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Am J Case Rep 2021 Feb 1;22:e930272. Epub 2021 Feb 1.

Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.

BACKGROUND Teratomas are embryonal neoplasms that contain tissues derived from 1 or more of the 3 germ layers. They commonly are found in the sacrococcygeal-gonadal location, sometimes in midline locations such as the mediastinum, retroperitoneum, and head and neck region. Primary rectal teratomas are extremely rare. Read More

J Thorac Cardiovasc Surg 2021 Mar 30;161(3):856-868.e1. Epub 2020 Nov 30.

Division of Thoracic Surgery, Princess Margaret Cancer Center, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Objective: Men with metastatic nonseminomatous germ cell tumors (NSGCTs) often present with residual chest tumors after chemotherapy. We examined the pathologic concordance of intrathoracic disease and outcomes based on the worst pathology of disease resected at first thoracic surgery.

Methods: A retrospective analysis was performed of consecutive patients undergoing thoracic resection for metastatic NSGCT in our institution between 2005 and 2018. Read More

J Thorac Dis 2020 Dec;12(12):7591-7597

Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Tumors in the prevascular compartment of the mediastinum are rare and imaging plays a major role in their detection, (differential) diagnosis, staging, and follow-up. The prevascular compartment is bordered anteriorly by the posterior aspect of the sternum, posteriorly by the ventral aspect of the pericardium, cranially by the thoracic outlet, and caudally by the diaphragm. In many cases, the diagnosis of a lesion in the prevascular compartment is an incidental finding either on chest radiograph (CR) or on computed tomography (CT) scans. Read More

World J Urol 2020 Oct 31. Epub 2020 Oct 31.

Department of Thoracic Surgery, Agaplesion Markus Krankenhaus Frankfurt, Wilhelm-Epstein-Str. 4, 60431, Frankfurt, Germany.

Purpose: Thoracic growing teratoma syndrome (TGTS) is a rare disease in patients with germ cell tumors. Other than a few case reports and a limited number of case series, studies of this topic are not available.

Methods: We retrospectively analyzed the data from our patients who received surgery for TGTS between 1999 and 2016. Read More

Cir Cir 2020 ;88(Suppl 1):19-23

Pathological anatomy service, HRAEO, de Hospital Regional Alta Especialidad de Oaxaca. San Bartolo Coyotepec, Oaxaca, Mexico.

We present the case of a suprahepatic tumor related to mature cystic teratoma, extragonadal germ cell tumors are rare and represent from 1.6 to 5% of all germ cell tumors, the most common site and the extragonadal presentation is the mediastinum (50-70%), retroperitoneum (30-40%), other rare locations pineal gland, sacrococcal region, prostate and bladder; however, the supra-hepatic location is not so common and is not documented in the literature. Read More

J Cardiothorac Surg 2020 Feb 17;15(1):36. Epub 2020 Feb 17.

Department of Thoracic surgery, Peking Union Medical College Hospital, Peking Union Medical College, Dong cheng District, Beijing, 100730, China.

Background: Mediastinal teratoma is a rare disease, many cases were reported before, but few articles focus on large case analyses. The objective of this article is to summarize the clinical characteristics of benign mediastinal teratoma and the experience of surgical treatment, especially thoracoscopic surgery for benign mediastinal teratoma.

Methods: The clinical data of 108 patients with benign mediastinal teratoma confirmed by operation and pathology from January 1992 to January 2018 were analyzed retrospectively. Read More

J Cardiothorac Surg 2019 Jun 20;14(1):113. Epub 2019 Jun 20.

Department of Thoracic surgery, Peking Union Medical College Hospital, Peking Union Medical College, Dongcheng District, Beijing, 100730, China.

Background: Extralobar sequestration is a rare congenital malformation of lung tissue, which can be combined with other foregut and cardiac abnormalities. Our case is the first to report extralobar sequestration, absence of pericardium and atrial septal defect in the same patient.

Case Presentation: A 22-year-old female with atrial septal defect came for her recent atypical symptom of intermittent palpitation and shortness of breath. Read More

Tumori 2018 Dec 6;104(6):NP57-NP60. Epub 2018 Apr 6.

Institute of Radiology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.

Thymolipoma is a rare tumor of the thymus. Classic radiologic findings of thymolipoma include fatty masses of the anterior mediastinum in conjunction with the thymus. Differential diagnosis with other more aggressive entities like liposarcoma and teratoma can be challenging. Read More

J Coll Physicians Surg Pak 2018 03;28(3):243-244

Department of Pathology & Laboratory Medicine, The Aga Khan University and Hospital, Karachi.

Teratomas can be found in different organs of the body and may involve gonads, saccrococcygeal region, mediastinum and other sites. Intrathoracic teratomas always occur in mediastinum and less often arise within the lung. As teratomas mostly involve sex organs (gonads), they rarely occur as extra-gonadal tumors accounting for only 3% of all the cases and very small percentage of such tumors occur in mediastinum. Read More

Diagn Pathol 2016 Aug 15;11(1):76. Epub 2016 Aug 15.

Universidade do Oeste de Santa Catarina, Joaçaba, Brazil.

Background: Germ cell tumors are tumors composed of tissues derived from more than one of the three germinal layers. They are more common in the testes and ovaries, but can present in many different regions in the midline, including the sacral region, retroperitoneum, mediastinum, and brain. Testicular germ cell tumors generally metastasize to the retroperitoneum, lungs, and brain; metastases to soft tissue are very rare. Read More

Pathologe 2016 Sep;37(5):441-8

Institut für Pathologie, Universitätsmedizin Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Deutschland.

The mediastinum is among the most frequent anatomic region in which germ cell tumors (GCT) arise, second only to the gonads. Mediastinal GCT (mGCT) account for 16 % of all mediastinal neoplasms. Although the morphology and (according to all available data) the molecular genetics of mediastinal and gonadal GCT are identical, a number of unique aspects exist. Read More

J Clin Endocrinol Metab 2016 05 10;101(5):1980-8. Epub 2016 Mar 10.

Department of Pediatric Endocrinology, Marmara University Medical School (Z.A., S.T., T.G., A.B.), Istanbul, Turkey; Department of Pediatric Endocrinology, Gulhane Military Medical School (E.Y., E.S.), Ankara Turkey; Department of Pediatric Endocrinology, Dr. Sami Ulus Research Hospital (S.S.E., Z.A., S.C.), Ankara, Turkey; Department of Pediatric Endocrinology, Erciyes University Medical School (L.A., S.K.), Kayseri, Turkey; Department of Pediatric Endocrinology, Uludag University Medical School (E.E., H.S.), Bursa, Turkey; Department of Pediatric Endocrinology, Gazi University Medical School (E.D., A.B.), Ankara, Turkey; Department of Pediatric Endocrinology, Istanbul University Medical School (Z.Y.A.), Istanbul, Turkey; Department of Pediatric Endocrinology, Inonu University Medical School (A.A.), Malatya, Turkey; Department of Pediatric Endocrinology, Ankara University Medical School (Z.S.), Ankara, Turkey; Department of Pediatric Endocrinology, Ege University Medical School (S.O.), Izmir, Turkey; Department of Pediatric Endocrinology, Ondokuz Mayıs University Medical School (C.K.), Samsun, Turkey; Department of Pediatric Endocrinology, Diskapi Research Hospital (M.T.), Ankara, Turkey; Department of Pediatric Endocrinology, Trakya University Medical School (F.T.), Edirne, Turkey; Department of Pediatric Endocrinology, Kocaeli University Medical School (G.S.K.), Kocaeli, Turkey; Department of Pediatric Endocrinology, Karadeniz Technical University Medical School (G.K.), Trabzon, Turkey.

Aim: The causes of gonadotropin-independent precocious puberty are diverse, and often have overlapping clinical and biochemical features. With the exception of congenital adrenal hyperplasia (CAH), disorders that cause gonadotropin-independent precocious puberty (GIPP) are uncommon. The literature is devoid of any large-scale studies on the etiologic distribution of GIPP. Read More

Int J Surg Pathol 2015 Dec 24;23(8):682-4. Epub 2015 Jun 24.

University Hospital of Saint Étienne, Saint Étienne, France

We report the case of a 76-year-old patient presenting with an anterior mediastinal heterogeneous mass. Surgical biopsy revealed a solid and cystic lesion filled with hair. Pathological examination showed an atypical papillary epithelial lining without other germ cell tumor or immature teratoma associated. Read More

Indian J Pathol Microbiol 2013 Apr-Jun;56(2):158-60

Texas Tech University Health Sciences Center - School of Medicine, Lubbock, USA.

The histological predominance of one component in a germ cell tumor can lead to a mistaken diagnosis. Here, we describe a mediastinal teratoma with predominant vascular proliferation (>90%) which on fine needle biopsy was diagnosed as a pulmonary hemangioma. Later, resection specimen revealed other components constituting ~4%, changing the diagnosis while illustrating theimportance of careful evaluation. Read More

Rev Mal Respir 2012 Nov 28;29(9):1111-5. Epub 2012 Sep 28.

Service de chirurgie thoracique, faculté de médecine et de pharmacie de Rabat, université Mohamed V Souissi, hôpital militaire d'instruction Mohamed V, Hay Riad, Rabat, Morocco.

Introduction: Benign cystic mediastinal mass form a group of heterogeneous and uncommon lesions. Surgical resection is the gold standard in these conditions. We reported our institutional experience in management of these benign tumours. Read More

Singapore Med J 2012 Nov;53(11):e237-9

Department of Pathology, Medical College, Kolkata, India.

Intrathoracic teratomas are usually seen in the mediastinum; they rarely occur in the lung as intrapulmonary teratomas. The criteria for pulmonary origin are the exclusion of a gonadal site or other extragonadal primary sites and the exclusive origin of the tumour from the lung. Lung teratomas, for reasons unknown, commonly involve the upper lobe. Read More

Pediatr Dev Pathol 2012 Nov-Dec;15(6):511-3. Epub 2012 Aug 28.

Section of Perinatal Pathology, Department of Pathology, Karolinska University Hospital and Karolinska Institutet, Huddinge, Stockholm, Sweden.

We report a rare case of a primitive embryonal tumor discovered in the upper anterior mediastinum during routine autopsy of a macerated fetus at the 18th week of gestation. Our diagnosis was based on autopsy findings and histologic examination, which showed neuroepithelial differentiation of the tumor with frequent ependymal-type rosette formation; no structures of other germ cell layer origin were revealed. Additional positive immunohistochemical staining for CD56, CD57, and neurofilament protein confirmed the neural origin of the tumor, whereas the genetic analysis showed no MYCN gene amplification and no 11q23 deletion or rearrangement of EWS locus (22q12). Read More

Pediatr Hematol Oncol 2012 Oct 9;29(7):633-42. Epub 2012 Aug 9.

Department of Pediatric Oncology, Institute of Oncology, Hacettepe University, Ankara, Turkey.

Background: Mediastinal germ cell tumors (GCTs) are rare and usually located in anterior mediastinum. We aimed to review clinical and pathological characteristics of these tumors.

Procedure: Between 1973 and 2011, 24 children with mediastinal GCTs were diagnosed. Read More

Ann Thorac Cardiovasc Surg 2011 27;17(6):588-90. Epub 2011 Jul 27.

Department of Thoracic Surgery, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama, Japan.

We present a 12-year-old girl with a teratoma with malignant transformation (TMT) of the mediastinum. Computed tomography showed a cystic mass (5.0 cm × 4. Read More

Chirurgia (Bucur) 2011 Mar-Apr;106(2):199-203

Clinica de Chirurgie Toracica, Institutul Oncologic Prof. Dr. Alexandru Trestioreanu, U.M.E Carol Davila Bucureşti, România.

The posterior mediastinum is the potential space along each side of the vertebral column and adjacent proximal portions of the ribs--the paravertebral sulci. From the posterior mediastinal tumors, the most commonly encountered are the neurogenic tumors (75%), the remaining 25% are represented by a heterogenous group of rare tumors including teratoma, lymphoma, sarcoma and other lesions arising outside the mediastinum and projecting into the posterior compartment. Surgical excision, by thoracotomy or miniinvasive techniques, is the first line of treatment in the posterior mediastinal tumors. Read More

Pediatr Neurosurg 2010 9;46(5):368-72. Epub 2011 Mar 9.

Department of Neurosurgery and Gamma Knife Centre, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Association of split cord malformation with teratoma is an extremely rare condition. It is very unusual to find split cord malformation with teratomas extending into the posterior mediastinum and still rarer to find bony spur arising dorsally and ventrally at the same level.

Case Report: The authors describe the case of a 2-year-old child who presented with dorsal kyphosis and a dermal sinus. Read More

Int J Surg Pathol 2011 Jun 6;19(3):321-7. Epub 2010 Dec 6.

Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

Teratoma with a malignant somatic component (MSC) is a rare phenomenon recognized when a somatic type malignancy occurs in the context of a germ cell tumor (GCT). The authors present their 29-year experience with 40 patients treated from 1981 to 2009 in their institution. The average age was 31 years. Read More

Rev Port Cir Cardiotorac Vasc 2009 Jul-Sep;16(3):143-7

Unidade Local de Saúde do Baixo Alentejo, Serviço de Cirurgia Geral do Hospital de Santo António dos Capuchos, Centro Hospital Lisboa Central.

Mediastinal germ cell tumours (M-GCT) are rare forms of neoplasms compared with other tumours of the same location. They are classified in seminomas, malignant non-seminomatous GCT and teratomas. The malignant transformation of the somatic component of the teratoma, with sarcomatous or carcinomatous degeneration, is even more uncommon. Read More

J Urol 2009 Jun 16;181(6):2526-32. Epub 2009 Apr 16.

Department of Urology and Oncology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Purpose: We determined outcomes in patients with testicular cancer with large volume (greater than 10 cm) retroperitoneal teratoma treated with post-chemotherapy retroperitoneal lymph node dissection.

Materials And Methods: A retrospective review of our testicular cancer database was performed from 1995 to 2005 to identify patients undergoing post-chemotherapy retroperitoneal lymph node dissection for residual masses larger than 10 cm with final pathological examination revealing teratoma. A total of 99 patients met the study inclusion criteria. Read More

Eur J Radiol 2009 Feb 3;69(2):230-5. Epub 2008 Dec 3.

Department of Radiology, Institut Gustave-Roussy, Villejuif, France.

Purpose: To describe the imaging findings of germ cell tumours (GCT) containing non-germ cell malignant components (also designated teratoma with malignant transformation or TMT).

Patients And Methods: The records of 14 male patients with GCT and a non-germ cell histological component TMT were retrospectively reviewed. All patients had computed tomography (CT) and/or magnetic resonance (MR) studies before and after initial surgery and chemotherapy, as well as during follow-up. Read More

Rev Mal Respir 2008 May;25(5):531-8

Service d'Anatomie et de cytologie pathologiques, Hôpital Abderrahman-Mami, Ariana, Tunis, Tunisie.

Introduction: Mature teratomas of the mediastinum are rare. However, they represent the most common mediastinal germ cell tumours. The aim of this study is to describe their clinical and pathological characteristics. Read More

Invest Clin 2007 Dec;48(4):509-14

Unidad de Anatomía Patológica, Instituto Autónomo Hospital Universidad de los Andes, Mérida, Venezuela.

Extragonadal teratomas are more frequent in the mediastinum and sacrococcygeal region. In this work, two cases of mature mediastinal teratoma, that simulated infection processes are reported. These cases appeared during the last semester of the year 2000 and represent the casuistry of the University Hospital of The Andes (IAHULA) between 1996 and 2005. Read More

Zhonghua Bing Li Xue Za Zhi 2007 Oct;36(10):666-71

Department of Pathology, the Children's Hospital of Jiangxi Province, Nanchang 330006, China.

Objective: To study the clinicopathologic features and biologic behavior of pediatric immature teratoma.

Methods: The clinical data, pathologic features, immunohistochemical findings (for cyclin D1, P27 and Ki-67) and follow-up information of 39 cases of pediatric immature teratoma were analyzed.

Results: Amongst the 39 cases studied, 12 arose in the sacrococcygeal region, 12 in testis, 5 in retroperitoneum, 4 in ovary, 4 in abdomen and 2 in mediastinum. Read More