19,023 results match your criteria Temporal Lobe Epilepsy


Proconvulsant effects of sildenafil citrate on pilocarpine-induced seizures: involvement of cholinergic, nitrergic and pro-oxidant mechanisms.

Brain Res Bull 2019 Apr 17. Epub 2019 Apr 17.

Neuropsychopharmacology Laboratory, Drug Research and Development Center, Faculty of Medicine, Department of Physiology and Pharmacology, Universidade Federal do Ceará, Fortaleza, CE, Brazil; Pharmacy Department, Faculty of Dentistry, Nursing and Pharmacy, Universidade Federal do Ceará, Fortaleza, CE, Brazil. Electronic address:

Sildenafil is a phosphodiesterase 5 inhibitor used for the treatment of erectile dysfunction and pulmonary hypertension. Proconvulsant effect is a serious adverse event associated with sildenafil use. Here, we investigated the possible proconvulsant effects of sildenafil in pilocarpine (PILO)-induced seizures model, which mimics some aspects of temporal lobe epilepsy. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.04.008DOI Listing

Temporal lobe epilepsy: Hippocampal pathology modulates connectome topology and controllability.

Neurology 2019 Apr 19. Epub 2019 Apr 19.

From the Neuroimaging of Epilepsy Laboratory (B.C.B., F.F., M.L., B.C., A.B., N.B.) and Multimodal Imaging and Connectome Analysis Laboratory (B.C.B.), McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Canada; Department of Bioengineering and Electrical and Systems Engineering (S.G., D.S.B.), University of Pennsylvania, Philadelphia; and York Neuroimaging Center (E.J., J.S.), University of York, UK.

Objective: To assess whether hippocampal sclerosis (HS) severity is mirrored at the level of large-scale networks.

Methods: We studied preoperative high-resolution anatomical and diffusion-weighted MRI of 44 temporal lobe epilepsy (TLE) patients with histopathologic diagnosis of HS (n = 25; TLE-HS) and isolated gliosis (n = 19; TLE-G) and 25 healthy controls. Hippocampal measurements included surface-based subfield mapping of atrophy and T2 hyperintensity indexing cell loss and gliosis, respectively. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007447DOI Listing

Redaction of false high frequency oscillations due to muscle artifact improves specificity to epileptic tissue.

Clin Neurophysiol 2019 Apr 11;130(6):976-985. Epub 2019 Apr 11.

Department of Neurology, University of Michigan, USA; Department of Biomedical Engineering, Biointerfaces Institute, University of Michigan, USA. Electronic address:

Objective: High Frequency Oscillations (HFOs) are a promising biomarker of epilepsy. HFOs are typically acquired on intracranial electrodes, but contamination from muscle artifacts is still problematic in HFO analysis. This paper evaluates the effect of myogenic artifacts on intracranial HFO detection and how to remove them. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457193012
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http://dx.doi.org/10.1016/j.clinph.2019.03.028DOI Listing
April 2019
1 Read

Seizure control by low-intensity ultrasound in mice with temporal lobe epilepsy.

Epilepsy Res 2019 Apr 4;154:1-7. Epub 2019 Apr 4.

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China. Electronic address:

Background: Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. Recent studies have demonstrated that ultrasound stimulation can inhibit spontaneous recurrent seizures and improve behavioral outcomes for rodents with TLE. However, the exact underlying mechanism for inhibition of TLE via ultrasound stimulation remains unknown. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.04.002DOI Listing

Similar and Differing Distributions Between F-FDG-PET and Arterial Spin Labeling Imaging in Temporal Lobe Epilepsy.

Front Neurol 2019 3;10:318. Epub 2019 Apr 3.

Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.

Despite the increasing use of arterial spin labeling (ASL) in patients with epilepsy, little is known about its brain regional distribution pattern, including diaschisis, and its correspondence with FDG-PET. Here, we investigated the regional match and mismatch between FDG-PET and ASL in temporal lobe epilepsy (TLE). We recruited 27 patients with unilateral TLE, who underwent inter-ictal ASL and FDG-PET scans. Read More

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http://dx.doi.org/10.3389/fneur.2019.00318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456651PMC

Low-Intensity Pulsed Ultrasound Stimulation Modulates the Nonlinear Dynamics of Local Field Potentials in Temporal Lobe Epilepsy.

Front Neurosci 2019 2;13:287. Epub 2019 Apr 2.

Institute of Electrical Engineering, Yanshan University, Qinhuangdao, China.

Low-intensity pulsed ultrasound stimulation (LIPUS) can inhibit seizures associated with temporal lobe epilepsy (TLE), which is the most common epileptic syndrome in adults and accounts for more than half of the cases of intractable epilepsy. Electroencephalography (EEG) signal analysis is an important method for studying epilepsy. The nonlinear dynamics of epileptic EEG signals can be used as biomarkers for the prediction and diagnosis of epilepsy. Read More

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http://dx.doi.org/10.3389/fnins.2019.00287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454000PMC

Roles of K and Cation Channels in ORL-1 Receptor-mediated Depression of Neuronal Excitability and Epileptic Activities in the Medial Entorhinal Cortex.

Neuropharmacology 2019 Apr 15. Epub 2019 Apr 15.

From Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58203, USA. Electronic address:

Nociceptin (NOP) is an endogenous opioid-like peptide that selectively activates the opioid receptor-like (ORL-1) receptors. The entorhinal cortex (EC) is closely related to temporal lobe epilepsy and expresses high densities of ORL-1 receptors. However, the functions of NOP in the EC, especially in modulating the epileptiform activity in the EC, have not been determined. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.04.017DOI Listing
April 2019
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[Chronic phosphoproteomic in temporal lobe epilepsy mouse models induced by kainic acid].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):197-205

Institute of Systems Biomedicine, State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, Peking University School of Pharmaceutical Science, Beijing 100191, China.

Objective: To investigate functions of proteins and signaling pathways involved in epileptogenesis during the chronic stage of temporal lobe epilepsy in mouse models.

Methods: Kainic acid-induced temporal lobe epilepsy models were conducted, when reaching stage 4 using racine scale, the mice of experimental group were supposed to be successfully established. Pentobarbital sodium was injected to stop epileptic seizure in case of death. Read More

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April 2019
3 Reads

Emotional asymmetries in refractory medial temporal and frontal lobe epilepsy: Their impact on predicting lateralization and localization of seizures.

Epilepsy Behav 2019 Apr 10;94:269-276. Epub 2019 Apr 10.

Department of Neurosurgery, Epilepsy Surgery Unit, School of Medicine, Evangelismos Hospital, University of Athens, Greece.

Background: Emotional disturbances have been reported in patients with epilepsy. Although conflicting results emanate from relevant studies, depressive symptoms are seen more often in temporal lobe epilepsy (TLE) whereas, hypomanic/manic symptoms usually accompany frontal lobe epilepsy (FLE); the above psychiatric symptoms are especially seen in refractory epilepsy. However, neocortical TLE and medial TLE are considered as distinct epileptic syndromes, and there is limited literature on comparison of affective traits in medial TLE (MTLE) and FLE. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.03.008DOI Listing

The epileptic experience in the works of Dostoyevsky and Machado de Assis.

Epilepsy Behav 2019 Apr 9. Epub 2019 Apr 9.

Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil.

Towards the end of the 19th century, two writers who are considered the uppermost representatives of their respective national literatures, Dostoyevsky of Russia and Machado de Assis of Brazil had epilepsy, probably both temporal lobe epilepsy, but their attitudes were opposite. Dostoyevsky was as open about his diagnosis as Machado was secretive, but both included seizure experiences in their works. Two of Dostoyevsky's many epileptic characters, Prince Myshkin in The Idiot and Kirillov in Devils, report the same ecstatic aura as Dostoyevsky did privately. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050193013
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http://dx.doi.org/10.1016/j.yebeh.2019.03.010DOI Listing
April 2019
1 Read

Ictal deafness in drug-resistant MRI-negative epilepsy.

Epileptic Disord 2019 Apr 12. Epub 2019 Apr 12.

Department of Neurosurgery.

Ictal clinical semiology indicates where the patient's seizure arises from and how it progresses. A patient's description of a focal sensory seizure may support a surgical decision even when MRI and PET abnormalities are absent. Ictal deafness is a focal auditory seizure characterized by suppression of hearing, presumably originating from the auditory cortex in the temporal lobe. Read More

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http://dx.doi.org/10.1684/epd.2019.1042DOI Listing
April 2019
4 Reads

Localization value of ictal turning prone.

Seizure 2018 Dec 7;69:57-60. Epub 2018 Dec 7.

Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.

Purpose: Ictal semiology complements ictal EEG in identifying the likely epileptogenic zone. Ictal turning prone (ITP) with body turning of 90 ° or more can be seen with frontal lobe epilepsies. The aim of our study was to evaluate the localizing value of ITP in a general population of patients undergoing long term video-EEG monitoring. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.11.003DOI Listing
December 2018
1 Read

A study of perfusion changes with Insula Epilepsy using SPECT.

Seizure 2019 Mar 28;69:44-50. Epub 2019 Mar 28.

Epilepsy Unit, Department of Neurology, Westmead Hospital and Children's Hospital at Westmead, Hawkesbury Rd, Westmead, NSW, 2145, Australia; Westmead Clinical School, University of Sydney, Hawkesbury Rd, Westmead, NSW, 2145, Australia.

Purpose: The non-invasive localisation of insular lobe epilepsy is a challenge. We aimed to determine if ictal SPECT is a reliable adjunctive test in insular cases and to explore its role in the tailoring of intracranial strategies.

Method: From a dataset of patients who underwent SEEG between December 2012 and December 2016, we collected patients with focal insular onset epilepsy. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.03.021DOI Listing
March 2019
1 Read
2.059 Impact Factor

Seizure characteristics, treatment, and outcome in autoimmune synaptic encephalitis: A long-term study.

Epilepsy Behav 2019 Apr 8;94:198-203. Epub 2019 Apr 8.

Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address:

Objectives: The objective of this study was to report seizure characteristics, long-term outcome, and potential factors associated with persistent seizures in patients with autoimmune synaptic encephalitis (ASE).

Method: Clinical data and courses of 52 patients with ASE who presented with seizures at the Department of Neurology of the First Hospital of Jilin University from January 2015 to August 2017 were reviewed. Seizure outcomes were assessed with a median follow-up duration of 30 months (8-40 months). Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.10.038DOI Listing
April 2019
1 Read

Visuospatial learning and memory in children pre- and posttemporal lobe resection: Patterns of localization and lateralization.

Epilepsy Behav 2019 Apr 7;94:189-194. Epub 2019 Apr 7.

Department of Psychology, University of Toronto Mississauga, Mississauga, ON L5L 1C6, Canada; Neurosciences and Mental Health Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address:

In children with epilepsy, the impact of surgery including or sparing the mesial temporal lobes (TLs) on visuospatial memory has not been thoroughly investigated, and a clear pattern of hemispheric lateralization has not been observed. The primary aim of this study was to examine visuospatial learning and memory outcomes in children with epilepsy prior to and one year after surgical excision, to determine whether outcomes differed as a function of the localization and lateralization of surgical excisions. Forty-six children who underwent unilateral TL surgery with sparing of the mesial structures (TL group, N = 21, 16 left) or including mesial structures (TL + M group, N = 25 children, 12 left) were retrospectively recruited. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.03.031DOI Listing
April 2019
1 Read

Network and Pathway-Based Analysis of Single-Nucleotide Polymorphism of miRNA in Temporal Lobe Epilepsy.

Mol Neurobiol 2019 Apr 9. Epub 2019 Apr 9.

Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.

Temporal lobe epilepsy (TLE) is a complex disease with its pathogenetic mechanism still unclear. Single-nucleotide polymorphisms (SNPs) of miRNA (miRSNPs) are SNPs located on miRNA genes or target sites of miRNAs, which have been proved to be associated with neuropsychic disease development by interfering with miRNA-mediated regulatory function. In this study, we integrated TLE-related risk genes and risk pathways multi-dimensionally based on public data resources. Read More

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http://dx.doi.org/10.1007/s12035-019-1584-4DOI Listing

Association of cerebrospinal fluid zinc-α2-glycoprotein and tau protein with temporal lobe epilepsy and related white matter impairment.

Neuroreport 2019 Apr 5. Epub 2019 Apr 5.

This study aimed to identify the change of cerebrospinal fluid (CSF) zinc-α2-glycoprotein (ZAG), tau protein and phosphorylated tau 181 (P-Tau 181), and analyze their association with white matter impairment (WMI) in patients with temporal lobe epilepsy (TLE). Levels of ZAG, tau, and P-Tau 181 in CSF were measured by enzyme-linked immunosorbent assay. WMI was scored based on Scheltens and Ylikoski scales. Read More

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http://dx.doi.org/10.1097/WNR.0000000000001252DOI Listing
April 2019
1 Read
1.644 Impact Factor

Targeted hippocampal GABA neuron ablation by Stable Substance P-saporin causes hippocampal sclerosis and chronic epilepsy in rats.

Epilepsia 2019 Apr 8. Epub 2019 Apr 8.

Neuroscience Institute, Morehouse School of Medicine, Atlanta, Georgia.

Cryptogenic temporal lobe epilepsy develops in the absence of identified brain injuries, infections, or structural malformations, and in these cases, an unidentified pre-existing abnormality may initiate febrile seizures, hippocampal sclerosis, and epilepsy. Although a role for GABAergic dysfunction in epilepsy is intuitively obvious, no causal relationship has been established. In this study, hippocampal GABA neurons were targeted for selective elimination to determine whether a focal hippocampal GABAergic defect in an otherwise normal brain can initiate cryptogenic temporal lobe epilepsy with hippocampal sclerosis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.14723
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http://dx.doi.org/10.1111/epi.14723DOI Listing
April 2019
8 Reads

Surgically treated intracranial supratentorial calcifying pseudoneoplasms of the neuraxis (CAPNON) with drug-resistant left temporal lobe epilepsy: A case report and review of the literature.

Epilepsy Behav Case Rep 2019 7;11:107-114. Epub 2019 Mar 7.

Department of Neurosurgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka City, Osaka, Japan.

Calcifying pseudoneoplasms of the neuraxis (CAPNON) are rare pathological lesions that can present anywhere in the central nervous system. Symptoms vary depending on the location, though they often include seizures, especially in intracranial and supratentorial lesions. A case of intracranial supratentorial CAPNON presenting with drug-resistant left temporal lobe epilepsy is reported. Read More

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http://dx.doi.org/10.1016/j.ebcr.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434061PMC
March 2019
1 Read

Epilepsy-Induced Reduction in HCN Channel Expression Contributes to an Increased Excitability in Dorsal, But Not Ventral, Hippocampal CA1 Neurons.

eNeuro 2019 Mar-Apr;6(2). Epub 2019 Apr 2.

Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712.

CA1 neurons in epileptic animals are vulnerable to selective changes in ion channel expression, called acquired channelopathies, which can increase the excitability of a neuron. Under normal conditions there is a gradient of ion channel expression and intrinsic excitability along the longitudinal, dorsoventral axis of hippocampal area CA1 of the rodent. Many of these channels, including M-channels, GIRK channels and HCN channels, all have dorsoventral expression gradients that might be altered in rodent models of epilepsy. Read More

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http://dx.doi.org/10.1523/ENEURO.0036-19.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449163PMC
April 2019
1 Read

Connecting Mind, Brain, and Seizures by Default Mode.

Authors:
Jay Salpekar

Epilepsy Curr 2019 Mar-Apr;19(2):103-104

Effective Connectivity Within the Default Mode Network in Left Temporal Lobe Epilepsy: Findings From the Epilepsy Connectome Project Cook CJ, Hwang G, Mathis J, et al. Brain Connect. 2018. Read More

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http://dx.doi.org/10.1177/1535759719837799DOI Listing
April 2019
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The Dilemma of the Chicken or the Egg-What Appears First in TLE-Seizures or Morphometric Changes in the Temporal Lobe?

Epilepsy Curr 2019 Mar-Apr;19(2):101-102

Abnormal Temporal Lobe Morphology in Asymptomatic Relatives of Patients With Hippocampal Sclerosis: A Replication Study Yaakub SN, Barker GJ, Carr SJ, et al. Epilepsia. 2019;60(1):e1-e5. Read More

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http://dx.doi.org/10.1177/1535759719835675DOI Listing

Asymmetric neonatal spasms as an early sign of brain malformation potentially caused by regular light alcohol consumption during the first 22 weeks of pregnancy, a clinical case report.

Dev Period Med 2019 ;23(1):15-20

NICU of Lviv City Children's Hospital.

Objective: Introduction: Epileptic spasms are seizures usually associated with a severe developmental epilepsy syndrome with onset in the first year of life, peaking between 3 and 10 months of age [12]. A variety of disorders can cause epileptic spasms, with the etiology driving management, prognosis, and overall outcome. Preexisting brain damage has been demonstrated in 60% to 90% of the cases reflecting pre-, peri-, or postnatal brain injury that may usually be determined by history and clinical neurologic examination. Read More

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January 2019
1 Read

Establishment of a novel mesial temporal lobe epilepsy rhesus monkey model via intra-hippocampal and intra-amygdala kainic acid injection assisted by neurosurgical robot system.

Brain Res Bull 2019 Apr 4. Epub 2019 Apr 4.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China; Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, China; Beijing Key Laboratory of Neurostimulation, Beijing, 100070, China. Electronic address:

Background: Mesial temporal lobe epilepsy (mTLE) is the most common type of refractory epilepsy, and non-human primate (NHP) models are important to investigate its mechanism and therapy. However, previous mTLE-NHP models have some defects.

Methods: Thirteen rhesus monkeys were randomly assigned to a control group and epilepsy group. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.04.002DOI Listing
April 2019
2 Reads

Association of temporal lobe epilepsy with gambling disorder in a patient with mild intellectual disability and autism spectrum disorder.

Seizure 2019 Mar 28;69:17-19. Epub 2019 Mar 28.

Leicestershire Partnership Trust, Agnes Unit, 400 Anstey Lane, Leicester LE7 7GL, UK; George Davies Centre, 15 Lancaster Rd, Leicester, LE1 7HA. Electronic address:

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http://dx.doi.org/10.1016/j.seizure.2019.03.023DOI Listing
March 2019
1 Read

Infection with HHV-6 and its role in epilepsy.

Epilepsy Res 2019 Mar 29;153:34-39. Epub 2019 Mar 29.

Center for Neuroscience, Children's National Medical Center, George Washington University, 111 Michigan Ave NW, Washington, DC 20010, USA.

Infection with Human Herpesvirus-6 (HHV-6) has been associated with different epilepsy syndromes, including febrile seizures and status epilepticus, acute symptomatic seizures secondary to encephalitis and temporal lobe epilepsy. This neurotropic DNA virus is ubiquitous and primary infection occurs in up to 80% of children by age two years. While two viral variants have been identified, HHV-6B is the one that has been primarily linked to disease in humans, including epilepsy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183062
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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.016DOI Listing
March 2019
3 Reads

The effect of seizure spread to the amygdala on respiration and onset of ictal central apnea.

J Neurosurg 2019 04 5:1-11. Epub 2019 Apr 5.

Departments of Neurology and

Objective: Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death for patients with refractory epilepsy, and there is increasing evidence for a centrally mediated respiratory depression as a pathophysiological mechanism. The brain regions responsible for a seizure’s inducing respiratory depression are unclear—the respiratory nuclei in the brainstem are thought to be involved, but involvement of forebrain structures is not yet understood. The aim of this study was to analyze intracranial EEGs in combination with the results of respiratory monitoring to investigate the relationship between seizure spread to specific mesial temporal brain regions and the onset of respiratory dysfunction and apnea. Read More

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https://thejns.org/view/journals/j-neurosurg/aop/article-10.
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http://dx.doi.org/10.3171/2019.1.JNS183157DOI Listing
April 2019
6 Reads

Divergent network properties that predict early surgical failure versus late recurrence in temporal lobe epilepsy.

J Neurosurg 2019 04 5:1-10. Epub 2019 Apr 5.

Vanderbilt University Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center.

Objective: The objectives of this study were to identify functional and structural network properties that are associated with early versus long-term seizure outcomes after mesial temporal lobe epilepsy (mTLE) surgery and to determine how these compare to current clinically used methods for seizure outcome prediction.

Methods: In this case-control study, 26 presurgical mTLE patients and 44 healthy controls were enrolled to undergo 3-T MRI for functional and structural connectivity mapping across an 8-region network of mTLE seizure propagation, including the hippocampus (left and right), insula (left and right), thalamus (left and right), one midline precuneus, and one midline mid-cingulate. Seizure outcome was assessed annually for up to 3 years. Read More

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http://dx.doi.org/10.3171/2019.1.JNS182875DOI Listing
April 2019
3 Reads
3.737 Impact Factor

Alteration of GABAergic signaling is associated with anxiety-like behavior in temporal lobe epilepsy mice.

Prog Neuropsychopharmacol Biol Psychiatry 2019 Apr 2;93:141-148. Epub 2019 Apr 2.

Department of Pathology, Medical School of Southeast University, Nanjing, China.

Temporal lobe epilepsy (TLE), which is one of the most common neurological diseases, is accompanied by a high incidence of psychiatric disorders. Among these psychiatric disorders, anxiety is one of the major psychiatric comorbidities in epilepsy patients. However, anxiety in epilepsy patients often remains unrecognized and untreated. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2019.03.020DOI Listing
April 2019
2 Reads

Transcriptomic and genetic analyses reveal potential causal drivers for intractable partial epilepsy.

Brain 2019 Apr 1. Epub 2019 Apr 1.

Department of Molecular Neuroscience, UCL, Institute of Neurology, Queen Square, London, UK.

Mesial temporal lobe epilepsy with hippocampal sclerosis represents the most common epilepsy syndrome in adult patients with medically intractable partial epilepsy. Mesial temporal lobe epilepsy is usually regarded as a polygenic and complex disorder, still poorly understood but probably caused and perpetuated by dysregulation of numerous biological networks and cellular functions. The study of gene expression changes by single nucleotide polymorphisms in regulatory elements (expression quantitative trait loci, eQTLs) has been shown to be a powerful complementary approach to the detection and understanding of risk loci by genome-wide association studies. Read More

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http://dx.doi.org/10.1093/brain/awz074DOI Listing
April 2019
5 Reads

Fast ripple analysis in human mesial temporal lobe epilepsy suggests two different seizure-generating mechanisms.

Neurobiol Dis 2019 Mar 27;127:374-381. Epub 2019 Mar 27.

Montreal Neurological Institute and Hospital, McGill University, 3801 University Street, Montreal H3A 2B4, QC, Canada.

Objective: The distinction of hypersynchronous (HYP) and low-voltage fast (LVF) onset seizures in mesial temporal lobe epilepsy (MTLE) is well established, but classifying individual seizures and patients is often challenging. Experimental work indicates a strong association of HYP with fast ripples (250-500 Hz) and of LVF with ripples (80-250 Hz). We aimed to investigate whether analysis of high-frequency oscillations can be useful for characterizing the process of seizure generation in human MTLE patients. Read More

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http://dx.doi.org/10.1016/j.nbd.2019.03.030DOI Listing
March 2019
2 Reads

Cognitive slowing and its underlying neurobiology in temporal lobe epilepsy.

Cortex 2019 Mar 5;117:41-52. Epub 2019 Mar 5.

Neurology, University of Wisconsin-Madison, Madison, WI, USA. Electronic address:

Cognitive slowing is a known but comparatively under-investigated neuropsychological complication of the epilepsies in relation to other known cognitive comorbidities such as memory, executive function and language. Here we focus on a novel metric of processing speed, characterize its relative salience compared to other cognitive difficulties in epilepsy, and explore its underlying neurobiological correlates. Research participants included 55 patients with temporal lobe epilepsy (TLE) and 58 healthy controls from the Epilepsy Connectome Project (ECP) who were administered a battery of tests yielding 14 neuropsychological measures, including selected tests from the NIH Toolbox-Cognitive Battery, and underwent 3T MRI and resting state fMRI. Read More

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http://dx.doi.org/10.1016/j.cortex.2019.02.022DOI Listing
March 2019
1 Read

TrkB-Shc signaling protects against hippocampal injury following status epilepticus.

J Neurosci 2019 Mar 29. Epub 2019 Mar 29.

Department of Neurobiology

Temporal lobe epilepsy (TLE) is a common and commonly devastating form of human epilepsy for which only symptomatic therapy is available. One cause of TLE is an episode of prolonged seizures (status epilepticus, SE). Understanding the molecular signaling mechanisms by which SE transforms a brain from normal to epileptic may reveal novel targets for preventive and disease-modifying therapies. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.2939-18.2019DOI Listing
March 2019
2 Reads

Alzheimer's Disease Including Focal Presentations.

Semin Neurol 2019 Apr 29;39(2):213-226. Epub 2019 Mar 29.

Department of Neurology, Institute of Memory and Alzheimer's Disease, Assistance Publique - Hopitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France.

Alzheimer's disease (AD) is the commonest neurodegenerative disease and the most frequent cause of dementia. It affects 30 million people worldwide. Current research criteria focus on biomarkers' status for amyloid and tau using positron emission tomography and cerebrospinal fluid analysis, independent of clinical status. Read More

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http://dx.doi.org/10.1055/s-0039-1681041DOI Listing
April 2019
2 Reads

Cognitive phenotypes in temporal lobe epilepsy are associated with distinct patterns of white matter network abnormalities.

Neurology 2019 Mar 27. Epub 2019 Mar 27.

From the San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology (A.R.); Center for Multimodal Imaging and Genetics (A.R., E.K., N.B., A.B., C.R.M.) and Department of Psychiatry (C.R.M.), University of California, San Diego; Department of Neurology (M.H., B.M.P.), University of California, San Francisco; UCSF Comprehensive Epilepsy Center (M.H., B.M.P.), San Francisco; Matthews Neuropsychology Section (B.H.), University of Wisconsin-Madison; and UCSD Comprehensive Epilepsy Center (C.R.M.), San Diego, CA.

Objective: To identify distinct cognitive phenotypes in temporal lobe epilepsy (TLE) and evaluate patterns of white matter (WM) network alterations associated with each phenotype.

Methods: Seventy patients with TLE were characterized into 4 distinct cognitive phenotypes based on patterns of impairment in language and verbal memory measures (language and memory impaired, memory impaired only, language impaired only, no impairment). Diffusion tensor imaging was obtained in all patients and in 46 healthy controls (HC). Read More

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http://dx.doi.org/10.1212/WNL.0000000000007370DOI Listing

Trkb-IP3 Pathway Mediating Neuroprotection in Rat Hippocampal Neuronal Cell Culture Following Induction of Kainic Acid.

Malays J Med Sci 2018 Nov 28;25(6):28-45. Epub 2018 Dec 28.

Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

Background: Following brain injury, development of hippocampal sclerosis often led to the temporal lobe epilepsy which is sometimes resistant to common anti-epileptic drugs. Cellular and molecular changes underlying epileptogenesis in animal models were studied, however, the underlying mechanisms of kainic acid (KA) mediated neuronal damage in rat hippocampal neuron cell culture alone has not been elucidated yet.

Methods: Embryonic day 18 (E-18) rat hippocampus neurons were cultured with poly-L-lysine coated glass coverslips. Read More

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http://dx.doi.org/10.21315/mjms2018.25.6.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422567PMC
November 2018

Transition from status epilepticus to interictal spiking in a rodent model of mesial temporal epilepsy.

Epilepsy Res 2019 05 11;152:73-76. Epub 2019 Mar 11.

Montreal Neurological Institute and Departments of Neurology & Neurosurgery, and of Physiology, McGill University, 3801 University Street, Montréal, H3A 2B4, QC, Canada. Electronic address:

Status epilepticus (SE) is a serious, life-threatening condition requiring immediate care to prevent neuronal injury and long-term functional deficits. SE is modeled in rodents by systemic injection of chemoconvulsants such as pilocarpine, which induces EEG and behavioral activities similar to what seen in humans. Combined injection of diazepam and ketamine is commonly used to terminate SE in rodents but, to date, no study has analysed the EEG activity and behavior during SE and after diazepam + ketamine administration. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.005DOI Listing
May 2019
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WIN 55,212-2 Reverted Pilocarpine-Induced Status Epilepticus Early Changes of the Interaction among 5-HT/NMDA/CB Receptors in the Rat Hippocampus.

ACS Chem Neurosci 2019 Mar 26. Epub 2019 Mar 26.

Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery , University of Malta , Msida MSD 2080 , Malta.

The molecular basis for temporal lobe epileptogenesis  remains poorly defined. Recent evidence shows that serotonin 2C receptors (5-HTRs), NR2A and NR2B subunit-containing N-methyl-d-aspartate receptors (NMDARs) and cannabinoid 1 receptors (CBRs) may be involved in the progression of the epileptic disorders. Moreover, CBR activation has been reported to modulate the activity of 5-HT and NMDA receptors. Read More

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http://dx.doi.org/10.1021/acschemneuro.9b00080DOI Listing
March 2019
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Ontogeny and programming of the fetal temporal cortical endocannabinoid system by moderate maternal nutrient reduction in baboons (Papio spp.).

Physiol Rep 2019 Mar;7(6):e14024

Department of Obstetrics and Gynecology, Texas Tech University Health sciences Center at the Permian Basin, Odessa, Texas.

Poor nutrition during pregnancy is a worldwide public health problem. Maternal nutrient reduction (MNR) is associated with maternal and fetal stress and a sex-dependent decrease in nonhuman primate (NHP) cognitive performance. Early life stress potentiates epileptogenesis in a sex-specific manner, and temporal lobe (TL) epilepsy is associated with neurocognitive disorders. Read More

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http://dx.doi.org/10.14814/phy2.14024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434170PMC
March 2019
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The neuropsychological profile of parietal and occipital lobe epilepsy.

Epilepsy Behav 2019 Mar 22;94:137-143. Epub 2019 Mar 22.

Epilepsy Surgery Unit, Department of Neurosurgery, School of Medicine, Evangelismos Hospital, University of Athens, Greece.

Despite the extensive body of research in clinical neurology on the functional organization of posterior cortices, parietal and occipital lobe epilepsy (PLE and OLE) have not as yet received the attention afforded frontal and temporal lobe epilepsy (FLE and TLE), perhaps due to their low prevalence. Posterior epilepsies however, represent a challenge for epileptology in general and neuropsychological differential diagnosis in particular. Our main purpose was to examine the likely existence of a pattern of cognitive dysfunction characterizing patients suffering from seizures with a parietal and/or occipital ictal onset. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.02.021DOI Listing
March 2019
2 Reads

Default mode network deactivation in pediatric temporal lobe epilepsy: Relationship to a working memory task and executive function tests.

Epilepsy Behav 2019 Mar 22;94:124-130. Epub 2019 Mar 22.

University of Wisconsin School of Medicine and Public Health, Madison, WI, United States of America.

Objectives: Children with temporal lobe epilepsy (TLE) exhibit executive dysfunction on traditional neuropsychological tests. There is limited evidence of different functional network alterations associated with this clinical executive dysfunction. This study investigates working memory deficits in children with TLE by assessing deactivation of the default mode network (DMN) on functional Magnetic Resonance Imaging (fMRI) and the relationship of DMN deactivation with fMRI behavioral findings and neuropsychological test performance. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.02.031DOI Listing
March 2019
2.257 Impact Factor

Proliferation of NG2 cells in the epileptic hippocampus.

Epilepsy Res 2019 05 12;152:67-72. Epub 2019 Mar 12.

Radiation Physiology Laboratory, Singapore Nuclear Research and Safety Initiative (SNRSI), National University of Singapore, 1 CREATE Way #04-01, CREATE Tower, 138602, Singapore. Electronic address:

NG2 cells are oligodendrocyte progenitor cells, and have been shown to receive synaptic input from pyramidal neurons to generate action potentials. Whether any change of these cells occurs after status epilepticus (SE) and subsequent temporal lobe epilepsy remains unknown. In the present study, the expression of NG2 was investigated in the mouse hippocampus after pilocarpine-induced status epilepticus (PISE). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183051
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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.006DOI Listing
May 2019
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Frontal lobe dysfunction as a predictor of depression and anxiety following temporal lobe epilepsy surgery.

Epilepsy Res 2019 05 19;152:59-66. Epub 2019 Mar 19.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, United Kingdom; The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom. Electronic address:

Objective: Predictors of psychiatric outcome following TLE surgery have proved elusive and represent a current challenge in the practice of TLE surgery. This prospective study investigated whether frontal lobe dysfunction is predictive of poorer psychiatric outcomes.

Methods: Forty-nine unilateral TLE surgical patients were assessed using the Beck Depression Inventory-Fast Screen (BDI-FS) and Beck Anxiety Inventory (BAI) preoperatively and 6 and 12 months postoperatively. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.003DOI Listing

Consistent linear and non-linear responses to invasive electrical brain stimulation across individuals and primate species with implanted electrodes.

Brain Stimul 2019 Mar 11. Epub 2019 Mar 11.

Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.

Background: Electrical neuromodulation via implanted electrodes is used in treating numerous neurological disorders, yet our knowledge of how different brain regions respond to varying stimulation parameters is sparse.

Objective/hypothesis: We hypothesized that the neural response to electrical stimulation is both region-specific and non-linearly related to amplitude and frequency.

Methods: We examined evoked neural responses following 400 ms trains of 10-400 Hz electrical stimulation ranging from 0. Read More

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http://dx.doi.org/10.1016/j.brs.2019.03.007DOI Listing

REST/NRSF transcription factor is overexpressed in hippocampus of patients with drug-resistant mesial temporal lobe epilepsy.

Epilepsy Behav 2019 Mar 20;94:118-123. Epub 2019 Mar 20.

Departamento de Farmacobiología, Centro de Investigaciones y Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Mexico. Electronic address:

The Repressor Element-1 Silencing Transcription factor or Neuron-Restrictive Silencer Factor (REST/NRSF) is a zinc finger repressor transcription factor of the Kruppel family. Several studies in experimental models have shown that overexpression of REST/NRSF occurs after the induction of seizures. In the present study, the expression of REST/NRSF (messenger ribonucleic acid (mRNA) and protein) was evaluated in the hippocampus of 28 patients with drug-resistant mesial temporal lobe epilepsy (MTLE) and their correlation with clinical variables and comorbid anxiety and depression. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050193001
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http://dx.doi.org/10.1016/j.yebeh.2019.02.012DOI Listing
March 2019
6 Reads

Burr Hole Microsurgery for Intracranial Tumors and Mesial Temporal Lobe Epilepsy: Results of 200 Consecutive Operations.

World Neurosurg 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurooncology, Burdenko Neurosurgery Center, Moscow, Russia.

Objective: Recently, in modern neurosurgery, a tendency toward low-traumatic surgical approaches has become clear. To provide a minimal degree of injury to the brain tissue, we have offered microsurgical approaches through a burr hole.

Methods: From February 2016 to November 2017, 200 microsurgical interventions through a single burr hole with a diameter of 14 mm were performed. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.239DOI Listing

Accuracy of frameless image-guided implantation of depth electrodes for intracranial epilepsy monitoring.

J Neurosurg 2019 03 22:1-11. Epub 2019 Mar 22.

Department of Neurosurgery, University of Utah, Salt Lake City, Utah.

OBJECTIVE: Various techniques are available for stereotactic implantation of depth electrodes for intracranial epilepsy monitoring. The goal of this study was to evaluate the accuracy and effectiveness of frameless MRI-guided depth electrode implantation. METHODS: Using a frameless MRI-guided stereotactic approach (Stealth), depth electrodes were implanted in patients via burr holes or craniotomy, mostly into the medial temporal lobe. Read More

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http://dx.doi.org/10.3171/2018.12.JNS18749DOI Listing
March 2019
2 Reads

Inhibition of ferroptosis processes ameliorates cognitive impairment in kainic acid-induced temporal lobe epilepsy in rats.

Am J Transl Res 2019 15;11(2):875-884. Epub 2019 Feb 15.

Department of Neurology, The First Affiliated Hospital of Guangxi Medical University 6th Shuangyong Road, Nanning, Guangxi, China.

Hippocampal neuronal death plays a causal role in the cognitive impairment of temporal lobe epilepsy (TLE). Ferroptosis, a novel form of regulated cell death, is strongly linked to cognitive impairment. However, whether ferroptosis is associated with cognitive comorbidities of TLE is unknown. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413264PMC
February 2019
9 Reads

BOLD-fMRI activity informed by network variation of scalp EEG in juvenile myoclonic epilepsy.

Neuroimage Clin 2019 Mar 12;22:101759. Epub 2019 Mar 12.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, 610054, China. Electronic address:

Epilepsy is marked by hypersynchronous bursts of neuronal activity, and seizures can propagate variably to any and all areas, leading to brain network dynamic organization. However, the relationship between the network characteristics of scalp EEG and blood oxygenation level-dependent (BOLD) responses in epilepsy patients is still not well known. In this study, simultaneous EEG and fMRI data were acquired in 18 juvenile myoclonic epilepsy (JME) patients. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425117PMC
March 2019
1 Read

Arterial Spin Labeling Reveals Disrupted Brain Networks and Functional Connectivity in Drug-Resistant Temporal Epilepsy.

Front Neuroinform 2018 6;12:101. Epub 2019 Mar 6.

Institute of Nuclear Medicine, University College London, London, United Kingdom.

Resting-state networks (RSNs) and functional connectivity (FC) have been increasingly exploited for mapping brain activity and identifying abnormalities in pathologies, including epilepsy. The majority of studies currently available are based on blood-oxygenation-level-dependent (BOLD) contrast in combination with either independent component analysis (ICA) or pairwise region of interest (ROI) correlations. Despite its success, this approach has several shortcomings as BOLD is only an indirect and non-quantitative measure of brain activity. Read More

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http://dx.doi.org/10.3389/fninf.2018.00101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414423PMC
March 2019
3 Reads