6,181 results match your criteria Testicular Seminoma


Evaluating the Effect of Cryptorchidism on Clinical Stage of Testicular Seminoma.

Cancer Manag Res 2020 23;12:4883-4888. Epub 2020 Jun 23.

Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.

Objective: To study the effect of cryptorchidism on clinical stage (CS) of testicular seminoma (TS).

Patients And Methods: In the Surveillance Epidemiology and End Results (SEER) database (2006-2016), people with TS were enrolled in our research. Multivariable logistic regression models were constructed to compare the impact of cryptorchidism on CS. Read More

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http://dx.doi.org/10.2147/CMAR.S236618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320749PMC

Testicular seminoma with large direct iliac nodal metastasis: unusual presentation.

BMJ Case Rep 2020 Jun 30;13(6). Epub 2020 Jun 30.

Urology and Renal Transplant, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

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http://dx.doi.org/10.1136/bcr-2020-236702DOI Listing

[A Case of Metachronous Testicular Tumor Developing Twenty Years after Treatment of Retroperitoneal Extragonadal Germ Cell Tumor].

Hinyokika Kiyo 2020 Jun;66(6):171-176

The Department of Urology, Aichi Medical University School of Medicine.

A 49-year-old male visited our department of gastroenterology with chief complaints of blackish feces and ill complexion in February 1997. Computed tomography (CT) revealed a right retroperitoneal tumor, which was removed the same month. Histopathological examination showed teratoma and yolk sac tumor. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_66_6_171DOI Listing

Meta-Analysis of Gene Expressions in Testicular Germ Cell Tumor Histologies.

Int J Mol Sci 2020 Jun 24;21(12). Epub 2020 Jun 24.

Facultad de Ciencias Informaticas, Universidad Tecnica de Manabi, Portoviejo 130105, Ecuador.

There is no consensus as to how a precursor lesion, germ cell neoplasia in situ (GCNIS), develops into the histologic types of testicular germ cell tumor type II (TGCT). The present meta-analysis examined RNA expressions of 24 candidate genes in three datasets. They included 203 samples of normal testis (NT) and histologic types of TGCT. Read More

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http://dx.doi.org/10.3390/ijms21124487DOI Listing

Investigation of EGFR/pi3k/Akt signaling pathway in seminomas.

Biotech Histochem 2020 Jun 29:1-13. Epub 2020 Jun 29.

Department of Clinical Biochemistry, Clinical Hospital (UBA), C.A.B.A., INFIBIOC , Córdoba, Argentina.

Activation of the receptor for epidermal growth factor (EGFR) in some testicular tumors activates several signaling pathways. Some components of these pathways are phosphorylated or mutated in testicular germ tumors (TCGT), including EGFR, Kirstein ras oncogen (KRAS) and cell surface protein of the germ cell (KIT). The latter two activate RAF ⁄MEK⁄ERK and PI3 K⁄AKT, and interconnect with the EGFR/pI3 k/Akt pathway. Read More

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http://dx.doi.org/10.1080/10520295.2020.1776393DOI Listing

Discrepancy in pathology reports upon second review of radical orchiectomy specimens for testicular germ cell tumors.

Can Urol Assoc J 2020 Jun 16. Epub 2020 Jun 16.

Division of Urology, Department of Surgery, Princess Margaret Cancer Centre, Toronto, ON, Canada.

Introduction: We sought to evaluate the discrepancies between primary pathology report and second pathology review of radical orchiectomy (RO) specimens.

Methods: A retrospective review was performed of RO specimens from the Ontario Cancer Registry. All cases required both a primary pathology report and a second pathology review from another institution. Read More

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http://dx.doi.org/10.5489/cuaj.6481DOI Listing

Controversies in the management of clinical stage 1 testis cancer.

Can Urol Assoc J 2020 Jun 9. Epub 2020 Jun 9.

Division of Urology, Department of Surgery, Princess Margaret Cancer Centre, Toronto, ON, Canada.

In November 2018, The Canadian Testis Cancer Workshop was convened. The two-day workshop involved urologists, medical and radiation oncologists, pathologists, radiologists, physician's assistants, residents and fellows, nurses, patients and patient advocacy groups. One of the goals of the workshop was to discuss the challenging areas of testis cancer care where guidelines may not be specific. Read More

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http://dx.doi.org/10.5489/cuaj.6722DOI Listing

Oncologic outcomes of pre-malignant and invasive germ cell tumors in patients with differences in sex development - A systematic review.

J Pediatr Urol 2020 May 23. Epub 2020 May 23.

Department of Urology, University of Kentucky, Lexington, KY, USA. Electronic address:

Objective: To describe the rates of GCNIS-free and GCT-free pathology based on age at gonadal surgery and to describe long-term oncologic outcomes in patients with DSD who have GCNIS or GCT at the time of gonadal surgery.

Study Design: A systematic review was conducted using MEDLINE to identify patients with DSD who underwent gonadal surgery. DSD diagnoses were stratified based on malignancy risk. Read More

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http://dx.doi.org/10.1016/j.jpurol.2020.05.002DOI Listing

HNF1β is a sensitive and specific novel marker for yolk sac tumor: a tissue microarray analysis of 601 testicular germ cell tumors.

Mod Pathol 2020 Jun 19. Epub 2020 Jun 19.

Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.

Hepatocyte Nuclear Factor 1 beta (HNF1β) is a transcription factor which plays an important role during early organogenesis, especially of the pancreato-biliary and urogenital tract. Furthermore, HNF1β is an established marker in the differential diagnosis of ovarian cancer and shows a distinct nuclear expression in the clear cell carcinoma subtype. Recently, it has been described in yolk sac tumor, which represents a common component in many non-seminomatous germ cell tumors. Read More

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http://dx.doi.org/10.1038/s41379-020-0597-xDOI Listing

Current insights into interethnic variability in testicular cancers: Population pharmacogenetics, clinical trials, genetic basis of chemotherapy-induced toxicities and molecular signal transduction.

Curr Top Med Chem 2020 Jun 18. Epub 2020 Jun 18.

SVKM's Dr. Bhanuben Nanavati College of Pharmacy, University of Mumbai, V. L. Mehta Road, Vile Parle (West), Mumbai - 400 056. India.

Testicular cancer is an aggressive malignancy with a rising incidence rate across the globe. Testicular germ cell tumors are the most common diagnoses, and surgical removal of the testes is often a radical necessity along with chemotherapy and radiotherapy. While seminomas are receptive to radiotherapy as well as chemotherapy, non-seminomatous germ cell tumors respond to chemotherapy only. Read More

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http://dx.doi.org/10.2174/1568026620666200618112205DOI Listing

Bcl2-Associated X (BAX) Knockout in Mice Resulted in Persistence of Neonatal Testicular Germ Cells (Gonocytes).

Sex Dev 2020 Jun 16. Epub 2020 Jun 16.

During early testicular development, neonatal gonocytes transform into spermatogonial stem cells (SSC), and any untransformed gonocytes are thought to undergo apoptosis. In human cryptorchidism, persisting gonocytes may lead to seminoma. Using Bcl2-associated X knockout (BAXKO) mice, we investigated apoptosis in gonocyte development during mouse minipuberty. Read More

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http://dx.doi.org/10.1159/000508567DOI Listing

An Unusual Case of Metastatic Basal Cell Carcinoma of the Prostate: A Case Report and Literature Review.

Front Oncol 2020 27;10:859. Epub 2020 May 27.

Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin, China.

Primary basal cell carcinoma (BCC) is a rare prostate cancer. Currently, a standard treatment regime for BCC of the prostate is lacking and most patients have a poor prognosis. We reported on a patient with BCC of the prostate whose cancer metastasized after undergoing a radical prostatectomy and whose prognosis improved after treatment with etoposide. Read More

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http://dx.doi.org/10.3389/fonc.2020.00859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267053PMC

A Systematic Review on Guidelines and Recommendations for Urology Standard of Care During the COVID-19 Pandemic.

Eur Urol Focus 2020 Jun 5. Epub 2020 Jun 5.

S.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.

Context: The first case of the new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), was identified in Wuhan, China, in late 2019. Since then, the coronavirus disease 2019 (COVID-19) outbreak was reclassified as a pandemic, and health systems around the world have faced an unprecedented challenge.

Objective: To summarize guidelines and recommendations on the urology standard of care during the COVID-19 pandemic. Read More

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http://dx.doi.org/10.1016/j.euf.2020.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274599PMC

The metastatic potential of seminomatous germ cell tumours is associated with a specific microRNA pattern.

Andrology 2020 Jun 12. Epub 2020 Jun 12.

Department of Urology and Pediatric Urology, Saarland University, Homburg, Saar, Germany.

Background: Seminomatous germ cell tumours (SGCT) are the most frequent malignancy in young men. Reliable prognostic biomarkers for the prediction of metastasis at diagnosis and the risk of relapse in clinical stage I (CSI) are lacking. Adjuvant therapies carry a risk of overtreatment, whereas salvage therapies have a risk of high toxicities. Read More

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http://dx.doi.org/10.1111/andr.12838DOI Listing

Does primary tumor localization has prognostic importance in seminoma patients?: Turkish Oncology Group Study.

J BUON 2020 Mar-Apr;25(2):1130-1135

Health Sciences University, Gülhane Training and Research Hospital, Department of Medical Oncology, Ankara, Turkey.

Purpose: The purpose of this study was to determine whether primary tumor localization may be a risk factor for relapse and survival in seminomatous germ cell tumors (GCT) patients.

Methods: In our study, 612 seminomatous GCT patients diagnosed in 22 centers between 01.01. Read More

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Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development.

Eur J Transl Myol 2020 Apr 1;30(1):8737. Epub 2020 Apr 1.

School of Biological Sciences, University of Reading, UK.

Numerous approaches are being developed to promote post-natal muscle growth based on attenuating Myostatin/Activin signalling for clinical uses such as the treatment neuromuscular diseases, cancer cachexia and sarcopenia. However there have been concerns about the effects of inhibiting Activin on tissues other than skeletal muscle. We intraperitoneally injected mice with the Activin ligand trap, sActRIIB, in young, adult and a progeric mouse model. Read More

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http://dx.doi.org/10.4081/ejtm.2019.8737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254437PMC

Evidence that activin A directly modulates early human male germline differentiation status.

Reproduction 2020 Jul;160(1):141-154

Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Victoria, Australia.

Disrupted fetal germline development underpins testicular germ cell neoplasia, which is increasing worldwide. The complex signaling milieu during normal testis development includes TGFβ superfamily ligands; this study tests the hypothesis that, activin A, a TGFβ superfamily member, can influence gonocyte development. The human seminoma-derived cell line, TCam-2, a model of fetal gonocytes, was cultured with activin A (1. Read More

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http://dx.doi.org/10.1530/REP-20-0095DOI Listing

[A Case of Primary Mediastinal Seminoma Showing Local Increase in Residual Tumor after Chemotherapy].

Hinyokika Kiyo 2020 May;66(5):153-155

The Department of Urology, Faculty of Medicine, University of Tsukuba.

A 19-year-old man with abnormal findings on his chest X ray was referred to our hospital. A chest computed tomography scan revealed a 57 mm mass in the anterior mediastinum, and percutaneous needle biopsy was performed. Histopathological diagnosis was pure seminoma. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_66_5_153DOI Listing

Luteinizing Hormone Receptor Is Expressed in Testicular Germ Cell Tumors: Possible Implications for Tumor Growth and Prognosis.

Cancers (Basel) 2020 May 26;12(6). Epub 2020 May 26.

Group of Skeletal, Mineral and Gonadal Endocrinology, Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.

Luteinizing hormone/choriogonadotropin receptor (LHCGR) regulates gonadal testosterone production and recent studies have suggested a growth-regulatory role in somatic cancers. Here, we established that LHCGR is expressed in a fraction of seminoma cells and germ cell neoplasia in situ (GCNIS), and the seminoma-derived cell line TCam2 released LHCGR into the medium. LH treatment induced proliferation of TCam2 cells in vitro, while hCG treatment induced a non-significant 51% increase in volume of tumors formed in a TCam2 xenograft model. Read More

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http://dx.doi.org/10.3390/cancers12061358DOI Listing

Patterns of relapse and treatment outcome after active surveillance or adjuvant carboplatin for stage I seminoma: a retrospective study of the Spanish Germ Cell Cancer Group.

Clin Transl Oncol 2020 May 27. Epub 2020 May 27.

Institut Catalá d'Oncologia Hospitalet, IDIBELL, University of Barcelona, Barcelona, Spain.

Purpose: Active surveillance (AS) and adjuvant chemotherapy (AC) with carboplatin are valid alternatives for managing stage I seminoma, and most relapses can be cured with cisplatin-based chemotherapy. However, some reports suggest that AC may modify the classical pattern of recurrences.

Methods: We analyzed all relapses observed in a series of 879 patients with stage I seminoma included in 4 consecutive studies of the Spanish Germ Cell Cancer Group. Read More

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http://dx.doi.org/10.1007/s12094-020-02393-9DOI Listing

Semen quality from patients affected by seminomatous and non-seminomatous testicular tumor.

Int Braz J Urol 2020 May 10;46. Epub 2020 May 10.

Departamento de Cirurgia, Divisão de Urologia, Universidade Federal de São Paulo - UNIFESP São Paulo, SP, Brasil.

Testicular cancer is considered a rare disease affecting approximately 1% to 2% of the male population. This neoplasm has a cure rate of over 95%; as a result, a major concern is the future of fertility of carriers from this disease. There are several histological subtypes of testicular tumors; however, the Testicular Germ Cell Tumors (TGCTs), comprising both seminoma and non-seminoma tumors, are considered the main subtypes of testicular neoplasms. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2021.99.01DOI Listing

Solid and Hematologic Neoplasms After Testicular Cancer: A US Population-Based Study of 24 900 Survivors.

JNCI Cancer Spectr 2020 Jun 17;4(3):pkaa017. Epub 2020 Mar 17.

University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA.

Background: No large US population-based study focusing on recent decades, to our knowledge, has comprehensively examined risks of second malignant solid and hematological neoplasms (solid-SMN and heme-SMN) after testicular cancer (TC), taking into account initial therapy and histological type.

Methods: Standardized incidence ratios (SIR) vs the general population and 95% confidence intervals (CI) for solid-SMN and heme-SMN were calculated for 24 900 TC survivors (TCS) reported to the National Cancer Institute's Surveillance, Epidemiology, and End Results registries (1973-2014). All statistical tests were two-sided. Read More

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http://dx.doi.org/10.1093/jncics/pkaa017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236780PMC

Multiparametric ultrasonographic analysis of testicular tumors: a single-center experience in a collective of 49 patients.

Scand J Urol 2020 Jun 25;54(3):241-247. Epub 2020 May 25.

Department of Radiology, Ludwig-Maximilians-University Munich - Grosshadern Campus, Munich, Germany.

The aim of the present retrospective single-center study is to evaluate the diagnostic performance of multiparametric ultrasonography for characterizing testicular tumors. Forty-nine patients with testicular tumors, 36 of malignant vs 13 of benign entity, were included in this retrospective single-center study on whom multiparametric sonography, encompassing native B-mode, Color Doppler, contrast-enhanced ultrasound (CEUS) and elastography, was performed between 2011-2018. In 48 of 49 patients, findings from multiparametric analysis were correlated with histopathological results. Read More

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http://dx.doi.org/10.1080/21681805.2020.1765863DOI Listing

Outcomes following surgery for primary mediastinal nonseminomatous germ cell tumors in the cisplatin era.

J Thorac Cardiovasc Surg 2020 Apr 22. Epub 2020 Apr 22.

Division of Medical Oncology, Department of Medicine, Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Ind.

Objective: Treatment of primary mediastinal nonseminomatous germ cell tumors involves cisplatin-based chemotherapy followed by surgery to remove residual disease. We undertook a study to determine short and long-term outcomes.

Methods: A retrospective analysis of patients with primary mediastinal nonseminomatous germ cell tumors who underwent surgery at our institution from 1982 to 2017 was performed. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2020.01.118DOI Listing

Fine needle aspiration of mediastinal germ cell tumors.

Semin Diagn Pathol 2020 May 13. Epub 2020 May 13.

Department of Pathology and Laboratory Medicine University of Florida-Jacksonville, Jacksonville, FL.

Germ cell tumors in the mediastinum are rare and often occur in young patients but may occur in older patients. Seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma and teratoma have distinct morphologic features with high grade nuclei. They are the primary diagnostic consideration in young males but may be lower on the list in older patients, where they may be misdiagnosed as carcinomas. Read More

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http://dx.doi.org/10.1053/j.semdp.2020.04.008DOI Listing

'Snail factors in testicular germ cell tumours and their regulation by the BMP4 signalling pathway'.

Andrology 2020 May 22. Epub 2020 May 22.

Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Victoria, Australia.

Background: Snail transcription factors mediate key cellular transitions in many developmental processes, including spermatogenesis, and their production can be regulated by TGF-β superfamily signalling. SNAI1 and SNAI2 support many cancers of epithelial origin. Their functional relevance and potential regulation by TGF-β superfamily ligands in germ cell neoplasia are unknown. Read More

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http://dx.doi.org/10.1111/andr.12823DOI Listing

Testicular cancer in Hispanics: incidence of subtypes over time according to neighborhood sociodemographic factors in California.

Cancer Causes Control 2020 Aug 21;31(8):713-721. Epub 2020 May 21.

Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.

Purpose: Hispanic men in the USA experience the second-highest incidence rate of testicular germ cell tumors (TGCTs), behind non-Hispanic (NH) White men, and have experienced steep increases in TGCT in recent decades. It is unknown whether increases in incidence differ according to neighborhood sociodemographic factors.

Methods: We conducted a population-based study of n = 3759 Hispanic and n = 8469 NH White men (n = 12,228 total) diagnosed with TGCT in California during the three most recent pericensal periods. Read More

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http://dx.doi.org/10.1007/s10552-020-01311-2DOI Listing

Targeting EpCAM by a Bispecific Trifunctional Antibody Exerts Profound Cytotoxic Efficacy in Germ Cell Tumor Cell Lines.

Cancers (Basel) 2020 May 19;12(5). Epub 2020 May 19.

Department of Pediatric Hematology and Oncology, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany.

Outcome in high-risk patients with refractory or relapsed germ cell tumours (GCT) remains poor. Novel strategies enhancing therapeutic efficacy whilst limiting therapeutic burden are warranted, yet immunotherapy approaches geared towards activating endogenous antitumor responses have not been successful thus far. Redirection of cytotoxic effector cells by bispecific antibodies represents a promising approach in this setting. Read More

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http://dx.doi.org/10.3390/cancers12051279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281168PMC

Mediastinal seminoma mimicking invasive thymoma on F-FDG PET/CT.

Authors:
Huipan Liu Yue Chen

J Nucl Cardiol 2020 May 6. Epub 2020 May 6.

Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University/Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, No. 25 TaiPing St., Jiangyang District, Luzhou, 646000, Sichuan, People's Republic of China.

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http://dx.doi.org/10.1007/s12350-020-02127-yDOI Listing

Testicular Seminoma Presenting with Bilateral Blindness: Looking Beyond the Eye.

Cureus 2020 Apr 4;12(4):e7534. Epub 2020 Apr 4.

Pulmonary and Critical Care, Truman Medical Center, University of Missouri-Kansas City School of Medicine, Kansas City, USA.

Cancer-associated retinopathy (CAR) is a rare cause of vision loss that was first reported in 1976. It is reported that the retinopathy associated with cancer occurs due to antibodies against the tumor antigens that cross-react with retinal cell layers. We present the case of a young male who came to the emergency department with sudden onset of bilateral vision loss. Read More

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http://dx.doi.org/10.7759/cureus.7534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198102PMC

Human chorionic gonadotropin-positive seminoma patients: A registry compiled by the global germ cell tumor collaborative group (G3).

Eur J Cancer 2020 Jun 29;132:127-135. Epub 2020 Apr 29.

Department of Oncology, Hematology and Bone Marrow Transplantation with Division of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: The prognostic role of human chorionic gonadotropin (hCG) and lactate dehydrogenase (LDH) serum levels in seminoma patients remains uncertain. This observational study evaluates the prognostic impact of tumour marker levels, and other clinicopathological findings, in hCG-positive seminoma patients.

Methods: Seminoma patients with serum hCG levels above normal at first diagnosis were eligible for recruitment. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.03.022DOI Listing

CD34 Positive Tubular Basement Membrane in Testicular Germ Cell Tumors: A Potential Staging Pitfall.

Histopathology 2020 May 1. Epub 2020 May 1.

Department of Pathology, VCU School of Medicine, Richmond, VA, 23226, USA.

Staging of testicular germ cell tumours is essential for treatment planning and prognosis[1]. Lymphovascular invasion (LVI) is one key parameter that establishes pT2 in pathologic staging and Prognostic Stage Group IB for both seminoma and mixed germ cell tumours otherwise limited to the testis [1]. While current practice guidelines [2] consider surveillance preferred for Stage I pure seminomas given the high rate of cure by orchiectomy alone, single agent carboplatin or radiotherapy remain considerations. Read More

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http://dx.doi.org/10.1111/his.14131DOI Listing

HMGA1-Regulating microRNAs Let-7a and miR-26a are Downregulated in Human Seminomas.

Int J Mol Sci 2020 Apr 24;21(8). Epub 2020 Apr 24.

Department of Psychology, University of Campania "L. Vanvitelli", 81100 Caserta, Italy.

Background: Recent studies have underlined HMGA protein's key role in the onset of testicular germ cell tumors, where HMGA1 is differently expressed with respect to the state of differentiation, suggesting its fine regulation as master regulator in testicular tumorigenesis. Several studies have highlighted that the transcript is strictly regulated by a set of inhibitory microRNAs. Thus, the aim of this study is to test whether HMGA1 overexpression in human seminomas may be induced by the deregulation of miR-26a and Let-7a-two -targeting microRNAs. Read More

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http://dx.doi.org/10.3390/ijms21083014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215726PMC

Supraclavicular left neck mass: an unusual presentation of metastatic testicular cancer in two older men.

BMJ Case Rep 2020 Apr 22;13(4). Epub 2020 Apr 22.

Department of Radiology, Eastbourne District General Hospital, Brighton, UK.

Two male patients, aged 55 and 75 years, were referred to the ENT and haematology team respectively, with an asymptomatic left supraclavicular neck mass. Investigations revealed metastatic primary testicular seminoma. CT contrast study of the thorax, abdomen and pelvis demonstrated an additional left para-aortic nodal mass in both cases. Read More

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http://dx.doi.org/10.1136/bcr-2019-233368DOI Listing

Testicular Carcinoid Tumor in a Patient With Contralateral Classic Seminoma.

Urology 2020 Jul 16;141:e32-e34. Epub 2020 Apr 16.

Institute of Urology, University of Southern California, Los Angeles, CA. Electronic address:

Testicular neuroendocrine tumors, commonly called carcinoid, are extremely rare and account for less than 1% of all testicular neoplasms. The most common type is primary carcinoid followed by testicular metastasis from another primary and rarely carcinoid within a testicular teratoma. To date, less than 25 cases of carcinoid associated teratomas have been reported in the literature. Read More

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http://dx.doi.org/10.1016/j.urology.2020.04.011DOI Listing
July 2020
2.188 Impact Factor

Prognostic Potential of the Expression of Podoplanin (D2-40) Within Cells of Squamous Cell Carcinoma of the Larynx and Hypopharynx.

World J Oncol 2020 Apr 29;11(2):65-71. Epub 2020 Mar 29.

Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital of Wuerzburg, Josef-Schneider-Str. 2, D-97080 Wuerzburg, Germany.

Background: Podoplanin (D2-20) stains immunohistochemically lymphatic vessels, regular mesothelium and tumor cells of different tumors, e.g. malignant mesothelioma or seminoma. Read More

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http://dx.doi.org/10.14740/wjon1259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141162PMC

The Clinical Significance of Seminoma Component in Testicular Mixed Germ Cell Tumour.

Urol Int 2020 2;104(5-6):489-496. Epub 2020 Apr 2.

Department of Urology, University of Health Sciences, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.

Background: The aim of this study was to examine clinical/pathological characteristics, prognosis and tendency to metastasis of mixed germ cell tumours (MGCTs) that contain a seminoma component.

Methods: A total of 111 MGCT cases between 2008 and 2018 were retrospectively enrolled. The patients were divided into 2 groups according to the absence (group 1) or presence (group 2) of seminoma component in MGCTs. Read More

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http://dx.doi.org/10.1159/000506780DOI Listing

Non-Coding microRNAs as Novel Potential Tumor Markers in Testicular Cancer.

Cancers (Basel) 2020 Mar 22;12(3). Epub 2020 Mar 22.

Research Unit of Non-Coding RNAs and Genome Editing in Cancers, Medical University of Graz, 8010 Graz, Austria.

Testicular cancer is an important disease with increasing incidence and a high burden of morbidity and mortality in young men worldwide. Histological examination of the testicular tissue after orchiectomy plays an important role alongside patient history, imaging, clinical presentation and laboratory parameters. Surgical procedures and chemotherapeutic treatment provide a high chance of cure in early stages, though some patients in advanced stages belonging to a poor risk group experience cancer-related death. Read More

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http://dx.doi.org/10.3390/cancers12030749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140096PMC

[Clinicopathologic features of testicular seminoma with syncytiotrophoblastic cells: Analysis of 3 cases and review of the literature].

Zhonghua Nan Ke Xue 2019 Jul;25(7):642-646

Department of Pathology, General Hospital of Eastern Theater Command, Nanjing, Jiangsu 210002, China.

Objective: To investigate the clinical and histopathologic features of testicular seminoma with syncytoplasmic trophoblastic components.

Methods: Using light microscopic staining, we analyzed the clinical and histopathologic characteristics, diagnosis, differential diagnosis and prognosis of 3 cases of testicular seminoma with syncytoplasmic trophoblastic components, and reviewed the relevant literature.

Results: All the 3 cases were typical seminoma with syncytiotrophoblastic giant cells. Read More

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Identification of sumoylated targets in proliferating mouse spermatogonia and human testicular seminomas.

Asian J Androl 2020 Mar 27. Epub 2020 Mar 27.

Department of Biology, Stern College, Yeshiva University, New York, NY 10016, USA.

Spermatogenesis is regulated by a complex network of posttranslation modifications. Sumoylation (a modification by small ubiquitin-like modifiers, or SUMO proteins) was identified as an important cellular event in different cell types. SUMO proteins are highly expressed in the testis, and their role during spermatogenesis has begun to be elucidated. Read More

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http://dx.doi.org/10.4103/aja.aja_11_20DOI Listing

Paraneoplastic tumefactive demyelination in a 47-year-old man with underlying seminoma.

Mult Scler Relat Disord 2020 Jul 16;42:102060. Epub 2020 Mar 16.

Neurology department, GZA Sint-Augustinus Hospital, Oosterveldlaan 24, 2610 Antwerp, Belgium.

Background: Tumefactive demyelination presents as an aggressive, fast progressive focal demyelinating lesion in the central nervous system, with often devastating clinical outcome if not acutely treated. Correct and early treatment is threatened by its real diagnostic challenge.

Case Report: We describe a 47-year-old man with tumefactive demyelination and testicular seminoma. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102060DOI Listing

Management of Giant Seminoma in an Undescended Testis: a Case Report.

Indian J Surg Oncol 2020 Mar 17;11(1):159-161. Epub 2019 Aug 17.

SMS Medical College & Attached Hospitals, Jaipur, Rajasthan India.

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http://dx.doi.org/10.1007/s13193-019-00967-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064672PMC

Report From the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers: IV: Current and Future Utilization of Molecular-Genetic Tests for Testicular Germ Cell Tumors.

Am J Surg Pathol 2020 Jul;44(7):e66-e79

Pathology, Indiana University School of Medicine, Indianapolis, IN.

The International Society of Urological Pathology (ISUP) organized a Consultation Conference in March 2019 dealing with applications of molecular pathology in Urogenital Pathology, including testicular tumors (with a focus on germ cell tumors [GCTs]), preceded by a survey among its members to get insight into current practices in testicular germ cell tumor (TGCT) diagnostics and adoption of the ISUP immunohistochemical guidelines published in 2014. On the basis of the premeeting survey, the most commonly used immunomarker panel includes OCT3/4, placental alkaline phosphate, D2-40, SALL4, CD117, and CD30 for GCTs and the documentation of germ cell neoplasia in situ (GCNIS). Molecular testing, specifically 12p copy gain, is informative to distinguish non-GCNIS versus GCNIS related GCTs, and establishing germ cell origin of tumors both in the context of primary and metastatic lesions. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289140PMC
July 2020
5.145 Impact Factor

Comparing genome-scale DNA methylation and CNV marks between adult human cultured ITGA6+ testicular cells and seminomas to assess in vitro genomic stability.

PLoS One 2020 16;15(3):e0230253. Epub 2020 Mar 16.

Center for Reproductive Medicine, Research Institute Reproduction and Development, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Autologous transplantation of spermatogonial stem cells is a promising new avenue to restore fertility in infertile recipients. Expansion of the initial spermatogonial stem cell pool through cell culturing is a necessary step to obtain enough cells for effective repopulation of the testis after transplantation. Since in vitro propagation can lead to (epi-)genetic mutations and possibly malignant transformation of the starting cell population, we set out to investigate genome-wide DNA methylation status in uncultured and cultured primary testicular ITGA6+ sorted cells and compare them with germ cell tumor samples of the seminoma subtype. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230253PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075560PMC

Expression of claudin-11 in canine prepubertal testes, and in canine adult testes showing normal spermatogenesis, impaired spermatogenesis, or testicular neoplasia.

Theriogenology 2020 May 5;148:122-131. Epub 2020 Mar 5.

Institute for Anatomy, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, 30173, Hannover, Germany. Electronic address:

The blood-testis barrier (BTB) consists of different cell-to-cell connections, including tight junction proteins like claudin-11 (CLDN11). For dogs, only limited data is published dealing with these proteins in general. Therefore, their physiological relevance, their postnatal expression, and their distribution pattern in pathological conditions, e. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2020.03.001DOI Listing

Management of residual disease after chemotherapy in germ cell tumors.

Curr Opin Oncol 2020 May;32(3):250-255

Division of Hematology & Medical Oncology - Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Purpose Of Review: Although testicular cancer remains a highly curable malignancy, challenges and uncertainty still remain in certain aspects of management. Residual disease after chemotherapy in patients with germ cell tumors (GCT) remains one of these challenges. We aim to highlight the recent literature on the management of residual disease after chemotherapy in GCT and the emerging innovations that may provide further guidance into this area. Read More

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http://dx.doi.org/10.1097/CCO.0000000000000619DOI Listing

Evaluation of nuclear NF-κB, transglutaminase2, and ERCC1 as predictors of platinum resistance in testicular tumors.

Int Braz J Urol 2020 May-Jun;46(3):353-362

Programa de Pós-Graduação em Medicina e Ciências da Saúde, Escola de Medicina e Laboratório de Farmacologia Aplicada, Escola de Ciências da Saúde, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brasil.

Purpose: Testicular germ cells tumor (TGCT) are associated with a high cure rate and are treated with platinum-based chemotherapy. However, a group of testicular cancer patients may have a very unfavorable evolution and insensitivity to the main therapeutic agent chemotherapy (CT) cisplatin. The aim of this study was to evaluate the risk of recurrence and overall survival related to the expression of nuclear factor kappa-B (NF-κB), transglutaminase 2 (TG2) and excision repair cross-complementation group 1 (ERCC1) in patients with TGCT treated with platinum combinations. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2019.0011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088506PMC
January 2019

[Late Recurrence of Seminoma Diagnosed by Endoscopic Ultrasound-Guided Fine Needle Aspiration in a Retroperitoneal Lymph Node].

Hinyokika Kiyo 2020 Feb;66(2):53-57

The Department of Urology, Osaka Rosai Hospital.

The patient was a 43-year-old man. At 30 years of age, he underwent high-inguinal orchiectomy for a right testicular tumor and was diagnosed with seminoma pT1N0M0. The patient had been followed without additional treatment and had dropped out 7 years after surgery. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_66_2_53DOI Listing
February 2020

Application of miRNAs in the diagnosis and monitoring of testicular germ cell tumours.

Nat Rev Urol 2020 04 10;17(4):201-213. Epub 2020 Mar 10.

Department of Urology, Hodentumorzentrum Hamburg, Asklepios Klinik Altona, Hamburg, Germany.

Testicular germ cell tumours (TGCTs) are the most frequent cancer type in young men and originate from the common precursor germ cell neoplasia in situ (GCNIS). For decades, clinical management of patients with TGCT has relied on classic serum tumour markers: α-fetoprotein, human chorionic gonadotropin subunit-β and lactate dehydrogenase. In the past 10 years, microRNAs have been shown to outperform classic serum tumour markers in the diagnosis of primary tumours and in follow-up monitoring and prediction of relapse. Read More

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http://dx.doi.org/10.1038/s41585-020-0296-xDOI Listing