1,283 results match your criteria Testicular Choriocarcinoma


Gastrointestinal bleeding caused by metastatic testicular choriocarcinoma: a case report and literature review.

World J Surg Oncol 2022 Jun 16;20(1):205. Epub 2022 Jun 16.

Department of Gastroenterology and Hepatology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Background: Testicular tumor is one of the common solid tumors in young men. Testicular choriocarcinoma is a non-spermatogonial germ cell tumor, which is the rarest of all testicular cancers. Choriocarcinoma usually shows bleeding at the metastatic site, while gastrointestinal involvement is rare. Read More

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Severe thyrotoxicosis as initial presentation of gastric choriocarcinoma: a case report.

J Med Case Rep 2022 Apr 21;16(1):159. Epub 2022 Apr 21.

Department of Surgical and Molecular Pathology, American British Cowdray Medical Center, Mexico City, Mexico.

Background: Extragonadal choriocarcinoma is rare and can be associated with hyperthyroidism when producing very high levels of human chorionic gonadotropin.

Case Presentation: A 62-year-old Hispanic female presented with a 3-week history of shortness of breath, palpitations, extreme weakness, new-onset hot flashes, and right flank pain. Her physical examination was remarkable for tachycardia, hepatomegaly, hyperreflexia, and tremor; goiter was absent. Read More

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Testicular Germ Cell Tumor Composed of Seminoma and Teratoma Metastasizing as Choriocarcinoma to the Lung Successfully Treated With Salvage Chemotherapy and Bone-Marrow Transplant: A Case Report.

Cureus 2022 Mar 6;14(3):e22885. Epub 2022 Mar 6.

Hematology and Medical Oncology, HCA Houston Healthcare Kingwood Medical Center, Kingwood, USA.

A 25-year-old male presented to our hospital with two months of progressively worsening left arm swelling, intermittent left-sided chest pressure, and a painless right testicular mass. CT of the chest, abdomen, and pelvis revealed a large mediastinal mass, multiple lung nodules, and several large right testicular nodules. The patient underwent a CT-guided biopsy of his right lung nodule, followed by a radical right inguinal orchiectomy. Read More

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Differential expression of preferentially expressed antigen in melanoma (PRAME) in testicular germ cell tumors - A comparative study with SOX17.

Exp Mol Pathol 2022 Jun 4;126:104761. Epub 2022 Apr 4.

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:

The accurate identification of different components in testicular germ cell tumors (GCT) is essential for tailoring treatment and informing the clinical prognosis. PRAME (preferentially expressed antigen in melanoma), a member in the family of cancer testis antigens, plays critical roles in regulating pluripotency and suppressing somatic/germ cell differentiation in seminomas (SEM). To investigate the potential diagnostic value of PRAME in testicular GCT, here we comparatively examined the expression patterns of PRAME and SOX17 by immunohistochemistry in both pure and mixed GCT. Read More

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Pretreatment of choriocarcinoma syndrome: a rare complication of metastatic germ cell tumours.

BMJ Case Rep 2022 Mar 2;15(3). Epub 2022 Mar 2.

Urology, Western Health, Footscray, Victoria, Australia.

A 27-year-old man newly diagnosed with metastatic testicular choriocarcinoma developed a large right perinephric haematoma secondary to a metastatic deposit in his right kidney. His presentation was also complicated by bilateral iliac venous thrombosis and pulmonary embolism identified prior to initiation of chemotherapy. He underwent multiple attempts at angioembolisation of the bleeding vessels and ultimately angioembolisation of the main renal artery had to be performed to control the bleeding. Read More

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The core four - A panel of immunohistochemistry markers to diagnose and subtype testicular germ cell tumors.

Urol Ann 2022 Jan-Mar;14(1):21-26. Epub 2021 Dec 28.

Department of Pathology and Lab Medicine, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.

Context: Immunohistochemistry (IHC) to differentiate germ cell tumors.

Aims: The aim of the study is to differentiate seminomatous and nonseminomatous germ cell tumors (GCTs) with morphological overlap using a minimal and affordable panel of IHC markers.

Settings And Design: This is a retrospective observational study. Read More

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December 2021

Metastasis of Testicular Choriocarcinoma in the Stomach, Complicated by the Development of Choriocarcinoma Syndrome.

Case Rep Gastroenterol 2021 Sep-Dec;15(3):954-959. Epub 2021 Nov 25.

Department of Faculty Therapy No. 2, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.

Choriocarcinoma (CC) is a very rare and aggressive neoplasm. The characteristic feature of this disease is a rapid hematogenous spread, mainly to the lungs and brain, which largely defines clinical signs of the disease and complicates the diagnosis. Gastrointestinal metastases are rare, and of those, only few cases with gastric location have been reported. Read More

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November 2021

A 26-year old young male with severe anemia.

Respir Med Case Rep 2022 5;36:101575. Epub 2022 Jan 5.

Department of Pulmonary and Critical Care Medicine, Ozarks Medical Center, West Plains, Missouri, USA.

Testicular choriocarcinoma is a subset of Non-Seminomatous Germ Cell Tumors (NSGT) which is considered the rarest and most aggressive testicular cancer. It primarily affects males between the ages of 25-30 years. Unlike other testicular neoplasms that carry a cure rate of 95%, choriocarcinoma has significantly lower rate of cure. Read More

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January 2022

Choriocarcinoma Syndrome: A Rare and Serious Complication of Testicular Germ Cell Tumors.

Cureus 2021 Oct 11;13(10):e18681. Epub 2021 Oct 11.

Oncology, ProMedica Toledo Hospital, Toledo, USA.

Choriocarcinoma syndrome is a rare complication of metastatic germ cell tumors. The hallmark of the condition is metastatic tumor hemorrhage. We describe the case of a 28-year-old man with metastatic testicular choriocarcinoma who presented with dyspnea on exertion and lightheadedness. Read More

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October 2021

Small bowel metastases from a testicular choriocarcinoma revealed by gastrointestinal bleeding: a case report.

Pan Afr Med J 2021 20;39:259. Epub 2021 Aug 20.

Department of Gastroenterology, Mohamed VI University Hospital, Marrakech, Morocco.

Testicular germ cell tumors are the most common cancers in young men. In most cases, patients may present a painless testicular swelling. However, in 10% the presentation is variable and related to site of metastasis and complications. Read More

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November 2021

12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.

Neuro Oncol 2022 May;24(5):834-846

Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.

Background: Central nervous system (CNS) germ cell tumors (GCTs) are neoplasms predominantly arising in pediatric and young adult populations. While germinomas generally respond to chemotherapy and radiation, non-germinomatous GCTs (NGGCTs) require more intensive treatment. This study aimed to determine whether 12p gain could predict the prognosis of CNS GCTs. Read More

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A Rare Diagnosis with Poor Prognosis: Primary Gastric Choriocarcinoma.

Am J Med Sci 2022 03 19;363(3):e27-e28. Epub 2021 Oct 19.

Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA. Electronic address:

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[Successful Management for Refractory Non-Seminomatous Testicular Cancer with Retroperitoneal Lymph Node, Liver, Lung and Brain Metastases : A Case Report].

Hinyokika Kiyo 2021 Sep;67(9):433-437

The Department of Urology, Kumamoto University, School of Medicine.

An 18-year-old male was aware of painless left testicular enlargement. Contrast-enhanced computed tomography showed a retroperitoneal tumor, multiple liver tumors, and multiple lung tumors. A left testicular tumor was suspected, and left inguinal orchiectomy was performed. Read More

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September 2021

Thyroid storm as an early presentation of hCG-producing metastatic choriocarcinoma: a case report and review of the literature.

BMJ Case Rep 2021 Sep 27;14(9). Epub 2021 Sep 27.

MedStar Georgetown University Hospital, Washington, DC, USA.

Human chorionic gonadotropin (hCG)-induced hyperthyroidism has been previously reported as a rare paraneoplastic syndrome in non-seminomatous germ cell tumours and usually presents with mild symptoms or subclinical thyrotoxicosis. We present a case of a young adult man who consulted with abdominal pain, nausea and emesis. On admission, he was found to be tachycardic, febrile, anxious and with icteric sclera and tenderness to palpation in the right upper abdomen. Read More

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September 2021

Malignant Gonadal Germ Cell Tumors (Other Than Pure Germinoma) in Patients With Disorders of Sex Development: A Report of 21 Cases Based Largely on the Collection of Dr Robert E. Scully, Illustrating a High Frequency of Yolk Sac Tumor With Prominent Hepatoid and Glandular Features.

Am J Surg Pathol 2022 05;46(5):664-676

Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.

We describe 21 nonpure germinomatous gonadal germ cell tumors (9 with a germinoma component), all but 1 associated with gonadoblastoma, in patients with disorders of sex development who ranged from 7 to 36 years old (average, 20 y). Twenty patients were clinically described as phenotypic females with ambiguous genitalia/virilization and primary amenorrhea. The most common documented peripheral karyotype was 46,XY (10/12; 83%). Read More

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Choriocarcinoma metastatic to the skin: A rare occurrence associated with dismal outcome.

Rare Tumors 2021 20;13:20363613211039724. Epub 2021 Aug 20.

Department of Pathology and Laboratory Medicine, King Hussein Cancer Center, Amman, Amman Governorate, Jordan.

Germ cell tumors (GCTs) are a histologically heterogeneous group of tumors that arise from the primitive germ cell of the embryonic gonad. Choriocarcinoma is a variant of GCTs that is prone to hematogenous metastasis to the liver, lung, and brain. Cutaneous metastasis in choriocarcinoma is rarely encountered with only a few cases reported in literature. Read More

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Choriocarcinoma syndrome: A rare presentation of testicular germ cell tumour.

J Pak Med Assoc 2021 Aug;71(8):2090-2092

Department of Pediatric Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan.

Germ cell tumours (GCT) are the most common malignancy in men between the ages of 15 and 35 years. Pure choriocarcinoma is a very rare entity of non- seminomatous germ cell tumour and comprises only 1% -3% of all the testicular tumours. Choriocarcinoma syndrome is a clinical condition in which haemorrhage occurs from the metastatic sites with elevated level of the Beta-Human Chorionic gonadotropin (Beta -HCG). Read More

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Peripheral precocious puberty in a girl with an intracranial hCG-producing tumor: case report and literature review.

Endocr J 2021 Dec 17;68(12):1463-1467. Epub 2021 Jul 17.

Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.

Human chorionic gonadotropin (hCG)-producing tumors cause peripheral precocious puberty (PP) in boys, but generally not in girls. Homology between LH and hCG activates the LH receptor in testicular Leydig cells, increases testosterone production, and causes virilization. However, since FSH action is required for follicle development, hCG action alone does not increase estradiol (E2) production and does not cause feminization. Read More

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December 2021

A 20-Year-Old-Man With New Onset of Melena.

Gastroenterology 2022 Jan 17;162(1):e14-e15. Epub 2021 Jun 17.

Université de Montréal, Montréal, Québec, Canada; Division of Gastroenterology, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada. Electronic address:

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January 2022

Primary Mediastinal Nonseminomas: A Population-Based Surveillance, Epidemiology, and End Results Analysis.

J Surg Res 2021 11 11;267:25-36. Epub 2021 Jun 11.

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, Sichuan University, Chengdu, China. Electronic address:

Background: This study aimed to determine the disease characteristics and prognosis of patients with primary mediastinal nonseminomas (PMNS) in a Surveillance, Epidemiology, and End Results (SEER) analysis.

Materials And Methods: Demographic, treatment, and survival outcome data of cases with PMNS from 1975 to 2016 were retrieved. Cases with unknown variables mentioned in the analysis were excluded. Read More

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November 2021

An Exceptionally Rare Cause of Refractory Gastrointestinal Bleed: Choriocarcinoma Syndrome.

Cureus 2021 Apr 20;13(4):e14599. Epub 2021 Apr 20.

Gastroenterology and Hepatology, University of California San Francisco Fresno, Fresno, USA.

Testicular choriocarcinomas comprise less than 1% of all testicular tumors and are often highly vascular with early hematogenous metastasis. Choriocarcinoma syndrome (CS) is a rare entity distinguished by diffuse tumor burden and often fatal bleeding from metastatic sites. Most reported cases describe pulmonary hemorrhage secondary to initiation of chemotherapy. Read More

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Two new cases of testicular choriocarcinoma with cutaneous metastases.

Int J Dermatol 2022 Jan 17;61(1):e10-e13. Epub 2021 May 17.

Dermatology Department, Universidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Monterrey, Nuevo León, Mexico.

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January 2022

Testicular Germ Cell Tumors: Paraneoplastic Syndromes and the Role of Beta-Human Chorionic Gonadotropin.

Cureus 2021 Apr 4;13(4):e14286. Epub 2021 Apr 4.

Division of Hematology and Oncology, University of California Irvine, Irvine, USA.

Choriocarcinoma syndrome is a rare phenomenon that occurs in male patients with testicular choriocarcinoma. Male patients who have a testicular non-seminomatous germ cell tumor (TNSGCT) with at least partial choriocarcinoma histology, and metastases to the lungs and/or other extragonadal sites, as well as a markedly elevated beta-human chorionic gonadotropin (HCG), have been prone to pulmonary bleeding, hypoxia, and acute respiratory distress syndrome (ARDS). The respiratory complications occur immediately after chemotherapy is administered or, in some cases, spontaneously. Read More

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Gastrointestinal Bleeding Secondary to Metastatic Duodenal Choriocarcinoma in a Patient with Concomitant Peptic Ulcer Disease.

Case Rep Gastrointest Med 2021 2;2021:6664147. Epub 2021 Mar 2.

Department of Gastroenterology, Staten Island University Hospital-Northwell Health, New York, NY, USA.

Testicular tumors are one of the most common solid tumors in young males. Choriocarcinoma usually presents as metastatic disease. Gastrointestinal tract involvement is rare. Read More

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Expression of programmed death ligand-1 (PD-L1) in metastatic and postchemotherapy viable testicular germ cell tumors.

Urol Oncol 2021 05 5;39(5):303.e1-303.e8. Epub 2021 Mar 5.

Department of Surgery, Faculty of Medicine, CHU de Québec-Université Laval. Electronic address:

Introduction: Chemotherapy for testicular germ cell tumors (GCT) is highly effective, with few patients who do not respond. Clinical studies to evaluated novel treatments are challenging given the rarity of these patients. Therefore, we sought to evaluate PD-L1 staining on metastatic and postchemotherapy viable testicular GCTs as a surrogate for potential benefit for immunotherapy targeting the PD-1/PD-L1 axis. Read More

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Prognostic Value of Apoptosis-Inducing Factor (AIF) in Germ Cell Tumors.

Cancers (Basel) 2021 Feb 13;13(4). Epub 2021 Feb 13.

Translational Research Unit, 2nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, 833 10 Bratislava, Slovakia.

Apoptosis is a strictly regulated process essential for preservation of tissue homeostasis. This study aimed to evaluate expression of apoptosis inducing factor (AIF) in testicular germ cell tumors (GCTs) and to correlate expression patterns with clinicopathological variables. Formalin-fixed and paraffin-embedded specimens of non-neoplastic testicular tissue and GCTs obtained from 216 patients were included in the study. Read More

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February 2021

Metastatic testicular choriocarcinoma presenting as eyelid swelling and ptosis.

Orbit 2021 Feb 25:1-4. Epub 2021 Feb 25.

Ophthalmology Department, University Hospitals of Leicester, Leicester, UK.

A 34-year-old man presented with an 8-day history of swelling and ptosis affecting the right upper eyelid. An MRI scan showed right superior rectus enlargement. Histology of an incisional biopsy of the muscle demonstrated metastatic choriocarcinoma to the orbit, positive for pan-cytokeratins, beta-HCG and GATA3. Read More

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February 2021

Metastatic testicular choriocarcinoma to the rectum requiring diverting colostomy.

ANZ J Surg 2021 09 24;91(9):1936-1938. Epub 2021 Feb 24.

Department of Urology, Westmead Hospital, Sydney, New South Wales, Australia.

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September 2021

Pure testicular choriocarcinoma Cannonball metastases as a presenting imaging feature: A case report and a review of literature.

Radiol Case Rep 2021 Apr 9;16(4):923-928. Epub 2021 Feb 9.

Healthpoint Medical Center, Amman, Jordan.

Pure testicular choriocarcinoma is an extremely rare subtype of nonseminomatous germ cell tumor, accounting for less than 1% of all germ cell tumors and only 0.19% of all testicular tumors. It is a highly aggressive malignant tumor with early multiorgan metastasis and poor prognosis. Read More

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