16,491 results match your criteria Testicle Malignant Tumors


Intratesticular leiomyoma: A case report and a literature review.

Int J Surg Case Rep 2020 May 23;71:217-221. Epub 2020 May 23.

Urology Department, Sahloul Hospital, Sousse, Tunisia.

Introduction: Leiomyomas are benign tumors that originate from smooth muscles cells. Intratesticular leiomyoma is a very rare type of benign testicular masses. Through the literature, only 11 cases were reported. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262370PMC

Embryonal carcinoma of an intraabdominal testicular tumor on an undescended testicle: a case report.

Med Pharm Rep 2020 Apr 22;93(2):213-218. Epub 2020 Apr 22.

Department of Medical Imaging, Iuliu Hatieganu University of Medicine and Pharmacy, "Prof. Dr. Octavian Fodor", Regional Institute of Gastroenterology and Hepatology Cluj-Napoca, Romania.

Cryptorchidism, as a singular pathology or associated with other dysgenesis syndromes, is one of the main factors of risk for the development of the testicular tumors. Although there are a great number of cases of undescended testicles that are diagnosed and treated during the first 6-12 months of life, there are rare cases of adults who are undiagnosed and untreated from this anomaly, which can present a high risk of malignancy. In this study we present the case of a 36-year-old patient, diagnosed at puberty with left cryptorchidism, untreated, who also hadevidenced a large intraabdominal tumoral mass associated with it. Read More

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http://dx.doi.org/10.15386/mpr-1293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243893PMC

A case of xanthogranulomatous orchitis and its preoperative diagnostic challenges.

Urol Case Rep 2020 Sep 15;32:101248. Epub 2020 May 15.

Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar.

Xanthogranulomatous orchitis (XGO) is an extremely rare inflammatory disease of the testis which can mimic testicular tumors. We report a 42-year-old man who presented with left scrotal swelling for one-month duration associated with pus discharge from the overlying scrotal skin. Scrotal ultrasonography revealed an atrophic heterogenous left testis with scrotal wall collection. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243048PMC
September 2020

Denial and oncological pathology: Case report of a massive testicular cancer.

Urologia 2020 May 27:391560320921714. Epub 2020 May 27.

Department of Urology, University of Turin, Torino, Italy.

Literature: The cancer of testicles represents 1% of male neoplasms and 5% of urological malignant neoplasm. Its incidence has been growing in Western societies. Cancer of testicles usually presents as an increase of consistence in one testicles and absence of pain, as a casual ultrasound scan finding, or it could be highlighted by a scrotal injury. Read More

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http://dx.doi.org/10.1177/0391560320921714DOI Listing

Incidental Testicular Pathologies in Patients With Idiopathic Hydrocele Testis: Is Preoperative Scrotal Ultrasound Justified?

Anticancer Res 2020 May;40(5):2861-2864

Department of Urology, Medical University Innsbruck, Innsbruck, Austria

Background/aim: Hydrocele testis is a common disease with a prevalence of 1% in adults. Although it can be diagnosed by physical examination, scrotal ultrasound represents a standard diagnostic tool, to exclude underlying pathologies among them testicular or scrotal malignancies.

Patients And Methods: We conducted a retrospective analysis of 156 patients aged between 20 and 60 years who underwent surgical hydrocelectomy between 2003 and 2018. Read More

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http://dx.doi.org/10.21873/anticanres.14261DOI Listing

Partial orchiectomy: The Princess Margaret cancer centre experience.

Urol Oncol 2020 Jun 10;38(6):605.e19-605.e24. Epub 2020 Apr 10.

Division of Urology, Department of Surgery, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, Toronto, ON, Canada. Electronic address:

Introduction: Radical orchiectomy (RO) is the standard treatment for a testis cancer. Organ sparing surgery can be considered in the setting of a solitary functioning testis or bilateral tumors. It has also been suggested as an alternative to RO for small lesions. Read More

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http://dx.doi.org/10.1016/j.urolonc.2020.03.012DOI Listing

Leiomyoma of the testis: case report, review of literature, and discussing the role of contrast-enhanced ultrasound.

Urol Case Rep 2020 Jul 1;31:101168. Epub 2020 Apr 1.

USC Institute of Urology, University of Southern California, USA.

Leiomyomas are benign mesenchymal neoplasms that originate from smooth muscle cells. Leiomyoma of the testis is exceedlingly rare. We present a case demonstrating a 1. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139100PMC

Spermatogonial Stem Cell Culture in Oncofertility.

Urol Clin North Am 2020 May;47(2):227-244

Department of Obstetrics, Gynecology and Reproductive Sciences, Molecular Genetics and Developmental Biology Graduate Program, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, 204 Craft Avenue, Pittsburgh, PA 15213, USA. Electronic address:

Infertility caused by chemotherapy or radiation treatments negatively impacts patient-survivor quality of life. The only fertility preservation option available to prepubertal boys who are not making sperm is cryopreservation of testicular tissues that contain spermatogonial stem cells (SSCs) with potential to produce sperm and/or restore fertility. SSC transplantation to regenerate spermatogenesis in infertile adult survivors of childhood cancers is a mature technology. Read More

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http://dx.doi.org/10.1016/j.ucl.2020.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158865PMC

The role of multiparametric ultrasound in the diagnosis of paediatric scrotal pathology.

Br J Radiol 2020 Jun 23;93(1110):20200063. Epub 2020 Apr 23.

Department of Radiology, King's College Hospital, London. Denmark Hill, London SE5 9RS U.K, United Kingdom.

Multiparametric ultrasound (MPUS), combining conventional techniques (greyscale and colour Doppler ultrasound), ultrasound strain elastography, and contrast-enhanced ultrasound (CEUS), has been successfully used in the assessment of adult scrotal pathology. Contrast-enhanced ultrasound can confidently establish testicular tissue vascularity even in the small-volume paediatric testis. Elastography provides further assessment of tissue stiffness, potentially adding useful diagnostic information. Read More

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http://dx.doi.org/10.1259/bjr.20200063DOI Listing
June 2020
1.533 Impact Factor

Large Cell Calcifying Sertoli Cell Tumor with Macrocalcification in a Partially Resected Testis.

Case Rep Pathol 2020 18;2020:5279013. Epub 2020 Mar 18.

Department of Pathology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Large cell calcifying Sertoli cell tumors (LCCSCTs) are extremely rare, with less than 100 tumors being described to date. Most of the tumors are benign with a few malignant cases, and aggressive behavior is infrequent. These tumors are a type of Sertoli cell tumor, and these tumors comprise less than 0. Read More

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http://dx.doi.org/10.1155/2020/5279013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104315PMC

[Ultrasound characteristics of testicular Leydig cell tumors , , , 1.]

Zhonghua Nan Ke Xue 2019 Apr;25(5):346-350

Department of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.

Objective: To explore the color Doppler ultrasonic characteristics of testicular Leydig cell tumors (LCT) and improve the clinical diagnosis of the disease.

Methods: We retrospectively analyzed 4 cases of testicular LCT diagnosed and treated in our hospital and summarized the experience in the ultrasonic diagnosis of LCT with a review of the relevant literature.

Results: All the 4 testicular LCTs were solitary and quasi-round, 1 in the left and 3 in the right. Read More

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[Clinical characterization of testicular yolk sac tumor in children and adults].

Zhonghua Nan Ke Xue 2019 Feb;25(2):144-149

Department of Urology / Urology Institute of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.

Objective: To compare the clinical characteristics of simple testicular yolk sac tumor (YST) in children with those in adults so as to improve the diagnosis and treatment of the malignance.

Methods: This study included 75 cases of simple testicular YST pathologically confirmed between May 2008 and July 2018, which were divided into groups A (aged <18 years, n = 64) and B (aged ≥18 years, n = 11). We analyzed the clinical data on all the cases and compared the clinical manifestations, laboratory results, pathological findings, clinical stages, treatment methods and prognostic outcomes between the two groups of patients. Read More

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February 2019

[Primary testicular diffuse large B-cell lymphoma: A clinicopathological analysis].

Zhonghua Nan Ke Xue 2019 Feb;25(2):139-143

Department of Pathology, General Hospital of Eastern Theater Command, Nanjing, Jiangsu 210002, China.

Objective: To investigate the clinicopathological features, immunophenotype and treatment of primary testicular diffuse large B-cell lymphoma (DLBCL).

Methods: We retrospectively analyzed the pathomorphological characteristics and immunohistochemical markers of 23 cases of primary testicular DLBCL as well as their clinicopathological features with a review of the relevant literature. The patients were aged 48-76 (mean 61. Read More

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February 2019

Primary testicular diffuse large B-cell lymphoma: Case series.

Medicine (Baltimore) 2020 Mar;99(12):e19463

Department of Pathology.

Rationale: Primary testicular lymphoma (PTL) is a rare type of extranodal non-Hodgkin's lymphoma (NHL). Although data of PTL in patients with diffuse large B-cell lymphoma (DLBCL) are accumulating, there are still patients respond poorly to prognosis.

Patient Concerns: All patients had disease of the DLBCL subtype and those patients had primary involvement of the testis. Read More

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http://dx.doi.org/10.1097/MD.0000000000019463DOI Listing

Systematic analysis of genetic variants in cancer-testis genes identified two novel lung cancer susceptibility loci in Chinese population.

J Cancer 2020 3;11(7):1985-1993. Epub 2020 Feb 3.

Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.

Cancer-testis (CT) genes played important roles in the progression of malignant tumors and were recognized as promising therapeutic targets. However, the roles of genetic variants in CT genes in lung cancer susceptibility have not been well depicted. This study aimed to evaluate the associations between genetic variants in CT genes and lung cancer risk in Chinese population. Read More

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http://dx.doi.org/10.7150/jca.40002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052880PMC
February 2020

Age-Dependent Presentation and Clinical Course of 1465 Patients Aged 0 to Less than 18 Years with Ovarian or Testicular Germ Cell Tumors; Data of the MAKEI 96 Protocol Revisited in the Light of Prenatal Germ Cell Biology.

Cancers (Basel) 2020 Mar 6;12(3). Epub 2020 Mar 6.

ESPED Surveillance Unit, University Düsseldorf, Coordination Center for Clinical Studies, 40225 Düsseldorf, Germany.

Objective: To evaluate prognostic factors in pediatric patients with gonadal germ cell tumors (GCT).

Methods: Patients <18 years with ovarian and testicular GCT (respectively OGCT and TGCT) were prospectively registered according to the guidelines of MAKEI 96. After resection of the primary tumor, patients staged ≥II received risk-stratified cisplatin-based combination chemotherapy. Read More

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http://dx.doi.org/10.3390/cancers12030611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139559PMC

Characterization and distribution of sialic acids in human testicular seminoma.

Acta Histochem 2020 Apr 3;122(3):151532. Epub 2020 Mar 3.

Department of Biosciences and Territory, University of Molise, Contrada Fonte Lappone, 86090 Pesche (Isernia), Italy. Electronic address:

Aberrant content of sialic acids (Sias) has been observed in various human cancer types in different organs. Sias have been implicated in cancerous transformation, invasiveness and metastasis, and in the escaping of cancer cells from immune surveillance. Indeed, Sias are commonly regarded as important biomarkers to distinguish cancer cells from their healthy counterparts. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151532DOI Listing

Prevalence of CD8 cytotoxic lymphocytes in human neoplasms.

Cell Oncol (Dordr) 2020 Jun 5;43(3):421-430. Epub 2020 Mar 5.

Institute of Pathology, Martinistraße 52, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.

Purpose: Immune checkpoint inhibitors have recently been approved by the US FDA as first and/or second line therapy in a subset of cancer types. Recent evidence suggests that the quantity of tumor infiltrating lymphocytes (TILs) influences the likelihood of response to immune checkpoint inhibitors. Here, we set out to assess the density of CD8 lymphocytes in a wide range of different cancer types and subtypes. Read More

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http://dx.doi.org/10.1007/s13402-020-00496-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214387PMC

The clinical features and treatment options of intratesticular epidermoid cysts.

Arch Esp Urol 2020 Mar;73(2):126-131

Department of Urology. Gulhane Training and Research Hospital. Ankara. Turkey.

Objectives: In this study, we aimed to define the clinico-radiological data and treatment options for intratesticular epidermoid cysts (IEC). MATERIALS AND METHODS: We retrospectively reviewed the medical records of the patients that under went surgery for testicular mass between 1995 and 2017. Data of the patients whose histopathological evaluation revealed IEC were recorded. Read More

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Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells.

Clin Cancer Res 2020 Mar 2. Epub 2020 Mar 2.

Division of Infection and Immunity, Henry Wellcome Building, Cardiff University, Cardiff, United Kingdom.

Purpose: Broadly expressed, highly differentiated tumor-associated antigens (TAA) can elicit antitumor immunity. However, vaccines targeting TAAs have demonstrated disappointing clinical results, reflecting poor antigen selection and/or immunosuppressive mechanisms.

Experimental Design: Here, a panel of widely expressed, novel colorectal TAAs were identified by performing RNA sequencing of highly purified colorectal tumor cells in comparison with patient-matched colonic epithelial cells; tumor cell purification was essential to reveal these genes. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-19-3087DOI Listing

HLA class I restricted epitopes prediction of common tumor antigens in white and East Asian populations: Implication on antigen selection for cancer vaccine design.

PLoS One 2020 27;15(2):e0229327. Epub 2020 Feb 27.

Institute of Clinical Oncology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.

Tumor antigens processed and presented by human leukocyte antigen (HLA) Class I alleles are important targets in tumor immunotherapies. Clinical trials showed that presence of CD8+ T cells specific to tumor associated antigens (TAAs) and tumor neoantigens is one of the main factors resulting in tumor regression. Affinity prediction of tumor antigen epitopes to HLA is an important reference index for peptide selection, which is highly individualized. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229327PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046239PMC

Man With Double Vision and a Swollen Testicle.

Ann Emerg Med 2020 03;75(3):369-399

Department of Emergency Medicine, University of Iowa, Iowa City, IA.

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http://dx.doi.org/10.1016/j.annemergmed.2019.09.011DOI Listing

Meningothelial Meningioma Component in a Prepubertal Testicular Teratoma.

Case Rep Pathol 2020 20;2020:6495321. Epub 2020 Jan 20.

Department of Paediatric Surgery, AIIMS, Patna, India.

Teratomas are nonseminomatous germ cell tumors composed of elements derived from more than one germinal layers (endoderm, mesoderm, and ectoderm). Malignant transformation of teratoma in the testis is well known; however, benign somatic neoplasm arising in a testicular teratoma is a rare occurrence. We report a case of meningothelial variant of meningioma arising in a pure and mature teratoma of the testis in a 5-year-old boy. Read More

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http://dx.doi.org/10.1155/2020/6495321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995479PMC
January 2020

Therapeutic strategies for uncommon testis cancer histologies: teratoma with malignant transformation and malignant testicular sex cord stromal tumors.

Transl Androl Urol 2020 Jan;9(Suppl 1):S91-S103

Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Testicular cancer is the most common solid malignancy in male adolescents and young adults, with germ cell derived seminomas and non-seminomas being by far the most common histologies. Teratoma with somatic-type malignancy is a rare chemo-resistant phenotype of testis cancer associated with poor prognosis in patients with advanced stage disease. Malignant gonadal-stromal tumors comprise 5% of testicular neoplasms and approximately 10% are malignant and considered chemo-radiation resistant. Read More

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http://dx.doi.org/10.21037/tau.2019.09.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995843PMC
January 2020

Testis-preserving strategies in testicular germ cell tumors and germ cell neoplasia .

Transl Androl Urol 2020 Jan;9(Suppl 1):S24-S30

Department of Urology, Uro-Oncology, Robot Assisted and Reconstructive Urologic Surgery, University Hospital of Cologne, Cologne, Germany.

Testicular germ cell tumors (TGCT) are rare malignancies which affect young adults and adolescents between the ages of 15 and 40 years. In suspected malignant TGCT, the treatment of choice is radical orchiectomy. However, in specific cases this routine surgical approach has been challenged in favor of an organ-preserving approach with comparable oncological outcome. Read More

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http://dx.doi.org/10.21037/tau.2019.07.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995842PMC
January 2020

Predictors of venous thromboembolism development before and during chemotherapy for advanced germ cell tumor.

Jpn J Clin Oncol 2020 Mar;50(3):338-343

Department of Urology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

Objective: We retrospectively analyzed the incidence and localization of venous thromboembolism in patients undergoing chemotherapy for advanced germ cell tumor and separately evaluated the risk factors for venous thromboembolism development before and during chemotherapy.

Methods: We included 121 patients treated with cisplatin-based chemotherapy between 2005 and 2018. Venous thromboembolism was defined as venous thrombosis diagnosed using radiological imaging with or without thromboembolic symptoms. Read More

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http://dx.doi.org/10.1093/jjco/hyz177DOI Listing

Non seminomatous mixed germ cell tumor of the testis with predominant component of somatic type malignancy (Rhabdomyosarcoma) - A rare occurrence.

Indian J Pathol Microbiol 2020 Jan-Mar;63(1):125-127

Department of Histopathology, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India.

Testicular germ cell tumors (GCT) are a diverse group of neoplasms, broadly divided into seminomatous and non seminomatous types, with varying histomorphology. Mixed germ cell tumors express more than one germ cell component. Somatic type malignancy occurring in testicular GCT is rare. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_796_18DOI Listing
February 2020

Sciatic pain by neurolymphomatosis as initial presentation of disseminated diffuse large B cell lymphoma involving the testis and the CNS.

Hematol Oncol 2020 Apr 5;38(2):197-200. Epub 2020 Feb 5.

Oncology Institute of Southern Switzerland (IOSI), Medical Oncology, Imaging Institute of Southern Switzerland, Bellinzona, Switzerland.

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http://dx.doi.org/10.1002/hon.2698DOI Listing

The role of the cancer testis antigen PRAME in tumorigenesis and immunotherapy in human cancer.

Cell Prolif 2020 Mar 5;53(3):e12770. Epub 2020 Feb 5.

Departmant of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Preferentially expressed antigen in melanoma (PRAME), which belongs to the cancer/testis antigen (CTA) gene family, plays a pivotal role in multiple cellular processes and immunotherapy response in human cancers. PRAME is highly expressed in different types of cancers and is involved in cell proliferation, apoptosis, differentiation and metastasis as well as the outcomes of patients with cancer. In this review article, we discuss the potential roles and physiological functions of PRAME in various types of cancers. Read More

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http://dx.doi.org/10.1111/cpr.12770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106952PMC

[Testicular tumors in prepubertal boys-organ preservation possible more often than expected].

Urologe A 2020 Mar;59(3):278-283

Zentrum für Kinder‑, Jugend- und rekonstruktive Urologie, Medizinische Fakultät Mannheim, der Universität Heidelberg, Universitätsklinikum Mannheim GmbH, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland.

In prepubertal boys, testicular tumors are rare with an incidence between 2 and 5/million. In contrast to testicular tumors in adolescents and adults, more than 2/3 of these tumors are benign. Unfortunately, in Germany in most cases, only malignant tumors (usually yolk sac tumors) are reported to the study center (MAKEI IV and now V). Read More

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http://dx.doi.org/10.1007/s00120-020-01120-0DOI Listing

MRI findings of an atypical testicular epidermoid cyst: A case report.

Medicine (Baltimore) 2020 Jan;99(3):e18818

Department of Ultrasonography, People's Hospital of Long Hua District, Shenzhen, China.

Introduction: Typical testicular epidermoid cysts (TECs) manifestate as a target sign or onion skin sign on ultrasonography and magnetic resonance (MR) imaging. Clinicians are increasingly aware of the imaging characteristics of typical TECs, which allow accurate diagnosis and successful treatment while preserving the testicle, but atypical TECs are likely to be misdiagnosed as a malignant intratesticular neoplasm, leading to complete testicular resection.

Patient Concerns: A 26 year-old male patient complained of a painless enlargement of the left testicle that had been present for 1 month. Read More

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http://dx.doi.org/10.1097/MD.0000000000018818DOI Listing
January 2020

Paratesticular Mesenchymal Malignancies: A Single-Center Case Series, Clinical Management, and Review of Literature.

Integr Cancer Ther 2020 Jan-Dec;19:1534735419900554

Sant'Orsola-Malpighi Hospital, Bologna, Italy.

Primary soft tissue sarcomas arising from the male urinary and genital tract are rare tumors, only accounting for 1% to 2% of all malignancies of the genitourinary tract. Clinical management of advanced disease is lacking in standardized recommendations due to the rarity of the disease. To date, complete and extensive surgery represents the only curative and standardized approach for localized disease, while the impact of retroperitoneal lymphadenectomy and adjuvant treatments on clinical outcomes are still unclear. Read More

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http://dx.doi.org/10.1177/1534735419900554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050957PMC

[Oncofertility and breast cancer].

Bull Cancer 2019 Dec;106(12S1):S43-S52

Service de biologie de la reproduction - CECOS, hôpital Tenon, 75020 Ap-HP, Paris, France.

Over the past decades, progresses in oncology have improved the recovery rates after numerous malignant diseases, including breast cancer, that strike young adults in childbearing age. Quality of life of young cancer survivors has become a major issue. However, anticancer therapies can have a detrimental impact on fertility. Read More

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http://dx.doi.org/10.1016/S0007-4551(20)30047-3DOI Listing
December 2019

Long-Term Oncologic Outcomes after Primary Retroperitoneal Lymph Node Dissection: Minimizing the Need for Adjuvant Chemotherapy.

J Urol 2020 Jan 31:101097JU0000000000000792. Epub 2020 Jan 31.

Department of Urology, Indiana University, Indianapolis, Indiana.

Purpose: We analyzed the oncologic outcomes of men undergoing primary retroperitoneal lymph node dissection and characterized the use of adjuvant chemotherapy and template dissections.

Materials And Methods: Retrospective review of the Indiana University testis cancer database identified patients who underwent primary retroperitoneal lymph node dissection between January 2007 and December 2017. Patients and providers were contacted to obtain information regarding adjuvant therapy, recurrence and survival. Read More

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http://dx.doi.org/10.1097/JU.0000000000000792DOI Listing
January 2020

Differential Expression of Cancer Testis Antigens on Lentigo Maligna and Lentigo Maligna Melanoma.

Am J Dermatopathol 2020 Jan 14. Epub 2020 Jan 14.

Department of Dermatology, Netherlands Institute for Pigment Disorders, Amsterdam UMC, Amsterdam Infection & Immunity Institute, Cancer Center Amsterdam, University of Amsterdam, Amsterdam, the Netherlands.

The cancer/testis antigens (CTA) are a group of antigens expressed on germ cells of healthy testis and malignant tumors. We studied whether CTA are present on lentigo maligna (LM) and LM melanoma (LMM) samples. Immunohistochemical expression of a panel of CTA (MAGE-A1, A2- A3, NY-ESO-1, PRAME, SSX-2, and a MAGE-A antibody reactive with -A1, -A2, -A3, -A4, -A6, -A10, and -A12) was investigated in formalin-fixed paraffin-embedded samples from LMM (n = 20), LM (n = 8), chronically sun-exposed skin (n = 7), and healthy skin (n = 7). Read More

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http://dx.doi.org/10.1097/DAD.0000000000001607DOI Listing
January 2020

The investigation of the antitumoral effect of Cornus mas L in mice with ehrlich solid tumor.

Bratisl Lek Listy 2020 ;121(1):22-30

Aim: Cornus mas L is commonly used due to its anti-inflammatory, anti-carcinogenic and anti-oxidant properties. In the study, the effects of C. mas L extract on a solid tumor were examined in the Ehrlich solid tumor model developed in Balb/C type mice. Read More

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http://dx.doi.org/10.4149/BLL_2020_004DOI Listing
February 2020

Intratumoral heterogeneity and clonal evolution in liver cancer.

Nat Commun 2020 01 15;11(1):291. Epub 2020 Jan 15.

Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Clonal evolution of a tumor ecosystem depends on different selection pressures that are principally immune and treatment mediated. We integrate RNA-seq, DNA sequencing, TCR-seq and SNP array data across multiple regions of liver cancer specimens to map spatio-temporal interactions between cancer and immune cells. We investigate how these interactions reflect intra-tumor heterogeneity (ITH) by correlating regional neo-epitope and viral antigen burden with the regional adaptive immune response. Read More

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http://dx.doi.org/10.1038/s41467-019-14050-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962317PMC
January 2020

Rare benign and malignant testicular lesions: histopathology and management.

Curr Opin Urol 2020 Mar;30(2):235-244

Department of Urology.

Purpose Of Review: The presence of vascular solid tumors within the testicle is considered to be malignant until proven otherwise. However, it is prudent for clinicians to be aware of rare benign and malignant intratesticular lesions as management can differ from the established treatment algorithms for germ-cell tumors.

Recent Findings: Utilizing certain histopathologic findings can assist with the diagnosis of rare testis tumors. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000715DOI Listing

Tazarotene-Induced Gene 1 (TIG1) Interacts with Serine Protease Inhibitor Kazal-Type 2 (SPINK2) to Inhibit Cellular Invasion of Testicular Carcinoma Cells.

Biomed Res Int 2019 25;2019:6171065. Epub 2019 Nov 25.

Department of Research, Taipei Tzuchi Hospital, The Buddhist Tzuchi Medical Foundation, New Taipei City 231, Taiwan.

Tazarotene-induced gene 1 (TIG1) encodes a protein that is a retinoid-regulated tumor suppressor. TIG1 is expressed in most normal tissues, and downregulation of TIG1 expression in multiple cancers is caused by promoter hypermethylation. Kazal-type serine protease inhibitor-2 (SPINK2) is a serine protease inhibitor, and the SPINK protein family has been shown to inhibit the expression of urokinase-type plasminogen activator (uPA). Read More

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http://dx.doi.org/10.1155/2019/6171065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899300PMC

Variation of Gonadal Dysgenesis and Tumor Risk in Patients With 45,X/46,XY Mosaicism.

Urology 2020 Mar 27;137:157-160. Epub 2019 Dec 27.

Department of Pathology, Osaka Women's and Children's Hospital, Osaka, Japan.

Objective: To describe the gonadal features of patients with 45,X/46,XY mosaicism, and to evaluate the prevalence of gonadal tumor in different phenotypes.

Materials And Methods: The medical records of consecutive patients with 45,X/46,XY karyotype or its variants who had undergone gonadal biopsy or gonadectomy at a single institute between 1996 and 2017 were retrospectively reviewed.

Results: Of 34 patients with 45,X/46,XY mosaicism, a unilateral dysgenetic testis and a contralateral streak gonad was detected in 20 patients (59%), bilateral streak gonads in 9 (26%), and bilateral dysgenetic testes in 5 (15%). Read More

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http://dx.doi.org/10.1016/j.urology.2019.12.014DOI Listing

[Management of residual masses of testis germ cell tumors].

Bull Cancer 2020 Feb 24;107(2):215-223. Epub 2019 Dec 24.

Hôpital Nord, service d'urologie, avenue Albert-Raimond, 42270 Saint-Priest-en-Jarez, France.

A residual mass (RM) is an abnormal image with a transverse axis of more than 1cm trans that remains visible on the CT scan performed after chemotherapy for metastatic germ cell tumors. Their management depends on the histology of the initial tumor. In the case of a non-seminomatous germ cell tumor, all residual lesions must be resected if the tumor markers are negative. Read More

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http://dx.doi.org/10.1016/j.bulcan.2019.10.010DOI Listing
February 2020

A Novel Tissue and Stem Cell Specific TERF1 Splice Variant Is Downregulated in Tumour Cells.

Int J Mol Sci 2019 Dec 20;21(1). Epub 2019 Dec 20.

Department of Urology, Ulm University Hospital, 89081 Ulm, Germany.

In this study, we describe the identification of a novel splice variant of TERF1/PIN2, one of the main components of the telomeric shelterin complex. This new splice variant is identical to TERF1, apart from a 30 amino acid internal insertion near to the C-terminus of TERF1. Based on genome comparison analyses and RNA expression data, we show that this splice variant is conserved among hominidae but absent from all other species. Read More

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http://dx.doi.org/10.3390/ijms21010085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981981PMC
December 2019

Lymphomas arising in immune-privileged sites: insights into biology, diagnosis, and pathogenesis.

Virchows Arch 2020 May 20;476(5):647-665. Epub 2019 Dec 20.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.

Session 2 of the 2018 European Association of Hematopathology/Society for Hematopathology Workshop focused on lymphomas arising in immune-privileged sites: both lymphomas arising in the traditionally described "immune sanctuary" sites of the central nervous system (CNS) and testes, as well as those arising at sites of local immune privilege. Primary CNS large B cell lymphoma and primary testicular large B cell lymphoma were discussed, and the biology of these unique tumors was highlighted by several cases showing the classic mutation profile including MYD88 L265P and CD79B. The tendency of these tumors to involve both the CNS and testis was also reinforced by several cases. Read More

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http://dx.doi.org/10.1007/s00428-019-02698-3DOI Listing

Cannabinoid Receptors Signaling in the Development, Epigenetics, and Tumours of Male Germ Cells.

Int J Mol Sci 2019 Dec 18;21(1). Epub 2019 Dec 18.

Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133 Rome, Italy.

Endocannabinoids are natural lipid molecules whose levels are regulated by specific biosynthetic and degradative enzymes. They bind to and activate two main cannabinoid receptors type 1 (CB) and type 2 (CB), and together with their metabolizing enzymes form the "endocannabinoid system" (ECS). In the last years, the relevance of endocannabinoids (eCBs) as critical modulators in various aspects of male reproduction has been pointed out. Read More

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http://dx.doi.org/10.3390/ijms21010025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981618PMC
December 2019

Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.

J Urol 2020 05 17;203(5):949-956. Epub 2019 Dec 17.

Department of Urology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Purpose: Leydig cell tumors are rare but they are the most common nongerm cell testicular tumors. Only limited evidence exists for reliably differentiating between benign and malignant Leydig cell tumors and for optimally managing the different types and stages of this rare disease. In this review we synthesize the available evidence on the clinical presentation and clinicopathological characteristics associated with Leydig cell tumor malignancy and management. Read More

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http://dx.doi.org/10.1097/JU.0000000000000705DOI Listing

Rare multifocal manifestation of solitary extramedullary plasmacytomas.

BMJ Case Rep 2019 Dec 15;12(12). Epub 2019 Dec 15.

Radiology, King's College Hospital NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1136/bcr-2019-232273DOI Listing
December 2019

TEX19 promotes ovarian carcinoma progression and is a potential target for epitope vaccine immunotherapy.

Life Sci 2020 Jan 13;241:117171. Epub 2019 Dec 13.

Department of Pharmacology, School of Pharmacy, China Medical University, No.77, Puhe Road, Shenyang North New Area, Shenyang, Liaoning 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, No.77, Puhe Road, Shenyang North New Area, Shenyang, Liaoning 110122, PR China; Liaoning Cancer immune peptide drug Engineering Technology Research Center, China Medical University, No.77, Puhe Road, Shenyang North New Area, Shenyang, Liaoning 110122, PR China; Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, China Medical University, No.77, Puhe Road, Shenyang North New Area, Shenyang, Liaoning 110122, PR China. Electronic address:

Aims: Testis Expressed 19 (TEX19) is one of cancer/testis antigens identified in recent years and is related to the oncogenesis and progress of several cancers. This study aimed to reveal the role of TEX19 in ovarian cancer (OC) and searched for potential candidate epitope peptides of TEX19 to facilitate clinical application.

Main Methods: TEX19 levels were evaluated by immunohistochemistry (IHC) in 98 human ovarian tissue samples. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.117171DOI Listing
January 2020

Intrascrotal lipoblastoma in adulthood.

BMJ Case Rep 2019 Dec 10;12(12). Epub 2019 Dec 10.

Pathology, Instituto Português de Oncologia de Coimbra Francisco Gentil EPE, Coimbra, Portugal.

This case report describes the case of a 37-year-old man that noticed an intrascrotal right mass with 1 month of evolution. During physical exam presented with a large mass at the inferior portion of the right testicle, clearly separated from the testicle, with a tender consistency and mobile. An ultrasound was performed that showed a solid and subcutaneous nodular lesion, extra testicular, heterogeneous, measuring 7. Read More

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http://dx.doi.org/10.1136/bcr-2019-231320DOI Listing
December 2019

Predominance of Granular Cell Tumours among Testicular Tumours of Rabbits (Oryctolagus cuniculi f. dom.).

J Comp Pathol 2019 Nov 1;173:24-29. Epub 2019 Nov 1.

Department of Pathology, University of Veterinary Medicine, Hannover, Germany. Electronic address:

Testicular neoplasms are reported rarely in pet and laboratory rabbits (Oryctolagus cuniculi f. dom.), with interstitial cell tumours being the most commonly described testicular neoplasm. Read More

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http://dx.doi.org/10.1016/j.jcpa.2019.09.012DOI Listing
November 2019

Malignant leydig cell tumor in a 91-year-old man: Case report.

Int Braz J Urol 2019 Nov-Dec;45(6):1260-1265

Departamento de Urologia da Santa Casa de Misericórdia de Ribeirão Preto, São Paulo, Brasil.

Testicle tumors are a rare entity among men population, accounting for only 1-1.5% of all can-cers among men. The stromal tumors of the sexual cord correspond just 4% of all testicular cancers. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0720DOI Listing
January 2020