11,605 results match your criteria Tetralogy of Fallot


Factors associated with health-related quality of life among adults with tetralogy of Fallot.

Open Heart 2019 27;6(1):e000932. Epub 2019 Feb 27.

Heart Centre and Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.

Background: Due to improved care, the numbers of patients with tetralogy of Fallot (ToF) are increasing. However, long-term morbidity and need for reinterventions are concerns and also address issues of quality of life (QoL).

Methods: Patients with ToF and valid EuroQol-5 dimensions questionnaire (EQ-5D) were identified in the national Swedish register on congenital heart disease. Read More

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http://dx.doi.org/10.1136/openhrt-2018-000932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443137PMC
February 2019

Focal scar and diffuse myocardial fibrosis are independent imaging markers in repaired tetralogy of Fallot.

Eur Heart J Cardiovasc Imaging 2019 Apr 16. Epub 2019 Apr 16.

Department of Cardiovascular Imaging, Hôpital Cardiologique du Haut-Lévêque, CHU de Bordeaux, Avenue de Magellan, 33604 Pessac, France.

Aims: To identify the correlates of focal scar and diffuse fibrosis in patients with history of tetralogy of Fallot (TOF) repair.

Methods And Results: Consecutive patients with prior TOF repair underwent electrocardiogram, 24-h Holter, transthoracic echocardiography, exercise testing, and cardiac magnetic resonance (CMR) including cine imaging to assess ventricular volumes and ejection fraction, T1 mapping to assess left ventricular (LV) and right ventricular (RV) diffuse fibrosis, and free-breathing late gadolinium-enhanced imaging to quantify scar area at high spatial resolution. Structural imaging data were related to clinical characteristics and functional imaging markers. Read More

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http://dx.doi.org/10.1093/ehjci/jez068DOI Listing

Cardiac Resynchronization Therapy for Treatment of Chronic Subpulmonary Right Ventricular Dysfunction in Congenital Heart Disease.

Circ Arrhythm Electrophysiol 2019 May;12(5):e007157

Children's Heart Center, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Czech Republic (J.J., J.K., M.L., V.T., R.G., P.K.).

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http://dx.doi.org/10.1161/CIRCEP.119.007157DOI Listing

Serial assessment of postoperative ventricular mechanics in young children with tetralogy of Fallot: Comparison of transannular patch and valve-sparing repair.

Congenit Heart Dis 2019 Apr 15. Epub 2019 Apr 15.

Division of Pediatric Cardiothoracic Surgery, Betty Irene Moore Heart Center Clinical and Translational Research Program, Lucile Packard Children's Hospital, Stanford University Medical Center, Palo Alto, California.

Background: Little is known about the early time course of biventricular function and mechanics after tetralogy of Fallot (TOF) repair. We sought to evaluate and describe the evolution of the right ventricle (RV) after TOF repair in young infants and children using conventional echocardiographic parameters and global longitudinal strain (GLS).

Methods: A retrospective review was performed of all patients with TOF and pulmonary stenosis who underwent repair from January 2002 to September 2015 and had at least 3 serial postsurgical echocardiograms spanning from infancy to early childhood (<8 years). Read More

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http://dx.doi.org/10.1111/chd.12772DOI Listing

Right ventricular remodeling after conduit replacement in patients with corrected tetralogy of Fallot - evaluation by cardiac magnetic resonance.

J Cardiothorac Surg 2019 Apr 15;14(1):77. Epub 2019 Apr 15.

Department of Cardiothoracic Surgery, Clinical sciences, Lund University, Skane University Hospital, SE-221 85, Lund, Sweden.

Purpose: To evaluate the potential for right ventricular reverse remodelling after pulmonary valve replacement using cardiac magnetic resonance imaging, in adults with corrected tetralogy of Fallot and severe pulmonary insufficiency.

Material And Methods: Ten patients with previous correction of tetralogy of Fallot with severe pulmonary insufficiency accepted for pulmonary valve replacement were evaluated prospectively with cardiac magnetic resonance imaging preoperatively and re-evaluated 10 ± 5 months postoperatively. Follow up for survival was 100% complete with mean of 37 ± 12 months. Read More

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http://dx.doi.org/10.1186/s13019-019-0899-6DOI Listing

Management of Congenital Heart Disease: State of the Art-Part II-Cyanotic Heart Defects.

Children (Basel) 2019 Apr 4;6(4). Epub 2019 Apr 4.

University of Texas-Houston McGovern Medical School, Children's Memorial Hermann Hospital, Houston, TX 77030, USA.

In this review management of the most common cyanotic congenital heart defects (CHDs) was discussed; the management of acyanotic CHD was reviewed in Part I of this series. While the need for intervention in acyanotic CHD is by and large determined by the severity of the lesion, most cyanotic CHDs require intervention, mostly by surgery. Different types of tetralogy of Fallot require different types of total surgical corrective procedures, and some may require initial palliation, mainly by modified Blalock-Taussig shunts. Read More

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http://dx.doi.org/10.3390/children6040054DOI Listing

Problem-Based Learning Discussion on Neuraxial Anesthesia in Parturients With Repaired Tetralogy of Fallot.

MedEdPORTAL 2016 Nov 3;12:10491. Epub 2016 Nov 3.

Assistant Professor, Department of Anesthesiology, Wayne State University School of Medicine.

Introduction: Approximately 1% of all children born in the United States suffer from congenital heart disease, and 25% of those affected are born with critical congenital heart disease requiring surgical intervention. Advances in cardiac surgery have allowed an increasing number of patients with complex congenital heart disease to live into adulthood. It is important that anesthesiologists understand the particularities of providing safe clinical care for these patients in different situations. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440416PMC
November 2016

Cervical ganglioneuroma: A case report and review of the literature.

Medicine (Baltimore) 2019 Apr;98(15):e15203

Department of Otolaryngology-Head and Neck Surgery, First Hospital of Jilin University, Jilin University, Changchun 130021, Jilin Province, China.

Rationale: Ganglioneuromas are benign neoplasm of neuroblastic origin which arise from central or peripheral parts of the autonomic nervous system. They are normally found at posterior mediastinum, retroperitoneum, and the adrenal gland but ganglioneuromas are rarely found in the cervical region.

Patient Concerns: A 12-year-old boy was admitted with a left-lateral neck mass slow growing over a 7-days duration. Read More

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http://dx.doi.org/10.1097/MD.0000000000015203DOI Listing
April 2019
1 Read

Outcomes After Aortopulmonary Window for Hypoplastic Pulmonary Arteries and Dual-Supply Collaterals.

Ann Thorac Surg 2019 Apr 10. Epub 2019 Apr 10.

Cardiothoracic Surgery.

Background: Our institutional approach to tetralogy of Fallot (TOF) with major aortopulmonary collateral arteries (MAPCAs) emphasizes early unifocalization and complete repair (CR). In the small subset of patients with dual-supply MAPCAs and confluent but hypoplastic central pulmonary arteries (PAs), our surgical approach is early creation of an aortopulmonary window (APW) to promote PA growth. Factors associated with successful progression to CR, and mid-term outcomes have not been assessed. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.03.022DOI Listing

Placental DNA methylation changes for the detection of tetralogy of Fallot.

Ultrasound Obstet Gynecol 2019 Apr 12. Epub 2019 Apr 12.

Department of Obstetrics and Gynecology, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA.

Objectives: To determine whether the methylation level of cytosine nucleotides in placental DNA can be used to predict Tetralogy of Fallot (TOF) and provide insights into its mechanism of development.

Methods: The Illumina HumanMethylation450 BeadChips assay was used to measure cytosine ('CpG' or 'cg') methylation (i.e. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/uog.20292
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http://dx.doi.org/10.1002/uog.20292DOI Listing
April 2019
6 Reads

Fetal Heart Defects and Measures of Cerebral Size.

J Pediatr 2019 Apr 5. Epub 2019 Apr 5.

Cardiothoracic Research Department T, Aarhus University Hospital, Aarhus, Denmark.

Objectives: To estimate the association between fetal congenital heart defects (CHDs) and measures of brain size throughout pregnancy, from the end of the first trimester to birth.

Study Design: The cohort consisted of all fetuses scanned in Western Denmark in 2012 and 2013. Anthropometric measures in fetuses with isolated CHDs diagnosed within 12 months after birth were compared with those in the fetuses without CHDs. Read More

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http://dx.doi.org/10.1016/j.jpeds.2019.02.042DOI Listing
April 2019
1 Read

Cardiac Implantable Electronic Devices in Adults with Tetralogy of Fallot.

Am J Cardiol 2019 Mar 16. Epub 2019 Mar 16.

Department of Cardiovascular Medicine, Mayo Clinic Rochester, Minnesota.

Patient with repaired tetralogy of Fallot (TOF) sometimes require cardiac implantable electronic devices (CIED) for tachy/bradyarrhythmias. There are no population-based studies of CIED-related outcomes in the adult TOF population. We reviewed the Nationwide/National Inpatient Sample to determine trends in CIED-related admissions in adults with TOF repair. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149193030
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http://dx.doi.org/10.1016/j.amjcard.2019.03.010DOI Listing
March 2019
2 Reads
3.276 Impact Factor

Tetralogy of Fallot in Spain: a nationwide registry-based mortality study across 36 years.

Orphanet J Rare Dis 2019 Apr 8;14(1):79. Epub 2019 Apr 8.

Institute of Rare Diseases Research (IIER), Instituto de Salud Carlos III, 28029, Madrid, Spain.

Background: Tetralogy of Fallot (TOF) is the most frequent cyanotic congenital heart defect. TOF mortality has fallen remarkably in recent years due to therapeutic advances. Accordingly, the aim of this study was to assess temporal and spatial variability in TOF-related mortality in Spain across the period 1981-2016, using data drawn from the nationwide population-based registry. Read More

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http://dx.doi.org/10.1186/s13023-019-1056-yDOI Listing
April 2019
1 Read

Right ventricular and pulmonary vascular function indices for risk stratification of patients with pulmonary regurgitation.

Congenit Heart Dis 2019 Apr 8. Epub 2019 Apr 8.

Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota.

Background: We hypothesized that echocardiographic indices of right ventricular to pulmonary artery (RV-PA) coupling were comparable to cardiac magnetic resonance imaging (CMRI)-derived RV volumetric indices in predicting disease severity in chronic pulmonary regurgitation (PR).

Methods: Patients with ≥ moderate PR (2003-2015) with and without prior CMRI scans were enrolled into the study cohort and validation cohort, respectively. Endpoint was to determine the association between noninvasive RV-PA coupling indices (tricuspid annular plane systolic excursion/right ventricular systolic pressure [TAPSE/RVSP] and fractional area change [FAC]/RVSP ratio) and markers of disease severity, and compared this association to that of CMRI-derived RV volumetric indices and markers of disease severity (peak oxygen consumption [VO ], NT-proBNP and atrial and/or ventricular arrhythmias). Read More

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http://dx.doi.org/10.1111/chd.12768DOI Listing
April 2019
7 Reads

Different Responses to Drug Safety Screening Targets between Human Neonatal and Infantile Heart Tissue and Cardiac Bodies Derived from Human-Induced Pluripotent Stem Cells.

Stem Cells Int 2019 6;2019:6096294. Epub 2019 Mar 6.

Department of Paediatric Cardiology, Heart Centre Cologne, University Hospital of Cologne, Kerpener Str. 52, 50924 Cologne, Germany.

Aims: Induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs) have become a promising tool in cardiovascular safety pharmacology. Immaturity of iPS-CMs remains an ongoing concern. We compared electrophysiological and contractile features of cardiac bodies (hiPS-CBs) derived from human-induced pluripotent stem cells and human neonatal and infantile myocardial slices relevant for drug screening. Read More

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http://dx.doi.org/10.1155/2019/6096294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431377PMC
March 2019
1 Read

Tricuspid Valve Imaging and Intervention in Pediatric and Adult Patients With Congenital Heart Disease.

JACC Cardiovasc Imaging 2019 Apr;12(4):637-651

Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota; Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota. Electronic address:

Tricuspid valve abnormalities in congenital heart disease comprise a wide spectrum, with the most common being Ebstein anomaly and tricuspid valve dysplasia. Tricuspid valve dysfunction may also be secondary to other types of congenital heart disease, including functional tricuspid regurgitation seen in right heart volume overload conditions, such as atrial septal defect and repaired tetralogy of Fallot with severe pulmonary valve regurgitation. Congenitally corrected transposition and Mustard and Senning procedures maintain the right ventricle as the systemic ventricle, and the tricuspid valve is subject to unique hemodynamic stress not typically seen in normal circulation. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.10.036DOI Listing
April 2019
1 Read

3D-assessment of RVOT dimensions prior percutaneous pulmonary valve implantation: comparison of contrast-enhanced magnetic resonance angiography versus 3D steady-state free precession sequence.

Int J Cardiovasc Imaging 2019 Apr 1. Epub 2019 Apr 1.

Department of Diagnostic and Interventional Radiology, University of Leipzig - Heart Centre, Strümpellstrasse 39, 04289, Leipzig, Germany.

To compare contrast-enhanced magnetic resonance angiography (ceMRA) and 3D steady-state free precession (SSFP) during systole and diastole for assessment of the right ventricle outflow tract (RVOT) in patients considered for percutaneous pulmonary valve implantation (PPVI) after tetralogy of Fallot (TOF) repair. We retrospectively evaluated 89 patients (male: 45, mean age 19 ± 8 years), who underwent cardiac-MRI after surgical TOF-repair. Datasets covering the whole heart in systole and diastole were acquired using ECG-gated 3D SSFP and non-gated ceMRA. Read More

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http://link.springer.com/10.1007/s10554-019-01578-w
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http://dx.doi.org/10.1007/s10554-019-01578-wDOI Listing
April 2019
8 Reads

HDAC8 Loss of Function and SHOX Haploinsufficiency: Two Independent Genetic Defects Responsible for a Complex Phenotype.

Cytogenet Genome Res 2018 Mar 26. Epub 2018 Mar 26.

We report a patient with developmental delay, brachydactyly type E, short stature, and tetralogy of Fallot. Brachydactyly-mental retardation syndrome (BDMR) was suspected based on the phenotype; however, array CGH excluded a 2q37 deletion, but identified a deletion encompassing the SHOX gene. BDMR is characterized by cognitive impairment, skeletal abnormalities involving hands and feet, short stature, and overweight. Read More

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http://dx.doi.org/10.1159/000499174DOI Listing
March 2018
3 Reads

Determination of dynamic thiol/disulphide homeostasis in children with tetralogy of Fallot and ventricular septal defect.

Cardiol Young 2019 Apr 1:1-6. Epub 2019 Apr 1.

Department of Medical Pharmacology, Faculty of Medicine, University of Gaziantep,Gaziantep,Turkey.

Oxidative stress may contribute to the pathogenesis of congenital heart defects, but the role of dynamic thiol/disulphide homeostasis has not been evaluated. The objective of this study was to assess whether there are changes in thiol/disulphide homeostasis and nitric oxide levels in children with tetralogy of Fallot (TOF) and ventricular septal defect (VSD). A total of 47 children with congenital heart defects (24 TOF and 23 VSD) and 47 healthy age- and sex-matched controls were included in this study. Read More

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http://dx.doi.org/10.1017/S104795111900012XDOI Listing
April 2019
1 Read

Healthcare needs and quality of life in youths with congenital heart disease: Health-promoting behaviors as a mediator.

J Pediatr Nurs 2019 Mar 27. Epub 2019 Mar 27.

School of Nursing, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Purpose: The aims of this study were to examine the relationship between healthcare needs, health-promoting behaviors and quality of life (QoL) of youths with congenital heart disease (CHD), and to determine whether health-promoting behaviors were a mediating variable.

Design And Methods: This cross-sectional descriptive study was conducted recruiting 205 youths aged 15 to 24 with either ventricular septal defect (VSD) or tetralogy of Fallot (TOF). A self-reported questionnaire was used to collect demographic information; furthermore, the thickness of the triceps skinfold was measured. Read More

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http://dx.doi.org/10.1016/j.pedn.2019.03.011DOI Listing
March 2019
4 Reads

DGCR8 expression is altered in children with congenital heart defects.

Clin Chim Acta 2019 Mar 26;495:25-28. Epub 2019 Mar 26.

Henan Provincial People's Hospital, School of Clinical Medicine, Henan University, Zhengzhou, Henan 450003, PR China. Electronic address:

Aim: To explore the correlation of DGCR8 expression in children with congenital heart defects (CHD) and its clinical significance.

Methods: Full blood samples were collected from children with congenital heart disease(n = 40) and healthy children(n = 40), respectively.Real-time PCR was used to detect the expression of DGCR8 in the blood of healthy children and CHD. Read More

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http://dx.doi.org/10.1016/j.cca.2019.03.1619DOI Listing
March 2019
2 Reads

Two-stage approach for surgical treatment of tetralogy of Fallot in underweight children: Clinical and morphological outcomes.

J Card Surg 2019 Mar 29. Epub 2019 Mar 29.

Division of Experimental and Clinical Cardiology, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation.

Background: Two-stage surgery including right ventricular outflow tract (RVOT) stenting with subsequent total surgical repair (TSG) has been suggested as a promising curative option in infants with tetralogy of Fallot (ToF) having comorbidities such as low body weight. However, data on clinical outcomes of such approach and tissue response to RVOT stenting in underweight infants are scarce.

Methods: We recruited 16 underweight (<3 kg; average weight, 2. Read More

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http://dx.doi.org/10.1111/jocs.14031DOI Listing
March 2019
1 Read

Patient with CHARGE syndrome.

Pan Afr Med J 2018;31:51. Epub 2018 Sep 24.

Pneumo-allergology unit of Rabat Children Hospital, Faculty of Medicine, Mohammed V University Rabat, Morocco.

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http://dx.doi.org/10.11604/pamj.2018.31.51.7029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431410PMC
April 2019
3 Reads

Results for tricuspid valve surgery in adults with congenital heart disease other than Ebstein's anomaly†.

Eur J Cardiothorac Surg 2019 Mar 28. Epub 2019 Mar 28.

Department of Congenital Cardiac Surgery, IRCCS Policlinico San Donato, San Donato Milanese, Italy.

Objectives: Tricuspid valve (TV) surgery in the adult with congenital heart disease (ACHD) is a frequently performed procedure. The aim of this study was to analyse postoperative and medium-term outcomes.

Methods: We conducted a single-centre retrospective study of patients with ACHD who underwent TV surgery (January 2000-December 2016); patients with Ebstein's anomalies were excluded. Read More

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http://dx.doi.org/10.1093/ejcts/ezz093DOI Listing
March 2019
2 Reads

Right-sided endocarditis from in a patient with tetralogy of Fallot.

Infect Dis Rep 2019 02 26;11(1):7872. Epub 2019 Feb 26.

Division of Pediatric Infectious Diseases.

Infective endocarditis is often caused by bacterial pathogens and can affect native and prosthetic tissue. Common pathogens in pediatric patients include , viridans group streptococci, enterococcal species and coagulase-negative staphylococci, though culture-negative cases are not uncommon. Coagulase-negative staphylococci present a conundrum to clinicians due to the potential of culture contamination. Read More

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http://dx.doi.org/10.4081/idr.2019.7872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397990PMC
February 2019
1 Read

Histopathological evidence of aortopathy in newborns and infants with Tetralogy of Fallot at the time of the surgical repair.

Cardiovasc Pathol 2019 Feb 28;40:59-64. Epub 2019 Feb 28.

Children's Heart Centre, 2nd Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, Prague 5, 150 06, Czech Republic.

Objectives: The purpose of this study was to evaluate the microscopic structural abnormalities of the ascending aorta in infants with Tetralogy of Fallot (ToF) and compare them with aortic samples from control group of small children that died of other diseases. We aimed at identification of the specific histopathological changes associated with ToF and correlation of the severity of these changes with time to surgery and mean levels of saturation in the ToF group, and age at death in control group.

Methods: The full-thickness ascending aortic wall sample was taken from 23 children with ToF at the time of surgical reconstruction (age spread 2 to 19 months) and evaluated by light microscopy. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.02.004DOI Listing
February 2019
1 Read

Commentary: Valve-sparing approach to the hypoplastic pulmonary valve in tetralogy of Fallot repair.

J Thorac Cardiovasc Surg 2019 Feb 19. Epub 2019 Feb 19.

Section of Pediatric Cardiovascular Surgery, Department of Cardiac Surgery, University of Michigan, Ann Arbor, Mich. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2019.02.033DOI Listing
February 2019
1 Read

Surgical outcome in aortopulmonary window beyond the neonatal period.

J Card Surg 2019 Mar 21. Epub 2019 Mar 21.

Department of Cardiothoracic and Vascular Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Objective: Aortopulmonary window (APW) is a rare congenital cardiac defect accounting for 0.1% to 0.2% of all congenital cardiac defects. Read More

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http://dx.doi.org/10.1111/jocs.14023DOI Listing
March 2019
1 Read

Evaluation of pulmonary regurgitation by using different cardiac magnetic resonance indices in children with repaired tetralogy of Fallot.

Chin Med J (Engl) 2019 Apr;132(7):877-879

Cardiac Center, Children's Hospital of Fudan University, Shanghai 201102, China.

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http://dx.doi.org/10.1097/CM9.0000000000000154DOI Listing
April 2019
1 Read

Landmark procedure in paediatric cardiology: 65th anniversary of the first successful repair of tetralogy of Fallot.

Arch Dis Child 2019 Mar 20. Epub 2019 Mar 20.

Department of Pediatric Cardiology, Regional Specialist Hospital, Research and Development Center, Wroclaw, Poland.

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http://dx.doi.org/10.1136/archdischild-2018-316441DOI Listing
March 2019
1 Read

Successful catheter ablation of a ventricular tachycardia by a radiofrequency application from the right atrium in a patient with a tetralogy of Fallot.

Authors:
Takumi Yamada

J Cardiovasc Electrophysiol 2019 Mar 18. Epub 2019 Mar 18.

Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.

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http://dx.doi.org/10.1111/jce.13918DOI Listing
March 2019
1 Read

Repair of Tetralogy of Fallot - Progress or Just a Moving Target?

Authors:
Sitaram M Emani

Semin Thorac Cardiovasc Surg 2019 Mar 13. Epub 2019 Mar 13.

Boston Children's Hospital, 300 Longwood Ave., Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.semtcvs.2019.03.003DOI Listing
March 2019
1 Read

Severe right ventricular dilatation after repair of Tetralogy of Fallot is associated with increased left ventricular preload and stroke volume.

Eur Heart J Cardiovasc Imaging 2019 Mar 14. Epub 2019 Mar 14.

The Heart Centre for Children, The Children's Hospital at Westmead, Corner of Hawkesbury Road and Hainsworth Street, Westmead, New South Wales 2145, Australia.

Aims: Pulmonary regurgitation (PR) and right ventricular (RV) dilatation are common in repaired tetralogy of Fallot (rTOF). Left ventricular (LV) dysfunction is an important risk factor in rTOF. The effect of PR/RV dilatation on LV performance and RV-LV interactions in rTOF are incompletely understood. Read More

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http://dx.doi.org/10.1093/ehjci/jez035DOI Listing
March 2019
1 Read

Thoracic Aortic Dissection in Tetralogy of Fallot: A Review of the National Inpatient Sample Database.

J Am Heart Assoc 2019 Mar;8(6):e011943

1 Department of Cardiovascular Medicine Mayo Clinic Rochester MN.

Background Thoracic aortic aneurysm is common in patients with tetralogy of Fallot ( TOF ); the incidence of thoracic aortic dissection ( TAD ) is unknown, but generally considered to be uncommon. The purpose of this study was to determine incidence and risk factors for TAD in TOF patients. Methods and Results This work is a retrospective review of the National Inpatient Sample ( NIS ) database for cases of ascending TAD among all hospital admissions in adults with TOF , 2000-2014. Read More

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http://dx.doi.org/10.1161/JAHA.119.011943DOI Listing
March 2019
2 Reads
2.882 Impact Factor

Pulmonary Insufficiency: Advantage of Pulmonary Regurgitation Volume Versus Pulmonary Regurgitation Fraction in a Congenital Heart Disease Mixed Population.

J Thorac Imaging 2019 Mar 11. Epub 2019 Mar 11.

Radiology Unit, IRCCS Policlinico San Donato.

Objective: The objective of this study was to compare the use of pulmonary regurgitation volume (PRV) or indexed PRV (PRVi) with that of pulmonary regurgitation fraction (PRF) in the assessment of patients with pulmonary regurgitation (PR) undergoing cardiac magnetic resonance (CMR) imaging.

Materials And Methods: CMR of 176 patients with PR were retrospectively evaluated. Their right ventricular diastolic (end-diastolic volume index [EDVi]) and systolic (end-systolic volume index) volume indexes, stroke volume, and ejection fraction were obtained from cine CMR sequences, whereas phase-contrast flow sequences were analyzed to obtain PRV, PRVi, and PRF. Read More

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http://dx.doi.org/10.1097/RTI.0000000000000400DOI Listing
March 2019
1 Read

Identification of hub genes in chronically hypoxic myocardium using bioinformatics analysis.

Mol Med Rep 2019 May 1;19(5):3871-3881. Epub 2019 Mar 1.

Department of Cardiovascular Surgery, Xinqiao Hospital, Army Medical University, Chongqing 400037, P.R. China.

Chronic hypoxia can be observed in the heart under physiological or pathophysiological states, including embryonic development or cyanotic congenital heart disease. The aim of the present study was to examine gene expression profiles of chronically hypoxic myocardium and to explore the pathophysiological mechanisms by which the heart adapts to chronic hypoxia. Raw data from the next‑generation sequencing data set GSE36761 were downloaded from the Gene Expression Omnibus database. Read More

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http://dx.doi.org/10.3892/mmr.2019.10001DOI Listing
May 2019
1 Read

Midterm outcomes of right ventricular outflow tract reconstruction using the Freestyle xenograft.

Congenit Heart Dis 2019 Mar 12. Epub 2019 Mar 12.

Department of Cardiothoracic Surgery, Cook Children's Medical Center, Fort Worth, Texas.

Objective: Various options exist for right ventricular outflow tract (RVOT) reconstruction in congenital heart disease. The Freestyle porcine aortic root may be used but its longevity is not well defined.

Design: We performed a retrospective review of all non-Ross RVOT reconstructions using the Freestyle root in our institution. Read More

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http://dx.doi.org/10.1111/chd.12765DOI Listing
March 2019
1 Read

The effects of pulmonary valve replacement on QRS duration in repaired tetralogy of Fallot patients with pulmonary regurgitation.

J Electrocardiol 2019 Feb 27;54:36-39. Epub 2019 Feb 27.

Ahmanson/UCLA Adult Congenital Heart Disease Center, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States of America. Electronic address:

Introduction: Chronic pulmonary regurgitation (PR) following surgical correction in Tetralogy of Fallot (TOF) leads to right ventricular (RV) dysfunction, arrhythmias and sudden cardiac death (SCD). Pulmonary valve replacement (PVR) decreases PR and improves RV function, but data regarding QRS duration reduction remain scarce.

Methods: All adult TOF patients undergoing transcatheter PVR or surgical PVR from 2010 to 2016 were included. Read More

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http://dx.doi.org/10.1016/j.jelectrocard.2019.02.010DOI Listing
February 2019
1 Read

Assessment of right ventricular strain in children with repaired tetralogy of Fallot using speckle tracking imaging.

Chin Med J (Engl) 2019 03;132(6):744-748

Department of Echocardiography, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China.

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http://dx.doi.org/10.1097/CM9.0000000000000126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416019PMC
March 2019
5 Reads
1.016 Impact Factor

Myocardial protection and clinical outcomes in Tetralogy of Fallot patients undergoing intracardiac repair: a randomized study of two cardioplegic techniques.

Perfusion 2019 Mar 8:267659119828890. Epub 2019 Mar 8.

1 Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background:: Myocardial protection in Tetralogy of Fallot patients undergoing intracardiac repair is suboptimal due to hypertrophied right ventricle. Hypertrophied myocardium is more susceptible to poor myocardial preservation because of inadequate capillary density as compared to the myocytes. There is a capillary to myocyte ratio mismatch. Read More

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http://dx.doi.org/10.1177/0267659119828890DOI Listing
March 2019
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Echocardiographic parameters of severe pulmonary regurgitation after surgical repair of tetralogy of Fallot.

Congenit Heart Dis 2019 Mar 7. Epub 2019 Mar 7.

Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands.

Aims: Reliable evaluation of the severity and consequences of pulmonary regurgitation (PR) in patients with repaired tetralogy of Fallot (TOF) is crucial to timely identify the need for pulmonary valve intervention. We aimed to identify the accuracy of echocardiographic parameters to differentiate between moderate and severe PR, using phase contrast cardiac magnetic resonance imaging (CMR) as gold standard.

Methods And Results: In this cross-sectional study, 45 TOF patients with both echocardiographic and CMR measurements of PR were enrolled. Read More

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http://dx.doi.org/10.1111/chd.12762DOI Listing
March 2019
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The role of 3D imaging in the follow-up of patients with repaired tetralogy of Fallot.

Eur Rev Med Pharmacol Sci 2019 Feb;23(4):1698-1709

Department of Cardiology and Cardiac Surgery, Bambino Gesù Children's Hospital, IRCCS Rome, Italy.

Objective: The patients with repaired Tetralogy of Fallot (rToF) are a growing population due to the improvement of surgical management in neonatal age. However, the significant pulmonary regurgitation, consequent to the repair, is the most frequent sequelae and leads to a progressive right ventricle dilation over time. The latter, in turn, is responsible for the possible dysfunction of right and/or left ventricle and an increased risk of dangerous ventricular arrhythmias. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17132DOI Listing
February 2019
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Association of NKX2-5, GATA4, and TBX5 polymorphisms with congenital heart disease in Egyptian children.

Mol Genet Genomic Med 2019 Mar 4:e612. Epub 2019 Mar 4.

Histology Department, Benha Faculty of Medicine, Benha University, Benha, Egypt.

Background: Several genes encoding transcription factors are known to be the primary cause of congenital heart disease. NKX2-5 and GATA4 were the first congenital heart disease-causing genes identified by linkage analysis. This study designed to study the association of five single-nucleotide variants of NKX2-5, GATA4, and TBX5 genes with sporadic nonsyndromic cases of a congenital cardiac septal defect in Egyptian children. Read More

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http://doi.wiley.com/10.1002/mgg3.612
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http://dx.doi.org/10.1002/mgg3.612DOI Listing
March 2019
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Cardiopulmonary Exercise Testing-A Valuable Tool, Not Gatekeeper When Referring Patients With ACHD for Transplant Evaluation.

World J Pediatr Congenit Heart Surg 2019 Mar 4:2150135118825263. Epub 2019 Mar 4.

2 Division of Cardiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

Introduction:: Treatment of patients with adult congenital heart disease (ACHD) with advanced therapies including heart transplant (HT) is often delayed due to paucity of objective prognostic markers for the severity of heart failure (HF). While the utility of Cardiopulmonary Exercise Testing (CPET) in non-ACHD patients has been well-defined as it relates to prognosis, CPET for this purpose in ACHD is still under investigation.

Methods:: We performed a retrospective cohort study of 20 consecutive patients with ACHD who underwent HT between March 2010 and February 2016. Read More

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http://dx.doi.org/10.1177/2150135118825263DOI Listing
March 2019
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A review of the management of pulmonary atresia, ventricular septal defect and major aortopulmonary collateral arteries.

Ann Thorac Surg 2019 Mar 1. Epub 2019 Mar 1.

Department of Cardiac Surgery, the Royal Children's Hospital, 50 Flemington Road, Parkville 3052, Victoria, Australia; Department of Paediatrics, University of Melbourne, Parkville 3010, Victoria, Australia; Murdoch Childrens Research Institute, 50 Flemington Road, Parkville 3052, Victoria, Australia. Electronic address:

Background: The management of pulmonary atresia with ventricular septal defect and major aorto-pulmonary collateral arteries (PA/VSD/MAPCAs) has significantly changed over the past 20 years. Unifocalization and rehabilitation have been described as diametrically opposed strategies. An updated review focused on the management of this complex and rare condition is needed. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.046DOI Listing
March 2019
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Catheterization Performed in the Early Postoperative Period After Congenital Heart Surgery in Children.

Pediatr Cardiol 2019 Apr 4;40(4):827-833. Epub 2019 Mar 4.

Universidad Pontificia Bolivariana, Medellín, Colombia.

The aim of this study was to describe pediatric patients who underwent early postoperative cardiac catheterization after congenital heart surgery, their clinical indications, findings, interventions, and complications in a cardiovascular center. A descriptive retrospective study was performed. All catheterizations performed within 6 weeks after congenital heart surgery between January 2004 and December 2014 were reviewed. Read More

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http://link.springer.com/10.1007/s00246-019-02078-3
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http://dx.doi.org/10.1007/s00246-019-02078-3DOI Listing
April 2019
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Recurrent Congenital Heart Diseases Among Neonates Born to Mothers with Congenital Heart Diseases.

Pediatr Cardiol 2019 Apr 4;40(4):865-870. Epub 2019 Mar 4.

Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan.

The frequency of newborns with congenital heart disease (CHD) is approximately 1% in the general population; however, the recurrence rate of CHD in mothers with CHD differs in ethnicity and reports. We therefore aimed to determine the prevalence of CHD among neonates born to mothers with CHD in our institute in Japan. We reviewed the medical charts of 803 neonates delivered by 529 women with CHD at the National Cerebral and Cardiovascular Center from 1982 to 2016. Read More

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http://dx.doi.org/10.1007/s00246-019-02083-6DOI Listing
April 2019
2 Reads
1.550 Impact Factor

Living With, and Caring for, Congenital Heart Disease in Australia: Insights From the Congenital Heart Alliance of Australia and New Zealand Online Survey.

Heart Lung Circ 2019 Jan 24. Epub 2019 Jan 24.

Faculty of Medicine and Health, University of Sydney, Heart Research Institute, Sydney, NSW, Australia.

Background: There is a paucity of data describing the day-to-day experiences of adult Australians personally living with or caring for a child born with congenital heart disease (CHD). Such data would be of great practical importance to inform health care initiatives to improve outcomes.

Methods: 588 men (38. Read More

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http://dx.doi.org/10.1016/j.hlc.2018.12.009DOI Listing
January 2019
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Implications of atrial volumes in surgical corrected Tetralogy of Fallot on clinical adverse events.

Int J Cardiol 2019 May 11;283:107-111. Epub 2019 Feb 11.

Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy.

Background: While left atrial (LA) size has been shown as a strong predictor of cardiovascular diseases in various studies, the role of right atrial (RA) enlargement, especially in the growing population of patients with congenital heart diseases (CHD) is largely unknown. We sought to evaluate (1) RA and LA volumes in patients with repaired Tetralogy of Fallot (TOF) and assess correlations to (2) functional parameters and (3) clinical adverse events.

Methods: 169 patients with repaired TOF were enrolled following a targeted protocol for Cardiovascular magnetic resonance imaging (CMR), Cardiopulmonary exercise tests (CPET), Echocardiography and Measurement of NT-proBNP. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.02.018DOI Listing
May 2019
1 Read