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IJU Case Rep 2021 May 4;4(3):167. Epub 2021 Apr 4.

Department of Urology St. Luke's International Hospital Tokyo Japan.

IJU Case Rep 2021 May 24;4(3):163-166. Epub 2021 Feb 24.

Department of Urology The Jikei University School of Medicine Tokyo Japan.

Introduction: There are few reports on indocyanine green fluorescence-guided surgery in testis-related diseases.

Case Presentation: A 38-year-old man underwent orchiectomy for left testicular cancer. Pathological diagnosis was pT1 seminoma. Read More

Cent European J Urol 2021 4;74(1):10-13. Epub 2021 Feb 4.

Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.

Introduction: Widespread use of scrotal ultrasonography has led to the detection of incidental, non-palpable small testicular masses (STMs). Historically, all intratesticular masses were treated radically, however more conservative strategies are now being applied with growing evidence that up to 80% of STMs are benign lesions. Testis-sparing surgery is deemed a gold standard in STMs. Read More

Fertil Steril 2021 May 8. Epub 2021 May 8.

NORDFERTIL Research Lab Stockholm, Department of Women's and Children's Health, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden; New Children's Hospital, Pediatric Research Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Electronic address:

Objective: To normalize age-dependent effects on standardized measures of spermatogonial quantity such as the number of spermatogonia per tubular cross-section (S/T) or fertility index.

Design: Published quantitative histologic data on human spermatogonial numbers were used to create Z-scores for reference means and tested on archived testicular tissue samples.

Setting: Retrospective cohort study. Read More

J Pediatr Surg 2021 Apr 15. Epub 2021 Apr 15.

Department of Surgery, Mott Children's Hospital, University of Michigan, Ann Arbor, MI, United States.

Background: Testicular germ cell tumors are uncommon tumors that are encountered by pediatric surgeons and urologists and require a knowledge of appropriate contemporary evaluation and surgical and medical management.

Method: A review of the recommended diagnostic evaluation and current surgical and medical management of children and adolescents with testicular germ cell tumors based upon recently completed clinical trials was performed and summarized in this article.

Results: In this summary of childhood and adolescent testicular germ cell tumors, we review the initial clinical evaluation, surgical and medical management, risk stratification, results from recent prospective cooperative group studies, and clinical outcomes. Read More

Transl Androl Urol 2021 Apr;10(4):1647-1655

Department of Urology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Background: To identify a combination of microRNAs (miRNA) to differentiate between viable tumor (V) or teratoma (T) and necrosis/fibrosis (N) in pcRPLND specimens of metastatic germ cell tumor (GCT) patients with residual masses ≥1 cm after chemotherapy. Biomarker guided therapy could reduce overtreatment with pcRPLND in patients with only N.

Methods: We selected 48 metastatic GCT patients who had undergone pcRPLND. Read More

Cell Death Discov 2021 May 8;7(1):97. Epub 2021 May 8.

Institute of cytology RAS, St-Petersburg, Russia.

Cancer-testicular Antigens (CTAs) belong to a group of proteins that under normal conditions are strictly expressed in a male's reproductive tissues. However, upon malignisation, they are frequently re-expressed in neoplastic tissues of various origin. A number of studies have shown that different CTAs affect growth, migration and invasion of tumor cells and favor cancer development and metastasis. Read More

Andrology 2021 May 8. Epub 2021 May 8.

Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome Viale Regina Elena, 324, 00161, Roma, Italy.

Background: Multiparametric MRI of the scrotum has been established as a useful second-line diagnostic tool for the investigation of scrotal diseases. Recently, recommendations on clinical indications for scrotal MRI were issued by the Scrotal and Penile Imaging Working Group of the European Society of Urogenital Radiology.

Objective: To update current research on when to ask for an MRI of the scrotum. Read More

Andrology 2021 May 6. Epub 2021 May 6.

Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, 77030.

Background: Cancer treatment of prepubertal patients impacts future fertility due to the abolition of spermatogonial stem cells (SSCs). In macaques, spermatogenesis could be regenerated by intratesticular transplantation of SSCs, but no studies have involved cytotoxic treatment before puberty and transplantation after puberty, which would be the most likely clinical scenario.

Objectives: To evaluate donor-derived functional sperm production after SSC transplantation to adult monkeys that had received testicular irradiation during the prepubertal period. Read More

World J Urol 2021 May 7. Epub 2021 May 7.

Department of Urology, Naval Medical Center San Diego, San Diego, CA, USA.

Objective: To evaluate the perioperative and oncological outcomes after post-chemotherapy robot-assisted retroperitoneal lymph node dissection (PC-RARPLND).

Materials And Methods: We retrospectively reported the perioperative and oncological outcomes of all the patients with testicular cancer who underwent PC-RARPLND at three tertiary teaching centers. Descriptive statistical measures were used to report demographic, clinical, intraoperative, postoperative and oncological outcomes. Read More

Front Surg 2021 20;8:626143. Epub 2021 Apr 20.

Engineering Faculty, Queensland University of Technology, Brisbane, QLD, Australia.

Patients often opt for implantation of testicular prostheses following orchidectomy for cancer or torsion. Recipients of testicular prostheses report issues regarding firmness, shape, size, and position, aspects of which relate to current limitations of silicone materials used and manufacturing methods for soft prostheses. We aim to create a 3D printable testicular prosthesis which mimics the natural shape and stiffness of a human testicle using a lattice infill structure. Read More

PLoS One 2021 4;16(5):e0251028. Epub 2021 May 4.

Department of Molecular Biology, Instituto de Investigaciones Biológicas Clemente Estable (IIBCE), Montevideo, Uruguay.

SPATS1 (spermatogenesis-associated, serine-rich 1) is an evolutionarily conserved, testis-specific protein that is differentially expressed during rat male meiotic prophase. Some reports have suggested a link between SPATS1 underexpression/mutation and human pathologies such as male infertility and testicular cancer. Given the absence of functional studies, we generated a Spats1 loss-of-function mouse model using CRISPR/Cas9 technology. Read More

Arch Esp Urol 2021 May;74(4):397-403

Servicio de Urología. Hospital Alemán de Buenos Aires. Ciudad de Buenos Aires. Argentina.

Introduction: The active surveillance (AS) of testicular tumors (seminoma and non-seminoma) is the most frequent management option in the stage I disease. Relapses generally occurred within the first 3 years and <5% appear after this time cut-off point is fulfilled. Therefore, the adherence is one of the most important pillars in the AS protocol. Read More

Data Brief 2021 Jun 27;36:107014. Epub 2021 Mar 27.

School of Public Health, Brown University, Providence, RI 02903, USA.

In a population-based case control study of testicular germ cell tumors (TGCT), we reported a strong positive association between serum levels of Wolff's Group 1 (potentially estrogenic) polychlorinated biphenyl (PCBs) and risk of TGCT, and the observed associations were similar for both seminoma and non-seminoma. While the observed specific associations between TGCT and Wolff's Group 1 PCBs cannot be easily explained by bias or confounding, a question can still be asked, that is, could the relationship between PCBs and TGCT differ by age at diagnosis? PCBs tend to bioaccumulate, with more heavily chlorinated PCB congeners tending to have longer half-lives. Half-lives of PCB congeners were reported ranging from 4. Read More

Iran J Pathol 2021 21;16(2):232-236. Epub 2020 Dec 21.

Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Iran.

Germ cell teratomas belong to non-seminomatous germ cell tumors and account for 95% of malignant testicular tumors. Regarding the current World Health Organization (WHO) criteria, testicular teratomas are divided into prepubertal and post-pubertal subtypes based on patients' age. The term "burned-out testicular tumor" is a very rare condition referring to a regressed testicular tumor which presents with its metastases without any clinical finding in the testicle. Read More

Psychooncology 2021 Apr 14. Epub 2021 Apr 14.

MRC Centre for Transplantation, Guy's Hospital Campus, King's College London, King's Health Partners, London, UK.

Objectives: Several patient-reported outcome measures (PROMs) are available for the assessment of quality of life (QoL), anxiety and depression for testicular cancer (TCa); however, these PROMs have uncertain validation of their psychometric properties for TCa-only cohorts. This systematic review aims to critically analyse and evaluate the psychometric properties of these QoL, anxiety and depression PROMs.

Methods: PubMed, EMBASE and PsycInfo were searched by two independent reviewers from inception to August 2020. Read More

J Med Case Rep 2021 May 1;15(1):222. Epub 2021 May 1.

Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife, Osun, Nigeria.

Background: Prostatic carcinoma is emerging as the most common male malignancy in Nigeria and the second most common male cancer worldwide. Patients often present with locally advances stages, and common sites of metastasis are the spine, pelvis, chest, and long bones. Metastases to the testes and spermatic cords are reputed to be rare and may be indicative of a worse outcome, when they occur. Read More

Cancer Epidemiol Biomarkers Prev 2021 Apr 29. Epub 2021 Apr 29.

Division of Cancer Epidemiology and Genetics, National Cancer Institute.

Background: The success of immunotherapy highlights a possible role for immunity in controlling cancer during remission for cancer patients in the general population. A prior cancer diagnosis is common among solid organ transplant candidates, and immunosuppressive medications administered to transplant recipients may increase recurrence risk.

Methods: Using linked data from the United States solid organ transplant registry and 13 cancer registries, we compared overall and cancer-specific survival among cancer patients who did vs. Read More

Am J Mens Health 2021 Mar-Apr;15(2):15579883211012601

Department of Kinesiology and Physical Education, University of Toronto, Toronto, Canada.

Exploring tenets of basic psychological needs theory, the objective of this study was to examine the association between psychological needs satisfaction, exercise behavior, and physical and mental health among testicular cancer survivors. The present study investigated whether psychological needs satisfaction was directly associated with increased self-rated health, and if this relationship was mediated by engagement in exercise. Testicular cancer survivors ( = 135; = 32. Read More

Int J Mol Sci 2021 Apr 20;22(8). Epub 2021 Apr 20.

Translational Research Unit, Faculty of Medicine, Comenius University, Klenova 1, 833 10 Bratislava, Slovakia.

The majority of patients with testicular germ cell tumors (GCTs) can be cured with cisplatin-based chemotherapy. However, for a subset of patients present with cisplatin-refractory disease, which confers a poor prognosis, the treatment options are limited. Novel therapies are therefore urgently needed to improve outcomes in this challenging patient population. Read More

Animals (Basel) 2021 Apr 16;11(4). Epub 2021 Apr 16.

Department of Zoology, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo 11757, Egypt.

Cisplatin (Cis) a drug commonly used as a chemotherapeutic agent to treat various types of cancer, inducing testicular damage. The present study aimed to investigate the inhibitory potential of bone marrow-derived mesenchymal stem cells (BM-MSCs) and beetroot extract (BRE) in albino rats after testicular toxicity induced by cisplatin. Thirty adult male albino rats were grouped into: the control group, Cis group receiving a single dose of 7 mg/kg i. Read More

Cancers (Basel) 2021 Apr 25;13(9). Epub 2021 Apr 25.

Department of Laboratory Medicine, Lund University, Scheelevägen 2, 223 81 Lund, Sweden.

Cisplatin is one of the most commonly used drugs for the treatment of various solid neoplasms, including testicular, lung, ovarian, head and neck, and bladder cancers. Unfortunately, the therapeutic efficacy of cisplatin against colorectal cancer is poor. Various mechanisms appear to contribute to cisplatin resistance in cancer cells, including reduced drug accumulation, enhanced drug detoxification, modulation of DNA repair mechanisms, and finally alterations in cisplatin DNA damage signaling preventing apoptosis in cancer cells. Read More

Cancers (Basel) 2021 Apr 23;13(9). Epub 2021 Apr 23.

Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA.

Testicular germ cell tumors (TGCTs) are exceptionally sensitive to genotoxic chemotherapy, resulting in a high cure rate for the young men presenting with these malignancies. However, this treatment is associated with significant toxicity, and a subset of malignant TGCTs demonstrate chemoresistance. Mixed nonseminomas often contain pluripotent embryonal carcinoma (EC) cells, the cancer stem cells (CSCs) of these tumors. Read More

Cancers (Basel) 2021 Apr 7;13(8). Epub 2021 Apr 7.

Department of Pathomorphology, Medical University of Gdansk, 80214 Gdansk, Poland.

In the current study, we aimed to investigate whether expression of immune checkpoint proteins (V-domain Ig suppressor of T cell activation (VISTA) and programmed death-ligand 1 (PD-L1)) and markers of systemic inflammation could predict progression/relapse and death in the cohort of 180 patients with testicular germ-cell tumors (GCTs). Expression of PD-L1 and VISTA was assessed by immunohistochemistry utilizing tissue microarrays. To estimate systemic inflammation neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) were calculated. Read More

Cancers (Basel) 2021 Apr 1;13(7). Epub 2021 Apr 1.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA.

This study aimed to compare histological features of familial and sporadic testicular germ cell tumors (TGCTs) and surrounding parenchyma, since discriminating features might be etiologically relevant and clinically useful. The study of parenchyma was prompted by reports claiming a higher prevalence of testicular microlithiasis in familial cases. Histological features of TGCTs and surrounding parenchyma of 296 sporadic and 305 familial cases were compared. Read More

J Pediatr Adolesc Gynecol 2021 Apr 25. Epub 2021 Apr 25.

Division of Pediatric and Adolescent Gynecology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 1(st) St SW, Rochester MN 55905 USA. Electronic address:

Study Objectives: To describe the structure of a pediatric fertility preservation (FP) program and share safety and patient satisfaction data.

Design: The FP program operates under prospective research protocols approved by the Mayo Clinic Institutional Review Board (IRB).

Setting: The FP program is a multidisciplinary effort between pediatric gynecology, reproductive endocrinology, pediatric urology, pediatric surgery, and laboratory medicine. Read More

Andrologia 2021 Apr 27:e14078. Epub 2021 Apr 27.

Ultrasound Department, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Small testicular solid lesions are discovered accidentally due to the extensive use of ultrasound in urology and andrology. Early differentiation between benign and malignant testicular neoplasms is crucial for the determination of treatment options, especially for sub-centimetre lesions. We report a case of a male patient with an incidental discovery of a small testicular lesion on ultrasonography with the chief complaint of left testicular discomfort. Read More

Redox Biol 2021 Apr 16;43:101969. Epub 2021 Apr 16.

Laboratory of Medical Systems Biology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 510623, Guangzhou, China. Electronic address:

Fibrous sheath interacting protein 1 (Fsip1) is a cytoskeletal structural protein of the sperm flagellar proteome. A few studies have reported that it plays a vital role in the tumorigenesis and cancer progression. However, little is known about the role of Fsip1 in spermatogenesis and mammalian sperm flagellogenesis. Read More

J Bone Miner Res 2021 Apr 26. Epub 2021 Apr 26.

Department of Internal Medicine, Division of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, Michigan.

Bone metastasis is a complication of prostate cancer in up to 90% of men afflicted with advanced disease. Therapies that reduce androgen exposure remain at the forefront of treatment. However, most prostate cancers transition to a state whereby reducing testicular androgen action becomes ineffective. Read More