Search Our Scientific Publications & Authors

Invest New Drugs 2022 Jun 27. Epub 2022 Jun 27.

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Claudin6(CLDN6) is a tight junction protein of claudin-tetraspanin family and is of the earliest molecules expressed in embryonic epithelium. CLDN6 is frequently aberrantly expressed in testicular germ-cell tumors(GCT). ASP1650 is a chimeric-mouse/human-IgG1 antibody directed against CLDN6. Read More

Front Oncol 2022 10;12:910087. Epub 2022 Jun 10.

Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.

Germ cell tumors are the most common malignant tumors in male young adults. Platinum-based chemotherapy has dramatically improved the outcome of metastatic germ cell tumor patients and overall cure rates now exceed 80%. The choice of medical treatment can be guided by the prognosis estimation which is an important step during the decision-making process. Read More

Front Oncol 2022 10;12:876732. Epub 2022 Jun 10.

Cancer Biology and Epigenetics Group, Research Center of IPO Porto (CI-IPOP)/[email protected] (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Centre (Porto.CCC), Porto, Portugal.

Testicular germ cell tumors (TGCTs) are the most common cancers in young-adult male patients aged between 15 and 39 years. Hsa-miR-371a-3p is currently the most reliable biomarker for diagnosis and monitoring of these patients non-invasively in liquid biopsies, and it is destined to be introduced in the clinic due to improved performance compared to the classical serum tumor markers available. Current studies have focused on real-time quantitative PCR (RT-qPCR) protocols for its determination; still, some challenges remain, since these protocols often require preamplification steps (costly and time-consuming), and report relative levels normalized to a housekeeping microRNA, not always performed the same way. Read More

BMC Med Educ 2022 Jun 25;22(1):495. Epub 2022 Jun 25.

Health Behaviour Research Collaborative, Priority Research Centre for Health Behaviour, School of Medicine and Public Health, University of Newcastle, Callaghan, Australia.

Background: Testicular cancer is a relatively rare form of cancer but curable. In Nigeria, late presentation hinders treatment due to limited resources for diagnosis and treatment. Testicular self-examination enables men to identify the presence of lumps and any abnormality in their testes. Read More

Biochimie 2022 Jun 22. Epub 2022 Jun 22.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. Iran. Electronic address:

Combination chemotherapy seems to be a beneficial choice for some cancer patients particularly when the drugs target different processes of oncogenesis; patients treated with combination therapies sometimes have a better prognosis than those treated with single drug chemotherapy. However, research has shown that this is not always the case, and this approach may only increase toxicity without having a significant effect in augmenting the antitumor actions of the drugs. Doxorubicin (Dox) is one of the most common chemotherapy drugs used to treat many types of cancer, but it also has serious side effects, such as cardiotoxicity, skin necrosis, testicular toxicity, and nephrotoxicity. Read More

Curr Opin Urol 2022 Jul;32(4):364-372

Department of Molecular Oncology, Barts Health Cancer and Barts Health NHS Trust, London, UK.

Purpose Of Review: Germ-cell tumours of the testis affect predominantly younger males aged between 15 and 40 years, with nearly 74,500 new cases estimated globally in 2020. Their rarity and the complex morphology, mean that, in nonexpert hands, there is a significant risk of misdiagnosis of both type and staging of these neoplasms.

Recent Findings: There have been significant changes in the 2016 WHO classification of Testicular tumours that need to be understood by both pathologists and clinicians for streamlining management. Read More

Curr Opin Urol 2022 Jul;32(4):339-343

Department of Pathology, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.

Purpose Of Review: The 5th edition of WHO classification incorporates the most relevant new data available in the literature regarding tumors of the male genitourinary tract. In this review, the authors summarize and critically discuss the most relevant new information regarding tumors occurring in the stromal testis and in the paratestis that will be reported in the new edition of WHO classification of tumors of the male genitourinary tract.

Recent Findings: Signet-ring stromal tumors (SRST) and myoid gonadal stromal tumors (MGST) are two new entities brought in the 5th WHO classification of testicular tumors. Read More

Curr Opin Urol 2022 Jun 27. Epub 2022 Jun 27.

Department of Pathology, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.

Purpose Of Review: The 5th edition of WHO classification incorporates the most relevant new data available in the literature regarding tumors of the male genitourinary tract. In this review, the authors summarize and critically discuss the most relevant new information regarding tumors occurring in the stromal testis and in the paratestis that will be reported in the new edition of WHO classification of tumors of the male genitourinary tract.

Recent Findings: Signet-ring stromal tumors (SRST) and myoid gonadal stromal tumors (MGST) are two new entities brought in the 5th WHO classification of testicular tumors. Read More

Cureus 2022 May 21;14(5):e25186. Epub 2022 May 21.

Department of Neurology, UMass Chan Medical School, Worcester, USA.

The limbic system (LS) coordinates an important role in memory generation, creating an emotional response to stress, and helping regulate autonomic and endocrine functions. Dysfunction of the limbic system can present secondary to many pathologies including autoimmune, infectious, paraneoplastic, etc. Lesions to the limbic system can also lead to varying symptoms which can be challenging for physicians to correctly identify and treat. Read More

Cancers (Basel) 2022 Jun 18;14(12). Epub 2022 Jun 18.

Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT 84132, USA.

Concurrently acquired positron emission tomography and computed tomography (PET-CT) is an advanced imaging modality with diverse oncologic applications, including staging, therapeutic assessment, restaging and longitudinal surveillance. This series of six review articles focuses on providing practical information to providers and imaging professionals regarding the best use and interpretative strategies of PET-CT for oncologic indications in adult patients. In this fourth article of the series, the more common gynecological and adult genitourinary malignancies encountered in clinical practice are addressed, with an emphasis on Food and Drug Administration (FDA)-approved and clinically available radiopharmaceuticals. Read More

Cancers (Basel) 2022 Jun 14;14(12). Epub 2022 Jun 14.

Department of Comparative Biosciences, University of Illinois, Urbana-Champaign, Urbana, IL 61802, USA.

Poly- and perfluoroalkylated substances (PFAS) are chemicals that persist and bioaccumulate in the environment and are found in nearly all human populations through several routes of exposure. Human occupational and community exposure to PFAS has been associated with several cancers, including cancers of the kidney, testis, prostate, and liver. While evidence suggests that PFAS are not directly mutagenic, many diverse mechanisms of carcinogenicity have been proposed. Read More

BMC Complement Med Ther 2022 Jun 23;22(1):170. Epub 2022 Jun 23.

Department of biochemistry, Fasa university of medical sciences, P.O. Box: 7193635899, Shiraz, Iran.

Background: Busulfan is an antineoplastic medication that is broadly utilized for cancer treatment. It affects the testicular function and leads to sterility. The present study aimed to evaluate the effects of ellagic acid on testicular tissue changes, sexual hormones, antioxidant defense system, and caspase-9 and Bcl2 gene expression in the busulfan-induced relative sterile rat model. Read More

Dis Aquat Organ 2022 Jun 23;149:145-154. Epub 2022 Jun 23.

Department of Pathology, University of Veterinary Medicine Hannover, Foundation, Bünteweg 17, 30559 Hannover, Germany.

Harbour porpoises are widely distributed in the North Atlantic and represent the most abundant cetacean species in the North and Baltic Seas. Spontaneous neoplasms are relatively rarely reported in cetaceans, and only little is known about neoplasia in harbour porpoises. Thus, archival material was reviewed for spontaneous neoplasms in harbour porpoises recorded during post-mortem examinations between 1999 and 2018. Read More

Oncology (Williston Park) 2022 Jun;36(6):375-377

A man, aged 21 years, presented with a 4-month history of progressive swelling of the right testicle. Ultrasound revealed a heterogenous solid mass in the right testicle suspicious for malignancy. Further work-up included CT scans, which identified a 2-cm retroperitoneal lymph node; there was no evidence of thoracic metastases. Read More

Curr Issues Mol Biol 2022 Jan 4;44(1):222-232. Epub 2022 Jan 4.

Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.

Testicular cancer (TC) is a rare malignancy worldwide and is the most common malignancy in males aged 15-44 years. The Wnt/β-catenin signaling pathway mediates numerous essential cellular functions and has potentially important effects on tumorigenesis and cancer progression. The search for drugs to inhibit this pathway has identified a small molecule, PNU-74654, as an inhibitor of the β-catenin/TCF4 interaction. Read More

Am J Mens Health 2022 May-Jun;16(3):15579883221104900

Testicular Cancer Research Collaborative, Department of Health Sciences, College of Health Professions and Sciences, University of Central Florida, Orlando, FL, USA.

There is a need to further explore the relationship between atypical symptom reporting and stage diagnosis to help develop a clearer defined list of possible testicular cancer (TC) symptoms that could assist physicians diagnose the disease earlier. A cross-sectional study was employed to explore possible associations between TC symptom presentation and stage of diagnosis. An original 40-item survey was distributed among 698 TC survivors to determine the potential impact of several risk factors, experiences, and behaviors upon diagnosis. Read More

Front Physiol 2022 2;13:884122. Epub 2022 Jun 2.

Andrology Lab, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium.

maturation of immature testicular tissue (ITT) cryopreserved for fertility preservation is a promising fertility restoration strategy. Organotypic tissue culture proved successful in mice, leading to live births. In larger mammals, including humans, efficiently reproducing spermatogenesis remains challenging. Read More

Cureus 2022 Jun 14;14(6):e25942. Epub 2022 Jun 14.

Internal Medicine/Endocrinology, Our Lady of Lourdes Memorial Hospital, Binghamton, USA.

Testicular involvement is a rarely encountered complication of sarcoidosis. There are unique challenges involved when sarcoidosis affects the genitourinary system. These include differentiating the findings from testicular cancer, which often results in invasive procedures such as orchiectomies. Read More

Cell J 2022 May 27;24(5):277-284. Epub 2022 Apr 27.

Adjunct Research Associate Professor at Chemistry Department, Michigan State University, East Lansing, MI, USA.

Objective: It was in the early 20 century when the quest for spermatogenesis started. In vitro spermatogenesis is critical for male cancer patients undergoing gonadotoxic treatment. Dynamic culture system creates -like conditions. Read More

J Eur Acad Dermatol Venereol 2022 07;36(7):944-945

Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.

Front Med (Lausanne) 2022 31;9:816012. Epub 2022 May 31.

Department of Urology, West China Hospital, Institute of Urology, Sichuan University, Chengdu, China.

Objectives: To report the first series of testicular sex cord-stromal tumors (TSCSTs) with detailed clinicopathologic findings and long-term follow-up in the Chinese population.

Patients And Methods: From 2008 to 2018, 15 patients with TSCST were included in our study. The tumors were analyzed for epidemiological parameters, clinical characteristics, tumor markers, therapy, and follow-up data. Read More

Urol Ann 2022 Apr-Jun;14(2):196-198. Epub 2022 Apr 18.

Department of Urology, University Hospital HM Sanchinarro, HM Hospitales and ROC Clinic, Madrid, Spain.

Testicular cancer (TC) represents 1% of male neoplasms and 5% of urological tumors. Most of seminoma patients and about 55% of patients with nonseminoma TC have stage I disease at diagnosis. TC usually presents with a palpable testicular mass incidentally found by the patient himself or its partner by palpation. Read More

World J Surg Oncol 2022 Jun 16;20(1):205. Epub 2022 Jun 16.

Department of Gastroenterology and Hepatology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Background: Testicular tumor is one of the common solid tumors in young men. Testicular choriocarcinoma is a non-spermatogonial germ cell tumor, which is the rarest of all testicular cancers. Choriocarcinoma usually shows bleeding at the metastatic site, while gastrointestinal involvement is rare. Read More

Thorac Cancer 2022 Jun 15. Epub 2022 Jun 15.

Department of Thoracic Surgery, Sichuan University West China Hospital, Chengdu, People's Republic of China.

Large cell lung cancer metastases to the testis are scarce, although it is the most common malignancy and the most common site of metastases for breast, colorectal and kidney cancers. We hereby report a 28-year-old male patient admitted to our hospital with a chief complaint of scrotal enlargement, accompanied by chest pain and progressive dyspnea. The definite diagnosis was malignant pleural mesothelioma with the synchronous occurrence of large cell lung cancer with testicular metastasis. Read More

Intern Med 2022 Jun 14. Epub 2022 Jun 14.

Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Japan.

A 68-year-old man was admitted because of a left shoulder mass and swollen right testis. Pathological examinations indicated a diagnosis of diffuse large B-cell lymphoma (DLBCL) with the CD20+BCL6+MUM1+BCL2+CD10-MYC- phenotype in both lesions. G-banding of soft tissue showed 47,XY,+18, whereas testicular cells showed 47,X,+X,-Y,der (4) t (4;18) (p15;?),del (5) (q?),+13. Read More

Can Urol Assoc J 2022 Jun 9. Epub 2022 Jun 9.

Tom Baker Cancer Centre, University of Calgary, Calgary, AB, Canada.

Eur J Cancer Prev 2021 12 30;31(Suppl 1):S6-S7. Epub 2021 Dec 30.

School of Nursing and Midwifery, University College Cork, Ireland, Twitter:

Case Rep Oncol 2022 Jan-Apr;15(1):388-393. Epub 2022 Apr 8.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Neuroendocrine neoplasms are rare epithelial neoplasms with neuroendocrine differentiation. Few cases of primary testicular poorly differentiated neuroendocrine carcinomas (PD-NECs) have been reported, and secondary testicular neoplasms are rare. A 61-year-old man with a chief complaint of left testicular swelling was referred to our hospital. Read More

Am J Transl Res 2022 15;14(5):2825-2843. Epub 2022 May 15.

Department of Urology, The First Hospital of China Medical University Shenyang 110001, Liaoning, China.

Background: The functions of RNA-binding proteins (RBPs) in the occurrence and development of tumors remain largely unexplored. We established a risk signature based on RBPs to predict the prognosis, tumor-related immunity, and treatment benefits of patients with testicular germ cell tumors (TGCTs).

Methods: A risk signature was built based on RBPs closely related to survival obtained from TGCT data in The Cancer Genome Atlas (TCGA) database. Read More

Clin Genitourin Cancer 2022 May 2. Epub 2022 May 2.

Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Introduction: Elevated luteinizing hormone (LH) in combination with low-normal testosterone (mild Leydig cell insufficiency) is common in testicular cancer (TC) survivors and is associated with impaired insulin sensitivity and metabolic syndrome. The aim was to evaluate if testosterone replacement therapy (TRT) improves metabolic health in this subgroup of TC survivors.

Patients And Methods: This was a single-center, double-blind, randomized, controlled trial. Read More