1,304 results match your criteria Testis Sex Cord Stromal Tumor


Unclassified sex cord/gonadal stromal testis tumor with a "pure" spindle cell component: a case report.

Pathologica 2018 Dec;110(4):302-306

Division of Urology Hospital "San Giacomo", Novi Ligure (AL).

Unclassified sex cord/gonadal stromal tumors (SCSTs) composed predominantly of spindle cells are rare. Very few cases have been documented to date. Here, we report a case of "pure" spindle cell tumor of the left testis in a 83-year old man whose morphological and immunohistochemical findings were consistent with a diagnosis of unclassified SCST and review the literature. Read More

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December 2018
5 Reads

Large-cell calcifying Sertoli cell tumour with macrocalcification in partially resected testis of young adult patient.

Malays J Pathol 2018 Dec;40(3):343-348

University of Niš Faculty of Medicine, Scientific Research Centre for Biomedicine, Serbia, Zoran Đinđic Boulevard 81, 18000 Niš, Serbia.

Introduction: There are less than 100 cases of Large-cell calcifying Sertoli cell tumour (LCCSCT) reported in English literature. Most of them are benign, bilateral and affect paediatric population. Malignant cases occur in older patients. Read More

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December 2018
12 Reads

Primary signet-ring stromal tumour of the testis: case report with literature review.

APMIS 2019 Jan;127(1):45-49

Institute of Pathology, University of Göttingen, Göttingen, Germany.

Primary signet-ring stromal tumour of the testis (PSRSTT) is a very rare type of primary testicular tumour, which is not actually mentioned in the current WHO categorization of tumours of the male genital organs. In this case we report about histologically and immunohistochemically features of this rare tumour. In the present case, PSRTT was found in the orchiectomy preparation of a 69-year-old man with painless swelling of his left testicle. Read More

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http://dx.doi.org/10.1111/apm.12907DOI Listing
January 2019
4 Reads

Leydig cell tumor in an Amur tiger (Panthera tigris altaica).

J Vet Med Sci 2019 Feb 12;81(2):186-189. Epub 2018 Dec 12.

Department of Veterinary Pathology, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan.

A 14-year and 8-month-old intact male Amur tiger presented with an enlarged left testis, measuring 5.7 × 5.5 × 4. Read More

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https://www.jstage.jst.go.jp/article/jvms/advpub/0/advpub_18
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http://dx.doi.org/10.1292/jvms.18-0573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395220PMC
February 2019
14 Reads

A Contemporary Review of Common Adult Non-germ Cell Tumors of the Testis and Paratestis.

Surg Pathol Clin 2018 Dec 17;11(4):739-758. Epub 2018 Oct 17.

Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, L235, Stanford, CA 94305, USA. Electronic address:

This article provides a comprehensive review of non-germ cell tumors of the testis and paratestis in adults, incorporating the latest 2016 World Health Organization updates. Clinical features, gross pathologic findings, key morphologic details, immunohistochemical profiles, and differential diagnoses are covered, with an emphasis on how to resolve commonly encountered, and sometimes difficult, differential diagnoses. Read More

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http://dx.doi.org/10.1016/j.path.2018.07.002DOI Listing
December 2018
2 Reads

Malignant Sertoli cell tumor of the testis masquerading as seminoma with bone metastasis.

Indian J Pathol Microbiol 2018 Oct-Dec;61(4):596-599

Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

Sex cord-stromal tumors of the testes are rare malignancies as compared to germ cell tumors. Pure Sertoli cell tumors are still rare representing <1% of testicular cancers and the malignant forms are too rare. Furthermore, the occurrence of metastasis in such cases is extremely rare with <30 cases reported in literature so far to the best of our knowledge. Read More

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http://www.ijpmonline.org/text.asp?2018/61/4/596/242991
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http://dx.doi.org/10.4103/IJPM.IJPM_492_17DOI Listing
February 2019
20 Reads

Modulation of the transcriptomic profile of the R2C tumor Leydig cell line by the adipose tissue derived hormone leptin.

Reprod Biol 2018 Dec 30;18(4):440-449. Epub 2018 Aug 30.

Biology Department, Université de Moncton, Moncton, New-Brunswick, E1A 3E9 Canada.

Leptin is an important adipose derived hormone being secreted by adipocytes and involved in appetite regulation. Disruption of normal plasma levels of leptin has been associated with the pathogenesis of obesity. It is now well established that obesity is associated to an increased risk of cancer development, including testicular cancers. Read More

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http://dx.doi.org/10.1016/j.repbio.2018.08.003DOI Listing
December 2018
19 Reads
1.524 Impact Factor

Immunohistochemical Pitfalls in Genitourinary Pathology: 2018 Update.

Adv Anat Pathol 2018 Nov;25(6):387-399

Robert J. Tomsich Institute of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH.

Immunohistochemistry may be a very useful adjunct to morphologic diagnosis in many areas of surgical pathology, including genitourinary pathology. In this review, we address common diagnostic dilemmas where immunophenotypic analysis may be utilized and we highlight pitfalls specific to each scenario. For prostate, we review the diagnosis of limited prostatic adenocarcinoma and the distinction of high-grade prostatic adenocarcinoma from urothelial carcinoma. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000205DOI Listing
November 2018
7 Reads

Protein expression of the transcription factors DMRT1, TCLF5, and OCT4 in selected germ cell neoplasms of the testis.

Hum Pathol 2018 Dec 29;82:68-75. Epub 2018 Jul 29.

Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Department of Urology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

In the present study, we investigated protein expression of the transcription factors mammalian doublesex and mab-3 related transcription factor 1 (DMRT1), basic helix-loop-helix transcription factor-like 5 (TCLF5), and octamer-binding transcription factor 4 (OCT4) in normal human spermatogenesis, testicular mixed germ cell-sex cord stromal tumor (MGC-SCST), spermatocytic tumor, and seminoma. In normal human spermatogenesis, DMRT1 is expressed in the nuclei of spermatogonia but not in those of more mature germ cells. By way of contrast, TCLF5 is expressed in the nuclei of some clusters of primary spermatocytes that have entered meiosis 1, in secondary spermatocytes, and in round (early) spermatids in the seminiferous tubules of adults during the reproductive years. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.07.019DOI Listing
December 2018
9 Reads

[Clinicopathologic and molecular characterizations of Sertoli cell tumor, not otherwise specified of the testis].

Zhonghua Bing Li Xue Za Zhi 2018 Jul;47(7):505-510

Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.

To investigate the histomorpholgic spectrum, immunophenotypic, and molecular genetic features of Sertoli cell tumor, not otherwise specified (SCT, NOS) of the testis. Seven cases of SCT, NOS of the testis were analyzed(4 from Peking University Third Hospital and 3 from Zhejiang Provincial People's Hospital) between 2008 and 2017. The histopathologic features were examined based on HE staining, and EnVision method was used for immunohistochemistry staining of calretinin, inhibin, β-catenin, cyclinD1, CD10, CKpan, neuroendocrine markers, WT1, Melan A, vimentin, SALL4, GATA3, PAX8, and S-100 protein. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.07.005DOI Listing
July 2018
30 Reads

Management of testicular Leydig cell tumor: A case report.

Medicine (Baltimore) 2018 Jun;97(25):e11158

Department of Radiology, the Second Affiliated Hospital of Nanjing Medical University.

Rationale: Testicular Leydig cell tumor (LCT) is a rare neoplasm. It commonly presents as a painless testicular mass with or without endocrine changes. Histological and immunohistochemical examination play important roles in differentiating LCT from testicular germ cell tumors. Read More

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http://dx.doi.org/10.1097/MD.0000000000011158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023788PMC
June 2018
13 Reads

Insights into the role of estrogen-related receptors α, β and γ in tumor Leydig cells.

Tissue Cell 2018 Jun 13;52:78-91. Epub 2018 Apr 13.

Department of Endocrinology, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, Gronostajowa 9, 30-387, Krakow, Poland.

In this study, we demonstrate, for the first time, estrogen-related receptor (ERR) regulation of the physiological and biochemical status of testicular tumor Leydig cells. In a mouse tumor Leydig cells, ERRs (α, β, and γ) were silenced via siRNA. Cell morphology and cell physiology (proliferation and observation of monolayer formation) were performed by inverted phase-contrast microscope. Read More

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http://dx.doi.org/10.1016/j.tice.2018.04.003DOI Listing
June 2018
9 Reads

[Fibrothecoma of the testis: A case report in an adult].

Ann Pathol 2018 Aug 24;38(4):249-252. Epub 2018 May 24.

Service de pathologie, centre hospitalier de Marne-La-Vallée, 2-4, cours de la Gondoire, 77600 Jossigny, France.

Fibrothecal tumors belong to sex cord/stromal tumors (SCSTS). They represent 1 to 4.7 % of the organics tumors of ovary (Chechia et al. Read More

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http://dx.doi.org/10.1016/j.annpat.2018.04.001DOI Listing
August 2018
4 Reads

Testis-sparing surgery of unilateral testicular large-cell calcifying Sertoli cell tumor: a sporadic case.

Turk J Urol 2018 Jul;44(4):370-372

Department of Urology, Medeniyet University Göztepe Training and Research Hospital, İstanbul, Turkey.

Testicular sex cord-stromal tumors constitute a small portion of all types of testicular tumors. Only 1% of these tumors are pure Sertoli cell tumors. Sertoli cell tumors have three identified subgroups: large-cell calcifying (LCCSCT), sclerosing Sertoli cell and general type. Read More

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http://dx.doi.org/10.5152/tud.2017.69345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016669PMC
July 2018
14 Reads

A novel mouse model of testicular granulosa cell tumors.

Mol Hum Reprod 2018 07;24(7):343-356

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA.

Study Question: What is the role of dysregulated transforming growth factor beta (TGFB) signaling in the development of sex cord-stromal tumors in the testis?

Summary Answer: Overactivation of TGFB signaling results in the development of testicular tumors resembling granulosa cell tumors (GrCTs).

What Is Known Already: In an earlier study, we demonstrated that constitutively active TGFB receptor 1 (TGFBR1) in ovarian somatic cells promotes the development of ovarian GrCTs. However, the consequence of dysregulation of TGFB signaling in the pathobiology of the testis, remains poorly defined. Read More

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http://dx.doi.org/10.1093/molehr/gay023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279300PMC
July 2018
11 Reads

Prepubertal Malignant Large Cell Calcifying Sertoli Cell Tumor of the Testis.

Urology 2018 Jul 4;117:145-149. Epub 2018 Apr 4.

Department of Pathology, University of Michigan, Ann Arbor, MI. Electronic address:

An otherwise healthy 7-year-old boy was diagnosed with malignant large cell calcifying Sertoli cell tumor (LCCSCT) of the testis. He underwent attempted partial orchiectomy with conversion to radical orchiectomy due to suspected malignancy on intraoperative frozen section. There was no lymph node or visceral metastases. Read More

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http://dx.doi.org/10.1016/j.urology.2018.03.033DOI Listing
July 2018
4 Reads

Mechanism of bisphenol AF-induced progesterone inhibition in human chorionic gonadotrophin-stimulated mouse Leydig tumor cell line (mLTC-1) cells.

Environ Toxicol 2018 Jun 25;33(6):670-678. Epub 2018 Mar 25.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.

Bisphenol AF (BPAF) has been shown to inhibit testicular steroidogenesis in male rats. However, the precise mechanisms related to the toxic effects of BPAF on reproduction remain poorly understood. In the present study, a mouse Leydig tumor cell line (mLTC-1) was used as a model to investigate the mechanism of steroidogenic inhibition and to identify the molecular target of BPAF. Read More

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http://dx.doi.org/10.1002/tox.22554DOI Listing
June 2018
6 Reads

Spectrum of findings in orchiectomy specimens of persons undergoing gender confirmation surgery.

Hum Pathol 2018 06 17;76:91-99. Epub 2018 Mar 17.

Department of Pathology and Laboratory Medicine, Rhode Island Hospital, Providence, RI 02903, USA.

Gender confirmation surgery is increasingly common in persons with gender dysphoria. We describe changes seen in gonads from individuals seeking male-to-female physical adaptation. We studied 99 orchiectomies from 50 persons. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.03.007DOI Listing
June 2018
11 Reads
2.770 Impact Factor

Testis Sparing Surgery for Benign Testicular Masses: Diagnostics and Therapeutic Approaches.

J Urol 2018 08 9;200(2):353-360. Epub 2018 Mar 9.

Department of Urology, University Hospital Cologne, Cologne, Germany; Department of Medicine III, University Hospital RWTH Aachen (SHL), Aachen, Germany. Electronic address:

Purpose: Small benign testicular masses are often misinterpreted as germ cell tumors and immediate inguinal orchiectomy is performed. We analyzed the diagnostic and therapeutic workup of testicular masses to improve preoperative stratification algorithms.

Materials And Methods: We performed a retrospective, single center analysis of the records of 522 patients diagnosed with primary testicular masses of unknown malignant potential. Read More

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http://dx.doi.org/10.1016/j.juro.2018.03.007DOI Listing
August 2018
8 Reads

[Effects of monobutyl phthalate on migration and invasion of mouse Leydig tumor cells].

Zhonghua Yu Fang Yi Xue Za Zhi 2018 Feb;52(2):175-179

Department of Safety Assessment and Research Center for Drug, Pesticide and Veterinary Drug of Jiangsu Province, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China.

This study aimed to investigate the influence of monobutyl phthalate (MBP) on the expressions of epithelial-mesenchymal transition (EMT)-related proteins, migration and invasion of mouse Leydig tumor cells (MLTC-1) cells. After exposed to different doses of MBP (0、10(-7)、10(-6), 10(-5), 10(-4), 10(-3) mol/L) for 24 h or 48 h, cell viability was determined by 3-(4 5-dimethyl-2-thiazolyl)-2 5-diphenyl-2-H-tetrazolium bromide (MTT) assay. Expressions of vimentin, E-cadherin, N-cadherin and Snail proteins related to EMT were detected by Western blot. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2018.02.011DOI Listing
February 2018
4 Reads

CRISPR/Cas9‒Mediated Tspo Gene Mutations Lead to Reduced Mitochondrial Membrane Potential and Steroid Formation in MA-10 Mouse Tumor Leydig Cells.

Endocrinology 2018 02;159(2):1130-1146

Research Institute of the McGill University Health Centre and Department of Medicine, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.

The outer mitochondrial membrane translocator protein (TSPO) binds cholesterol with high affinity and is involved in mediating its delivery into mitochondria, the rate-limiting step in hormone-induced steroidogenesis. Specific ligand binding to TSPO has been shown to initiate steroid formation. However, recent studies of the genetic deletion of Tspo have provided conflicting results. Read More

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http://dx.doi.org/10.1210/en.2017-03065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793793PMC
February 2018
13 Reads

The Morphologic Spectrum of Sertoliform Cystadenoma of the Rete Testis: A Series of 15 Cases.

Am J Surg Pathol 2018 02;42(2):141-149

Department of Pathology, Johns Hopkins Medical Institute, Baltimore, MD.

Sertoliform cystadenoma of the rete testis (SCRT) is rare with only 9 cases reported to date in the literature, none with follow-up. Four large genitourinary pathology consult services were searched. We identified 15 cases of SCRT. Read More

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http://dx.doi.org/10.1097/PAS.0000000000000997DOI Listing
February 2018
9 Reads

Testicle-sparing surgery versus radical orchiectomy in the management of Leydig cell tumors: results from a multicenter study.

World J Urol 2018 Mar 11;36(3):427-433. Epub 2017 Dec 11.

Department of Urology and Renal Transplantation, University Hospital of Besancon, 3 Boulevard Fleming, 25000, Besancon, France.

Objective: To compare the oncological outcomes of testicle-sparing surgery (TSS) and radical orchiectomy (RO) in patients with Leydig cell tumor (LCT) of the testis.

Patients And Methods: A multicenter retrospective clinical study was conducted in 12 centers in France. All the patients with histologically proven LCT were included and analyzed according to treatment (organ-sparing surgery or radical orchiectomy). Read More

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http://dx.doi.org/10.1007/s00345-017-2151-0DOI Listing
March 2018
26 Reads

Microcystic Stromal Tumor of Testicle: First Case Report and Literature Review.

Cancer Res Treat 2018 Oct 24;50(4):1452-1457. Epub 2017 Nov 24.

Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Microcystic stromal tumor (MCST) is a rare subtype of sex cord-stromal neoplasm. Tumors from all 31 previously reported cases were located in the ovary. Herein, we present a unique case of a right-side testicular tumor in a 33-year-old Chinese male. Read More

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http://dx.doi.org/10.4143/crt.2017.414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192906PMC
October 2018
7 Reads

An Uncommon Presentation of a Metachronous Testicular Primary Nonseminoma and Seminoma Separated by Two Decades and a Testicular Cancer Literature Review.

Case Rep Oncol 2017 Sep-Dec;10(3):832-839. Epub 2017 Sep 15.

Cancer Treatment Centers of America, Southwestern Regional Center, Tulsa, OK, USA.

Introduction: Testicular cancer is the most common malignancy in men aged 15-40 years [Bols et al.: Philadelphia, Wolters Kluwer, Lippincott Williams & Wilkins, 2011]. Its incidence comprises 0. Read More

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http://dx.doi.org/10.1159/000478846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649222PMC
September 2017
22 Reads

Germ Cell Neoplasia in Situ and Preserved Fertility Despite Suppressed Gonadotropins in a Patient With Testotoxicosis.

J Clin Endocrinol Metab 2017 12;102(12):4411-4416

Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Denmark.

Context: Testotoxicosis is an autosomal-dominant, male-limited disorder. Activating mutations in the luteinizing hormone receptor gene (LHCGR) cause high autonomous testosterone secretion, resulting in early-onset peripheral precocious puberty. Little is known about long-term consequences of testotoxicosis. Read More

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http://dx.doi.org/10.1210/jc.2017-01761DOI Listing
December 2017
25 Reads

Dynamic contrast-enhanced and diffusion-weighted MR imaging in the characterisation of small, non-palpable solid testicular tumours.

Eur Radiol 2018 Feb 30;28(2):554-564. Epub 2017 Aug 30.

Testis-Unit (TU), Policlinico Umberto I, Rome, Italy.

Objectives: To explore the role of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), using semiquantitative and quantitative parameters, and diffusion-weighted (DW) MRI in differentiating benign from malignant small, non-palpable solid testicular tumours.

Methods: We calculated the following DCE-MRI parameters of 47 small, non-palpable solid testicular tumours: peak enhancement (PE), time to peak (TTP), percentage of peak enhancement (Epeak), wash-in-rate (WIR), signal enhancement ratio (SER), volume transfer constant (K), rate constant (K), extravascular extracellular space volume fraction (V) and initial area under the curve (AUC). DWI signal intensity and apparent diffusion coefficient (ADC) values were evaluated. Read More

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http://dx.doi.org/10.1007/s00330-017-5013-7DOI Listing
February 2018
24 Reads

Giant mixed Sertoli-Leydig-Granulosa sex cord tumor of the testis; clinical, histopathological, and radiological features: a case report.

Pan Afr Med J 2017 19;27:51. Epub 2017 May 19.

College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.

Sex cord tumors of the testis in post pubertal men are rare. Mixed leydig-Sertoli-Granulosa sex cord tumors are exceptionally rare. To the best of our knowledge there are only three reported similar cases in the literature. Read More

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http://dx.doi.org/10.11604/pamj.2017.27.51.10571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554693PMC
September 2017
7 Reads

Primary signet ring stromal tumor of the testis: a study of 13 cases indicating their phenotypic and genotypic analogy to pancreatic solid pseudopapillary neoplasm.

Hum Pathol 2017 09 21;67:85-93. Epub 2017 Jul 21.

Department of Pathology, Faculty of Medicine in Plzen, 30460, Charles University in Prague, 11636, Biopticka laborator s.r.o., Plzen, 30100, Czech Republic.

Primary signet ring stromal tumor of the testis (PSRSTT) is an extremely rare tumor described only twice in the literature. Pancreatic-analogue solid pseudopapillary neoplasm (SPN) of the testis is a recently reported entity with morphological overlap with PSRSTT. We reviewed our files to find all cases of PSRSTT to better characterize this entity. Read More

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http://dx.doi.org/10.1016/j.humpath.2017.07.010DOI Listing
September 2017
57 Reads

The natural history of Leydig cell testicular tumours: an analysis of the National Cancer Registry.

Ir J Med Sci 2018 May 19;187(2):323-326. Epub 2017 Jul 19.

Department of Urology, Mercy University Hospital, Cork, Ireland.

Background: Leydig cell tumour (LCT) of the testis is a rare histological subtype of stromal tumours, accounting for 1 to 3% of testicular neoplasms. The natural history of LCT is poorly understood.

Aims: The aim of this study was to assess the incidence and natural history of Leydig cell tumours (LCT) of the testes. Read More

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http://dx.doi.org/10.1007/s11845-017-1662-4DOI Listing
May 2018
10 Reads

Leydig Cell Tumor of Testis in a Child: An Uncommon Presentation.

J Indian Assoc Pediatr Surg 2017 Jul-Sep;22(3):181-183

Department of Pediatric Surgery, IPGME and R, Kolkata, India.

Leydig cell tumors (LCTs) are rare testicular tumors. Incidence is 1%-3% of all testicular neoplasms, bilateral in 10%. They are frequently hormonally active, leading to feminizing or virilizing syndromes. Read More

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http://dx.doi.org/10.4103/jiaps.JIAPS_4_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473310PMC
July 2017
9 Reads

[Adult type granulosa cell testicular tumor. Case report and bibliographic review.]

Arch Esp Urol 2017 Jul;70(6):617-620

Servicio de Urología.Hospital Universitario de Getafe. Madrid. España.

Objetive: To describe the adult type granulosa cell testicular tumors (classified as sex cordstromal tumor) due to their behavior, hardly known with a small number of cases reported.

Method: We report a new case of a 59-year-old man presenting an adult type granulosa cell tumor of the testis (AGCTT), painless, with a 3.3 centimeter intratesticular heterogeneous mass on ultrasound, with solid and cystic areas. Read More

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July 2017
11 Reads

Expression patterns of HENMT1 and PIWIL1 in human testis: implications for transposon expression.

Reproduction 2017 10 4;154(4):363-374. Epub 2017 Jul 4.

Institute for Veterinary AnatomyHistology and Embryology, Justus Liebig University, Giessen, Germany.

This study aimed to define the expression patterns of HENMT1 and PIWI proteins in human testis and investigate their association with transposon expression, infertility sub-type or development of testicular germ cell tumours (TGCTs). Testis biopsies showing normal spermatogenesis were used to identify normal localisation patterns of HENMT1 and PIWIL1 by immunolocalisation and RT-PCR after laser microdissection. 222 testis biopsies representing normal spermatogenesis, hypospermatogenesis, spermatogenic arrests, Sertoli cell-only (SCO) tumours and TGCTs were analysed by RT-qPCR for expression of and Additionally, -overexpressing TCam2 seminoma cell lines were analysed for the same parameters by RT-qPCR. Read More

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http://dx.doi.org/10.1530/REP-16-0586DOI Listing
October 2017
12 Reads

Adult-type granulosa cell tumor of the testis: report of a case and review of literature.

Pan Afr Med J 2017 4;26:198. Epub 2017 Apr 4.

Mohamed VI Center of Cancer Treatment, Morocco.

Granulosa cell tumors is classified into juvenile and adult types and comprise less than 5% of ovarian tumors in women and are much rarer in men which only 45 have been previously reported. We report here a 40-year young man with a left testicular adult type granulosa cell tumor. The tumor measured 5. Read More

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http://dx.doi.org/10.11604/pamj.2017.26.198.11523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483374PMC
July 2017
16 Reads

Poorly Differentiated Sertoli-Leydig Cell Tumour of Ovary with Heterologous Elements.

J Clin Diagn Res 2017 May 1;11(5):XD01-XD02. Epub 2017 May 1.

Assistant Professor, Department of Pathology, Acharya Harihara Regional Cancer Centre, Cuttack, Odisha, India.

Sertoli-Leydig Cell Tumour (SLCT) is included under sex-cord stromal tumour of testis or ovary. Ovarian pathology is an extremely rare entity constituting less than 0.5% of all ovarian neoplasms. Read More

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http://dx.doi.org/10.7860/JCDR/2017/25262.9860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483794PMC
May 2017
12 Reads

Nonpalpable Intratesticular Mass in a Young Man With a History of Contralateral Retractile Testis.

Oncology (Williston Park) 2017 06;31(6):484, 489-91

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June 2017
1 Read

Testicular Seminoma and Its Mimics: From the Radiologic Pathology Archives.

Radiographics 2017 Jul-Aug;37(4):1085-1098. Epub 2017 Jun 2.

From the Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Md (J.M.); American Institute for Radiologic Pathology, 1100 Wayne Ave, Suite 1020, Silver Spring, MD 20910 (J.M., D.J.W.); Department of Radiology, Johns Hopkins School of Medicine, Washington, DC (D.J.W., A.L.A.); and Joint Pathology Center, Silver Spring, Md (I.A.S.).

Testicular seminoma is the most common malignant tumor of the testis. It classically manifests as a painless mass. Radiologic evaluation with high-frequency ultrasonography (US) is critical for diagnosis. Read More

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http://dx.doi.org/10.1148/rg.2017160164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548453PMC
November 2017
29 Reads

Naloxegol, an opioid antagonist with reduced CNS penetration: Mode-of-action and human relevance for rat testicular tumours.

Toxicol Appl Pharmacol 2017 08 26;329:85-95. Epub 2017 May 26.

Department of Regulatory Safety, Drug Safety & Metabolism, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom; AstraZenweca, Department of Non-Clinical Drug Safety, Mundipharma Research Ltd., Cambridge, United Kingdom.

Naloxegol is an opioid antagonist which has been developed for the treatment of patients with opioid induced constipation. In the nonclinical safety program naloxegol was shown to have a very benign toxicity profile. In the rat, but not the mouse, 2-year carcinogenicity study a change in tumour pattern with an increase in testicular Leydig cell tumours (LCT) was observed after dosing at high (supra-pharmacological) concentrations. Read More

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http://dx.doi.org/10.1016/j.taap.2017.05.032DOI Listing
August 2017
36 Reads

Benign Large-cell Calcifying Sertoli Tumor of the Testis in a 13-Year-Old Male Patient Treated With Partial Orchiectomy.

Urology 2017 Sep 24;107:226-228. Epub 2017 May 24.

Department of Pediatric Urology, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA.

Large-cell calcifying Sertoli cell tumor (LCCSCT) of the testis is an exceptionally rare lesion, found sparsely in any medical literature. There is a correlation between this entity and Peutz-Jeghers syndrome and Carney complex (40% of tumors). The remaining 60% of tumors are sporadic. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00904295173051
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http://dx.doi.org/10.1016/j.urology.2017.05.023DOI Listing
September 2017
32 Reads

Testicular tumors of adrenogenital syndrome: From physiopathology to therapy.

Presse Med 2017 Jun 23;46(6 Pt 1):572-578. Epub 2017 May 23.

Ibn El Jazzar teaching hospital, Les Aghlabides surgical division, urology department, 3100 Kairouan, Tunisia.

Testicular tumor of adrenogenital syndrome is a rare and benign anomaly usually presenting as bilateral testicular masses. It is the most important cause of infertility in adult male congenital adrenal hyperplasia. Distinction between testicular tumors of adrenogenital syndrome and Leydig cell tumors can be problematic; it is based on clinical, histopathologic, immunohistochemical and endocrine features. Read More

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http://dx.doi.org/10.1016/j.lpm.2017.05.006DOI Listing
June 2017
36 Reads

[Germ cell and sex cord-stromal tumors of the testis : WHO classification 2016].

Authors:
G Mikuz

Pathologe 2017 May;38(3):209-220

Institut für Pathologie, Universität Innsbruck, Müllerstraße 44, 6020, Innsbruck, Österreich.

Earlier revisions of the WHO classification of testicular tumors, which was originally published in 1977, contained only minor additions. In the WHO 2016 classification, in contrast, germ cell tumors are split into two major groups based on their distinct pathohistogenesis, i. e. Read More

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http://dx.doi.org/10.1007/s00292-017-0290-0DOI Listing
May 2017
30 Reads

Perspectives on testicular sex cord-stromal tumors and those composed of both germ cells and sex cord-stromal derivatives with a comparison to corresponding ovarian neoplasms.

Hum Pathol 2017 07 23;65:1-14. Epub 2017 Apr 23.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202; Department of Urology, Indiana University School of Medicine, Indianapolis, IN 46202. Electronic address:

Sex cord-stromal tumors (SCSTs) are the second most frequent category of testicular neoplasms, accounting for approximately 2% to 5% of cases. Both genetic and epigenetic factors account for the differences in frequency and histologic composition between testicular and ovarian SCSTs. For example, large cell calcifying Sertoli cell tumor and intratubular large cell hyalinizing Sertoli cell neoplasia occur in the testis but have not been described in the ovary. Read More

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http://dx.doi.org/10.1016/j.humpath.2017.04.009DOI Listing
July 2017
18 Reads

Mammary gland tumors in a male Cocker Spaniel.

Acta Vet Scand 2017 Apr 11;59(1):20. Epub 2017 Apr 11.

Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon, 200-701, Republic of Korea.

Background: Mammary gland tumors are the most common tumors in sexually intact female dogs; however, they are rare in male dogs. This study was conducted to investigate the relationship between sexual hormones and mammary gland tumors in a male dog.

Case Presentation: A 13-year-old, intact male Cocker Spaniel presented to the Veterinary Teaching Hospital of Kangwon National University, Republic of Korea, with an acute right ruptured caudal abdominal mass. Read More

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http://dx.doi.org/10.1186/s13028-017-0290-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387325PMC
April 2017
23 Reads

[Pathologic changes of spontaneous tumors in Sprague-Dawley and Wistar rats].

Zhonghua Bing Li Xue Za Zhi 2017 Apr;46(4):249-254

JOINN Laboratories, Beijing 100176, China.

To investigate the spontaneous neoplastic lesions and their incidences in Sprague-Dawley (SD) and Wistar rats, and to accumulate background data for carcinogenicity studies. One hundred and eighty SD rats and 240 Wistar rats (4-week old) , half in each sex, were used in this study. The rats were housed routinely under specific pathogen-free environment and euthanized after 104 weeks. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2017.04.007DOI Listing
April 2017
5 Reads

An adolescent with large cell calcifying sertoli cell tumor of the testis and undiagnosed Carney Complex: A case report.

Diagn Cytopathol 2017 Jul 9;45(7):634-639. Epub 2017 Mar 9.

Department of Pathology, University of Alabama, Birmingham, Alabama, 35294.

Carney Complex (CNC) is a rare autosomal dominant condition with characteristic clinical presentation, tumor development, and unique genetic mutation. We present a unique case and literature review of CNC in which two neoplasms characteristic of this complex were initially diagnosed through cytological fine needle aspirate specimens, leading to the identification of CNC, with subsequent surgical and cytogenetic confirmation. Diagn. Read More

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http://dx.doi.org/10.1002/dc.23700DOI Listing
July 2017
20 Reads

Leydig cell hyperplasia in children: Case series and review.

J Pediatr Urol 2017 Apr 10;13(2):158-163. Epub 2017 Feb 10.

Department of Paediatric Surgery, Monash Children's Hospital, Melbourne, Australia.

Introduction: Leydig cell hyperplasia (LCH) and Leydig cell tumours (LCTs) in children are rare, typically presenting with precocious puberty. Previously, orchidectomy was the routine management; however, more recently, testis-sparing surgery has been performed with good results. We present a series of unusual presentations of LCH, raising new management questions, and a review of the literature regarding LCH and LCT in children. Read More

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http://dx.doi.org/10.1016/j.jpurol.2016.12.028DOI Listing
April 2017
23 Reads

The role of beta-catenin mutation and SOX9 expression in sex cord-stromal tumours of the testis.

Virchows Arch 2017 Apr 16;470(4):421-428. Epub 2017 Feb 16.

Gemeinschaftspraxis Pathologie, Am Fuchsengraben 3, 82319, Starnberg, Germany.

The WHO classification of testis tumours includes the group of sex cord-stromal tumours. They are divided into several histological types, i.e. Read More

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http://dx.doi.org/10.1007/s00428-017-2090-6DOI Listing
April 2017
24 Reads

Atypical Leydig Cell Tumor in Children: Report of 2 Cases.

Pediatrics 2016 11;138(5)

Departments of Pediatrics, and.

Leydig cell tumors (LCTs) are rare cord-stromal tumors that may occur in testis or ovaries and may produce androgens or estrogens. The majority has been found in men between the ages of 20 and 60 years. Adults with androgen-secreting LCTs are usually asymptomatic; feminizing syndromes may result from the production of estradiol or the peripheral aromatization of testosterone. Read More

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http://dx.doi.org/10.1542/peds.2016-0151DOI Listing
November 2016
22 Reads

Comparative immunomorphology of testicular Sertoli and sertoliform tumors.

Hum Pathol 2017 03 8;61:181-189. Epub 2016 Dec 8.

Departments of Pathology and Laboratory Medicine, Veterans Administration Health Care Service, Minneapolis, MN 55417; Departments of Pathology and Laboratory Medicine, University of Minnesota School of Medicine, Minneapolis, MN 55455.

Sertoli cell (SC) and sertoliform tumors of the testis are very uncommon; for this reason their differential diagnosis and classification can be challenging. We applied an extensive immunophenotypic panel that included androgenic hormones, enzymes and receptors, neuroendocrine, lineage and genitourinary markers to a series of these lesions to determine if and which immunostains can aid in their diagnostic workup. Study cases included: 2 androgen insensitivity syndrome-associated SC adenomas, 3 SC tumors (SCT) not otherwise specified (SCT-NOS), 3 sclerosing SCT, 2 large cell calcifying SCT, 1 SCT with heterologous sarcomatous elements, 1 malignant SCT, and 1 sertoliform rete testis adenoma (sertoliform RTA). Read More

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http://dx.doi.org/10.1016/j.humpath.2016.11.004DOI Listing
March 2017
21 Reads