1,235 results match your criteria Testicular Choriocarcinoma


Testicular Mixed Germ Cell Tumor Combined with Malignant Transformation to Chondrosarcoma: A Very Rare and Aggressive Disease.

Am J Case Rep 2020 Jun 26;21:e922933. Epub 2020 Jun 26.

Department of Internal Medicine, Umm Alqura University, Makkah, Saudi Arabia.

BACKGROUND Testicular mixed germ cell tumors (GCTs) represent a spectrum of malignancies that differ in terms of histopathology, clinical complications, and overall outcome. A variety of aggressive combinations containing different histological types have been described among such testicular tumors. However, a histopathology characterized by a combination of teratoma and choriocarcinoma, as seen in this case, in which the teratomatous component shows a secondary transformation to chondrosarcoma, is considered very rare. Read More

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http://dx.doi.org/10.12659/AJCR.922933DOI Listing

HNF1β is a sensitive and specific novel marker for yolk sac tumor: a tissue microarray analysis of 601 testicular germ cell tumors.

Mod Pathol 2020 Jun 19. Epub 2020 Jun 19.

Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.

Hepatocyte Nuclear Factor 1 beta (HNF1β) is a transcription factor which plays an important role during early organogenesis, especially of the pancreato-biliary and urogenital tract. Furthermore, HNF1β is an established marker in the differential diagnosis of ovarian cancer and shows a distinct nuclear expression in the clear cell carcinoma subtype. Recently, it has been described in yolk sac tumor, which represents a common component in many non-seminomatous germ cell tumors. Read More

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http://dx.doi.org/10.1038/s41379-020-0597-xDOI Listing

Cystic Trophoblastic Tumor in a Primary Central Nervous System Post-Chemotherapy Germ Cell Tumor: The First Case Report.

Int J Surg Pathol 2020 Jun 4:1066896920929751. Epub 2020 Jun 4.

Henry Ford Health System, Henry Ford Hospital, Detroit, MI, USA.

Cystic trophoblastic tumor (CTT) is an uncommon trophoblastic proliferation of germ cell tumor origin, mostly reported in post-chemotherapy metastases of testicular germ cell tumors and rarely primary untreated testicular tumors. To date, we are not aware of occurrence in a non-testicular tumor. A 12-year-old boy presented with limb swelling, increased appetite, weight gain, and precocious puberty. Read More

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http://dx.doi.org/10.1177/1066896920929751DOI Listing
June 2020
0.961 Impact Factor

Postchemotherapy retroperitoneal lymph node dissection in patients presenting with very high HCG levels.

Urol Oncol 2020 May 21. Epub 2020 May 21.

Indiana University School of Medicine, Indianapolis, IN.

Purpose: Choriocarcinoma germ cell tumors are rare and usually present with significantly elevated human chorionic gonadotropin (hCG) levels. When curable, it is felt to be largely a result of chemotherapy. We sought to determine the histologic characteristics for those undergoing postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) and compare them with metastatic nonseminomatous germ cell tumor (NSGCT) patients with similarly elevated hCG levels. Read More

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http://dx.doi.org/10.1016/j.urolonc.2020.04.024DOI Listing

Giant testicular tumour with major choriocarcinoma component.

Urol Case Rep 2020 Sep 30;32:101234. Epub 2020 Apr 30.

Dubbo Base Hospital, Myall St, Dubbo, NSW, Australia.

Giant testicular tumour, with volume greater than 10 times a normal testicle, is a rare presentation of testicular cancer. This is of particular note in nations where public health campaigns and high literacy rates generally lead to early detection and cure. We present a 22 year old male, with 14 month history of increasing scrotal swelling. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217984PMC
September 2020

Report From the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers: IV: Current and Future Utilization of Molecular-Genetic Tests for Testicular Germ Cell Tumors.

Am J Surg Pathol 2020 Jul;44(7):e66-e79

Pathology, Indiana University School of Medicine, Indianapolis, IN.

The International Society of Urological Pathology (ISUP) organized a Consultation Conference in March 2019 dealing with applications of molecular pathology in Urogenital Pathology, including testicular tumors (with a focus on germ cell tumors [GCTs]), preceded by a survey among its members to get insight into current practices in testicular germ cell tumor (TGCT) diagnostics and adoption of the ISUP immunohistochemical guidelines published in 2014. On the basis of the premeeting survey, the most commonly used immunomarker panel includes OCT3/4, placental alkaline phosphate, D2-40, SALL4, CD117, and CD30 for GCTs and the documentation of germ cell neoplasia in situ (GCNIS). Molecular testing, specifically 12p copy gain, is informative to distinguish non-GCNIS versus GCNIS related GCTs, and establishing germ cell origin of tumors both in the context of primary and metastatic lesions. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289140PMC
July 2020
5.145 Impact Factor

Head and neck cutaneous metastasis of testicular choriocarcinoma.

BMJ Case Rep 2020 Feb 25;13(2). Epub 2020 Feb 25.

Department of Otolaryngology-Head and Neck Surgery, USF Health Morsani College of Medicine, Tampa, Florida, USA.

Testicular choriocarcinoma (CC) is a malignant germ cell tumour which most frequently presents with disseminated metastasis, often involving the lungs, brain and liver. Metastatic are characterised by extensive vascularity, often causing patients to present emergently with potentially life-threatening haemorrhagic complications. We report a patient with disseminated testicular CC, presenting with haemorrhage from a dermal metastatic focus involving the lower lip and mentum, requiring surgical intervention. Read More

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http://dx.doi.org/10.1136/bcr-2019-233337DOI Listing
February 2020

Frequent EGFR expression/EGFR amplification and lack of activating mutation in testicular choriocarcinoma.

Pathol Int 2020 May 29;70(5):262-269. Epub 2020 Jan 29.

Department of Basic Pathology, National Defense Medical College, Saitama, Japan.

Choriocarcinoma (CC) is the rarest but most aggressive histological component of adult testicular germ cell tumor (TGCT). Although we previously reported a putative role of epidermal growth factor receptor (EGFR) alterations in the progression of CC, little is known about the kinase-activating mutation status of EGFR, which predicts the response to EGFR-tyrosine kinase inhibitors. In this study, we clinicopathologically reviewed a total of 12 cases of mixed TGCTs with CC components. Read More

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http://dx.doi.org/10.1111/pin.12905DOI Listing

Differences in PD-L1-Expressing Macrophages and Immune Microenvironment in Testicular Germ Cell Tumors.

Am J Clin Pathol 2020 02;153(3):387-395

Department of Anatomic Pathology, Hospital of the University of Pennsylvania, Philadelphia.

Objectives: To characterize the tumor microenvironment of testicular germ cell tumors (GCTs) using immunohistochemical markers.

Methods: Seventy-seven orchiectomies, including 36 nonmetastatic (NM) seminomas, 15 metastatic (M) seminomas, 13 nonmetastatic nonseminomatous germ cell tumors (NSGCTs), and 13 metastatic NSGCTs, were studied with PD-1, PD-L1, FOXP3, CD68, CD163, and mismatch repair (MMR) immunohistochemistry. FOXP3+ and PD-1+ tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) expressing CD68 and CD163 were enumerated. Read More

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http://dx.doi.org/10.1093/ajcp/aqz184DOI Listing
February 2020

[Hyperthyroidism as a diagnostic key to advanced choriocarcinoma. An unusual association].

Medicina (B Aires) 2019 ;79(5):411-414

Servicio de Clínica Médica, Sanatorio San José, Buenos Aires, Argentina. E-mail:

Hyperthyroidism is a relatively frequent condition with multiple causes. The most common cause is Graves' disease; followed by hyperthyroid multinodular goiter and toxic adenoma. Association between hyperthyroidism and cancer is infrequent in daily practice. Read More

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December 2019
1 Read

Bilateral wunderlich syndrome secondary to synchronous bilateral testicular germ cell tumor. A case report.

Urol Case Rep 2020 Jan 24;28:101028. Epub 2019 Sep 24.

Department of Pathology, Oncology Hospital, Mexican Institute of Social Security, Mexico City, Mexico.

Testicular cancer accounts for 1% of male neoplasms, the most common histology is bilateral presentation is reported in 1-2% of cases, and germ cell tumor histology represents 90-95% of cases. Especifically, choriocarcinoma as a pure component represents 0.3-1% of these neoplasms and as a mixed component, 8%. Read More

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http://dx.doi.org/10.1016/j.eucr.2019.101028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796737PMC
January 2020

Detailed Characterization of Immune Cell Infiltrate and Expression of Immune Checkpoint Molecules PD-L1/CTLA-4 and MMR Proteins in Testicular Germ Cell Tumors Disclose Novel Disease Biomarkers.

Cancers (Basel) 2019 Oct 11;11(10). Epub 2019 Oct 11.

Department of Pathology, Portuguese Oncology Institute of Porto (IPOP), R. Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal.

The immune infiltrate plays an important part in testicular germ cell tumors, but it remains scarcely studied. We aimed at thoroughly characterizing the immune infiltrate and expression of immune checkpoints PD-L1/CTLA-4 and mismatch repair (MMR) proteins in these neoplasms, seeking for associations with patient outcome. A total of 162 consecutively diagnosed patients (2005-2018) were included. Read More

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http://dx.doi.org/10.3390/cancers11101535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826711PMC
October 2019
1 Read

Testicular Vein Sampling Can Reveal Gonadotropin-Independent Unilateral Steroidogenesis Supporting Spermatogenesis.

J Endocr Soc 2019 Oct 30;3(10):1881-1886. Epub 2019 Jul 30.

Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium.

Suppressed gonadotropins combined with high-normal serum testosterone concentrations in oligozoospermic men suggest either use of exogenous testosterone or presence of a testosterone-producing tumor. We describe the case of a 31-year-old man referred for primary infertility. Gonadotropins were undetectably low, but testosterone and estradiol were in the high-normal range. Read More

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http://dx.doi.org/10.1210/js.2019-00180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773433PMC
October 2019
1 Read

Metastatic Testicular Choriocarcinoma: An Unusual Cause of Upper Gastrointestinal Bleed.

Cureus 2019 Jul 26;11(7):e5243. Epub 2019 Jul 26.

Gastroenterology, Ascension Saint John Hospital, Detroit, USA.

Testicular cancer is the most common neoplasia in men between the ages of 15 to 44 years. Choriocarcinoma represents less than 2% of testicular tumors. It is usually characterized by an early hematogenous spread to the lungs and brain. Read More

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http://dx.doi.org/10.7759/cureus.5243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759043PMC
July 2019
1 Read

Wnt suppressor and stem cell regulator TCF7L1 is a sensitive immunohistochemical marker to differentiate testicular seminoma from non-seminomatous germ cell tumor.

Exp Mol Pathol 2019 10 2;110:104293. Epub 2019 Aug 2.

Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, United States of America; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, United States of America; Lillehei Heart Institute and Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, United States of America. Electronic address:

The accurate classification and proper identification of testicular germ cell tumors is imperative for treatment selection and clinical prognosis. Although such distinction can often be achieved by microscopic morphology alone, ancillary tests may at times be needed. T-cell factor 7 L1 (TCF7L1, also known as TCF3), a component of the Wnt signaling pathway, plays important roles in embryonic stem cell self-renewal and lineage specification. Read More

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http://dx.doi.org/10.1016/j.yexmp.2019.104293DOI Listing
October 2019
7 Reads
2.706 Impact Factor

Current Management of Disseminated Germ Cell Tumors.

Urol Clin North Am 2019 Aug 21;46(3):377-388. Epub 2019 May 21.

Division of Medical Oncology, Department of Medicine, BC Cancer--Vancouver Cancer Center, University of British Columbia, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada. Electronic address:

The modern treatment of disseminated germ cell tumors (GCT) relies largely on cisplatin-based regimens, particularly combination chemotherapy with bleomycin, etoposide, and cisplatin. This article reviews the evidence supporting its use as well as common alterations based on prognostic grouping or contraindications to bleomycin. Special topics around the management of intermediate/poor prognosis choriocarcinoma and brain metastases are included. Read More

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http://dx.doi.org/10.1016/j.ucl.2019.04.003DOI Listing
August 2019
6 Reads

An up-date on novel molecular targets in testicular germ cell tumors subtypes.

Authors:
Paolo Chieffi

Intractable Rare Dis Res 2019 May;8(2):161-164

Dipartimento di Psicologia, Università della Campania, Caserta, Italy.

Testicular germ cell tumors (TGCTs) are the most frequent solid malignant tumors in men 20-34 years of age and the most frequent cause of death from solid tumors in this age group. In addition, the incidence of these tumors has significantly increased over the last few decades. Testicular germ cell tumors are classified into seminoma and nonseminoma germ cell tumors (NSGCTs). Read More

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http://dx.doi.org/10.5582/irdr.2019.01055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557231PMC
May 2019
7 Reads

TCam-2 Cells Deficient for SOX2 and FOXA2 Are Blocked in Differentiation and Maintain a Seminoma-Like Cell Fate In Vivo.

Cancers (Basel) 2019 May 25;11(5). Epub 2019 May 25.

Department of Developmental Pathology, Institute of Pathology, Bonn University Medical School, 53127 Bonn, Germany.

Testicular germ cell tumors (GCTs) are very common in young men and can be stratified into seminomas and non-seminomas. While seminomas share a similar gene expression and epigenetic profile with primordial germ cells, the stem cell population of the non-seminomas, the embryonal carcinoma (EC), resembles malignant embryonic stem cells. Thus, ECs are able to differentiate into cells of all three germ layers (teratomas) and even extra-embryonic-tissue-like cells (yolk-sac tumor, choriocarcinoma). Read More

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https://www.mdpi.com/2072-6694/11/5/728
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http://dx.doi.org/10.3390/cancers11050728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562827PMC
May 2019
13 Reads

Malignant epidural spinal cord compression secondary to testicular cancer (mixed choriocarcinoma and seminoma) in the immediate post radical orchidectomy period.

Clin Case Rep 2019 May 2;7(5):955-959. Epub 2019 Apr 2.

Anatomical Pathology Department, Chris Hani Baragwanath Academic Hospital University of the Witwatersrand Soweto South Africa.

Acute spinal cord compression in the immediate postoperative period from a possible choriocarcinoma syndrome (CCS) on hemorrhagic epidural spinal metastasis has never been described before and needs to be promptly recognized and managed. A low hemoglobin associated with choriocarcinoma should raise suspicion of this syndrome. Read More

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http://dx.doi.org/10.1002/ccr3.2131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509927PMC
May 2019
12 Reads

Severe Complications in Testicular Germ Cell Tumors: The Choriocarcinoma Syndrome.

Front Endocrinol (Lausanne) 2019 12;10:218. Epub 2019 Apr 12.

2nd Department of Oncology, Faculty of Medicine, National Cancer Institute, Comenius University, Bratislava, Slovakia.

Testicular germ cell tumors (TGCTs) represent the most common solid tumor in young men and is a model of curable cancer. The effectiveness of cisplatin-based chemotherapy secures more than 95% of patients' 5-years survival rate. However, some high-risk patients with a very advanced disease develop choriocarcinoma syndrome (CS) connected with acute respiratory failure with poor prognosis and high mortality rate shortly after beginning systemic chemotherapy. Read More

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http://dx.doi.org/10.3389/fendo.2019.00218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474390PMC
April 2019
9 Reads

Choriocarcinoma Syndrome: A Potentially Fatal Complication of Testicular Cancer.

Case Rep Oncol Med 2019 24;2019:4092941. Epub 2019 Feb 24.

Creighton University Arizona Health Education Alliance, Department of Hematology and Oncology, USA.

Choriocarcinoma syndrome is a rare clinical entity with advanced, high volume choriocarcinomatous tumors and markedly elevated B-hCG (>50,000 IU/L). Recognition is important because the diagnosis of this syndrome identifies poor prognosis without mortality-proven management options. We present a case of a male in his twenties with metastatic choriocarcinoma who developed choriocarcinoma syndrome acutely after chemotherapy commencement. Read More

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https://www.hindawi.com/journals/crionm/2019/4092941/
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http://dx.doi.org/10.1155/2019/4092941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409012PMC
February 2019
8 Reads

[Testicular germ cell tumors: Histopathological and molecular features].

Bull Cancer 2019 Apr 21;106(4):328-341. Epub 2019 Mar 21.

Hôpital Foch, service d'anatomie et cytologie pathologiques, 40, rue Worth, 92150 Suresnes, France; Institut Curie, service de pathologie, 35, rue Dailly, 92240 Saint Cloud, France. Electronic address:

In 2016, the WHO classification of testicular germ cell tumors was revised considering advances in the understanding of their tumorigenesis and molecular features. This restructuring led to a division into two major groups with, on one hand, prepubertal-type tumors, not derived from germ cell neoplasia in situ (GCNIS), and on the other hand, postpubertal-type tumors, GCNIS-derived, which occur in youg men (seminoma and non seminomatous germ cell tumors - embryonal carcinoma, yolk sac tumor, teratoma and choriocarcinoma essentially). The term germ cell neoplasia in situ is consensually accepted as a new terminology for the precursor lesion. Read More

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http://dx.doi.org/10.1016/j.bulcan.2019.02.004DOI Listing
April 2019
8 Reads

Recent advances in the regulation of testicular germ cell tumors by microRNAs.

Front Biosci (Landmark Ed) 2019 03 1;24:765-776. Epub 2019 Mar 1.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

Testicular germ cell tumors (TGCTs) are generally rare but represent the most common solid tumors in young men. They are classified broadly into seminoma, which resemble primordial germ cells (PGCs), and non-seminoma, which are either undifferentiated (embryonic carcinoma) or differentiated (teratoma, yolk sac tumor, choriocarcinomas) patterning. A widespread role for microRNAs (miRNAs), in diverse molecular processes driving initiation and progression of various types of TGCTs has been recently studied. Read More

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March 2019
17 Reads

Acute pulmonary hemorrhage associated with metastatic testicular choriocarcinoma in a 46-year-old incarcerated male.

Urol Ann 2019 Jan-Mar;11(1):109-112

Department of Urology, Hahnemann University Hospital, Philadelphia, Pennsylvania, USA.

Pure testicular choriocarcinoma is a rare histological subtype of germ cell tumor (GCT) and typically presents with distant metastases and aggressive features leading to a generally poor prognosis. Unique to choriocarcinoma among GCT histological subtypes is the propensity of spontaneous hemorrhage into metastatic lesions. We report a case of pure testicular choriocarcinoma in a 46-year-old male with postoperative acute pulmonary hemorrhage secondary to tumor invasion of the lungs, and the subsequent management of his disease with a discussion of relevant literature. Read More

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http://dx.doi.org/10.4103/UA.UA_51_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362783PMC
February 2019
11 Reads

New Anti-Cancer Strategies in Testicular Germ Cell Tumors.

Recent Pat Anticancer Drug Discov 2019 ;14(1):53-59

Institute of Endocrinology and Experimental Oncology of the CNR c / o Department of Molecular Medicine and Medical Biotechnology, School of Medicine and Surgery of Naples, University of Naples 'Federico II', Naples, Italy.

Background: The most common solid malignancy of young men aged 20 to 34 years is testicular germ cell tumor. In addition, the incidence of these tumors has significantly increased throughout the last years. Testicular germ cell tumors are classified into seminoma and nonseminoma germ cell tumors, which take in yolk sac tumor, embryonal cell carcinoma, choriocarcinoma, and teratoma. Read More

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http://www.eurekaselect.com/168893/article
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http://dx.doi.org/10.2174/1574892814666190111120023DOI Listing
December 2019
46 Reads

Choriocarcinoma Syndrome as an Initial Presentation of Testicular Cancer.

Case Rep Oncol Med 2018 8;2018:8065615. Epub 2018 Nov 8.

Centro Universitario Contra el Cáncer, University Hospital "Dr. José Eleuterio González" and Faculty of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.

Choriocarcinoma syndrome (CS) is a rare clinical entity within the spectrum of nonseminomatous germ-cell tumors (NSGCT). It is characterized by the abrupt establishment of rapidly progressive and hemorrhagic tumors associated with very high levels of the beta fraction of human chorionic gonadotropin (-hCG) and with a very poor prognosis, particularly in patients with -hCG values above 50,000 IU/L. We present the case of a 17-year-old man with a sudden onset nonmassive hemoptysis. Read More

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http://dx.doi.org/10.1155/2018/8065615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249998PMC
November 2018
30 Reads

[Diagnosis and treatment of testicular mixed germ cell tumors: A report of 27 cases].

Zhonghua Nan Ke Xue 2018 Nov;24(11):987-991

Department of Urology, The First Hospital Affiliated to Nanhua University, Hengyang, Hunan 421001, China.

Objective: To investigate the clinical features, diagnosis, treatment and prognosis of testicular mixed germ cell tumors (TMGCT).

Methods: This retrospective study included 27 cases (2 children and 25 adults) of TMGCT confirmed surgically and pathologically in our hospital from December 2007 to December 2012. The patients' ranged in the age of onset from 7 months to 63 years, averaging at 29. Read More

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November 2018

Testicular Choriocarcinoma Metastasizing to the Small Bowel Causing Intussusception: Case Report.

J Gastrointest Cancer 2019 Dec;50(4):1005-1008

Pathology Department, Texas Tech Health and Science Center, El Paso, TX, USA.

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http://dx.doi.org/10.1007/s12029-018-0172-6DOI Listing
December 2019
8 Reads

Cytokeratin 7, inhibin, and p63 in testicular germ cell tumor: superior markers of choriocarcinoma compared to β-human chorionic gonadotropin.

Hum Pathol 2019 02 22;84:254-261. Epub 2018 Oct 22.

Department of Pathology, The Ohio State University Medical Center, Columbus, OH 43210, USA. Electronic address:

Choriocarcinoma can be difficult to differentiate from other subtypes of testicular germ cell tumor and can occur unexpectedly in a distant, late metastasis. The aim of this investigation was to identify a marker superior to β-human chorionic gonadotropin (β-hCG) for choriocarcinoma. Sixty-two primary and metastatic testicular germ cell tumors (27 choriocarcinomas, 19 yolk sac tumors, 29 embryonal carcinomas, 28 seminomas, 22 teratomas, 3 epithelioid trophoblastic tumors [ETTs]) were analyzed for immunohistochemical expression of cytokeratin 7 (CK7), inhibin, p63, and β-hCG. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183039
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http://dx.doi.org/10.1016/j.humpath.2018.10.007DOI Listing
February 2019
89 Reads
2.770 Impact Factor

Pure Testicular Choriocarcinoma with Dermatological, Brain, and Gastrointestinal Metastases.

Cureus 2018 Aug 1;10(8):e3083. Epub 2018 Aug 1.

Department of Internal Medicine, Dell Seton Medical Center at The University of Texas, Austin, USA.

Testicular choriocarcinoma is a non-seminomatous germ cell tumor (NSGCT) and is the rarest of all testicular cancers. Nearly all choriocarcinomas can be classified as either pure choriocarcinoma or as a component of a mixed germ cell tumor. Pure testicular choriocarcinoma is extremely aggressive and metastasizes early and extensively. Read More

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https://www.cureus.com/articles/13842-pure-testicular-chorio
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http://dx.doi.org/10.7759/cureus.3083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168053PMC
August 2018
7 Reads

Successful management of a patient with radiological presentation of choriocarcinoma syndrome before induction chemotherapy.

J Cancer Res Ther 2018 Sep;14(Supplement):S803-S805

Department of Urology and Andrology, Graduate School of Medicine, Kansai Medical University, Osaka, Japan.

Choriocarcinoma syndrome is a life-threatening lysis syndrome caused by blood vessel rupture and subsequent tumor bleeding. We describe a case of pretreatment choriocarcinoma syndrome that developed in a 27-year-old man. He underwent a high orchiectomy at a local hospital and was diagnosed with metastatic testicular tumor given the high serum human chorionic gonadotropin levels (943,601 mIU/mL). Read More

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http://www.cancerjournal.net/text.asp?2018/14/10/803/175433
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http://dx.doi.org/10.4103/0973-1482.175433DOI Listing
September 2018
49 Reads

c-MET receptor as potential biomarker and target molecule for malignant testicular germ cell tumors.

Oncotarget 2018 Aug 7;9(61):31842-31860. Epub 2018 Aug 7.

Department of Anatomy, Histology, Forensic-Medicine and Orthopaedics, "Sapienza" University of Rome, Italy.

Type II testicular germ cell tumors (TGCTs) represent the most frequent malignancy in Caucasian males (20-40 years). Even if diagnosed with disseminated disease, >80% of patients are cured; however, a small percentage of cases progress and result in death. It is commonly accepted that these cancers arise from a disturbed testicular embryonic niche that leads to the block of gonocyte differentiation. Read More

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http://www.oncotarget.com/fulltext/25867
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http://dx.doi.org/10.18632/oncotarget.25867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112764PMC
August 2018
24 Reads

Pure testicular choriocarcinoma presenting as a friable hemorrhagic nodule on the lip.

JAAD Case Rep 2018 Aug 15;4(7):705-707. Epub 2018 Aug 15.

Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah.

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http://dx.doi.org/10.1016/j.jdcr.2018.05.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098204PMC
August 2018
5 Reads

Chemotherapy for metastatic testicular cancer: The first nationwide multi-institutional study by the Cancer Registration Committee of the Japanese Urological Association.

Int J Urol 2018 08 17;25(8):730-736. Epub 2018 Jul 17.

Department of Urology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Objectives: To assess clinicopathological data and oncological outcomes focused on metastatic testicular cancer patients, who received chemotherapy as the initial treatment, in the nationwide multi-institutional study by the Cancer Registration Committee of the Japanese Urological Association.

Methods: A testicular cancer survey was carried out by the Japanese Urological Association in 2011 to register newly diagnosed testicular cancers in 2005 and 2008. Among 1121 registered patients, 278 patients with metastases who received chemotherapy as the initial treatment and could be categorized by the Japanese Urological Association classification were eligible for the analysis. Read More

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http://dx.doi.org/10.1111/iju.13720DOI Listing
August 2018
16 Reads

Dose-reduced first cycle of chemotherapy for prevention of life-threatening acute complications in nonseminomatous germ cell tumor patients with ultra high tumor markers and/or poor performance status.

J Cancer Res Clin Oncol 2018 Sep 5;144(9):1817-1823. Epub 2018 Jul 5.

Department of Clinical Pharmacology and Chemotherapy, N.N. Blokhin Russian Cancer Research Center, 24 Kashirskoye sh., Moscow, 115478, Russia.

Purpose: Patients with metastatic nonseminomatous germ cell tumors (mNSGCT) and a high tumor burden or a poor performance status at initial diagnosis are at risk from potentially life-threatening early complications during or after the first chemotherapy cycle. The outcomes with dose-reduced first cycle of chemotherapy in this population of patients are not well established.

Methods: We performed a retrospective analysis of patients with mNSGCT and International Germ Cell Cancer Collaborative Group (IGCCCG) poor risk features. Read More

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http://dx.doi.org/10.1007/s00432-018-2695-4DOI Listing
September 2018
94 Reads

Cutaneous Metastasis of Choriocarcinoma in 2 Male Patients: A Rare Presentation of an Aggressive Malignancy That Dermatopathologists Must Recognize.

Am J Dermatopathol 2019 Jan;41(1):50-54

Dartmouth Geisel School of Medicine, Hanover, NH.

Testicular choriocarcinoma needs to be considered in the differential diagnosis of cutaneous metastases in young adult men because of its propensity for early hematogenous dissemination. Furthermore, the diagnosis may not be suspected in many cases in which there is clinically no testicular enlargement. This highly aggressive germ cell tumor typically metastasizes to the liver, lungs, and brain. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001209DOI Listing
January 2019
10 Reads

Cutaneous and systematic metastasis of testicular choriocarcinoma: Case report and literature review.

Medicine (Baltimore) 2018 Jun;97(22):e10736

Department of Urology, the First Affiliated Hospital of GuangXi Medical University.

Rationale: Cutaneous metastasis of testicular choriocarcinoma is exceptionally uncommon. To our knowledge, only 14 cases have been reported in the past 10 years in the pubmed. We have an uncommon case of testicular choriocarcinoma who has metastasized to the adjacent skin and organ systems. Read More

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http://dx.doi.org/10.1097/MD.0000000000010736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392768PMC
June 2018
39 Reads

Identification of Glypican-3 (GPC3) Expression in a Lethal Subgroup of Refractory Cisplatin-Resistant Testicular Germ-Cell Tumors.

Clin Genitourin Cancer 2018 10 26;16(5):325-327. Epub 2018 May 26.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2018.05.004DOI Listing
October 2018
13 Reads

The Clinical Significance of a Small Component of Choriocarcinoma in Testicular Mixed Germ Cell Tumor (MGCT).

Am J Surg Pathol 2018 08;42(8):1113-1120

The Johns Hopkins Medical Institutions, Baltimore, MD.

The clinical significance of limited choriocarcinoma in a malignant mixed germ cell tumor (MGCT) is unknown. Men with a MGCT with ≤5% choriocarcinoma at radical orchiectomy (RO) between 2000 and 2016 from our consult service were studied. Of 50 men in our cohort, we had clinical information for 30 men. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001088DOI Listing
August 2018
36 Reads

Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors.

Hum Pathol 2018 11 16;81:26-36. Epub 2018 May 16.

Division of Clinical Pathology, Geneva University Hospitals, 1205 Geneva, Switzerland.

Identification of the yolk sac tumor (YST) component in germ cell tumors (GCT) may prove challenging, and highly sensitive and specific immunohistochemical markers are still lacking. Preliminary data from the literature suggest that HNF1β may represent a sensitive marker of YST. The specificity of HNF1β has not been addressed in GCT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183015
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http://dx.doi.org/10.1016/j.humpath.2018.04.025DOI Listing
November 2018
24 Reads

Spontaneous renal hemorrhage secondary to choriocarcinoma in a man with congenital hypospadias and cryptorchidism: a case report and literature review.

BMC Cancer 2018 May 8;18(1):543. Epub 2018 May 8.

University College London Medical School, Medical School Building, 74 Huntley Street, London, WC1E 6BT, England, UK.

Background: Choriocarcinoma is a rare malignant germ-cell tumour, most commonly found in adult women. It infrequently presents as spontaneous renal haemorrhage (SRH). Genital malformation and SRH secondary to choriocarcinoma has previously been only reported in females. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-4424-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941373PMC
May 2018
34 Reads

Testicular choriocarcinoma with cutaneous metastasis in a 19-year-old man.

J Cutan Pathol 2018 Jul 16;45(7):535-538. Epub 2018 May 16.

Department of Medical Oncology, National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany.

A 19-year-old man suffering from testicular choriocarcinoma presented to the dermatology department with a cutaneous metastasis on his head. This metastasis was the first sign of disease that led to medical consultation. Histopathology revealed cytotrophoblasts and syncytiotrophoblasts, the later expressing human chorionic gonadotropin antigen. Read More

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http://dx.doi.org/10.1111/cup.13261DOI Listing
July 2018
7 Reads

EGF Receptor and mTORC1 Are Novel Therapeutic Targets in Nonseminomatous Germ Cell Tumors.

Mol Cancer Ther 2018 05 26;17(5):1079-1089. Epub 2018 Feb 26.

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.

Germ cell tumors (GCT) are malignant tumors that arise from pluripotent embryonic germ cells and occur in children and young adults. GCTs are treated with cisplatin-based regimens which, while overall effective, fail to cure all patients and cause significant adverse late effects. The seminoma and nonseminoma forms of GCT exhibit distinct differentiation states, clinical behavior, and response to treatment; however, the molecular mechanisms of GCT differentiation are not fully understood. Read More

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932259PMC
May 2018
18 Reads

Onco-testicular sperm extraction (Onco-TESE) from a single testis with metachronous bilateral testicular cancer: a case report.

Basic Clin Androl 2018 25;28. Epub 2018 Jan 25.

1Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562 Japan.

Background: Although oncologic testicular sperm extraction (onco-TESE) has been increasingly practiced, the evidence of onco-TESE performed in patients with testicular cancer is insufficient. Furthermore, in bilateral testicular cancer, accounting for 0.5%-1% of testicular cancers, onco-TESE is more challenging and has been insufficiently reported. Read More

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http://dx.doi.org/10.1186/s12610-018-0066-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785797PMC
January 2018
64 Reads

Placental Site Trophoblastic Tumor in Nonseminomatous Mixed Germ Cell Tumors of the Testis: a Case Report and Review of the Literature.

Clin Genitourin Cancer 2018 04 27;16(2):e349-e354. Epub 2017 Dec 27.

Service de Pathologie, Hôpital Saint-Louis, AP-HP, Paris, France; Service de Recherches en Hémato-immunologie, CEA, Hôpital Saint-Louis, Paris, France; Université Paris Diderot, UMR E_5, Institut Universitaire d'Hématologie, Paris, France; Université Paris Diderot, Inserm, UMR_S1165, Institut Universitaire d'Hématologie, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2017.12.010DOI Listing
April 2018
10 Reads

Detailed pathologic analysis on the co-occurrence of non-seminomatous germ cell tumor subtypes in matched orchiectomy and retroperitoneal lymph node dissections.

Med Oncol 2018 Jan 31;35(3):21. Epub 2018 Jan 31.

Department of Pathology, University of Michigan Health System, Ann Arbor, MI, USA.

The frequency of co-occurrence between germ cell tumor (GCT) components in non-seminomatous germ cell tumor (NSGCT) orchiectomy specimens and their correlation with histologic findings in subsequent retroperitoneal lymph node dissection (RPLND) specimens have not been well characterized. The objective of the study was to report the first detailed clinicopathologic analysis of NSGCT orchiectomy and RPLND samples to determine the likelihood and agreement of the co-occurrence of GCT components. A total of 118 consecutive patients with NSGCT treated between 1988 and 2012 who underwent both orchiectomy and RPLND at a single academic tertiary care center were analyzed. Read More

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http://dx.doi.org/10.1007/s12032-018-1090-yDOI Listing
January 2018
27 Reads

Early outcomes and patterns of failure following proton therapy for nonmetastatic intracranial nongerminomatous germ cell tumors.

Pediatr Blood Cancer 2018 06 30;65(6):e26997. Epub 2018 Jan 30.

Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, Florida.

Background: Although dosimetric comparisons demonstrate the advantage of proton therapy (PT) over conventional radiotherapy for nongerminomatous germ cell tumors (NGGCT), clinical outcome data for this rare tumor are lacking. We sought to evaluate outcomes for children with NGGCT treated with PT.

Methods: Between 2007 and 2016, 14 children (median age 11, range, 5-19 years) with nonmetastatic NGGCT were treated with PT after induction chemotherapy. Read More

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http://dx.doi.org/10.1002/pbc.26997DOI Listing
June 2018
24 Reads

[Primary mediastinal choriocarcinoma: A case report and literature review].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017 Oct;42(10):1222-1227

Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Primary mediastinal choriocarcinoma in male is not a very common disease, with nonspecific clinical manifestations. Gynecomastia and testicular atrophy are present in some cases. The levels of serum human chorionic gonadotropin are often significantly increased. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2017.10.016DOI Listing
October 2017
11 Reads