16,902 results match your criteria Testicle Malignant Tumors


Prevalence and ultrasound patterns of testicular adrenal rest tumors in adults with congenital adrenal hyperplasia.

Transl Androl Urol 2021 Feb;10(2):562-573

Department of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Background: Testicular adrenal rest tumors (TARTs) are benign neoplasms affecting patients with congenital adrenal hyperplasia (CAH). The prevalence of TART in adult patients with CAH is not well known. Ultrasonography (US) is the main tool for diagnosing TART and the role of contrast-enhanced US (CEUS) is never investigated. Read More

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February 2021

28-Year-Old Man With an Enlarged Left Testicle.

Mayo Clin Proc 2021 04 10;96(4):1047-1051. Epub 2021 Mar 10.

Advisor to residents and Consultant in General Internal Medicine, Mayo Clinic, Rochester, MN. Electronic address:

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Emerging oncogene ATAD2: Signaling cascades and therapeutic initiatives.

Life Sci 2021 Jul 9;276:119322. Epub 2021 Mar 9.

Biochemistry and Cell Biology Laboratory, School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Odisha 752050, India. Electronic address:

ATAD2 is a promising oncoprotein with tumor-promoting functions in many cancers. It is a valid cancer drug-target and a potential cancer-biomarker for multiple malignancies. As a cancer/testis antigen (CTA), ATAD2 could also be a probable candidate for immunotherapy. Read More

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Painful testicular swelling: an unusual localization of sarcoidosis.

Pan Afr Med J 2020 28;36:222. Epub 2020 Jul 28.

Pneumo-Phtisiology Department, Faculty of Medicine and Pharmacy of Rabat, Moulay Youssef Hospital, Rabat, Morocco.

Sarcoidosis is a systemic inflammatory disease characterized by non-caseating epitheloid granulomas; whereas it usually involves the lungs and lymph nodes. Testicular sarcoidosis is extremely rare, having been reported to occur in 0.2% of all sarcoidosis patients. Read More

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Poroid adnexal skin tumors with YAP1 fusions exhibit similar histopathologic features: A series of six YAP1-rearranged adnexal skin tumors.

J Cutan Pathol 2021 Mar 11. Epub 2021 Mar 11.

Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Background: Adnexal skin tumors are diagnostically challenging with few known molecular signatures. Recently, however, YAP1-MAML2 and YAP1-NUTM1 fusions were identified in poroid adnexal skin tumors.

Methods: Herein, we subjected eight poroid adnexal skin tumors (three poromas and five porocarcinomas) to fusion gene analysis by whole transcriptome sequencing and next-generation DNA sequencing analysis. Read More

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Immune Profile Analysis in Peripheral Blood and Tumor in Patients with Malignant Melanoma.

Int J Mol Sci 2021 Feb 16;22(4). Epub 2021 Feb 16.

Department of Dermatology, University of Occupational and Environmental Health 1-1, Iseigaoka, Yahatanishi-Ku, Kitakyushu 807-8555, Japan.

Melanoma is a severe and life-threatening malignancy derived from melanocytes. The traditional treatment for melanoma could not sustain satisfactory outcomes long term; however, the recent immune checkpoint treatment has made a breakthrough in these problems. Nivolumab is a representative immune checkpoint treatment, and this PD-1-targeted therapy has evolutionally developed and improved the clinical outcome in a recent decade. Read More

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February 2021

Prostate cancer metastasis to the testis: an unexpected presentation of a solitary recurrence.

BMJ Case Rep 2021 Mar 2;14(3). Epub 2021 Mar 2.

Urology Department, Altnagelvin Hospital, Western Health and Social Care Trust, Derry, UK.

A 74-year-old man with a history of prostate cancer was referred to the urology team with a new left sided testicular lump. He had a background of prostate cancer 4 years previous which had been treated with external beam radiotherapy and androgen deprivation therapy, both of which had been completed. Concurrently, he also had evidence of biochemical recurrence of prostate cancer with a rising prostate-specific antigen (PSA). Read More

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[Leydig Cell Tumor in a Patient with Contralateral Cryptorchidism: A Rare Association].

Acta Med Port 2021 Feb 22;34(2):137-139. Epub 2020 Sep 22.

Unidade de Saúde Familiar do Dafundo. Lisboa. Portugal.

Gynecomastia is a frequent sign that may be physiological or caused by various benign or malignant diseases. In rare cases, it may be caused by testicular tumors. We describe a case of progressive gynecomastia at age 20 due to a Leydig cell tumor of the right testicle in a patient with a previous history of left-sided cryptorchidism. Read More

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February 2021

TSP50 promotes hepatocyte proliferation and tumour formation by activating glucose-6-phosphate dehydrogenase (G6PD).

Cell Prolif 2021 Apr 25;54(4):e13015. Epub 2021 Feb 25.

National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, China.

Background & Aims: Hepatocellular carcinoma (HCC) is a common malignant tumour with high morbidity and mortality. Metabolic regulation by oncogenes is necessary for tumour growth. Testes-specific protease 50 (TSP50) has been found to promote cell proliferation in multiple tumour types. Read More

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Evolution, structure and emerging roles of C1ORF112 in DNA replication, DNA damage responses, and cancer.

Cell Mol Life Sci 2021 May 24;78(9):4365-4376. Epub 2021 Feb 24.

Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, L7 8TX, UK.

The C1ORF112 gene initially drew attention when it was found to be strongly co-expressed with several genes previously associated with cancer and implicated in DNA repair and cell cycle regulation, such as RAD51 and the BRCA genes. The molecular functions of C1ORF112 remain poorly understood, yet several studies have uncovered clues as to its potential functions. Here, we review the current knowledge on C1ORF112 biology, its evolutionary history, possible functions, and its potential relevance to cancer. Read More

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Reliability of Serum Tumor Marker Measurement to Diagnose Recurrence in Patients with Clinical Stage I Nonseminomatous Germ Cell Tumors Undergoing Active Surveillance: A Systematic Review.

J Urol 2021 Jun 22;205(6):1569-1576. Epub 2021 Feb 22.

Department of Urology, IRCCS San Raffaele Hospital and Scientific Institute, Milan, Italy.

Purpose: Men with nonseminomatous germ cell tumors of the testicle without evidence of residual disease after radical orchiectomy (clinical stage I) are increasingly managed with active surveillance. The guideline-recommended cornerstones of surveillance are conventional serum tumor markers and computerized tomography. The reliability of serum tumor markers as a tool to diagnose early recurrence of clinical stage I nonseminomatous germ cell tumors is unclear. Read More

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Testis-Specific Thioredoxins TXNDC2, TXNDC3, and TXNDC6 Are Expressed in Both Testicular and Systemic DLBCL and Correlate with Clinical Disease Presentation.

Oxid Med Cell Longev 2021 1;2021:8026941. Epub 2021 Feb 1.

Cancer and Translational Medicine Research Unit, University of Oulu, Finland.

DLBCL is the most common type of non-Hodgkin lymphoma with a substantial group of patients suffering a poor prognosis. Therefore more specific markers are required for better understanding of disease biology and treatment. This study demonstrates that testis-specific antioxidant enzymes TXNDC2, TXNDC3, and TXNDC6 alongside oxidative stress marker 8-OHdG are expressed in both testicular and systemic DLBCL, and their presence or absence has correlations with clinical risk factors such as the number of extranodal effusion, the appearance of B-symptoms, and treatment response. Read More

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[A Case of Diffuse Large B-Cell Lymphoma of the Testis, Which Also Developed in the Rectum after Resection of a Large B-Cell Lymphoma].

Gan To Kagaku Ryoho 2021 Feb;48(2):303-305

Dept. of Surgery, Todachuo General Hospital.

A man aged 65 years had undergone high orchidectomy of the right testis for diffuse large B-cell lymphoma(DLBCL) occurring primarily in the testis 11 months before. Although he was referred to another hospital for postoperative chemotherapy, he refused the treatment by self-judgement. For 1 month, he had been experiencing melena and anal pain, so he visited our department in June. Read More

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February 2021

Nivolumab-caused hyperprogression of diffuse large B-cell lymphoma of the testis and spontaneous remission of type 2 diabetes mellitus in an elderly patient: a case report.

Anticancer Drugs 2021 06;32(5):575-579

Department of Medical Oncology.

Nivolumab has been used in a variety of advanced malignant tumors. Cases of autoimmune diabetes associated with Nivolumab therapy have been reported gradually in recent years. This article reported a case of primary testicular lymphoma in an elderly patient with type 2 diabetes mellitus (T2DM). Read More

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Radiotherapy after testis-sparing surgery for seminoma in monorchid patients: safety and efficacy.

Tumori 2021 Feb 15:300891621992428. Epub 2021 Feb 15.

Urology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Purpose: To evaluate local control and longitudinal endocrine data in monorchid patients treated with testicular-sparing surgery and adjuvant radiotherapy (RT) for seminomatous germ-cell tumors.

Methods: We searched our database established in 2009 for patients with seminoma who received testis irradiation following partial orchiectomy up to 2018. Eleven patients were identified. Read More

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February 2021

Expression profile analysis of a new testis-specifically expressed gene C17ORF64 and its association with cell apoptosis in MCF-7 cells.

Mol Biol Rep 2021 Feb 10;48(2):1521-1529. Epub 2021 Feb 10.

Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, 414000, Hunan, China.

With the increasing incidence of male infertility, identification and investigation the functions of new genes related to spermatogenesis are effective avenues to elucidate the decline of testicular function. In this study, a new gene, C17ORF64 (chromosome 17 open reading frame 64), was identified from mouse testes and its potential function was studied.RT-PCR and qRT-PCR assay showed that C17ORF64 mRNA was expressed exclusively in mouse testes and up-regulated from the 3-week old to 6-month old testes during postpartum development, which is consistent with C17ORF64 protein expression profile by western blotting analysis. Read More

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February 2021

Rare presentation of isolated bilateral testicular myeloid sarcoma: A case report.

Urol Case Rep 2021 May 28;36:101585. Epub 2021 Jan 28.

Department of Urology, Austin Health, Heidelberg, Victoria, Australia.

Myeloid sarcoma (MS) of the testis is a rare soft tissue tumour which can herald the development of acute myeloid leukaemia (AML). The diagnosis of MS requires a high degree of suspicion as appropriate immunohistochemical staining must be performed to yield an early diagnosis. Whilst there is no consensus on treatment on MS involving the testis, most patients undergo orchidectomy and systemic chemotherapy, with or without radiation therapy. Read More

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Metastatic neuroendocrine tumour presenting as a testicular mass.

BMJ Case Rep 2021 Feb 4;14(2). Epub 2021 Feb 4.

Urology, Austin Health, Heidelberg, Victoria, Australia.

In this manuscript, we describe a rare case of neuroendocrine tumour metastatic to the testicle, presenting with testicular mass as an isolated symptom. We describe the investigations and management leading us to this uncommon histological diagnosis and explore its significance and impact on further management. Read More

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February 2021

Late testicular relapse two decades after primary extragonadal germ cell tumor with uncommon metastases: a case report.

J Med Case Rep 2021 Feb 5;15(1):59. Epub 2021 Feb 5.

The Department of Urology, Japan Community Health care Organization Kani Tono Hospital, 1221-5 Dota, Kani-shi, Gifu, 509-0206, Japan.

Background: Extragonadal germ cell tumor (EGCT) is a relatively rare condition, reportedly representing 3-7% of all germ cell tumors. We report a patient who had metachronous testicular tumor with uncommon metastases 20 years after primary retroperitoneal EGCT treatment, along with a corresponding literature review.

Case Presentation: A 49-year-old Japanese man visited our department in November 2017 with chief complaints of indolent right scrotum enlargement and a right inguinal mass. Read More

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February 2021

Primary intratesticular rhabdomyosarcoma in children: a case report and review of the literature.

J Med Case Rep 2021 Jan 31;15(1):37. Epub 2021 Jan 31.

Department of pathology, Kilimanjaro Christian Medical Centre (KCMC), Moshi, Tanzania.

Background: The importance of this paper is to help to emphasize the importance of chemotherapy for children with pure intratesticular rhabdomyosarcoma after radical inguinal orchiectomy is done as first treatment of rhabdomyosarcoma. The information provided in this paper about the follow-up outcomes of the patient described in this paper, it highlights that, recurrence and even metastasis of intratesticular rhabdomyosarcoma in children are more likely to occur if surgery it not combined with chemotherapy.

Case Presentation: Herein, we present a 6-year old African male child with a 3 months history of a painless right intratesticular tumour. Read More

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January 2021

Extranodal blastoid/pleomorphic variant of mantle cell lymphoma involving the testis and skin.

BMJ Case Rep 2021 Jan 28;14(1). Epub 2021 Jan 28.

Department of Hematology and Oncology, Beaumont Health, Royal Oak, Michigan, USA.

We report a case of extranodal mantle cell lymphoma of the testis in a 72-year-old Caucasian man who presented to his physician's office with rapidly enlarging left testicular mass and skin lesions which were subsequently biopsy-proven to be mantle cell lymphoma. We discuss the clinicopathological features and current management in relapsed and refractory settings of this rare presentation of mantle cell lymphoma. Read More

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January 2021

Stage I testicular seminoma risk-adapted therapeutic management.

Neoplasma 2021 May 28;68(3):613-620. Epub 2021 Jan 28.

1st Department of Oncology, Comenius University, Faculty of Medicine and St. Elisabeth Cancer Institute, Bratislava, Slovakia.

Following orchiectomy, patients with clinical stage I (CSI) testicular seminoma may be managed by active surveillance (S) or adjuvant treatment (radiotherapy or chemotherapy). In view of the published data on long-term toxicity, especially second malignant neoplasms (SMNs), adjuvant radiotherapy (ART) is currently no longer recommended as an adjuvant therapy option for these patients. The purpose of our recent study was to compare the impact of two selected treatment approaches - S versus adjuvant chemotherapy (ACT) on the survival of patients with CSI testicular seminoma. Read More

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Beyond germ cell tumors, unusual testicular and extra-testicular masses and mass-like lesions: MRI and US pictorial review.

Clin Imaging 2021 Jun 14;74:106-122. Epub 2021 Jan 14.

Department of Medical Imaging, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Testicular ultrasound (US) studies are nowadays widely performed as being readily available, cost effective with no side effects. Testicular ultrasounds are ordered to help in the diagnosis of various conditions, but more specifically, in cryptorchidism. Other reasons for conducting testicular ultrasonography include testicular pain to confirm presence of epididymitis or orchitis. Read More

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Pathologic concordance of resected metastatic nonseminomatous germ cell tumors in the chest.

J Thorac Cardiovasc Surg 2021 Mar 30;161(3):856-868.e1. Epub 2020 Nov 30.

Division of Thoracic Surgery, Princess Margaret Cancer Center, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Objective: Men with metastatic nonseminomatous germ cell tumors (NSGCTs) often present with residual chest tumors after chemotherapy. We examined the pathologic concordance of intrathoracic disease and outcomes based on the worst pathology of disease resected at first thoracic surgery.

Methods: A retrospective analysis was performed of consecutive patients undergoing thoracic resection for metastatic NSGCT in our institution between 2005 and 2018. Read More

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[A Case Report of Primary Pulmonary NUT Carcinoma and Literature Review].

Zhongguo Fei Ai Za Zhi 2021 Jan;24(1):63-68

Department of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu 610041, China.

NUT carcinoma is a rare, high lethal cancer which feature as the rearrangement of the nuclear protein in testis (NUT) gene on chromosome 15q14, and its pathogenesis and treatment is not yet clear, the prognosis is poor. Due to NUT carcinoma often occurred on the middle position of the body, such as eyes, nose and palate, mediastinum, so it is also called NUT midline carcinoma (NMC). In this case, we report a 70 years old man who was diagnosed as primary pulmonary NUT carcinoma in the Department of Thoracic Oncology, West China Hospital of Sichuan University. Read More

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January 2021

Radical inguinal orchidectomy: the gold standard for initial management of testicular cancer.

Transl Androl Urol 2020 Dec;9(6):3094-3102

Department of Urology, St. Vincent's Hospital Melbourne, Melbourne, Australia.

Radical inguinal orchidectomy with division of the spermatic cord at the internal inguinal ring is the gold standard for diagnosis and local treatment of testicular malignancies. The technique is well established and described in detail in this paper, collating methods from various surgical textbooks and articles. We also discuss pre-operative considerations including fertility counselling and potential testicular prosthesis at time of orchidectomy, and the importance of contemplating differential diagnoses such as para-testicular sarcoma and primary testicular lymphoma (PTL) prior to performing radical orchidectomy (RO). Read More

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December 2020

Mixed granulosa-Sertoli sex cord-stromal tumor of the testis: clinical, ultrasonic and histopathological features: a case report.

Transl Androl Urol 2020 Dec;9(6):2836-2841

Department of Pathology, The First Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.

Testicular sex cord-stromal tumors are less common in men, while mixed sex cord-stromal tumors (MSCSTs) are rarer. Recently, we found a MSCST in an adult male testis [adult granulosa cell tumor (AGCT) with Sertoli cell tumor]. He was admitted to the hospital based on "left testicular bloating and dull pain for 20 years and aggravating for 10 days". Read More

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December 2020

Blood testis barrier revisited-Analysis of post-chemotherapy germ cell tumor orchidectomy and retroperitoneal lymph node dissection specimens.

J Surg Oncol 2021 Mar 11;123(4):1157-1163. Epub 2021 Jan 11.

Homi Bhabha National Institute, Mumbai, India.

Objective: To assess the response of chemotherapy on the primary tumor, compare it with the response in retroperitoneal disease, and study factors associated with pathological complete response.

Methods: We conducted a retrospective audit of all high inguinal orchidectomies (HIOs) performed after chemotherapy between 2012 and 2019 at a tertiary cancer center in India. Patient characteristics and histopathological response were extracted from electronic medical records, and predictors of testicular disease response were assessed. Read More

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Combined RNA/tissue profiling identifies novel Cancer/Testis genes.

Mol Oncol 2021 Jan 11. Epub 2021 Jan 11.

Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000, Rennes, France.

Cancer/Testis (CT) genes are induced in germ cells, repressed in somatic cells and de-repressed in somatic tumors, where these genes can contribute to cancer progression. CT gene identification requires data obtained using standardized protocols and technologies. This is a challenge because data for germ cells, gonads, normal somatic tissues and a wide range of cancer samples stem from multiple sources and were generated over substantial periods of time. Read More

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January 2021