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J Cardiothorac Surg 2019 Jun 20;14(1):113. Epub 2019 Jun 20.

Department of Thoracic surgery, Peking Union Medical College Hospital, Peking Union Medical College, Dongcheng District, Beijing, 100730, China.

Background: Extralobar sequestration is a rare congenital malformation of lung tissue, which can be combined with other foregut and cardiac abnormalities. Our case is the first to report extralobar sequestration, absence of pericardium and atrial septal defect in the same patient.

Case Presentation: A 22-year-old female with atrial septal defect came for her recent atypical symptom of intermittent palpitation and shortness of breath. Read More

Tumori 2018 Dec 6;104(6):NP57-NP60. Epub 2018 Apr 6.

Institute of Radiology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.

Thymolipoma is a rare tumor of the thymus. Classic radiologic findings of thymolipoma include fatty masses of the anterior mediastinum in conjunction with the thymus. Differential diagnosis with other more aggressive entities like liposarcoma and teratoma can be challenging. Read More

J Coll Physicians Surg Pak 2018 03;28(3):243-244

Department of Pathology & Laboratory Medicine, The Aga Khan University and Hospital, Karachi.

Teratomas can be found in different organs of the body and may involve gonads, saccrococcygeal region, mediastinum and other sites. Intrathoracic teratomas always occur in mediastinum and less often arise within the lung. As teratomas mostly involve sex organs (gonads), they rarely occur as extra-gonadal tumors accounting for only 3% of all the cases and very small percentage of such tumors occur in mediastinum. Read More

Diagn Pathol 2016 Aug 15;11(1):76. Epub 2016 Aug 15.

Universidade do Oeste de Santa Catarina, Joaçaba, Brazil.

Background: Germ cell tumors are tumors composed of tissues derived from more than one of the three germinal layers. They are more common in the testes and ovaries, but can present in many different regions in the midline, including the sacral region, retroperitoneum, mediastinum, and brain. Testicular germ cell tumors generally metastasize to the retroperitoneum, lungs, and brain; metastases to soft tissue are very rare. Read More

Pathologe 2016 Sep;37(5):441-8

Institut für Pathologie, Universitätsmedizin Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Deutschland.

The mediastinum is among the most frequent anatomic region in which germ cell tumors (GCT) arise, second only to the gonads. Mediastinal GCT (mGCT) account for 16 % of all mediastinal neoplasms. Although the morphology and (according to all available data) the molecular genetics of mediastinal and gonadal GCT are identical, a number of unique aspects exist. Read More

J Clin Endocrinol Metab 2016 05 10;101(5):1980-8. Epub 2016 Mar 10.

Department of Pediatric Endocrinology, Marmara University Medical School (Z.A., S.T., T.G., A.B.), Istanbul, Turkey; Department of Pediatric Endocrinology, Gulhane Military Medical School (E.Y., E.S.), Ankara Turkey; Department of Pediatric Endocrinology, Dr. Sami Ulus Research Hospital (S.S.E., Z.A., S.C.), Ankara, Turkey; Department of Pediatric Endocrinology, Erciyes University Medical School (L.A., S.K.), Kayseri, Turkey; Department of Pediatric Endocrinology, Uludag University Medical School (E.E., H.S.), Bursa, Turkey; Department of Pediatric Endocrinology, Gazi University Medical School (E.D., A.B.), Ankara, Turkey; Department of Pediatric Endocrinology, Istanbul University Medical School (Z.Y.A.), Istanbul, Turkey; Department of Pediatric Endocrinology, Inonu University Medical School (A.A.), Malatya, Turkey; Department of Pediatric Endocrinology, Ankara University Medical School (Z.S.), Ankara, Turkey; Department of Pediatric Endocrinology, Ege University Medical School (S.O.), Izmir, Turkey; Department of Pediatric Endocrinology, Ondokuz Mayıs University Medical School (C.K.), Samsun, Turkey; Department of Pediatric Endocrinology, Diskapi Research Hospital (M.T.), Ankara, Turkey; Department of Pediatric Endocrinology, Trakya University Medical School (F.T.), Edirne, Turkey; Department of Pediatric Endocrinology, Kocaeli University Medical School (G.S.K.), Kocaeli, Turkey; Department of Pediatric Endocrinology, Karadeniz Technical University Medical School (G.K.), Trabzon, Turkey.

Aim: The causes of gonadotropin-independent precocious puberty are diverse, and often have overlapping clinical and biochemical features. With the exception of congenital adrenal hyperplasia (CAH), disorders that cause gonadotropin-independent precocious puberty (GIPP) are uncommon. The literature is devoid of any large-scale studies on the etiologic distribution of GIPP. Read More

Int J Surg Pathol 2015 Dec 24;23(8):682-4. Epub 2015 Jun 24.

University Hospital of Saint Étienne, Saint Étienne, France

We report the case of a 76-year-old patient presenting with an anterior mediastinal heterogeneous mass. Surgical biopsy revealed a solid and cystic lesion filled with hair. Pathological examination showed an atypical papillary epithelial lining without other germ cell tumor or immature teratoma associated. Read More

Indian J Pathol Microbiol 2013 Apr-Jun;56(2):158-60

Texas Tech University Health Sciences Center - School of Medicine, Lubbock, USA.

The histological predominance of one component in a germ cell tumor can lead to a mistaken diagnosis. Here, we describe a mediastinal teratoma with predominant vascular proliferation (>90%) which on fine needle biopsy was diagnosed as a pulmonary hemangioma. Later, resection specimen revealed other components constituting ~4%, changing the diagnosis while illustrating theimportance of careful evaluation. Read More

Rev Mal Respir 2012 Nov 28;29(9):1111-5. Epub 2012 Sep 28.

Service de chirurgie thoracique, faculté de médecine et de pharmacie de Rabat, université Mohamed V Souissi, hôpital militaire d'instruction Mohamed V, Hay Riad, Rabat, Morocco.

Introduction: Benign cystic mediastinal mass form a group of heterogeneous and uncommon lesions. Surgical resection is the gold standard in these conditions. We reported our institutional experience in management of these benign tumours. Read More

Singapore Med J 2012 Nov;53(11):e237-9

Department of Pathology, Medical College, Kolkata, India.

Intrathoracic teratomas are usually seen in the mediastinum; they rarely occur in the lung as intrapulmonary teratomas. The criteria for pulmonary origin are the exclusion of a gonadal site or other extragonadal primary sites and the exclusive origin of the tumour from the lung. Lung teratomas, for reasons unknown, commonly involve the upper lobe. Read More

Pediatr Dev Pathol 2012 Nov-Dec;15(6):511-3. Epub 2012 Aug 28.

Section of Perinatal Pathology, Department of Pathology, Karolinska University Hospital and Karolinska Institutet, Huddinge, Stockholm, Sweden.

We report a rare case of a primitive embryonal tumor discovered in the upper anterior mediastinum during routine autopsy of a macerated fetus at the 18th week of gestation. Our diagnosis was based on autopsy findings and histologic examination, which showed neuroepithelial differentiation of the tumor with frequent ependymal-type rosette formation; no structures of other germ cell layer origin were revealed. Additional positive immunohistochemical staining for CD56, CD57, and neurofilament protein confirmed the neural origin of the tumor, whereas the genetic analysis showed no MYCN gene amplification and no 11q23 deletion or rearrangement of EWS locus (22q12). Read More

Pediatr Hematol Oncol 2012 Oct 9;29(7):633-42. Epub 2012 Aug 9.

Department of Pediatric Oncology, Institute of Oncology, Hacettepe University, Ankara, Turkey.

Background: Mediastinal germ cell tumors (GCTs) are rare and usually located in anterior mediastinum. We aimed to review clinical and pathological characteristics of these tumors.

Procedure: Between 1973 and 2011, 24 children with mediastinal GCTs were diagnosed. Read More

Ann Thorac Cardiovasc Surg 2011 27;17(6):588-90. Epub 2011 Jul 27.

Department of Thoracic Surgery, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama, Japan.

We present a 12-year-old girl with a teratoma with malignant transformation (TMT) of the mediastinum. Computed tomography showed a cystic mass (5.0 cm × 4. Read More

Chirurgia (Bucur) 2011 Mar-Apr;106(2):199-203

Clinica de Chirurgie Toracica, Institutul Oncologic Prof. Dr. Alexandru Trestioreanu, U.M.E Carol Davila Bucureşti, România.

The posterior mediastinum is the potential space along each side of the vertebral column and adjacent proximal portions of the ribs--the paravertebral sulci. From the posterior mediastinal tumors, the most commonly encountered are the neurogenic tumors (75%), the remaining 25% are represented by a heterogenous group of rare tumors including teratoma, lymphoma, sarcoma and other lesions arising outside the mediastinum and projecting into the posterior compartment. Surgical excision, by thoracotomy or miniinvasive techniques, is the first line of treatment in the posterior mediastinal tumors. Read More

Pediatr Neurosurg 2010 9;46(5):368-72. Epub 2011 Mar 9.

Department of Neurosurgery and Gamma Knife Centre, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Association of split cord malformation with teratoma is an extremely rare condition. It is very unusual to find split cord malformation with teratomas extending into the posterior mediastinum and still rarer to find bony spur arising dorsally and ventrally at the same level.

Case Report: The authors describe the case of a 2-year-old child who presented with dorsal kyphosis and a dermal sinus. Read More

Int J Surg Pathol 2011 Jun 6;19(3):321-7. Epub 2010 Dec 6.

Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

Teratoma with a malignant somatic component (MSC) is a rare phenomenon recognized when a somatic type malignancy occurs in the context of a germ cell tumor (GCT). The authors present their 29-year experience with 40 patients treated from 1981 to 2009 in their institution. The average age was 31 years. Read More

Rev Port Cir Cardiotorac Vasc 2009 Jul-Sep;16(3):143-7

Unidade Local de Saúde do Baixo Alentejo, Serviço de Cirurgia Geral do Hospital de Santo António dos Capuchos, Centro Hospital Lisboa Central.

Mediastinal germ cell tumours (M-GCT) are rare forms of neoplasms compared with other tumours of the same location. They are classified in seminomas, malignant non-seminomatous GCT and teratomas. The malignant transformation of the somatic component of the teratoma, with sarcomatous or carcinomatous degeneration, is even more uncommon. Read More

J Urol 2009 Jun 16;181(6):2526-32. Epub 2009 Apr 16.

Department of Urology and Oncology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Purpose: We determined outcomes in patients with testicular cancer with large volume (greater than 10 cm) retroperitoneal teratoma treated with post-chemotherapy retroperitoneal lymph node dissection.

Materials And Methods: A retrospective review of our testicular cancer database was performed from 1995 to 2005 to identify patients undergoing post-chemotherapy retroperitoneal lymph node dissection for residual masses larger than 10 cm with final pathological examination revealing teratoma. A total of 99 patients met the study inclusion criteria. Read More

Eur J Radiol 2009 Feb 3;69(2):230-5. Epub 2008 Dec 3.

Department of Radiology, Institut Gustave-Roussy, Villejuif, France.

Purpose: To describe the imaging findings of germ cell tumours (GCT) containing non-germ cell malignant components (also designated teratoma with malignant transformation or TMT).

Patients And Methods: The records of 14 male patients with GCT and a non-germ cell histological component TMT were retrospectively reviewed. All patients had computed tomography (CT) and/or magnetic resonance (MR) studies before and after initial surgery and chemotherapy, as well as during follow-up. Read More

Rev Mal Respir 2008 May;25(5):531-8

Service d'Anatomie et de cytologie pathologiques, Hôpital Abderrahman-Mami, Ariana, Tunis, Tunisie.

Introduction: Mature teratomas of the mediastinum are rare. However, they represent the most common mediastinal germ cell tumours. The aim of this study is to describe their clinical and pathological characteristics. Read More

Invest Clin 2007 Dec;48(4):509-14

Unidad de Anatomía Patológica, Instituto Autónomo Hospital Universidad de los Andes, Mérida, Venezuela.

Extragonadal teratomas are more frequent in the mediastinum and sacrococcygeal region. In this work, two cases of mature mediastinal teratoma, that simulated infection processes are reported. These cases appeared during the last semester of the year 2000 and represent the casuistry of the University Hospital of The Andes (IAHULA) between 1996 and 2005. Read More

Zhonghua Bing Li Xue Za Zhi 2007 Oct;36(10):666-71

Department of Pathology, the Children's Hospital of Jiangxi Province, Nanchang 330006, China.

Objective: To study the clinicopathologic features and biologic behavior of pediatric immature teratoma.

Methods: The clinical data, pathologic features, immunohistochemical findings (for cyclin D1, P27 and Ki-67) and follow-up information of 39 cases of pediatric immature teratoma were analyzed.

Results: Amongst the 39 cases studied, 12 arose in the sacrococcygeal region, 12 in testis, 5 in retroperitoneum, 4 in ovary, 4 in abdomen and 2 in mediastinum. Read More

Hum Pathol 2008 Feb 28;39(2):275-81. Epub 2007 Nov 28.

Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32608, USA.

Organic cation transporter 3/4 (OCT3/4) is a transcription factor of embryonic stem cells; c-kit (CD117) is a tyrosine kinase receptor implicated in seminoma carcinogenesis. Their reactivity is well characterized in testicular, but not extragonadal and metastatic, germ cell tumors. A total of 93 germ cell tumors (41 seminoma, 22 embryonal carcinoma, 18 teratoma, and 12 yolk sac tumor) were obtained from the central nervous system (30), mediastinum (23), retroperitoneum/abdomen (31), and other locations (9). Read More

Am J Surg Pathol 2007 Sep;31(9):1356-62

Department of Pathology, Instituto Nacional de Cancerología, Mexico.

The clinicopathologic features of 46 patients with germ cell tumors with sarcomatous components (GCTSC) involving either the primary site or their metastases were studied. There were 43 men and 3 women aged 17 to 74 years. Twenty-three tumors arose in the mediastinum, 2 in the retroperitoneum, and 21 in the gonads. Read More

Ann Thorac Surg 2007 Mar;83(3):1194-6

Department of Cardio-thoracic & Vascular Surgery, Post Graduate Institute of Medical Education & Research, Chandigarh, India.

Intrathoracic teratomas almost always occur in the mediastinum, but occasionally, they may be found in the lung as intrapulmonary teratomas. Intrapulmonary teratomas have histologic findings that are similar to those of teratoma from other sites. Two successive patients with intrapulmonary teratomas presented to us in a variable manner. Read More

Ann Neurol 2007 Jan;61(1):25-36

Department of Neurology, Division of Neuro-oncology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Objective: To report the autoantigens of a new category of treatment-responsive paraneoplastic encephalitis.

Methods: Analysis of clinical features, neuropathological findings, tumors, and serum/cerebrospinal fluid antibodies using rat tissue, neuronal cultures, and HEK293 cells expressing subunits of the N-methyl-D-aspartate receptor (NMDAR).

Results: Twelve women (14-44 years) developed prominent psychiatric symptoms, amnesia, seizures, frequent dyskinesias, autonomic dysfunction, and decreased level of consciousness often requiring ventilatory support. Read More

Appl Immunohistochem Mol Morphol 2006 Sep;14(3):273-5

Department of Pathology, Chang Gung Children Hospital, Taipei, Taiwan.

Primary germ cell tumors (GCTs) and thymoma are both located in the anterior mediastinum. A previous study has postulated that octamer binding transcription factor (OCT4) is a nuclear transcription factor that is expressed in pluripotent embryonic germ cells. This study examined OCT4 expression in GCTs and thymoma originating from the mediastinum. Read More

Radiol Med 2006 Apr 11;111(3):312-42. Epub 2006 Apr 11.

S.C.D.U. Radiologia Diagnostica, Dipartimento di Scienze Cliniche e Biologiche, Università degli Studi di Torino, A.S.O. San Luigi Gonzaga, Regione Gonzole 10, I-10043, Orbassano (TO), Italy.

Mediastinal tumours are frequently asymptomatic and first noted on routine chest radiograph. In most cases, evaluation should proceed to spiral computed tomography (sCT) of the chest with iodinated contrast material. The specific location and appearance of tumours on sCT is instrumental in planning further diagnostic and treatment strategies. Read More

Tuberk Toraks 2005 ;53(3):284-7

Radiology, Gendarmerie Anittepe Clinic, Ankara, Turkey.

An infant who had a cardiac murmur after the delivery was evaluated with echocardiogram. A 1 cm cystic area was incidentally identified in the upper right mediastinum, that was not related with the heart. A 4 x 4. Read More

Childs Nerv Syst 2006 Apr 12;22(4):444-9. Epub 2005 Oct 12.

Department of Neurosurgery, Neurosciences Center, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

Introduction: It is very rare for split cord malformation to be associated with intraspinal teratoma, and it is even rarer for such tumors in the dorsal spine to extend into the mediastinum.

Case Report: The authors describe a spinal teratoma with mediastinal extension in an 8-year-old boy who presented with 1-year history of backache. Neuroimaging revealed a heterogeneously enhancing intradural lesion from D2 to D7 levels with an extension into the mediastinum at the level of D4 vertebra. Read More

An Pediatr (Barc) 2004 Jul;61(1):69-73

Departamento de Pediatría, Hospital Universitario Materno-Infantil Reina Sofía, Córdoba, Spain.

Cardiac tumors are rare neoplasms with an incidence of 0.027 cases per 100. Up to 90 % of these tumors are benign but, because of their location, they can be lethal, despite their histology. Read More

Radiographics 2004 Mar-Apr;24(2):387-404

Department of Radiology, Tsukuba University Hospital, 2-1-1 Amakubo, Tsukuba, Ibaraki 305-8576, Japan.

Germ cell tumors (GCTs) occur most frequently in the gonads and are relatively rare in other sites, such as the pineal gland, neurohypophysis, mediastinum, and retroperitoneum. GCTs are thought to originate from primordial germ cells, which migrate to the primitive gonadal glands in the urogenital ridge. Extragonadal GCTs might also originate from these cells when the cells are sequestered during their migration. Read More

J Thorac Imaging 2003 Jan;18(1):53-5

Department of Radiology, The Ohio State University Medical Center, Columbus, USA.

Mature teratomas in the chest are typically located within the anterior mediastinum. The authors report a case of a mature teratoma in a young adult male with characteristic imaging features except for its location: the posterior mediastinum. On review of the literature, 3% to 8% are reported as confined to the posterior mediastinum and 13% have extension into other mediastinal compartments. Read More

Radiographics 2002 Oct;22 Spec No:S79-93

Department of Radiology B, University Hospital of Strasbourg, 1 place de l'Hôpital, 67091 Strasbourg, France.

Cystic masses of the mediastinum are well-marginated round lesions that contain fluid and are lined with epithelium. Major cystic masses include congenital benign cysts (ie, bronchogenic, esophageal duplication, neurenteric, pericardial, and thymic cysts), meningocele, mature cystic teratoma, and lymphangioma. Many tumors (eg, thymomas, Hodgkin disease, germ cell tumors, mediastinal carcinomas, metastases to lymph nodes, nerve root tumors) can undergo cystic degeneration-especially after radiation therapy or chemotherapy-and demonstrate mixed solid and cystic elements at computed tomography (CT) or magnetic resonance (MR) imaging. Read More

Radiographics 2002 Jan-Feb;22(1):189-216

Department of Radiologic Pathology, Armed Forces Institute of Pathology, 6825 16th St, NW, Bldg 54, Rm M-121, Washington, DC 20306-6000, USA.

Testicular carcinoma represents only 1% of all neoplasms in men, but it is the most common malignancy in the 15-34-year-old age group. Germ cell tumors constitute 95% of all testicular tumors. Germ cell tumors are a varied group of neoplasms whose imaging features reflect their underlying histologic characteristics. Read More

Teratology 2001 Feb;63(2):77-8

Department of Pediatrics, School of Medicine, Ondokuz Mayis University, 55139 Samsun, Turkey.

Background: Teratomas are the most common type of childhood germ cell tumor, arising in both ovary and extragonadal locations. From 40% to 50% of the extragonadal teratomas occur in the sacrococcygeal region. Teratomas in the head, neck, brain, mediastinum, abdominal, and spinal cord locations are seen less frequently. Read More

Masui 2000 May;49(5):535-9

Department of Anesthesiology, Kurume University School of Medicine.

We conducted hemodilutional autotransfusion using a closed circuit combined with a cell washing reinfusing system (Cell Saver) for two surgical patients of Jehovah's Witness. One was a 12 yr-old boy for extirpation of the teratoma in the anterior mediastinum and another was a 44 yr-old woman for left total hip replacement. The patients and their relatives had consented to the use of blood substitutes, hemodilutional autotransfusion using a closed circuit and Cell Saver. Read More

Yonsei Med J 2000 Feb;41(1):136-9

Department of Clinical Pathology, Yonsei University College of Medicine, Seoul, Korea.

Klinefelter syndrome (KS) is often associated with various neoplasms, especially germ cell tumors. Mediastinum is the most favored site of extragonadal germ cell tumors with KS, which is somewhat different from those without KS. The retroperitoneal germ cell tumor in KS is very rare. Read More

Am J Surg Pathol 2000 Feb;24(2):257-73

Department of Pathology, Indiana University School of Medicine, Indianapolis, USA.

A total of 91 men had histologically documented late recurrences of testicular germ cell tumors characterized by a complete response to treatment with a subsequent disease-free interval of at least 2 years and no evidence of a second primary lesion. Ninety percent of the patients for whom information was available received chemotherapy shortly after their initial diagnosis of testicular germ cell tumors; most of the other patients were known to have stage I disease initially. Overall, 60% of patients had teratoma in their late recurrences, including 20 patients (22%) in whom teratoma was the only element. Read More

Kyobu Geka 2000 Feb;53(2):163-6

Department of Thoracic and Cardiovascular Surgery, Nagoya Ekisaikai Hospital, Japan.

A rare case of mature teratoma in both the mediastinum and the intrapulmonary system is presented. A 30-year-old male was admitted to our hospital due to tumor masses in the mediastinum and the left lung. We performed mediastinal tumor resection and left upper partial lobectomy. Read More

Semin Diagn Pathol 1999 Feb;16(1):42-50

Department of Pathology, University of California, San Francisco 94143, USA.

Mediastinal germ-cell tumors (GCTs) usually occur within the anterior mediastinum, accounting for about 15% of all mediastinal cysts and tumors. They are associated with the thymus, presumably arising from extragonadal germ cells or thymic cells with germ-cell potential. Mediastinal seminoma develops primarily in young males with rare cases reported in females; likewise, embryonal carcinoma, endodermal sinus tumor or yolk-sac tumor, choriocarcinoma, and malignant mixed or combined GCTs also overwhelmingly affect males. Read More

Acta Cytol 1995 Jul-Aug;39(4):725-32

Department of Pathology, Niigata University School of Medicine, Japan.

Fine needle aspiration cytology was performed on six patients with malignant mediastinal germ cell tumor: 1 pure seminoma, 1 pure embryonal carcinoma, 1 pure yolk sac tumor and 3 mixed germ cell tumors containing teratoma. Their cytologic features were compared with each other and with the cytologic features of thymoma, which arises commonly in the anterior mediastinum. A definitive cytologic diagnosis could be made only in the cases of seminoma because of its characteristic cytologic features. Read More

Arch Dis Child 1995 Feb;72(2):163-4

Department of Paediatrics, University Hospital, Free University of Brussels, Belgium.

A 5 month old boy with a retroperitoneal teratoma was found to have a 47 XXY karyotype indicating Klinefelter's syndrome. This observation suggests that patients with the syndrome may be at risk of germinal tumours in sites other than those usually reported (mediastinum, brain, and testes). Read More

Genes Chromosomes Cancer 1995 Jan;12(1):8-15

Department of Medical Genetics, University of Groningen, The Netherlands.

Two malignant extragonadal germ cell tumors are reported, histologically classified as immature teratomas, having pseudodiploid karyotypes with complex structural rearrangements but lacking isochromosome 12p or other rearrangements involving 12p. The absence of 12p material in structural rearrangements was confirmed by chromosome painting. In the two tumors the following common chromosomal breakpoints were found: 6p21, 6p22, 6q23, and 11q13. Read More

Hum Pathol 1994 Apr;25(4):349-56

Department of Pathology, Mount Sinai Medical Center, Miami Beach, FL 33140.

Four cases are presented of primary anterior mediastinal tumors in young adults that were characterized by solid, infiltrative lesions showing histologic and immunohistochemical features of rhabdomyoblastic differentiation. The patients were three men and one woman between 19 and 27 years of age (mean age, 23 years). All patients presented with symptoms referable to their tumors, including cough, chest pain, dyspnea, and left-sided pleural effusion. Read More

Afr J Med Med Sci 1994 Mar;23(1):53-60

Department of Pathology, University College Hospital, Ibadan.

Teratomas accounted for 3.4 cases per 1,000 surgical biopsies received in the Pathology Department of UCH Ibadan, between 1960 and 1985. The commonest site of teratomas was in the ovaries which accounted for 83. Read More

Clin Oncol (R Coll Radiol) 1994 ;6(5):345-6

Velindre Hospital, Cardiff, UK.

Mature benign cystic teratomas, or dermoid cysts, usually arise in the ovary. They can, however, occur at other sites, including the mediastinum. Malignant change within dermoid cysts is a rare but recognized complication, occurring in 1%-2% of cases. Read More

Ann Pediatr (Paris) 1993 Dec;40(10):613-21

Laboratoire d'Anatomie Pathologique, Centre Paul Strauss, Strasbourg.

A neonate with an immature, poorly demarcated retroperitoneal teratoma invading the aorta-vena cava space died immediately after surgery. Among 34 cases of retroperitoneal teratoma discovered during the first postnatal month, including one renal case and ours, eight can be considered malignant on the basis of histology in two cases and clinical course in six. Five of these tumors exhibited a significant immature component. Read More

Nihon Kyobu Geka Gakkai Zasshi 1993 Mar;41(3):498-502

Department of Surgery, Nagoya City University School of Medicine, Japan.

We encountered two unusual cases of intrapulmonary teratoma, one in a 31-year-old female and the other in a 15-year-old female. The chief complaint of both patients was fever, and in both a consolidation was detected in the left upper lobe using routine radiography. We performed left upper lobectomy for the former patient and segmentectomy of the left lingual segment for the latter. Read More

Indian J Cancer 1992 Jun;29(2):96-9

Tata Memorial Hospital, Parel, Bombay, India.

This report documents the occurrence of an extragonadal malignant teratoma on the sole of the foot, in a young male. The patient also developed a groin nodule showing the same histology. The testes, retroperitoneum and mediastinum, which are usual sites of germ cell tumours were all normal, and no other primary could be detected. Read More