5,949 results match your criteria Testicular Seminoma


Bifocal germinoma in a patient with 16p11.2 microdeletion syndrome.

Endocrinol Diabetes Metab Case Rep 2019 Feb 7;2019. Epub 2019 Feb 7.

Department of Endocrinology, Diabetes and Metabolism.

Intracranial germinomas are rare tumors affecting mostly patients at young age. Therefore, molecular data on its etiopathogenesis are scarce. We present a clinical case of a male patient of 25 years with an intracranial germinoma and a 16p11. Read More

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http://dx.doi.org/10.1530/EDM-18-0149DOI Listing
February 2019
7 Reads

Factors that impact the outcomes in testicular germ cell tumors in low-middle-income countries.

Med Oncol 2019 Feb 6;36(3):28. Epub 2019 Feb 6.

Department of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, 600020, India.

Germ cell tumors (GCTs) are one of the most common tumors in adolescents and young adults. There is paucity of data on GCT from low-middle-income countries (LMIC). The present study was conducted to assess the demographic features, clinical manifestations, pathology, and outcomes of GCT patients treated at our center. Read More

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http://dx.doi.org/10.1007/s12032-019-1252-6DOI Listing
February 2019
1 Read
2.058 Impact Factor

Preservation of Ejaculatory Function After Postchemotherapy Retroperitoneal Lymph Node Dissection (PC-RPLND) in Patients With Testicular Cancer: Template vs. Bilateral Resection.

Front Surg 2018 17;5:80. Epub 2019 Jan 17.

Department of Urology, Medical Faculty, University of Duesseldorf, Duesseldorf, Germany.

Post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) plays a crucial role in treatment of metastatic non-seminomatous germ cell cancer. To evaluate the functional outcome regarding the preservation of ejaculatory function comparing a bilateral vs. unilateral template resection in PC-RPLND patients. Read More

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http://dx.doi.org/10.3389/fsurg.2018.00080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345078PMC
January 2019
1 Read

Readressing the rationale of irradiation in Stage I seminoma guidelines: A critical essay.

BJU Int 2019 Jan 25. Epub 2019 Jan 25.

Department of Radiation Oncology, Leuven University Hospital, Leuven, Belgium.

Germ cell tumors (GCT), accounting for 95% of malignant testicular tumors, can be divided into two groups: seminoma (SGCT) and non-seminoma (NSGCT). Seminomas typically arise in men in the fourth decade of life, compromising 60% of the GCT. At diagnosis, approximately 75% present with local disease (Stage I); 15% is detected with metastatic regional lymph nodes (Stage II) and 5-10% present with juxtaregional or visceral metastasis (Stage III) . Read More

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http://dx.doi.org/10.1111/bju.14686DOI Listing
January 2019
2 Reads

Testicular germ cell tumor: a comprehensive review.

Cell Mol Life Sci 2019 Jan 22. Epub 2019 Jan 22.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing, 100101, China.

Testicular tumors are the most common tumors in adolescent and young men and germ cell tumors (TGCTs) account for most of all testicular cancers. Increasing incidence of TGCTs among males provides strong motivation to understand its biological and genetic basis. Gains of chromosome arm 12p and aneuploidy are nearly universal in TGCTs, but TGCTs have low point mutation rate. Read More

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http://dx.doi.org/10.1007/s00018-019-03022-7DOI Listing
January 2019
3 Reads

Management of Residual Mass in Germ Cell Tumors After Chemotherapy.

Curr Oncol Rep 2019 Jan 21;21(1). Epub 2019 Jan 21.

Department of Urology, Indiana University School of Medicine, 535 Barnhill Dr., Indianapolis, IN, 46202, USA.

Purpose Of Review: The purpose of this review is to educate medical oncologists on the management of patients with residual germ cell tumors and the role of surgical resection after platinum-based chemotherapy.

Recent Findings: Patients with non-seminomatous testicular cancer and residual enlarged retroperitoneal lymph nodes > 1 cm following induction chemotherapy with normal tumor markers should undergo a post-chemotherapy retroperitoneal lymph node dissection. All patients with primary mediastinal non-seminoma should undergo surgical resection of the mediastinal mass post-chemotherapy. Read More

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http://dx.doi.org/10.1007/s11912-019-0758-6DOI Listing
January 2019
2 Reads

[A CASE WITH LATE RECURRENCE OF EXTRAGONADAL GERM CELL TUMOR].

Nihon Hinyokika Gakkai Zasshi 2018 ;109(1):40-44

Department of Urology, Nagoya University Graduate School of Medicine.

A 61-year-old man had undergone resection of teratoma with a histological component of seminoma occurring in the anterior mediastinum at 26 years of age in 1978, followed by radiation treatment to the resected area. He had a recurrence tumor in the left retroperitoneum 2 years later, which was resected combined with left nephrectomy and was proved to be the same pathology as the initial tumor. At 36 years after the initial treatment, the tumor recurred in the right lung. Read More

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http://dx.doi.org/10.5980/jpnjurol.109.40DOI Listing
February 2019
1 Read

True hermaphroditism with seminoma: A case report.

Mol Clin Oncol 2019 Jan 8;10(1):97-100. Epub 2018 Nov 8.

Department of Urology, Peking University Shenzhen Hospital, Institute of Urology, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China.

The aim of the present study was to discuss the diagnosis and treatment of a patient with true hermaphroditism complicated by seminoma. The patient was a 35-year-old man who was admitted to the Peking University Shenzhen Hospital with a retractable mass in the left inguinal region for 20 years. A computed tomography examination revealed right cryptorchidism. Read More

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http://dx.doi.org/10.3892/mco.2018.1760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313949PMC
January 2019
1 Read

Testicular Seminoma in a Transgender Woman: A Case Report.

LGBT Health 2019 Jan;6(1):40-42

3 Department of Obstetrics and Gynecology, Denver Health, Denver, Colorado.

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http://dx.doi.org/10.1089/lgbt.2018.0173DOI Listing
January 2019
1 Read

c-Src Recruitment is Involved in c-MET-Mediated Malignant Behaviour of NT2D1 Non-Seminoma Cells.

Int J Mol Sci 2019 Jan 14;20(2). Epub 2019 Jan 14.

Department of Anatomy, Histology, Forensic-Medicine and Orthopedics, "Sapienza" University of Rome, 00161 Rome, Italy.

c-MET pathway over-activation is the signature of malignancy acquisition or chemotherapy resistance of many cancers. We recently demonstrated that type II Testicular Germ Cell Tumours (TGCTs) express c-MET receptor. In particular, we elucidated that the non-seminoma lesions express c-MET protein at higher level, compared with the seminoma ones. Read More

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http://dx.doi.org/10.3390/ijms20020320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358843PMC
January 2019
1 Read

New Anti-Cancer Strategies in Testicular Germ Cell Tumors.

Recent Pat Anticancer Drug Discov 2019 Jan 11. Epub 2019 Jan 11.

Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Scuola di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli #39;Federico II', Naples. Italy.

Background: The most common solid malignancy of young men aged 20 to 34 years is testicular germ cell tumor. In addition, the incidence of these tumors has significatively increased throughout the last years. Testicular germ cell tumors are classified into seminoma and nonseminoma germ cell tumors, which take in yolk sac tumor, embryonal cell carcinoma, choriocarcinoma, and teratoma. Read More

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http://www.eurekaselect.com/168893/article
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http://dx.doi.org/10.2174/1574892814666190111120023DOI Listing
January 2019
14 Reads

Differential Zika Virus Infection of Testicular Cell Lines.

Viruses 2019 Jan 9;11(1). Epub 2019 Jan 9.

Biology of Vector-Borne Viruses Section, Laboratory of Virology, Rocky Mountain Laboratories, NIAID/NIH, Hamilton, MT 59840, USA.

Background: Zika virus is a mosquito-borne flavivirus responsible for recent outbreaks of epidemic proportions in Latin America. Sexual transmission of the virus has been reported in 13 countries and may be an important route of infection. Sexual transmission of ZIKV has mostly been male-to-female, and persistence of viral RNA in semen for up to 370 days has been recorded. Read More

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http://dx.doi.org/10.3390/v11010042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356326PMC
January 2019
1 Read

Current controversies on the role of lymphadenectomy for testicular cancer for the journal: Urologic Oncology: Seminars and Original Investigations for the special seminars section on the role of lymphadenectomy for urologic cancers.

Urol Oncol 2019 Jan 7. Epub 2019 Jan 7.

Department of Urology, Indiana University School of Medicine, Indianapolis, IN.

The role of surgery in the locoregional management of many solid tumors has long been established. For testicular cancer, the incorporation of lymphadenectomy has played an important part in generating long-term survival outcomes in excess of 90% for germ cell tumor patients. In this review, we address several clinical scenarios in which lymphadenectomy at times is underutilized, and others ill advised. Read More

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http://dx.doi.org/10.1016/j.urolonc.2018.12.021DOI Listing
January 2019
2 Reads

Leptin Receptor as a Potential Target to Inhibit Human Testicular Seminoma Growth.

Am J Pathol 2019 Jan 2. Epub 2019 Jan 2.

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy. Electronic address:

Although in past decades the adipokine leptin and its own receptor have been considered as significant cancer biomarkers, their potential involvement in human testicular seminoma growth and progression remains unexplored. Here, we showed that the expression of leptin and its receptor was significantly higher in human testicular seminoma compared with normal adult testis. Human seminoma cell line TCam-2 also expressed leptin along with the long and short isoforms of leptin receptor, and in response to leptin treatment showed enhanced activation of its downstream effectors. Read More

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http://dx.doi.org/10.1016/j.ajpath.2018.11.012DOI Listing
January 2019
3 Reads

Ambiguous presentation of an intra-abdominal testicular seminoma in a 40-year-old man: a case report.

J Med Case Rep 2019 Jan 4;13(1). Epub 2019 Jan 4.

St Elizabeth Catholic General Hospital and Cardiac Centre, Shisong, Northwest Region, Cameroon.

Background: Cryptorchidism is the most common congenital malformation of the male genitourinary tract. The cryptorchid testis is most often located in the inguinal canal; however, intra-abdominal locations are not rare. The risk of malignancy in an undescended testis is 10% with the highest risk in an intra-abdominal testis. Read More

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http://dx.doi.org/10.1186/s13256-018-1917-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320594PMC
January 2019
1 Read

New Insights on the Mechanisms Affecting Fertility in Men with Non-Seminoma Testicular Cancer before Cancer Therapy.

World J Mens Health 2018 Dec 21. Epub 2018 Dec 21.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

Purpose: Patients with non-seminoma testicular cancer (NSTC) cancer can be subfertile or infertile, and present reduced sperm quality, but the underlying mechanisms are unknown. The aim of this study was to compare the sperm proteome of patients with NSTC, who cryopreserved their sperm before starting cancer treatment, with that from healthy fertile men.

Materials And Methods: Semen volume, sperm motility and sperm concentration were evaluated before the cryopreservation of samples from patients with NSTC (n=15) and the control group (n=15). Read More

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http://dx.doi.org/10.5534/wjmh.180099DOI Listing
December 2018
2 Reads

Paraneoplastic recurrent tumefactive demyelination in a 62-year-old man with metastatic seminoma.

Neurol Neuroimmunol Neuroinflamm 2019 Jan 13;6(1):e527. Epub 2018 Dec 13.

Ottawa Hospital, Division of Neurology (S.T., P.R.B.); The Children's Hospital of Eastern Ontario (I.H.); The Ottawa Hospital (J.W.), Department of Pathology and Laboratory Medicine; and The Ottawa Hospital Research Institute (P.R.B.), ON, Canada.

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http://dx.doi.org/10.1212/NXI.0000000000000527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299676PMC
January 2019
1 Read

[Temporary Bypass with 5-Fr Catheter for Reconstruction of Superior Vena Cava].

Kyobu Geka 2018 12;71(13):1077-1080

Division of Thoracic Surgery, Kobe University, Kobe, Japan.

A 21-year-old man was referred to our hospital because of an abnormal shadow on a routine chest radiogram. Enhanced computed tomography showed an 83×74 mm mass in the anterior mediastinum, with invasion of the superior vena cava (SVC). Surgical resection with sternotomy was performed. Read More

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December 2018
7 Reads

A Qualitative Analysis of the Impact of Carboplatin AUC 10 on Physical, Work Functioning and Bone Marrow Toxicity Among Seminoma Patients - A Single-centre Experience.

In Vivo 2019 Jan-Feb;33(1):233-237

Department of Medical Oncology, Mount Vernon Cancer Centre, Northwood, U.K.

Background: Single-agent carboplatin at area under the curve 10 (AUC10) is an effective treatment for metastatic seminoma. As far as we are aware of, there have been no studies reporting its effects on short-term quality of life. The objective was to study the efficacy, safety and tolerability, using health-related quality of life, of carboplatin AUC10 chemotherapy in patients with metastatic seminoma. Read More

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http://iv.iiarjournals.org/lookup/doi/10.21873/invivo.11465
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http://dx.doi.org/10.21873/invivo.11465DOI Listing
October 2018
9 Reads

Pure Seminoma and Concurrent Aggressive Lymphoma: Case Report of a Patient With Persistent Müllerian Duct Syndrome.

Clin Genitourin Cancer 2018 Dec 5. Epub 2018 Dec 5.

Department of Medical Oncology, Centre Hospitalier Lyon Sud, Institut de cancérologie des Hospices Civils de Lyon (IC-HCL), Pierre-Bénite, France; UMR INSERM 1052, CNRS 5286, Centre de recherche en cancérologie de Lyon (CRCL), Lyon, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15587673183077
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http://dx.doi.org/10.1016/j.clgc.2018.11.019DOI Listing
December 2018
8 Reads

cd44 deletion suppresses atypia in the precancerous mouse testis.

Mol Carcinog 2018 Dec 23. Epub 2018 Dec 23.

Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.

Loss-of-function of RHAMM causes hypofertility and testicular atrophy in young mice, followed by germ cell neoplasia in situ (GCNIS) of the testis, cellular atypia, and development of the testicular germ cell tumor (TGCT) seminoma. These pathologies reflect the risk factors and phenotypes that precede seminoma development in humans and-given the high prevalence of RHAMM downregulation in human seminoma-link RHAMM dysfunction with the aetiology of male hypofertility and GCNIS-related TGCTs. The initiating event underlying these pathologies, in RHAMM mutant testis, is premature displacement of undifferentiated progenitors from the basal compartment. Read More

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http://dx.doi.org/10.1002/mc.22961DOI Listing
December 2018
4 Reads

Loss of Nuclear Functions of HOXA10 Is Associated With Testicular Cancer Proliferation.

Front Oncol 2018 7;8:594. Epub 2018 Dec 7.

Department of Urologic Sciences, Vancouver Prostate Centre, The University of British Columbia, Vancouver, BC, Canada.

HOXA10 is a key transcriptional factor that regulates testis development as reported from previous transgenic mouse models and human inherited diseases. However, whether it also plays important roles in promoting the development of testicular cancer is not well-understood. To study the expression of HOXA10 and its regulated signaling pathways in testicular cancers. Read More

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http://dx.doi.org/10.3389/fonc.2018.00594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292994PMC
December 2018
3 Reads

Incidence of testicular tumor subtypes according to the updated WHO classification, North Rhine-Westphalia, Germany, 2008-2013.

Andrology 2018 Dec 21. Epub 2018 Dec 21.

Cancer Registry of North Rhine-Westphalia, Muenster, Germany.

Background: In 2016, the WHO introduced an updated classification for testicular tumors. The application of this updated classification to cancer registry data requires some recoding of tumors.

Objectives: The aim of this study was to provide up-to-date population-based incidence estimates of subtypes of testicular germ cell tumors (TGCT) according to the updated classification. Read More

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http://dx.doi.org/10.1111/andr.12565DOI Listing
December 2018
1 Read

5-Azacitidine Exerts Prolonged Pro-Apoptotic Effects and Overcomes Cisplatin-Resistance in Non-Seminomatous Germ Cell Tumor Cells.

Int J Mol Sci 2018 Dec 21;20(1). Epub 2018 Dec 21.

Department of Oncology, Hematology and Bone Marrow Transplantation with Division of Pneumology, University Medical Center Eppendorf, 20246 Hamburg, Germany.

Despite high cure rates, about 20% of patients with advanced germ cell tumors (GCTs) fail cisplatin-based chemotherapy. High levels of DNA methylation have been identified in GCTs and linked to cisplatin resistance. Here, we examined the effects of DNA hypomethylating 5-azacitidine (5-aza) on two embryonal carcinoma cell lines (NCCIT, 2102Ep) and their cisplatin-resistant isogenic derivatives. Read More

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http://dx.doi.org/10.3390/ijms20010021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337423PMC
December 2018
1 Read

Rete Testis Invasion Is Consistent With Pathologic Stage T1 in Germ Cell Tumors.

Am J Clin Pathol 2018 Dec 20. Epub 2018 Dec 20.

Medical College of Wisconsin, Milwaukee.

Objectives: Rete testis invasion by germ cell tumors is frequently concomitant with lymphovascular or spermatic cord invasion (LVI/SCI); independent implications for staging are uncertain.

Methods: In total, 171 seminomas and 178 nonseminomatous germ cell tumors (NSGCTs; 46 had 1%-60% seminoma component) came from five institutions. Metastatic status at presentation, as a proxy for severity, was available for all; relapse data were unavailable for 152. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/ajcp/aqy168DOI Listing
December 2018
2 Reads

Persistent Mullerian Duct Syndrome with Testicular Seminoma in Transverse Testicular Ectopia.

J Hum Reprod Sci 2018 Jul-Sep;11(3):300-302

Department of Pathology, BJGMC, Pune, Maharashtra, India.

Persistent Mullerian Duct Syndrome (PMDS) is a disorder of male pseudohermaphroditism characterized by the persistence of Mullerian duct derivatives (uterus, fallopian tubes, and upper two-third of vagina) in a phenotypically and genotypically male. Transverse testicular ectopia (TTE) is a rare congenital anomaly in which both gonads migrate toward same hemiscrotum. About 150 cases of PMDS and 100 cases of TTE have been reported in previous studies. Read More

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http://dx.doi.org/10.4103/jhrs.JHRS_54_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262660PMC
December 2018
1 Read

The history of urologic pathology: an overview.

Histopathology 2019 Jan;74(1):184-212

Indiana University Medical Center, Indianapolis, IN, USA.

This article begins with the testis and a legendary figure, Sir Astley Cooper, who wrote an early text on the organ. The early 20th century saw the first major development, the description of the seminoma by the French investigator Maurice Chevassu, but the pace of knowledge did not accelerate until after World War II with a major article from the Armed Forces Institute of Pathology (AFIP) by Nathan B. Friedman and Robert A. Read More

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http://doi.wiley.com/10.1111/his.13753
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http://dx.doi.org/10.1111/his.13753DOI Listing
January 2019
8 Reads

Neuroglial Differentiation and Neoplasms in Testicular Germ Cell Tumors Lack Immunohistochemical Evidence of Alterations Characteristic of Their CNS Counterparts: A Study of 13 Cases.

Am J Surg Pathol 2019 Mar;43(3):422-431

Departments of Pathology.

Overgrowth of neuroglial tissue is rare in testicular germ cell tumors and mostly reported as isolated cases. We retrospectively reviewed 13 cases of testicular germ cell tumors from 2 institutions from 1995 to 2018. Hematoxylin and eosin slides were collected and reviewed. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001206DOI Listing
March 2019
3 Reads

Incorporating non-biological factors into the TNM staging system for better prognostication and decision-making in testicular cancer.

World J Urol 2018 Dec 15. Epub 2018 Dec 15.

Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.

Background: We combined county-level socioeconomic status (SES), marital status and insurance status to introduce NBF-stage, which were further incorporated into the American Joint Committee on Cancer (AJCC) TNM staging system to generate an integrated staging system for better prognostication and decision-making for testicular cancer patients.

Methods: 15,324 eligible patients diagnosed with primary testicular cancer between January 1, 2007 and December 31, 2015 were strictly selected from the Surveillance, Epidemiology, and End Results (SEER) database. Independent survival predictors were determined based on Cox proportional hazards model. Read More

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http://link.springer.com/10.1007/s00345-018-2603-1
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http://dx.doi.org/10.1007/s00345-018-2603-1DOI Listing
December 2018
8 Reads

Serum tumor markers and testicular germ cell tumors: a primer for radiologists.

Abdom Radiol (NY) 2018 Dec 11. Epub 2018 Dec 11.

University Hospitals Cleveland Medical Center, 11100 Euclid Ave, Cleveland, OH, 44106, USA.

Serum tumor markers (STMs) play a critical role in the diagnosis, staging and follow-up of both seminomatous and nonseminomatous testicular germ cell neoplasms. Levels of alpha-fetoprotein (AFP), human chorionic gonadotropin (HCG), and lactate dehydrogenase (LDH), especially those measured after orchiectomy, also have implications for patient prognosis. Given that testicular germ cell tumors represent the most common solid tumor in men aged 20-34, radiologists must have familiarity with the clinical utilization and implications of these STMs. Read More

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http://dx.doi.org/10.1007/s00261-018-1846-zDOI Listing
December 2018
15 Reads

Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor.

J Cancer 2018 31;9(23):4440-4448. Epub 2018 Oct 31.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

MPHOSPH1, which is one of the kinesin superfamily proteins, has been reported to play an essential role in the carcinogenesis and progression of several kinds of cancers. MPHOSPH1 has also been suggested to be involved in STAT3 phosphorylation in hepatocellular carcinoma. However, the biological behavior of MPHOSPH1 in testicular germ cell tumors (TGCTs) is unclear at present. Read More

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http://dx.doi.org/10.7150/jca.25279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277652PMC
October 2018
2 Reads

Deep learning for detecting tumour-infiltrating lymphocytes in testicular germ cell tumours.

J Clin Pathol 2019 Feb 5;72(2):157-164. Epub 2018 Dec 5.

Nuffield Department of Surgical Sciences and NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.

Aims: To evaluate if a deep learning algorithm can be trained to identify tumour-infiltrating lymphocytes (TILs) in tissue samples of testicular germ cell tumours and to assess whether the TIL counts correlate with relapse status of the patient.

Methods: TILs were manually annotated in 259 tumour regions from 28 whole-slide images (WSIs) of H&E-stained tissue samples. A deep learning algorithm was trained on half of the regions and tested on the other half. Read More

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http://dx.doi.org/10.1136/jclinpath-2018-205328DOI Listing
February 2019
1 Read

CSE1L participates in regulating cell mitosis in human seminoma.

Cell Prolif 2018 Nov 28:e12549. Epub 2018 Nov 28.

Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objectives: CSE1L has been reported to be highly expressed in various tumours. Testicular germ cell tumours are common among young males, and seminoma is the major type. However, whether CSE1L has functions in the seminoma is unclear. Read More

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http://dx.doi.org/10.1111/cpr.12549DOI Listing
November 2018
1 Read

Delivery of chemotherapy for testicular cancer in routine practice: A population-based study.

Urol Oncol 2018 Nov 23. Epub 2018 Nov 23.

Division of Cancer Care and Epidemiology, Queen's Cancer Research Institute, Kingston, Canada; Department of Oncology, Queen's University, Kingston, Canada; Department of Public Health Sciences, Queen's University, Kingston, Canada. Electronic address:

Introduction: Maintenance of chemotherapy dose intensity is a cornerstone of management in testicular germ cell tumors. We describe chemotherapy delivery and outcomes of patients in routine practice.

Methods: The Ontario Cancer Registry was linked to electronic records of treatment to identify patients diagnosed with testicular cancer treated with orchiectomy and chemotherapy from 2005 to 2010. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10781439183043
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http://dx.doi.org/10.1016/j.urolonc.2018.10.025DOI Listing
November 2018
6 Reads

[French ccAFU guidelines - Update 2018-2020: Testicular germ cell tumors].

Prog Urol 2018 Nov 27;28(12S):S147-S164. Epub 2018 Oct 27.

Comité de cancérologie de l'Association française d'urologie, groupe organes génitaux externes, maison de l'urologie, 11, rue Viète, 75017 Paris, France; Service d'urologie, hôpital européen Georges-Pompidou, université Paris Descartes, AP-HP, 75015 Paris, France.

Objective: To update French guidelines concerning testicular germ cell cancer.

Methods: Comprehensive Medline search between 2016 and 2018 upon diagnosis, treatment and follow-up of testicular germ cell cancer and treatments toxicities. Level of evidence was evaluated. Read More

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http://dx.doi.org/10.1016/j.purol.2018.08.002DOI Listing
November 2018
2 Reads

Active surveillance as a successful management strategy for patients with clinical stage I germ cell testicular cancer.

Clin Transl Oncol 2018 Nov 23. Epub 2018 Nov 23.

Medical Oncology Department, Virgen del Rocío University Hospital, Seville, Spain.

Background: Cancer-specific survival for patients with clinical stage I (CSI) germ cell testicular cancer (GCTC) is outstanding after inguinal orchidectomy regardless the treatment utilized. This study evaluated whether active surveillance (AS) of such patients yielded similar health outcomes to other therapeutic strategies such as adjuvant chemotherapy, radiotherapy or primary retroperitoneal lymphadenectomy as described in the literature.

Patients And Methods: Patients with CSI GCTC were screened between January 2012 and December 2016. Read More

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http://dx.doi.org/10.1007/s12094-018-1990-5DOI Listing
November 2018
10 Reads

Mediastinal seminoma presenting as a neck mass falsely diagnosed as anaplastic thyroid carcinoma: A case report.

Diagn Cytopathol 2018 Nov 23. Epub 2018 Nov 23.

Department of Lab Medicine and Pathology - Histopathology Section, Hamad Medical Corporation, Doha, State of Qatar.

Germ cell tumors can occur in the mediastinum. They account for about 20% of tumors at this location. The majority are located in the anterior mediastinum and usually occur in young adult males. Read More

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http://dx.doi.org/10.1002/dc.24090DOI Listing
November 2018
12 Reads

Thymic inflammatory pseudotumor with multilocular thymic cyst caused by immunoglobulin G4-related disease.

Thorac Cancer 2019 Jan 23;10(1):116-119. Epub 2018 Nov 23.

Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

A 44-year-old man was referred to our hospital after an anterior mediastinal tumor was noted on computed tomography during follow-up observation after left testicular seminoma resection. Chest computed tomography revealed an enhanced mass measuring 33 x 16 x 15 mm at the anterior mediastinum. Chest magnetic resonance imaging revealed high signal intensity on T2-weighted imaging, and F  fluorodeoxyglucose-positron emission tomography showed a maximum standardized uptake of 12. Read More

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http://dx.doi.org/10.1111/1759-7714.12914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312835PMC
January 2019
16 Reads

Lymph node imaging in testicular cancer.

Transl Androl Urol 2018 Oct;7(5):864-874

Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Testicular cancer is a rare malignancy mainly affecting young men. Survival for testicular cancer remains high due to the effectiveness of multimodal treatment options. Accurate imaging is imperative to both treatment and follow-up. Read More

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http://tau.amegroups.com/article/view/20740/21410
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http://dx.doi.org/10.21037/tau.2018.07.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212624PMC
October 2018
13 Reads

Current controversies on the role of retroperitoneal lymphadenectomy for testicular cancer.

Urol Oncol 2018 Nov 13. Epub 2018 Nov 13.

Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

Retroperitoneal lymph node dissection (RPLND) is an important component of the multimodal treatment which cures most patients diagnosed with testicular germ cell tumors. Considering the high cure rates achieved, research focus in recent years has been directed toward improving quality of life and decreasing long-term treatment related sequelae. Consequently, the role of RPLND has evolved over the past 3 decades in both low-stage and advanced testicular cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10781439183035
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http://dx.doi.org/10.1016/j.urolonc.2018.09.009DOI Listing
November 2018
15 Reads

Long non-coding RNA H19 promotes TDRG1 expression and cisplatin resistance by sequestering miRNA-106b-5p in seminoma.

Cancer Med 2018 Dec 14;7(12):6247-6257. Epub 2018 Nov 14.

Department of Urology, The Third Xiangya Hospital of Central South University, Changsha, China.

The role of TDRG1 in tumorigenesis and the progression of seminoma, as well as its role in regulating chemosensitivity of seminoma to cisplatin through the PI3K/Akt/mTOR signaling pathway, has been previously defined. However, the detailed mechanism underlying TDRG1 expression and concomitant chemoresistance conditions are unknown. Furthermore, it has been reported that non-protein-coding RNAs play an important role in a variety of vital processes including cellular chemosensitivity. Read More

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http://doi.wiley.com/10.1002/cam4.1871
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http://dx.doi.org/10.1002/cam4.1871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308085PMC
December 2018
6 Reads

Sentinel Node Biopsy in Clinical Stage I Testicular Cancer Enables Early Detection of Occult Metastatic Disease.

BJU Int 2018 Nov 11. Epub 2018 Nov 11.

Department of Oncological Urology, UMC Utrecht Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.

Objectives: To report the long-term results of the sentinel node approach in clinical stage I testicular tumour patients in our facility.

Patients And Methods: Analysis of 27 consecutive patients suspected of clinical stage I testicular germ cell tumour and treated with a sentinel node procedure at our tertiary referral centre. Sentinel nodes were identified using lymphoscintigraphy with or without single photo emission computed tomography with computed tomography. Read More

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http://doi.wiley.com/10.1111/bju.14618
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http://dx.doi.org/10.1111/bju.14618DOI Listing
November 2018
11 Reads

Molecular Imaging for Evaluation of Viable Testicular Cancer Nodal Metastases.

Curr Urol Rep 2018 Nov 9;19(12):110. Epub 2018 Nov 9.

The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Marburg 144, Baltimore, MD, 21287, USA.

Purpose Of Review: Determining the metastatic viability of suspicious retroperitoneal nodes in testicular cancer with conventional imaging is challenging. The aim of this report is to review recent evidence in the utilization of novel imaging modalities to assess viable testicular cancer nodal metastases.

Recent Evidence: Testicular germ cell tumors (TCGTs) follow a predictable lymphatic metastatic spread to the retroperitoneum. Read More

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http://link.springer.com/10.1007/s11934-018-0863-3
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http://dx.doi.org/10.1007/s11934-018-0863-3DOI Listing
November 2018
13 Reads

βcatenin is a marker of poor clinical characteristics and suppressed immune infiltration in testicular germ cell tumors.

BMC Cancer 2018 Nov 3;18(1):1062. Epub 2018 Nov 3.

2nd Department of Oncology, Faculty of Medicine, Comenius University and National Cancer Institute, Klenova 1, 833 10, Bratislava, Slovak Republic.

Background: WNT/βcatenin (WNTβ) pathway is activated in early stages of embryonic development. We aimed to evaluate the significance of βcatenin in germ cell tumors (GCTs) and explore associations with the inflamed environment.

Methods: Surgical specimens from 247 patients were analyzed. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-4929-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215644PMC
November 2018
4 Reads

Testis sparing surgery for small testicular masses and frozen section assessment.

Cent European J Urol 2018 16;71(3):304-309. Epub 2018 Aug 16.

Department of Urology, Frimley Health NHS Foundation Trust, Wexham Park Hospital Slough, Berkshire, United Kingdom.

Introduction: We present our experience with patients who had suspected testicular masses, managed by a frozen section assessment and testicular sparing surgery.

Material And Methods: We performed a retrospective review of all patients over the last 5 years, who underwent a frozen section assessment and testicular sparing surgery for small testicular lesions. The frozen section assessment was compared with the final histology. Read More

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http://ceju.online/journal/2018/testis-sparing-surgery-Small
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http://dx.doi.org/10.5173/ceju.2018.1695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202623PMC
August 2018
2 Reads

Testicular seminoma in the aged rat visualized by phase-contrast X-ray computed tomography.

Acta Radiol Open 2018 Sep 23;7(10):2058460118806657. Epub 2018 Oct 23.

School of Allied Health Sciences, Kitasato University, Kanagawaken, Japan.

Spontaneously growing testicular seminoma in the aged rat was imaged by one of the most sensitive imaging modalities, namely, phase-contrast X-ray computed tomography (CT) with crystal X-ray interferometry. Phase-contrast X-ray CT clearly depicted the detailed inner structures of the tumor and provided 20× magnified images compared to light-microscopic images. Phase-contrast X-ray CT images are generated based on density variations in the object, whereas pathological images are based on differentiation of cellular structures, such as the cellular nuclei and cytoplasm. Read More

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http://dx.doi.org/10.1177/2058460118806657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202748PMC
September 2018
4 Reads

[Positron emission tomography in germ cell tumors in men : Possibilities and limitations].

Urologe A 2018 Oct 29. Epub 2018 Oct 29.

Klinik für Onkologie, Hämatologie und Knochenmarktransplantation mit Abteilung für Pneumologie, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.

Background: Conventional radiographic imaging may fail to safely distinguish clinical stage I from stage IIA germ cell cancer, to localize isolated tumor marker relapses, and to equivocally identify the viability of postchemotherapy residual masses.

Objectives: To provide an overview of the diagnostic value and limitations of functional imaging by positron emission tomography with 2‑deoxy-2-[fluorine-18]fluoro-D-glucose with computed tomography (F-FDG-PET-CT) in male germ cell cancer.

Materials And Methods: A narrative review based on a literature search of PubMed/MEDLINE for original articles published from 1990-2018 and conference proceedings of ASCO (American Society of Clinical Oncology) and EAU (European Association of Urology) annual meetings 2014-2017 is presented. Read More

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http://link.springer.com/10.1007/s00120-018-0797-x
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http://dx.doi.org/10.1007/s00120-018-0797-xDOI Listing
October 2018
10 Reads

CK7, inhibin, and p63 in testicular germ cell tumor: superior markers of Choriocarcinoma compared to β-hCG.

Hum Pathol 2018 Oct 22. Epub 2018 Oct 22.

Department of Pathology, The Ohio State University Medical Center, 410 W 10(th) Ave., 401 Doan Hall, Columbus, OH 43210. Electronic address:

Choriocarcinoma can be difficult to differentiate from other subtypes of testicular germ cell tumor and can occur unexpectedly in a distant, late metastasis. The aim of this investigation was to identify a marker superior to β-hCG for choriocarcinoma. 62 primary and metastatic testicular germ cell tumors (27 choriocarcinomas, 19 yolk sac tumors, 29 embryonal carcinomas, 28 seminomas, 22 teratomas, 3 epithelioid trophoblastic tumors (ETT)), were analyzed for immunohistochemical expression of CK7, inhibin, p63, and β-hCG. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183039
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http://dx.doi.org/10.1016/j.humpath.2018.10.007DOI Listing
October 2018
9 Reads
2.770 Impact Factor