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APMIS 2019 Jan;127(1):45-49

Institute of Pathology, University of Göttingen, Göttingen, Germany.

Primary signet-ring stromal tumour of the testis (PSRSTT) is a very rare type of primary testicular tumour, which is not actually mentioned in the current WHO categorization of tumours of the male genital organs. In this case we report about histologically and immunohistochemically features of this rare tumour. In the present case, PSRTT was found in the orchiectomy preparation of a 69-year-old man with painless swelling of his left testicle. Read More

Surg Pathol Clin 2018 Dec 17;11(4):739-758. Epub 2018 Oct 17.

Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, L235, Stanford, CA 94305, USA. Electronic address:

This article provides a comprehensive review of non-germ cell tumors of the testis and paratestis in adults, incorporating the latest 2016 World Health Organization updates. Clinical features, gross pathologic findings, key morphologic details, immunohistochemical profiles, and differential diagnoses are covered, with an emphasis on how to resolve commonly encountered, and sometimes difficult, differential diagnoses. Read More

Indian J Pathol Microbiol 2018 Oct-Dec;61(4):596-599

Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

Sex cord-stromal tumors of the testes are rare malignancies as compared to germ cell tumors. Pure Sertoli cell tumors are still rare representing <1% of testicular cancers and the malignant forms are too rare. Furthermore, the occurrence of metastasis in such cases is extremely rare with <30 cases reported in literature so far to the best of our knowledge. Read More

Reprod Biol 2018 Dec 30;18(4):440-449. Epub 2018 Aug 30.

Biology Department, Université de Moncton, Moncton, New-Brunswick, E1A 3E9 Canada.

Leptin is an important adipose derived hormone being secreted by adipocytes and involved in appetite regulation. Disruption of normal plasma levels of leptin has been associated with the pathogenesis of obesity. It is now well established that obesity is associated to an increased risk of cancer development, including testicular cancers. Read More

Adv Anat Pathol 2018 Nov;25(6):387-399

Robert J. Tomsich Institute of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH.

Immunohistochemistry may be a very useful adjunct to morphologic diagnosis in many areas of surgical pathology, including genitourinary pathology. In this review, we address common diagnostic dilemmas where immunophenotypic analysis may be utilized and we highlight pitfalls specific to each scenario. For prostate, we review the diagnosis of limited prostatic adenocarcinoma and the distinction of high-grade prostatic adenocarcinoma from urothelial carcinoma. Read More

Hum Pathol 2018 Dec 29;82:68-75. Epub 2018 Jul 29.

Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Department of Urology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

In the present study, we investigated protein expression of the transcription factors mammalian doublesex and mab-3 related transcription factor 1 (DMRT1), basic helix-loop-helix transcription factor-like 5 (TCLF5), and octamer-binding transcription factor 4 (OCT4) in normal human spermatogenesis, testicular mixed germ cell-sex cord stromal tumor (MGC-SCST), spermatocytic tumor, and seminoma. In normal human spermatogenesis, DMRT1 is expressed in the nuclei of spermatogonia but not in those of more mature germ cells. By way of contrast, TCLF5 is expressed in the nuclei of some clusters of primary spermatocytes that have entered meiosis 1, in secondary spermatocytes, and in round (early) spermatids in the seminiferous tubules of adults during the reproductive years. Read More

Zhonghua Bing Li Xue Za Zhi 2018 Jul;47(7):505-510

Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.

To investigate the histomorpholgic spectrum, immunophenotypic, and molecular genetic features of Sertoli cell tumor, not otherwise specified (SCT, NOS) of the testis. Seven cases of SCT, NOS of the testis were analyzed(4 from Peking University Third Hospital and 3 from Zhejiang Provincial People's Hospital) between 2008 and 2017. The histopathologic features were examined based on HE staining, and EnVision method was used for immunohistochemistry staining of calretinin, inhibin, β-catenin, cyclinD1, CD10, CKpan, neuroendocrine markers, WT1, Melan A, vimentin, SALL4, GATA3, PAX8, and S-100 protein. Read More

Medicine (Baltimore) 2018 Jun;97(25):e11158

Department of Radiology, the Second Affiliated Hospital of Nanjing Medical University.

Rationale: Testicular Leydig cell tumor (LCT) is a rare neoplasm. It commonly presents as a painless testicular mass with or without endocrine changes. Histological and immunohistochemical examination play important roles in differentiating LCT from testicular germ cell tumors. Read More

Tissue Cell 2018 Jun 13;52:78-91. Epub 2018 Apr 13.

Department of Endocrinology, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, Gronostajowa 9, 30-387, Krakow, Poland.

In this study, we demonstrate, for the first time, estrogen-related receptor (ERR) regulation of the physiological and biochemical status of testicular tumor Leydig cells. In a mouse tumor Leydig cells, ERRs (α, β, and γ) were silenced via siRNA. Cell morphology and cell physiology (proliferation and observation of monolayer formation) were performed by inverted phase-contrast microscope. Read More

Turk J Urol 2018 Jul;44(4):370-372

Department of Urology, Medeniyet University Göztepe Training and Research Hospital, İstanbul, Turkey.

Testicular sex cord-stromal tumors constitute a small portion of all types of testicular tumors. Only 1% of these tumors are pure Sertoli cell tumors. Sertoli cell tumors have three identified subgroups: large-cell calcifying (LCCSCT), sclerosing Sertoli cell and general type. Read More

Mol Hum Reprod 2018 Jul;24(7):343-356

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA.

Study Question: What is the role of dysregulated transforming growth factor beta (TGFB) signaling in the development of sex cord-stromal tumors in the testis?

Summary Answer: Overactivation of TGFB signaling results in the development of testicular tumors resembling granulosa cell tumors (GrCTs).

What Is Known Already: In an earlier study, we demonstrated that constitutively active TGFB receptor 1 (TGFBR1) in ovarian somatic cells promotes the development of ovarian GrCTs. However, the consequence of dysregulation of TGFB signaling in the pathobiology of the testis, remains poorly defined. Read More

Urology 2018 Jul 4;117:145-149. Epub 2018 Apr 4.

Department of Pathology, University of Michigan, Ann Arbor, MI. Electronic address:

An otherwise healthy 7-year-old boy was diagnosed with malignant large cell calcifying Sertoli cell tumor (LCCSCT) of the testis. He underwent attempted partial orchiectomy with conversion to radical orchiectomy due to suspected malignancy on intraoperative frozen section. There was no lymph node or visceral metastases. Read More

Environ Toxicol 2018 Jun 25;33(6):670-678. Epub 2018 Mar 25.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.

Bisphenol AF (BPAF) has been shown to inhibit testicular steroidogenesis in male rats. However, the precise mechanisms related to the toxic effects of BPAF on reproduction remain poorly understood. In the present study, a mouse Leydig tumor cell line (mLTC-1) was used as a model to investigate the mechanism of steroidogenic inhibition and to identify the molecular target of BPAF. Read More

Zhonghua Yu Fang Yi Xue Za Zhi 2018 Feb;52(2):175-179

Department of Safety Assessment and Research Center for Drug, Pesticide and Veterinary Drug of Jiangsu Province, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China.

This study aimed to investigate the influence of monobutyl phthalate (MBP) on the expressions of epithelial-mesenchymal transition (EMT)-related proteins, migration and invasion of mouse Leydig tumor cells (MLTC-1) cells. After exposed to different doses of MBP (0、10(-7)、10(-6), 10(-5), 10(-4), 10(-3) mol/L) for 24 h or 48 h, cell viability was determined by 3-(4 5-dimethyl-2-thiazolyl)-2 5-diphenyl-2-H-tetrazolium bromide (MTT) assay. Expressions of vimentin, E-cadherin, N-cadherin and Snail proteins related to EMT were detected by Western blot. Read More

Endocrinology 2018 02;159(2):1130-1146

Research Institute of the McGill University Health Centre and Department of Medicine, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.

The outer mitochondrial membrane translocator protein (TSPO) binds cholesterol with high affinity and is involved in mediating its delivery into mitochondria, the rate-limiting step in hormone-induced steroidogenesis. Specific ligand binding to TSPO has been shown to initiate steroid formation. However, recent studies of the genetic deletion of Tspo have provided conflicting results. Read More

World J Urol 2018 Mar 11;36(3):427-433. Epub 2017 Dec 11.

Department of Urology and Renal Transplantation, University Hospital of Besancon, 3 Boulevard Fleming, 25000, Besancon, France.

Objective: To compare the oncological outcomes of testicle-sparing surgery (TSS) and radical orchiectomy (RO) in patients with Leydig cell tumor (LCT) of the testis.

Patients And Methods: A multicenter retrospective clinical study was conducted in 12 centers in France. All the patients with histologically proven LCT were included and analyzed according to treatment (organ-sparing surgery or radical orchiectomy). Read More

Cancer Res Treat 2018 Oct 24;50(4):1452-1457. Epub 2017 Nov 24.

Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Microcystic stromal tumor (MCST) is a rare subtype of sex cord-stromal neoplasm. Tumors from all 31 previously reported cases were located in the ovary. Herein, we present a unique case of a right-side testicular tumor in a 33-year-old Chinese male. Read More

Case Rep Oncol 2017 Sep-Dec;10(3):832-839. Epub 2017 Sep 15.

Cancer Treatment Centers of America, Southwestern Regional Center, Tulsa, OK, USA.

Introduction: Testicular cancer is the most common malignancy in men aged 15-40 years [Bols et al.: Philadelphia, Wolters Kluwer, Lippincott Williams & Wilkins, 2011]. Its incidence comprises 0. Read More

J Clin Endocrinol Metab 2017 12;102(12):4411-4416

Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Denmark.

Context: Testotoxicosis is an autosomal-dominant, male-limited disorder. Activating mutations in the luteinizing hormone receptor gene (LHCGR) cause high autonomous testosterone secretion, resulting in early-onset peripheral precocious puberty. Little is known about long-term consequences of testotoxicosis. Read More

Tunis Med 2016 Dec;94(12):897

Eur Radiol 2018 Feb 30;28(2):554-564. Epub 2017 Aug 30.

Testis-Unit (TU), Policlinico Umberto I, Rome, Italy.

Objectives: To explore the role of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), using semiquantitative and quantitative parameters, and diffusion-weighted (DW) MRI in differentiating benign from malignant small, non-palpable solid testicular tumours.

Methods: We calculated the following DCE-MRI parameters of 47 small, non-palpable solid testicular tumours: peak enhancement (PE), time to peak (TTP), percentage of peak enhancement (Epeak), wash-in-rate (WIR), signal enhancement ratio (SER), volume transfer constant (K), rate constant (K), extravascular extracellular space volume fraction (V) and initial area under the curve (AUC). DWI signal intensity and apparent diffusion coefficient (ADC) values were evaluated. Read More

Pan Afr Med J 2017 19;27:51. Epub 2017 May 19.

College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.

Sex cord tumors of the testis in post pubertal men are rare. Mixed leydig-Sertoli-Granulosa sex cord tumors are exceptionally rare. To the best of our knowledge there are only three reported similar cases in the literature. Read More

Hum Pathol 2017 09 21;67:85-93. Epub 2017 Jul 21.

Department of Pathology, Faculty of Medicine in Plzen, 30460, Charles University in Prague, 11636, Biopticka laborator s.r.o., Plzen, 30100, Czech Republic.

Primary signet ring stromal tumor of the testis (PSRSTT) is an extremely rare tumor described only twice in the literature. Pancreatic-analogue solid pseudopapillary neoplasm (SPN) of the testis is a recently reported entity with morphological overlap with PSRSTT. We reviewed our files to find all cases of PSRSTT to better characterize this entity. Read More

Ir J Med Sci 2018 May 19;187(2):323-326. Epub 2017 Jul 19.

Department of Urology, Mercy University Hospital, Cork, Ireland.

Background: Leydig cell tumour (LCT) of the testis is a rare histological subtype of stromal tumours, accounting for 1 to 3% of testicular neoplasms. The natural history of LCT is poorly understood.

Aims: The aim of this study was to assess the incidence and natural history of Leydig cell tumours (LCT) of the testes. Read More

J Indian Assoc Pediatr Surg 2017 Jul-Sep;22(3):181-183

Department of Pediatric Surgery, IPGME and R, Kolkata, India.

Leydig cell tumors (LCTs) are rare testicular tumors. Incidence is 1%-3% of all testicular neoplasms, bilateral in 10%. They are frequently hormonally active, leading to feminizing or virilizing syndromes. Read More

Arch Esp Urol 2017 Jul;70(6):617-620

Servicio de Urología.Hospital Universitario de Getafe. Madrid. España.

Objetive: To describe the adult type granulosa cell testicular tumors (classified as sex cordstromal tumor) due to their behavior, hardly known with a small number of cases reported.

Method: We report a new case of a 59-year-old man presenting an adult type granulosa cell tumor of the testis (AGCTT), painless, with a 3.3 centimeter intratesticular heterogeneous mass on ultrasound, with solid and cystic areas. Read More

Reproduction 2017 10 4;154(4):363-374. Epub 2017 Jul 4.

Institute for Veterinary AnatomyHistology and Embryology, Justus Liebig University, Giessen, Germany.

This study aimed to define the expression patterns of HENMT1 and PIWI proteins in human testis and investigate their association with transposon expression, infertility sub-type or development of testicular germ cell tumours (TGCTs). Testis biopsies showing normal spermatogenesis were used to identify normal localisation patterns of HENMT1 and PIWIL1 by immunolocalisation and RT-PCR after laser microdissection. 222 testis biopsies representing normal spermatogenesis, hypospermatogenesis, spermatogenic arrests, Sertoli cell-only (SCO) tumours and TGCTs were analysed by RT-qPCR for expression of and Additionally, -overexpressing TCam2 seminoma cell lines were analysed for the same parameters by RT-qPCR. Read More

Pan Afr Med J 2017 4;26:198. Epub 2017 Apr 4.

Mohamed VI Center of Cancer Treatment, Morocco.

Granulosa cell tumors is classified into juvenile and adult types and comprise less than 5% of ovarian tumors in women and are much rarer in men which only 45 have been previously reported. We report here a 40-year young man with a left testicular adult type granulosa cell tumor. The tumor measured 5. Read More

J Clin Diagn Res 2017 May 1;11(5):XD01-XD02. Epub 2017 May 1.

Assistant Professor, Department of Pathology, Acharya Harihara Regional Cancer Centre, Cuttack, Odisha, India.

Sertoli-Leydig Cell Tumour (SLCT) is included under sex-cord stromal tumour of testis or ovary. Ovarian pathology is an extremely rare entity constituting less than 0.5% of all ovarian neoplasms. Read More

Oncology (Williston Park) 2017 06;31(6):484, 489-91

Radiographics 2017 Jul-Aug;37(4):1085-1098. Epub 2017 Jun 2.

From the Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Md (J.M.); American Institute for Radiologic Pathology, 1100 Wayne Ave, Suite 1020, Silver Spring, MD 20910 (J.M., D.J.W.); Department of Radiology, Johns Hopkins School of Medicine, Washington, DC (D.J.W., A.L.A.); and Joint Pathology Center, Silver Spring, Md (I.A.S.).

Testicular seminoma is the most common malignant tumor of the testis. It classically manifests as a painless mass. Radiologic evaluation with high-frequency ultrasonography (US) is critical for diagnosis. Read More

Toxicol Appl Pharmacol 2017 08 26;329:85-95. Epub 2017 May 26.

Department of Regulatory Safety, Drug Safety & Metabolism, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom; AstraZenweca, Department of Non-Clinical Drug Safety, Mundipharma Research Ltd., Cambridge, United Kingdom.

Naloxegol is an opioid antagonist which has been developed for the treatment of patients with opioid induced constipation. In the nonclinical safety program naloxegol was shown to have a very benign toxicity profile. In the rat, but not the mouse, 2-year carcinogenicity study a change in tumour pattern with an increase in testicular Leydig cell tumours (LCT) was observed after dosing at high (supra-pharmacological) concentrations. Read More

Urology 2017 Sep 24;107:226-228. Epub 2017 May 24.

Department of Pediatric Urology, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA.

Large-cell calcifying Sertoli cell tumor (LCCSCT) of the testis is an exceptionally rare lesion, found sparsely in any medical literature. There is a correlation between this entity and Peutz-Jeghers syndrome and Carney complex (40% of tumors). The remaining 60% of tumors are sporadic. Read More

Presse Med 2017 Jun 23;46(6 Pt 1):572-578. Epub 2017 May 23.

Ibn El Jazzar teaching hospital, Les Aghlabides surgical division, urology department, 3100 Kairouan, Tunisia.

Testicular tumor of adrenogenital syndrome is a rare and benign anomaly usually presenting as bilateral testicular masses. It is the most important cause of infertility in adult male congenital adrenal hyperplasia. Distinction between testicular tumors of adrenogenital syndrome and Leydig cell tumors can be problematic; it is based on clinical, histopathologic, immunohistochemical and endocrine features. Read More

Pathologe 2017 May;38(3):209-220

Institut für Pathologie, Universität Innsbruck, Müllerstraße 44, 6020, Innsbruck, Österreich.

Earlier revisions of the WHO classification of testicular tumors, which was originally published in 1977, contained only minor additions. In the WHO 2016 classification, in contrast, germ cell tumors are split into two major groups based on their distinct pathohistogenesis, i. e. Read More

Hum Pathol 2017 07 23;65:1-14. Epub 2017 Apr 23.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202; Department of Urology, Indiana University School of Medicine, Indianapolis, IN 46202. Electronic address:

Sex cord-stromal tumors (SCSTs) are the second most frequent category of testicular neoplasms, accounting for approximately 2% to 5% of cases. Both genetic and epigenetic factors account for the differences in frequency and histologic composition between testicular and ovarian SCSTs. For example, large cell calcifying Sertoli cell tumor and intratubular large cell hyalinizing Sertoli cell neoplasia occur in the testis but have not been described in the ovary. Read More

Acta Vet Scand 2017 Apr 11;59(1):20. Epub 2017 Apr 11.

Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon, 200-701, Republic of Korea.

Background: Mammary gland tumors are the most common tumors in sexually intact female dogs; however, they are rare in male dogs. This study was conducted to investigate the relationship between sexual hormones and mammary gland tumors in a male dog.

Case Presentation: A 13-year-old, intact male Cocker Spaniel presented to the Veterinary Teaching Hospital of Kangwon National University, Republic of Korea, with an acute right ruptured caudal abdominal mass. Read More

Zhonghua Bing Li Xue Za Zhi 2017 Apr;46(4):249-254

JOINN Laboratories, Beijing 100176, China.

To investigate the spontaneous neoplastic lesions and their incidences in Sprague-Dawley (SD) and Wistar rats, and to accumulate background data for carcinogenicity studies. One hundred and eighty SD rats and 240 Wistar rats (4-week old) , half in each sex, were used in this study. The rats were housed routinely under specific pathogen-free environment and euthanized after 104 weeks. Read More

Diagn Cytopathol 2017 Jul 9;45(7):634-639. Epub 2017 Mar 9.

Department of Pathology, University of Alabama, Birmingham, Alabama, 35294.

Carney Complex (CNC) is a rare autosomal dominant condition with characteristic clinical presentation, tumor development, and unique genetic mutation. We present a unique case and literature review of CNC in which two neoplasms characteristic of this complex were initially diagnosed through cytological fine needle aspirate specimens, leading to the identification of CNC, with subsequent surgical and cytogenetic confirmation. Diagn. Read More

J Pediatr Urol 2017 Apr 10;13(2):158-163. Epub 2017 Feb 10.

Department of Paediatric Surgery, Monash Children's Hospital, Melbourne, Australia.

Introduction: Leydig cell hyperplasia (LCH) and Leydig cell tumours (LCTs) in children are rare, typically presenting with precocious puberty. Previously, orchidectomy was the routine management; however, more recently, testis-sparing surgery has been performed with good results. We present a series of unusual presentations of LCH, raising new management questions, and a review of the literature regarding LCH and LCT in children. Read More

Virchows Arch 2017 Apr 16;470(4):421-428. Epub 2017 Feb 16.

Gemeinschaftspraxis Pathologie, Am Fuchsengraben 3, 82319, Starnberg, Germany.

The WHO classification of testis tumours includes the group of sex cord-stromal tumours. They are divided into several histological types, i.e. Read More

Pediatrics 2016 11;138(5)

Departments of Pediatrics, and.

Leydig cell tumors (LCTs) are rare cord-stromal tumors that may occur in testis or ovaries and may produce androgens or estrogens. The majority has been found in men between the ages of 20 and 60 years. Adults with androgen-secreting LCTs are usually asymptomatic; feminizing syndromes may result from the production of estradiol or the peripheral aromatization of testosterone. Read More

Hum Pathol 2017 03 8;61:181-189. Epub 2016 Dec 8.

Departments of Pathology and Laboratory Medicine, Veterans Administration Health Care Service, Minneapolis, MN 55417; Departments of Pathology and Laboratory Medicine, University of Minnesota School of Medicine, Minneapolis, MN 55455.

Sertoli cell (SC) and sertoliform tumors of the testis are very uncommon; for this reason their differential diagnosis and classification can be challenging. We applied an extensive immunophenotypic panel that included androgenic hormones, enzymes and receptors, neuroendocrine, lineage and genitourinary markers to a series of these lesions to determine if and which immunostains can aid in their diagnostic workup. Study cases included: 2 androgen insensitivity syndrome-associated SC adenomas, 3 SC tumors (SCT) not otherwise specified (SCT-NOS), 3 sclerosing SCT, 2 large cell calcifying SCT, 1 SCT with heterologous sarcomatous elements, 1 malignant SCT, and 1 sertoliform rete testis adenoma (sertoliform RTA). Read More

Actas Urol Esp 2017 Apr 25;41(3):146-154. Epub 2016 Nov 25.

Departamento de Urología, IRCCS Policlinico San Donato, San Donato Mse, Milán, Italia.

Introduction: The gold standard for Leydig cell tumours (LCTs) is still considered radical orchidectomy, but testis sparing surgery (TSS) in conjunction with intraoperative frozen section (FSE) has been recently attempted with promising results.

Acquisition Of Evidence: Studies were identified by searching electronic databases. A bibliographic search covering the period from January 1980 to December 2012 was conducted using PubMed/MEDLINE and EMBASE database. Read More

J Clin Res Pediatr Endocrinol 2017 Jun 20;9(2):168-171. Epub 2016 Nov 20.

Ankara University Faculty of Medicine, Department of Pediatrics, Ankara, Turkey, Phone: +90 506 621 39 01 E-mail:

Peutz-Jeghers syndrome (PJS) is inherited as an autosomal dominant trait characterized by multiple gastrointestinal hamartomatous polyps, mucocutaneous pigmentation, and an increased risk of neoplasm. Large-cell calcifying Sertoli cell tumor (LCCSCT) is a kind of sex cord-stromal tumor which may co-exist with PJS and which is characterized radiologically by calcification foci within the testes. Surgical treatment options for this tumor range from testis-preserving surgery to radical orchiectomy. Read More

Histopathology 2017 Mar 23;70(4):513-521. Epub 2016 Dec 23.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

The World Health Organization (WHO) released a new tumour classification for the genitourinary system in early 2016 after consensus by pathologists with expertise in these organs. It utilized the framework of the 2004 classification, and incorporated the most up-to-date information concerning these tumours. In testicular tumours, the majority of the changes occurred in the nomenclature and classification of germ cell tumours; however, several modifications were also made for non-germ cell tumours. Read More

J Pediatr Urol 2017 Feb 11;13(1):51.e1-51.e4. Epub 2016 Oct 11.

Department of Pediatric Surgery, Division of Pediatric Urology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.

Objective: The aim was to analyze testis-sparing surgical procedures in boys with Leydig cell pathologies.

Study Design: The hospital records of four boys with Leydig cell hyperplasia who underwent testis-sparing surgery for testicular masses between 2000 and 2012 were analyzed retrospectively. Tumor markers were evaluated and all boys underwent scrotal ultrasonography preoperatively. Read More

Virchows Arch 2016 Dec 1;469(6):679-686. Epub 2016 Oct 1.

Department of Pathology and Laboratory Medicine, Veterans Administration Health Care System, One Veterans Drive, Minneapolis, MN, 55417, USA.

We performed a detailed morphologic, immunophenotypic, and endocrine characterization of neoplastic and non-neoplastic lesions of androgen-producing cells known to harbor or lack Reinke crystals (RCs) with an aim to provide further insight into the nature of these cells and crystals. Study cases were selected from the files of participating hospitals and subclassified according to current classifications: 20 with Leydig cell tumors (LCTs), 2 with testicular adrenal rest tumors (TARTs), 2 with testicular tumors of adrenogenital syndrome (TTAGS), and 2 with androgen insensitivity syndrome (AIS). An extensive immunophenotypic panel including markers used in sex cord-stromal cell tumors, androgen hormones, enzymes, and receptors was applied to the cases and 10 non-tumoral adrenal glands. Read More

Tierarztl Prax Ausg G Grosstiere Nutztiere 2016 Dec 21;44(6):371-378. Epub 2016 Sep 21.

Dr. med. vet. Théophile Vissiennon, DVM, FTA für Pathologie, Tierpathologie Dr. Th. Vissiennon, Postfach 301453, 04254 Leipzig, Germany, Email:

Congenital testicular tumours are seldom reported in bovine species. This case report describes the clinical, sonographical, haematological, pathomorphological and immunohistological features of a Sertoli cell tumour in a neonatal German Holstein calf. Microscopically, the enlarged testicle was composed of neoplastic cells, which were packed in well-formed tubules. Read More

J Urol 2016 10 13;196(4):1257. Epub 2016 Jul 13.