1,259 results match your criteria Testicular Choriocarcinoma

An Exceptionally Rare Cause of Refractory Gastrointestinal Bleed: Choriocarcinoma Syndrome.

Cureus 2021 Apr 20;13(4):e14599. Epub 2021 Apr 20.

Gastroenterology and Hepatology, University of California San Francisco Fresno, Fresno, USA.

Testicular choriocarcinomas comprise less than 1% of all testicular tumors and are often highly vascular with early hematogenous metastasis. Choriocarcinoma syndrome (CS) is a rare entity distinguished by diffuse tumor burden and often fatal bleeding from metastatic sites. Most reported cases describe pulmonary hemorrhage secondary to initiation of chemotherapy. Read More

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Two new cases of testicular choriocarcinoma with cutaneous metastases.

Int J Dermatol 2021 May 17. Epub 2021 May 17.

Dermatology Department, Universidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Monterrey, Nuevo León, Mexico.

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Testicular Germ Cell Tumors: Paraneoplastic Syndromes and the Role of Beta-Human Chorionic Gonadotropin.

Cureus 2021 Apr 4;13(4):e14286. Epub 2021 Apr 4.

Division of Hematology and Oncology, University of California Irvine, Irvine, USA.

Choriocarcinoma syndrome is a rare phenomenon that occurs in male patients with testicular choriocarcinoma. Male patients who have a testicular non-seminomatous germ cell tumor (TNSGCT) with at least partial choriocarcinoma histology, and metastases to the lungs and/or other extragonadal sites, as well as a markedly elevated beta-human chorionic gonadotropin (HCG), have been prone to pulmonary bleeding, hypoxia, and acute respiratory distress syndrome (ARDS). The respiratory complications occur immediately after chemotherapy is administered or, in some cases, spontaneously. Read More

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Gastrointestinal Bleeding Secondary to Metastatic Duodenal Choriocarcinoma in a Patient with Concomitant Peptic Ulcer Disease.

Case Rep Gastrointest Med 2021 2;2021:6664147. Epub 2021 Mar 2.

Department of Gastroenterology, Staten Island University Hospital-Northwell Health, New York, NY, USA.

Testicular tumors are one of the most common solid tumors in young males. Choriocarcinoma usually presents as metastatic disease. Gastrointestinal tract involvement is rare. Read More

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Expression of programmed death ligand-1 (PD-L1) in metastatic and postchemotherapy viable testicular germ cell tumors.

Urol Oncol 2021 May 5;39(5):303.e1-303.e8. Epub 2021 Mar 5.

Department of Surgery, Faculty of Medicine, CHU de Québec-Université Laval. Electronic address:

Introduction: Chemotherapy for testicular germ cell tumors (GCT) is highly effective, with few patients who do not respond. Clinical studies to evaluated novel treatments are challenging given the rarity of these patients. Therefore, we sought to evaluate PD-L1 staining on metastatic and postchemotherapy viable testicular GCTs as a surrogate for potential benefit for immunotherapy targeting the PD-1/PD-L1 axis. Read More

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Prognostic Value of Apoptosis-Inducing Factor (AIF) in Germ Cell Tumors.

Cancers (Basel) 2021 Feb 13;13(4). Epub 2021 Feb 13.

Translational Research Unit, 2nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, 833 10 Bratislava, Slovakia.

Apoptosis is a strictly regulated process essential for preservation of tissue homeostasis. This study aimed to evaluate expression of apoptosis inducing factor (AIF) in testicular germ cell tumors (GCTs) and to correlate expression patterns with clinicopathological variables. Formalin-fixed and paraffin-embedded specimens of non-neoplastic testicular tissue and GCTs obtained from 216 patients were included in the study. Read More

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February 2021

Metastatic testicular choriocarcinoma presenting as eyelid swelling and ptosis.

Orbit 2021 Feb 25:1-4. Epub 2021 Feb 25.

Ophthalmology Department, University Hospitals of Leicester, Leicester, UK.

A 34-year-old man presented with an 8-day history of swelling and ptosis affecting the right upper eyelid. An MRI scan showed right superior rectus enlargement. Histology of an incisional biopsy of the muscle demonstrated metastatic choriocarcinoma to the orbit, positive for pan-cytokeratins, beta-HCG and GATA3. Read More

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February 2021

Metastatic testicular choriocarcinoma to the rectum requiring diverting colostomy.

ANZ J Surg 2021 Feb 24. Epub 2021 Feb 24.

Department of Urology, Westmead Hospital, Sydney, New South Wales, Australia.

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February 2021

Pure testicular choriocarcinoma Cannonball metastases as a presenting imaging feature: A case report and a review of literature.

Radiol Case Rep 2021 Apr 9;16(4):923-928. Epub 2021 Feb 9.

Healthpoint Medical Center, Amman, Jordan.

Pure testicular choriocarcinoma is an extremely rare subtype of nonseminomatous germ cell tumor, accounting for less than 1% of all germ cell tumors and only 0.19% of all testicular tumors. It is a highly aggressive malignant tumor with early multiorgan metastasis and poor prognosis. Read More

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F-FDG PET/CT Imaging of Metastatic Testicular Choriocarcinoma Mimicking Gastric Cancer which Initial Symptom is Melena

Mol Imaging Radionucl Ther 2021 02;30(1):47-49

Recep Tayyip Erdoğan University Faculty of Medicine, Department of Gastroenterology, Rize, Turkey.

Gastric metastasis of choriocarcinoma is rarely reported in the literature. This case report presents the case of multiple metastatic testicular choriocarcinoma mimicking gastric cancer, with melena as the initial symptom. In this case, fluorine-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) showed that the testis was the primary focus. Read More

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February 2021

Testicular germ cell tumors type 2 have high RNA expression of , the gene for lactate dehydrogenase subunit B.

Asian J Androl 2021 Feb 9. Epub 2021 Feb 9.

Department of Urology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

This study analyzed RNA expression of genes for three serum tumor markers, alpha fetoprotein (AFP), human chorionic gonadotropin (hCG), and lactate dehydrogenase (LDH), in patients with testicular germ cell tumors (TGCT) type 2. The gene AFP encodes AFP, the gene for chorionic gonadotropin beta polypeptide 5 (CGB5) encodes a major part of the specific beta subunit of hCG, and the genes for LDH subunit A (LDHA), LDH subunit B (LDHB), and LDH subunit C (LDHC) encode three different subunits of LDH. LDHB encodes the LDHB subunit present as a tetramer in LDH isoenzyme 1 (LDH-1). Read More

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February 2021

Clinicopathological characteristics and survival outcomes for testicular choriocarcinoma: a population-based study.

Transl Androl Urol 2021 Jan;10(1):408-416

Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Background: Due to the scarcity of cases of testicular choriocarcinoma (CC), its clinicopathological characteristics and prognosis have not been well summarized. Consequently, we conducted this population-based case-control study to characterize the features of testicular CC.

Methods: The SEER database was used to extract qualified data. Read More

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January 2021

[A Case of Extragonadal Germ Cell Tumor Treated by Induction Therapy with A Reduced Bep Regimen].

Hinyokika Kiyo 2020 Dec;66(12):449-452

The Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine.

A 21-year-old man with chief complaints of left hypochondriac and chest pain was shown to have multiple masses in the lung, a pleural effusion in the right cavum thoracis, a mediastinal mass, and lymphadenopathy detected by computed tomographic scan. He was diagnosed with an extragonadal germ cell tumor based on pathologic findings from lung biopsies and elevation of the serum total human chorionic gonadotropin. He underwent a reduced chemotherapy regimen consisting of bleomycin, cisplatin, and etoposide (reduced BEP) to lower the risk of acute respiratory distress syndrome (ARDS), a manifestation of choriocarcinoma syndrome, which occurs at induction chemotherapy with the full-dose BEP regimen. Read More

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December 2020

Genital exam, a missed piece of the puzzle in medical diagnosis, can be lifesaving in men: A lesson from a case of a state of shock due to duodenal metastasis of testicular choriocarcinoma.

Qatar Med J 2020 9;2020(2):31. Epub 2020 Nov 9.

Pediatrics Department, Fasa University of Medical Sciences, Iran.

Here we reported a case of a 17-year-old man with a history of weakness, vertigo, nausea, vomiting and dark stool within the last three months prior to admission. He was taken to the Emergency Room in a state of shock. After resuscitation, vital signs became stable, but due to low hemoglobin (HB = 5 g/dl), to find the source of bleeding, endoscopy was performed and a mass in the duodenum was detected. Read More

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November 2020

Successful treatment of a high-risk nonseminomatous germ cell tumor using etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine: A case report.

World J Clin Cases 2020 Nov;8(21):5334-5340

Department of Internal Medicine, Division of Hematology-Oncology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University School of Medicine, Bucheon 14584, South Korea.

Background: Choriocarcinoma is an infrequent entity and the most aggressive subtype of germ-cell tumors. Because of early metastatic spread and rapid disease progression, choriocarcinoma patients display poor prognosis. Although etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine (EMA-CO) regimen is widely used to treat gestational trophoblastic tumors in females, its role in treating male choriocarcinoma is seldom reported. Read More

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November 2020

In Search of TGCT Biomarkers: A Comprehensive and Histopathological Analysis.

Dis Markers 2020 6;2020:8841880. Epub 2020 Nov 6.

Department of Medical Biology, University of Zagreb School of Medicine, Šalata 3, 10000 Zagreb, Croatia.

Testicular germ cell tumors (TGCTs) are ever more affecting the young male population. Germ cell neoplasia (GCNIS) is the origin of TGCTs, namely, seminomas (SE) and a heterogeneous group of nonseminomas (NS) comprising embryonal carcinoma, teratoma, yolk sac tumor, and choriocarcinoma. Response to the treatment and prognosis, especially of NS, depend on precise diagnosis with a necessity for discovery of new biomarkers. Read More

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November 2020

Thyroid Storm Associated with Testicular Choriocarcinoma.

Eur J Case Rep Intern Med 2020 2;7(10):001754. Epub 2020 Jul 2.

Faculty of Medicine, Universidad Autónoma de Coahuila, Saltillo, Coahuila, Mexico.

Thyroid storm is a rare, life-threatening condition that can be caused by various pathologies including serious conditions associated with human chorionic gonadotropin (hCG)-producing tumours. We present the case of a 17-year-old male patient with a 1-month history of dyspnoea and a 3-day history of palpitations and fever. General examination revealed a left testicular mass. Read More

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Rare Tumours of the Testis: Twelve Years of Experience.

Prague Med Rep 2020 ;121(3):181-193

Department of Medical Oncology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.

Rare tumours of the testis includes a wide variety of tumours. We aim to present clinical and histological characteristics of our patients with rare tumours of the testis. The medical records of 33 patients who were treated and followed-up for testicular rare tumours in our center between 2007 and 2020 were retrospectively reviewed. Read More

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December 2020

Detection of Circulating Tumor Cells (CTCs) in Patients with Testicular Germ Cell Tumors.

Methods Mol Biol 2021 ;2195:245-261

Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

While the majority of patients with advanced testicular germ cell tumors (GCT) achieve complete responses after chemotherapy and if indicated after postchemotherapy resection of residual lesions, about 20% of patients have incomplete responses or show relapses. Moreover, toxicity of chemotherapy is high, and severe adverse chronic effects have been described. Therefore, there is an urgent need for biomarkers that could help to improve tumor staging, and support decision-making, ideally including monitoring of therapy response and prediction of relapse. Read More

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Cultivation of Testicular Germ Cell Cancer Cell Lines and Establishment of Gene-Edited Subclones Using CRISPR/Cas9.

Methods Mol Biol 2021 ;2195:85-97

Department of Developmental Pathology, Institute of Pathology, University Hospital Bonn, Bonn, Germany.

Type II testicular germ cell tumors (GCTs) can be classified as seminoma or embryonal carcinoma. Both subtypes present distinct cellular morphologies and characteristics. Seminomas closely resemble primordial germ cells (PGCs) with respect to their transcriptome and epigenetic signature (DNA hypomethylation). Read More

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A Unique Case of Orthostasis in a Patient with Testicular Choriocarcinoma.

JACC CardioOncol 2019 Dec 17;1(2):326-330. Epub 2019 Dec 17.

Cardio-Oncology Center of Excellence, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO.

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December 2019

Germline Sequencing Identifies Rare Variants in Finnish Subjects with Familial Germ Cell Tumors.

Appl Clin Genet 2020 30;13:127-137. Epub 2020 Jun 30.

Department of Pediatrics, Division of Hematology and Oncology, Washington University School of Medicine, St. Louis, MO, USA.

Purpose: Pediatric germ cell tumors are rare, representing about 3% of childhood malignancies in children less than 15 years of age, presenting in neonates or adolescents with a greater incidence noted in older adolescents. Aberrations in primordial germ cell proliferation/differentiation can lead to a variety of neoplasms, including teratomas, embryonal carcinoma, choriocarcinoma, and yolk sac tumors.

Patients And Methods: Three Finnish families with varying familial germ cell tumors were identified, and whole-genome sequencing was performed using an Illumina sequencing platform. Read More

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Testicular Mixed Germ Cell Tumor Combined with Malignant Transformation to Chondrosarcoma: A Very Rare and Aggressive Disease.

Am J Case Rep 2020 Jun 26;21:e922933. Epub 2020 Jun 26.

Department of Internal Medicine, Umm Alqura University, Makkah, Saudi Arabia.

BACKGROUND Testicular mixed germ cell tumors (GCTs) represent a spectrum of malignancies that differ in terms of histopathology, clinical complications, and overall outcome. A variety of aggressive combinations containing different histological types have been described among such testicular tumors. However, a histopathology characterized by a combination of teratoma and choriocarcinoma, as seen in this case, in which the teratomatous component shows a secondary transformation to chondrosarcoma, is considered very rare. Read More

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HNF1β is a sensitive and specific novel marker for yolk sac tumor: a tissue microarray analysis of 601 testicular germ cell tumors.

Mod Pathol 2020 11 19;33(11):2354-2360. Epub 2020 Jun 19.

Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.

Hepatocyte Nuclear Factor 1 beta (HNF1β) is a transcription factor which plays an important role during early organogenesis, especially of the pancreato-biliary and urogenital tract. Furthermore, HNF1β is an established marker in the differential diagnosis of ovarian cancer and shows a distinct nuclear expression in the clear cell carcinoma subtype. Recently, it has been described in yolk sac tumor, which represents a common component in many non-seminomatous germ cell tumors. Read More

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November 2020

Cystic Trophoblastic Tumor in a Primary Central Nervous System Post-Chemotherapy Germ Cell Tumor: The First Case Report.

Int J Surg Pathol 2020 Dec 4;28(8):925-928. Epub 2020 Jun 4.

2971Henry Ford Health System, Henry Ford Hospital, Detroit, MI, USA.

Cystic trophoblastic tumor (CTT) is an uncommon trophoblastic proliferation of germ cell tumor origin, mostly reported in post-chemotherapy metastases of testicular germ cell tumors and rarely primary untreated testicular tumors. To date, we are not aware of occurrence in a non-testicular tumor. A 12-year-old boy presented with limb swelling, increased appetite, weight gain, and precocious puberty. Read More

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December 2020

Postchemotherapy retroperitoneal lymph node dissection in patients presenting with very high HCG levels.

Urol Oncol 2020 08 21;38(8):687.e19-687.e23. Epub 2020 May 21.

Indiana University School of Medicine, Indianapolis, IN.

Purpose: Choriocarcinoma germ cell tumors are rare and usually present with significantly elevated human chorionic gonadotropin (hCG) levels. When curable, it is felt to be largely a result of chemotherapy. We sought to determine the histologic characteristics for those undergoing postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) and compare them with metastatic nonseminomatous germ cell tumor (NSGCT) patients with similarly elevated hCG levels. Read More

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Giant testicular tumour with major choriocarcinoma component.

Urol Case Rep 2020 Sep 30;32:101234. Epub 2020 Apr 30.

Dubbo Base Hospital, Myall St, Dubbo, NSW, Australia.

Giant testicular tumour, with volume greater than 10 times a normal testicle, is a rare presentation of testicular cancer. This is of particular note in nations where public health campaigns and high literacy rates generally lead to early detection and cure. We present a 22 year old male, with 14 month history of increasing scrotal swelling. Read More

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September 2020