6,359 results match your criteria Testicular Seminoma

Nomograms for Predicting Prognosis of Primary Mediastinal Seminoma: A Population-Based Study.

J Oncol 2021 19;2021:9048375. Epub 2021 May 19.

Department of Biotherapy, West China Hospital and State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China.

Objectives: Primary mediastinal seminoma (PMS) was an uncommon carcinoma, and the appropriate treatment remained controversial due to the low incidence. We aimed to investigate the demographics and tumor biological characteristics to determine the potential effective treatment and predict the prognosis.

Methods: Patients diagnosed with PMS were selected between 1975 and 2016 from Surveillance, Epidemiology, and End Results (SEER) database. Read More

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Primary mediastinal germ cell tumours with high prevalence of somatic malignancy: An experience from a single tertiary care oncology centre.

Ann Diagn Pathol 2021 May 26;53:151763. Epub 2021 May 26.

Department of Thoracic Surgery, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

Background: Primary mediastinal germ tumours (PMGCT) constitute, a mere 3-4% of all germ cell tumours (GCT). Although they account for approximately 16% of mediastinal tumours in adults and 19-25% in children as per western literature, there is hardly any large series on PMGCT reported from the Indian subcontinent.

Design: We have retrospectively analysed clinicopathological features of 98 cases of PMGCT diagnosed over 10 years (2010-2019) from a tertiary-care oncology centre. Read More

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Methylation gene is associated with overall survival in patients with seminoma.

Oncol Rep 2021 May 9;45(5). Epub 2021 Jun 9.

Affiliated Hospital of Putian University, Putian, Fujian 351100, P.R. China.

The aim of the present study was to explore and verify the potential mechanism of seminoma progression. Data on 132 RNA‑seq and 156 methylation sites from stage II/III and I seminoma specimens were downloaded from The Cancer Genome Atlas database. An initial filter of |fold‑change| >2 and false discovery rate <0. Read More

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Spermatocytic Tumor of Testis in a Young Male.

J Coll Physicians Surg Pak 2021 Jun;30(6):722-724

Department of Laboratory Medicine, Aga Khan University, Karachi, Pakistan.

Spermatocytic tumor is a rare germ cell tumor not related to germ cell neoplasia in situ, and derived from postpubertal-type germ cells. It was previously called "Spermatocytic Seminoma" due to false belief of its origin from germ cell neoplasia in situ. The tumor usually occurs in an older age group and orchidectomy is curative. Read More

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Diagnostic and prognostic impact of Cytokeratin 19 expression analysis in human tumors: A tissue microarray study of 13,172 tumors.

Hum Pathol 2021 Jun 5. Epub 2021 Jun 5.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

To evaluate cytokeratin 19 expression in normal and cancerous tissues, 15,977 samples from 122 tumor types and 608 samples of 76 normal tissue types were analyzed by immunohistochemistry. In normal tissues, CK19 expression occurred in epithelial cells of most glandular organs but was strictly limited to the basal cell layer of non-keratinizing squamous epithelium and absent in the skin. CK19 expression in ≥90% of cases was seen in 34% of the tumor entities including the adenocarcinomas of the pancreas (99. Read More

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Typical histological pattern of seminoma and its immunoreactivity: A diagnostic challenge.

Clin Case Rep 2021 May 24;9(5):e04091. Epub 2021 May 24.

Department of Pathology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh.

A 20-year-old man presented in the Department of Urology, with the complaint of left-sided lower abdominal lump for past 9 months. The patient denied of having any constitutional symptoms including weight loss. Read More

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Malignant Germ Cell Tumors and Their Precursor Gonadal Lesions in Patients with XY-DSD: A Case Series and Review of the Literature.

Int J Environ Res Public Health 2021 May 25;18(11). Epub 2021 May 25.

Department of Women's Health, Tübingen University Hospital, Calwerstr. 7, 72076 Tübingen, Germany.

The risk of gonadal germ cell tumors is increased over the lifetime of patients with XY-disorders of sex development (XY-DSD). The aim of this study was to evaluate clinical features and histopathological outcome after gonadectomy in patients with XY-DSD to assess the risk of malignant transformation to gonadal germ cell tumors. Thirty-five women treated for XY-DSD at our hospital between 2003 and 2020 were enrolled in this study. Read More

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Thymic Carcinomas and Second Malignancies: A Single-Center Review.

Cancers (Basel) 2021 May 19;13(10). Epub 2021 May 19.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Thymic carcinomas account for less than 0.01% of new cancer diagnoses annually and are more aggressive than thymomas. Autoimmune disorders have been associated with thymomas and only recently with thymic carcinomas. Read More

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Deficiency Causes Germ Cell Loss During Mouse Embryogenesis and Is Associated With Human Male Infertility.

Front Cell Dev Biol 2021 13;9:658966. Epub 2021 May 13.

Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.

Mutations affecting the germline can result in infertility or the generation of germ cell tumors (GCT), highlighting the need to identify and characterize the genes controlling germ cell development. The RNA-binding protein and E3 ubiquitin ligase TRIM71 is essential for embryogenesis, and its expression has been reported in GCT and adult mouse testes. To investigate the role of TRIM71 in mammalian germ cell embryonic development, we generated a germline-specific conditional knockout mouse (cKO) using the early primordial germ cell (PGC) marker as a Cre-recombinase driver. Read More

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Phase II trial of brentuximab vedotin in relapsed/refractory germ cell tumors.

Invest New Drugs 2021 May 24. Epub 2021 May 24.

Indiana University Simon Comprehensive Cancer Center, Indianapolis, IN, USA.

Background CD-30 is highly expressed in some patients with non-seminomatous germ-cell tumors. Brentuximab vedotin is an antibody-drug conjugate directed to CD-30. We report a phase 2 trial of brentuximab vedotin in patients with chemo-refractory GCT. Read More

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Mediastinal Germ Cell Tumors: A Review and Update on Pathologic, Clinical, and Molecular Features.

Adv Anat Pathol 2021 May 24. Epub 2021 May 24.

Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX Weill Medical College of Cornell University (WCMC), New York, NY.

Mediastinal germ cell tumors (MGCTs) are the most common extragonadal germ cell tumors (GCTs) and most often arise in the anterior mediastinum with a male predilection. MGCTs also have a predilection for patients with Klinefelter syndrome and possibly other genetic conditions. MGCTs, as GCTs at other extragonadal sites, are thought to arise from germ cells improperly retained during migration along the midline during embryogenesis. Read More

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A multilocular thymic cyst associated with mediastinal seminoma: evidence for its medullary epithelial origin highlighted by POU2F3-positive thymic tuft cells and concomitant myoid cell proliferation.

Virchows Arch 2021 May 24. Epub 2021 May 24.

Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.

Multilocular thymic cyst (MTC) and germ cell tumors are common diseases that impact the mediastinum. Correctly diagnosing these diseases can be difficult because several other conditions can mimic them. We report a male patient with MTC associated with mediastinal seminoma. Read More

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A Case of Primary Mediastinal Seminoma Associated With Testicular Microlithiasis and Liver Injury.

Cureus 2021 Apr 16;13(4):e14527. Epub 2021 Apr 16.

Oncology, Albert Einstein Medical Center, St. Barnabas Healthcare System, Bronx, USA.

Mediastinal seminomas are rare neoplasms that can be found incidentally in asymptomatic patients. However, a few cases may present in the emergency room with mild to severe respiratory and/or cardiovascular symptoms. This can occur when the tumor grows large enough to cause compression and obstruction of the various structures present in the thorax. Read More

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Treatment of clinical stage I non-seminoma.

Asian J Urol 2021 Apr 6;8(2):161-169. Epub 2021 Mar 6.

Department of Urology, University of Duesseldorf, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.

Germ cell cancers are the most common solid tumors among men between 15 and 40 years. Non-seminomatous germ cell tumors (NSGCTs) represent a unique and exclusive cohort of germ cell tumor patients. Non-seminoma can harbor different histologic components. Read More

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Molecular and epigenetic pathogenesis of germ cell tumors.

Asian J Urol 2021 Apr 30;8(2):144-154. Epub 2020 May 30.

Department of Urology, Urological Research Lab, Translational UroOncology, University Hospital Düsseldorf, Düsseldorf, Germany.

The development of germ cell tumors (GCTs) is a unique pathogenesis occurring at an early developmental stage during specification, migration or colonization of primordial germ cells (PGCs) in the genital ridge. Since driver mutations could not be identified so far, the involvement of the epigenetic machinery during the pathogenesis seems to play a crucial role. Currently, it is investigated whether epigenetic modifications occurring between the omnipotent two-cell stage and the pluripotent implanting PGCs might result in disturbances eventually leading to GCTs. Read More

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Spontaneous regression of an extragonadal seminomatous germ cell tumor.

Cancer Treat Res Commun 2021 Apr 24;28:100383. Epub 2021 Apr 24.

Departments of Internal Medicine, University of Colorado Anschutz Medical Campus 1635 Aurora Ct, Aurora, CO 80045 USA; Medical Oncology. Electronic address:

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Choroidal Metastasis Secondary to Testicular Mature Teratoma: A Case Report.

Ocul Oncol Pathol 2021 Mar 4;7(2):85-90. Epub 2021 Jan 4.

Sheffield Ocular Oncology Service, Department of Ophthalmology, Sheffield Teaching Hospitals, Sheffield, United Kingdom.

We report a case of a choroidal metastasis secondary to testicular mature teratoma, a subtype of non-seminoma germ cell tumours, in a young adult male. The choroidal metastasis was treated successfully with bleomycin, etoposide, and cisplatin chemotherapy without the need for adjuvant radiotherapy. This represents a rare case of mature teratoma metastasizing to the choroid and one of very few reported testicular germ cell tumours to achieve normal or near normal visual acuity with chemotherapy alone despite severe macular disease at presentation. Read More

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Clear identification of the rare solitary external iliac lymph node metastasis of testicular cancer by using indocyanine green fluorescence guidance.

IJU Case Rep 2021 May 24;4(3):163-166. Epub 2021 Feb 24.

Department of Urology The Jikei University School of Medicine Tokyo Japan.

Introduction: There are few reports on indocyanine green fluorescence-guided surgery in testis-related diseases.

Case Presentation: A 38-year-old man underwent orchiectomy for left testicular cancer. Pathological diagnosis was pT1 seminoma. Read More

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The m6A methyltransferase METTL3 regulates autophagy and sensitivity to cisplatin by targeting ATG5 in seminoma.

Transl Androl Urol 2021 Apr;10(4):1711-1722

Department of Urology, The Third Xiangya Hospital of Central South University, Changsha, China.

Background: Our previous work shows Autophagy enhanced resistance to cisplatin in seminoma. The expression of the N6-methyladenosine (m6A) methyltransferases METTL3 was significantly increased in the cisplatin-resistant TCam-2 cell line of seminoma. We aimed to investigate the role of m6A methylation in autophagy and the chemosensitivity of seminoma cells. Read More

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SSX C-Terminus is a Useful Diagnostic Biomarker for Spermatocytic Tumour.

Histopathology 2021 May 7. Epub 2021 May 7.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Aims: Spermatocytic tumour (ST) is a rare testicular germ cell neoplasm that can be challenging to diagnose and for which there are few confirmatory biomarkers. Like normal spermatogonia, STs are known to express SSX proteins. Recently, a novel SSX antibody directed against the C-terminus (SSX_CT) of SSX1, SSX2 and SSX4, has emerged as a reliable biomarker for these SSX proteins and synovial sarcoma. Read More

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Radiotherapy as a Single Modality in Primary Seminoma of the Prostate.

Cureus 2021 Apr 2;13(4):e14264. Epub 2021 Apr 2.

Medical Oncology, Grand River Regional Cancer Centre, Kitchener, CAN.

Extragonadal germ cell tumors (EGCTs) are uncommon, and those involving the prostate are rare. We report on a primary seminoma of the prostate in a 56-year-old male presenting with scrotal pain, urinary frequency and urgency, and erectile dysfunction. Digital rectal examination revealed a hard, markedly enlarged prostate projecting posteriorly into the rectum. Read More

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[Active surveillance for testicular tumors: adherence and safety.]

Arch Esp Urol 2021 May;74(4):397-403

Servicio de Urología. Hospital Alemán de Buenos Aires. Ciudad de Buenos Aires. Argentina.

Introduction: The active surveillance (AS) of testicular tumors (seminoma and non-seminoma) is the most frequent management option in the stage I disease. Relapses generally occurred within the first 3 years and <5% appear after this time cut-off point is fulfilled. Therefore, the adherence is one of the most important pillars in the AS protocol. Read More

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Dataset of testicular germ cell tumors (TGCT) risk associated with serum polychlorinated biphenyl (PCB) by age at diagnosis and histologic types.

Data Brief 2021 Jun 27;36:107014. Epub 2021 Mar 27.

School of Public Health, Brown University, Providence, RI 02903, USA.

In a population-based case control study of testicular germ cell tumors (TGCT), we reported a strong positive association between serum levels of Wolff's Group 1 (potentially estrogenic) polychlorinated biphenyl (PCBs) and risk of TGCT, and the observed associations were similar for both seminoma and non-seminoma. While the observed specific associations between TGCT and Wolff's Group 1 PCBs cannot be easily explained by bias or confounding, a question can still be asked, that is, could the relationship between PCBs and TGCT differ by age at diagnosis? PCBs tend to bioaccumulate, with more heavily chlorinated PCB congeners tending to have longer half-lives. Half-lives of PCB congeners were reported ranging from 4. Read More

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Histological Features of Sporadic and Familial Testicular Germ Cell Tumors Compared and Analysis of Age-Related Changes of Histology.

Cancers (Basel) 2021 Apr 1;13(7). Epub 2021 Apr 1.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA.

This study aimed to compare histological features of familial and sporadic testicular germ cell tumors (TGCTs) and surrounding parenchyma, since discriminating features might be etiologically relevant and clinically useful. The study of parenchyma was prompted by reports claiming a higher prevalence of testicular microlithiasis in familial cases. Histological features of TGCTs and surrounding parenchyma of 296 sporadic and 305 familial cases were compared. Read More

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Paraneoplastic Neurological Syndromes and Beyond Emerging With the Introduction of Immune Checkpoint Inhibitor Cancer Immunotherapy.

Front Neurol 2021 9;12:642800. Epub 2021 Apr 9.

Departments of Neurology and Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, United States.

Paraneoplastic neurological syndromes are more commonly seen with malignancies such as small cell lung cancer, thymoma, gynecological malignancies, and breast cancer as well as seminoma. With the introduction of immune checkpoint inhibitor (ICI) cancer immunotherapy we see an increase of autoimmune neurological complications in patients with malignancies not traditionally associated with paraneoplastic neurological syndromes, such as melanoma and renal cell carcinoma. Immune checkpoint inhibitors enhance antitumor immune responses resulting often in immune-related adverse effects that can affect any organ, including the central and peripheral nervous system, neuromuscular junction and muscle. Read More

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Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.

Adv Anat Pathol 2021 Apr 12. Epub 2021 Apr 12.

Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.

Testicular tumors are incredibly diverse and one of the most challenging areas in surgical pathology. Because of the rarity and overlapping features with numerous entities occurring in the testis and paratestis, these tumors pose a diagnostic challenge even to the most experienced general pathologists. In 2016, the latest "World Health Organization (WHO) classification of testicular tumors" was released, which incorporated several updates to the previous 2004 classification system. Read More

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Clinical characteristics and management of Turner patients with a small supernumerary marker chromosome.

Gynecol Endocrinol 2021 Apr 19:1-5. Epub 2021 Apr 19.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Objective: To summarize the clinical characteristics of Turner syndrome (TS) with a small supernumerary marker chromosome (sSMC) and discuss the clinical significance and management of TS patients with sSMC.

Methods: A retrospective analysis was conducted on the clinical data of 244 patients with disorders of sexual development admitted to Peking Union Medical College Hospital from February 1984 to July 2020.

Results: Among the 244 patients with a disorder of sexual development, 69 cases of TS were identified in which 13 patients had sSMC. Read More

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Mismatch repair deficiency occurs very rarely in seminomas.

Transl Androl Urol 2021 Mar;10(3):1048-1055

Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: Dense tumor-associated lymphocyte infiltration is linked to mismatch repair (MMR) deficiency in colorectal and endometrial cancer. MMR deficiency is of high clinical importance as MMR deficient cancers tend to react favorably to treatment with immune checkpoint inhibitors. Strong lymphocytic infiltration is a morphological hallmark of seminomas. Read More

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Primary Testicular Neuroendocrine Tumor Coexisting With Seminoma Sharing Germ Cell Origin.

Int J Surg Pathol 2021 Apr 13:10668969211008980. Epub 2021 Apr 13.

118084Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.

A 40-year-old, male, Japanese patient presented with the complaint of painless, right testicular swelling. Tumor markers for testicular cancer were normal. He underwent radical orchiectomy with the clinical diagnosis of stage I seminoma. Read More

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The Potential of Artificial Intelligence to Detect Lymphovascular Invasion in Testicular Cancer.

Cancers (Basel) 2021 Mar 16;13(6). Epub 2021 Mar 16.

Department of Cellular Pathology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU, UK.

Testicular cancer is the most common cancer in men aged from 15 to 34 years. Lymphovascular invasion refers to the presence of tumours within endothelial-lined lymphatic or vascular channels, and has been shown to have prognostic significance in testicular germ cell tumours. In non-seminomatous tumours, lymphovascular invasion is the most powerful prognostic factor for stage 1 disease. Read More

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