12,156 results match your criteria Tetralogy of Fallot


Commentary: Targeting cytokinesis failure in tetralogy of Fallot: Late to the dance?

J Thorac Cardiovasc Surg 2020 Jun 6. Epub 2020 Jun 6.

Duke Congenital Heart Research & Training Laboratory, Duke University, Durham, NC; Duke Children's Pediatric & Congenital Heart Center, Duke Children's Hospital, Durham, NC. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2020.05.077DOI Listing

Heart Failure in Adult Congenital Heart Disease.

Cardiol Clin 2020 Aug;38(3):457-469

Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98195, USA.

As the population of adult congenital heart disease patients ages and grows, so too does the burden of heart failure in this population. Despite the advances in medical and surgical therapies over the last decades, heart failure in adult congenital heart disease remains a formidable complication with high morbidity and mortality. This review focuses on the challenges in determining the true burden and management of heart failure in adult congenital heart disease. Read More

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http://dx.doi.org/10.1016/j.ccl.2020.04.010DOI Listing

Tetralogy of Fallot.

Cardiol Clin 2020 Aug 10;38(3):365-377. Epub 2020 Jun 10.

Department of Cardiology, Boston Children's Hospital, Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Bader 208, Boston, MA 02115, USA. Electronic address:

Repaired tetralogy of Fallot is one of the most common conditions managed by adult congenital heart disease providers. Recent comprehensive review articles and book chapters are devoted to this topic. The purpose of this article is to address several common clinical questions encountered in the management of patients with repaired tetralogy of Fallot. Read More

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http://dx.doi.org/10.1016/j.ccl.2020.04.009DOI Listing

An Analysis of Hospital Mortality After Cardiac Operations in Children with Down Syndrome.

Semin Thorac Cardiovasc Surg 2020 Jul 1. Epub 2020 Jul 1.

Lillie Frank Abercrombie Section of Cardiology, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.

Children with Down syndrome (DS) have lower mortality compared to non-syndromic (NS) children after atrioventricular septal defect (AVSD) repair. Limited data exist regarding hospital mortality and utilization after other congenital heart disease (CHD) operations in DS. We compared hospital mortality and utilization after CHD operations in both populations and hypothesized that the survival benefit in children with DS is not consistent across CHD lesions. Read More

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http://dx.doi.org/10.1053/j.semtcvs.2020.06.037DOI Listing

Is the Die Cast by Surgeon's Choice or Patient's Anatomy? Late Outcomes in Tetralogy of Fallot.

Can J Cardiol 2020 Apr 1. Epub 2020 Apr 1.

University of Texas Southwestern, Children's Health Dallas, Dallas, Texas, USA.

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http://dx.doi.org/10.1016/j.cjca.2020.03.039DOI Listing

[Prenatal diagnosis of a case of Pallister-Killian syndrome].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 Jul;37(7):771-773

Department of Medical Genetics and Prenatal Diagnosis, Women and Children's Health Care Hospital of Sichuan Province, Chengdu, Sichuan 610000, China.

Objective: To carry out G-banded chromosomal karyotyping and chromosomal microarray analysis (CMA) for a fetus featuring multiple malformations.

Methods: The fetus was found to have increased nuchal thickness, generalized edema, asymmetric lower limbs, tetralogy of Fallot, nasal bone anomaly and cleft palate. Following amniocentesis, G-band karyotyping and CMA were carried out. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2020.07.017DOI Listing

Induced pluripotent stem cells of patients with Tetralogy of Fallot reveal transcriptional alterations in cardiomyocyte differentiation.

Sci Rep 2020 Jul 2;10(1):10921. Epub 2020 Jul 2.

Cardiovascular Genetics, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Patient-specific induced pluripotent stem cells (ps-iPSCs) and their differentiated cell types are a powerful model system to gain insight into mechanisms driving early developmental and disease-associated regulatory networks. In this study, we use ps-iPSCs to gain insights into Tetralogy of Fallot (TOF), which represents the most common cyanotic heart defect in humans. iPSCs were generated and further differentiated to cardiomyocytes (CMs) using standard methods from two well-characterized TOF patients and their healthy relatives serving as controls. Read More

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http://dx.doi.org/10.1038/s41598-020-67872-zDOI Listing

Negative Impact of Obesity on Ventricular Size and Function and Exercise Performance in Children and Adolescents with Repaired Tetralogy of Fallot.

Can J Cardiol 2020 Jun 29. Epub 2020 Jun 29.

Division of Cardiology, Department of Pediatrics, University of Toronto, Labatt Family Heart Centre, The Hospital for Sick Children, , Toronto, Ontario, Canada. Electronic address:

Background: Up to 25% of children with congenital heart disease are obese, which may have negative physiologic consequences for patients with repaired tetralogy of Fallot (rTOF).

Methods: Patients with rTOF who underwent cardiac magnetic resonance (CMR) and cardiopulmonary exercise testing from 2007-2018 were reviewed. Complex rTOF patients were excluded. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.06.015DOI Listing

Early infant symptomatic patients with TOF-APV: Pulmonary artery management and airway stabilization.

Ann Thorac Surg 2020 Jun 29. Epub 2020 Jun 29.

Department of Cardiac Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA. Electronic address:

Background: Tracheobronchomalacia and airway obstruction from severely dilated pulmonary arteries in Tetralogy of Fallot with absent pulmonary valve (TOF-APV) has been associated with high rates of respiratory failure and mortality (15-25%). It is not known whether aggressive pulmonary artery and/or direct airway intervention during early definitive cardiac repair improves outcomes.

Methods: Retrospective observational study of all patients undergoing surgical repair for TOF-APV at our center between 2006-2018. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.05.058DOI Listing

An unusual presentation of developmental anomalies of the cardiovascular system including tetralogy of fallot, double outlet right ventricle, patent foramen ovale and persistent right aortic arch in a Friesian calf.

BMC Vet Res 2020 Jun 30;16(1):224. Epub 2020 Jun 30.

Section of Herd Health and Animal Husbandry, School of Veterinary Medicine, Veterinary Sciences Centre, University College Dublin, Belfield, Dublin 4, Ireland.

Background: Congenital heart diseases are occasionally encountered in the bovine species. Ventricular septal defects (VSD) and atrial septal defects (ASD) are reported to be the most common; however, a vast collection have been reported [1, 2]. Congenital heart diseases is thought to represent less than 3% of all congenital abnormalities in calves [3]. Read More

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http://dx.doi.org/10.1186/s12917-020-02439-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325375PMC

Experience and Outcomes of Surgically Implanted Melody Valve in the Pulmonary Position.

Ann Thorac Surg 2020 Jun 27. Epub 2020 Jun 27.

Department of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA.

Background: Multiple congenital cardiac malformations require pulmonary valve replacement (PVR) and/or right ventricular outflow (RVOT) reconstruction. PVR remains challenging in children due to limited growth potential of prosthetic valves. We evaluated our outcomes in patients undergoing surgical implantation of a Melody valve in the RVOT. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.05.061DOI Listing

Histologic Abnormalities of the Ascending Aorta: Effects on Aortic Remodeling after Intracardiac Repair of Tetralogy of Fallot.

Tex Heart Inst J 2020 Apr;47(2):86-95

Department of Cardiothoracic and Vascular Surgery, All India Institute of Medical Sciences, New Delhi 110029, India.

We evaluated aortic tissue specimens from patients undergoing tetralogy of Fallot repair, to determine whether histologic abnormalities affect postsurgical aortic remodeling and other patient-related variables. Using light microscopy, we studied full-thickness aortic wall tissue operatively excised from 118 consecutive patients undergoing intracardiac repair of tetralogy of Fallot. We performed multiple linear regression analysis to identify independent predictors of change in aortic root dimensions, which we measured with echocardiography after repair and every 3 months thereafter. Read More

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http://dx.doi.org/10.14503/THIJ-17-6279DOI Listing

Identification of miRNA-mRNA-TFs Regulatory Network and Crucial Pathways Involved in Tetralogy of Fallot.

Front Genet 2020 12;11:552. Epub 2020 Jun 12.

Department of Cardiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. However, its pathogenesis remains unknown. To explore key regulatory connections and crucial pathways underlying the TOF, gene or microRNA expression profile datasets of human TOF were obtained from the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database. Read More

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http://dx.doi.org/10.3389/fgene.2020.00552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303929PMC

Persistent left superior vena cava accompanying repaired tetralogy of Fallot: Does it pose a challenge for device implantation?

Cardiol Young 2020 Jun 29:1-2. Epub 2020 Jun 29.

Kocaeli Universitesi Tip Fakultesi - Cardiology, Kocaeli, Turkey.

Persistent left superior vena cava is a thoracic venous return anomaly. Tetralogy of Fallot is one of the most common congenital anomalies seen with persistent left superior vena cava. We are presenting a successful cardiac resynchronisation therapy device implantation in a patient with repaired tetralogy of Fallot and persistent left superior vena cava combination which has not been previously reported in the literature. Read More

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http://dx.doi.org/10.1017/S1047951120001584DOI Listing

Catastrophic Case Scenario During Percutaneous Pulmonary Valve Replacement.

J Cardiothorac Vasc Anesth 2020 May 22. Epub 2020 May 22.

Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1053/j.jvca.2020.05.019DOI Listing

Prognostic implications of inferior vena cava haemodynamics in ambulatory patients with tetralogy of Fallot.

ESC Heart Fail 2020 Jun 26. Epub 2020 Jun 26.

Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Aims: Right atrial pressure (RAP) provides a composite measure of right ventricular diastolic dysfunction, right atrial compliance, and volume status, and these three variables are typically abnormal in adults with repaired tetralogy of Fallot (TOF). RAP is a well-established prognostic metric in patients with pulmonary hypertension, and recent data suggest that RAP is associated with clinical outcomes in TOF. The purpose of this study was to determine the role of inferior vena cava (IVC) haemodynamics (size and collapsibility) for the assessment of RAP and its potential application for risk stratification and prognostication in the TOF population. Read More

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http://dx.doi.org/10.1002/ehf2.12836DOI Listing

Novel Z Scores to Correct Biases Due to Ventricular Volume Indexation to Body Surface Area in Adolescents and Young Adults.

Can J Cardiol 2020 Jun 22. Epub 2020 Jun 22.

Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada. Electronic address:

Background: Reference values for cardiac magnetic resonance imaging (cMRI) in children and young adults are scarce. This leads to risk stratification of patients with congenital heart diseases to be based on volumes indexed to body surface area (BSA). We aimed to produce cMRI Z score equations for ventricular volumes in children and young adults and test whether indexing to BSA resulted in an incorrect assessment of ventricular dilatation according to sex, body composition and growth. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.06.009DOI Listing

Implantable Cardioverter-Defibrillator Therapy to Reduce Sudden Cardiac Death in Adults with Congenital Heart Disease: A Registry Study.

J Cardiovasc Electrophysiol 2020 Jun 24. Epub 2020 Jun 24.

Department of Cardiology, University of Leeds and Leeds Teaching Hospitals NHS Trust, UK.

Introduction: The Adult Congenital Heart Disease (ACHD) population is rapidly expanding. However, a significant proportion of these patients suffer sudden cardiac death. Recommending implantable cardioverter-defibrillator (ICD) insertion requires balancing need for appropriate therapy in malignant arrhythmia against the consequences of inappropriate therapy and procedural complications. Read More

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http://dx.doi.org/10.1111/jce.14633DOI Listing

Successful surgical correction of tetralogy of fallot associated with anomalous left coronary artery connection to pulmonary artery.

Cardiol Young 2020 Jun 25:1-4. Epub 2020 Jun 25.

Department of Cardiothoracic surgery, All India Institute of Medical Sciences, New Delhi, India.

Tetralogy of fallot is rarely associated with anomalous left coronary artery connection to main pulmonary artery. High index of suspicion is needed preoperatively to diagnose this association and treat successfully. We present a case of 9-year-old boy with the rare association of tetralogy of fallot and anomalous left coronary artery connection to pulmonary artery with a giant steal intercoronary collateral crossing right ventricular outflow tract who was treated successfully by single-stage surgical correction. Read More

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http://dx.doi.org/10.1017/S1047951120001730DOI Listing

Initial experience with Edwards SAPIEN valve transcatheter implantation in native RVOT in Latvia.

Acta Med Litu 2020 ;27(1):10-16

Children's Clinical University Hospital, Department of Paediatric Cardiology and Cardiac Surgery, Riga, Latvia.

Transcatheter pulmonary valve implantation has been a well-known method for more than a decade, but there are still many challenging cases when a personalized solution is needed. We report a case of a 15-year-old female patient with tetralogy of Fallot, who underwent a  surgical correction during infancy. Because of progressive pulmonary regurgitation, stenosis, and right ventricle dilatation, transcatheter pulmonary valve implantation in the native right ventricle outflow tract (RVOT) using Edwards SAPIEN valve was performed. Read More

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http://dx.doi.org/10.6001/actamedica.v27i1.4261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305804PMC
January 2020

Case report: inflammatory pseudotumor in the lung parenchyma caused by a medical suture originating from a cardiac surgery 35 years ago.

J Cardiothorac Surg 2020 Jun 23;15(1):151. Epub 2020 Jun 23.

Department of Thoracic Surgery, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing, 100044, China.

Background: The incidence of the iatrogenic foreign body retained after surgery is extremely low. Iatrogenic foreign body retained is surrounded by normal tissue, which responds to foreign matter to form inflammatory pseudotumors. Surgical sponge or swap is the most common type of foreign body. Read More

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http://dx.doi.org/10.1186/s13019-020-01194-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313219PMC

Ascending aortic aneurysm associated with tetralogy of Fallot in an adult mare.

Vet Med Sci 2020 Jun 23. Epub 2020 Jun 23.

University Teaching Hospital, Sydney School of Veterinary Science, University of Sydney, Camden, New South Wales, Australia.

Congenital heart disease is relatively uncommon in horses. Only three reports exist that describe a tetralogy of Fallot in adult horses. Whereas in humans the presence of congenital heart disease constitutes a risk factor for developing aortic aneurysms, their association has never been reported in horses. Read More

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http://dx.doi.org/10.1002/vms3.311DOI Listing

From Other Journals: A Review of Recent Articles in Pediatric Cardiology.

Authors:
Tarek Alsaied

Pediatr Cardiol 2020 Jun 23. Epub 2020 Jun 23.

Heart Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.

In this review, we provide a brief description of recently published articles addressing topics relevant to pediatric cardiologists. Our hope is to provide a summary of the latest articles published recently in other journals in our field. The articles address the following: (1) transcatheter closure of sinus venous atrial septal defect which is feasible in adults with careful planning, (2) exercise echocardiography in children with hypertrophic cardiomyopathy which was found to be very helpful to identify low-risk patients when there is no gradient at rest or during exercise, (3) features of Fontan patients with normal exercise capacity who typically report more active life style and have less complications during the post-Fontan admissions, (4) the natural history of Anderson-Tawil syndrome which is characterized by high incidence of life-threatening arrhythmogenic events especially when there is history of syncope, ventricular tachycardia, or the use of amiodarone, (5) pulmonary artery banding in complete atrioventricular septal defects which were found to be a safe alternative to early complete repair and served as a bridge to biventricular repair with variable effect on common atrioventricular valve regurgitation and (6) tricuspid valve interventions (TVI) in patients undergoing pulmonary valve replacement (PVR) which further reduce tricuspid regurgitation beyond what is expected in PVR alone without increasing early complications or hospital length of stay. Read More

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http://dx.doi.org/10.1007/s00246-020-02404-0DOI Listing

Wharton's Jelly-Mesenchymal Stem Cells- engineered conduit for pediatric translation in Heart Defect.

Tissue Eng Part A 2020 Jun 22. Epub 2020 Jun 22.

University of Bristol School of Clinical Science, 156599, Bristol, United Kingdom of Great Britain and Northern Ireland, BS2 8AE;

The materials available for the Right Ventricular Outflow Tract (RVOT) reconstruction in patients with Tetralogy of Fallot (TOF)/pulmonary atresia come with the severe limitation of long-term degeneration and lack of growth potential, causing right ventricular dysfunction, aneurysm formation and arrhythmias, thus necessitating several high-risk reoperations throughout patients' life. In this study, we evaluated the capacity of Mesenchymal Stem Cells (MSCs) derived from the Wharton's Jelly (WJ-MSCs), the gelatinous inner portion of the umbilical cord, to grow and recellularize an extracellular matrix (ECM) graft in our optimised xeno-free, good manufacturing practice- compliant culture system. WJ-MSCs were phenotypically and functionally characterised by flow cytometry and multi-lineage differentiation capacity, respectively. Read More

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http://dx.doi.org/10.1089/ten.TEA.2020.0088DOI Listing

A rare case of tympanostomy tube otorrhea: Pigmentiphaga.

Int J Pediatr Otorhinolaryngol 2020 Jun 4;136:110165. Epub 2020 Jun 4.

Department of Otolaryngology and Communication Disorders, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address:

Tympanostomy tube otorrhea (TTO) is a common complication of tympanostomy tubes. The most common bacteria associated with TTO include Haemophalis influenza, Moraxella catarrhalis, Streptococcus pneumoniae, Staphylococcus aureus, and Pseudomonas aeruginosa. We present the first case of a 9 year-old female with a history of 22q11 syndrome, hemifacial microsomia, Tetralogy of Fallot, and hearing aid dependence with left-sided profound sensorineural and right-sided moderate conductive hearing loss who presented with TTO caused by the bacteria Pigmentiphaga daeguenesis/kulla, a gram-negative bacteria often found in soil. Read More

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http://dx.doi.org/10.1016/j.ijporl.2020.110165DOI Listing

Intraoperative Conundrum Between Hepatic Vein and Partial Anomalous Pulmonary Vein Connection in a Case of Tetralogy of Fallot With Persistent Left Superior Vena Cava.

J Cardiothorac Vasc Anesth 2020 May 21. Epub 2020 May 21.

Department of Cardiology, Cardiothoracic Centre, CNC, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.

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http://dx.doi.org/10.1053/j.jvca.2020.05.011DOI Listing

Unrepaired Tetralogy of Fallot in Adulthood.

N Engl J Med 2020 Jun;382(25):e97

University of Massachusetts Medical School, Worcester, MA

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http://dx.doi.org/10.1056/NEJMicm1912128DOI Listing

Partial anomalous pulmonary venous connection in a patient with tetralogy of Fallot: Infrequent, but not inconsequential.

J Card Surg 2020 Jun 19. Epub 2020 Jun 19.

Department of Cardiovascular Radiology and Endovascular Interventions, All India Institute of Medical Sciences, New Delhi, India.

We hereby describe a rare case of partial anomalous pulmonary venous connection (PAPVC) in a patient with tetralogy of Fallot (TOF). It is imperative to identify PAPVC preoperatively in patients with TOF as it can have significant hemodynamic outcomes. This case highlights the importance of computed tomography angiography in demonstrating the same. Read More

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http://dx.doi.org/10.1111/jocs.14697DOI Listing
June 2020
0.888 Impact Factor

His-Bundle Pacing From the Right Atrium in a Patient With Tetralogy of Fallot and a Prosthetic Tricuspid Valve.

JACC Clin Electrophysiol 2020 Jun;6(6):745-746

Division of Cardiac Electrophysiology, Virgen de las Nieves University Hospital, Granada, Spain.

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http://dx.doi.org/10.1016/j.jacep.2020.03.011DOI Listing

Right Ventricular Basal Aneurysm as a Substrate for Ventricular Tachycardia in Tetralogy of Fallot.

JACC Clin Electrophysiol 2020 Jun;6(6):743-744

Montreal Heart Institute, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jacep.2020.03.007DOI Listing

3D-printing in preoperative planning in neonates with complex congenital heart defects.

J Matern Fetal Neonatal Med 2020 Jun 18:1-5. Epub 2020 Jun 18.

Almazov National Medical Research Centre, Institute of Perinatology and Pediatrics, Saint-Petersburg, Russian Federation.

The application of the 3D printing approach in medicine is currently becoming increasingly popular. The management of fetuses and newborns with congenital heart defects is often difficult, primarily due to the complexity of the anatomy. Here we report a newborn with a complex congenital malformation (absent pulmonary valve syndrome associated with tetralogy of Fallot), which could be clinically interpreted in different ways. Read More

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http://dx.doi.org/10.1080/14767058.2020.1771691DOI Listing

Predictors of a complicated course after surgical repair of tetralogy of Fallot.

Turk Gogus Kalp Damar Cerrahisi Derg 2019 Jun 22;28(2):264-273. Epub 2020 Apr 22.

Department of Pediatric Cardiovascular Surgery, Mehmet Akif Ersoy Thoracic and Cardiovascular Training and Research Hospital, Istanbul, Turkey.

Background: In this study, we aimed to evaluate the patient and surgical factors affecting prolonged hospital stay and major adverse events after surgical repair of tetralogy of Fallot and to identify the predictors of a complicated course after surgical repair.

Methods: A total of 170 consecutive patients (96 males, 74 females; median age 12 months; range, 1 to 192 months) who underwent surgical repair of tetralogy of Fallot between January 2015 and April 2018 were retrospectively reviewed. A mechanical ventilation duration of >24 h, an intensive care unit stay of >3 days, and a hospital stay of >7 days were considered as prolonged. Read More

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http://dx.doi.org/10.5606/tgkdc.dergisi.2020.18829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298368PMC

Adult Congenital Heart Disease Outpatient Clinic. Descriptive Analysis of A 12-Year Experience in Brazil.

Braz J Cardiovasc Surg 2020 Jun 1;35(3):254-264. Epub 2020 Jun 1.

Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto Department of Internal Medicine Ribeirão Preto SP Brazil Cardiology Center of the Department of Internal Medicine, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.

Objective: Description of adult congenital heart disease (CHD) outpatient characteristics has not been reported and several aspects regarding these patients require attention. We describe the 12-year experience of a Brazilian unit.

Methods: The main characteristics of 1168 patients were reviewed annotating for each patient age, gender, city of residence, main diagnosis, functional class at last examination, defect complexity and in-hospital referral pattern. Read More

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http://dx.doi.org/10.21470/1678-9741-2019-0047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299597PMC

The Population Prevalence, Associations of Congenital Heart Defect and Mortality Risk for Down's Syndrome in South Korea Based on National Health Insurance Service (NHIS) Data.

Clin Epidemiol 2020 27;12:519-525. Epub 2020 May 27.

Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: In the present study, we estimated the population prevalence, associations of congenital heart defect (CHD) and mortality risk for DS using data from National Health Insurance Service (NHIS) and Rare Diseases Registry (RDR).

Methods: We collected data on subjects with DS who were registered in the RDR between 2010 and 2015. To estimate associations of CHD and mortality risk of DS, the data of DS subjects were compared with 1:5 age- and sex-matched controls. Read More

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http://dx.doi.org/10.2147/CLEP.S251637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266305PMC

Gene-environment regulation of chamber-specific maturation during hypoxemic perinatal circulatory transition.

J Mol Med (Berl) 2020 Jun 12. Epub 2020 Jun 12.

Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles 675 Charles E. Young Dr S, 3762 MacDonald Research Laboratories, Los Angeles, CA, 90024, USA.

Chamber-specific and temporally regulated perinatal cardiac growth and maturation is critical for functional adaptation of the heart and may be altered significantly in response to perinatal stress, such as systemic hypoxia (hypoxemia), leading to significant pathology, even mortality. Understanding transcriptome regulation of neonatal heart chambers in response to hypoxemia is necessary to develop chamber-specific therapies for infants with cyanotic congenital heart defects (CHDs). We sought to determine chamber-specific transcriptome programming during hypoxemic perinatal circulatory transition. Read More

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http://dx.doi.org/10.1007/s00109-020-01933-8DOI Listing

Continuous infusion with octocog alfa during cardiac surgery for tetralogy of Fallot in a haemophilic child.

Blood Transfus 2020 Jun 4. Epub 2020 Jun 4.

Paediatric Section, Department of Biomedicine and Human Oncology, "A. Moro" University, Bari.

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http://dx.doi.org/10.2450/2020.0030-20DOI Listing

Three-Year Outcomes From the Harmony Native Outflow Tract Early Feasibility Study.

Circ Cardiovasc Interv 2020 Jan 9;13(1):e008320. Epub 2020 Jan 9.

Nationwide Children's Hospital, Columbus, OH (S.L.C., K.N.H., J.P.C.).

Background: The Harmony transcatheter pulmonary valve (TPV) was designed for treatment of postoperative pulmonary valve regurgitation in patients with repaired right ventricular outflow tracts.

Methods: The Native TPV EFS (Early Feasibility Study) is a prospective, multicenter, nonrandomized feasibility study. Three-year outcomes are reported. Read More

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.008320DOI Listing
January 2020

Degenerated conduit post tetralogy of Fallot repair presenting as pulsatile subcutaneous swelling.

Ann Thorac Surg 2020 Jun 7. Epub 2020 Jun 7.

Department of Cardiovascular Radiology & Endovascular Interventions, All India Institute of Medical Sciences, New Delhi-110029, India. Electronic address:

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http://dx.doi.org/10.1016/j.athoracsur.2020.04.095DOI Listing
June 2020
3.849 Impact Factor

First reported case of unrepaired tetralogy of Fallot complicated with coronavirus disease-19 (COVID-19).

Cardiol Young 2020 Jun 11:1-4. Epub 2020 Jun 11.

Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.

The incidence of novel coronavirus disease-19 (nCoV-19) and its associated complications is higher in high-risk groups. In this article, we explain the symptoms and course of the disease and the treatment for an adult patient with CHD who has been infected with novel nCoV-19. Read More

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http://dx.doi.org/10.1017/S1047951120001821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308621PMC

Differences in right ventricular-pulmonary vascular coupling and clinical indices between repaired standard tetralogy of Fallot and repaired tetralogy of Fallot with pulmonary atresia.

Diagn Interv Imaging 2020 Jun 5. Epub 2020 Jun 5.

Blalock Taussig Thomas Heart Center, The Johns Hopkins Hospital and School of Medicine, 1800 Orleans St, 21287 Baltimore, MD, USA. Electronic address:

Purpose: The purpose of this study was to compare ventricular vascular coupling ratio (VVCR) between patients with repaired standard tetralogy of Fallot (TOF) and those with repaired TOF-pulmonary atresia (TOF-PA) using cardiovascular magnetic resonance (CMR).

Materials And Methods: Patients with repaired TOF aged>6 years were prospectively enrolled for same day CMR, echocardiography, and exercise stress test following a standardized protocol. Sanz's method was used to calculate VVCR as right ventricle (RV) end-systolic volume/pulmonary artery stroke volume. Read More

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http://dx.doi.org/10.1016/j.diii.2020.05.008DOI Listing

Total Transcatheter Correction of Tetralogy of Fallot.

Pediatr Cardiol 2020 Jun 6;41(5):1076-1077. Epub 2020 Jun 6.

McGovern Medical School, University of Texas at Houston, Houston, TX, USA.

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http://dx.doi.org/10.1007/s00246-020-02389-wDOI Listing

Low threshold for intracranial imaging in fever of unknown origin associated with cyanotic heart disease in the pediatric population.

Childs Nerv Syst 2020 Jun 6. Epub 2020 Jun 6.

Department of Neurosurgery, Boston Children's Hospital, Harvard University, Boston, MA, USA.

Intracranial abscess in the pediatric population is an overall rare occurrence-4 in a million. The most common predisposing factor is underlying cyanotic congenital heart disease (CCHD), which is associated with ~ 30% of all cases. We present an unusual case of cerebral abscess in a 17-month-old female with partially treated Tetralogy of Fallot and fever of unknown origin without associated neurologic symptoms. Read More

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http://dx.doi.org/10.1007/s00381-020-04696-2DOI Listing

Effect of single-dose crystalloid cardioplegic agent compared to bloody cardioplegic agent in cardiac surgery in children with Tetralogy of Fallot.

ARYA Atheroscler 2020 Jan;16(1):24-32

Assistant Professor, Department of Cardiac Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Cardioplegia is one of the main post-operative cardiac protective factors widely used in recent decades in the form of crystalloid (St. Thomas) and bloody solutions [del Nido (DN)]. The purpose of this study was to compare the effect of a crystalloid cardioplegic agent (St. Read More

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http://dx.doi.org/10.22122/arya.v16i1.1943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244793PMC
January 2020

Defibrillators in adult congenital heart disease: Long-term risk of appropriate shocks, inappropriate shocks, and complications.

Pacing Clin Electrophysiol 2020 Jun 4. Epub 2020 Jun 4.

Sydney Medical School, The University of Sydney, Camperdown, Australia.

Aims: Sudden cardiac death (SCD) accounts for up to 25% of deaths in the adult congenital heart disease (ACHD) population. Current guidelines for defibrillator implantation are either extrapolated from acquired cardiac disease or are based upon single lesion studies, predominantly Tetralogy of Fallot (TOF). Defibrillator-related morbidity appears to be substantially higher in ACHD patients. Read More

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http://dx.doi.org/10.1111/pace.13974DOI Listing

Inappropriate implantable cardioverter-defibrillator shocks in repaired tetralogy of fallot patients: Prevalence and electrophysiological mechanisms.

Int J Cardiol Heart Vasc 2020 Jun 26;28:100543. Epub 2020 May 26.

Internal Medicine, Division of Cardiology, Columbia University Irving Medical Center, 622 W 168th St, New York, NY 10032, USA.

Background: Patients with Tetralogy of Fallot (TOF) are at increased risk for sudden cardiac death, often undergo implantable cardioverter defibrillator (ICD) implantation at younger ages, and are at greater risk of experiencing inappropriate shocks. We investigated occurrences of ICD shocks in TOF patients to identify prevalence, characteristics associated with inappropriate shocks, and therapeutic interventions after inappropriate shocks.

Methods: Records of patients with repaired TOF and ICD implantation who were followed at Columbia University Irving Medical Center between 1/1/2000 and 5/1/2019 were analyzed. Read More

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http://dx.doi.org/10.1016/j.ijcha.2020.100543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256636PMC

Prenatal screening of DiGeorge (22q11.2 deletion) syndrome by abnormalities of the great arteries among Thai pregnant women.

Obstet Gynecol Sci 2020 May 14;63(3):330-336. Epub 2020 Apr 14.

Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Objective: 22q11.2DS (deletion syndrome) is one of the common serious anomalies resulting in high perinatal morbidity and mortality rate. Nevertheless, prenatal diagnosis of 22q11. Read More

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http://dx.doi.org/10.5468/ogs.2020.63.3.330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231935PMC

Pulmonary artery hemodynamic assessment of blood flow characteristics in repaired tetralogy of Fallot patients versus healthy child volunteers.

Quant Imaging Med Surg 2020 May;10(5):921-933

Diagnostic Imaging Center, Shanghai Children's Medical Center Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

Background: This study aimed to assess the severity of helix and vortex flow in pulmonary artery hemodynamic using 4-dimensional flow cardiac magnetic resonance (4D flow CMR) in patients with repaired tetralogy of Fallot (rTOF) and healthy child volunteers and to explore the relationship between pulmonary hemodynamic changes and right heart function.

Methods: CMR studies were performed in 25 rTOF patients (15 M/10 F; 8.44±4. Read More

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http://dx.doi.org/10.21037/qims.2020.03.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242295PMC

Anaesthesia concerns and perioperative management in a child with DiGeorge syndrome with corrected tetralogy of Fallot with pulmonary atresia posted for laparoscopic orchidopexy: Case report.

Indian J Anaesth 2020 Apr 28;64(4):322-324. Epub 2020 Mar 28.

Department of Anaesthesiology and Paediatric Cardiac Sciences, Sir H. N. Reliance Hospital, Mumbai, Maharashtra, India.

DiGeorge syndrome is afflicted with multiple congenital anomalies such as conotruncal and craniofacial anomaly, immune system dysfunction and hypoplasia/aplasia of parathyroid glands. Laparoscopy is a preferred surgical approach over open orchidopexy due to better visualisation of impalpable testis avoiding long incision, minimal tissue damage and a faster recovery. We report a case of DiGeorge syndrome with corrected tetralogy of Fallot with pulmonary atresia in a 1-year-old male child posted for laparoscopic orchidopexy. Read More

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http://dx.doi.org/10.4103/ija.IJA_770_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259404PMC