72,652 results match your criteria Testicular Cancer


Testicular versus ejaculated spermatozoa for ICSI in patients without azoospermia: A systematic review.

Reprod Biomed Online 2018 Nov 6;37(5):573-580. Epub 2018 Oct 6.

Unit for Human Reproduction, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki Thessaloniki, Greece. Electronic address:

The use of testicular spermatozoa in men without azoospermia has been proposed as a means to increase the chances of pregnancy following assisted reproductive treatment. The purpose of this systematic review is to assess whether clinical outcomes are better when testicular rather than ejaculated spermatozoa are used for intracytoplasmic sperm injection in patients with abnormal semen parameters without azoospermia. A literature search identified four eligible studies out of 757 initially found. Read More

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November 2018

Serum tumor markers and testicular germ cell tumors: a primer for radiologists.

Abdom Radiol (NY) 2018 Dec 11. Epub 2018 Dec 11.

University Hospitals Cleveland Medical Center, 11100 Euclid Ave, Cleveland, OH, 44106, USA.

Serum tumor markers (STMs) play a critical role in the diagnosis, staging and follow-up of both seminomatous and nonseminomatous testicular germ cell neoplasms. Levels of alpha-fetoprotein (AFP), human chorionic gonadotropin (HCG), and lactate dehydrogenase (LDH), especially those measured after orchiectomy, also have implications for patient prognosis. Given that testicular germ cell tumors represent the most common solid tumor in men aged 20-34, radiologists must have familiarity with the clinical utilization and implications of these STMs. Read More

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December 2018
1 Read

Relapse in children with clinical stage I testicular yolk sac tumors after initial orchiectomy.

Pediatr Surg Int 2018 Dec 11. Epub 2018 Dec 11.

State Key Laboratory of Oncology in South China, Department of Urology, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, Guangdong, China.

Purpose: To evaluate risk factors of relapse in pediatric patients with clinical stage I (CS1) testicular yolk sac tumors.

Methods: With retrospective analysis, the medical records of children with pure testicular yolk sac tumors who were referred to Sun Yat-sen University Cancer Center and The First Affiliated Hospital from January 1995 to December 2015 were selected and recorded. Histopathology and staging were retrieved and multivariate analysis was performed with SPSS 20. Read More

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December 2018
1 Read

Artificial Neural Network to Predict Varicocele Impact on Male Fertility through Testicular Endocannabinoid Gene Expression Profiles.

Biomed Res Int 2018 13;2018:3591086. Epub 2018 Nov 13.

Faculty of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.

The relationship between varicocele and fertility has always been a matter of debate because of the absence of predictive clinical indicators or molecular markers able to define the severity of this disease. Even though accumulated evidence demonstrated that the endocannabinoid system (ECS) plays a central role in male reproductive biology, particularly in the testicular compartment, to date no data point to a role for ECS in the etiopathogenesis of varicocele. Therefore, the present research has been designed to investigate the relationship between testicular ECS gene expression and fertility, using a validated animal model of experimental varicocele (VAR), taking advantage of traditional statistical approaches and artificial neural network (ANN). Read More

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November 2018
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Novel method of histopathological analysis after testicular sperm extraction in patients with nonobstructive and obstructive azoospermia.

Clin Exp Reprod Med 2018 Dec 30;45(4):170-176. Epub 2018 Nov 30.

Department of Urology, Careggi Hospital, University of Florence, Florence, Italy.

Objective: To assess whether the "testicular pool" could be used for histological analysis and whether it gave more accurate information than the standard testicular biopsy.

Methods: Between January 2017 and March 2018, this single-center prospective study included 60 azoospermic men undergoing conventional bilateral testicular sperm extraction. Six samples were excised from each testicle and transferred to an embryologist. Read More

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December 2018

Testicular Rupture or Testicular Fracture? A Case Report and Literature Review.

Case Rep Urol 2018 14;2018:1323780. Epub 2018 Nov 14.

Department of Urology, St George's Hospital, London, UK.

Testicular trauma is relatively uncommon. However, severe injuries can result in many complications and should be carefully diagnosed and managed. We present a case of testicular fracture diagnosis made by ultrasonography. Read More

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November 2018
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Two cases of acute myocardial infarction during combined chemotherapy in young patients with testicular cancer.

J Cardiol Cases 2013 Jun 18;7(6):e176-e180. Epub 2013 Mar 18.

Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 2-50-1 Kuramoto-cho, Tokushima 770-8503, Japan.

The two patients were males aged over 30 years. To treat testicular tumors, combination chemotherapy with bleomycin, etoposide, and cisplatin (BEP) had been employed. In case 1, during the 4th course of BEP therapy, thoracic pain suddenly appeared. Read More

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June 2013
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The importance of multimodality cardiac imaging: Echocardiography and cardiovascular magnetic resonance imaging contributions to the diagnosis and management of a right ventricular mass.

J Cardiol Cases 2012 Oct 4;6(4):e109-e111. Epub 2012 Jul 4.

Hospital Santo António, Centro Hospitalar do Porto, Porto 4099-001, Portugal.

Cardiac metastases from testicular tumors are rare. We report a case of a 42-year-old man with a cardiac mass incidentally found in a computed tomography-scan included in the workup for lumbago and a suspicious neoformation in the right testicle. Transthoracic echocardiography showed a large multilobular ill-defined mass infiltrating the right ventricle free wall, protruding to, and partially obstructing the right ventricular outflow tract resulting in considerable outflow obstruction. Read More

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October 2012

Protective effects of Astragalin on spermatogenesis in streptozotocin-induced diabetes in male mice by improving antioxidant activity and inhibiting inflammation.

Biomed Pharmacother 2018 Dec 7;110:561-570. Epub 2018 Dec 7.

Department of Pharmacology, Ningxia Medical University, Yinchuan, 750004, China; Ningxia Hui Medicine Modern Engineering Research Center and Collaborative Innovation Center, Ningxia Medical University, Yinchuan, 750004, China. Electronic address:

Spermatogenic dysfunction is a common complication in men with diabetes and is the most important manifestation of diabetes-related male reproduction damage. Astragalin (AG) is one of the main flavonoids from Cuscuta chinensis, which has rich pharmacological activities. This study aimed to establish whether AG may contribute to the recovery from spermatogenic dysfunction. Read More

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December 2018

Clinical utility of plasma miR-371a-3p in germ cell tumors.

J Cell Mol Med 2018 Dec 7. Epub 2018 Dec 7.

Department of Pathology, Laboratory for Experimental Patho-Oncology, Erasmus MC University Medical Center, Cancer Institute, Rotterdam, The Netherlands.

Germ cell tumours predominantly of the testis ((T)GCTs) are remarkably chemotherapy sensitive. However, a small proportion of patients fail to be cured with cisplatin-based combination chemotherapy. miR-371a-3p is a new liquid biopsy biomarker for (T)GCTs. Read More

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December 2018

Menadione perturbs oxidative stress biomarkers and testicular function indices of rats.

J Biochem Mol Toxicol 2018 Dec 10:e22282. Epub 2018 Dec 10.

Antioxidants, Redox Biology, and Toxicology Research Laboratory, Department of Medical Biochemistry, College of Health Sciences, Nile University of Nigeria, FCT-Abuja, Nigeria.

In this study, we evaluated the influence of menadione on the androgenic, oxidative stress biomarkers, and testicular function indices in rats. Rats (20) were randomized into four groups (A-D) of five rats each. Rats in groups A, B, C, and D received the vehicle of administration (olive oil), 25, 50, or 100 mg/kg body weight menadione intraperitoneally, respectively, for 7 days. Read More

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December 2018

Choriocarcinoma Syndrome as an Initial Presentation of Testicular Cancer.

Case Rep Oncol Med 2018 8;2018:8065615. Epub 2018 Nov 8.

Centro Universitario Contra el Cáncer, University Hospital "Dr. José Eleuterio González" and Faculty of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.

Choriocarcinoma syndrome (CS) is a rare clinical entity within the spectrum of nonseminomatous germ-cell tumors (NSGCT). It is characterized by the abrupt establishment of rapidly progressive and hemorrhagic tumors associated with very high levels of the beta fraction of human chorionic gonadotropin (-hCG) and with a very poor prognosis, particularly in patients with -hCG values above 50,000 IU/L. We present the case of a 17-year-old man with a sudden onset nonmassive hemoptysis. Read More

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November 2018

Testicular Germ Cell Tumors: A Cytogenomic Update.

J Assoc Genet Technol 2018 ;44(4):128-133

The International Circle of Genetic Studies, Los Angeles, CA.

Objectives: Testicular germ cell tumors (TGCT) are a rare neoplasia but are still the most common malignancy in males between the ages of 15 and 44. TGCTs can be divided into two main types: Seminomas (SE) and non-seminomas (NS), the latter with an earlier age of onset and a worst prognosis. One of the most consistent features of TGCTs is the gain of material in the short arm of chromosome 12, that occurs in almost 100% of TGCT cases; 80% of them involve the formation of an isochromosome of the short arm i(12p). Read More

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January 2018

The autosomal Gsdf gene plays a role in male gonad development in Chinese tongue sole (Cynoglossus semilaevis).

Sci Rep 2018 Dec 7;8(1):17716. Epub 2018 Dec 7.

Key Lab of Sustainable Development of Marine Fisheries, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, 266071, China.

Gsdf is a key gene for testicular differentiation in teleost. However, little is known about the function of Gsdf in Chinese tongue sole (Cynoglossus semilaevis). In this study, we obtained the full-length Gsdf gene (CS-Gsdf), and functional characterization revealed its potential participation during germ cell differentiation in testes. Read More

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December 2018
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Inhibin B: are modified ranges needed for orchiectomised testicular cancer patients?

Asian J Androl 2018 Dec 7. Epub 2018 Dec 7.

Laboratory of Seminology, Sperm Bank "Loredana Gandini", Department of Experimental Medicine, Medical Pathophysiology Section, "Sapienza" University of Rome, Rome 00161, Italy.

Inhibin B is a gonadal hormone that downregulates the pituitary production of follicle-stimulating hormone (FSH). In recent years, inhibin B has proved to be an excellent marker of spermatogenesis and even a predictive factor for the recovery of fertility in patients undergoing orchiectomy and antineoplastic treatments. We propose to study inhibin B levels in orchiectomised testicular cancer patients, in order to identify a minimum value representative of normal semen quality. Read More

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December 2018

Pravastatin attenuates testicular damage induced by doxorubicin - a stereological and histopatological study.

J Basic Clin Physiol Pharmacol 2018 Dec 11. Epub 2018 Dec 11.

Cellular and Molecular Research Center, Department of Anatomical Sciences, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background The aim of this study is to investigate the effects of pravastatin (PS) against doxorubicin (DOX)-induced testicular toxicity. Methods A total of 24 healthy male Sprague-Dawley rats were equally divided into four groups. Group I received normal saline, Group II received PS (20 mg/kg b. Read More

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December 2018

Effect of molybdenum on reproductive function of male mice treated with busulfan.

Theriogenology 2018 Dec 3;126:49-54. Epub 2018 Dec 3.

Animal College of Science and Technology, Henan University of Science and Technology, Luoyang, 471003, PR China.

Infertility is a serious public health problem worldwide. Molybdenum (Mo) plays an important role in maintaining normal metabolism. To explore the therapeutic efficacy of molybdenum (Mo) on male infertility, 90 mice were randomly divided into control, busulfan and busulfan + Mo groups. Read More

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December 2018

Effect of antiepileptic drug (Topiramate) and cold pressed ginger oil on testicular genes expression, sexual hormones and histopathological alterations in mice.

Biomed Pharmacother 2018 Dec 5;110:409-419. Epub 2018 Dec 5.

Agricultural Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig, 44519, Egypt. Electronic address:

Sexual dysfunction in the epileptic patient is difficult to confirm whether it is ailment or therapy related. Antiepileptic drugs often use in reproductive age, through reproductive progress and maturation. On the other side, cold-pressed oils are rich in bioactive phytochemicals with health-promoting traits. Read More

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December 2018
2.023 Impact Factor

Testicular Acute Segmental Infarct Following Endovascular Repair of a Juxta-renal Abdominal Aortic Aneurysm: Case Report and Literature Review.

Urology 2018 Dec 5. Epub 2018 Dec 5.

Department of Clinical Radiology, King's College Hospital, London.

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December 2018
2.188 Impact Factor

Ontogenesis of human fetal testicular steroidogenesis at early gestational age.

Steroids 2018 Dec 4;141:96-103. Epub 2018 Dec 4.

Department of Women's and Children's Health, Pediatric Endocrinology Unit, Karolinska Institute & University Hospital, Stockholm, Sweden. Electronic address:

The onset of steroidogenesis in human fetal testes (HFT) during the first trimester is poorly investigated. One important unresolved question is the ontogeny of steroidogenic enzymes and formation of steroidogenic pathways in the HFT at early pregnancy. Our aim was to explore steroidogenesis, the expression of steroidogenic enzymes and their maturation in the HFT at gestational weeks (GW) 8-12. Read More

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December 2018

Ethylene dimethane sulfonate (EDS) ablation of Leydig cells in adult rat depletes testosterone resulting in epididymal sperm granuloma: Testosterone replacement prevents granuloma formation.

Reprod Biol 2018 Dec 5. Epub 2018 Dec 5.

Department of Biology, Texas Woman's University, Denton, Texas, USA. Electronic address:

Sperm granuloma may develop in the epididymis following vasectomy or chemical insults. Inflammation due to sperm granuloma causes abdominal and scrotal pain. Prolonged and persistent inflammation in the epididymis due to sperm granuloma may lead to infertility. Read More

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December 2018

Bilateral orchidopexies: synchronous or metachronous? Survey of BAPS and BAPU members and single-centre comparison.

J Pediatr Surg 2018 Nov 6. Epub 2018 Nov 6.

Department of Paediatric Surgery, Bristol Royal Hospital for Children, Bristol, UK.

Background/aim: Approximately 20% of undescended testes (UDT) are bilateral. It is unclear whether bilateral orchidopexy (BO) should be undertaken synchronously (SBO) or metachronously (MBO). Our aim was to investigate current UK practice and the complications of SBO vs MBO. Read More

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November 2018

Protective effects of selenium and nano-selenium on bisphenol-induced reproductive toxicity in male rats.

Hum Exp Toxicol 2018 Dec 9:960327118816134. Epub 2018 Dec 9.

5 Department of Biochemistry, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Bisphenol A (BPA) is a widespread compound associated with the manufacture of many consumer products. The BPA-induced reproductive toxicity was reported to be mainly attributed to oxidative stress. However, the role of antioxidants usage to decrease the injurious effects of BPA, on male reproductive functions, remains to unveil. Read More

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December 2018

Potential Role of microRNA-183 as a Tumor Suppressor in Hepatocellular Carcinoma.

Cell Physiol Biochem 2018 6;51(5):2065-2072. Epub 2018 Dec 6.

Department of General Surgery of East District, The Second Hospital of Hebei Medical University, Shijiazhuang,

Background/aims: Disseminated tumors, known as metastases, are responsible for ninety-percent of mortality due to cancer. Epithelial to mesenchymal transition, a phenomenon required for morphological conversion of non-motile discoid shaped epithelial cells to highly motile spindle-shaped mesenchymal cells, is thought to be a pre-requisite for metastatic progression. Metastasis-associated 1 (MTA1) protein is a prime inducer of EMT and metastatic progression in all solid tumors including hepatocellular carcinoma (HCC). Read More

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December 2018
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Surgical practice among pediatric surgeons and pediatric urologists in the Kingdom of Saudi Arabia for the management of suspected testicular torsion.

Saudi Med J 2018 Dec;39(12):1232-1237

Division of Pediatric Surgery, Department of Surgery, College of Medicine, Taibah University, Almadinah Al-munawarah, Kingdom of Saudi Arabia. E-mail.

Objectives: To review and compare clinical practice and experience among pediatric surgeons (PS) and pediatric urologists (PU) for the management of testicular torsion (TT) in the Kingdom of Saudi Arabia (KSA).

Methods: This was a cross-sectional study conducted between August 2016 and November 2017, among all PU and PS involved in the management of suspected TT in KSA. A questionnaire was distributed to participants through the Survs. Read More

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December 2018

Predictive significance of serum inhibin B on testicular haploid gamete retrieval outcomes in nonobstructive azoospermic men.

Asian J Androl 2018 Nov 30. Epub 2018 Nov 30.

Center for Reproductive Medicine, Shandong University, Jinan 250001, China.

The purpose of this study was to determine the diagnostic accuracy of serum inhibin B (INHB) as a predictor of the retrieval outcome of testicular haploid gametes (spermatids and testicular spermatozoa) in nonobstructive azoospermic men. Serum hormone levels, testicular volume, and histological evaluation were performed in 403 Chinese nonobstructive azoospermic men. Testicular haploid gamete was successfully retrieved in 213 of 403 patients (52. Read More

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November 2018

Testosterone therapy to prevent type 2 diabetes mellitus in at-risk men (T4DM): Design and implementation of a double-blind randomised controlled trial.

Diabetes Obes Metab 2018 Dec 5. Epub 2018 Dec 5.

Medical School, University of Western Australia, and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Western Australia, Australia.

Background: Low circulating testosterone is associated with an increased risk of developing type 2 diabetes (T2DM) in overweight men with impaired glucose tolerance (IGT).

Aim: To determine in a multi-centre, double-blinded placebo-controlled randomised trial, whether testosterone treatment combined with lifestyle intervention (Weight Watchers®) relative to lifestyle intervention alone, reduces T2DM incidence and improves glucose tolerance at 2 years.

Study Population: Overweight or obese men aged 50-74 years with a serum testosterone of ≤14nmol/L and IGT or newly diagnosed T2DM established by an oral glucose tolerance test (OGTT). Read More

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December 2018
2 Reads

Recombinant Human FSH Treatment Outcomes in Five Boys With Severe Congenital Hypogonadotropic Hypogonadism.

J Endocr Soc 2018 Dec 15;2(12):1345-1356. Epub 2018 Oct 15.

University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Context: Recombinant human FSH (r-hFSH), given to prepubertal boys with hypogonadotropic hypogonadism (HH), may induce Sertoli cell proliferation and thereby increase sperm-producing capacity later in life.

Objective: To evaluate the effects of r-hFSH, human chorionic gonadotropin (hCG), and testosterone (T) in such patients.

Design And Setting: Retrospective review in three tertiary centers in Finland between 2006 and 2016. Read More

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December 2018

Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor.

J Cancer 2018 31;9(23):4440-4448. Epub 2018 Oct 31.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

MPHOSPH1, which is one of the kinesin superfamily proteins, has been reported to play an essential role in the carcinogenesis and progression of several kinds of cancers. MPHOSPH1 has also been suggested to be involved in STAT3 phosphorylation in hepatocellular carcinoma. However, the biological behavior of MPHOSPH1 in testicular germ cell tumors (TGCTs) is unclear at present. Read More

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October 2018

Deep learning for detecting tumour-infiltrating lymphocytes in testicular germ cell tumours.

J Clin Pathol 2018 Dec 5. Epub 2018 Dec 5.

Nuffield Department of Surgical Sciences and NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.

Aims: To evaluate if a deep learning algorithm can be trained to identify tumour-infiltrating lymphocytes (TILs) in tissue samples of testicular germ cell tumours and to assess whether the TIL counts correlate with relapse status of the patient.

Methods: TILs were manually annotated in 259 tumour regions from 28 whole-slide images (WSIs) of H&E-stained tissue samples. A deep learning algorithm was trained on half of the regions and tested on the other half. Read More

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December 2018

Comparative Effects of Estrogen and Phytoestrogen, Genistein on Testicular Activities of Streptozotocin-Induced Type 2 Diabetic Mice.

Reprod Sci 2018 Dec 5:1933719118815576. Epub 2018 Dec 5.

3 Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

The aim of this study was to compare the effect of synthetic estrogen (E2) with a phytoestrogen and genistein in ameliorating type 2 diabetes mellitus (T2D)-mediated testicular dysfunction in mice. The streptozotocin (STZ)-induced type 2 diabetic mice were treated exogenously with either E2 or genistein for 2 durations and compared their effects on testicular activities, serum glucose, and insulin level. Type 2 diabetic mice treated with E2 for only short term (14 days) improved regressive changes in the testicular histology by increasing testosterone synthesis and improving insulin sensitivity, whereas those treated for longer duration (28 days) failed to improve testicular dysfunctions. Read More

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December 2018

Germ cell neoplasia in situ complicating 17β-hydroxysteroid dehydrogenase type 3 deficiency.

Mol Cell Endocrinol 2018 Nov 30. Epub 2018 Nov 30.

Division of Metabolism, Endocrinology, & Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA.

17β-hydroxysteroid dehydrogenase type 3 (17βHSD3) deficiency is an autosomal recessive disorder of male sex development that results in defective testosterone biosynthesis. Although mutations in the cognate HSD17B3 gene cause a spectrum of phenotypic manifestations, the majority of affected patients are genetic males having female external genitalia. Many cases do not present until puberty, at which time peripheral conversion of androgen precursors causes progressive virilization. Read More

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November 2018
1 Read

Endocrine aspects of Klinefelter syndrome.

Curr Opin Endocrinol Diabetes Obes 2018 Nov 30. Epub 2018 Nov 30.

Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Purpose Of Review: Klinefelter syndrome is the most common sex chromosome abnormality in men. Hypogonadism and testicular degeneration are almost universal. Truncal adiposity, metabolic syndrome and low bone mass occur frequently. Read More

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November 2018
1 Read

Resveratrol improves sperm parameter and testicular apoptosis in cisplatin-treated rats: Effects on ERK1/2, JNK, and Akt pathways.

Authors:
Ali A Shati

Syst Biol Reprod Med 2018 Dec 3:1-14. Epub 2018 Dec 3.

a Department of Biology , College of Science, King Khalid University , Abha , Saudi Arabia.

This study aimed to investigate the protective role of resveratrol (RES) against cisplatin (Cis)-induced testicular damage and reproductive dysfunction in rats and to examine the underlying mechanisms of protection including its effect on endoplasmic reticulum (ER) stress, P53, extracellular signal-regulated kinase (ERK)-1/2, stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and Protein kinase B (Akt) signaling. Eight-week-old Rats were divided into four groups (n = 12 each) of 1) control group: received normal saline (i.p. Read More

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December 2018
1 Read

Phyllanthus emblica leaf extract ameliorates testicular damage in rats with chronic stress.

J Zhejiang Univ Sci B 2018 Dec.;19(12):948-959

Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

Stress affects the male reproductive system and can cause sub-fertility or infertility. Although Phyllanthus emblica L. (PE) extract has been shown to have high antioxidant capacity and protective properties in damaged tissue, the preventive effects of PE extract on testicular function from stress-related impairment have never been demonstrated. Read More

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December 2018

Scintigraphic evaluation of colonic transit in children with constipation using Ga-citrate.

World J Nucl Med 2018 Oct-Dec;17(4):249-252

Hospital de Base do Distrito Federal - Nuclear Medicine Service, Brasília, Brasil.

The aim of this study was to assess the colonic transit in children and teenagers with chronic constipation. Twenty patients from 1.5 to 16 years old were included (mean age = 6. Read More

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December 2018
1 Read

Ellagic and ferulic acids protect arsenic-induced male reproductive toxicity via regulating Nfe2l2, Ppargc1a and StAR expressions in testis.

Toxicology 2018 Nov 29. Epub 2018 Nov 29.

Reproductive Physiology Laboratory, Animal Physiology Division, ICAR-National Institute of Animal Nutrition and Physiology, Adugodi, Bengaluru 560030, India.

Arsenic (As) - induced oxidative stress causes male reproductive toxicity apart from its other generalized systemic effects. Some phytochemicals through their antioxidant properties might help overcome such toxic effects. The aim of the study was to elucidate the protective role of the selected phytochemicals, ellagic and ferulic acids against the As-induced reproductive toxicity. Read More

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November 2018
1 Read

Is excision of testicular nubbin necessary in vanishing testis syndrome?

J Pediatr Surg 2018 Dec 2;53(12):2495-2497. Epub 2018 Sep 2.

Department of Paediatric Surgery, John Hunter Children's Hospital, Newcastle, Australia; University of Newcastle, Priority Research Centre GrowUpWell, Newcastle, Australia. Electronic address:

Background/purpose: Vanishing Testes Syndrome (VTS) is one of the most common causes of impalpable testes in children. The role of removal of testicular nubbins owing to malignant potential in VTS is unclear. We sought to evaluate whether testicular nubbins need to be excised owing to this potential. Read More

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December 2018
3 Reads

Immunolocalization of RFamide-related peptide 3 in a desert rodent Gerbillus tarabuli during seminiferous epithelium cycle.

Tissue Cell 2018 Dec 20;55:1-12. Epub 2018 Sep 20.

USTHB, University of Sciences and Technology of Houari Boumediene, Biological Sciences Faculty, Aride Area Research Laboratory, Algiers, Algeria.

Gerbillus tarabuli is a nocturnal seasonal breeder desert rodent with a main breeding season in spring and summer, and sexual quiescence in winter. This species is an interesting model for studying testis function in rodents. Therefore, the present study was performed firstly to investigate the stages of seminiferous epithelium cycle of Gerbillus tarabuli with a histological, morphometric and statistical study. Read More

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December 2018
1 Read

Remote ischemic conditioning in a rat model of testicular torsion: does it offer testicular protection?

J Pediatr Urol 2018 Sep 24. Epub 2018 Sep 24.

Division of Urology, Beirut, Lebanon. Electronic address:

Background: Testicular torsion is a surgical emergency mainly affecting adolescent boys, with a relatively high rate of missed torsion and testicular loss secondary to delay in prompt diagnosis and surgical intervention. With ischemic reperfusion injury as its underlying culprit, testicular torsion may respond favorably to remote ischemic conditioning (RIC) where a non-privileged site (e.g. Read More

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September 2018
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Leukemia and male infertility: past, present, and future.

Leuk Lymphoma 2018 Dec 3:1-10. Epub 2018 Dec 3.

a The Shraga Segal Dept. of Microbiology, Immunology, and Genetics , Ben-Gurion University of the Negev , Beer-Sheva , Israel.

Spermatogenesis is the process of the proliferation and differentiation of spermatogonial stem cells (SSCs) to generate sperm. Leukemia patients show impairment in some of the endocrine hormones that are involved in spermatogenesis. They also show a decrease in semen parameters before and after thawing of cryopreserved samples compared to a control. Read More

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December 2018
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Development of Spermatogenesis In Vitro in Three-Dimensional Culture from Spermatogonial Cells of Busulfan-Treated Immature Mice.

Int J Mol Sci 2018 Nov 29;19(12). Epub 2018 Nov 29.

The Shraga Segal Department of Microbiology, Immunology, and Genetics, Beer-Sheva 84105, Israel.

Aggressive chemotherapy may lead to permanent male infertility. Prepubertal males do not generate sperm, but their testes do contain spermatogonial cells (SPGCs) that could be used for fertility preservation. In the present study, we examined the effect of busulfan (BU) on the SPGCs of immature mice, and the possible induction of the survivor SPGCs to develop spermatogenesis in 3D in-vitro culture. Read More

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November 2018
1 Read

High-risk human papillomavirus in semen is associated with poor sperm progressive motility and a high sperm DNA fragmentation index in infertile men.

Hum Reprod 2018 Dec 4. Epub 2018 Dec 4.

Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.

Study Question: Does the presence of human papillomavirus (HPV) in semen impact seminal parameters and sperm DNA quality in white European men seeking medical help for primary couple's infertility?

Summary Answer: HPV seminal infections involving high-risk (HR) genotypes are associated with impaired sperm progressive motility and sperm DNA fragmentation (SDF) values.

What Is Known Already: HPV is commonly present in semen samples. However, whether the presence of HPV in semen is actually associated with impaired sperm parameters and SDF values have yet to be elucidated. Read More

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December 2018
1 Read

Expression profiles and characteristics of human lncRNA in normal and asthenozoospermia sperm.

Biol Reprod 2018 Dec 4. Epub 2018 Dec 4.

Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China.

Increasing studies have shown that specific mRNAs and miRNAs expressed in mature sperm may be related to sperm motility. However, the expression profiles and roles of lncRNAs in sperm remain unknown. In the present study, numerous lncRNAs were identified in human sperm, and some lncRNAs were expressed exclusively in sperm and testis. Read More

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December 2018

Down-regulation of steroidogenesis-related genes and its accompanying fertility decline in streptozotocin-induced diabetic male rats: ameliorative effect of metformin.

Andrology 2018 Dec 4. Epub 2018 Dec 4.

Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.

Background: Metformin has long been used for glycemic control in diabetic state. Recently, other benefits of metformin beyond blood glucose regulation have emerged.

Objectives: To investigate the effect of metformin on the expression of testicular steroidogenesis-related genes, spermatogenesis, and fertility of male diabetic rats. Read More

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December 2018

Persistence and Sexual Transmission of Filoviruses.

Viruses 2018 Dec 2;10(12). Epub 2018 Dec 2.

Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.

There is an increasing frequency of reports regarding the persistence of the Ebola virus (EBOV) in Ebola virus disease (EVD) survivors. During the 2014⁻2016 West African EVD epidemic, sporadic transmission events resulted in the initiation of new chains of human-to-human transmission. Multiple reports strongly suggest that these re-emergences were linked to persistent EBOV infections and included sexual transmission from EVD survivors. Read More

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December 2018
1 Read

Solitary Bone Metastasis as the First Presentation of Germ Cell Testicular Cancer Treated with Internal Hemipelvectomy: A Case Report.

Urol Int 2018 Dec 4:1-4. Epub 2018 Dec 4.

Department of Pelvic Surgery, A.C. Camargo Cancer Center, São Paulo, Brazil.

Solitary bone metastasis from testicular tumor is rare. In literature, only few cases of isolated bone metastasis at first presentation have been reported, and none of them have been treated with extended surgery of the pelvic bone. Case Presentation: We report the case of a 33-year-old man with an iliac bone osteolytic metastasis as the first presentation of a non-seminomatous germ-cell testis tumor (NSGCT), treated with post-chemotherapy en bloc resection of residual tumor in the left iliac bone (Type I + II internal hemipelvectomy). Read More

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December 2018
3 Reads

Identification of SEPTIN12 as a novel target of the androgen and estrogen receptors in human testicular cells.

Biochimie 2018 Dec 1. Epub 2018 Dec 1.

Department of Biological Sciences and Technology, National University of Tainan, Tainan, Taiwan. Electronic address:

SEPTIN12 (SEPT12) is a testis-enriched gene that is downregulated in the testis of infertile men with severe spermatogenic defects. While SEPT12 is involved in spermatogenic failure and sperm motility disorder, SEPT12 transcriptional regulation is still unknown. Here we report the promoter region of SEPT12 as a 245 bp segment upstream from the transcription start site. Read More

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December 2018
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Diabetes-induced testicular oxidative stress, inflammation, and caspase-dependent apoptosis: the protective role of metformin.

Arch Physiol Biochem 2018 Dec 4:1-12. Epub 2018 Dec 4.

a Department of Physiology, School of Medical Sciences , Universiti Sains Malaysia , Kubang Kerian , Kelantan , Malaysia.

Context: Metformin's effect on glycaemic control is well documented, but its effect on diabetes-induced testicular impairment has been scarcely reported.

Objective: To investigate the effects of metformin on testicular oxidative stress, inflammation, and apoptosis, which largely contribute to fertility decline in diabetic state.

Methods: Male Sprague-Dawley rats were divided into 3 groups (n = 6/group) namely: normal control (NC), diabetic control (DC), and metformin (300 mg/kg b. Read More

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December 2018
5 Reads