2,213 results match your criteria Testicle Trauma

Pelvic Fracture Associated with Intrapelvic Dislocation of Testis.

J Orthop Case Rep 2021 Feb;11(2):90-94

Department of Orthopaedic Surgery, Bombay Hospital, Indore, Madhya Pradesh, India.

Introduction: Intrapelvic testicular dislocation is rare injury with the possibility of missed or delayed diagnosis. Timely diagnosis of intrapelvic testicular dislocation can prevent iatrogenic testicular injury during surgery and its long-term sequel.

Case Report: A 30-year-old male after motorbike accident presented with a pelvic injury with intrapelvic dislocation of testis. Read More

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February 2021

A cohort autopsy study defines COVID-19 systemic pathogenesis.

Cell Res 2021 Jun 16. Epub 2021 Jun 16.

Department of Critical Care Medicine, PLA Key Laboratory of Emergency and Critical Care Research, Jinling Hospital, Nanjing University, Nanjing, Jiangsu, China.

Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by dysfunction of the lungs and extrapulmonary organs. However, the organotropism of SARS-CoV-2 and the port of virus entry for systemic dissemination remain largely unknown. We profiled 26 COVID-19 autopsy cases from four cohorts in Wuhan, China, and determined the systemic distribution of SARS-CoV-2. Read More

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Dynamic Protective Effect of Chinese Herbal Prescription, Yiqi Jiedu Decoction, on Testis in Mice with Acute Radiation Injury.

Evid Based Complement Alternat Med 2021 1;2021:6644093. Epub 2021 Jun 1.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Objective: A Chinese herbal prescription, Yiqi Jiedu (YQJD) decoction, is used for injuries caused by radiotherapy. This study aimed to investigate the dynamic protective effects of YQJD decoction in mice on radiation damage at different time points of the testis.

Methods: The 200 male Balb/c mice were randomly divided into 5 groups (blank, model, Anduolin, low-dose YQJD, and high-dose YQJD groups). Read More

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Effects of hypothermia and pentoxifylline on the adnexal torsion/detorsion injuries in a rat testis model.

Andrologia 2021 Jun 11:e14143. Epub 2021 Jun 11.

Department of Anatomy, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.

This study was designed to investigate the effects of separate and combined administration of hypothermia and pentoxifylline to preserve the effects on the testicles in an experimental model of testicular torsion/ detorsion injuries in rats. Forty male adult Wistar rats were randomly divided into five groups, control, torsion/detorsion (TD), torsion/detorsion/hypothermia (TD+ICE), torsion/detorsion received of pentoxifylline (40mg/kg, ip) (TD+PTX) and torsion/detorsion/hypothermia/PTX (TD+ICE+PTX). Left testicular torsion (TT) was performed for 4 and half hours, and ice fragments have been used at the beginning of torsion. Read More

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Role of multiparametric ultrasound in testicular focal lesions and diffuse pathology evaluation, with particular regard to elastography: Review of literature.

Andrology 2021 Jun 11. Epub 2021 Jun 11.

Department of Radiological Sciences, Oncology and Pathology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

Background: Ultrasound is the main requested technique for the assessment of traumatic, vascular, neoplastic, and inflammatory testicular pathology. Moreover, the role of ultrasound has broadened over the years along with the introduction of new techniques, such as contrast enhanced ultrasound and ultrasound elastography.

Objective: An updated representation of the pre-existing Literature evidence for multiparametric ultrasound imaging with particular regard to elastography, in the evaluation of focal and diffuse testicular pathologies, has been presented. Read More

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Accelerated and Improved Vascular Maturity after Transplantation of Testicular Tissue in Hydrogels Supplemented with VEGF- and PDGF-Loaded Nanoparticles.

Int J Mol Sci 2021 May 28;22(11). Epub 2021 May 28.

Gynecology-Andrology Unit, Institute of Experimental and Clinical Research, Medical School, Catholic University of Louvain, UCLouvain, 1200 Brussels, Belgium.

Avascular transplantation of frozen-thawed testicular tissue fragments represents a potential future technique for fertility restoration in boys with cancer. A significant loss of spermatogonia was observed in xeno-transplants of human tissue most likely due to the hypoxic period before revascularization. To reduce the effect of hypoxia-reoxygenation injuries, several options have already been explored, like encapsulation in alginate hydrogel and supplementation with nanoparticles delivering a necrosis inhibitor (NECINH) or VEGF. Read More

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Domestic trauma with penile and scrotum skin degloving and testicular avulsion.

J Surg Case Rep 2021 May 26;2021(5):rjab175. Epub 2021 May 26.

Urological Clinic, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, Italy.

Traumatic lesions of male external genitalia are certainly less frequent than the other body sites and in the majority of cases they are caused by work accidents in the metalworking environment or by gunshot wounds. We present a rare case of traumatic degloving lesion of the male external genitalia with avulsion of the left testis caused by an accidental fall from the ladder. Reconstructive surgery was carried out in a single procedure, obtaining an excellent esthetic and functional result. Read More

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Use of contrast enhanced ultrasound in testicular diseases: A comprehensive review.

Andrology 2021 May 27. Epub 2021 May 27.

Department of Experimental Medicine, Sapienza University, Rome, Italy.

Background: Contrast-enhanced ultrasound (CEUS) is a sonographic technique that increases the diagnostic accuracy of ultrasound and color Doppler ultrasound (CDUS) when studying testicular abnormalities. However, its role in clinical practice is still debatable because there are no accepted standards regarding how and when this technique should be used for patients with testicular disease.

Objectives: To perform a nonsystematic review of the current literature to highlight the strength and flaws of performing CEUS and to provide a critical overview of current research evidence on this topic. Read More

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Testicular rupture after blunt scrotal trauma in children: A case report and literature review.

Trauma Case Rep 2021 Jun 23;33:100482. Epub 2021 Apr 23.

Nancy Regional University Hospital Center, Nancy, France.

Blunt testicular trauma with rupture of albuginea is one of the rarest emergencies in children. Medical history and Testicular Doppler Ultrasound lead to diagnosis. Appropriate management is necessary to preserve the testis. Read More

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A case at crossroads-urological presentation, cardiac complication and haematological diagnosis: should imaging be pursued prior to orchidectomy at all costs?

J Surg Case Rep 2021 May 14;2021(5):rjab177. Epub 2021 May 14.

Barts Health Trust, London, UK.

This case report explores the interesting case of a 71-year-old gentleman who presented with a testicular lump following trauma. Ultrasound imaging of the testicle demonstrated malignancy and subsequently orchidectomy was listed. Due to a scheduling difficulty, this was prioritized ahead of his whole-body computed tomography scan. Read More

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When to ask for an MRI of the scrotum.

Andrology 2021 May 8. Epub 2021 May 8.

Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Roma, Italy.

Background: Multiparametric MRI (mpMRI) of the scrotum has been established as a useful second-line diagnostic tool for the investigation of scrotal diseases. Recently, recommendations on clinical indications for scrotal MRI were issued by the Scrotal and Penile Imaging Working Group of the European Society of Urogenital Radiology.

Objective: To update current research on when to ask for an MRI of the scrotum. Read More

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Fluorochloridone induces autophagy in TM4 Sertoli cells: involvement of ROS-mediated AKT-mTOR signaling pathway.

Reprod Biol Endocrinol 2021 Apr 26;19(1):64. Epub 2021 Apr 26.

School of Public Health/MOE Key Laboratory for Public Health Safety/NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, 200032, China.

Background: Fluorochloridone (FLC), a selective pyrrolidone herbicide, has been recognized as a potential endocrine disruptor and reported to induce male reproductive toxicity, but the underlying mechanism is unclear. The aim of this study was to investigate the mechanism of FLC-induced reproductive toxicity on male mice with particular emphasis on the role of autophagy in mice' TM4 Sertoli cells.

Methods: Adult C57BL/6 mice were divided into one control group (0. Read More

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Blunt Trauma Resulting in Testicular Evisceration: A Case Report.

Cureus 2021 Mar 21;13(3):e14019. Epub 2021 Mar 21.

Urology, Riverside Community Hospital - HCA Healthcare, Riverside, USA.

Scrotal and testicular injuries are uncommon injuries, accounting for only a fraction of all trauma. Blunt scrotal trauma is accompanied by testicular rupture in up to 50% of cases. We present a rare case of scrotal rupture with evisceration of a viable, intact testicle after a motor vehicle accident. Read More

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Penetrating scrotal injury in childhood.

Urol Case Rep 2021 Jul 16;37:101635. Epub 2021 Mar 16.

Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.

An 11-year-old boy was referred to the emergency room (ER) because of a stab wound on the scrotum due to a tree trunk. The external genitalia computed tomography (CT) scan revealed a 5-cm long stick that was stuck in his left hemiscrotum; however, the testis was normal. Scrotal exploration and debridement of non-viable tissue was performed, and no testicular or surrounding structure injury was found. Read More

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The effect of astaxanthin on testicular torsion-detorsion injury in rats - Detailed morphometric evaluation of histological sections.

J Pediatr Urol 2021 Mar 27. Epub 2021 Mar 27.

Department of Histology and Embriology, University of Zagreb, School of Medicine, Šalata 3, Zagreb, 10000, Croatia.

Introduction: Testicular torsion is one of the conditions of the acute scrotum that requires immediate surgical intervention. If not recognized at time, it can result of ischemic injuries and testicular loss. Restoration of blood flow is essential to save ischemic tissue, but reperfusion itself paradoxically causes further damage. Read More

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Spontaneous testicular silicone prosthesis rupture, a rare event.

Urol Case Rep 2021 Jul 12;37:101626. Epub 2021 Mar 12.

Department of Radiology and Medical Imaging, University of Virginia Health System, 1215 Lee St., Charlottesville, VA, USA, 22908.

Testicular prostheses are utilized to improve cosmetic outcomes and reduce the psychological impact of native tissue loss particularly related to trauma, neoplasm, or malignancy. Implant rupture is usually related to trauma and spontaneous prosthesis rupture is a rare event. We report a case of an incidental spontaneous rupture in an asymptomatic patient status post orchiectomy and silicone gel filled prosthesis insertion for left cryptorchidism. Read More

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Crocetin Mitigates Irradiation Injury in an In Vitro Model of the Pubertal Testis: Focus on Biological Effects and Molecular Mechanisms.

Molecules 2021 Mar 17;26(6). Epub 2021 Mar 17.

Lab of Nutritional Biochemistry, Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.

Infertility is a potential side effect of radiotherapy and significantly affects the quality of life for adolescent cancer survivors. Very few studies have addressed in pubertal models the mechanistic events that could be targeted to provide protection from gonadotoxicity and data on potential radioprotective treatments in this peculiar period of life are elusive. In this study, we utilized an in vitro model of the mouse pubertal testis to investigate the efficacy of crocetin to counteract ionizing radiation (IR)-induced injury and potential underlying mechanisms. Read More

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Consensus exercise identifying priorities for research in the field of general surgery of childhood in the UK.

BJS Open 2021 03;5(2)

Department of Paediatric Surgery, Leeds General Infirmary, Leeds, UK.

Background: The evidence base underlying clinical practice in children's general surgery is poor and high-quality collaborative clinical research is required to address current treatment uncertainties. The aim of this study was, through a consensus process, to identify research priorities for clinical research in this field amongst surgeons who treat children.

Methods: Questions were invited in a scoping survey amongst general surgeons and specialist paediatric surgeons. Read More

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Testicular Dislocation After Unstable Pelvic Ring Injury.

Cureus 2021 Feb 4;13(2):e13119. Epub 2021 Feb 4.

Orthopedic Surgery, OhioHealth, Columbus, USA.

Reproductive and genitourinary complications following pelvic ring injuries have been described; however, testicular dislocation is rare and can cause significant morbidity if not managed appropriately. We describe a case of testicular dislocation after pelvic ring injury and outline the subsequent management and outcome, and seek to identify areas of improvement to ensure expedient and appropriate care in the setting of these injuries. Our case describes a 29-year-old male who presented to a level-one trauma center following a motorcycle collision. Read More

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February 2021

N-acetyl cysteine co-treatment abates perfluorooctanoic acid-induced reproductive toxicity in male rats.

Andrologia 2021 Jun 16;53(5):e14037. Epub 2021 Mar 16.

School of Biochemistry and Chemistry, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.

Perfluorooctanoic acid is a synthetic perfluoroalkyl-persistent in the environment and toxic to humans. N-acetylcysteine is a pro-drug of both amino acid l-cysteine and glutathione-a non-enzymatic antioxidant. N-acetylcysteine serves as an antidote for paracetamol poisoning and alleviates cellular oxidative and inflammatory stressors. Read More

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Exploring the Stress Impact in the Paternal Germ Cells Epigenome: Can Catecholamines Induce Epigenetic Reprogramming?

Front Endocrinol (Lausanne) 2020 19;11:630948. Epub 2021 Feb 19.

Instituto de Investigaciones Farmacológicas (Universidad de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Técnicas), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.

Spermatogenesis is characterized by unique epigenetic programs that enable chromatin remodeling and transcriptional regulation for proper meiotic divisions and germ cells maturation. Paternal lifestyle stressors such as diet, drug abuse, or psychological trauma can directly impact the germ cell epigenome and transmit phenotypes to the next generation, pointing to the importance of epigenetic regulation during spermatogenesis. It is established that environmental perturbations can affect the development and behavior of the offspring through epigenetic inheritance, including changes in small non-coding RNAs, DNA methylation, and histones post-translational modifications. Read More

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A Systematic Review of the Assessment of the Presence of SARS-CoV-2 in Human Semen.

Adv Exp Med Biol 2021 ;1321:335-342

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Theoretically, human testes are highly expressive organs for angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 receptor. This study aimed to investigate whether the causative agent of COVID-19 is found in semen. The databases of PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar were searched using a combination of related keywords. Read More

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Does SARS-CoV-2 Threaten Male Fertility?

Adv Exp Med Biol 2021 ;1321:139-146

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

In the continuing COVID-19 pandemic, one of the most important concerns in reproductive health is the issue of male fertility of recovered patients. In this study, we discuss the potential mechanisms that justify the possible impact of COVID-19 on male fertility. The main point of entry of SARS-CoV-2 into the host cells appears to be through the viral spike protein which permits entry into cells via the angiotensin-converting enzyme 2 (ACE2 receptor). Read More

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Scrotal trauma: interest of preoperative ultrasound in the prediction of the rupture of the tunica albuginea.

Med Glas (Zenica) 2021 02;18(1):128-132

Department of Urology, University Hospital "Ospedale Riuniti", Ancona, Italy.

Aim Scrotal bruises are quite frequent injuries affecting young subjects, with psychological repercussions on body image and fertility. The interest of ultrasound in the context of the emergency remains controversial. The aim of our study was to investigate clinical, ultrasonographic and operative features of scrotal contusions, and to evaluate the contribution of ultrasound in the description of traumatic lesions. Read More

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February 2021

Hydrogen Gas: A Novel Type of Antioxidant in Modulating Sexual Organs Homeostasis.

Oxid Med Cell Longev 2021 16;2021:8844346. Epub 2021 Jan 16.

Department of Physiology, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.

Sex is a science of cutting edge but bathed in mystery. Coitus or sexual intercourse, which is at the core of sexual activities, requires healthy and functioning vessels to supply the pelvic region, thus contributing to clitoris erection and vaginal lubrication in female and penile erection in male. It is well known that nitric oxide (NO) is the main gas mediator of penile and clitoris erection. Read More

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January 2021

Handgrip strength: a reliable predictor of postoperative early ambulation capacity for the elderly with hip fracture.

BMC Musculoskelet Disord 2021 Jan 22;22(1):103. Epub 2021 Jan 22.

Department of Orthopedics, Taichung Veterans General Hospital, Taichung, Taiwan.

Backgrounds: A common sequela of hip fracture is loss of ambulation capacity. Prediction of postoperative ambulation capacity is important for surgical and rehabilitation decision making. Handgrip strength is a quick and convenient tool for evaluating postoperative functional ability and outcome in variety of clinical conditions for the elderly and is associated with the use of walking aids. Read More

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January 2021

Small testes: clinical characteristics and ultrasonographic findings.

Ultrasonography 2021 Jul 3;40(3):455-463. Epub 2020 Nov 3.

Department of Radiology, Kyung Hee University Hospital, Seoul, Korea.

The purpose of this pictorial essay is to describe the ultrasonographic and clinical findings of patients with small testes due to a wide range of causes. We retrospectively reviewed the ultrasonographic and clinical findings of various causes of small testes. We present various causes of small testes on ultrasonography including Klinefelter syndrome, testicular torsion, mumps orchitis, inguinal hernia, cryptorchidism, varicocele, and trauma. Read More

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Imaging in scrotal trauma: a European Society of Urogenital Radiology Scrotal and Penile Imaging Working Group (ESUR-SPIWG) position statement.

Eur Radiol 2021 Jul 15;31(7):4918-4928. Epub 2021 Jan 15.

Department of Radiology, University of Rochester, 601 Elmwood ave, Rochester, NY, 14642, USA.

Imaging plays a crucial role in the evaluation of scrotal trauma. Among the imaging modalities, greyscale ultrasound and Colour Doppler ultrasound (CDUS) are the primary techniques with the selective utilisation of advanced techniques such as contrast-enhanced ultrasound (CEUS) and elastography. Despite ultrasound being the mainstay of imaging scrotal trauma, its diagnostic performance is not fully established. Read More

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COVID-19 and male reproduction: Current research and unknown factors.

Andrology 2021 Jan 11. Epub 2021 Jan 11.

Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: The testes are suspected target organs of SARS-CoV-2. However, the results of studies on the effect of COVID-19 on male reproduction are controversial.

Objective: To summarize current research on the effects of COVID-19 on male reproduction. Read More

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January 2021

[Guilingji Capsules reduce 900 MHz collphone electromagnetic radiation-induced testicular oxidative damage and downregulate Prdx2 protein expression in the rat testis].

Zhonghua Nan Ke Xue 2020 Nov;26(10):926-933

School of Integrated Traditional Chinese and Western Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, China.

Objective: To investigate the relationship of electromagnetic radiation (EMR) from 900 MHz cellphone frequency with testicular oxidative damage and its influence on the Prdx2 protein expression in the rat testis, and to explore the mechanism of Guilingji Capsules (GC) alleviating oxidative damage to the testis tissue.

Methods: Fifty healthy SD male rats were randomly divided into five groups of equal number, sham-EMR, 4-h EMR, 8-h EMR, 4-h EMR+GC and 8-h EMR+GC and exposed to 900 MHz EMR (370 μW/cm2) for 0, 4 or 8 hours daily for 15 successive days. The rats of the latter two groups were treated intragastrically with GC suspension and those of the first three groups with pure water after exposure to EMR each day. Read More

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November 2020