30,933 results match your criteria Testicular Cancer


Genitourinary cancer patients have worse baseline semen parameters than healthy sperm bankers.

Andrology 2019 Feb 20. Epub 2019 Feb 20.

Massachusetts General Hospital, Boston, MA, USA.

Background: While the spermatotoxic properties of cancer treatments such as chemotherapy and radiation therapy are widely recognized, the effect of malignancy itself on male fertility is not clearly understood.

Objectives: To determine whether malignancy is associated with diminished semen quality prior to spermatotoxic treatment among sperm bankers.

Materials And Methods: Retrospective database review of de-identified records was obtained for all episodes of sperm banking performed at a cryobank from January 2004 to May 2017 for one of the following reasons: 'future use' (e. Read More

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http://dx.doi.org/10.1111/andr.12602DOI Listing
February 2019

Cellular origin of microRNA-371a-3p in healthy males based on systematic urogenital tract tissue evaluation.

Andrology 2019 Feb 20. Epub 2019 Feb 20.

Pathology (LEPO), Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.

Background: The microRNA-371a-3p (miR-371a-3p) has been reported to be an informative liquid biopsy (serum and plasma) molecular biomarker for both diagnosis and follow-up of patients with a malignant (testicular) germ cell tumor ((T)GCT). It is expressed in all histological cancer elements, with the exception of mature teratoma. However, normal testis, semen, and serum of males with a disrupted testicular integrity without a TGCT may contain miR-371a-3p levels above threshold, of which the cellular origin is unknown. Read More

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http://dx.doi.org/10.1111/andr.12595DOI Listing
February 2019

Defining and listing very rare cancers of paediatric age: consensus of the Joint Action on Rare Cancers in cooperation with the European Cooperative Study Group for Pediatric Rare Tumors.

Eur J Cancer 2019 Feb 19;110:120-126. Epub 2019 Feb 19.

Department of Epidemiological Research and Molecular Medicine, Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Italy. Electronic address:

Although all tumours are rare in childhood, there are some particularly rare paediatric cancers which have not benefited from advances made by the international paediatric oncology network. To establish a shared definition and produce a list of these entities, the European Union Joint Action on Rare Cancers (JARC) promoted a consensus effort. The definition was based on the incidence rates estimated using the information network on rare cancers (RARECAREnet) database, pooling data from 94 population-based cancer registries and 27 countries. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.12.031DOI Listing
February 2019

Disruption of Spermatogenesis and Infertility in Ataxia with Oculomotor Apraxia Type 2 (AOA2).

Cerebellum 2019 Feb 18. Epub 2019 Feb 18.

Cancer and Neuroscience, UQ Centre for Clinical Research (UQCCR), The University of Queensland, Building 71/918, Royal Brisbane and Women's Hospital Campus, Brisbane, QLD, 4029, Australia.

Ataxia with oculomotor apraxia type 2 (AOA2) is a rare autosomal recessive cerebellar ataxia characterized by onset between 10 and 20 years of age and a range of neurological features that include progressive cerebellar atrophy, axonal sensorimotor neuropathy, oculomotor apraxia in a majority of patients, and elevated serum alpha-fetoprotein (AFP). AOA2 is caused by mutation of the SETX gene which encodes senataxin, a DNA/RNA helicase involved in transcription regulation, RNA processing, and DNA maintenance. Disruption of senataxin in rodents led to defective spermatogenesis and sterility in males uncovering a key role for senataxin in male germ cell survival. Read More

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http://dx.doi.org/10.1007/s12311-019-01012-wDOI Listing
February 2019

The Effect of Hexavalent Chromium on the Incidence and Mortality of Human Cancers: A Meta-Analysis Based on Published Epidemiological Cohort Studies.

Front Oncol 2019 4;9:24. Epub 2019 Feb 4.

Department of Breast Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Hexavalent chromium [Cr(VI)] is an occupational carcinogen that can cause lung and nasal cancers, but its association with mortality and incidence in many other cancers is unclear. In this meta-analysis, we aimed to evaluate the relationship between exposure to Cr(VI) and the mortality and incidence of human cancers. We performed a search of the literature and extracted the standardized mortality ratios (SMRs), standardized incidence ratios (SIRs), and their corresponding 95% confidence intervals (CIs), to estimate risk values. Read More

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http://dx.doi.org/10.3389/fonc.2019.00024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369173PMC
February 2019

Adult height in relation to risk of cancer in a cohort of 22,809,722 Korean adults.

Br J Cancer 2019 Feb 19. Epub 2019 Feb 19.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.

Background: The present study examined whether adult height was associated with all site-combined or site-specific cancers.

Methods: We used a nationwide claim data of 22,809,722 Korean participants including both men and women (2009-2012). The deciles of height from different age and sex groups were merged into a new quintile. Read More

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http://dx.doi.org/10.1038/s41416-018-0371-8DOI Listing
February 2019

Potential impact of combined inhibition of 3α-oxidoreductases and 5α-reductases on prostate cancer.

Asian J Urol 2019 Jan 26;6(1):50-56. Epub 2018 Sep 26.

Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Prostate cancer (PCa) growth and progression rely on the interaction between the androgen receptor (AR) and the testicular ligands, testosterone and dihydrotestosterone (DHT). Almost all men with advanced PCa receive androgen deprivation therapy (ADT). ADT lowers circulating testosterone levels, which impairs AR activation and leads to PCa regression. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363635PMC
January 2019

Protective role of N-acetylcysteine (NAC) on human sperm exposed to etoposide.

Basic Clin Androl 2019 7;29. Epub 2019 Feb 7.

1Laboratory of Cell Biology, Department of Microscopy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto (UP), Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.

Background: Although recent progress in cancer treatment has increased patient survival and improved quality of life, reproductive side effects are still for concern. One way to decrease gonadal impairment is to use cytoprotectors. In testicular cancer, etoposide is generally used in combination with other agents, but there are no in-vitro studies of sperm exposure to etoposide and cytoprotectors, namely N-acetylcysteine (NAC). Read More

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http://dx.doi.org/10.1186/s12610-018-0082-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366041PMC
February 2019

Overall and Site-Specific Cancer Mortality in Patients on Dialysis and after Kidney Transplant.

J Am Soc Nephrol 2019 Feb 14. Epub 2019 Feb 14.

School of Public Health, University of Sydney, Sydney, Australia.

Patients with ESRD have a substantially increased cancer risk, but few studies have examined the patterns of cancer mortality along a patient's journey from dialysis to transplantation.

Methods: We identified all Australian patients on dialysis and patients with transplants from 1980 to 2014 from the Australia and New Zealand Dialysis and Transplant Registry. Using standardized mortality ratios (SMRs), we compared cancer mortality among patients on dialysis and patients with transplants versus the general population (overall and by age, sex, year, and site); we also performed a subgroup analysis excluding patients with preexisting cancers. Read More

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http://dx.doi.org/10.1681/ASN.2018090906DOI Listing
February 2019
2 Reads
9.343 Impact Factor

Altered Molecular Pathways in the Proteome of Cryopreserved Sperm in Testicular Cancer Patients before Treatment.

Int J Mol Sci 2019 Feb 5;20(3). Epub 2019 Feb 5.

Center of Excellence in Genomic Medicine Research, Jeddah 21589, Saudi Arabia.

Testicular cancer (TC) represents the most common cancer affecting men within the reproductive age and is often accompanied by major disturbances in semen parameters. Cryopreservation is recommended in these patients before initiating cancer treatment. Currently, there are no studies reporting the molecular mechanisms associated with altered semen quality in these men. Read More

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http://dx.doi.org/10.3390/ijms20030677DOI Listing
February 2019
1 Read
2.862 Impact Factor

An Unusual Case of Primary Retroperitoneal Germ Cell Tumour in a Young Man.

Eur J Case Rep Intern Med 2018 26;5(7):000900. Epub 2018 Jul 26.

Internal Medicine Department, Hospital Beatriz Ângelo, Lisbon, Portugal.

Some 2-5% of germ cell tumours are of extragonadal origin, with a retroperitoneal location being very rare. The majority of retroperitoneal germ cell tumours have metastasized from a testicular tumour. These tumours are diagnosed incidentally or symptomatically and nearly all present with high alpha-fetoprotein and lactate dehydrogenase levels. Read More

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http://dx.doi.org/10.12890/2018_000900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346782PMC
July 2018
1 Read

Fertility preservation in male patients with cancer.

Authors:
Shlomi Barak

Best Pract Res Clin Obstet Gynaecol 2019 Feb 20;55:59-66. Epub 2018 Dec 20.

Assuta University Hospital, Ashdod, Israel; Division of Obstetrics and Gynecology, Ben-Gurion University of the Negev, Israel. Electronic address:

Advances in the treatment of cancer in young patients have led to great improvements in life expectancy, which currently approaches 80% 5-year survival rate. As a result, fertility preservation and desire for paternity have become a significant issue in this group. However, a major concern is the negative impact of chemotherapy, radiotherapy, and the malignancy itself on fertility. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2018.12.004DOI Listing
February 2019
1 Read

Therapeutic effect of adipose-derived mesenchymal stem cells on Cisplatin induced testicular damage in adult male albino rat.

Ultrastruct Pathol 2019 Feb 9:1-28. Epub 2019 Feb 9.

a Histology and Cell Biology Department , Assiut University , Assiut , Egypt.

Infertility represents a major medical, economic, and psychological problem. Stem cells therapy for infertility has a great interest nowadays especially for cancer survivors at pre-reproductive and reproductive age.  Thirty-two adult male albino rats were used, divided equally into four groups; Group I (Control group) received isotonic saline intraperitoneally (i. Read More

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https://www.tandfonline.com/doi/full/10.1080/01913123.2019.1
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http://dx.doi.org/10.1080/01913123.2019.1572256DOI Listing
February 2019
5 Reads

A systematic review of radiation-induced testicular toxicities following radiotherapy for prostate cancer.

J Cell Physiol 2019 Feb 10. Epub 2019 Feb 10.

Neurogenic Inflammation Research Center, Mashhad University of Medical Science, Mashhad, Iran.

Background: Prostate cancer is the second most common malignancy in men in the world, and radiotherapy is used as a standard treatment modality for this cancer. Although this treatment modality effectively kills prostate cancerous cells, it unavoidably irradiates the organs/tissues that are away from the treatment site. In this regard, radiation-induced testicular toxicities following prostate radiotherapy can affect sexual function, reproduction, and quality of life in cancer survivors. Read More

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http://dx.doi.org/10.1002/jcp.28283DOI Listing
February 2019
2 Reads
3.839 Impact Factor

Molecular heterogeneity and early metastatic clone selection in testicular germ cell cancer development.

Br J Cancer 2019 Feb 11;120(4):444-452. Epub 2019 Feb 11.

Department of Pathology, Wytemaweg 80, 3015 CN, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Testicular germ cell cancer (TGCC), being the most frequent malignancy in young Caucasian males, is initiated from an embryonic germ cell. This study determines intratumour heterogeneity to unravel tumour progression from initiation until metastasis.

Methods: In total, 42 purified samples of four treatment-resistant nonseminomatous (NS) TGCC were investigated, including the precursor germ cell neoplasia in situ (GCNIS) and metastatic specimens, using whole-genome and targeted sequencing. Read More

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http://dx.doi.org/10.1038/s41416-019-0381-1DOI Listing
February 2019

Postnatal germ cell development during first 18 months of life in testes from boys with non-syndromic cryptorchidism and complete or partial androgen insensitivity syndrome.

J Pediatr Surg 2019 Jan 3. Epub 2019 Jan 3.

Douglas Stephens Surgical Research Group, Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, University of Melbourne, Australia; Department of Urology, The Royal Children's Hospital, Melbourne, Australia.

Introduction: Neonatal testicular germ cells/gonocytes, transform into stem cells for spermatogenesis during 'minipuberty', driving change in timing of surgery. This study examined gonocyte transformation in cryptorchid testes in children ≤18 months of age with unilateral, bilateral undescended testes (UDT), complete or partial androgen insensitivity syndrome (CAIS, PAIS) [3,4].

Material And Methods: Testicular biopsies were taken from patients with unilateral or bilateral UDT, PAIS or CAIS, aged 10 days-18 months. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.12.011DOI Listing
January 2019

Is Malignant Germ-Cell Tumor Associated With Cowden Syndrome?

Clin Genitourin Cancer 2019 Jan 10. Epub 2019 Jan 10.

Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2019.01.002DOI Listing
January 2019

Factors that impact the outcomes in testicular germ cell tumors in low-middle-income countries.

Med Oncol 2019 Feb 6;36(3):28. Epub 2019 Feb 6.

Department of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, 600020, India.

Germ cell tumors (GCTs) are one of the most common tumors in adolescents and young adults. There is paucity of data on GCT from low-middle-income countries (LMIC). The present study was conducted to assess the demographic features, clinical manifestations, pathology, and outcomes of GCT patients treated at our center. Read More

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http://dx.doi.org/10.1007/s12032-019-1252-6DOI Listing
February 2019
1 Read
2.058 Impact Factor

[Acquired undescended testes: treatment and consequences for future fertility].

Ned Tijdschr Geneeskd 2019 Jan 25;163. Epub 2019 Jan 25.

Erasmus MC, Sophia Kinderziekenhuis, afd. Urologie-Andrologie, Rotterdam.

1-3% of boys develop an acquired undescended testes (UDT), meaning that the testes cannot be returned into the scrotum after previously having been located in a stable scrotal position. Fertility issues for patients with acquired UDT are comparable to those for patients with congenital UDT. Hypothetically speaking, patients with acquired UDT are at lower risk of testicular cancer than patients with congenital UDT. Read More

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January 2019

Neoplasm Risk Among Individuals With a Pathogenic Germline Variant in DICER1.

J Clin Oncol 2019 Feb 4:JCO2018784678. Epub 2019 Feb 4.

2 Children's Hospitals and Clinics of Minnesota, Minneapolis, MN.

Purpose: DICER1 syndrome is an autosomal-dominant, pleiotropic tumor-predisposition disorder caused by pathogenic germline variants in DICER1. We sought to quantify risk, hazard rates, and the probability of neoplasm incidence accounting for competing risks ("cumulative incidence") of neoplasms (benign and malignant) and standardized incidence ratios for malignant tumors in individuals with DICER1 pathogenic variation.

Patients And Methods: We combined data from three large cohorts of patients who carry germline pathogenic variation in DICER1. Read More

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http://dx.doi.org/10.1200/JCO.2018.78.4678DOI Listing
February 2019

Identification of the X-linked germ cell specific miRNAs (XmiRs) and their functions.

PLoS One 2019 1;14(2):e0211739. Epub 2019 Feb 1.

Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan.

MicroRNAs (miRNAs) play a critical role in multiple aspects of biology. Dicer, an RNase III endonuclease, is essential for the biogenesis of miRNAs, and the germ cell-specific Dicer1 knockout mouse shows severe defects in gametogenesis. How miRNAs regulate germ cell development is still not fully understood. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211739PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358104PMC
February 2019

Preservation of Ejaculatory Function After Postchemotherapy Retroperitoneal Lymph Node Dissection (PC-RPLND) in Patients With Testicular Cancer: Template vs. Bilateral Resection.

Front Surg 2018 17;5:80. Epub 2019 Jan 17.

Department of Urology, Medical Faculty, University of Duesseldorf, Duesseldorf, Germany.

Post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) plays a crucial role in treatment of metastatic non-seminomatous germ cell cancer. To evaluate the functional outcome regarding the preservation of ejaculatory function comparing a bilateral vs. unilateral template resection in PC-RPLND patients. Read More

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http://dx.doi.org/10.3389/fsurg.2018.00080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345078PMC
January 2019
1 Read

Optimal Management of Undescended Testis in Boys with Cerebral Palsy. A Debate.

Sex Dev 2019 Feb 1. Epub 2019 Feb 1.

Cerebral palsy is a rare condition following injury of the developing brain and including nonprogressive neurological disorders, spasticity, intellectual impairment and others. Boys with cerebral palsy have a high incidence of undescended testis. Although the motives for treatment (infertility, cancer prevention, psychological aspects, testicular torsion) are not different in boys without neurological impairment, the decision-making process in boys with cerebral palsy is very difficult. Read More

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https://www.karger.com/Article/FullText/496463
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http://dx.doi.org/10.1159/000496463DOI Listing
February 2019
5 Reads

Benefits and risks of testosterone therapy in older men.

Minerva Urol Nefrol 2019 Jan 28. Epub 2019 Jan 28.

Diabetes and Endocrine Centre, Mater Dei Hospital, Msida, Malta -

Adult-onset hypogonadism is used to define androgen deficiency and its associated symptoms commonly occurring in middle-aged and elderly men, who are unable to mount an adequate compensatory gonadotropin response but may also have an element of testicular failure. It often occurs in relation with chronic metabolic conditions such as diabetes and the metabolic syndrome. There is a growing demand from elderly men for testosterone therapy. Read More

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http://dx.doi.org/10.23736/S0393-2249.19.03301-0DOI Listing
January 2019

Association Between Cancer Incidence and Mortality in Web-Based Data in China: Infodemiology Study.

J Med Internet Res 2019 Jan 29;21(1):e10677. Epub 2019 Jan 29.

School of Public Health, Tianjin Medical University, Tianjin, China.

Background: Cancer poses a serious threat to the health of Chinese people, resulting in a major challenge for public health work. Today, people can obtain relevant information from not only medical workers in hospitals, but also the internet in any place in real-time. Search behaviors can reflect a population's awareness of cancer from a completely new perspective, which could be driven by the underlying cancer epidemiology. Read More

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http://dx.doi.org/10.2196/10677DOI Listing
January 2019
2 Reads
3.428 Impact Factor

Dietary protocatechuic acid abrogates male reproductive dysfunction in streptozotocin-induced diabetic rats via suppression of oxidative damage, inflammation and caspase-3 activity.

Eur J Pharmacol 2019 Jan 26;849:30-42. Epub 2019 Jan 26.

Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria. Electronic address:

Clinical and experimental studies demonstrated that reproductive dysfunction is a non-lethal complication of diabetes. Protocatechuic acid (PCA) reportedly elicited several pharmacological effects in diabetic animals. However, there is paucity of information on the role of PCA in reproductive dysfunction associated with diabetes. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.01.033DOI Listing
January 2019
1 Read

Surgical Management of Undescended Testis - Timetable and Outcome: A Debate.

Sex Dev 2019 Jan 26. Epub 2019 Jan 26.

Around 1.4-3.8% of boys in the Western world are operated because of cryptorchidism. Read More

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http://dx.doi.org/10.1159/000496417DOI Listing
January 2019
2 Reads

Update on the management of patients with intermediate and poor-risk testicular germ cell tumors and new biological insights.

Cancer Treat Res Commun 2018 Dec 30;19:100117. Epub 2018 Dec 30.

Division of Medical Oncology, 12 de Octubre University Hospital, Avenida de Córdoba s/n 28041 Madrid, Spain.

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http://dx.doi.org/10.1016/j.ctarc.2018.100117DOI Listing
December 2018

Human testis phosphoproteome reveals kinases as potential targets in spermatogenesis and testicular cancer.

Mol Cell Proteomics 2019 Jan 25. Epub 2019 Jan 25.

Lead Pharma BV, Netherlands

Spermatogenesis is a complex cell differentiation process that includes marked genetic, cellular, functional and structural changes. It requires tight regulation, since disturbances in any of the spermatogenic processes would lead to fertility deficiencies as well as disorders in offspring. In order to increase our knowledge of signal transduction during sperm development, we carried out a large-scale identification of the phosphorylation events that occur in the human male gonad. Read More

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http://www.mcponline.org/lookup/doi/10.1074/mcp.RA118.001278
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http://dx.doi.org/10.1074/mcp.RA118.001278DOI Listing
January 2019
4 Reads

Lifelong aerobic exercise protects against inflammaging and cancer.

PLoS One 2019 25;14(1):e0210863. Epub 2019 Jan 25.

Exerkine Corporation, McMaster University Medical Center (MUMC), Hamilton, Ontario, Canada.

Biological aging is associated with progressive damage accumulation, loss of organ reserves, and systemic inflammation ('inflammaging'), which predispose for a wide spectrum of chronic diseases, including several types of cancer. In contrast, aerobic exercise training (AET) reduces inflammation, lowers all-cause mortality, and enhances both health and lifespan. In this study, we examined the benefits of early-onset, lifelong AET on predictors of health, inflammation, and cancer incidence in a naturally aging mouse model (C57BL/J6). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210863PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347267PMC
January 2019
3.234 Impact Factor

Identification of Premeiotic, Meiotic, and Postmeiotic Cells in Testicular Biopsies Without Sperm from Sertoli Cell-Only Syndrome Patients.

Int J Mol Sci 2019 Jan 22;20(3). Epub 2019 Jan 22.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben Gurion University, Beer Sheva 8410501, Israel.

Sertoli cell-only syndrome (SCOS) affects about 26.3⁻57.8% of azoospermic men, with their seminiferous tubules containing only Sertoli cells. Read More

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http://www.mdpi.com/1422-0067/20/3/470
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http://dx.doi.org/10.3390/ijms20030470DOI Listing
January 2019
3 Reads
2.862 Impact Factor

Association of Inherited Pathogenic Variants in Checkpoint Kinase 2 (CHEK2) With Susceptibility to Testicular Germ Cell Tumors.

JAMA Oncol 2019 Jan 24. Epub 2019 Jan 24.

Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Importance: Approximately 50% of the risk for the development of testicular germ cell tumors (TGCTs) is estimated to be heritable, but no mendelian TGCT predisposition genes have yet been identified. It is hypothesized that inherited pathogenic DNA repair gene (DRG) alterations may drive susceptibility to TGCTs.

Objective: To systematically evaluate the enrichment of germline pathogenic variants in the mendelian cancer predisposition DRGs in patients with TGCTs vs healthy controls. Read More

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http://dx.doi.org/10.1001/jamaoncol.2018.6477DOI Listing
January 2019
4 Reads

Adenocarcinoma of the Rete Testis: Clinicopathologic and Immunohistochemical Characterization of 6 Cases and Review of the Literature.

Am J Surg Pathol 2019 Jan 22. Epub 2019 Jan 22.

Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.

Adenocarcinoma of the rete testis is rare and its etiological and pathologic characteristics are not well studied. We therefore investigated the clinical, morphologic, and immunohistochemical features of 6 cases diagnosed at our institution and conducted a detailed review of the literature. The mean age was 64 years. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001219DOI Listing
January 2019
7 Reads

The prevalence of germline DICER1 pathogenic variation in cancer populations.

Mol Genet Genomic Med 2019 Jan 22:e555. Epub 2019 Jan 22.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland.

Background: The DICER1 syndrome is an autosomal dominant tumor-predisposition disorder associated with pleuropulmonary blastoma, a rare pediatric lung cancer. Somatic missense variation in "hotspot" codons in the RNaseIIIb domain (E1705, D1709, G1809, D1810, E1813) is observed in DICER1-associated tumors. Previously, we found the prevalence of germline pathogenic DICER1 variation in the general population is 1:10,600. Read More

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http://dx.doi.org/10.1002/mgg3.555DOI Listing
January 2019
12 Reads

Testicular germ cell tumor: a comprehensive review.

Cell Mol Life Sci 2019 Jan 22. Epub 2019 Jan 22.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing, 100101, China.

Testicular tumors are the most common tumors in adolescent and young men and germ cell tumors (TGCTs) account for most of all testicular cancers. Increasing incidence of TGCTs among males provides strong motivation to understand its biological and genetic basis. Gains of chromosome arm 12p and aneuploidy are nearly universal in TGCTs, but TGCTs have low point mutation rate. Read More

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http://dx.doi.org/10.1007/s00018-019-03022-7DOI Listing
January 2019
4 Reads

Testicular Mesothelioma: An Analysis of Epidemiology, Patient Outcomes, and Prognostic Factors.

Urology 2019 Jan 19. Epub 2019 Jan 19.

Institute of Urology, University of Southern California, Los Angeles, CA; USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA. Electronic address:

Objectives: To characterize demographic features, clinical characteristics, and oncologic outcomes of mesothelioma of the testis.

Methods: A population based search was performed using the National Cancer Institute's SEER 18 database. Patients diagnosed with malignant mesothelioma of the male genital organs from 1973 to 2015 were identified. Read More

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http://dx.doi.org/10.1016/j.urology.2019.01.009DOI Listing
January 2019
2 Reads

Management of Residual Mass in Germ Cell Tumors After Chemotherapy.

Curr Oncol Rep 2019 Jan 21;21(1). Epub 2019 Jan 21.

Department of Urology, Indiana University School of Medicine, 535 Barnhill Dr., Indianapolis, IN, 46202, USA.

Purpose Of Review: The purpose of this review is to educate medical oncologists on the management of patients with residual germ cell tumors and the role of surgical resection after platinum-based chemotherapy.

Recent Findings: Patients with non-seminomatous testicular cancer and residual enlarged retroperitoneal lymph nodes > 1 cm following induction chemotherapy with normal tumor markers should undergo a post-chemotherapy retroperitoneal lymph node dissection. All patients with primary mediastinal non-seminoma should undergo surgical resection of the mediastinal mass post-chemotherapy. Read More

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http://dx.doi.org/10.1007/s11912-019-0758-6DOI Listing
January 2019
2 Reads

The puzzling incidence of testicular cancer in New Zealand: what can we learn?

Authors:
J K Gurney

Andrology 2019 Jan 20. Epub 2019 Jan 20.

Cancer and Chronic Conditions (C3) Research Group, Department of Public Health, University of Otago, Wellington, New Zealand.

Background: Testicular germ cell tumour is the most common cancer to be diagnosed among young men. In New Zealand, we have observed some puzzling trends in the epidemiology of this disease.

Methods: We have conducted a narrative review of available evidence regarding the puzzling epidemiology of testicular germ cell tumour in New Zealand and discussed the possible drivers of these trends. Read More

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http://dx.doi.org/10.1111/andr.12584DOI Listing
January 2019
1 Read

The diagnostic performance of current tumour markers in surveillance for recurrent testicular cancer: A diagnostic test accuracy systematic review.

Cancer Epidemiol 2019 Jan 15;59:15-21. Epub 2019 Jan 15.

Nuffield Department of Primary Care Health Sciences, University of Oxford, UK. Electronic address:

In this diagnostic test accuracy systematic review we summarise the evidence on the diagnostic accuracy of blood α-fetoprotein (AFP), human chorionic gonadotropin (HCG) and lactate dehydrogenase (LDH) in surveillance for testicular cancer recurrence in adults. We searched four electronic databases for studies that reported the diagnostic accuracy of HCG, AFP, and/or LDH in sufficient detail for sensitivity and specificity to be calculated by extracting a 2 × 2 table comparing biomarker positivity with testicular cancer recurrence. Screening, data extraction and QUADAS-2 quality assessment were completed by two independent reviewers. Read More

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http://dx.doi.org/10.1016/j.canep.2019.01.001DOI Listing
January 2019
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Therapeutic supine robotic retroperitoneal lymph node dissection for post-chemotherapy residual masses in testicular cancer: technique and outcome analysis of initial experience.

J Robot Surg 2019 Jan 17. Epub 2019 Jan 17.

Max Institute of Cancer Care, New Delhi, India.

Retroperitoneal lymph node dissection (RPLND) is a therapeutic standard of care for post-chemotherapy residual masses in testicular cancer. While a robotic approach to this procedure has the potential of decreasing the morbidity associated with this major endeavour, it is often criticised for its inability to provide a bilateral complete template resection without redocking and repositioning the patient. Herein, we present the technique and initial outcomes of a supine approach to Robotic RPLND (R-RPLND) using the da Vinci Xi system, which obviates the need for repositioning or redocking for a bilateral full template resection. Read More

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http://dx.doi.org/10.1007/s11701-018-00903-0DOI Listing
January 2019

True hermaphroditism with seminoma: A case report.

Mol Clin Oncol 2019 Jan 8;10(1):97-100. Epub 2018 Nov 8.

Department of Urology, Peking University Shenzhen Hospital, Institute of Urology, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China.

The aim of the present study was to discuss the diagnosis and treatment of a patient with true hermaphroditism complicated by seminoma. The patient was a 35-year-old man who was admitted to the Peking University Shenzhen Hospital with a retractable mass in the left inguinal region for 20 years. A computed tomography examination revealed right cryptorchidism. Read More

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http://dx.doi.org/10.3892/mco.2018.1760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313949PMC
January 2019
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The Microbiome and Genitourinary Cancer: A Collaborative Review.

Eur Urol 2019 Jan 15. Epub 2019 Jan 15.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA; Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

Context: The recent discovery of the existence of a human genitourinary microbiome has led to the investigation of its role in mediating the pathogenesis of genitourinary malignancies, including bladder, kidney, and prostate cancers. Furthermore, although it is largely recognized that members of the gastrointestinal microbiota are actively involved in drug metabolism, new studies demonstrate additional roles and the potential necessity of the gastrointestinal microbiota in dictating cancer treatment response.

Objective: To summarize the current evidence of a mechanistic role for the genitourinary and gastrointestinal microbiome in genitourinary cancer initiation and treatment response. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03022838183105
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http://dx.doi.org/10.1016/j.eururo.2018.12.043DOI Listing
January 2019
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Applying Radiomics to Predict Pathology of Postchemotherapy Retroperitoneal Nodal Masses in Germ Cell Tumors.

JCO Clin Cancer Inform 2018 12;2:1-12

Jeremy Lewin, Padraig Warde, Peter Chung, Lynn Anson Cartwright, Joan Sweet, Aaron R. Hansen, and Philippe L. Bedard, Princess Margaret Cancer Centre; Michael A.S. Jewett, Robert J. Hamilton, Madhur Nayan, Ricardo Leão, Aaron R. Hansen, and Philippe L. Bedard, University of Toronto; Paul Dufort, Jaydeep Halankar, Martin O'Malley, and Ur Metser, University Health Network; and Abha Gupta, Armando Lorenzo, and Jeffrey Traubici, Hospital for Sick Children, Toronto, Ontario, Canada.

Purpose: After chemotherapy, approximately 50% of patients with metastatic testicular germ cell tumors (GCTs) who undergo retroperitoneal lymph node dissections (RPNLDs) for residual masses have fibrosis. Radiomics uses image processing techniques to extract quantitative textures/features from regions of interest (ROIs) to train a classifier that predicts outcomes. We hypothesized that radiomics would identify patients with a high likelihood of fibrosis who may avoid RPLND. Read More

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http://dx.doi.org/10.1200/CCI.18.00004DOI Listing
December 2018
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The role of tumor size, ultrasonographic findings, and serum tumor markers in predicting the likelihood of malignant testicular histology.

Asian J Androl 2019 Jan 15. Epub 2019 Jan 15.

Department of Urology, Peking University First Hospital, Beijing 100034, China.

The clinical predictive factors for malignant testicular histology remain unclear because of the low prevalence. Therefore, the aim of this study was to investigate predictors of malignant histology for testicular masses and decide more testis-sparing surgeries before surgery. This retrospective study enrolled 325 consecutive testicular mass patients who underwent radical orchiectomy (310/325) or testicular preserving surgery (15/325) from January 2001 to June 2016. Read More

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http://www.ajandrology.com/preprintarticle.asp?id=250280
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http://dx.doi.org/10.4103/aja.aja_119_18DOI Listing
January 2019
4 Reads