5,736 results match your criteria Teratology and Drug Use During Pregnancy


Automatic classification of label-free cells from small cell lung cancer and poorly differentiated lung adenocarcinoma with 2D light scattering static cytometry and machine learning.

Cytometry A 2018 Dec 3. Epub 2018 Dec 3.

Institute of Biomedical Engineering, School of Control Science and Engineering, Shandong University, Jinan, 250061, China.

Small cell lung cancer (SCLC) needs to be classified from poorly differentiated lung adenocarcinoma (PDLAC) for appropriate treatment of lung cancer patients. Currently, the classification is achieved by experienced clinicians, radiologists and pathologists based on subjective and qualitative analysis of imaging, cytological and immunohistochemical (IHC) features. Label-free classification of lung cancer cell lines is developed here by using two-dimensional (2D) light scattering static cytometric technique. Read More

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December 2018

Histopathological Findings in the Viscera of Malformed Neotropical Viperids.

J Comp Pathol 2018 Nov 28. Epub 2018 Nov 28.

University of São Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Laboratory of Wildlife Comparative Pathology, Av. Orlando Marques de Paiva 87, São Paulo, Brazil.

Congenital malformations (CMs) or developmental abnormalities are pathological processes defined as morphological defects that originate during embryonic stages. A wide variety of CMs is observed in reptiles, most of which are incompatible with normal life. Characterization of CMs and their pathogenesis are of great importance for the conservation of reptiles, including neotropical viperids (NVs). Read More

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November 2018

H. pylori infection induced BMAL1 expression and rhythm disorder aggravate gastric inflammation.

EBioMedicine 2018 Nov 27. Epub 2018 Nov 27.

Department of Microbiology, Key Laboratory for Experimental Teratology of the Chinese Ministry of Education, School of Basic Medical Science, Shandong University, Jinan, Shandong 250012, PR China; Key Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Science, Shandong University, Jinan, Shandong 250012, PR China; Cancer Research Laboratory, Shandong University, Karolinska Institutet collaborative Laboratory, School of Basic Medical Science, Shandong University, Jinan, Shandong 250012, PR China. Electronic address:

Background: Rhythm abnormalities are crucial for diverse diseases. However, their role in disease progression induced by Helicobacter pylori (H. pylori) remains elusive. Read More

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November 2018

The arrogance of teratology: A brief chronology of attitudes throughout history.

Authors:
John M DeSesso

Birth Defects Res 2018 Dec 4. Epub 2018 Dec 4.

Health Sciences Center, Exponent, Alexandria, Virginia.

While the discipline of Teratology has existed for about 60 years, there has been a deep interest in the causes of human malformations for millennia. Absent the scientific method and acting on fervent beliefs that made sense to ancient/medieval populations, "mechanisms" were described and prognostications of future events were assigned to terata resulting in tragic (and unwarranted) sequelae. This article examines the collective beliefs and thinking within various eras in the hope of providing lessons to inform future behavior. Read More

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December 2018

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids.

Cell 2018 Nov;175(6):1591-1606.e19

Oncode Institute, Hubrecht Institute, KNAW (Royal Netherlands Academy of Arts and Sciences), Utrecht, the Netherlands; University Medical Center Utrecht, Cancer Genomics Netherlands, 3584CX Utrecht, the Netherlands; The Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands. Electronic address:

The mammalian liver possesses a remarkable regenerative ability. Two modes of damage response have been described: (1) The "oval cell" response emanates from the biliary tree when all hepatocytes are affected by chronic liver disease. (2) A massive, proliferative response of mature hepatocytes occurs upon acute liver damage such as partial hepatectomy (PHx). Read More

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November 2018
2 Reads

Intellectual functioning in clinically confirmed fetal valproate syndrome.

Neurotoxicol Teratol 2018 Nov 16;71:16-21. Epub 2018 Nov 16.

School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK; Clinical Sciences, Murdoch Children's Research Institute, Flemington Road, Parkville, Victoria 3052, Australia.

Background: An increased risk of impaired intelligence (IQ) has been documented in valproate-exposed children, but investigations have not previously focused on those with a clinical diagnosis of Fetal Valproate Syndrome (FVS).

Methods: This cross sectional observational study recruited individuals with a diagnosis of FVS and completed standardized assessments of intellectual abilities making comparisons to a normative comparison group. Both mean difference (MD) and prevalence of scores below the lower average range were analyzed. Read More

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November 2018
1 Read

Crystal structure and catalytic activity of the PPM1K N94K mutant.

J Neurochem 2018 Nov 19. Epub 2018 Nov 19.

Key Laboratory Experimental Teratology of the Ministry of Education, Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, Shandong, 250012, China.

Protein Phosphatase Mg /Mn Dependent 1K (PPM1K),also named as PP2Cm or branched-chain α-ketoacid dehydrogenase complex phosphatase (BDP), is a member of the metal-dependent phosphatase family and an important metabolic regulator. Single nucleotide polymorphisms (SNPs) in PPM1K contributing to protein functional defects have been found to be associated with numerous human diseases, such as cardiovascular disease, maple syrup urine disease, type 2 diabetes, and neurological disease. PPM1K N94K is an identified missense mutant produced by one of the SNPs in the human PPM1K coding sequence. Read More

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November 2018
2 Reads

CHAF1A interacts with TCF4 to promote gastric carcinogenesis via upregulation of c-MYC and CCND1 expression.

EBioMedicine 2018 Nov 15. Epub 2018 Nov 15.

Department of Microbiology/Key Laboratory for Experimental Teratology of the Chinese Ministry of Education, School of Basic Medical Science, Shandong University, Jinan, Shandong 250012, PR China; Key Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Science, Shandong University, Jinan, Shandong 250012, PR China; Shandong University-Karolinska Institutet Collaborative Laboratory for Cancer Research, Jinan, Shandong 250012, PR China. Electronic address:

Background: Histones chaperones have been found to play critical roles in tumor development and progression. However, the role of histone chaperone CHAF1A in gastric carcinogenesis and its underlying mechanisms remain elusive.

Methods: CHAF1A expression in gastric cancer (GC) was analyzed in GEO datasets and clinical specimens. Read More

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November 2018
2 Reads

The 11p15.5 chromosomal region: When did the instability occur?

Med Hypotheses 2018 Dec 6;121:21-25. Epub 2018 Sep 6.

Department of Nursing and Obstetrics, Division of Health Sciences and Engineering, Campus Celaya-Salvatierra University of Guanajuato, Mexico.

The disturbances of the 11p15.5 chromosomal region are associated with Beckwith-Wiedemann syndrome, Russell-Silver syndrome, Wilms tumor, IMAGe syndrome, and idiopathic hemihyperplasia. The aim of this research was to examine the hypothesis that 11p15. Read More

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December 2018
1 Read

Pan-senescence transcriptome analysis identified RRAD as a marker and negative regulator of cellular senescence.

Free Radic Biol Med 2018 Nov 2;130:267-277. Epub 2018 Nov 2.

Key Laboratory of Experimental Teratology, Ministry of Education, Institute of Molecular Medicine and Genetics, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China; State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University, Suzhou, Jiangsu, China. Electronic address:

Cellular senescence, an irreversible proliferative arrest, functions in tissue remodeling during development and is implicated in multiple aging-associated diseases. While senescent cells often manifest an array of senescence-associated phenotypes, such as cell cycle arrest, altered heterochromatin architecture, reprogrammed metabolism and senescence-associated secretory phenotype (SASP), the identification of senescence cells has been hindered by lack of specific and universal biomarkers. To systematically identify universal biomarkers of cellular senescence, we integrated multiple transcriptome data sets of senescent cells obtained through different in vitro manipulation modes as well as age-related gene expression data of human tissues. Read More

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November 2018
2 Reads

Expression of Micro-RNA-492 (MiR-492) in Human Cervical Cancer Cell Lines is Upregulated by Transfection with Wild-Type P53, Irradiation, and 5-Fluorouracil Treatment In Vitro.

Med Sci Monit 2018 Oct 30;24:7750-7758. Epub 2018 Oct 30.

Laboratory of Cell and Molecular Biology and State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (mainland).

BACKGROUND The status of p53 is critical to the chemoradiosensitivity of cervical cancer cells. Wild-type p53 is essential to orchestrate the cellular response to cytotoxic stimuli. Our previous data illustrated that cervical cancer patients whose specimens overexpressed microR-492 (miR-492) were highly sensitive to concurrent chemoradiation. Read More

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October 2018
1 Read

Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant.

J Med Chem 2018 Nov 6;61(22):9976-9999. Epub 2018 Nov 6.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences , Shandong University , 44 West Culture Road , 250012 Jinan , Shandong , P. R. China.

Due to the emergence of highly pathogenic and oseltamivir-resistant influenza viruses, there is an urgent need to develop new anti-influenza agents. Herein, five subseries of oseltamivir derivatives were designed and synthesized to improve their activity toward drug-resistant viral strains by further exploiting the 150-cavity in the neuraminidases (NAs). The bioassay results showed that compound 21h exhibited antiviral activities similar to or better than those of oseltamivir carboxylate (OSC) against H5N1, H5N2, H5N6, and H5N8. Read More

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November 2018
1 Read
5.450 Impact Factor

Teratological and behavioral screening of the National Toxicology Program 91-compound library in zebrafish (Danio rerio).

Toxicol Sci 2018 Oct 26. Epub 2018 Oct 26.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA.

To screen the tens of thousands of chemicals for which no toxicity data currently exists, it is necessary to move from in vivo rodent models to alternative models, such as zebrafish. Here, we used dechorionated Tropical 5D wildtype zebrafish embryos to screen a 91-compound library provided by the National Toxicology Program (NTP) for developmental toxicity. This library contained 86 unique chemicals that included negative controls, flame retardants, polycyclic aromatic hydrocarbons (PAHs), drugs, industrial chemicals and pesticides. Read More

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October 2018
1 Read

Melatonin enhances atherosclerotic plaque stability by inducing prolyl-4-hydroxylase α1 expression.

J Hypertens 2018 Oct 17. Epub 2018 Oct 17.

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University.

Objective: Melatonin, an endogenous neurohormone secreted predominately by the pineal gland, has a variety of physiological functions. However, its protective role in atherosclerosis is not clear. In this study, we sought to investigate the potential effects of melatonin in modulating atherosclerotic plaque stability in apolipoprotein E knockout (ApoE) mice. Read More

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October 2018
2 Reads

Executive Functioning Correlates With Communication Ability in Youth With Histories of Heavy Prenatal Alcohol Exposure.

J Int Neuropsychol Soc 2018 Nov 16;24(10):1026-1037. Epub 2018 Oct 16.

1Center for Behavioral Teratology and Department of Psychology,San Diego State University,San Diego,California.

Objectives: Caregivers of youth with heavy prenatal alcohol exposure report impaired communication, which can significantly impact quality of life. Using data collected as part of the Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD), we examined whether cognitive variables predict communication ability of youth with histories of heavy prenatal alcohol exposure.

Methods: Subjects (ages 10-16 years) comprised two groups: adolescents with heavy prenatal alcohol exposure (AE) and non-exposed controls (CON). Read More

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November 2018
2 Reads

Prostaglandin E2 facilitates Hepatitis B virus replication by impairing CTL function.

Mol Immunol 2018 Nov 12;103:243-250. Epub 2018 Oct 12.

Key Laboratory for Experimental Teratology of Ministry of Education, Key Laboratory of Infection and Immunity of Shandong Province and Department of Immunology, Shandong University School of Medicine, Jinan, Shandong, 250012, China. Electronic address:

Reversal of T cell dysfunction is a novel and promising approach for the treatment of chronic diseases. PGE2, one of most studied Prostaglandins, exhibits strong and versatile immunoregulation activity on different immune cells including T cells, and has become a promising therapeutic target. Here we found that compared to healthy donors, patients with chronic Hepatitis B virus (HBV) infection had significantly elevated serum PGE2 level. Read More

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November 2018
4 Reads

58th Annual Meeting of the Japanese Teratology Society: Congenital anomalies as variants.

Authors:
Hironao Numabe

Congenit Anom (Kyoto) 2018 Nov 12;58(6):186-187. Epub 2018 Oct 12.

Clinical Genetics Center, Tokyo Medical University Hospital, Tokyo, Japan.

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November 2018

Computational Strategy for Bound State Structure Prediction in Structure-Based Virtual Screening: A Case Study of Protein Tyrosine Phosphatase Receptor Type O Inhibitors.

J Chem Inf Model 2018 Nov 19;58(11):2331-2342. Epub 2018 Oct 19.

Department of Medicinal Chemistry and Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmacy , Shandong University , Jinan , Shandong 250012 , China.

Accurate protein structure in the ligand-bound state is a prerequisite for successful structure-based virtual screening (SBVS). Therefore, applications of SBVS against targets for which only an apo structure is available may be severely limited. To address this constraint, we developed a computational strategy to explore the ligand-bound state of a target protein, by combined use of molecular dynamics simulation, MM/GBSA binding energy calculation, and fragment-centric topographical mapping. Read More

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November 2018
1 Read
3.740 Impact Factor

WDFY4 Is Involved in Symptoms of Systemic Lupus Erythematosus by Modulating B Cell Fate via Noncanonical Autophagy.

J Immunol 2018 Nov 26;201(9):2570-2578. Epub 2018 Sep 26.

Key Laboratory for Experimental Teratology of the Ministry of Education, Shandong University School of Medicine, Jinan, Shandong 250012, China;

Genome-wide association studies have recently illuminated that is genetically associated with systemic lupus erythematosus (SLE) susceptibility in various ethnic groups. Despite strong genetic evidence suggesting a role of in SLE pathogenesis, its functional relevance is largely unknown. In this study, we generated B lymphocyte conditional knockout (-CKO) mice and found that loss of led to a decrease in number of total B cells and several subpopulations of B cells in the periphery and a defect in the transition from the pro- to pre-B cell stage in bone marrow. Read More

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November 2018
6 Reads
4.920 Impact Factor

Tuberous sclerosis complex-mediated mTORC1 overactivation promotes age-related hearing loss.

J Clin Invest 2018 Nov 24;128(11):4938-4955. Epub 2018 Sep 24.

School of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan, China.

The underlying molecular mechanisms of age-related hearing loss (ARHL) in humans and many strains of mice have not been fully characterized. This common age-related disorder is assumed to be closely associated with oxidative stress. Here, we demonstrate that mTORC1 signaling is highly and specifically activated in the cochlear neurosensory epithelium (NSE) in aging mice, and rapamycin injection prevents ARHL. Read More

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November 2018
8 Reads

Hemihyperplasia: History of medicine assists medical genetics.

Homo 2018 Sep 1;69(5):227-236. Epub 2018 Sep 1.

French Department, Alexander Muss High School in Israel (AMHSI) affiliated with Alexander Muss Institute for Israel Education (AMIIE), Hod HaSharon 45102, Israel.

This paper examines the role of the history of medicine in case of congenital isolated hemihyperplasia. Isolated hemihyperplasia is a genetic disorder in which one side of the body grows more than the other, causing visible lateral asymmetry of the human body. The date of the occurrence of the genetic mutation that leads to hemihyperplasia is not known yet. Read More

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September 2018
1 Read

Identification of Genes Associated With Hirschsprung Disease, Based on Whole-Genome Sequence Analysis, and Potential Effects on Enteric Nervous System Development.

Gastroenterology 2018 12 12;155(6):1908-1922.e5. Epub 2018 Sep 12.

Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, China. Electronic address:

Background & Aims: Hirschsprung disease, or congenital aganglionosis, is believed to be oligogenic-that is, caused by multiple genetic factors. We performed whole-genome sequence analyses of patients with Hirschsprung disease to identify genetic factors that contribute to disease development and analyzed the functional effects of these variants.

Methods: We performed whole-genome sequence analyses of 443 patients with short-segment disease, recruited from hospitals in China and Vietnam, and 493 ethnically matched individuals without Hirschsprung disease (controls). Read More

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December 2018
14 Reads

Editorial ETS 2018.

Reprod Toxicol 2018 09;80:10

University of Antwerp, Belgium.

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September 2018

Bifunctional Enzyme SpoT Is Involved in Biofilm Formation of Helicobacter pylori with Multidrug Resistance by Upregulating Efflux Pump Hp1174 ().

Antimicrob Agents Chemother 2018 Nov 24;62(11). Epub 2018 Oct 24.

Department of Microbiology, Key Laboratory for Experimental Teratology of Ministry of Education, Shandong Provincial Key Laboratory of Infection and Immunology, Shandong University School of Basic Medicine, Jinan, Shandong, People's Republic of China

The drug resistance of is gradually becoming a serious problem. Biofilm formation is an important factor that leads to multidrug resistance (MDR) in bacteria. The ability of to form biofilms on the gastric mucosa is known. Read More

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November 2018
1 Read
4.480 Impact Factor

Arctigenin Attenuates Ischemia/Reperfusion Induced Ventricular Arrhythmias by Decreasing Oxidative Stress in Rats.

Cell Physiol Biochem 2018 30;49(2):728-742. Epub 2018 Aug 30.

Department of Pharmacology, Hebei Medical University, Shijiazhuang, China.

Background/aims: Arctigenin (ATG) has been shown to possess anti-inflammatory, immunemodulatory, anti-viral, anti-microbial, anti-carcinogenic, vasodilatory and anti-platelet aggregation properties. However, the protective role of ATG in prevention of arrhythmias induced by myocardial ischemia/reperfusion is unknown. The aim of this study was to investigate the anti-arrhythmia effect of ATG in an ischemia/reperfusion injured rat heart model and explore the related mechanisms. Read More

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September 2018
11 Reads

Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot auto-inhibition and activation.

J Biol Chem 2018 Oct 28;293(42):16226-16241. Epub 2018 Aug 28.

From the Key Laboratory Experimental Teratology of the Ministry of Education, Department of Biochemistry and Molecular Biology, and

Slingshots are phosphatases that modulate cytoskeleton dynamics, and their activities are tightly regulated in different physiological contexts. Recently, abnormally elevated Slingshot activity has been implicated in many human diseases, such as cancer, Alzheimer's disease, and vascular diseases. Therefore, Slingshot-specific inhibitors have therapeutic potential. Read More

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October 2018
9 Reads

Long-term significant seasonal differences in the numbers of new-borns with an orofacial cleft in the Czech Republic - a retrospective study.

BMC Pregnancy Childbirth 2018 Aug 28;18(1):348. Epub 2018 Aug 28.

Department of Teratology, Institute of Experimental Medicine, Czech Academy of Sciences, Videnska 1083, 142 20, Prague 4, Czech Republic.

Background: Choosing the optimal season for conception is a part of family planning since it can positively influence the pregnancy outcome. Changes in the monthly number of infants born with a birth defect can signal prenatal damage - death or malformation - related to a harmful seasonal factor. The aim of our paper was to search for possible seasonal differences in the numbers of new-borns with an orofacial cleft and thus for a period of conception that can increase the risk of orofacial cleft development. Read More

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Ondansetron and teratogenicity in rats: Evidence for a mechanism mediated via embryonic hERG blockade.

Reprod Toxicol 2018 10 24;81:237-245. Epub 2018 Aug 24.

Discipline of Biomedical Sciences, Sydney Medical School, The Unvieristy of Sydney, Sydney, NSW 2006, Australia. Electronic address:

The potent hERG channel blocking drug ondansetron is used off-label for treatment of nausea and vomiting in early pregnancy. Some human epidemiological studies have associated ondansetron with fetal cardiovascular defects and orofacial clefts. This study investigated the effects of ondanestron on embryonic heart rhythm of gestational day (GD) 13 rat embryos in vitro and then integrated the results with published animal teratology, and animal and human pharmacokinetic studies to perform a risk evaluation. Read More

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October 2018
3 Reads

The prevention, screening and treatment of congenital heart block from neonatal lupus: a survey of provider practices.

Rheumatology (Oxford) 2018 07;57(suppl_5):v9-v17

Division of Rheumatology, New York University School of Medicine, NY, USA.

Objective: To survey an international sample of providers to determine their current practices for the prevention, screening, and treatment of congenital heart block (CHB) due to maternal Ro/SSA antibodies.

Methods: A survey was designed by the organizing committee of the 9th International Conference of Reproduction, Pregnancy and Rheumatic Diseases. It was sent to attendants of the conference and authors of recent publications or abstracts at ACR 2012, 2013 or 2014 on rheumatic diseases and pregnancy. Read More

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July 2018
12 Reads

Approach to evaluating pregnancy safety of anti-rheumatic medications in the OTIS MotherToBaby pregnancy studies: what have we learned?

Rheumatology (Oxford) 2018 07;57(suppl_5):v34-v39

Department of Pediatrics, Division of Dysmorphology and Teratology, University of California San Diego, La Jolla, CA, USA.

For the last 30 years, pregnancy exposure studies, with varying methodologies, have been the mainstay of post-marketing surveillance for new drugs likely to be used by women of reproductive age. While they provide valuable data to inform use during pregnancy, they have limitations that render them necessary but not sufficient in supplying timely information to patients and prescribers. The Organization of Teratology Information Specialists MotherToBaby Pregnancy Studies' collaborative research group operates to help fill this gap. Read More

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Factors associated with preterm delivery among women with rheumatoid arthritis and juvenile idiopathic arthritis.

Arthritis Care Res (Hoboken) 2018 Aug 21. Epub 2018 Aug 21.

Departments of Pediatrics and Family Medicine and Public Health, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093.

Objective: Pregnant women with inflammatory arthritis may be at increased risk for preterm delivery (PTD), yet it is unclear what drives this risk. This prospective cohort study of pregnant women with rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), or healthier comparison women analyzed the independent effects of maternal disease activity, medication use, and comorbid pregnancy conditions on PTD risk.

Methods: Women were enrolled before 19 weeks' completed gestation as part of the Organization of Teratology Information Specialists (OTIS) Autoimmune Disease in Pregnancy Project. Read More

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August 2018
3 Reads

Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin.

Nat Chem Biol 2018 Sep 17;14(9):876-886. Epub 2018 Aug 17.

Institute of Biophysics, Chinese Academy of Sciences, Beijing, Chaoyang district, Beijing, China.

Signals from 800 G-protein-coupled receptors (GPCRs) to many SH3 domain-containing proteins (SH3-CPs) regulate important physiological functions. These GPCRs may share a common pathway by signaling to SH3-CPs via agonist-dependent arrestin recruitment rather than through direct interactions. In the present study, F-NMR and cellular studies revealed that downstream of GPCR activation engagement of the receptor-phospho-tail with arrestin allosterically regulates the specific conformational states and functional outcomes of remote β-arrestin 1 proline regions (PRs). Read More

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September 2018
15 Reads

Clinical implications of selective serotonin reuptake inhibitors-selective serotonin norepinephrine reuptake inhibitors pharmacogenetics during pregnancy and lactation.

Pharmacogenomics 2018 Sep 14;19(14):1139-1145. Epub 2018 Aug 14.

Department of Medical Neurobiology, Laboratory of Teratology, Department of Medical Neurobiology, Hadassah Medical School, Hebrew University, Israel.

Depression occurs during pregnancy in 3.9-12.8% of the women. Read More

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September 2018

Oxidative stress-induced miRNAs modulate AKT signaling and promote cellular senescence in uterine leiomyoma.

J Mol Med (Berl) 2018 Oct 10;96(10):1095-1106. Epub 2018 Aug 10.

Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Uterine leiomyomas (ULM) grow under high oxidative stress due to a hypoxic microenvironment and defects in redox metabolism. AKT is one major pathway activated by reactive oxygen species (ROS) that maintains ULM growth and survival. We previously reported that AKT inactivated by AKT inhibitors can significantly induce cellular senescence in ULM cells. Read More

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October 2018
7 Reads

Multiple alleles of ACAN associated with chondrodysplastic dwarfism in Miniature horses.

Anim Genet 2018 Oct 30;49(5):413-420. Epub 2018 Jul 30.

Department of Veterinary Science, MH Gluck Equine Research Center, University of Kentucky, Lexington, KY, 40546, USA.

Chondrodysplastic dwarfism in Miniature horses appeared to be a recessive genetic trait based on the occurrence of affected offspring by normal parents. Dwarf phenotypes vary and range from abnormal abortuses to viable offspring with evidence of skeletal dysplasia. A genome-wide association study implicated a region of ECA1 with dwarfism in Miniature horses. Read More

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October 2018

M. Michael Cohen, Jr.: Author, diagnostician, geneticist, teacher, mentor, syndrome scholar extraordinaire (1937-2018).

Am J Med Genet A 2018 Aug 28;176(8):1703-1705. Epub 2018 Jul 28.

Teratology Unit, Departments of Pediatrics, Pathology and Obstetrics, University of Michigan, Ann Arbor, Michigan.

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August 2018
1 Read

Gut microbiota influences Alzheimer's disease pathogenesis by regulating acetate in Drosophila model.

Future Microbiol 2018 08 25;13:1117-1128. Epub 2018 Jul 25.

Department of Neurology, Huiyang Hospital, Southern Medical University, Huizhou, Guangdong 516211, PR China.

Aim: The aim of present study is to investigate the relationship between gut microbiota and Alzheimer's disease (AD) using Drosophila model.

Materials & Methods: The microbiota was characterized by Illumina sequencing of 16S rRNA gene. Gas chromatography-mass spectrometer was performed to measure the level of short-chain fatty acids (SCFAs), metabolites of the commensal microbiota. Read More

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Oocyte-specific deletion of Gα induces oxidative stress and deteriorates oocyte quality in mice.

Exp Cell Res 2018 Sep 17;370(2):579-590. Epub 2018 Jul 17.

School of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, PR China. Electronic address:

The stimulatory heterotrimeric G protein alpha subunit (Gα) is a ubiquitous guanine nucleotide-binding protein that regulates the intracellular cAMP signaling pathway and consequently participates in a wide range of biological events. In the reproductive system, despite Gα being associated with oocyte meiotic arrest in vitro, the exact role of Gα in female fertility in vivo remains largely unknown. Here, we generated oocyte-specific Gα knockout mice by using the Cre/LoxP system. Read More

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September 2018
2 Reads

Effects of dietary alpha-linolenic acid-enriched diacylglycerol oil on embryo/fetal development in rats.

Regul Toxicol Pharmacol 2018 Oct 27;98:108-114. Epub 2018 Jul 27.

R&D Safety Science Research, Kao Corporation, 2606, Akabane, Ichikai-machi, Haga-gun, Tochigi, 321-3497, Japan.

Recent studies suggest that diets supplemented with alpha-linolenic acid (ALA)-enriched diacylglycerol (DAG) oil provide potential health benefits in preventing or managing obesity. However, available safety information about reproductive and developmental toxicities of ALA-DAG oil is limited. This study was conducted to clarify the effect, if any, of ALA-DAG oil on embryo-fetal development, following maternal exposure during the critical period of major organogenesis. Read More

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October 2018

TCEA1 regulates the proliferative potential of mouse myeloid cells.

Exp Cell Res 2018 Sep 25;370(2):551-560. Epub 2018 Jul 25.

Department of Cell Biology and Key Laboratory of Experimental Teratology, Ministry of Education, Shandong University School of Medicine, Jinan, Shandong, China. Electronic address:

Leukemia is a malignance with complex pathogenesis and poor prognosis. Discovery of noval regulators amenable to leukemia could be of value to gain insight into the pathogenesis, diagnosis and prognosis of leukemia. Here, we conducted a large-scale shRNA library screening for functional regulators in the development of myeloid cells in primary cells. Read More

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September 2018

Histone Acetyltransferase Mof Affects the Progression of DSS-Induced Colitis.

Cell Physiol Biochem 2018 5;47(5):2159-2169. Epub 2018 Jul 5.

The Key Laboratory of Experimental Teratology, Ministry of Education and Department of Cell and Neurobiology, School of Basic Medicine, Jinan, China.

Background/aims: Histone acetylation has been demonstrated to be associated with inflammation response. Histone acetyltransferase (HAT) Mof, specifically acetylating lysine 16 of histone H4 (H4K16), has been reported to regulate T cell differentiation. In addition, it has been suggested that acetylation of H4K16 is associated with the inflammatory response. Read More

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August 2018
28 Reads
2.880 Impact Factor

The novel long noncoding RNA LOC283070 is involved in the transition of LNCaP cells into androgen-independent cells via its interaction with PHB2.

Asian J Androl 2018 Sep-Oct;20(5):511-517

Key Laboratory for Experimental Teratology of the Ministry of Education and Department of Pathology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University; Department of Pathology, Qilu Hospital of Shandong University, Jinan 250012, China.

We sought to investigate the underlying mechanism of action of the long noncoding RNA (lncRNA) LOC283070 in the development of androgen independence in prostate cancer. The interactions between LOC283070 and target proteins were investigated by RNA pull-down and RNA-binding protein immunoprecipitation (RIP) assays. Subcellular fractionation and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) were used to detect the subcellular localization of LOC283070. Read More

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June 2018
6 Reads

Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals.

Mol Psychiatry 2018 Jun 25. Epub 2018 Jun 25.

Neuropsychopharmacology Unit, Centre for Psychiatry, Imperial College London, London, UK.

Addiction has been proposed as a 'reward deficient' state, which is compensated for with substance use. There is growing evidence of dysregulation in the opioid system, which plays a key role in reward, underpinning addiction. Low levels of endogenous opioids are implicated in vulnerability for developing alcohol dependence (AD) and high mu-opioid receptor (MOR) availability in early abstinence is associated with greater craving. Read More

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June 2018
3 Reads
14.500 Impact Factor

A shortened study design for embryo-fetal development studies in the minipig.

Reprod Toxicol 2018 09 22;80:35-43. Epub 2018 Jun 22.

Ellegaard Göttingen Minipigs, Dalmose, Denmark.

The minipig is accepted from scientific and regulatory perspectives for the safety evaluation of drug candidates on embryo-fetal development. The relative size and the duration of gestation (112-115 days) in the minipig is, however, considered a drawback compared with routine smaller species. We evaluated if study duration and cost could be optimized without impacting scientific validity by performing all terminal procedures around mid-gestation (60 days). Read More

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September 2018
2 Reads

Ethical approval for multicenter cohort studies on drug exposure during pregnancy: A survey among members of the European Network of Teratology Information Services (ENTIS).

Reprod Toxicol 2018 Sep 18;80:68-72. Epub 2018 Jun 18.

Swiss Teratogen Information Service and Service of Clinical Pharmacology, University Hospital of Lausanne, Switzerland.

The European Network of Teratology Information Services (ENTIS) is in a privileged position to perform independent post-marketing surveillance of drugs in pregnancy. The aim of this survey was to describe the legal requirements and procedures involved in obtaining ethical approval for collaborative cohort studies. We sent a survey questionnaire to all 28 Teratology Information Services (TIS), of which 25 (89%) in 18 countries completed our questionnaire. Read More

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September 2018
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Pregnancy outcomes after maternal betahistine exposure: A case series.

Reprod Toxicol 2018 Aug 13;79:79-83. Epub 2018 Jun 13.

Terafar - Izmir Katip Celebi University Teratology Information, Training and Research Center, Izmir, Turkey; Izmir Katip Celebi University School of Medicine, Department of Pharmacology Izmir, Turkey.

Objective: To investigate the pregnancy outcomes of women who were exposed to betahistine during their pregnancies.

Methods: We identified and evaluated the outcomes of 27 pregnant women who were referred to Terafar (Teratology Information Service, Izmir, Turkey) for a teratological risk assessment.

Results: Of 24 pregnancies with known outcomes, 21 resulted in live births (including two pairs of twins) whereas two ended with miscarriage and three with elective terminations. Read More

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August 2018
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Decreased Siglec-9 Expression on Natural Killer Cell Subset Associated With Persistent HBV Replication.

Front Immunol 2018 30;9:1124. Epub 2018 May 30.

Key Laboratory for Experimental Teratology of Ministry of Education, Key Laboratory of Infection and Immunity of Shandong Province and Department of Immunology, Shandong University School of Medicine, Jinan, China.

Siglec-9 is an MHC-independent inhibitory receptor selectively expressed on CD56 NK cells. Its role in infection diseases has not been investigated yet. Here, we studied the potential regulatory roles of NK Siglec-9 in the pathogenesis of chronic hepatitis B (CHB) infection. Read More

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May 2018
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Histological and Histochemical Profile for Teratological Assessment in Mus musculus.

Methods Mol Biol 2018 ;1797:507-530

Centro de Ciência Animal e Veterinária (CECAV), Universidade de Trás-os-Montes e Alto Douro (UTAD), Vila Real, Portugal.

Histological analysis of mouse embryos, fetuses, or newborns remains one the most common methods and in some cases the "gold standard" used in teratology studies to detect abnormal morphogenesis during development. Histochemistry methods are based on the selectivity of certain chemical compounds for certain cellular or tissue components, several of them related to specific maturation processes. In this chapter, specific histochemistry techniques that allow for the monitoring of critical stages of tissue and organ formation, such as skeleton and muscle differentiation, neuronal maturation, neuronal connectivity, and neurodevelopment after teratogenic exposure are described in detail. Read More

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January 2018

Western Blot Analysis and Immunostaining for Prediction of Embryotoxicity in Mus musculus.

Methods Mol Biol 2018 ;1797:497-505

Biomedicine Department, Indonesia International Institute for Life Sciences, Jakarta, Indonesia.

A broad range of research must be answered in order to gain a complete understanding of the histological and histochemical profile of teratological exposure in Mus musculus. Continued research is needed to track patterns of teratogen effects on the DNA expression of the embryonic brain and its variation impact. An important technique used in cell and molecular biology is Western blotting. Read More

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January 2018