5,545 results match your criteria Testicular Seminoma

A phase II study assessing the safety and efficacy of ASP1650 in male patients with relapsed refractory germ cell tumors.

Invest New Drugs 2022 Jun 27. Epub 2022 Jun 27.

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Claudin6(CLDN6) is a tight junction protein of claudin-tetraspanin family and is of the earliest molecules expressed in embryonic epithelium. CLDN6 is frequently aberrantly expressed in testicular germ-cell tumors(GCT). ASP1650 is a chimeric-mouse/human-IgG1 antibody directed against CLDN6. Read More

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Metastatic testicular cancer presenting with hematuria and flank pain.

Urol Ann 2022 Apr-Jun;14(2):196-198. Epub 2022 Apr 18.

Department of Urology, University Hospital HM Sanchinarro, HM Hospitales and ROC Clinic, Madrid, Spain.

Testicular cancer (TC) represents 1% of male neoplasms and 5% of urological tumors. Most of seminoma patients and about 55% of patients with nonseminoma TC have stage I disease at diagnosis. TC usually presents with a palpable testicular mass incidentally found by the patient himself or its partner by palpation. Read More

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Association study between polymorphisms in DNA methylation-related genes and testicular germ cell tumor risk.

Cancer Epidemiol Biomarkers Prev 2022 Jun 14. Epub 2022 Jun 14.

University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: Testicular germ cell tumors (TGCTs), histologically classified as seminomas and non-seminomas, are believed to arise from primordial gonocytes, with the maturation process blocked when are subjected to DNA methylation reprogramming. Single-nucleotide polymorphisms (SNPs) in DNA methylation machinery and folate-dependent one-carbon metabolism genes have been postulated to influence the proper establishment of DNA methylation.

Methods: In this pathway-focused investigation we evaluated the association between 273 selected tag SNPs from 28 DNA methylation-related genes and TGCT risk. Read More

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Oleuropein Counteracts Both the Proliferation and Migration of Intra- and Extragonadal Seminoma Cells.

Nutrients 2022 May 31;14(11). Epub 2022 May 31.

Department of Experimental and Clinical Medicine, University of Catanzaro "Magna Græcia", 88100 Catanzaro, Italy.

Recent and growing literature has reported that oleuropein (OLE), the main polyphenol in olive leaf extract, inhibits tumor cell proliferation and reduces the invasiveness properties of cancer cells; therefore, OLE may play a significant role in the development of new drugs for cancer treatment. These antineoplastic properties have been reported in many experimental cancer models, but the effect of OLE on seminoma cells is yet to be evaluated. In the present study, we demonstrate, for the first time, that OLE reduces cell viability in both intra- and extragonadal TCAM-2 and SEM-1 seminoma cells, respectively, in a dose-dependent manner. Read More

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Educational Case: Classic seminoma of the testis.

Acad Pathol 2022 31;9(1):100032. Epub 2022 May 31.

Department of Pathology, UMass Memorial Medical Center, UMass Chan Medical School, Worcester, MA, 01605, USA.

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A massive retroperitoneal mature teratoma from a "burned-out" testicular teratoma and seminoma.

Radiol Case Rep 2022 Aug 2;17(8):2732-2736. Epub 2022 Jun 2.

Riverside Community Hospital, 4445 Magnolia Avenue, Riverside, CA, 92501, USA.

Germ cell tumors are the most common nonhematologic malignancy of young men which often present with metastasis to the retroperitoneum, however a primary retroperitoneal mass should also be considered. The case presented herein reports a 42-year-old male presenting with a massive heterogenous retroperitoneal mass determined to be a mature cystic teratoma. Further investigation revealed a multifocal right testicular mass containing both a viable pure seminoma and a fibrous scar demonstrating germ cell neoplasia in situ thus representing the rare phenomenon of a "burned-out" mixed germ cell testicular tumor. Read More

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Symptomatic burned-out testicular seminoma: A case report.

Int J Surg Case Rep 2022 Jun 26;95:107245. Epub 2022 May 26.

Dept. of Surgery, "Vito Fazzi" Hospital, Piazza Filippo Muratore, 73100 Lecce, Italy. Electronic address:

Introduction And Importance: Burned-out testicular cancer is a rare phenomenon to be taken into account for differential diagnosis in males presenting with retroperitoneal lymphadenopathy.

Case Presentation: A 54-years-old male complaining of abdominal pain over the past several months was found on CT to have a large mass adjacent to the inferior vena cava, with the imaging features of a malignant lymphadenopathy.

Clinical Discussion: The hematologist who evaluated the case suggested a biopsy of the retroperitoneal mass: a seminoma was diagnosed on pathological examination. Read More

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Unusual presentation of an intra-abdominal testicular seminoma in an adult.

Urol Case Rep 2022 Jul 20;43:102119. Epub 2022 May 20.

La Rabta Hospital: Department of Urology, 1007, Rue Jbal Lakhdhar, Tunis, Tunisia.

Intra-abdominal testicular tumors are characterized by their rarity and insidious progression. They are often revealed in adulthood in the form of a pelvic mass. This study reports a new case of an intra-abdominal seminoma in a 57-year-old patient which presented with isolated left flank pain, which is an unusual symptom. Read More

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Safety of Minimizing Intensity of Follow-up on Active Surveillance for Clinical Stage I Testicular Germ Cell Tumors.

Eur Urol Open Sci 2022 Jun 27;40:46-53. Epub 2022 Apr 27.

Department of Surgery (Urology), Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

Background: We have recommended active surveillance as the preferred management option for clinical stage I (CSI) testicular germ cell tumors (GCTs) since 1980. Over time, the recommended intensity of surveillance has decreased; however, the impact on relapse detection has not been investigated.

Objective: To examine relapse rate, time to relapse, extent of disease, and burden of treatment at relapse across decreasing surveillance intensity over time. Read More

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Detection rates of urogenital cancers and benign pathology in men presenting with hematospermia.

Curr Urol 2022 Mar 28;16(1):44-49. Epub 2022 Jan 28.

Department of Urology, Institute of Andrology, University College London Hospitals NHS Trust, London, UK.

Background: Hematospermia, although often found to be a benign condition, can be an alarming sign. Consequently, patients can undergo multiple investigations with no current standardized pathway based on data from large series. The aim of this study was to evaluate the incidence of an underlying pathology and the value of diagnostic investigations performed in patients presenting with hematospermia. Read More

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Serum Levels of MicroRNA-371a-3p (M371) Can Predict Absence or Presence of Vital Disease in Residual Masses After Chemotherapy of Metastatic Seminoma.

Front Oncol 2022 6;12:889624. Epub 2022 May 6.

Faculty of Biology & Chemistry, University of Bremen, Bremen, Germany.

Background: Radiological evaluation of postchemotherapy residual masses of metastatic seminoma is characterized by poor diagnostic accuracy. Serum levels of microRNA-371a-3p (M371) involve high specificity and sensitivity for the primary diagnosis of seminoma. We evaluated if M371 levels can indicate the presence of vital disease in postchemotherapy residual masses in patients with metastatic seminoma. Read More

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Bilateral exudative retinal detachments and associated choroidal detachments in a patient on dapsone: a case report.

Int J Retina Vitreous 2022 May 20;8(1):31. Epub 2022 May 20.

Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, 1000 Wall St, Ann Arbor, MI, 48105, USA.

Background: Dapsone is a synthetic sulfonamide used to treat numerous dermatologic conditions. Ocular side effects have been rarely reported and include retinal necrosis, optic atrophy, and macular infarction. We report the first known case of bilateral choroidal effusions and exudative retinal detachments associated with dapsone use. Read More

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CDKN2AIP-induced cell senescence and apoptosis of testicular seminoma is associated with CARM1 and eIF4β.

Acta Biochim Biophys Sin (Shanghai) 2022 Apr 25. Epub 2022 Apr 25.

Department of Gynaecology and Obstetrics, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.

Testicular seminoma is a relatively rare tumor which is mostly detected in male population aged from 15 to old. Although several molecular biomarkers have been identified to be associated with testicular seminoma pathogenesis, the exact mechanism for testicular seminoma progression remains largely unknown. CDKN2AIP (CDKN2A interacting protein) has previously been identified as a tumor suppressor in multiple malignant diseases. Read More

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Genomic Profile in a Non-Seminoma Testicular Germ-Cell Tumor Cohort Reveals a Potential Biomarker of Sensitivity to Platinum-Based Therapy.

Cancers (Basel) 2022 Apr 20;14(9). Epub 2022 Apr 20.

Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, UNAM, Mexico City 14080, Mexico.

Despite having a favorable response to platinum-based chemotherapies, ~15% of Testicular Germ-Cell Tumor (TGCT) patients are platinum-resistant. Mortality rates among Latin American countries have remained constant over time, which makes the study of this population of particular interest. To gain insight into this phenomenon, we conducted whole-exome sequencing, microarray-based comparative genomic hybridization, and copy number analysis of 32 tumors from a Mexican cohort, of which 18 were platinum-sensitive and 14 were platinum-resistant. Read More

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How to classify, diagnose, treat and follow-up extragonadal germ cell tumors? A systematic review of available evidence.

World J Urol 2022 May 12. Epub 2022 May 12.

Department of Oncology, Hematology, BMT Plus Section Pneumology, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Purpose: To present the current evidence and the development of studies in recent years on the management of extragonadal germ cell tumors (EGCT).

Methods: A systematic literature search was conducted in Medline and the Cochrane Library. Studies within the search period (January 2010 to February 2021) that addressed the classification, diagnosis, prognosis, treatment, and follow-up of extragonadal tumors were included. Read More

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ACR Appropriateness Criteria® Staging and Surveillance of Testicular Cancer: 2021 Update.

J Am Coll Radiol 2022 05;19(5S):S194-S207

Specialty Chair, University of Alabama at Birmingham, Birmingham, Alabama; Chair, ACR Appropriateness Committee.

The staging and surveillance of testicular cancer is a complex topic, which integrates clinical, biochemical, and imaging components. The use of imaging for staging and surveillance of testicular cancer is individually tailored to each patient by considering tumor histology and prognosis. This document discusses the rationale for use of imaging by imaging modality during the initial staging of testicular seminoma and nonseminoma tumors and during the planned surveillance of stage IA and IB testicular cancer by histological subtype integrating clinical suspicion for disease recurrence in surveillance protocols. Read More

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Radiological clues for diagnosing intra-abdominal seminoma in undescended testis on computed tomography.

Radiol Case Rep 2022 Jun 26;17(6):2273-2276. Epub 2022 Apr 26.

Department of Radiology, Sanggye Paik Hospital Inje University College of Medicine, 1342 Dongil-ro, Nowon-gu, Seoul 01757, Repubilic of Korea.

We report a case of intra-abdominal seminoma in an undescended testis, focusing on the radiological clues for diagnosis on computed tomography. A 49-year-old man visited our hospital with a palpable abdominal mass and underwent abdominopelvic computed tomography. Computed tomography demonstrated an ovoid, mildly enhanced, well-defined mass measuring 21 × 16 × 9 cm in the small bowel mesentery mimicking a mass of mesenteric origin. Read More

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Metastatic Potential of Small Testicular Germ Cell Tumors: Implications for Surveillance of Small Testicular Masses.

Eur Urol Open Sci 2022 Jun 26;40:16-18. Epub 2022 Apr 26.

Department of Medical Oncology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.

Incidental detection of urogenital tumors has increased in recent decades owing to the greater use of ultrasonography and cross-sectional imaging. For patients with low-risk prostate cancer or small renal masses, active surveillance represents a valid treatment option. Similarly, for men with small testicular masses <10 mm, active surveillance has been discussed as an alternative to surgery, although little is known regarding the behavior of small testicular germ cell tumors (GCTs). Read More

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Primary seminoma of prostate in a patient with Klinefelter syndrome: A case report.

Medicine (Baltimore) 2022 Apr 29;101(17):e29117. Epub 2022 Apr 29.

Department of Urology, Capital Medical University Affiliated Beijing Shijitan Hospital, No. 10 Yangfangdian Road, Haidian District, Beijing, PR China.

Rationale: Klinefelter syndrome (KS) is a sex differentiation syndrome that occurs in men and is characterized by the 47XXY genotype. An association between KS and cancer has also been reported. The occurrence of seminoma of the prostate in KS has not been reported in the literature to date. Read More

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Management of stage II seminoma: a contemporary UK perspective.

Scott Med J 2022 May 4:369330221099619. Epub 2022 May 4.

Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Cancer Research UK Barts Centre, 4617Queen Mary University of London, London, UK.

Background And Aims: Testicular Germ Cell Tumours (TGCTs) are the commonest young adult male cancer, with excellent survival outcomes even with metastatic disease. Chemotherapy, radiotherapy, and surgery are international guideline-dictated standard of care (SOC) treatments for International Germ Cell Cancer Collaborative Group (IGCCCG) "good risk" TGCT, but are associated with significant toxicities. Therapy de-escalation aims to reduce treatment morbidity whilst preserving cure rates, and has been adopted by some centres for stage IIA/B seminoma. Read More

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An Introduction to the WHO 5 Edition 2022 Classification of Testicular tumours.

Histopathology 2022 May 3. Epub 2022 May 3.

Memorial Sloan-Kettering Cancer Center, Pathology, New York, NY, 10065, USA.

The 5 edition of the World Health Organisation 'blue book' was recently published and includes a comprehensive update on testicular tumours. This builds upon the work of the 4 edition, retaining its structure, and main nomenclature, including the use of the term 'germ cell neoplasia in situ' (GCNIS) for the preinvasive lesion of most germ cell tumours and division from those not derived from GCNIS. While there have been important developments in understanding the molecular underpinnings of testicular cancer, this updated classification paradigm and approach remains rooted in morphology. Read More

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Single-Cell RNA Sequencing of Metastatic Testicular Seminoma Reveals the Cellular and Molecular Characteristics of Metastatic Cell Lineage.

Front Oncol 2022 12;12:871489. Epub 2022 Apr 12.

Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, China.

Background: Testicular cancer is the most common solid malignancy in young men. Given the many histological classifications of testicular tumors, seminoma is one of the most treatable cancers. The survival rate in early-stage disease was more than 90%. Read More

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A comprehensive review of the "tigroid" background cytological concept: what, when, where and why?

Pathologica 2022 Apr;114(2):121-127

Department of Pathology, University Hospital La Paz, Madrid, Spain.

The concept of "tigroid" background is used in cytology to describe a peculiar smear background characterized by the presence of a relatively granular, reticulated material that was described as "foamy, lazy, tiger-striped or astrakhan". It was used to describe the background seen in smears obtained from seminoma. In addition to seminoma, we now know that it can be present in different tumours, mostly carcinomas and round cell sarcomas. Read More

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Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy.

Int J Radiat Oncol Biol Phys 2022 Apr 20. Epub 2022 Apr 20.

Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland; Università della Svizzera Italiana, Lugano, Switzerland; University of Bern, Bern, Switzerland; Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom.

Purpose: Radiation therapy is a possible treatment strategy for patients with testicular seminoma after orchiectomy in clinical stage I or II disease. Little is known about the outcome of patients who experience a relapse after radiation therapy.

Methods And Materials: Data from 61 patients who relapsed after adjuvant or curative radiation therapy from 17 centers in 11 countries were collected and retrospectively analyzed. Read More

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COVID-19 Infection Induce miR-371a-3p Upregulation Resulting in Influence on Male Fertility.

Biomedicines 2022 Apr 6;10(4). Epub 2022 Apr 6.

Clinic and Polyclinic for Urology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.

In December 2019, the first case of COVID-19 was reported and since then several groups have already published that the virus can be present in the testis. To study the influence of SARS-CoV-2 which cause a dysregulation of the androgen receptor (AR) level, thereby leading to fertility problems and inducing germ cell testicular changes in patients after the infection. Formalin-Fixed-Paraffin-Embedded (FFPE) testicular samples from patients who died with or as a result of COVID-19 ( = 32) with controls ( = 6), inflammatory changes ( = 9), seminoma with/without metastasis ( = 11) compared with healthy biopsy samples ( = 3) were analyzed and compared via qRT-PCR for the expression of miR-371a-3p. Read More

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RANKL regulates testicular cancer growth and Denosumab treatment has suppressive effects on GCNIS and advanced seminoma.

Br J Cancer 2022 Apr 13. Epub 2022 Apr 13.

Group of Skeletal, Mineral, and Gonadal Endocrinology, Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.

Background: Testicular germ cell tumours (TGCTs) have a high sensitivity to chemotherapy and a high cure rate, although with serious adverse effects. In the search for tumour suppressive drugs, the RANKL inhibitor Denosumab, used to treat osteoporosis, came up as a candidate since RANKL signalling was recently identified in the testis.

Methods: Expression of RANKL, RANK and OPG, and the effects of RANKL inhibition were investigated in human TGCTs, TGCT-derived cell-lines, and TGCT-xenograft models. Read More

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Testicular Germ Cell Tumours and Proprotein Convertases.

Cancers (Basel) 2022 Mar 23;14(7). Epub 2022 Mar 23.

Department of Cell Biology and Histology, Faculty of Pharmacy, University of the Basque Country (UPV/EHU), 01006 Vitoria-Gasteiz, Spain.

Testicular Germ Cell Tumours (TGCT) are widely considered a "curable cancer" due to their exceptionally high survival rate, even if it is reduced by many years after the diagnosis due to metastases and relapses. The most common therapeutic approach to TGCTs has not changed in the last 50 years despite its multiple long-term side effects, and because it is the most common malignancy in young Caucasian men, much research is needed to better the quality of life of the many survivors. Proprotein Convertases (PC) are nine serine proteases responsible for the maturation of inactive proproteins with many diverse functions. Read More

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Ultrasound Examination of Unilateral Seminoma in a Salernitano Stallion.

Animals (Basel) 2022 Apr 6;12(7). Epub 2022 Apr 6.

Faculty of Veterinary Medicine, University of Teramo, Piano d'Accio, 64100 Teramo, Italy.

An 18-year-old Salernitano stallion developed a progressive enlargement of the left testicle over eight months. An ultrasound evaluation was performed, along with a hormonal profile. A histopathological evaluation of the testis was performed after unilateral orchiectomy. Read More

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Testicular Germ Cell Tumor Composed of Seminoma and Teratoma Metastasizing as Choriocarcinoma to the Lung Successfully Treated With Salvage Chemotherapy and Bone-Marrow Transplant: A Case Report.

Cureus 2022 Mar 6;14(3):e22885. Epub 2022 Mar 6.

Hematology and Medical Oncology, HCA Houston Healthcare Kingwood Medical Center, Kingwood, USA.

A 25-year-old male presented to our hospital with two months of progressively worsening left arm swelling, intermittent left-sided chest pressure, and a painless right testicular mass. CT of the chest, abdomen, and pelvis revealed a large mediastinal mass, multiple lung nodules, and several large right testicular nodules. The patient underwent a CT-guided biopsy of his right lung nodule, followed by a radical right inguinal orchiectomy. Read More

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Differential expression of preferentially expressed antigen in melanoma (PRAME) in testicular germ cell tumors - A comparative study with SOX17.

Exp Mol Pathol 2022 Jun 4;126:104761. Epub 2022 Apr 4.

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:

The accurate identification of different components in testicular germ cell tumors (GCT) is essential for tailoring treatment and informing the clinical prognosis. PRAME (preferentially expressed antigen in melanoma), a member in the family of cancer testis antigens, plays critical roles in regulating pluripotency and suppressing somatic/germ cell differentiation in seminomas (SEM). To investigate the potential diagnostic value of PRAME in testicular GCT, here we comparatively examined the expression patterns of PRAME and SOX17 by immunohistochemistry in both pure and mixed GCT. Read More

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