16,047 results match your criteria Testicle Malignant Tumors


[Organ-sparing partial orchietectomy for testicular adenomatoid tumor].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):365-368

Department of Urology, Peking University Third Hospital, Beijing 100191, China.

Objective: The incidence of testicular tumors is relatively low which are mainly malignant, so the main way to treat testicular tumors is radical testicular resection. Testicular adenomatoid tumor is a rare testicular benign tumor, but is easily misdiagnosed as malignant tumors with removal of organs. This article aims to explore the clinical features of testicular adenomatoid tumor and its treatment. Read More

View Article

Download full-text PDF

Source
April 2019
1 Read

Clinical Management and Outcome in Extreme Retroperitoneal Growing Teratoma Syndrome of Testicular Origin - Clinical Management and Effect of the Treatment.

Klin Onkol 2019 ;32(2):129-132

Background: Growing teratoma syndrome (GTS) is an uncommon clinical finding in patients treated for testicular cancer. It is diagnosed during or after chemotherapy as an expanding tumour mass not responding to the treatment while the serum tumour markers are within the normal range. Pathological evaluation of resected tissue confirms the structures of benign mature teratoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14735/amko2019129DOI Listing
January 2019

<Editors' Choice> Meddling with meddlers: curbing regulatory T cells and augmenting antitumor immunity.

Nagoya J Med Sci 2019 Feb;81(1):1-18

Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

CD4 regulatory T cells (Tregs) expressing the transcription factor forkhead box P3 (FoxP3) play an important role in self-tolerance and immune homeostasis. Tregs have evolved to protect the host from aberrant immune responses against self-components and collateral damages occurring in the process of defense against invading pathogens by softening immune responses. However, they turned to be a scourge in malignant tumors by not only allowing and promoting tumor growth but also suppressing effective antitumor actions, both inherent (host's immune surveillance) and extrinsic (anticancer therapy). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18999/nagjms.81.1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433633PMC
February 2019

Testis-sparing surgery for testicular masses: current perspectives.

Minerva Urol Nefrol 2019 04 5. Epub 2019 Apr 5.

Urology Department, University Clinics of Brussels, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

Introduction: Males who present with a palpable testis nodule are likely to have malignant germ cell tumor in > 90% of cases. Therefore radical orchiectomy remains the standard of care for intratesticular tumors. However, due to the recent developments of high-frequency probes in ultrasonography, the incidence of detecting a small non-palpable testis tumors is higher and higher. Read More

View Article

Download full-text PDF

Source
https://www.minervamedica.it/index2.php?show=R19Y9999N00A190
Publisher Site
http://dx.doi.org/10.23736/S0393-2249.19.03315-0DOI Listing
April 2019
6 Reads

Immunolocalization of DMRTB1 in human testis with normal and impaired spermatogenesis.

Andrology 2019 Mar 28. Epub 2019 Mar 28.

Institute for Anatomy, University of Veterinary Medicine Hannover, Hannover, Germany.

Background: The transcription factor DMRTB1 plays a pivotal role in coordinating the transition between mitosis and meiosis in murine germ cells. No reliable data are available for human testis.

Objectives: The present study aims to examine the testicular expression pattern of DMRTB1 in men showing normal and impaired spermatogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/andr.12617DOI Listing
March 2019
1 Read

Undescended testis.

BMJ 2019 03 25;364:l926. Epub 2019 Mar 25.

Paediatric Urology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmj.l926DOI Listing

Testicular pain as an atypical presentation of sarcoidosis.

Ann R Coll Surg Engl 2019 Apr 25;101(4):e99-e101. Epub 2019 Mar 25.

University College London Hospitals NHS Foundation Trust , UK.

Sarcoidosis is a systemic granulomatous disease, with genitourinary tract involvement being very rare (0.2% of all sarcoidosis cases). Genitourinary sarcoidosis may present with a scrotal mass with or without testicular pain, often mimicking epididymo-orchitis or malignancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1308/rcsann.2019.0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432954PMC
April 2019
3 Reads

Spectrum of urogenital tumors in males in Sub-Himalayan region: An institutional experience.

J Cancer Res Ther 2019 Mar;15(Supplement):S82-S86

Department of Urology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

Aims: The clinical presentation and frequency of urogenital tumors varies in different regions of the world. This study was undertaken to analyze the frequency, clinical presentation, and the histopathological spectrum of the various male urogenital tumors diagnosed over a period of 3 years in a tertiary care institute.

Materials And Methods: Three-year data were collected from the histopathology laboratory, which included all the cases of male urogenital tumors which were diagnosed histopathologically between November 2012 and October 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jcrt.JCRT_565_17DOI Listing
March 2019
2 Reads

Poor prognosis of retroperitoneal mixed extragonadal germ cell tumors in an HIV-infected man with severe immunosuppression and bilateral cryptorchidism: a case report.

Authors:
Ruili Li Hongjun Li

BMC Cancer 2019 Mar 18;19(1):244. Epub 2019 Mar 18.

Department of Radiology, Beijing Youan Hospital, Capital Medical University, No. 8, Xi Tou Tiao, Youanmen Wai, Fengtai District, Beijing, 100069, China.

Background: Nonseminomatous germ cell tumors (NSGCTs) represent one of the main groups of germ cell tumors (GCTs), and they have a more invasive course than seminomatous GCTs. Human immunodeficiency virus (HIV) positivity is considered to be a risk factor for testicular seminoma patients, but reports about HIV-infected individuals with NSGCTs are rare.

Case Presentation: We report a case of a retroperitoneal mixed extragonadal germ cell tumor in an HIV-infected man who has been diagnosed with bilateral cryptorchidism since birth. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12885-019-5456-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423750PMC
March 2019
1 Read

High-frequency ultrasonography and contrast-enhanced ultrasound for the evaluation of testicular capillary hemangioma: A case report.

Medicine (Baltimore) 2019 Mar;98(11):e14779

Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, China.

Rationale: Testicular capillary hemangioma (TCH) is a rare benign tumor of the testis. To the authors' knowledge, there is currently only a few literatures describing the use of contrast-enhanced ultrasound (CEUS) to diagnose TCH. Accurate preoperative diagnosis of benign tumors can avoid orchiectomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426614PMC
March 2019
2 Reads

Immunohistochemistry for TFE3 lacks specificity and sensitivity in the diagnosis of TFE3-rearranged neoplasms: a comparative, two-laboratory study.

Hum Pathol 2019 Mar 6. Epub 2019 Mar 6.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address:

TFE3 rearrangements are characteristic of alveolar soft part sarcomas (ASPS), Xp11.2 translocation renal cell carcinomas (Xp11-RCC), and other rare tumors. Immunohistochemistry for TFE3 protein has been considered by some to be a reliable surrogate for TFE3 molecular studies, although others disagree. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.humpath.2019.02.008DOI Listing
March 2019
2 Reads

[Mucosal melanoma primary and metastatic cases with urogenital localization in our department].

Orv Hetil 2019 Mar;160(10):378-385

Urológiai Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Üllői út 78/B, 1082.

Introduction: Both primary and metastatic cases of mucosal melanoma in urogenital localization are rare tumors. Only 4-5% of all primary melanomas do not arise from the skin. Extracutaneous melanomas have a complex clinical presentation, but these aggressive tumors have a poor prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1556/650.2019.31303DOI Listing
March 2019
3 Reads

Primary High-grade Peripheral T-cell Lymphoma of the Testis Clinically Confused With Scrotal Abscess.

Urology 2019 May 26;127:e3-e5. Epub 2019 Feb 26.

Urology, Dubai Hospital, Dubai, United Arab Emirates.

Testicular T-cell lymphomas are rare and heterogeneous. Their rarity, nonspecific clinical and radiologic features, histomorphologic heterogeneity, and aberrant immunohistochemical expression may impose diagnostic difficulties for clinicians and pathologists. They may mimic germ cell neoplasms, infectious orchitis, and scrotal abscess. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urology.2019.02.019DOI Listing
May 2019
2 Reads

A rare testicular tumor: primary carcinoid tumor.

Tumori 2019 Feb 24:300891619832263. Epub 2019 Feb 24.

1 Department of Pathology, University Teaching Hospital of Lomé, Togo.

Background:: Primary carcinoid tumors are rare and constitute 0.23% of all testicular tumors. We report a case of primary carcinoid tumor of testicular localization, with a review of the literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0300891619832263DOI Listing
February 2019
2 Reads

Unclassified sex cord/gonadal stromal testis tumor with a "pure" spindle cell component: a case report.

Pathologica 2018 Dec;110(4):302-306

Division of Urology Hospital "San Giacomo", Novi Ligure (AL).

Unclassified sex cord/gonadal stromal tumors (SCSTs) composed predominantly of spindle cells are rare. Very few cases have been documented to date. Here, we report a case of "pure" spindle cell tumor of the left testis in a 83-year old man whose morphological and immunohistochemical findings were consistent with a diagnosis of unclassified SCST and review the literature. Read More

View Article

Download full-text PDF

Source
December 2018
5 Reads

The relationship between cannabis and male infertility, sexual health, and neoplasm: a systematic review.

Andrology 2019 Mar 15;7(2):139-147. Epub 2019 Feb 15.

Department of Urology, University of Washington Medical Center, Seattle, WA, USA.

Background: In the United States of America (USA), cannabis is legal in 28 states for medical purposes and 8 states for recreational use. In 2016, the legal marijuana industry reached nearly $7 billion in sales in the USA alone. Although consumption continues to increase, the medical effects of marijuana remain understudied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/andr.12585DOI Listing
March 2019
1 Read

A man with a painful and swollen left testicle.

BMJ 2019 Feb 14;364:l334. Epub 2019 Feb 14.

University Hospital Monklands, Airdrie, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmj.l334DOI Listing
February 2019
1 Read

Multiple Myeloma of Testes and Spermatic Cord on 18F-FDG PET/CT.

Clin Nucl Med 2019 Apr;44(4):297-298

Health Science North, Subbury, Ontario, Canada.

Extramedullary multiple myeloma (EM) has negative prognostic implications on the overall survival as well as progression-free survival. Testis is a rare site of EM, which can be a part of diffuse involvement in multiple myeloma or a site of recurrence in patients with remission. We present a case of EM of testes and left spermatic cord in an 80-year-old man who presented with painless progressive enlargement of the scrotum. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLU.0000000000002462DOI Listing
April 2019
6 Reads

Adenocarcinoma of the Rete Testis: Clinicopathologic and Immunohistochemical Characterization of 6 Cases and Review of the Literature.

Am J Surg Pathol 2019 May;43(5):670-681

Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.

Adenocarcinoma of the rete testis is rare and its etiological and pathologic characteristics are not well studied. We therefore investigated the clinical, morphologic, and immunohistochemical features of 6 cases diagnosed at our institution and conducted a detailed review of the literature. The mean age was 64 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAS.0000000000001219DOI Listing
May 2019
12 Reads

Testicular Mesothelioma: An Analysis of Epidemiology, Patient Outcomes, and Prognostic Factors.

Urology 2019 Apr 19;126:140-144. Epub 2019 Jan 19.

Institute of Urology, University of Southern California, Los Angeles, CA; USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA. Electronic address:

Objectives: To characterize demographic features, clinical characteristics, and oncologic outcomes of mesothelioma of the testis.

Methods: A population based search was performed using the National Cancer Institute's SEER 18 database. Patients diagnosed with malignant mesothelioma of the male genital organs from 1973 to 2015 were identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urology.2019.01.009DOI Listing
April 2019
2 Reads

Expression of cancer-testis antigens in esophageal cancer and their progress in immunotherapy.

J Cancer Res Clin Oncol 2019 Feb 17;145(2):281-291. Epub 2019 Jan 17.

Department of Oncology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, 430030, Hubei, China.

Purpose: Esophageal cancer is a common disease in China with low survival rate due to no obvious early symptoms and lack of effective screening strategies. Traditional treatments usually do not produce desirable results in patients with advanced esophageal cancer, so immunotherapy which relies on tumor-related antigens is needed to combat low survival rates effectively. Cancer-testis antigens (CTA), a large family of tumor-related antigens, have a strong in vivo immunogenicity and tumor-restricted expressing patterns in normal adult tissues. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00432-019-02840-3
Publisher Site
http://dx.doi.org/10.1007/s00432-019-02840-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373256PMC
February 2019
11 Reads

The role of tumor size, ultrasonographic findings, and serum tumor markers in predicting the likelihood of malignant testicular histology.

Asian J Androl 2019 Mar-Apr;21(2):196-200

Department of Urology, Peking University First Hospital, Beijing 100034, China.

The clinical predictive factors for malignant testicular histology remain unclear because of the low prevalence. Therefore, the aim of this study was to investigate predictors of malignant histology for testicular masses and decide more testis-sparing surgeries before surgery. This retrospective study enrolled 325 consecutive testicular mass patients who underwent radical orchiectomy (310/325) or testicular preserving surgery (15/325) from January 2001 to June 2016. Read More

View Article

Download full-text PDF

Source
http://www.ajandrology.com/preprintarticle.asp?id=250280
Publisher Site
http://dx.doi.org/10.4103/aja.aja_119_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413548PMC
January 2019
8 Reads

Primary Carcinoid Tumor of the Testis: A Case Report and Review of the Literature.

Case Rep Urol 2018 3;2018:3614387. Epub 2018 Dec 3.

University of Balamand, Saint George Hospital University Medical Center, Department of Urology, Beirut 1100 2807, Lebanon.

Carcinoid tumors usually arise in the gastrointestinal tract. Immunocytohistochemical and radiologic studies are important in detecting the primary tumor site. Primary carcinoid tumors of the testis are particularly rare with a high malignant potential warranting long-term follow-up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/3614387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304607PMC
December 2018
2 Reads

Early development of a gonadal tumor in a patient with mixed gonadal dysgenesis.

Arch Endocrinol Metab 2018 ;62(6):644-647

Grupo Interdisciplinar de Estudos da Determinação e Diferenciação do Sexo (GIEDDS), Faculdade de Ciências Médicas, Universidade Estadual de Campinas (FCM-Unicamp), Campinas, SP, Brasil.

A gonadal tumor was diagnosed in the first months of life in a patient with genital ambiguity, a 45,X/46,XY karyotype, and mixed gonadal dysgenesis. Gonadal biopsies at the age of 3 months revealed dysgenetic testes and a gonadoblastoma on the right testis. Even though gonadal tumors are rare in childhood, this case indicates that prophylactic removal of dysgenetic gonads should be performed as early as possible, especially when the female sex is assigned to a patient with a Y-chromosome sequence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.20945/2359-3997000000091DOI Listing
February 2019
3 Reads

Cancer-testis antigens in ovarian cancer: implication for biomarkers and therapeutic targets.

J Ovarian Res 2019 Jan 4;12(1). Epub 2019 Jan 4.

The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, 210004, China.

Ovarian cancer remains the most fatal gynecologic malignancy worldwide due to delayed diagnosis as well as recurrence and drug resistance. Thus, the development of new tumor-related molecules with high sensitivity and specificity to replace or supplement existing tools is urgently needed. Cancer-testis antigens (CTAs) are exclusively expressed in normal testis tissues but abundantly found in several types of cancers, including ovarian cancer. Read More

View Article

Download full-text PDF

Source
https://ovarianresearch.biomedcentral.com/articles/10.1186/s
Publisher Site
http://dx.doi.org/10.1186/s13048-018-0475-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318940PMC
January 2019
18 Reads

Gossypol inhibits 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase: Its possible use for the treatment of prostate cancer.

Fitoterapia 2019 Mar 31;133:102-108. Epub 2018 Dec 31.

Central Laboratory, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, China. Electronic address:

Gossypol is a yellow polyphenol isolated from cotton seeds. It has the antitumor activity and it is being tested to treat prostate cancer. However, its underlying mechanisms are still not well understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2018.12.024DOI Listing
March 2019
2 Reads
2.216 Impact Factor

Long-Term Experience of Sperm Cryopreservation in Cancer Patients in a Single Fertility Center.

World J Mens Health 2019 May 26;37(2):219-225. Epub 2018 Dec 26.

Department of Urology, Fertility Center of CHA Gangnam Medical Center, CHA University College of Medicine, Seoul, Korea.

Purpose: Sperm cryopreservation before cancer treatment is the most effective method to preserve the fertility of male patients. We present our 21 years experience with sperm cryopreservation for cancer patients, including an examination of semen quality, the current status of cryopreserved sperm, and the rate of sperm use for assisted reproductive technology (ART).

Materials And Methods: A total of 721 cancer patients at Fertility Center of CHA Gangnam Medical Center successfully performed sperm cryopreservation for fertility preservation from January 1996 to December 2016. Read More

View Article

Download full-text PDF

Source
https://wjmh.org/DOIx.php?id=10.5534/wjmh.180061
Publisher Site
http://dx.doi.org/10.5534/wjmh.180061DOI Listing
May 2019
11 Reads

Cancer/testis Antigen MAGEA3 Interacts with STAT1 and Remodels the Tumor Microenvironment.

Int J Med Sci 2018 22;15(14):1702-1712. Epub 2018 Nov 22.

Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.

Cancer-testis antigen MAGEA3, being restrictedly expressed in testis and various kinds of tumors, has long been considered as an ideal target for immunotherapy. In this study, we report that MAGEA3 interacts with STAT1 and regulates the expression of tyrosine phosphorylated STAT1 (pY-STAT1) in tumor cells. We show that pY-STAT1 is significantly up-regulated when MAGEA3 is silenced by MAGEA3-specific siRNA. Read More

View Article

Download full-text PDF

Source
http://www.medsci.org/v15p1702.htm
Publisher Site
http://dx.doi.org/10.7150/ijms.27643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299422PMC
April 2019
17 Reads

Large-cell calcifying Sertoli cell tumour with macrocalcification in partially resected testis of young adult patient.

Malays J Pathol 2018 Dec;40(3):343-348

University of Niš Faculty of Medicine, Scientific Research Centre for Biomedicine, Serbia, Zoran Đinđic Boulevard 81, 18000 Niš, Serbia.

Introduction: There are less than 100 cases of Large-cell calcifying Sertoli cell tumour (LCCSCT) reported in English literature. Most of them are benign, bilateral and affect paediatric population. Malignant cases occur in older patients. Read More

View Article

Download full-text PDF

Source
December 2018
12 Reads

Resection of ruptured hepatic teratoma in an adult.

Int J Surg Case Rep 2018 22;53:414-419. Epub 2018 Nov 22.

Department of General Surgery, Royal Columbian Hospital, University of British Columbia, New Westminster, BC, Canada. Electronic address:

Introduction: Extragonadal locations of teratomas are uncommonly reported in the literature. Teratomas are neoplasms usually found in the gonadal organs: ovaries and testis. The majority of teratomas are found in the pediatric age group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijscr.2018.11.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259038PMC
November 2018
2 Reads

Datasets for the reporting of neoplasia of the testis: recommendations from the International Collaboration on Cancer Reporting.

Histopathology 2019 Jan;74(1):171-183

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

We here describe the development of an evidence-based cancer dataset by an International Collaboration on Cancer Reporting expert panel for the reporting of primary testicular neoplasia, and present the 'required' and 'recommended' elements to be included in the pathology report, as well as a commentary. This dataset encompasses the updated 2016 World Health Organisation classification of urological tumours, the results of an International Society of Urological Pathology consultation, and also staging with our preferred method: the American Joint Committee on Cancer version 8. Implementation of this dataset will facilitate consistent and accurate data collection between different cohorts, facilitate research, and hopefully result in improved patient management. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/his.13736
Publisher Site
http://dx.doi.org/10.1111/his.13736DOI Listing
January 2019
12 Reads

Primary signet-ring stromal tumour of the testis: case report with literature review.

APMIS 2019 Jan;127(1):45-49

Institute of Pathology, University of Göttingen, Göttingen, Germany.

Primary signet-ring stromal tumour of the testis (PSRSTT) is a very rare type of primary testicular tumour, which is not actually mentioned in the current WHO categorization of tumours of the male genital organs. In this case we report about histologically and immunohistochemically features of this rare tumour. In the present case, PSRTT was found in the orchiectomy preparation of a 69-year-old man with painless swelling of his left testicle. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.12907DOI Listing
January 2019
4 Reads

[Myeloid Sarcoma of the Testis].

Hinyokika Kiyo 2018 Nov;64(11):459-463

The Department of Urology, Yokohama City Minato Red Cross Hospital.

A 68-year-old man with swelling of his left testis was referred to our hospital. There was no history of hematologic disease. The diameter of the testicular mass was 40 mm. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14989/ActaUrolJap_64_11_459DOI Listing
November 2018
1 Read

Lymphoma transformation of tumor infiltrating lymphocytes observed in testicular patient‑derived xenograft models.

Oncol Rep 2018 Dec 5;40(6):3593-3602. Epub 2018 Oct 5.

Translational Research Unit, Faculty of Medicine, Comenius University and National Cancer Institute, 83310 Bratislava, Slovakia, Slovakia.

Testicular germ cell tumors (TGCTs) are highly sensitive to cisplatin‑based chemotherapy. Nevertheless, there are metastatic tumors that do not completely respond to front‑line chemotherapy. For these tumors, surgical resection of residual masses is necessary to achieve long‑term disease control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/or.2018.6769DOI Listing
December 2018

Histone methyltransferase SUV39H2 serves oncogenic roles in osteosarcoma.

Oncol Rep 2019 Jan 1;41(1):325-332. Epub 2018 Nov 1.

Department of Orthopaedics, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, P.R. China.

Suppressor of variegation 3‑9 homologue 2 (SUV39H2), a SET domain‑containing histone methyl-transferase, trimethylates histone H3 at lysine 9 and serves crucial roles in heterochromatin organization and genome stability. SUV39H2 is overexpressed in various types of human cancer, whereas it is almost undetectable in normal adult tissues, except testis. The aim of this study was to investigate a potential role of SUV39H2 in osteosarcoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/or.2018.6843DOI Listing
January 2019
3 Reads

Leydig cell tumor in an Amur tiger (Panthera tigris altaica).

J Vet Med Sci 2019 Feb 12;81(2):186-189. Epub 2018 Dec 12.

Department of Veterinary Pathology, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan.

A 14-year and 8-month-old intact male Amur tiger presented with an enlarged left testis, measuring 5.7 × 5.5 × 4. Read More

View Article

Download full-text PDF

Source
https://www.jstage.jst.go.jp/article/jvms/advpub/0/advpub_18
Publisher Site
http://dx.doi.org/10.1292/jvms.18-0573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395220PMC
February 2019
14 Reads

Molecular characterization of testicular germ cell tumors: chasing the underlying pathways.

Future Oncol 2019 Jan 7;15(3):227-229. Epub 2018 Dec 7.

Departments of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/fon-2018-0617DOI Listing
January 2019
15 Reads

[18F-FDG PET/CT features on paraganglioma of testis with multiple lymph node and lung metastasis: A case report and literature review].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Oct;43(10):1164-1168

PET/CT Center, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Objective: To determine the clinicopathological and imaging features in 18F-fluoro-2-deoxyglucose (18F-FDG) positron emission tomography and computed tomography (PET/CT) for paraganglioma of testis, and to increase the diagnostic accuracy.
 Methods: A case of paraganglioma of testis with multiple lymph node and lung metastasis were reported. PET/CT and pathological findings in the case were retrospectively analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11817/j.issn.1672-7347.2018.10.019DOI Listing
October 2018
2 Reads

Paratesticular rhabdomyosarcoma mimicking complicated epididymal cyst.

J Cancer Res Ther 2018 Dec;14(Supplement):S1241-S1243

Department of Urology, Faculty of Medicine, Kemerburgaz University, Medical Park Bursa Hospital, Bursa, Turkey.

Paratesticular rhabdomyosarcoma (RMS) is a rare nongerm cell intrascrotal malignant tumor in children and young adult/teens resulting from the mesenchymal tissues of the tunica vaginalis, epididymis, spermatic cord, and testis. RMS accounts for approximately 7% of all genitourinary tract RMSs and 12% of all pediatric scrotal neoplasms. Patients usually present with a painless unilateral scrotal mass. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/0973-1482.183553DOI Listing
December 2018
1 Read

Derivation of pluripotent stem cells from nascent undifferentiated teratoma.

Dev Biol 2019 02 5;446(1):43-55. Epub 2018 Dec 5.

Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai, Miyagi, Japan; Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi, Japan; The Japan Agency for Medical Research and Development-Core Research for Evolutional Science and Technology (AMED-CREST), Chuo-ku, Tokyo, Japan; Center for Regulatory Epigenome and Diseases, Tohoku University School of Medicine, Sendai, Miyagi, Japan. Electronic address:

Teratomas are tumors consisting of components of the three germ layers that differentiate from pluripotent stem cells derived from germ cells. In the normal mouse testis, teratomas rarely form, but a deficiency in Dead-end1 (Dnd1) in mice with a 129/Sv genetic background greatly enhances teratoma formation. Thus, DND1 is crucial for suppression of teratoma development from germ cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ydbio.2018.11.020DOI Listing
February 2019
4 Reads

Deep learning for detecting tumour-infiltrating lymphocytes in testicular germ cell tumours.

J Clin Pathol 2019 Feb 5;72(2):157-164. Epub 2018 Dec 5.

Nuffield Department of Surgical Sciences and NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.

Aims: To evaluate if a deep learning algorithm can be trained to identify tumour-infiltrating lymphocytes (TILs) in tissue samples of testicular germ cell tumours and to assess whether the TIL counts correlate with relapse status of the patient.

Methods: TILs were manually annotated in 259 tumour regions from 28 whole-slide images (WSIs) of H&E-stained tissue samples. A deep learning algorithm was trained on half of the regions and tested on the other half. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jclinpath-2018-205328DOI Listing
February 2019
3 Reads

Cytology of effusions in the coelom cavities.

Cesk Patol Fall 2018;63(4):175-189

oelom cavities (pleura, pericardium, peritoneum, tunica vaginalis testis) lined with mesothelial lining derived from the mesoderm, represent a frequent place of propagation of pathological processes both from the neighbourhood and primary. These are most often manifested by effusion, whose cytological examination contributes significantly to the diagnosis. Each larger amount of fluid in the coelom spaces is pathological. Read More

View Article

Download full-text PDF

Source
April 2019
14 Reads

CSE1L participates in regulating cell mitosis in human seminoma.

Cell Prolif 2019 Mar 28;52(2):e12549. Epub 2018 Nov 28.

Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objectives: CSE1L has been reported to be highly expressed in various tumours. Testicular germ cell tumours are common among young males, and seminoma is the major type. However, whether CSE1L has functions in the seminoma is unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cpr.12549DOI Listing
March 2019
1 Read

MR Imaging of the Testicular and Extratesticular Tumors: When Do We Need?

Magn Reson Imaging Clin N Am 2019 Feb 29;27(1):151-171. Epub 2018 Oct 29.

Section of Body Imaging, Yale School of Medicine, 20 York Street, PO Box 208042, New Haven, CT 06520-8042, USA.

Testicular ultrasound is typically the first-line imaging examination in evaluating scrotal pathology. However, MR imaging can often provide valuable additional information, especially when ultrasound and/or clinical examinations are inconclusive. This is particularly evident when encountering testicular or paratesticular lesions, where accurate localization and characterization are paramount for management and prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mric.2018.08.006DOI Listing
February 2019
17 Reads

Ameliorative effects of rutin against cisplatin-induced reproductive toxicity in male rats.

BMC Urol 2018 Nov 21;18(1):107. Epub 2018 Nov 21.

Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.

Background: Cisplatin (CP) or cis-diammine dichloroplatinum (II) is a platinum based standard antineoplastic drug which is used against variety of solid tumors and neoplasms. The present study aimed to evaluate the shielding effects of rutin against CP induced testicular toxicity in rats.

Methods: 28 male rats were divided into four groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12894-018-0421-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249881PMC
November 2018
14 Reads

Case 36-2018: A 29-Year-Old Man with an Incidentally Discovered Renal Mass.

N Engl J Med 2018 11;379(21):2064-2072

From the Departments of Urology (D.M.D.), Radiology (J.F.S.), Medicine (O.I., P.J.S.), and Pathology (C.-L.W.), Massachusetts General Hospital, and the Departments of Surgery (D.M.D.), Radiology (J.F.S.), Medicine (O.I., P.J.S.), and Pathology (C.-L.W.), Harvard Medical School - both in Boston.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMcpc1802832DOI Listing
November 2018
19 Reads

NUT carcinoma of the nasal cavity that responded to a chemotherapy regimen for Ewing's sarcoma family of tumors: a case report.

BMC Cancer 2018 Nov 19;18(1):1134. Epub 2018 Nov 19.

Department of Hematology/Oncology, Japan Community Healthcare Organization Kyushu Hospital, Fukuoka, Japan.

Background: Nuclear protein in testis (NUT) carcinoma (NC) is a rare epithelial malignancy characterized by rearrangement of the NUT gene on chromosome 15. If NC is not suspected, it is often diagnosed as other malignancies. We present the case of NC of the nasal cavity that responded to a chemotherapy regimen for Ewing's sarcoma family of tumors (ESFT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12885-018-5087-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245604PMC
November 2018
19 Reads

The role of Cancer/Testis Antigens in Multiple Myeloma pathogenesis and their application in disease monitoring and therapy.

Crit Rev Oncol Hematol 2018 Dec 14;132:17-26. Epub 2018 Sep 14.

Department of Medicine, University of Cape Town, South Africa.

A unique group of genes, encoding tumour associated antigens, known as the Cancer/Testis Antigens (CTAs), have been explored as novel markers of disease progression and as targets of immunotherapy in several cancers, including the haematological malignancy Multiple Myeloma (MM). This review aims to update the knowledge of CTA involvement in MM pathogenesis and how their potential as biomarkers for disease monitoring and targets of immunotherapy has been explored in the MM disease arena. Despite the initial promise of these antigens, their use as immunotherapy targets has not been successful, yet with a greater understanding of their role in disease pathogenesis they may still have a significant role to play as biomarkers of disease and therapeutic targets. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10408428183026
Publisher Site
http://dx.doi.org/10.1016/j.critrevonc.2018.09.010DOI Listing
December 2018
12 Reads

Updates in Staging and Reporting of Testicular Cancer.

Surg Pathol Clin 2018 Dec;11(4):813-824

Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Room 4010, Indianapolis, IN 46202, USA. Electronic address:

The American Joint Committee for Cancer eighth edition staging manual incorporated several critical changes regarding staging of testis germ cell tumors, and these changes are summarized and discussed in this article. Further challenges, however, remain, and these are also highlighted. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18759181183004
Publisher Site
http://dx.doi.org/10.1016/j.path.2018.07.005DOI Listing
December 2018
16 Reads

A Contemporary Review of Common Adult Non-germ Cell Tumors of the Testis and Paratestis.

Surg Pathol Clin 2018 Dec 17;11(4):739-758. Epub 2018 Oct 17.

Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, L235, Stanford, CA 94305, USA. Electronic address:

This article provides a comprehensive review of non-germ cell tumors of the testis and paratestis in adults, incorporating the latest 2016 World Health Organization updates. Clinical features, gross pathologic findings, key morphologic details, immunohistochemical profiles, and differential diagnoses are covered, with an emphasis on how to resolve commonly encountered, and sometimes difficult, differential diagnoses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.path.2018.07.002DOI Listing
December 2018
2 Reads