1,205 results match your criteria Testicular Choriocarcinoma


New Anti-Cancer Strategies in Testicular Germ Cell Tumors.

Recent Pat Anticancer Drug Discov 2019 Jan 11. Epub 2019 Jan 11.

Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Scuola di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli #39;Federico II', Naples. Italy.

Background: The most common solid malignancy of young men aged 20 to 34 years is testicular germ cell tumor. In addition, the incidence of these tumors has significatively increased throughout the last years. Testicular germ cell tumors are classified into seminoma and nonseminoma germ cell tumors, which take in yolk sac tumor, embryonal cell carcinoma, choriocarcinoma, and teratoma. Read More

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http://www.eurekaselect.com/168893/article
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http://dx.doi.org/10.2174/1574892814666190111120023DOI Listing
January 2019
14 Reads

Choriocarcinoma Syndrome as an Initial Presentation of Testicular Cancer.

Case Rep Oncol Med 2018 8;2018:8065615. Epub 2018 Nov 8.

Centro Universitario Contra el Cáncer, University Hospital "Dr. José Eleuterio González" and Faculty of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.

Choriocarcinoma syndrome (CS) is a rare clinical entity within the spectrum of nonseminomatous germ-cell tumors (NSGCT). It is characterized by the abrupt establishment of rapidly progressive and hemorrhagic tumors associated with very high levels of the beta fraction of human chorionic gonadotropin (-hCG) and with a very poor prognosis, particularly in patients with -hCG values above 50,000 IU/L. We present the case of a 17-year-old man with a sudden onset nonmassive hemoptysis. Read More

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http://dx.doi.org/10.1155/2018/8065615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249998PMC
November 2018
8 Reads

Testicular Choriocarcinoma Metastasizing to the Small Bowel Causing Intussusception: Case Report.

J Gastrointest Cancer 2018 Oct 27. Epub 2018 Oct 27.

Pathology Department, Texas Tech Health and Science Center, El Paso, TX, USA.

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http://dx.doi.org/10.1007/s12029-018-0172-6DOI Listing
October 2018
2 Reads

CK7, inhibin, and p63 in testicular germ cell tumor: superior markers of Choriocarcinoma compared to β-hCG.

Hum Pathol 2018 Oct 22. Epub 2018 Oct 22.

Department of Pathology, The Ohio State University Medical Center, 410 W 10(th) Ave., 401 Doan Hall, Columbus, OH 43210. Electronic address:

Choriocarcinoma can be difficult to differentiate from other subtypes of testicular germ cell tumor and can occur unexpectedly in a distant, late metastasis. The aim of this investigation was to identify a marker superior to β-hCG for choriocarcinoma. 62 primary and metastatic testicular germ cell tumors (27 choriocarcinomas, 19 yolk sac tumors, 29 embryonal carcinomas, 28 seminomas, 22 teratomas, 3 epithelioid trophoblastic tumors (ETT)), were analyzed for immunohistochemical expression of CK7, inhibin, p63, and β-hCG. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183039
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http://dx.doi.org/10.1016/j.humpath.2018.10.007DOI Listing
October 2018
9 Reads
2.770 Impact Factor

Pure Testicular Choriocarcinoma with Dermatological, Brain, and Gastrointestinal Metastases.

Cureus 2018 Aug 1;10(8):e3083. Epub 2018 Aug 1.

Department of Internal Medicine, Dell Seton Medical Center at The University of Texas, Austin, USA.

Testicular choriocarcinoma is a non-seminomatous germ cell tumor (NSGCT) and is the rarest of all testicular cancers. Nearly all choriocarcinomas can be classified as either pure choriocarcinoma or as a component of a mixed germ cell tumor. Pure testicular choriocarcinoma is extremely aggressive and metastasizes early and extensively. Read More

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https://www.cureus.com/articles/13842-pure-testicular-chorio
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http://dx.doi.org/10.7759/cureus.3083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168053PMC
August 2018
3 Reads

Successful management of a patient with radiological presentation of choriocarcinoma syndrome before induction chemotherapy.

J Cancer Res Ther 2018 Sep;14(Supplement):S803-S805

Department of Urology and Andrology, Graduate School of Medicine, Kansai Medical University, Osaka, Japan.

Choriocarcinoma syndrome is a life-threatening lysis syndrome caused by blood vessel rupture and subsequent tumor bleeding. We describe a case of pretreatment choriocarcinoma syndrome that developed in a 27-year-old man. He underwent a high orchiectomy at a local hospital and was diagnosed with metastatic testicular tumor given the high serum human chorionic gonadotropin levels (943,601 mIU/mL). Read More

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http://www.cancerjournal.net/text.asp?2018/14/10/803/175433
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http://dx.doi.org/10.4103/0973-1482.175433DOI Listing
September 2018
16 Reads

c-MET receptor as potential biomarker and target molecule for malignant testicular germ cell tumors.

Oncotarget 2018 Aug 7;9(61):31842-31860. Epub 2018 Aug 7.

Department of Anatomy, Histology, Forensic-Medicine and Orthopaedics, "Sapienza" University of Rome, Italy.

Type II testicular germ cell tumors (TGCTs) represent the most frequent malignancy in Caucasian males (20-40 years). Even if diagnosed with disseminated disease, >80% of patients are cured; however, a small percentage of cases progress and result in death. It is commonly accepted that these cancers arise from a disturbed testicular embryonic niche that leads to the block of gonocyte differentiation. Read More

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http://www.oncotarget.com/fulltext/25867
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http://dx.doi.org/10.18632/oncotarget.25867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112764PMC
August 2018
13 Reads

Pure testicular choriocarcinoma presenting as a friable hemorrhagic nodule on the lip.

JAAD Case Rep 2018 Aug 15;4(7):705-707. Epub 2018 Aug 15.

Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah.

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http://dx.doi.org/10.1016/j.jdcr.2018.05.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098204PMC
August 2018
2 Reads

Chemotherapy for metastatic testicular cancer: The first nationwide multi-institutional study by the Cancer Registration Committee of the Japanese Urological Association.

Int J Urol 2018 08 17;25(8):730-736. Epub 2018 Jul 17.

Department of Urology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Objectives: To assess clinicopathological data and oncological outcomes focused on metastatic testicular cancer patients, who received chemotherapy as the initial treatment, in the nationwide multi-institutional study by the Cancer Registration Committee of the Japanese Urological Association.

Methods: A testicular cancer survey was carried out by the Japanese Urological Association in 2011 to register newly diagnosed testicular cancers in 2005 and 2008. Among 1121 registered patients, 278 patients with metastases who received chemotherapy as the initial treatment and could be categorized by the Japanese Urological Association classification were eligible for the analysis. Read More

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http://dx.doi.org/10.1111/iju.13720DOI Listing
August 2018
7 Reads

Dose-reduced first cycle of chemotherapy for prevention of life-threatening acute complications in nonseminomatous germ cell tumor patients with ultra high tumor markers and/or poor performance status.

J Cancer Res Clin Oncol 2018 Sep 5;144(9):1817-1823. Epub 2018 Jul 5.

Department of Clinical Pharmacology and Chemotherapy, N.N. Blokhin Russian Cancer Research Center, 24 Kashirskoye sh., Moscow, 115478, Russia.

Purpose: Patients with metastatic nonseminomatous germ cell tumors (mNSGCT) and a high tumor burden or a poor performance status at initial diagnosis are at risk from potentially life-threatening early complications during or after the first chemotherapy cycle. The outcomes with dose-reduced first cycle of chemotherapy in this population of patients are not well established.

Methods: We performed a retrospective analysis of patients with mNSGCT and International Germ Cell Cancer Collaborative Group (IGCCCG) poor risk features. Read More

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http://dx.doi.org/10.1007/s00432-018-2695-4DOI Listing
September 2018
31 Reads

Cutaneous Metastasis of Choriocarcinoma in 2 Male Patients: A Rare Presentation of an Aggressive Malignancy That Dermatopathologists Must Recognize.

Am J Dermatopathol 2019 Jan;41(1):50-54

Dartmouth Geisel School of Medicine, Hanover, NH.

Testicular choriocarcinoma needs to be considered in the differential diagnosis of cutaneous metastases in young adult men because of its propensity for early hematogenous dissemination. Furthermore, the diagnosis may not be suspected in many cases in which there is clinically no testicular enlargement. This highly aggressive germ cell tumor typically metastasizes to the liver, lungs, and brain. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001209DOI Listing
January 2019
1 Read

Cutaneous and systematic metastasis of testicular choriocarcinoma: Case report and literature review.

Medicine (Baltimore) 2018 Jun;97(22):e10736

Department of Urology, the First Affiliated Hospital of GuangXi Medical University.

Rationale: Cutaneous metastasis of testicular choriocarcinoma is exceptionally uncommon. To our knowledge, only 14 cases have been reported in the past 10 years in the pubmed. We have an uncommon case of testicular choriocarcinoma who has metastasized to the adjacent skin and organ systems. Read More

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http://dx.doi.org/10.1097/MD.0000000000010736DOI Listing
June 2018
4 Reads

The Clinical Significance of a Small Component of Choriocarcinoma in Testicular Mixed Germ Cell Tumor (MGCT).

Am J Surg Pathol 2018 Aug;42(8):1113-1120

The Johns Hopkins Medical Institutions, Baltimore, MD.

The clinical significance of limited choriocarcinoma in a malignant mixed germ cell tumor (MGCT) is unknown. Men with a MGCT with ≤5% choriocarcinoma at radical orchiectomy (RO) between 2000 and 2016 from our consult service were studied. Of 50 men in our cohort, we had clinical information for 30 men. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001088DOI Listing
August 2018
14 Reads

Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors.

Hum Pathol 2018 Nov 16;81:26-36. Epub 2018 May 16.

Division of Clinical Pathology, Geneva University Hospitals, 1205 Geneva, Switzerland.

Identification of the yolk sac tumor (YST) component in germ cell tumors (GCT) may prove challenging, and highly sensitive and specific immunohistochemical markers are still lacking. Preliminary data from the literature suggest that HNF1β may represent a sensitive marker of YST. The specificity of HNF1β has not been addressed in GCT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183015
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http://dx.doi.org/10.1016/j.humpath.2018.04.025DOI Listing
November 2018
13 Reads

Spontaneous renal hemorrhage secondary to choriocarcinoma in a man with congenital hypospadias and cryptorchidism: a case report and literature review.

BMC Cancer 2018 May 8;18(1):543. Epub 2018 May 8.

University College London Medical School, Medical School Building, 74 Huntley Street, London, WC1E 6BT, England, UK.

Background: Choriocarcinoma is a rare malignant germ-cell tumour, most commonly found in adult women. It infrequently presents as spontaneous renal haemorrhage (SRH). Genital malformation and SRH secondary to choriocarcinoma has previously been only reported in females. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-4424-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941373PMC
May 2018
5 Reads

Testicular choriocarcinoma with cutaneous metastasis in a 19-year-old man.

J Cutan Pathol 2018 Jul 16;45(7):535-538. Epub 2018 May 16.

Department of Medical Oncology, National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany.

A 19-year-old man suffering from testicular choriocarcinoma presented to the dermatology department with a cutaneous metastasis on his head. This metastasis was the first sign of disease that led to medical consultation. Histopathology revealed cytotrophoblasts and syncytiotrophoblasts, the later expressing human chorionic gonadotropin antigen. Read More

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http://dx.doi.org/10.1111/cup.13261DOI Listing
July 2018
4 Reads

Onco-testicular sperm extraction (Onco-TESE) from a single testis with metachronous bilateral testicular cancer: a case report.

Basic Clin Androl 2018 25;28. Epub 2018 Jan 25.

1Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562 Japan.

Background: Although oncologic testicular sperm extraction (onco-TESE) has been increasingly practiced, the evidence of onco-TESE performed in patients with testicular cancer is insufficient. Furthermore, in bilateral testicular cancer, accounting for 0.5%-1% of testicular cancers, onco-TESE is more challenging and has been insufficiently reported. Read More

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http://dx.doi.org/10.1186/s12610-018-0066-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785797PMC
January 2018
29 Reads

Placental Site Trophoblastic Tumor in Nonseminomatous Mixed Germ Cell Tumors of the Testis: a Case Report and Review of the Literature.

Clin Genitourin Cancer 2018 04 27;16(2):e349-e354. Epub 2017 Dec 27.

Service de Pathologie, Hôpital Saint-Louis, AP-HP, Paris, France; Service de Recherches en Hémato-immunologie, CEA, Hôpital Saint-Louis, Paris, France; Université Paris Diderot, UMR E_5, Institut Universitaire d'Hématologie, Paris, France; Université Paris Diderot, Inserm, UMR_S1165, Institut Universitaire d'Hématologie, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2017.12.010DOI Listing
April 2018
1 Read

Detailed pathologic analysis on the co-occurrence of non-seminomatous germ cell tumor subtypes in matched orchiectomy and retroperitoneal lymph node dissections.

Med Oncol 2018 Jan 31;35(3):21. Epub 2018 Jan 31.

Department of Pathology, University of Michigan Health System, Ann Arbor, MI, USA.

The frequency of co-occurrence between germ cell tumor (GCT) components in non-seminomatous germ cell tumor (NSGCT) orchiectomy specimens and their correlation with histologic findings in subsequent retroperitoneal lymph node dissection (RPLND) specimens have not been well characterized. The objective of the study was to report the first detailed clinicopathologic analysis of NSGCT orchiectomy and RPLND samples to determine the likelihood and agreement of the co-occurrence of GCT components. A total of 118 consecutive patients with NSGCT treated between 1988 and 2012 who underwent both orchiectomy and RPLND at a single academic tertiary care center were analyzed. Read More

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http://dx.doi.org/10.1007/s12032-018-1090-yDOI Listing
January 2018
14 Reads

[Primary mediastinal choriocarcinoma: A case report and literature review].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017 Oct;42(10):1222-1227

Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Primary mediastinal choriocarcinoma in male is not a very common disease, with nonspecific clinical manifestations. Gynecomastia and testicular atrophy are present in some cases. The levels of serum human chorionic gonadotropin are often significantly increased. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2017.10.016DOI Listing
October 2017
4 Reads

Burned-Out Testicular Cancer: Really a Different History?

Case Rep Oncol 2017 Sep-Dec;10(3):846-850. Epub 2017 Sep 20.

Policlinico Umberto I, Rome, Italy.

Two or more histological types characterize more than 60% of testicular germ cell tumors (GCTs). Burned-out testicular tumor refers to partial or complete histological regression of the primary testicular lesions. The most frequent GCT type involved in this kind of histological regression is choriocarcinoma, followed by embryonal carcinoma. Read More

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http://dx.doi.org/10.1159/000480493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649263PMC
September 2017
10 Reads

Recent Advances in New Discovered Molecular Targets in Testicular Germ Cell Tumors.

Authors:
Paolo Chieffi

Curr Med Chem 2018 Feb;25(5):575-583

Dipartimento di Psicologia, Universita degli Studi della Campania, 81100 Caserta, Italy.

Background: Testicular germ cell tumor (TGCT) is the most common solid malignancy occurring in young men between 20 and 34 years of age, and its incidence has increased significantly over the last decades. TGCTs can be subdivided into seminoma and nonseminoma germ cell tumors (NSGCTs), which includes yolk sac tumor, choriocarcinoma, embryonal cell carcinoma, and teratoma. Seminomas and NSGCTs present significant differences in therapy, prognosis, and both show characteristics of the Primordial Germ Cells (PGCs). Read More

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http://dx.doi.org/10.2174/0929867324666171003115807DOI Listing
February 2018
5 Reads

[Long-term follow up experience of comprehensive treatment of testicular mixed germ cell tumors].

Beijing Da Xue Xue Bao Yi Xue Ban 2017 08;49(4):648-651

Department of Urology, Peking University Third Hospital, Beijing 100191, China.

Objective: Testicular mixed germ cell tumor is mixed with embryonal carcinoma, choriocarcinoma, yolk sac tumor, teratoma, seminoma and other two or more components of the testicular tumor, the clinical is relatively rare and high degree of malignancy, this article will summarize its clinical features and optimize its treatment.

Methods: A retrospective analysis of the clinical data of 22 patients with testicular tumor mixed germ cell in Peking University Third Hospital from May 1994 to November 2016 was conducted using a combination of statistical analysis and discussion of the relevant literature.

Results: The mean age of the 22 patients was (30. Read More

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August 2017
6 Reads

Pitfalls in Diagnosis and Management of Testicular Choriocarcinoma Metastatic to the Brain: Report of 2 Cases and Review of Literature.

World Neurosurg 2017 Oct 13;106:536-542. Epub 2017 Jul 13.

Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, New York, USA.

Introduction: Pure choriocarcinoma of the testes is a rare, aggressive germ cell tumor that can metastasize to the brain. Although its prognosis has improved with the development of cisplatin-based chemotherapy regimens, cerebral metastases are prone to hemorrhage and associated with high morbidity. Here, we present 2 cases of testicular choriocarcinoma with cerebral metastasis and discuss potential pitfalls in their diagnosis and management. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.07.023DOI Listing
October 2017
18 Reads

Rare Presentation of Metastatic Cystic Trophoblastic Tumor in a Patient Without Prior Chemotherapy.

Urol Case Rep 2017 Jul 23;13:154-157. Epub 2017 May 23.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.

Cystic trophoblastic tumor (CTT) is a rare testicular germ cell tumor (GCT) predominantly seen in post-chemotherapy patients. It is prognostically similar to teratoma and requires no additional chemotherapy in the absence of a nonteratomatous GCT component. We report a case of metastatic CTT in a patient with primary testicular teratoma without prior chemotherapy. Read More

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http://dx.doi.org/10.1016/j.eucr.2017.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443920PMC
July 2017
8 Reads

Burned-out metastatic testicular tumor: Choriocarcinoma.

Int J Health Sci (Qassim) 2017 Apr-Jun;11(2):81-82

Department of Radiology, King Khalid University Hospital, King Saud University, P.O. Box 7805, Riyadh 11472, Saudi Arabia.

Burned-out testicular tumor is a very rare clinical entity. There is no clinical finding in the testicle because it regresses spontaneously without any treatment and generally presents with metastases. Clinical examination of the testis and scrotal sonography are pivotal in the initial diagnosis of such neoplasms. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426405PMC
May 2017
7 Reads

[Germ cell and sex cord-stromal tumors of the testis : WHO classification 2016].

Authors:
G Mikuz

Pathologe 2017 May;38(3):209-220

Institut für Pathologie, Universität Innsbruck, Müllerstraße 44, 6020, Innsbruck, Österreich.

Earlier revisions of the WHO classification of testicular tumors, which was originally published in 1977, contained only minor additions. In the WHO 2016 classification, in contrast, germ cell tumors are split into two major groups based on their distinct pathohistogenesis, i. e. Read More

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http://dx.doi.org/10.1007/s00292-017-0290-0DOI Listing
May 2017
27 Reads

Prognostic value of intratumoral carbonic anhydrase IX expression in testicular germ cell tumors.

Oncol Lett 2017 Apr 14;13(4):2177-2185. Epub 2017 Feb 14.

Translational Research Unit, Faculty of Medicine, Comenius University, 833 10 Bratislava, Slovak Republic.

Testicular germ cell tumors (TGCTs) represent a highly curable malignancy, however a small proportion of patients fails to be cured with cisplatin-based chemotherapy. Carbonic anhydrase IX (CA IX) is upregulated by hypoxia in several cancer types and correlates with a poor prognosis. The present translational study evaluated expression and prognostic value of CA IX in TGCTs. Read More

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http://dx.doi.org/10.3892/ol.2017.5745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403396PMC
April 2017
19 Reads

Polyembryoma of the testis: a report of two cases dominant within mixed germ cell tumors and review of gonadal polyembryomas.

Mod Pathol 2017 07 21;30(7):908-918. Epub 2017 Apr 21.

James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Two testicular mixed germ cell tumors, from men of 21 and 41 years, in which polyembryoma predominated are described. A literature review uncovered an additional five testicular and nine ovarian cases. One tumor occurred in a 60-year-old man, but all others occurred within the typical age range of gonadal germ cell tumors. Read More

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http://dx.doi.org/10.1038/modpathol.2017.25DOI Listing
July 2017
4 Reads

Incidental primary mediastinal choriocarcinoma diagnosed by endobronchial ultrasound-guided fine needle aspiration in a patient presenting with transient ischemic attack and stroke.

Diagn Cytopathol 2017 Aug 11;45(8):738-743. Epub 2017 Apr 11.

Department of Pathology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York.

We describe a case of a 41-year old male patient with no significant prior medical history who presents with symptoms of Transient Ischemic Attack and stroke. Magnetic Resonance Imaging (MRI) of the brain identified areas of ischemia in the left side, and angiography showed occlusion of the left Medial Cerebral Artery (MCA). Cardiac Transthoracic Echocardiogram (TTE) for stroke evaluation incidentally noted a mediastinal abnormality leading to cancer work-up. Read More

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http://doi.wiley.com/10.1002/dc.23719
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http://dx.doi.org/10.1002/dc.23719DOI Listing
August 2017
14 Reads

Primary Cystic Trophoblastic Tumor of the Testis: A Study of 14 Cases.

Am J Surg Pathol 2017 Jun;41(6):788-794

Indiana University School of Medicine, Indianapolis, IN.

Cystic trophoblastic tumor (CTT) has been described in postchemotherapy retroperitoneal lymph node dissections of patients with testicular germ cell tumors. Prognostically, this lesion is similar to teratoma and no further treatment is required after surgery in the absence of other components. CTT has not, however, been reported in the testis. Read More

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http://Insights.ovid.com/crossref?an=00000478-201706000-0000
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http://dx.doi.org/10.1097/PAS.0000000000000830DOI Listing
June 2017
4 Reads

Response to anti-programmed cell death protein-1 antibodies in men treated for platinum refractory germ cell cancer relapsed after high-dose chemotherapy and stem cell transplantation.

Eur J Cancer 2017 05 4;76:1-7. Epub 2017 Mar 4.

Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany. Electronic address:

Introduction: Treatment options for patients with platinum refractory metastatic germ cell tumours (GCT) relapsing after high-dose chemotherapy and autologous stem cell transplantation are limited and survival is poor. Antibodies directed against programmed cell death protein-1 (PD-1) and programmed cell death ligand-1 (PD-L1) are currently assessed within clinical trials. We present updated data on our experience with checkpoint inhibitors as a compassionate use off-label treatment attempt for highly-pretreated patients with GCT and provide an overview of the current literature on PD-L1 expression in this rare tumour entity. Read More

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http://dx.doi.org/10.1016/j.ejca.2017.01.033DOI Listing
May 2017
7 Reads

Robot-assisted retroperitoneal lymph node dissection (RA-RPLND) in the adolescent population.

J Pediatr Urol 2017 Apr 17;13(2):223-224. Epub 2017 Feb 17.

Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:

Background: Robot-assisted retroperitoneal lymph node dissection (RA-RPLND) has built on success and techniques of laparoscopic RPLND, with the added benefits of robotic technology. This paper demonstrates use of the da Vinci Xi system for RA-RPLND in two adolescent patients.

Methods: Case #1: A 17-year-old male presented with a left testicular mass and elevated alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG). Read More

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http://dx.doi.org/10.1016/j.jpurol.2017.01.007DOI Listing
April 2017
2 Reads

Robot - assisted laparoscopic retroperitoneal lymph node dissection in testicular tumor.

Int Braz J Urol 2017 Jan-Feb;43(1):171

Instituto do Câncer do Estado de São Paulo (ICESP), SP, Brasil.

Introduction And Objective: Retroperitoneal lymph node dissection (RPLND) is indicated for patients with non-seminomatous germ cell tumor (NSGCT) with residual disease after chemotherapy. Although the gold standard approach is still the open surgery, few cases of robot-assisted laparoscopic RPLND have been described. Herein, we aim to present the surgical technique for robot-assisted laparoscopic RPLND. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293403PMC
http://dx.doi.org/10.1590/S1677-5538.IBJU.2015.0436DOI Listing
July 2017
5 Reads

Role of High-Dose Chemotherapy With Autologous Stem-Cell Rescue in Men With Previously Treated Germ Cell Tumors.

Authors:
Lance C Pagliaro

J Clin Oncol 2017 Apr 19;35(10):1036-1040. Epub 2016 Dec 19.

Lance C. Pagliaro, Mayo Clinic, Rochester, MN.

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. Read More

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http://dx.doi.org/10.1200/JCO.2016.70.6523DOI Listing
April 2017
7 Reads

Imprints and DPPA3 are bypassed during pluripotency- and differentiation-coupled methylation reprogramming in testicular germ cell tumors.

Genome Res 2016 11 20;26(11):1490-1504. Epub 2016 Oct 20.

Department of Pathology, Erasmus MC-University Medical Center, Rotterdam, 3015, The Netherlands.

Testicular germ cell tumors (TGCTs) share germline ancestry but diverge phenotypically and clinically as seminoma (SE) and nonseminoma (NSE), the latter including the pluripotent embryonal carcinoma (EC) and its differentiated derivatives, teratoma (TE), yolk sac tumor (YST), and choriocarcinoma. Epigenomes from TGCTs may illuminate reprogramming in both normal development and testicular tumorigenesis. Herein we investigate pure-histological forms of 130 TGCTs for conserved and subtype-specific DNA methylation, including analysis of relatedness to pluripotent stem cell (ESC, iPSC), primordial germ cell (PGC), and differentiated somatic references. Read More

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http://dx.doi.org/10.1101/gr.201293.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088592PMC
November 2016
14 Reads

The present and future of serum diagnostic tests for testicular germ cell tumours.

Nat Rev Urol 2016 12 18;13(12):715-725. Epub 2016 Oct 18.

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.

Testicular germ cell tumours (GCTs) are the most common malignancy occurring in young adult men and the incidence of these tumours is increasing. Current research priorities in this field include improving overall survival for patients classified as being 'poor-risk' and reducing late effects of treatment for patients classified as 'good-risk'. Testicular GCTs are broadly classified into seminomas and nonseminomatous GCTs (NSGCTs). Read More

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http://dx.doi.org/10.1038/nrurol.2016.170DOI Listing
December 2016
7 Reads

[Two Cases of Germ Cell Tumors with Hyperthyroidism Due to High Serum hCGLevels].

Hinyokika Kiyo 2016 Sep;62(9):489-493

The Department of Urology, The Department of Internal Medicine, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba.

We reported two cases of hyperthyroidism that developed during induction chemotherapy for advanced germ cell tumors with high serum human chorionic gonadotropin (hCG) levels. Case 1 : An 18-year-old man with mediastinal choriocarcinoma complained of tachycardia and tremor. His pretreatment serum hCG level was 1. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_62_9_489DOI Listing
September 2016
11 Reads

Pure Stage I Seminoma with an Elevated hCG of 25,265 mIU/ml: A Case Report.

Urol Case Rep 2016 Nov 30;9:48-50. Epub 2016 Sep 30.

Division of Urology, Sendai City Hospital, Sendai, Japan.

We report a histologically pure stage 1 seminoma with an elevated human chorionic gonadotropin (hCG). A 38 year-old man was referred for the evaluation of the left testicular swelling. He showed an elevated serum hCG level of 25,265 mIU/ml with normal a fetoprotein and lactate dehydrogenase. Read More

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http://dx.doi.org/10.1016/j.eucr.2016.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048077PMC
November 2016
6 Reads

Chemotherapy Used to Halt Lower GI Bleeding in a Rare Case of Metastatic Choriocarcinoma to the GI Tract.

Case Rep Oncol Med 2016 1;2016:7620205. Epub 2016 Sep 1.

Morehouse School of Medicine, Atlanta, GA 30310, USA.

Choriocarcinoma, a nonseminomatous germ cell tumor, is a rare type of testicular malignancy that tends to occur in young males. It is, however, exceedingly rare for choriocarcinoma to involve the GI tract. In this article, we present a rare case of a 31-year-old male, diagnosed with choriocarcinoma of the left testes, along with several metastases to distant sites. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023839PMC
http://dx.doi.org/10.1155/2016/7620205DOI Listing
October 2016
15 Reads

The clinical presentation and favorable prognosis of patients with isolated metachronous brain metastasis from germ cell tumors.

Jpn J Clin Oncol 2016 Aug 27. Epub 2016 Aug 27.

Department of Urology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

Objective: We conducted the present study to elucidate the clinical presentation, treatment outcomes and risk factors for the development of metachronous brain metastasis at a single progressive disease site, the so-called isolated brain metastasis, in patients with testicular germ cell tumors.

Methods: To identify metachronous brain metastasis in a timely manner, brain imaging was performed when the re-elevation of tumor markers was observed during chemotherapy, even in patients who were free from central nervous system symptoms. The medical records of 147 patients with metastatic germ cell tumors who were treated between 1991 and 2015 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1093/jjco/hyw116DOI Listing
August 2016
14 Reads

HMGA2 expression distinguishes between different types of postpubertal testicular germ cell tumour.

J Pathol Clin Res 2015 Oct 12;1(4):239-51. Epub 2015 Sep 12.

Center for Human GeneticsUniversity of Bremen BremenGermany; Institute for Medical Genetics, University of Rostock, University Medicine RostockGermany.

The group of postpubertal testicular germ cell tumours encompasses lesions with highly diverse differentiation - seminomas, embryonal carcinomas, yolk sac tumours, teratomas and choriocarcinomas. Heterogeneous differentiation is often present within individual tumours and the correct identification of the components is of clinical relevance. HMGA2 re-expression has been reported in many tumours, including testicular germ cell tumours. Read More

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http://dx.doi.org/10.1002/cjp2.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939894PMC
October 2015
2 Reads

[Diagnostic value of immunohistochemistry and FISH for chromosome 12p in type Ⅱ testicular germ cell tumors].

Zhonghua Nan Ke Xue 2016 Aug;22(8):692-697

Department of Pathology, Jinling Hospital, Nanjing University School of Medicine / Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.

Objective: To study the pathological morphology, immunohistochemical characteristics, and molecular changes of type Ⅱ testicular germ cell tumors (TGCT) and investigate the possible value of immunohistochemistry and fluorescence in situ hybridization (FISH) in the diagnosis of TGCT.

Methods: We collected for this study 97 cases of TGCT, including 75 cases of seminoma, 17 cases of embryonal carcinoma, 11 cases of yolk sac tumor, 16 cases of mature teratoma, 3 cases of immature teratoma, and 1 case of epidermoid cyst, in which normal testicular tissue was found in 20 and non-TGCT in 6. We detected the expressions of different antibodies in various subtypes of TGCT by immunohistochemistry and determined the rate of chromosome 12p abnormality using FISH. Read More

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August 2016
8 Reads

"Dissecting Gonadoblastoma" of Scully: A Morphologic Variant That Often Mimics Germinoma.

Am J Surg Pathol 2016 10;40(10):1417-23

*Department of Pathology, Stanford University School of Medicine, Stanford, CA †Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN ‡The James Homer Wright Pathology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Dr Robert E. Scully, who recognized and defined gonadoblastoma (GB), used the term "dissecting gonadoblastoma" (DGB) to describe variants with either an infiltrative type or diffuse pattern instead of the usual small nested arrangement. These patterns have not been emphasized in the literature. Read More

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http://dx.doi.org/10.1097/PAS.0000000000000704DOI Listing
October 2016
5 Reads

Pulmonary Metastatic Choriocarcinoma from a Burned-out Testicular Tumor.

Intern Med 2016 1;55(11):1481-5. Epub 2016 Jun 1.

Division of Respiratory Medicine, Matsue Red Cross Hospital, Japan.

A 54-year-old man was referred to our hospital because of progressive dyspnea. Chest computed tomography showed multiple nodular shadows with a peripheral ground-glass halo. His clinical condition continued to deteriorate with the development of progressive respiratory failure requiring mechanical ventilation. Read More

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http://dx.doi.org/10.2169/internalmedicine.55.5679DOI Listing
March 2017
8 Reads

New perspective on molecular markers as promising therapeutic targets in germ cell tumors.

Authors:
Paolo Chieffi

Intractable Rare Dis Res 2016 May;5(2):137-9

Dipartimento di Psicologia, Seconda Università di Napoli, Caserta, Italy.

Testicular germ cell tumors (TGCTs) are the most frequent solid malignant tumors in men 20-40 years of age and the most frequent cause of death from solid tumors in this age group. TGCTs comprise two major histologic groups: seminomas and non-seminomas germ cell tumors (NSGCTs). NSGCTs can be further divided into embryonal carcinoma, Teratoma, yolk sac tumor, and choriocarcinoma. Read More

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http://dx.doi.org/10.5582/irdr.2016.01007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869583PMC
May 2016
1 Read

Human Hemochromatosis Protein (HFE) Immunoperoxidase Stain Highlights Choriocarcinoma within Mixed Germ Cell Tumors.

Dis Markers 2016 13;2016:5236482. Epub 2016 Mar 13.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.

Identification of choriocarcinoma within a germ cell tumor can have major implications for the subsequent staging and treatment of testicular neoplasms. Immunoperoxidase staining greatly enhances the speed and sensitivity of identifying occult, though clinically significant, tumor components. In mixed germ cell tumors, staining for beta-human chorionic gonadotropin (β-hCG) has been historically used to assess for the presence and burden of choriocarcinoma. Read More

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http://dx.doi.org/10.1155/2016/5236482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808540PMC
December 2016
7 Reads

DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor.

Jpn J Clin Oncol 2016 May 24;46(5):475-81. Epub 2016 Feb 24.

Department of Urology, Faculty of Medicine, University of Tsukuba, Tsukuba.

Objective: DNA methyltransferase 3-like plays an important role in germ cell development. The aim of this study was to analyse the DNA methyltransferase 3-like protein expression in testicular germ cell tumors.

Methods: The immunohistochemical expression of DNA methyltransferase 3-like was examined in 86 testicular germ cell tumor specimens in various clinical settings. Read More

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http://dx.doi.org/10.1093/jjco/hyw012DOI Listing
May 2016
27 Reads

ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor.

Mod Pathol 2016 06 26;29(6):591-8. Epub 2016 Feb 26.

Department of Pathology, Mount Sinai Medical Center, New York, NY, USA.

Although the function of zinc finger and BTB domain containing 16 (ZBTB16) in spermatogenesis is well documented, expression of ZBTB16 in germ cell tumors has not yet been studied. The aim of this study was to investigate the immunohistochemical expression and diagnostic utility of ZBTB16 in germ cell tumors. A total of 67 adult germ cell tumors were studied (62 testicular germ cell tumors, 2 ovarian yolk sac tumors, 1 mediastinal yolk sac tumor, and 2 retroperitoneal metastatic yolk sac tumors). Read More

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http://dx.doi.org/10.1038/modpathol.2016.46DOI Listing
June 2016
18 Reads