitation after repair of tetralogy of Fallot.

Authors:
Lin Xie Ke Lin

Int J Cardiol 2019 Mar;278:95

Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2018.11.006DOI Listing
March 2019
2 Reads

Ramipril for left ventricular diastolic function in patients with pulmonary regurgitation after repair of tetralogy of Fallot.

Int J Cardiol 2019 Mar;278:93

Royal Brompton & Harefield NHS Foundation Trust, UK; National Heart and Lung Institute, Imperial College London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2018.12.038DOI Listing
March 2019
1 Read
4.036 Impact Factor

Time to reconsider when to re-valve for free pulmonary regurgitation in tetralogy of Fallot?

EuroIntervention 2019 Jan;14(13):1344-1346

Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.4244/EIJV14I13A242DOI Listing
January 2019
2 Reads

Absent Pulmonary Valve Syndrome in a Fetus: A Case Report and Literature Review.

Fetal Pediatr Pathol 2019 Jan 20:1-6. Epub 2019 Jan 20.

c Department of Medical Ultrasound , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.

Introduction: The main characteristics of absent pulmonary valve syndrome (APVS) include the absence or hypoplasia of the pulmonary valve, stenosis of the pulmonary valve annulus, and aneurysmal dilatation of the pulmonary trunk and its branches. In the more common type 1, the tetralogy of Fallot-like type, there is a ventricular septal defect, overriding aorta, pulmonary arterial dilatation, and absence of ductus arteriosus, The second type has an intact ventricular septum, less pulmonary artery dilatation, and a patent ductus arteriosus, with or without tricuspid atresia.

Case Report: This APVS had an intact ventricular septum with an absent ductus arteriosus. Read More

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https://www.tandfonline.com/doi/full/10.1080/15513815.2018.1
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http://dx.doi.org/10.1080/15513815.2018.1529066DOI Listing
January 2019
12 Reads

Tetralogy of Fallot: morphological variations and implications for surgical repair.

Eur J Cardiothorac Surg 2019 Jan 16. Epub 2019 Jan 16.

Department of Paediatric Cardiac Surgery, Birmingham Children's Hospital, Birmingham, UK.

Objectives: Tetralogy of Fallot is characterized by anterocephalad deviation of the outlet septum, along with abnormal septoparietal trabeculations, which lead to subpulmonary infundibular stenosis. Archives of retained hearts are an important resource for improving our understanding of congenital heart defects and their morphological variability. This study aims to define variations in aortic override, coronary arterial patterns and ventricular septal defects in tetralogy of Fallot as observed in a morphological archive, highlighting implications for surgical management. Read More

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http://dx.doi.org/10.1093/ejcts/ezy474DOI Listing
January 2019
4 Reads

'Absent' pulmonary valve with intact ventricular septum mimicking tricuspid valve atresia: Prenatal diagnosis and postnatal course.

J Obstet Gynaecol Res 2019 Jan 17. Epub 2019 Jan 17.

Pediatric Cardiology, Tuscany Region-National Centre for Research Foundation, Ospedale del Cuore, Massa, Italy.

Absent pulmonary valve syndrome is a rare congenital heart disease characterized by absent or rudimentary pulmonary valve leaflets and hypoplastic pulmonary annulus. The most common variant, associated with tetralogy of Fallot, implies dilatation of pulmonary branches and usually absent ductus arteriosus. Rarely, absent pulmonary valve occurs with intact ventricular septum: pulmonary branches are normally sized or mildly dilated and ductus arteriosus is usually patent. Read More

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http://dx.doi.org/10.1111/jog.13878DOI Listing
January 2019
9 Reads

Circulating Transforming Growth Factor-β and Aortic Dilation in Patients with Repaired Congenital Heart Disease.

Sci Rep 2019 Jan 17;9(1):162. Epub 2019 Jan 17.

Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Pok Fu Lam, China.

This study determined the circulating levels of TGF-β1 and its association with aortic dilation and elastic properties in congenital heart patients. Forty-six patients after tetralogy of Fallot (TOF) repair, 21 patients post arterial switch and 15 patients post atrial switch for transposition of the great arteries (TGA), 27 patients post Fontan procedure, and 36 controls were studied. Aortic dimensions and elastic properties and ventricular function were assessed by echocardiography. Read More

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http://dx.doi.org/10.1038/s41598-018-36458-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336785PMC
January 2019
3 Reads

Relative Impact of Right Ventricular Electromechanical Dyssynchrony Versus Pulmonary Regurgitation on Right Ventricular Dysfunction and Exercise Intolerance in Patients After Repair of Tetralogy of Fallot.

J Am Heart Assoc 2019 Jan;8(2):e010903

1 Division of Cardiology Labatt Family Heart Centre and Department of Paediatrics Hospital for Sick Children and University of Toronto Toronto Ontario Canada.

Background The relative impact of right ventricular ( RV ) electromechanical dyssynchrony versus pulmonary regurgitation ( PR ) on exercise capacity and RV function after tetralogy of Fallot repair is unknown. We aimed to delineate the relative effects of these factors on RV function and exercise capacity. Methods and Results We retrospectively analyzed 81 children with tetralogy of Fallot repair using multivariable regression. Read More

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http://dx.doi.org/10.1161/JAHA.118.010903DOI Listing
January 2019
3 Reads

The Society of Thoracic Surgeons Congenital Heart Surgery Database: 2019 Update on Outcomes and Quality.

Ann Thorac Surg 2019 Mar 11;107(3):691-704. Epub 2019 Jan 11.

Division of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland; Division of Cardiovascular Surgery, Department of Surgery, Johns Hopkins All Children's Heart Institute, Johns Hopkins All Children's Hospital and Florida Hospital for Children, Saint Petersburg, Tampa, and Orlando, Florida.

The Society of Thoracic Surgeons Congenital Heart Surgery Database is a comprehensive clinical outcomes registry that captures almost all pediatric cardiac surgical operations in the United States. It is the platform for all activities of The Society of Thoracic Surgeons related to the analysis of outcomes and the improvement of quality in this subspecialty. This report summarizes current aggregate national outcomes in congenital and pediatric cardiac surgery and reviews related activities in the areas of quality measurement, performance improvement, and transparency. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034975193006
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http://dx.doi.org/10.1016/j.athoracsur.2018.12.016DOI Listing
March 2019
14 Reads

Proteomics analysis indicated the protein expression pattern related to the development of fetal conotruncal defects.

J Cell Physiol 2019 Jan 12. Epub 2019 Jan 12.

Department of Ultrasonography, Women's Hospital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital), Nanjing, China.

Abnormal development of embryonic conus arteriosus could lead to conotruncal defects in fetal heart, and increase the incidence of fetal congenital heart disease. Tetralogy of Fallot (TOF) is one of the most common forms of congenital heart disease. It may be helpful for us to solve this clinical problem through exploring the molecular mechanisms of development in embryonic congenital heart disease. Read More

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http://dx.doi.org/10.1002/jcp.28033DOI Listing
January 2019
2 Reads

The effect of tadalafil on functional capacity and echocardiographic parameters in patients with repaired Tetralogy of Fallot.

ARYA Atheroscler 2018 Jul;14(4):177-182

Pediatric Cardiology Fellow, Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Tetralogy of Fallot (TOF) is one of the most common cyanotic congenital heart diseases (CHD) in children. Various surgical procedures including palliative shunts and TOF total correction (TFTC) were done with some complications, of which, the most common is pulmonary valve regurgitation (PR). Tadalafil is a phosphodiesterase 5 inhibitor which reduces pulmonary vascular resistance, and improves right ventricular function and vascular endothelium, and may have some beneficial effects after TFTC. Read More

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http://dx.doi.org/10.22122/arya.v14i4.1561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312565PMC
July 2018
4 Reads

Semiautomatic Three-Dimensional Threshold-Based Cardiac Computed Tomography Ventricular Volumetry in Repaired Tetralogy of Fallot: Comparison with Cardiac Magnetic Resonance Imaging.

Authors:
Hyun Woo Goo

Korean J Radiol 2019 Jan 27;20(1):102-113. Epub 2018 Dec 27.

Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Objective: To assess the accuracy and potential bias of computed tomography (CT) ventricular volumetry using semiautomatic three-dimensional (3D) threshold-based segmentation in repaired tetralogy of Fallot, and to compare them to those of two-dimensional (2D) magnetic resonance imaging (MRI).

Materials And Methods: This retrospective study evaluated 32 patients with repaired tetralogy of Fallot who had undergone both cardiac CT and MRI within 3 years. For ventricular volumetry, semiautomatic 3D threshold-based segmentation was used in CT, while a manual simplified contouring 2D method was used in MRI. Read More

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http://dx.doi.org/10.3348/kjr.2018.0237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315063PMC
January 2019
1 Read

Maternal Overweight and Obesity and Risk of Congenital Heart Defects.

J Am Coll Cardiol 2019 Jan;73(1):44-53

Department of Medicine, Solna, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden.

Background: Congenital heart defects are more frequent in offspring of mothers with overweight or obesity. However, associations between maternal overweight and obesity, and risks of complex and specific heart defects are not clear.

Objectives: This study sought to analyze associations between maternal overweight and obesity severity and rates of complex and specific heart defects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07351097183908
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http://dx.doi.org/10.1016/j.jacc.2018.10.050DOI Listing
January 2019
8 Reads

Cardiovascular imaging approach in pre and postoperative tetralogy of Fallot.

BMC Cardiovasc Disord 2019 Jan 7;19(1). Epub 2019 Jan 7.

Mid-German Heart Center, Department of Internal Medicine III (KIM-III), Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle, Ernst-Grube-Strasse 40, D-06120, Halle (Saale), Germany.

Advances in the medical and surgical management of Tetralogy of Fallot have led to marked increase of the number and age of survivors. Imaging in patients with Tetralogy of Fallot plays a crucial role in the diagnosis and follow up, and essentially guides management and intervention in this entity. This study systematically reviews the imaging modalities used in patients with Tetralogy of Fallot in the evaluation of preoperative and postoperative anatomic and hemodynamic lesions, as well as disease progression in this diagnosis. Read More

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http://dx.doi.org/10.1186/s12872-018-0996-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323806PMC
January 2019
2 Reads

Serial Follow-Up of Two Surgical Strategies for the Repair of Tetralogy of Fallot.

Semin Thorac Cardiovasc Surg 2019 Jan 5. Epub 2019 Jan 5.

University of Rochester Medical Center, Division of Cardiac Surgery, Department of Surgery, Rochester, New York. Electronic address:

Adverse events following tetralogy of Fallot repair include arrhythmia, reoperation, and death. While limiting the right ventriculotomy mitigates these events over the short and intermediate term, the impact over the long term is unknown. Children requiring tetralogy of Fallot repair were divided into 2 groups: extended right ventriculotomy vs limited right ventriculotomy with transatrial ventricular septal defect closure. Read More

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http://dx.doi.org/10.1053/j.semtcvs.2019.01.006DOI Listing
January 2019
3 Reads

Repair of Untreated Older Patients with Tetralogy of Fallot with Major Aortopulmonary Collaterals (Commentary).

Authors:
Yves d'Udekem

Ann Thorac Surg 2019 Jan 3. Epub 2019 Jan 3.

Department of Cardiac Surgery, The Royal Children's Hospital Melbourne, Murdoch Childrens Research Institute, Melbourne; Department of Paediatrics, Faculty of Medicine, The University of Melbourne, 50 Flemington road, Melbourne, Vi 3052, Australia.

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http://dx.doi.org/10.1016/j.athoracsur.2018.12.003DOI Listing
January 2019
1 Read

Rare mutations of from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling.

Clin Sci (Lond) 2019 Jan 22;133(2):225-238. Epub 2019 Jan 22.

Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, State Key Laboratory of Genetic Engineering at School of Life Sciences, Fudan University, Shanghai 200011, China

Tetralogy of Fallot (TOF) is the most common cyanotic form of congenital heart defects (CHDs). The right ventricular hypertrophy is associated with the survival rate of patients with repaired TOF. However, very little is known concerning its genetic etiology. Read More

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http://clinsci.org/lookup/doi/10.1042/CS20180842
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http://dx.doi.org/10.1042/CS20180842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365624PMC
January 2019
8 Reads

Single-Stage Complete Repair versus Multistage Repair of Tetralogy of Fallot with Borderline Pulmonary Arteries.

Heart Surg Forum 2018 Nov 13;21(6):E466-E471. Epub 2018 Nov 13.

Department of Cardiothoracic Surgery, Al Ahrar Hospital, Zagazig, Egypt.

Background: Tetralogy of Fallot is the most common cyanotic congenital heart defect. Borderline pulmonary anatomy has been associated with a higher risk of mortality and morbidity. Strategies to manage this condition-namely, single- or multistage repair-have long been debated. Read More

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http://dx.doi.org/10.1532/hsf.2075DOI Listing
November 2018
2 Reads

Prenatal Diagnosis and Management of Ectopia Cordis: Varied Presentation Spectrum.

Fetal Pediatr Pathol 2019 Jan 2:1-11. Epub 2019 Jan 2.

a Department of Obstetrics and Gynecology, Istanbul Faculty of Medicine , Istanbul University , Istanbul , Turkey.

Background: Ectopia cordis (EC) is a congenital anomaly associated with heart defects and extracardiac malformations.

Objectives: We determined the various presentations of EC diagnosed in our center between 2010 and 2017.

Results: Seven fetuses from six pregnancies with EC were detected, five during the first trimester. Read More

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https://www.tandfonline.com/doi/full/10.1080/15513815.2018.1
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http://dx.doi.org/10.1080/15513815.2018.1556367DOI Listing
January 2019
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Utility of Doppler Echocardiography to Estimate the Severity of Pulmonary Valve Regurgitation Fraction in Patients with Repaired Tetralogy of Fallot.

Pediatr Cardiol 2019 Jan 2. Epub 2019 Jan 2.

Division of Cardiology, Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI, 48201-2119, USA.

Background: In patients with repaired Tetralogy of Fallot (rTOF), pulmonary regurgitation (PR) leads to significant morbidity. Cardiac magnetic resonance imaging (CMR) is the gold standard to assess severity of PR in rTOF patients. We compared Doppler echocardiography derived indices of PR with CMR to find the best predictive parameter for hemodynamically significant (hs) PR. Read More

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http://dx.doi.org/10.1007/s00246-018-2045-yDOI Listing
January 2019
1 Read
1.550 Impact Factor

Exercise stress CMR reveals reduced aortic distensibility and impaired right-ventricular adaptation to exercise in patients with repaired tetralogy of Fallot.

PLoS One 2018 31;13(12):e0208749. Epub 2018 Dec 31.

Aix-Marseille Univ, CNRS, CRMBM, Marseille, France.

Background: The aim of our study was to evaluate the feasibility of exercise cardiac magnetic resonance (CMR) in patients with repaired tetralogy of Fallot (RTOF) and to assess right and left ventricular adaptation and aortic wall response to exercise in comparison with volunteers.

Methods: 11 RTOF and 11 volunteers underwent prospective CMR at rest and during exercise. A supine bicycle ergometer was employed to reach twice the resting heart rate during continuous exercise, blood pressure and heart rate were recorded. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208749PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312273PMC
December 2018
1 Read

Surgical repair of Tetralogy of Fallot following primary palliation: Right ventricular outflow track stenting versus modified Blalock-Taussig shunt.

Indian Heart J 2018 Dec 24;70 Suppl 3:S394-S398. Epub 2018 Jun 24.

Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Tetralogy of Fallot (TOF) is a cyanotic disease requiring early intervention. We assessed the effect of right ventricular outflow tract (RVOT) stenting versus modified Blalock-Taussig shunt (mBTS) on outcomes of surgical repair of TOF.

Methods: Fifteen palliated TOF infants underwent complete repair surgery. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309724PMC
December 2018
1 Read

Anesthesia for high-risk procedures in the catheterization laboratory.

Paediatr Anaesth 2018 Dec 28. Epub 2018 Dec 28.

Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Recent advances in catheterization and imaging technology allow for more complex procedures to be performed in the catheterization laboratory. A number of lesions are now amenable to a percutaneous procedure, eliminating or at least postponing the need for a surgical intervention. Due to the increase in the complexity of the procedures performed, the involvement of anesthesiologists and their close collaboration with the interventional cardiologists have increased. Read More

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http://dx.doi.org/10.1111/pan.13571DOI Listing
December 2018
6 Reads

Anaesthetic management of uncorrected Tetralogy of Fallot and mitochondrial disorder: a role for Dexmedetomidine.

Paediatr Anaesth 2018 Dec 28. Epub 2018 Dec 28.

Queensland Children's Hospital, Department of Cardiology, Brisbane, Australia.

The case presented is a patient with uncorrected cyanotic congenital heart disease (CHD) and a mitochondrial disorder, and highlights the need for understanding of the physiological sequelae and impact of anaesthesia for these disorders. A 9-year-old boy with uncorrected Tetralogy of Fallot (TOF) and mitochondrial disorder presented for palliative right ventricular outflow tract (RVOT) stent insertion. Given the severity of his developmental delay and guarded prognosis, definitive surgical management was not undertaken earlier in life. Read More

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http://dx.doi.org/10.1111/pan.13570DOI Listing
December 2018
3 Reads

Tetralogy of Fallot: Everything You Wanted to Know but Were Afraid to Ask.

Paediatr Anaesth 2018 Dec 27. Epub 2018 Dec 27.

Department of Surgery, Stanford University, Palo Alto, USA.

Tetralogy of Fallot (TOF) is the most common form of congenital cyanotic heart disease, occurring in approximately 4 to 5 per 10,0000 live births, and represents 7-10% of all congenital heart defects (1,2). Although TOF is often thought of in terms of the tetrad of anomalies-pulmonary stenosis, ventricular septal defect (VSD), aorta overriding the ventricular septum, and right ventricular hypertrophy-it has been proposed that all of these features are the result of anterior malalignment of the infundibular septum with the muscular septum (3,4). There are several variants of TOF as well, which manifest other abnormal features and are discussed in the following review. Read More

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http://dx.doi.org/10.1111/pan.13569DOI Listing
December 2018
2 Reads

Surgical ablation of ventricular tachycardia in patients with repaired tetralogy of Fallot.

Eur J Cardiothorac Surg 2018 Dec 22. Epub 2018 Dec 22.

Department of Congenital Cardiac Surgery, IRCCS Policlinico San Donato, San Donato Milanese, Italy.

Objectives: Life expectancy of patients with repaired tetralogy of Fallot is normal until adulthood, when it becomes burdened by major complications such as cardiac arrhythmias and heart failure. Ventricular tachycardia (VT), associated with electrical conduction abnormalities in anatomical isthmuses, is the most common complication and is refractory to medical therapy. The arrhythmogenic sources can be surgically ablated during reoperations for pulmonary valve incompetence. Read More

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http://dx.doi.org/10.1093/ejcts/ezy407DOI Listing
December 2018
4 Reads

Whether Pulmonary Valve Replacement in Asymptomatic Patients With Moderate or Severe Regurgitation After Tetralogy of Fallot Repair Is Appropriate: A Case-Control Study.

J Am Heart Assoc 2019 Jan;8(1):e010689

1 Pediatric Cardiac Surgery Center National Center for Cardiovascular Disease and Fuwai Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing China.

Background Although right ventricular ( RV ) volume was significantly decreased in symptomatic patients with repaired tetralogy of Fallot ( rTOF ) after pulmonary valve replacement ( PVR ), RV size was still enlarged along with RV dysfunction. Methods and Results A prospective case-control study was conducted in a tertiary hospital; 81 asymptomatic repaired tetralogy of Fallot patients with moderate or severe pulmonary regurgitation were enrolled. The enrolled cohort was divided into 2 groups: PVR group (n=41) and medication group (n=40). Read More

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http://dx.doi.org/10.1161/JAHA.118.010689DOI Listing
January 2019
2 Reads