72,612 results match your criteria Testicular Choriocarcinoma


Potential Role of microRNA-183 as a Tumor Suppressor in Hepatocellular Carcinoma.

Cell Physiol Biochem 2018 Dec 6;51(5):2065-2072. Epub 2018 Dec 6.

Department of General Surgery of East District, The Second Hospital of Hebei Medical University, Shijiazhuang,

Background/aims: Disseminated tumors, known as metastases, are responsible for ninety-percent of mortality due to cancer. Epithelial to mesenchymal transition, a phenomenon required for morphological conversion of non-motile discoid shaped epithelial cells to highly motile spindle-shaped mesenchymal cells, is thought to be a pre-requisite for metastatic progression. Metastasis-associated 1 (MTA1) protein is a prime inducer of EMT and metastatic progression in all solid tumors including hepatocellular carcinoma (HCC). Read More

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December 2018
8 Reads

Surgical practice among pediatric surgeons and pediatric urologists in the Kingdom of Saudi Arabia for the management of suspected testicular torsion.

Saudi Med J 2018 Dec;39(12):1232-1237

Division of Pediatric Surgery, Department of Surgery, College of Medicine, Taibah University, Almadinah Al-munawarah, Kingdom of Saudi Arabia. E-mail.

Objectives: To review and compare clinical practice and experience among pediatric surgeons (PS) and pediatric urologists (PU) for the management of testicular torsion (TT) in the Kingdom of Saudi Arabia (KSA).

Methods: This was a cross-sectional study conducted between August 2016 and November 2017, among all PU and PS involved in the management of suspected TT in KSA. A questionnaire was distributed to participants through the Survs. Read More

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December 2018

Predictive significance of serum inhibin B on testicular haploid gamete retrieval outcomes in nonobstructive azoospermic men.

Asian J Androl 2018 Nov 30. Epub 2018 Nov 30.

Center for Reproductive Medicine, Shandong University, Jinan 250001, China.

The purpose of this study was to determine the diagnostic accuracy of serum inhibin B (INHB) as a predictor of the retrieval outcome of testicular haploid gametes (spermatids and testicular spermatozoa) in nonobstructive azoospermic men. Serum hormone levels, testicular volume, and histological evaluation were performed in 403 Chinese nonobstructive azoospermic men. Testicular haploid gamete was successfully retrieved in 213 of 403 patients (52. Read More

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November 2018

Testosterone therapy to prevent type 2 diabetes mellitus in at-risk men (T4DM): Design and implementation of a double-blind randomised controlled trial.

Diabetes Obes Metab 2018 Dec 5. Epub 2018 Dec 5.

Medical School, University of Western Australia, and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Western Australia, Australia.

Background: Low circulating testosterone is associated with an increased risk of developing type 2 diabetes (T2DM) in overweight men with impaired glucose tolerance (IGT).

Aim: To determine in a multi-centre, double-blinded placebo-controlled randomised trial, whether testosterone treatment combined with lifestyle intervention (Weight Watchers®) relative to lifestyle intervention alone, reduces T2DM incidence and improves glucose tolerance at 2 years.

Study Population: Overweight or obese men aged 50-74 years with a serum testosterone of ≤14nmol/L and IGT or newly diagnosed T2DM established by an oral glucose tolerance test (OGTT). Read More

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December 2018
1 Read

Recombinant Human FSH Treatment Outcomes in Five Boys With Severe Congenital Hypogonadotropic Hypogonadism.

J Endocr Soc 2018 Dec 15;2(12):1345-1356. Epub 2018 Oct 15.

University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Context: Recombinant human FSH (r-hFSH), given to prepubertal boys with hypogonadotropic hypogonadism (HH), may induce Sertoli cell proliferation and thereby increase sperm-producing capacity later in life.

Objective: To evaluate the effects of r-hFSH, human chorionic gonadotropin (hCG), and testosterone (T) in such patients.

Design And Setting: Retrospective review in three tertiary centers in Finland between 2006 and 2016. Read More

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December 2018

Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor.

J Cancer 2018 31;9(23):4440-4448. Epub 2018 Oct 31.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

MPHOSPH1, which is one of the kinesin superfamily proteins, has been reported to play an essential role in the carcinogenesis and progression of several kinds of cancers. MPHOSPH1 has also been suggested to be involved in STAT3 phosphorylation in hepatocellular carcinoma. However, the biological behavior of MPHOSPH1 in testicular germ cell tumors (TGCTs) is unclear at present. Read More

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October 2018

Deep learning for detecting tumour-infiltrating lymphocytes in testicular germ cell tumours.

J Clin Pathol 2018 Dec 5. Epub 2018 Dec 5.

Nuffield Department of Surgical Sciences and NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.

Aims: To evaluate if a deep learning algorithm can be trained to identify tumour-infiltrating lymphocytes (TILs) in tissue samples of testicular germ cell tumours and to assess whether the TIL counts correlate with relapse status of the patient.

Methods: TILs were manually annotated in 259 tumour regions from 28 whole-slide images (WSIs) of H&E-stained tissue samples. A deep learning algorithm was trained on half of the regions and tested on the other half. Read More

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December 2018

Comparative Effects of Estrogen and Phytoestrogen, Genistein on Testicular Activities of Streptozotocin-Induced Type 2 Diabetic Mice.

Reprod Sci 2018 Dec 5:1933719118815576. Epub 2018 Dec 5.

3 Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

The aim of this study was to compare the effect of synthetic estrogen (E2) with a phytoestrogen and genistein in ameliorating type 2 diabetes mellitus (T2D)-mediated testicular dysfunction in mice. The streptozotocin (STZ)-induced type 2 diabetic mice were treated exogenously with either E2 or genistein for 2 durations and compared their effects on testicular activities, serum glucose, and insulin level. Type 2 diabetic mice treated with E2 for only short term (14 days) improved regressive changes in the testicular histology by increasing testosterone synthesis and improving insulin sensitivity, whereas those treated for longer duration (28 days) failed to improve testicular dysfunctions. Read More

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December 2018

Germ cell neoplasia in situ complicating 17β-hydroxysteroid dehydrogenase type 3 deficiency.

Mol Cell Endocrinol 2018 Nov 30. Epub 2018 Nov 30.

Division of Metabolism, Endocrinology, & Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA.

17β-hydroxysteroid dehydrogenase type 3 (17βHSD3) deficiency is an autosomal recessive disorder of male sex development that results in defective testosterone biosynthesis. Although mutations in the cognate HSD17B3 gene cause a spectrum of phenotypic manifestations, the majority of affected patients are genetic males having female external genitalia. Many cases do not present until puberty, at which time peripheral conversion of androgen precursors causes progressive virilization. Read More

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November 2018

Endocrine aspects of Klinefelter syndrome.

Curr Opin Endocrinol Diabetes Obes 2018 Nov 30. Epub 2018 Nov 30.

Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Purpose Of Review: Klinefelter syndrome is the most common sex chromosome abnormality in men. Hypogonadism and testicular degeneration are almost universal. Truncal adiposity, metabolic syndrome and low bone mass occur frequently. Read More

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November 2018

Resveratrol improves sperm parameter and testicular apoptosis in cisplatin-treated rats: Effects on ERK1/2, JNK, and Akt pathways.

Authors:
Ali A Shati

Syst Biol Reprod Med 2018 Dec 3:1-14. Epub 2018 Dec 3.

a Department of Biology , College of Science, King Khalid University , Abha , Saudi Arabia.

This study aimed to investigate the protective role of resveratrol (RES) against cisplatin (Cis)-induced testicular damage and reproductive dysfunction in rats and to examine the underlying mechanisms of protection including its effect on endoplasmic reticulum (ER) stress, P53, extracellular signal-regulated kinase (ERK)-1/2, stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and Protein kinase B (Akt) signaling. Eight-week-old Rats were divided into four groups (n = 12 each) of 1) control group: received normal saline (i.p. Read More

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December 2018

Phyllanthus emblica leaf extract ameliorates testicular damage in rats with chronic stress.

J Zhejiang Univ Sci B 2018 Dec.;19(12):948-959

Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

Stress affects the male reproductive system and can cause sub-fertility or infertility. Although Phyllanthus emblica L. (PE) extract has been shown to have high antioxidant capacity and protective properties in damaged tissue, the preventive effects of PE extract on testicular function from stress-related impairment have never been demonstrated. Read More

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December 2018

Scintigraphic evaluation of colonic transit in children with constipation using Ga-citrate.

World J Nucl Med 2018 Oct-Dec;17(4):249-252

Hospital de Base do Distrito Federal - Nuclear Medicine Service, Brasília, Brasil.

The aim of this study was to assess the colonic transit in children and teenagers with chronic constipation. Twenty patients from 1.5 to 16 years old were included (mean age = 6. Read More

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December 2018

Ellagic and ferulic acids protect arsenic-induced male reproductive toxicity via regulating Nfe2l2, Ppargc1a and StAR expressions in testis.

Toxicology 2018 Nov 29. Epub 2018 Nov 29.

Reproductive Physiology Laboratory, Animal Physiology Division, ICAR-National Institute of Animal Nutrition and Physiology, Adugodi, Bengaluru 560030, India.

Arsenic (As) - induced oxidative stress causes male reproductive toxicity apart from its other generalized systemic effects. Some phytochemicals through their antioxidant properties might help overcome such toxic effects. The aim of the study was to elucidate the protective role of the selected phytochemicals, ellagic and ferulic acids against the As-induced reproductive toxicity. Read More

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November 2018

Is excision of testicular nubbin necessary in vanishing testis syndrome?

J Pediatr Surg 2018 Dec 2;53(12):2495-2497. Epub 2018 Sep 2.

Department of Paediatric Surgery, John Hunter Children's Hospital, Newcastle, Australia; University of Newcastle, Priority Research Centre GrowUpWell, Newcastle, Australia. Electronic address:

Background/purpose: Vanishing Testes Syndrome (VTS) is one of the most common causes of impalpable testes in children. The role of removal of testicular nubbins owing to malignant potential in VTS is unclear. We sought to evaluate whether testicular nubbins need to be excised owing to this potential. Read More

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December 2018
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Immunolocalization of RFamide-related peptide 3 in a desert rodent Gerbillus tarabuli during seminiferous epithelium cycle.

Tissue Cell 2018 Dec 20;55:1-12. Epub 2018 Sep 20.

USTHB, University of Sciences and Technology of Houari Boumediene, Biological Sciences Faculty, Aride Area Research Laboratory, Algiers, Algeria.

Gerbillus tarabuli is a nocturnal seasonal breeder desert rodent with a main breeding season in spring and summer, and sexual quiescence in winter. This species is an interesting model for studying testis function in rodents. Therefore, the present study was performed firstly to investigate the stages of seminiferous epithelium cycle of Gerbillus tarabuli with a histological, morphometric and statistical study. Read More

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December 2018

Remote ischemic conditioning in a rat model of testicular torsion: does it offer testicular protection?

J Pediatr Urol 2018 Sep 24. Epub 2018 Sep 24.

Division of Urology, Beirut, Lebanon. Electronic address:

Background: Testicular torsion is a surgical emergency mainly affecting adolescent boys, with a relatively high rate of missed torsion and testicular loss secondary to delay in prompt diagnosis and surgical intervention. With ischemic reperfusion injury as its underlying culprit, testicular torsion may respond favorably to remote ischemic conditioning (RIC) where a non-privileged site (e.g. Read More

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September 2018

Leukemia and male infertility: past, present, and future.

Leuk Lymphoma 2018 Dec 3:1-10. Epub 2018 Dec 3.

a The Shraga Segal Dept. of Microbiology, Immunology, and Genetics , Ben-Gurion University of the Negev , Beer-Sheva , Israel.

Spermatogenesis is the process of the proliferation and differentiation of spermatogonial stem cells (SSCs) to generate sperm. Leukemia patients show impairment in some of the endocrine hormones that are involved in spermatogenesis. They also show a decrease in semen parameters before and after thawing of cryopreserved samples compared to a control. Read More

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December 2018

Development of Spermatogenesis In Vitro in Three-Dimensional Culture from Spermatogonial Cells of Busulfan-Treated Immature Mice.

Int J Mol Sci 2018 Nov 29;19(12). Epub 2018 Nov 29.

The Shraga Segal Department of Microbiology, Immunology, and Genetics, Beer-Sheva 84105, Israel.

Aggressive chemotherapy may lead to permanent male infertility. Prepubertal males do not generate sperm, but their testes do contain spermatogonial cells (SPGCs) that could be used for fertility preservation. In the present study, we examined the effect of busulfan (BU) on the SPGCs of immature mice, and the possible induction of the survivor SPGCs to develop spermatogenesis in 3D in-vitro culture. Read More

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November 2018

High-risk human papillomavirus in semen is associated with poor sperm progressive motility and a high sperm DNA fragmentation index in infertile men.

Hum Reprod 2018 Dec 4. Epub 2018 Dec 4.

Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.

Study Question: Does the presence of human papillomavirus (HPV) in semen impact seminal parameters and sperm DNA quality in white European men seeking medical help for primary couple's infertility?

Summary Answer: HPV seminal infections involving high-risk (HR) genotypes are associated with impaired sperm progressive motility and sperm DNA fragmentation (SDF) values.

What Is Known Already: HPV is commonly present in semen samples. However, whether the presence of HPV in semen is actually associated with impaired sperm parameters and SDF values have yet to be elucidated. Read More

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December 2018
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Expression profiles and characteristics of human lncRNA in normal and asthenozoospermia sperm.

Biol Reprod 2018 Dec 4. Epub 2018 Dec 4.

Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China.

Increasing studies have shown that specific mRNAs and miRNAs expressed in mature sperm may be related to sperm motility. However, the expression profiles and roles of lncRNAs in sperm remain unknown. In the present study, numerous lncRNAs were identified in human sperm, and some lncRNAs were expressed exclusively in sperm and testis. Read More

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December 2018

Down-regulation of steroidogenesis-related genes and its accompanying fertility decline in streptozotocin-induced diabetic male rats: ameliorative effect of metformin.

Andrology 2018 Dec 4. Epub 2018 Dec 4.

Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.

Background: Metformin has long been used for glycemic control in diabetic state. Recently, other benefits of metformin beyond blood glucose regulation have emerged.

Objectives: To investigate the effect of metformin on the expression of testicular steroidogenesis-related genes, spermatogenesis, and fertility of male diabetic rats. Read More

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December 2018

Persistence and Sexual Transmission of Filoviruses.

Viruses 2018 Dec 2;10(12). Epub 2018 Dec 2.

Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.

There is an increasing frequency of reports regarding the persistence of the Ebola virus (EBOV) in Ebola virus disease (EVD) survivors. During the 2014⁻2016 West African EVD epidemic, sporadic transmission events resulted in the initiation of new chains of human-to-human transmission. Multiple reports strongly suggest that these re-emergences were linked to persistent EBOV infections and included sexual transmission from EVD survivors. Read More

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December 2018

Solitary Bone Metastasis as the First Presentation of Germ Cell Testicular Cancer Treated with Internal Hemipelvectomy: A Case Report.

Urol Int 2018 Dec 4:1-4. Epub 2018 Dec 4.

Department of Pelvic Surgery, A.C. Camargo Cancer Center, São Paulo, Brazil.

Solitary bone metastasis from testicular tumor is rare. In literature, only few cases of isolated bone metastasis at first presentation have been reported, and none of them have been treated with extended surgery of the pelvic bone. Case Presentation: We report the case of a 33-year-old man with an iliac bone osteolytic metastasis as the first presentation of a non-seminomatous germ-cell testis tumor (NSGCT), treated with post-chemotherapy en bloc resection of residual tumor in the left iliac bone (Type I + II internal hemipelvectomy). Read More

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December 2018
2 Reads

Identification of SEPTIN12 as a novel target of the androgen and estrogen receptors in human testicular cells.

Biochimie 2018 Dec 1. Epub 2018 Dec 1.

Department of Biological Sciences and Technology, National University of Tainan, Tainan, Taiwan. Electronic address:

SEPTIN12 (SEPT12) is a testis-enriched gene that is downregulated in the testis of infertile men with severe spermatogenic defects. While SEPT12 is involved in spermatogenic failure and sperm motility disorder, SEPT12 transcriptional regulation is still unknown. Here we report the promoter region of SEPT12 as a 245 bp segment upstream from the transcription start site. Read More

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December 2018
1 Read

Diabetes-induced testicular oxidative stress, inflammation, and caspase-dependent apoptosis: the protective role of metformin.

Arch Physiol Biochem 2018 Dec 4:1-12. Epub 2018 Dec 4.

a Department of Physiology, School of Medical Sciences , Universiti Sains Malaysia , Kubang Kerian , Kelantan , Malaysia.

Context: Metformin's effect on glycaemic control is well documented, but its effect on diabetes-induced testicular impairment has been scarcely reported.

Objective: To investigate the effects of metformin on testicular oxidative stress, inflammation, and apoptosis, which largely contribute to fertility decline in diabetic state.

Methods: Male Sprague-Dawley rats were divided into 3 groups (n = 6/group) namely: normal control (NC), diabetic control (DC), and metformin (300 mg/kg b. Read More

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December 2018
4 Reads

Arsenic aggravated reproductive toxicity in male rats exposed to lead during the perinatal period.

Toxicol Res (Camb) 2018 Nov 9;7(6):1191-1204. Epub 2018 Aug 9.

Department of Zoology , Sri Venkateswara University , Tirupati - 517502 , India . Email: ; ; Tel: +91-9247593000.

The aim of this study was to assess the reproductive toxic effects of arsenic on adult Wistar rats exposed to lead during the perinatal period. The pregnant rats were allowed access to tap water containing 819 mg of lead (Pb) per L or without Pb from conception until weaning. Litter size, survival rate and developmental milestones of the pups delivered by Pb exposed dams were comparable to those of the control rats. Read More

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November 2018

Cellular and molecular mechanisms of sulfur mustard toxicity on spermatozoa and male fertility.

Toxicol Res (Camb) 2018 Nov 9;7(6):1029-1035. Epub 2018 Jul 9.

Chemical Injuries Research Center , Systems biology and poisonings institute , Baqiyatallah University of Medical Sciences , Tehran , Iran . Email: ; Tel: +21-82482502.

Sulfur mustard (SM) is a toxic compound that can target human spermatozoa. SM induces a wide variety of pathological effects in human reproductive organs, including sexual hormone disturbance, testicular atrophy, impaired spermatogenesis, poor sperm quality, defects in embryo development, childhood physical abnormalities, and severe fertility problems. However, the molecular and cellular mechanisms of SM action on male reproductive health and human sperm function are unclear. Read More

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November 2018
2 Reads

Segmental testicular infarction following nephrectomy.

Radiol Case Rep 2019 Feb 28;14(2):278-281. Epub 2018 Nov 28.

Department of Radiology, Royal London Hospital, Barts Health NHS Trust, Whitechapel Road, Whitechapel, E1 1BB, UK.

Segmental testicular infarction is a rare diagnosis and there are few documented cases in the literature. Those cases that have been reported are usually in the setting of epididymitis, hypercoaguable states, vasculitis, sickle cell disease, post orchidopexy or vasectomy, and idiopathic. We report a case of a patient who developed segmental testicular infarction that was managed conservatively, following nephrectomy for a ruptured kidney and the associated ultrasonographic appearances. Read More

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February 2019

Complete urological evaluation including sperm DNA fragmentation in male systemic lupus erythematosus patients.

Lupus 2018 Dec 3:961203318815764. Epub 2018 Dec 3.

1 Discipline of Urology, Hospital das Clinicas HCFMUSP, Sao Paulo, Brazil.

Objective: To evaluate sperm DNA fragmentation analysis in non-azoospermic male systemic lupus erythematosus (SLE) patients.

Methods: Twenty-eight consecutive male SLE patients (American College of Rheumatology criteria) and 34 healthy controls were evaluated for demographic/exposures data, urological evaluation, hormone profile and sperm analysis (including sperm DNA fragmentation). Clinical features, disease activity/damage scores and treatment were also evaluated. Read More

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December 2018

Transverse testicular ectopia associated with persistent Müllerian duct syndrome treated by transseptal orchiopexy: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13305

Departments of Urology.

Rationale: Persistent Müllerian duct syndrome (PMDS) is rare form of male pseudohermaphroditism characterized by the presence of uterus and fallopian tubes with normal external genitalia and secondary sexual characteristics. Transverse testicular ectopia (TTE) is also a rare form of testicular ectopia that may be associated with PMDS.

Patient Concerns: We present a 2-year-old boy who presented with bilateral non-palpable testes with left inguinal mass. Read More

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November 2018
1 Read

A practical approach to adjusting for population stratification in genome-wide association studies: principal components and propensity scores (PCAPS).

Stat Appl Genet Mol Biol 2018 Dec 4. Epub 2018 Dec 4.

Division of Population Sciences, Dana Farber Cancer Institute and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA.

Genome-wide association studies (GWAS) are susceptible to bias due to population stratification (PS). The most widely used method to correct bias due to PS is principal components (PCs) analysis (PCA), but there is no objective method to guide which PCs to include as covariates. Often, the ten PCs with the highest eigenvalues are included to adjust for PS. Read More

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December 2018

Different effects of α-endosulfan, β-endosulfan, and endosulfan sulfate on sex hormone levels, metabolic profile and oxidative stress in adult mice testes.

Environ Res 2018 Nov 20;169:315-325. Epub 2018 Nov 20.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Beijing 100193, China. Electronic address:

In the environment, endosulfan persists in forms of two isomers (α and β) and a toxic metabolite, endosulfan sulfate. The toxicity of endosulfan on various mammalian tissues has been investigated, but whether the different isomers and metabolites of endosulfans affect mammalian reproductive function remains unclear. This study is aimed to elucidate the different toxicological effects of α-endosulfan, β-endosulfan, and endosulfan sulfate on adult mice testes. Read More

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November 2018

Food Yellow4 reprotoxicity in relation to localization of DMC1 and apoptosis in rat testes: Roles of royal jelly and cod liver oil.

Ecotoxicol Environ Saf 2018 Nov 27;169:696-706. Epub 2018 Nov 27.

Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita-Ku, Sapporo, Japan.

Food Yellow 4 (FY4) is a lemon-yellow-colored synthetic organic azo dye, which is used widely for imparting pleasant and attractive appearance to foods and cosmetics. The present study aimed at evaluating the possible mechanism underlying the FY4-induced reprotoxicity in rats, and the potential supportive role of royal jelly (RJ) or cod liver oil (CLO), which is a natural remedy with several pharmacological benefits, against induced toxicity. Forty-eight male rats were divided into different groups-the control group, the CLO group (0. Read More

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November 2018
2 Reads

Roles of estrogens in fish sexual plasticity and sex differentiation.

Gen Comp Endocrinol 2018 Nov 27. Epub 2018 Nov 27.

Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, 400715 Chongqing, PR China. Electronic address:

Fish sex could be reversed at the undifferentiated stage of gonad by administration of exogenous estrogen (E2) or blockade of endogenous estrogen synthesis with aromatase inhibitors, which is designated as primary sex reversal (PSR). Recent studies have well demonstrated that gonochoristic fish maintain their sexual plasticity after sex determination/differentiation. The differentiated ovary could be transdifferentiated into functional testis, and vice versa, the differentiated testis could be transdifferentiated into ovary. Read More

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November 2018
1 Read

Subnutrition Effects During Pregnancy and Lactation on Mitosis, Apoptosis, and Androgen Receptor Expression in the Rat Testis.

Reprod Domest Anim 2018 Nov 30. Epub 2018 Nov 30.

Area of Histology and Embryology, Department of Morphology and Development, Veterinary Faculty, University of Uruguay.

In order to study the effect of undernutrition during gestation on the testicular development in rats and its impact on mitosis, apoptosis and the relative abundance of androgen receptor expression, twenty primiparous 3 months old Sprague-Dawley (Rattus norvegicus) rats, weighing 246 ± 4,0 grams when the experiment began, were mated by the same male. Control group (CG), n=10, fed ad libitum with water and rat chow and restricted group (RG, n=10), fed throughout pregnancy and until birth with 40% of the ad libitum maternal daily feed intake. Litters from both groups suckled for 25 days, RG with 14 pups/litter and CG with 8 pups/litter. Read More

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November 2018
1 Read

Short rare minisatellite variant of BORIS-MS2 is related to bladder cancer susceptibility.

Genes Genomics 2018 Nov 29. Epub 2018 Nov 29.

Department of Biological Sciences, Dong-A University, Busan, 49315, South Korea.

Background: BORIS/CTCFL, a paralog of CTCF and member of the cancer-testicular antigen family, is abnormally activated in multiple cancers.

Objective: We investigated the relationship between polymorphic variants of the BORIS minisatellite 2 (BORIS-MS2), located within the 5' upstream promoter region of BORIS, and bladder cancer.

Methods: We used case-control study with 516 controls and 113 bladder cancer patients. Read More

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November 2018

Incidence of Y chromosome microdeletions in patients with Klinefelter syndrome.

J Endocrinol Invest 2018 Nov 29. Epub 2018 Nov 29.

Laboratory of Seminology-Sperm Bank "Loredana Gandini", Department of Experimental Medicine, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.

Purpose: The aim of this study was to study the incidence of Y chromosome microdeletions in a Caucasian population of Klinefelter syndrome (KS) patients and to investigate the possible association between Y chromosome microdeletions and KS.

Materials And Methods: We conducted a retrospective study on 118 KS patients, 429 patients with non-obstructive azoospermia (NOA), and 155 normozoospermic men. Eight of the 118 KS patients had undergone testicular sperm extraction (TESE). Read More

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November 2018
1 Read

Motor neuron involvement in anti-Ma2-associated paraneoplastic neurological syndrome.

J Neurol 2018 Nov 29. Epub 2018 Nov 29.

French Reference Center of Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Hôpital Neurologique, Lyon, France.

Objective: To present clinical, radiological, and pathological features of a cohort of patients with motor neuron involvement in association with anti-Ma2 antibodies (Ma2-Ab).

Methods: Retrospective case-series of patients with definite paraneoplastic neurological syndrome (PNS) and Ma2-Ab, and cases identified from a review of the literature.

Results: Among 33 Ma2-Ab patients referred between 2002 and 2016, we retrospectively identified three patients (9. Read More

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November 2018

Sexual Enhancing Effect of in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions.

Biomed Res Int 2018 25;2018:6452965. Epub 2018 Oct 25.

Department of Physiology, Faculty of Medicine, Khon Kaen University, 40002, Thailand.

In this study, we aimed to assess the effect and possible underlying mechanism of leaves extract on male sexual behaviors in stress-exposed rats. Male Wistar rats were orally given extract at doses of 25, 100, and 200 mg/kg BW before 12-hour-immobilization exposure for 14 days. Sexual behaviors, serum testosterone and corticosterone levels, TH-positive cells density in nucleus accumbens (NAc) and ventral tegmental area (VTA), MAO-B activity in NAc and medial preoptic area (MPOA), testis histology together with phosphodiesterase type-5 ( PDE-5) activity, and endothelial nitric oxide synthase (eNOS) expression in penis were evaluated after treatment. Read More

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October 2018
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DIFFERENTIAL HISTOPATHOLOGICAL ASSESSMENT OF TESTICULAR FUNCTION UPON LONG-TERM EXPOSURE TO SUSTAINED DELIVERY OF TESTOSTERONE AND DIHYDROTESTOSTERONE.

Biomed Sci Instrum 2018 Apr;54(1):138-144

Jackson State University, Jackson, MS.

The specific aim of this study was to assess, histopathologically, the seminiferous tubules area and germ layers upon the exposure to sustained delivery of testosterone (TE) and dihydrotestosterone (DHT) through tricalcium phosphate lysine devices (TCPL). A total of 140 adult Male rats (280-320 gm) were randomly divided into four equal groups. Groups 1 and 2 animals were implanted with TCPL loaded with 40 mg TE and 40 mg DHT, respectively. Read More

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Testicular Cancer Biomarkers: A Role for Precision Medicine in Testicular Cancer.

Clin Genitourin Cancer 2018 Oct 23. Epub 2018 Oct 23.

Division of Urology, Department of Surgery, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Testicular germ cell tumors (TGCTs) represent the most common solid tumors among men aged 15 to 34 years. Fortunately, recent advances have made testicular cancer a highly curable disease. Despite the high cure rates, there are still several areas in testis cancer care where treatment decisions are controversial and guided only with clinical factors and historic serum tumor markers. Read More

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October 2018
1 Read

Taurine ameliorates oxidative stress induced inflammation and ER stress mediated testicular damage in STZ-induced diabetic Wistar rats.

Food Chem Toxicol 2018 Nov 26;124:64-80. Epub 2018 Nov 26.

Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata, 700054, India. Electronic address:

One of the major consequences of diabetes is reproductive dysfunction but the fundamental mechanisms are still poorly known. The objective of the present study was to explore the beneficial role of taurine against streptozotocin induced testicular dysfunctions in diabetic male Wister rats and understanding the underlying intricate molecular mechanisms. Exposure to streptozotocin (50 mg kg body weight, i. Read More

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November 2018
3 Reads
2.895 Impact Factor

Genetically inherited - and high fat diet induced - obesity differentially alters spermatogenesis in adult male rats.

Endocrinology 2018 Nov 28. Epub 2018 Nov 28.

Department of Neuroendocrinology, National Institute for Research in Reproductive Health (ICMR), Parel, Mumbai, India.

Obesity is a multifactorial disorder with predominantly genetic and/or environmental causes. Thus, our aim was to delineate effects of genetically inherited and high fat diet induced obesity on fertility and spermatogenesis using two Wistar rat models: genetically inherited obese (GIO): WNIN/Ob and diet induced obese (DIO): High fat diet. The terminal body weights were similar in both GIO and DIO groups, but, there was a significant difference in metabolic and hormone profile between the two groups. Read More

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November 2018
1 Read

TargetClone: A multi-sample approach for reconstructing subclonal evolution of tumors.

PLoS One 2018 29;13(11):e0208002. Epub 2018 Nov 29.

Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.

Most tumors are composed of a heterogeneous population of subclones. A more detailed insight into the subclonal evolution of these tumors can be helpful to study progression and treatment response. Problematically, tumor samples are typically very heterogeneous, making deconvolving individual tumor subclones a major challenge. Read More

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November 2018

Vertical Hyperreflective Lesions on Optical Coherence Tomography in Vitreoretinal Lymphoma.

JAMA Ophthalmol 2018 Nov 29. Epub 2018 Nov 29.

Feinberg School of Medicine, Department of Ophthalmology, Northwestern University, Chicago, Illinois.

Importance: Vitreoretinal lymphoma is a diagnostic challenge and the pathophysiology is still unclear.

Objective: To describe an imaging finding seen on optical coherence tomography (OCT) of patients with vitreoretinal lymphoma.

Design, Setting, And Participants: This case series study was a retrospective medical record review of patients who received a diagnosis of vitreoretinal lymphoma at the Department of Ophthalmology at Northwestern University between July 2014 and January 2016. Read More

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November 2018
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Chlorella vulgaris ameliorates testicular toxicity induced by deltamethrin in male rats via modulating oxidative stress.

Andrologia 2018 Nov 29:e13214. Epub 2018 Nov 29.

Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

This study was carried out to investigate the potential effects of Chlorella vulgaris (CV) on testicular function and oxidant/antioxidant status in normal and deltamethrin-intoxicated rats. Forty adult male rats were drenched either with normal saline, CV (50 mg/kg), deltamethrin (DM) (3 mg/kg), or CV combined with DM, daily for 8 weeks. At the end of the protocol, the epididymal sperm quality was evaluated and the testicular superoxide dismutase (SOD), catalase enzyme (CAT) and malondialdehyde (MDA), and the serum testosterone levels were estimated. Read More

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November 2018

Ectopic Organogenesis after Allotransplantation of Freshly Removed or Cryopreserved Neonatal Testicle under the Renal Capsule in Rats.

Bull Exp Biol Med 2018 Dec 28;166(2):268-273. Epub 2018 Nov 28.

All-Russian Institute of Scientific and Technical Information, Russian Academy of Sciences, Moscow, Russia.

In experiments on white outbred male rats, a freshly removed (20 experiments) or cryopreserved (10 experiments) testicle from newborn rats (1-2 days after birth) was transplanted under the renal capsule after bilateral orchiectomy. In all experiments with transplantation of freshly removed testicle, it was engrafted. In 3 months, histological examination revealed the formation of mature seminiferous tubules, but spermatogenesis was blocked at the stage of spermatogonia; groups of proliferating Leydig cells in the loose connective tissue between the tubules were also seen. Read More

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December 2018
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