2,123 results match your criteria Testicle Trauma


Low Dose of Genistein Alleviates Mono-(2-Ethylhexyl) Phthalate-Induced Fetal Testis Disorder Based on Organ Culture Model.

Oxid Med Cell Longev 2020 27;2020:4569268. Epub 2020 May 27.

Department of Urology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China.

Mono-(2-ethylhexyl) phthalate (MEHP) and genistein have been classified as endocrine-disrupting chemicals (EDCs) which interfere with the differentiation and development of the male reproductive system. However, how these two EDCs would affect fetal rat testis development at a low dose was rarely studied. In this study, we established the organ culture system and applied it to evaluate testicular effects following multiple EDC exposure at a low dose. Read More

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http://dx.doi.org/10.1155/2020/4569268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275205PMC

Antioxidant property of leaf extracts reduces testicular torsion/detorsion-induced ischemia/reperfusion injury in rats.

Vet Res Forum 2020 15;11(1):27-33. Epub 2020 Mar 15.

Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.

The present study was aimed to determine the protective effects of L (PM leaf extracts on the testicular torsion/detorsion (T/D)-induced ischemia/reperfusion (I/R) injury in rats. Twenty-four mature male Sprague-Dawley rats, weighing 200-220 g, were selected. They were randomly divided into four groups of six animals each: Sham (sham-operated rats; all the surgical steps were performed but T/D was not induced), TDC (Control group; T/D was induced and the right testicular torsion of 720° lasting two hours was followed by detorsion), TDP50 (T/D-operated rats received 50. Read More

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http://dx.doi.org/10.30466/vrf.2019.102182.2432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282225PMC

Paraganglioma of the Spermatic Cord With Spinal Metastasis: A Case Report.

Urology 2020 Jun 4. Epub 2020 Jun 4.

Department of Urology, Main Line Health, Philadelphia, PA.

A 40-year-old male with presented to the clinic with the chief complaint of right inguinal pain radiating to his right testicle and right thigh with no history of trauma, fever, chills, dysuria, hematuria, or unprotected sexual activity. Physical exam revealed right testicular tenderness with no palpable abnormality of the bilateral testes or spermatic cords. Scrotal ultrasound was performed and was unremarkable for testicular or other intrascrotal pathology. Read More

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http://dx.doi.org/10.1016/j.urology.2020.05.046DOI Listing

Denial and oncological pathology: Case report of a massive testicular cancer.

Urologia 2020 May 27:391560320921714. Epub 2020 May 27.

Department of Urology, University of Turin, Torino, Italy.

Literature: The cancer of testicles represents 1% of male neoplasms and 5% of urological malignant neoplasm. Its incidence has been growing in Western societies. Cancer of testicles usually presents as an increase of consistence in one testicles and absence of pain, as a casual ultrasound scan finding, or it could be highlighted by a scrotal injury. Read More

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http://dx.doi.org/10.1177/0391560320921714DOI Listing

The role of contrast-enhanced ultrasound (CEUS) in the evaluation of scrotal trauma: a review.

Insights Imaging 2020 May 19;11(1):68. Epub 2020 May 19.

Department of Radiology, King's College Hospital NHS Foundation Trust, London, UK.

Testicular trauma is common, usually trivial and rarely requires hospital attendance, but if it does, then imaging becomes essential as scrotal assessment may be difficult due to pain and/or scrotal disruption. Ultrasound (US) assumes a crucial role as other cross-sectional modalities have a limited use in the acute presentation. Despite the acceptable accuracy of conventional US techniques, there are limitations which hinder a thorough evaluation, critically the assessment of tissue viability, crucial for clinical management and prognosis. Read More

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http://dx.doi.org/10.1186/s13244-020-00874-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237587PMC

Does a bilateral polypropylene mesh alter the duct deferens morphology, testicular size and testosterone levels? Experimental study in rats.

Acta Cir Bras 2020 17;35(2):e202000201. Epub 2020 Apr 17.

Full Professor, Division of General Surgery and Trauma, Department of Surgery, HC/FMUSP, Sao Paulo-SP, Brazil. Conception and design of the study, critical revision, final approval.

Purpose: To evaluate the effect of a PP mesh on duct deferens morphology, testicular size and testosterone levels.

Methods: Forty adult male rats were distributed into groups: 1) no surgery; 2) inguinotomy; 3) mesh placed on the duct deferens; and 4) mesh placed on the spermatic funiculus. After 90 postoperative days, the inguinal region was resected, and blood samples were collected for the measurement of serum testosterone (pg/dl). Read More

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http://dx.doi.org/10.1590/s0102-865020200020000001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184941PMC

Could polypropylene mesh impair male reproductive organs? Experimental study with different methods of implantation.

Hernia 2020 Apr 18. Epub 2020 Apr 18.

Division of General Surgery and Trauma, Department of Surgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC/FMUSP), Dr. Enéas de Carvalho Aguiar Av. 255. Cerqueira Cesar, São Paulo, 05402-000, Brazil.

Purpose: To evaluate the vas deferens and testicles of rats submitted to bilateral inguinotomy and polypropylene (PP) mesh placement.

Method: Sixty Wistar rats were randomized into three groups: Control (inguinotomy only), mesh placement over the vas deferens (Mesh-DD) or under the spermatic funiculus (Mesh-SF). The following analyses were performed: vas deferens morphometry (lumen area and wall thickness), quantification of collagen fibers, spermatogenesis, apoptosis (cleaved caspase-3 and TUNEL) and cellular proliferation (Ki67). Read More

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http://dx.doi.org/10.1007/s10029-020-02186-7DOI Listing

A case of acute hypogonadism following taipan (Oxyuranus scutellatus) envenomation.

Toxicon 2020 Jun 11;180:28-30. Epub 2020 Apr 11.

Cairns Hospital, 165 Esplanade, Cairns, Queensland, 4870, Australia; The Kirby Institute, Wallace Wurth Building, University of New South Wales, High St, Kensington, NSW, 2052, Australia. Electronic address:

A previously well man developed acute, marked tender bilateral gynaecomastia two months after confirmed taipan (Oxyuranus scutellatus) envenomation. He had had laboratory evidence of thrombotic microangiopathy (TMA) including microangiopathic haemolytic anaemia, thrombocytopenia and acute kidney injury. Scrotal ultrasound revealed bilateral testicular atrophy, his serum testosterone was repeatedly low, while his luteinising and follicle stimulating hormone were elevated. Read More

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http://dx.doi.org/10.1016/j.toxicon.2020.04.004DOI Listing

The role of multiparametric ultrasound in the diagnosis of paediatric scrotal pathology.

Br J Radiol 2020 Jun 23;93(1110):20200063. Epub 2020 Apr 23.

Department of Radiology, King's College Hospital, London. Denmark Hill, London SE5 9RS U.K, United Kingdom.

Multiparametric ultrasound (MPUS), combining conventional techniques (greyscale and colour Doppler ultrasound), ultrasound strain elastography, and contrast-enhanced ultrasound (CEUS), has been successfully used in the assessment of adult scrotal pathology. Contrast-enhanced ultrasound can confidently establish testicular tissue vascularity even in the small-volume paediatric testis. Elastography provides further assessment of tissue stiffness, potentially adding useful diagnostic information. Read More

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http://dx.doi.org/10.1259/bjr.20200063DOI Listing
June 2020
1.533 Impact Factor

Extended medial sural artery perforator free flap for groin and scrotal reconstruction.

Arch Plast Surg 2020 Apr 8. Epub 2020 Apr 8.

Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, USA.

The medial sural artery perforator (MSAP) flap is a versatile fasciocutaneous flap that has been used successfully in the reconstruction of defects across the body. In specific cases, it may prove superior to more commonly used options (e.g. Read More

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http://dx.doi.org/10.5999/aps.2019.01921DOI Listing

Smooth muscle hyperplasia of the testicular adnexa: a clinicopathologic study of 12 cases.

Hum Pathol 2020 May 24;99:27-35. Epub 2020 Mar 24.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Smooth muscle hyperplasia of the testicular adnexa (SMH-TA) is a rare mass-forming intrascrotal lesion. Although benign, it can be a diagnostic challenge, as we have seen in our consult practice. Herein, we discuss our experience with these lesions over 14 years. Read More

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http://dx.doi.org/10.1016/j.humpath.2020.03.003DOI Listing
May 2020
2.769 Impact Factor

Arsenite induces testicular oxidative stress in vivo and in vitro leading to ferroptosis.

Ecotoxicol Environ Saf 2020 May 6;194:110360. Epub 2020 Mar 6.

Department of Occupational and Environmental Health, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, People's Republic of China; Dongsheng Lung-Brain Diseases Joint Lab, Chongqing Medical University, Chongqing, 400016, People's Republic of China. Electronic address:

Ferroptosis is a newly identified form of cell death characterized by accumulation of intracellular iron and requirement of lipid peroxidation. However, whether arsenite triggers testicular cell death via ferroptosis remains unclear. In this study, after administrating of adult male mice with 0. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110360DOI Listing

Bilateral spontaneous thrombosis of the pampiniform plexus mimicking incarcerated inguinal hernia: case report of a rare condition and literature review.

Surg Case Rep 2020 Mar 5;6(1):47. Epub 2020 Mar 5.

Department of General Surgery, BSMCH, Bankura, India.

Background: Pampiniform plexus thrombosis is a very rare disease (only less than 25 published cases are available till date), and it is a diagnostic dilemma. The present case is an unusual condition of an elderly gentleman who was finally diagnosed as a case of spontaneous thrombosis of bilateral pampiniform plexus and was managed conservatively. Literature was reviewed to explore potential etiologies and therapeutic strategies. Read More

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http://dx.doi.org/10.1186/s40792-020-00810-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058780PMC

Malignant mesothelioma of the tunica vaginalis testis: a rare case and review of literature.

BMC Cancer 2020 Feb 27;20(1):162. Epub 2020 Feb 27.

Laboratory of Cancer Epidemiology, National Cancer Institute, Vilnius, Lithuania.

Background: Malignant mesothelioma of the tunica vaginalis is a rare tumour which comprises less than 1% of all mesotheliomas.

Case Presentation: 69-years old patient with painful hard mass and hydrocele in the right scrotum to whom a right hydrocelectomy was performed. Any history of scrotal trauma or exposure to asbestos was not present. Read More

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http://dx.doi.org/10.1186/s12885-020-6648-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045691PMC
February 2020
3.362 Impact Factor

Hyponatremia Is Linked to Bone Loss, Osteoporosis, Fragility and Bone Fractures.

Front Horm Res 2019 15;52:49-60. Epub 2019 Jan 15.

Chronic hyponatremia may not cause overt symptoms, and therefore frequently remains untreated. More recently, growing evidence indicate that this condition is not benign, and can lead to unsteady gait, deterioration of bone mass and strength, increased fragility, and increased all-cause mortality. We provided the first evidence for hyponatremia-induced osteoporosis based on markedly reduced bone mineral density and bone structural changes in hyponatremic rats, which is an experimental model of the syndrome of inappropriate antidiuresis (SIAD). Read More

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http://dx.doi.org/10.1159/000493237DOI Listing

Male genital trauma at a level 1 trauma center.

World J Urol 2020 Feb 20. Epub 2020 Feb 20.

Department of Urology, Harborview Medical Center, University of Washington, 325 9th Ave, Box 359868, Seattle, WA, 98104, USA.

Objectives: To describe our experience with men admitted to a tertiary care hospital with genital injury.

Methods: Adult men with injuries of the genitals, admitted to our institution between January 2013 and June 2018, were identified from our institutional trauma registry. Patient charts were queried to extract mechanism, management, follow-up, and complications. Read More

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http://dx.doi.org/10.1007/s00345-020-03115-0DOI Listing
February 2020

Novel therapeutic approaches of tissue engineering in male infertility.

Cell Tissue Res 2020 Apr 11;380(1):31-42. Epub 2020 Feb 11.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Male reproductive organ plays an important role in sperm production, maintenance and entry to the female reproductive tract, as well as generation and secretion of male sex hormones responsible for the health of male reproductive system. The purpose of this paper is to discuss the experimental and clinical evidence on the utilization of tissue engineering techniques in treating male infertility. Tissue engineering (TE) and regenerative medicine have developed new approaches to treat patients with reproductive disorders such as iatrogenic injuries, congenital abnormalities, and trauma. Read More

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http://dx.doi.org/10.1007/s00441-020-03178-wDOI Listing

Paratesticular colon cancer metastasis in an area of remote trauma.

Authors:
Moshe Wald

BMJ Case Rep 2020 Feb 5;13(2). Epub 2020 Feb 5.

Urology, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA

A 53-year-old man with a history of colon adenocarcinoma and remote scrotal trauma resulting in a palpable nodule. Gradual increase in the size of this lesion over the year prior to his presentation to our clinic prompted scrotal ultrasound that demonstrated a 1.1 cm solid lesion, which appeared to arise from the right epididymal tail. Read More

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http://dx.doi.org/10.1136/bcr-2019-233106DOI Listing
February 2020

A systematic review of genitourinary injuries arising from rugby and football.

J Pediatr Urol 2020 Apr 7;16(2):130-148. Epub 2020 Jan 7.

Department of Surgery, University of Toronto, Toronto, Canada; Division of Urology, The Hospital for Sick Children, Toronto, Canada.

Background: Genitourinary injuries in athletes engaging in high-impact sports such as football and rugby may have catastrophic consequences, especially in individuals with pre-existing urologic concerns, such as a solitary kidney.

Objective: To summarize the current literature on football-related or rugby-related genitourinary organ injuries in both adult and pediatric populations in an effort to risk stratify the likelihood of these injuries.

Methods: An independent systematic literature search for records reporting football-related or rugby-related injuries was conducted by a certified librarian and reviewer in March 2019. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.12.019DOI Listing

MRI findings of an atypical testicular epidermoid cyst: A case report.

Medicine (Baltimore) 2020 Jan;99(3):e18818

Department of Ultrasonography, People's Hospital of Long Hua District, Shenzhen, China.

Introduction: Typical testicular epidermoid cysts (TECs) manifestate as a target sign or onion skin sign on ultrasonography and magnetic resonance (MR) imaging. Clinicians are increasingly aware of the imaging characteristics of typical TECs, which allow accurate diagnosis and successful treatment while preserving the testicle, but atypical TECs are likely to be misdiagnosed as a malignant intratesticular neoplasm, leading to complete testicular resection.

Patient Concerns: A 26 year-old male patient complained of a painless enlargement of the left testicle that had been present for 1 month. Read More

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http://dx.doi.org/10.1097/MD.0000000000018818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220063PMC
January 2020

Testicular Rupture Following Blunt Scrotal Trauma.

Case Rep Emerg Med 2019 18;2019:7058728. Epub 2019 Dec 18.

Spectrum Health-Michigan State University Emergency Medicine Residency Program, Grand Rapids, MI, USA.

Testicular rupture after blunt scrotal trauma is characterized by rupture of the tunica albuginea and extrusion of seminiferous tubules. This is a serious injury and appropriate evaluation and management are necessary both for symptom control, but also for preservation of the testicle. Clinical examination of the scrotum following trauma is difficult and may result in incorrect triage of patients for surgical exploration. Read More

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http://dx.doi.org/10.1155/2019/7058728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942712PMC
December 2019

Congenital Spigelian hernia and ipsilateral cryptorchidism: a new syndrome?

Folia Med Cracov 2019 ;59(4):71-78

Department of Internal Medicine, General Hospital of Veria, Veria, Greece.

Spigelian hernia (SH) is a rare ventral interstitial hernia occurring through a defect in the transversus abdominis aponeurosis (Spigelian fascia). Spigelian fascia is found between the lateral border of the rectus abdominis muscle and the semilunar line, which extends from the costal cartilage to the pubic tubercle. In other words, Spigelian line is where the transversus abdominis muscle ends in an aponeurosis characterized by a congenital or acquired defect in the Spigelian aponeurosis. Read More

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http://dx.doi.org/10.24425/fmc.2019.131381DOI Listing

A Chinese herbal prescription Yiqi Jiedu decoction attenuates irradiation induced testis injury in mice.

Biomed Pharmacother 2020 Mar 26;123:109804. Epub 2019 Dec 26.

School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address:

Objective: Yiqi Jiedu (YQJD) decoction is a Chinese herbal prescription, based on an experienced expert of traditional Chinese medicine. It is used for the injuries caused by radiotherapy. The current study was designed to investigate the protective effects of YQJD decoction on radiation damage of testis in mice, and to explore its potential mechanisms. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.109804DOI Listing

Protective Action of Leaves Aqueous Extracts Against Bisphenol A-Caused Testicular Damages.

J Med Food 2020 Jun 20;23(6):600-610. Epub 2019 Dec 20.

Laboratory of Functional Physiology and Valorization of Bio-Resources, Higher Institute of Biotechnology of Beja, University of Jendouba, Beja, Tunisia.

action on the male reproductive system and fertility has not been precisely defined. In this study, the aim was to investigate the ameliorative activity of aqueous extracts (ESAE) on reproductive toxicity associated with oxidative stress induced by bisphenol A (BPA). Wistar rats were used and divided into six groups of animals each; control (0. Read More

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http://dx.doi.org/10.1089/jmf.2019.0170DOI Listing
June 2020
1.699 Impact Factor

The effectiveness of traditional Japanese medicine Goshajinkigan in irradiation-induced aspermatogenesis in mice.

BMC Complement Altern Med 2019 Dec 11;19(1):362. Epub 2019 Dec 11.

Department of Anatomy, Tokyo Medical University, Tokyo, 160-8402, Japan.

Background: Infertility and gonadal dysfunction are well known side-effects by cancer treatment in males. In particularly, chemotherapy and radiotherapy induced testicular damage, resulting in prolonged azoospermia. However, information regarding therapeutics to treat spermatogenesis disturbance after cancer treatment is scarce. Read More

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http://dx.doi.org/10.1186/s12906-019-2786-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907346PMC
December 2019

Pelvic injury is not just pelvic fracture.

BMJ Case Rep 2019 Dec 4;12(12). Epub 2019 Dec 4.

Emergency Department, St George's NHS Trust, London, UK.

Pelvic trauma is complex, most of current work centres around pelvic haemorrhage and fractures. It is important to remember that there is more anatomy in the pelvis than bones and vessels. A 29-year-old male patient was admitted after an Road Traffic Collision (RTC) where his motorbike T-boned a car. Read More

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http://dx.doi.org/10.1136/bcr-2019-232622DOI Listing
December 2019

Degloving injury to groin, scrotum and penis due to low-velocity handlebar injury.

BMJ Case Rep 2019 Nov 25;12(11). Epub 2019 Nov 25.

Paediatric Surgery, John Radcliffe Hospital, Oxford, UK.

Bicycles are a common cause of blunt abdominal trauma causing 5%-14% of injuries. However, impalement or shear injuries from low-velocity mechanism of injury are rare. We report a case of a 14-year-old boy presenting with an extensive left groin injury sustained while cycling one-handed along the pavement at walking pace. Read More

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http://dx.doi.org/10.1136/bcr-2019-231598DOI Listing
November 2019

Intra-Testicular Papaverine Injection for Testicular Salvage after Blunt Testicular Trauma: A Case Report.

Curr Urol 2019 Oct 1;13(2):110-112. Epub 2019 Oct 1.

Department of Urology, Hahnemann University Hospital/Drexel University College of Medicine, Philadelphia, PA, USA.

Blunt trauma is the most common mechanism of injury to the scrotum and testicle. Surgical exploration with primary repair, hematoma evacuation, and de-torsion are common surgical interventions. A 20-year-old male with no previous medical history presented after a high-speed motor vehicle collision. Read More

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http://dx.doi.org/10.1159/000499283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873014PMC
October 2019

Evaluation and Management of Chronic Scrotal Content Pain-A Common Yet Poorly Understood Condition.

Rev Urol 2019 ;21(2-3):74-84

Division of Urology, Rush University Medical Center Chicago, IL.

Chronic scrotal content pain (CSCP) refers to bothersome pain localized to structures within the scrotum that has been present for ≥ 3 months. Etiologies include infection, trauma, and referred pain from the spine, abdomen, and retroperitoneum. However, in many patients there is no obvious identifiable cause. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864917PMC
January 2019

The modern testicular prosthesis: patient selection and counseling, surgical technique, and outcomes.

Asian J Androl 2020 Jan-Feb;22(1):64-69

Department of Urology, University of North Carolina School of Medicine, Chapel Hill, NC 27500-7235, USA.

The testicular prosthesis can be an afterthought for providers when performing an orchiectomy for testicular cancer, torsion, atrophic testis, or trauma. However, data suggest that patients find the offer of a testicular prosthesis and counseling regarding placement to be extremely important from both a pragmatic and a psychosocial perspective. Only two-thirds of men undergoing orchiectomy are offered an implant at the time of orchiectomy and of those offered about one-third move forward with prosthesis placement. Read More

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http://dx.doi.org/10.4103/aja.aja_93_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958971PMC
November 2019

A comparison of clinical outcomes of acute testicular torsion between prepubertal and postpubertal males.

J Pediatr Urol 2019 Dec 6;15(6):610-616. Epub 2019 Aug 6.

Division of Pediatric Urology, Children's Hospital of Wisconsin, Children's Hospital of Wisconsin, 999 N, 92nd Street, Suite 330, Milwaukee, WI, 53226, USA. Electronic address:

Short Introduction/background: Surgical intervention for acute testicular torsion can require either orchiopexy or orchiectomy. The decision of which surgery to perform is dependant on the amount of time that the testicle experienced ischemia and the viability of the testicle after reperfusion.

Objective: It is hypothesized that (1) there is a difference in orchiectomy and orchiopexy rates between prepubertal and postpubertal males with acute testicular torsion and (2) presenting symptoms may vary between the two age groups as prepubertal males may present with atypical symptoms, which could result in delayed presentation and diagnosis. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.07.020DOI Listing
December 2019
1 Read

Role of indoleamine 2,3-dioxygenase in testicular immune-privilege.

Sci Rep 2019 11 4;9(1):15919. Epub 2019 Nov 4.

Universidad de Buenos Aires (UBA), Facultad de Medicina, Departamento de Biología Celular e Histología/Unidad Académica II., Ciudad Autónoma de Buenos Aires, C1121ABG, Argentina.

Male meiotic germ cell including the spermatozoa represent a great challenge to the immune system, as they appear long after the establishment of normal immune tolerance mechanisms. The capacity of the testes to tolerate autoantigenic germ cells as well as survival of allogeneic organ engrafted in the testicular interstitium have led to consider the testis an immunologically privileged site. Disruption of this immune privilege following trauma, tumor, or autoimmune orchitis often results in male infertility. Read More

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http://dx.doi.org/10.1038/s41598-019-52192-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828782PMC
November 2019

Lead-mediated inhibition of lysine acetylation and succinylation causes reproductive injury of the mouse testis during development.

Toxicol Lett 2020 Jan 21;318:30-43. Epub 2019 Oct 21.

Shanghai Key Lab of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:

Lead (Pb), a widespread heavy metal, may induce serious diseases, particularly male reproductive injury. However, the mechanisms by which Pb induces testicular injury remain unclear. In this paper, we established a mouse model of Pb-induced testicular injury via an intraperitoneal injection of lead chloride at a concentration of 1. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.10.012DOI Listing
January 2020
2 Reads

Bilateral testes fractures from blunt scrotal trauma.

Urol Case Rep 2020 Jan 24;28:101026. Epub 2019 Sep 24.

Lahey Hospital & Medical Center, 41 Mall Road, Burlington, MA, 01805, USA.

Management of blunt scrotal trauma is classically centered upon evaluation of potential testicular ruptures to that expedient surgical intervention can be employed. We present a unique case of blunt scrotal trauma causing bilateral testes rupture in order to illustrate the rationale for societal guidelines. We additionally offer discussion of potential sequelae of afflicted patients and a sparingly used technique to salvage a severely injured testis. Read More

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http://dx.doi.org/10.1016/j.eucr.2019.101026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796741PMC
January 2020

Protective efficiency of Ashrasi date palm hydroalcoholic extract against diabetes-induced testicular toxicity: A biochemical and stereological study.

Andrologia 2019 Dec 10;51(11):e13420. Epub 2019 Oct 10.

Fertility & Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

The present study was designed to investigate the protective effects of hydroalcoholic extract of Ashrasi date palm (ADP) on diabetes-induced testicular injuries. Adult male rats were randomly allocated into five groups (n = 8 in each group): 1: control; 2: diabetic; 3: diabetic + 30 mg/kg of ADP extract; 4: diabetic + 90 mg/kg of ADP extract; and 5: diabetic + 270 mg/kg of ADP extract. Diabetes was induced by a single dose of streptozotocin (55 mg/kg) intraperitoneally. Read More

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http://dx.doi.org/10.1111/and.13420DOI Listing
December 2019
1 Read

Directing differentiation of human induced pluripotent stem cells toward androgen-producing Leydig cells rather than adrenal cells.

Proc Natl Acad Sci U S A 2019 11 7;116(46):23274-23283. Epub 2019 Oct 7.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089;

Reduced serum testosterone (T), or hypogonadism, affects millions of men and is associated with many pathologies, including infertility, cardiovascular diseases, metabolic syndrome, and decreased libido and sexual function. Administering T-replacement therapy (TRT) reverses many of the symptoms associated with low T levels. However, TRT is linked to side effects such as infertility and increased risk of prostate cancer and cardiovascular diseases. Read More

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http://dx.doi.org/10.1073/pnas.1908207116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859353PMC
November 2019
4 Reads

Right Testicular Artery Occlusion and Acute Appendicitis by .

Case Rep Surg 2019 27;2019:5670802. Epub 2019 Aug 27.

Universidad Nacional Autónoma de Honduras, Honduras.

is a nematode from the superfamily Metastrongyloidea, whose etymology is "roundworm that lives in blood vessels". This parasite can be found from the southern United States to northern Argentina and southern Brazil. In 1983, Morera and Ruiz published the first case of a testicular artery occlusion by . Read More

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http://dx.doi.org/10.1155/2019/5670802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732605PMC
August 2019
3 Reads

Graviola (Annona muricata) attenuates behavioural alterations and testicular oxidative stress induced by streptozotocin in diabetic rats.

PLoS One 2019 11;14(9):e0222410. Epub 2019 Sep 11.

Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, United States of America.

Oxidative stresses intensify the progression of diabetes-related behavioural changes and testicular injuries. Graviola (Annona muricata), a small tree of the Annonaceae family, has been investigated for its protective effects against diabetic complications, oxidative stress, and neuropathies. This study was planned to investigate the effects of graviola on behavioural alterations and testicular oxidative status of streptozotocin (STZ; 65 mg/kg)-induced diabetic rats. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222410PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738607PMC
April 2020
1 Read
3.234 Impact Factor

Fluted pumpkin seeds protect against busulfan-induced oxidative stress and testicular injuries in adult mice.

Drug Chem Toxicol 2019 Aug 30:1-11. Epub 2019 Aug 30.

Department of Biological Sciences, Redeemer's University , Ede , Osun , Nigeria.

Fluted pumpkin is traditionally claimed to improve fertility health of male adult subjects. This study evaluated the adjuvant protective potential of fluted pumpkin seeds (FPS) extract on the deleterious effects of busulfan on the testes. Tubular germ cell depletion was induced in the testis of mice by administration of busulfan (15 mg/kg body wt. Read More

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http://dx.doi.org/10.1080/01480545.2019.1657885DOI Listing

High prevalence of urogenital infection/inflammation in patients with azoospermia does not impede surgical sperm retrieval.

Andrologia 2019 Nov 27;51(10):e13401. Epub 2019 Aug 27.

Department of Urology, Pediatric Urology and Andrology, Justus Liebig University Giessen, Giessen, Germany.

Considering infection/inflammation to be an important risk factor in male infertility, the aim of this study was to make a comprehensive evaluation of the prevalence of urogenital tract infection/inflammation and its potential impact on sperm retrieval in azoospermic patients. In this prospective study, 71 patients with azoospermia were subjected to an extensive andrological workup including comprehensive microbiological diagnostics (2-glass test, semen, testicular swab and testicular tissue analysis) and testicular biopsy/testicular sperm extraction (TESE). Medical history suggested urogenital tract infection/inflammation in 7% of patients, 11% harboured STIs, 14% showed significant bacteriospermia, 15% had seminal inflammation, 17% fulfilled the MAGI definition, and 27% had relevant pathogens. Read More

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http://dx.doi.org/10.1111/and.13401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147116PMC
November 2019
3 Reads

"The Great Masquerader": Sonographic Pictorial Review of Testicular Tuberculosis and its Mimics.

J Clin Imaging Sci 2019 14;9:27. Epub 2019 Jun 14.

Departments of Radiology, Ohio State University Wexner Medical Center, Columbus, OH, USA.

Testicular tuberculosis (TB) is an uncommon presentation of extrapulmonary TB. Although rare in incidence, it is a great masquerader and should be kept in consideration while assessing focal abnormalities involving the testis. Ultrasound findings alone may be non-specific and mimic other diagnoses including infection, inflammation, tumor, infarct, and trauma. Read More

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http://dx.doi.org/10.25259/JCIS-14-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702864PMC
June 2019
2 Reads

An Experimental Study to Evaluate the Protective Effects of Seed Essential Oil on Diabetes-Induced Testicular Injuries.

Medicina (Kaunas) 2019 Aug 19;55(8). Epub 2019 Aug 19.

Fertility & Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran.

: Diabetes is a chronic metabolic disorder that can effectively influences male reproductive performance. The present study was conducted to investigate the protective effects of essential oil (SL) on diabetes-induced testicular injuries. : Adult male rats were randomly allocated into five groups (n = 8 in each group). Read More

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http://dx.doi.org/10.3390/medicina55080499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722974PMC
August 2019
3 Reads

Role of JNK and ERK1/2 MAPK signaling pathway in testicular injury of rats induced by di-N-butyl-phthalate (DBP).

Biol Res 2019 Aug 6;52(1):41. Epub 2019 Aug 6.

School of Public Health, Beihua University, Jilin, 132013, China.

Background: Di-N-butyl-phthalate (DBP) is an endocrine disrupting substance. We investigated the adverse effect of DBP on testis of male rat and reveal its potential mechanism of MAPK signaling pathway involved this effect in vivo and in vitro. Gonadal hormone, sperm quality, morphological change and the activation status of JNK, ERK1/2 and p38 was determined in vivo. Read More

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http://dx.doi.org/10.1186/s40659-019-0248-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685163PMC
August 2019
2 Reads

Raffia palm (Raphia hookeri) wine extenuates redox imbalance and modulates activities of glycolytic and cholinergic enzymes in hyperglycemia-induced testicular injury in type 2 diabetic rats.

J Food Biochem 2019 03 3;43(3):e12764. Epub 2019 Jan 3.

Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, (Westville Campus), Durban, South Africa.

This study investigated the effects of Raffia palm wine (RPW) on redox imbalance, glycolytic and cholinergic enzymes, and ATPase activities in hyperglycemia-induced oxidative testicular injury. Type 2 diabetes (T2D) was induced in male albino rats (Sprague-Dawley) by first administering 10% fructose solution for 14 days, before injecting with an intraperitoneal injection (40 mg/kg body weight) of streptozotocin. Raffia palm wine was administered to two diabetic groups at 150 and 300 mg/kg body weight (bw), when untreated diabetic group was used as a negative control, and metformin-fed group was served as a positive control. Read More

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http://dx.doi.org/10.1111/jfbc.12764DOI Listing
March 2019
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The Association of Renal Agenesis and Ipsilateral Seminal Vesicle Cyst: Zinner Syndrome Case Report.

Case Rep Urol 2019 23;2019:1242149. Epub 2019 Jun 23.

Department of Urology, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Introduction: Zinner syndrome is a rare congenital malformation characterized by the association of an ipsilateral renal agenesis, ipsilateral seminal vesicle cyst, and ipsilateral ejaculatory duct obstruction. This case is one of the first to be reported in the Kingdom of Saudi Arabia.

Case Presentation: A 20-year-old Saudi male patient presented complaining of chronic left groin pain radiating to the left testis and the medial aspect of the left thigh for the last 6 years. Read More

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http://dx.doi.org/10.1155/2019/1242149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612404PMC
June 2019
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Effects of L-carnitine and betamethasone on ischemia-reperfusion injuries and sperm parameters following testicular torsion in a rat model.

Vet Res Forum 2019 15;10(2):125-132. Epub 2019 Jun 15.

Graduate Student, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.

Testicular torsion is a consequence of spermatic cord twisting which causes progressive damage to the structure of the testis and reduces sperm quality and usually results in infertility. In the present study, with the assumption of the protective effects of L-carnitine and betamethasone against ischemia-reperfusion (IR) injuries, their effects on twisted testicles were evaluated and compared. Twenty Wistar rats were randomly divided into four groups and used in this study. Read More

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http://dx.doi.org/10.30466/vrf.2019.74767.2002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626646PMC
June 2019
4 Reads

The acute scrotum: Frequency and range of etiologies in a Middle Eastern setting.

Urologia 2020 Feb 14;87(1):15-18. Epub 2019 Jul 14.

Department of Radiology, American University of Beirut, Beirut, Lebanon.

Aim: To investigate the frequency of different etiologies of acute scrotal pain in males presenting to the emergency department at American University of Beirut Medical Center in Beirut, Lebanon.

Materials And Methods: In all, 94 patients between the ages 18 and 40 years presenting to the emergency room at American University of Beirut Medical Center with acute scrotum were recruited. The scrotum was inspected with palpation, and Doppler Ultrasound of the testicle was performed by a radiology resident to confirm the diagnosis. Read More

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http://dx.doi.org/10.1177/0391560319858491DOI Listing
February 2020
5 Reads

Comparison of multiple doses of cyclosporine A on germ cell apoptosis and epididymal sperm parameters after testicular ischemia/reperfusion in rats.

Exp Mol Pathol 2019 10 25;110:104271. Epub 2019 Jun 25.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Testicular torsion/detorsion (T/D) is an inflammatory problem in men genital system with infertility effects. Cyclosporine A (CsA) as an immunosuppressant medication, exerts anti-inflammatory properties in tissue injuries. We sought to compare the efficacy of 3 doses of CsA on oxidative stress, apoptosis and epididymal sperm quality after ipsilateral testicular T/D. Read More

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http://dx.doi.org/10.1016/j.yexmp.2019.104271DOI Listing
October 2019
8 Reads