19,815 results match your criteria Temporal Lobe Epilepsy


The efficacy of perampanel as adjunctive therapy in drug-resistant focal epilepsy in a "real world" context: focus on temporal lobe epilepsy.

J Neurol Sci 2020 May 15;415:116903. Epub 2020 May 15.

Institute of Neurology, University "Magna Graecia", Catanzaro, Italy. Electronic address:

Background: Perampanel (PER) is a novel antiepileptic drug approved as an add-on therapy for focal onset seizures with or without generalization and primary generalized tonic-clonic seizures. Aim of this study was to evaluate PER efficacy and tolerability as add-on therapy in patients with drug-resistant focal onset seizures and especially temporal lobe epilepsy (TLE).

Methods: An observational, prospective, multicentre study on adult with drug-resistant focal epilepsy consecutively recruited from six Italian tertiary epilepsy centres. Read More

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http://dx.doi.org/10.1016/j.jns.2020.116903DOI Listing

Investigation of Functional Variability and Connectivity in Temporal Lobe Epilepsy: A Resting State fMRI Study.

Neurosci Lett 2020 May 21:135076. Epub 2020 May 21.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. Electronic address:

It is crucial to reveal the variability between patients with epilepsy and healthy subjects to elucidate the underpinnings of the disease pathology. Herein, we assessed the inter-subject variability between patients with temporal lobe epilepsy (TLE) and healthy subjects in terms of estimating the functional connectivity using resting-state functional magnetic resonance (rs-fMRI) scans. According to inter-subject variability results between healthy and TLE population, the latter showed more variability mainly in frontoparietal control, default mode, dorsal/ventral attention, visual and somatomotor networks in line with the broad seizure onset and propagation pathway. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135076DOI Listing

Desynchronization of temporal lobe theta-band activity during effective anterior thalamus deep brain stimulation in epilepsy.

Neuroimage 2020 May 20:116967. Epub 2020 May 20.

Division of Functional and Restorative Neurosurgery, Department of Neurosurgery, and Tübingen NeuroCampus, University of Tübingen, 72076, Tübingen, Germany. Electronic address:

Background: Bilateral cyclic high frequency deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) reduces the seizure count in a subset of patients with epilepsy. Detecting stimulation-induced alterations of pathological brain networks may help to unravel the underlying physiological mechanisms related to effective stimulation delivery and optimize target engagement.

Methods: We acquired 64-channel electroencephalography during ten ANT-DBS cycles (145Hz, 90μs, 3-5V) of 1-minute ON followed by 5-minutes OFF stimulation to detect changes in cortical activity related to seizure reduction. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2020.116967DOI Listing

Antiepileptic drugs for acute encephalitic patients presented with seizure.

Epilepsy Res 2020 May 19;164:106347. Epub 2020 May 19.

Department of Neurology and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address:

Objective: The aim of this study was to clarify the pattern and efficacy of antiepileptic drugs (AEDs) in acute encephalitis and discuss how long AEDs should be used after the acute phase.

Methods: Patients with acute encephalitis who presented with seizure were enrolled. The clinical features were systematically gathered, and the information about AEDs and seizures was obtained by a clinical follow-up and (or) a telephone interview based on a structured form. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2020.106347DOI Listing

Antagomirs targeting miR-142-5p attenuate pilocarpine-induced status epilepticus in mice.

Exp Cell Res 2020 May 18:112089. Epub 2020 May 18.

Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, PR China.

MicroRNAs (miRNAs) are reported to involve in pathogenesis of temporal lobe epilepsy (TLE). miR-142-5p is found increased in TLE, but its role remains unknown. In the study, we established a mouse model of status epilepticus (SE) with pilocarpine and a cell model of TLE. Read More

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http://dx.doi.org/10.1016/j.yexcr.2020.112089DOI Listing

Epidemiology of traumatic brain injury-associated epilepsy in western China: An analysis of multicenter data.

Epilepsy Res 2020 May 11;164:106354. Epub 2020 May 11.

Department of Neurology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, 610041, Sichuan Province, China. Electronic address:

Objectives: This study aims to explore the probability of developing posttraumatic epilepsy (PTE) in the following 8 years after traumatic brain injury (TBI), the risk factors associated with PTE and its cumulative prevalence.

Methods: This is a retrospective follow-up study of patients with traumatic brain injury (TBI) discharged from the West China Hospital between January 1, 2011 and December 31, 2017, Chengdu Shang Jin Nan Fu Hospital and Sichuan Provincial People's Hospital from January 1, 2013 to March 1, 2015. We used forward stepwise method to build the final multivariate cox proportional hazard regression model to obtain estimates of hazard ratio (HR) of PTE and 95% confidence intervals (CI). Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2020.106354DOI Listing

STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons.

CNS Neurosci Ther 2020 May 21. Epub 2020 May 21.

Department of Neurology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Introduction: A large amount of literature has indicated that excitatory synaptic transmission plays a crucial role in epilepsy, but the detailed pathogenesis still needs to be clarified.

Methods: In the present study, we used samples from patients with temporal lobe epilepsy, pentylenetetrazole-kindled mice, and Mg -free-induced epileptic cultured hippocampal neurons to detect the expression pattern of STK24. Then, the whole-cell recording was carried out after STK24 overexpression in the Mg -free-induced epileptic cultured hippocampal neurons. Read More

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http://dx.doi.org/10.1111/cns.13391DOI Listing

Acute modulation of the limbic network with low and high-frequency stimulation of the human fornix.

Epilepsy Behav Rep 2020 23;14:100363. Epub 2020 Apr 23.

Epilepsy and Cognitive Neurophysiology Laboratory, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.

Targeted stimulation of white matter has opened newer perspectives in the field of neuromodulation, towards an attempt to improve memory or as a therapy for epilepsy. Stimulation of the fornix, being a part of the Papez circuit, is likely to modulate the limbic network excitability. However, the stimulation-frequency dependent variability in network excitability is unknown. Read More

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http://dx.doi.org/10.1016/j.ebr.2020.100363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232081PMC

Endocannabinoid System and Cannabinoid 1 Receptors in Patients With Pharmacoresistant Temporal Lobe Epilepsy and Comorbid Mood Disorders.

Front Behav Neurosci 2020 6;14:52. Epub 2020 May 6.

Department of Pharmacobiology, Center of Research and Advanced Studies, Mexico City, Mexico.

Experimental evidence points out that the activation of the endocannabinoid system induces neuroprotective effects and reduces mood disorders. In the hippocampus of patients with mesial temporal lobe epilepsy (MTLE), studies indicated augmented cannabinoid 1 receptor (CBR) binding, in spite of its low mRNA and protein expressions. Although this situation suggests an enhanced CBR-induced neurotransmission in patients with MTLE, especially those with pharmacoresistant seizures, which present important neuronal damage and high comorbid mood disorders. Read More

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http://dx.doi.org/10.3389/fnbeh.2020.00052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218130PMC

[Ictal EEG pattern of transient epileptic amnesia in acute phase of non-herpetic limbic encephalitis].

Rinsho Shinkeigaku 2020 May 19. Epub 2020 May 19.

Department of Neurology, Japan Community Health care Organization, Hoshigaoka Medical Centre.

A 60-year-old, right-handed woman was admitted to our hospital for amnesia as the only neurological abnormal findings following the autonomic symptoms and transient episodes of loss of awareness. EEG during the amnesia showed rhythmic alpha activity arising from the left mid-temporal region. Although this ictal activity showed evolution in the frequency and amplitude, the location was limited in the bilateral temporal areas. Read More

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http://dx.doi.org/10.5692/clinicalneurol.60.cn-001414DOI Listing

[Dural arteriovenous fistula causing complex visual hallucinations without an anopsia].

Rinsho Shinkeigaku 2020 May 19. Epub 2020 May 19.

Department of Neurology, Brain Research Institute, Niigata University.

We report the case of a 76-year-old woman who presented with recurrent episodes of complex visual hallucinations in her right visual field without an anopsia. The electroencephalogram showed sharp transients in the left parietotemporal region with phase reversals at T5 and P3. FLAIR MRI revealed hyperintense lesions in the left temporo-occipital lobe, located mainly in the left inferior temporal lobe. Read More

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http://dx.doi.org/10.5692/clinicalneurol.60.cn-001371DOI Listing

Pilocarpine-induced status epilepticus reduces chemosensory control of breathing.

Brain Res Bull 2020 May 17;161:98-105. Epub 2020 May 17.

Department of Physiology and Biophysics, Institute of Biomedical Science, University of Sao Paulo, 1524 Prof Lineu Prestes Av 05508-000, Sao Paulo, SP, Brazil. Electronic address:

One of the possible causes of death in epilepsy is breathing disorders, especially apneas, which lead to an increase in CO levels (hypercapnia) and/or a decrease in O levels in arterial blood (hypoxemia). The respiratory neurons located in the ventral brainstem respiratory column are the main groups responsible for controlling breathing. Recent data from our group demonstrated respiratory changes in two experimental models of epilepsy, i. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2020.05.002DOI Listing

Clinical and Electroencephalographic Features of the Seizures in Neuronal Surface Antibody-Associated Autoimmune Encephalitis.

Front Neurol 2020 5;11:280. Epub 2020 May 5.

Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

To investigate clinical and electroencephalographic features of the seizures in different types of neuronal surface antibody (NSAb)-associated autoimmune encephalitis (AE). The clinical data of the seizures were analyzed in 18 patients with NSAb-associated AEs diagnosed in the First Affiliated Hospital of Dalian Medical University. From May 2013 to April 2019, a total of 18 cases of NSAb-associated AE were diagnosed, including 9 cases of leucine-rich glioma-inactivated 1 protein (LGI1) antibody-associated encephalitis, 7 cases of anti--methyl-d-aspartate receptor (NMDAR) encephalitis, and 2 cases of anti-γ-aminobutyric acid B receptor (GABAR) encephalitis. Read More

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http://dx.doi.org/10.3389/fneur.2020.00280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214674PMC

Unique Characteristics of Epilepsy Development in Neurocysticercosis.

Am J Trop Med Hyg 2020 May 18. Epub 2020 May 18.

Department of Neurology and Rehabilitation Medicine, University of Illinois at Chicago, Chicago, Illinois.

The parasitic helminth infection neurocysticercosis (NCC) is the most common cause of adult-acquired epilepsy in the world. Despite the serious consequences of epilepsy due to this infection, an in-depth review of the distinct characteristics of epilepsy due to neurocysticercosis has never been conducted. In this review, we evaluate the relationship between NCC and epilepsy and the unique characteristics of epilepsy caused by NCC. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0485DOI Listing

Neuroprotective and anticonvulsant effects of sinomenine in kainate rat model of temporal lobe epilepsy: Involvement of oxidative stress, inflammation and pyroptosis.

J Chem Neuroanat 2020 May 8:101800. Epub 2020 May 8.

Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Oxidative stress, inflammation and pyroptosis are three of the most important mechanisms in the pathophysiology of temporal lobe epilepsy (TLE). Most people with TLE are refractory to the existing drugs. Sinomenine has shown neuroprotective effects through counteracting oxidative stress, inflammation and pyroptosis. Read More

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http://dx.doi.org/10.1016/j.jchemneu.2020.101800DOI Listing

Macroscale and microcircuit dissociation of focal and generalized human epilepsies.

Commun Biol 2020 May 18;3(1):244. Epub 2020 May 18.

McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, 3801 University Street, Montreal, QC, H3A2B4, Canada.

Thalamo-cortical pathology plays key roles in both generalized and focal epilepsies, but there is little work directly comparing these syndromes at the level of whole-brain mechanisms. Using multimodal imaging, connectomics, and computational simulations, we examined thalamo-cortical and cortico-cortical signatures and underlying microcircuits in 96 genetic generalized (GE) and 107 temporal lobe epilepsy (TLE) patients, along with 65 healthy controls. Structural and functional network profiling highlighted extensive atrophy, microstructural disruptions and decreased thalamo-cortical connectivity in TLE, while GE showed only subtle structural anomalies paralleled by enhanced thalamo-cortical connectivity. Read More

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http://dx.doi.org/10.1038/s42003-020-0958-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234993PMC

Surgery for Radiologically Normal-Appearing Temporal Lobe Epilepsy in a Centre with Limited Resources.

Sci Rep 2020 May 18;10(1):8144. Epub 2020 May 18.

Department of Neurosurgery, Faculty of Medicine, Diponegoro University, Jl Prof. Soedarto, Tembalang, Semarang, Jawa Tengah, Indonesia.

Approximately 26-30% of temporal lobe epilepsy (TLE) cases display a normal-appearing magnetic resonance image (MRI) leading to difficulty in determining the epileptogenic focus. This causes challenges in surgical management, especially in countries with limited resources. The medical records of 154 patients with normal-appearing MRI TLE who underwent epilepsy surgery between July 1999 and July 2019 in our epilepsy centre in Indonesia were examined. Read More

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http://dx.doi.org/10.1038/s41598-020-64968-4DOI Listing

Early volumetric changes of hippocampus and medial prefrontal cortex following medial temporal lobe resection.

Eur J Neurosci 2020 May 18. Epub 2020 May 18.

Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Previous studies have shown that cognitive demands and physical exercise stimulate adult neurogenesis in the dentate gyrus and hippocampus. Recent observations in healthy humans and patients with mild cognitive impairment moreover suggest that training-induced increases in hippocampal volume may be associated with improved memory performance. The corresponding plasticity processes in hippocampal volume may occur on timescales of months to years. Read More

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http://dx.doi.org/10.1111/ejn.14784DOI Listing

Effect of donepezil and memantine on improvement of cognitive function in patients with temporal lobe epilepsy.

J Res Med Sci 2020 18;25:29. Epub 2020 Mar 18.

Department of Neurology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Cognitive impairment is a common complication of patients with temporal lobe epilepsy (TLE). Therefore, the aim of this study was to compare the effects of donepezil and memantine on improving the cognitive function of patients with TLE.

Materials And Methods: In a clinical trial study, 70 patients with TLE were divided into two groups of 35 each: 10 mg doses of donepezil (first group) and memantine (second group) were applied for 16 weeks. Read More

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http://dx.doi.org/10.4103/jrms.JRMS_209_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213001PMC

HAP1 Modulates Epileptic Seizures by Regulating GABAR Function in Patients with Temporal Lobe Epilepsy and in the PTZ-Induced Epileptic Model.

Neurochem Res 2020 May 17. Epub 2020 May 17.

Department of Neurology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

The number of γ-aminobutyric acid type A receptors (GABARs) expressed on the surface membrane and at synaptic sites is implicated in the enhanced excitation of neuronal circuits and abnormal network oscillations in epilepsy. Huntingtin-associated protein 1 (HAP1), a key mediator of pathological alterations in protein trafficking, directly interacts with GABARs and facilitates their recycling back to synapses after internalization from the surface; thus, HAP1 regulates the strength of inhibitory synaptic transmission. Here, we show that HAP1 modulates epileptic seizures by regulating GABAR function in patients with temporal lobe epilepsy (TLE) and in the pentylenetetrazol (PTZ)-induced epileptic model. Read More

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http://dx.doi.org/10.1007/s11064-020-03052-9DOI Listing

Getting older with chronic temporal lobe epilepsy: What memory profile?

Rev Neurol (Paris) 2020 May 14. Epub 2020 May 14.

Epileptology Unit, Public Assistance-Hospitals of Paris, GHU La Pitié-Salpêtrière-Charles Foix, Paris, France; Sorbonne University, Pierre and Marie Curie School of Medicine, Paris, France; Department of Rehabilitation, Public Assistance-Hospitals of Paris, GHU La Pitié-Salpêtrière-Charles Foix, Paris, France; Brain and Spine Institute, Paris, France.

Older adults with epilepsy frequently report changes in memory function, with a concern about degenerative disease. However, the precise limit between memory changes related to the effects of longstanding chronic epilepsy and physiological aging on memory abilities is very difficult to specify. Knowledge about characteristics of physiological cognitive aging, its influence on memory test results, and its interactions with clinical variables related to epileptic disease are therefore essential to interpret memory scores. Read More

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http://dx.doi.org/10.1016/j.neurol.2020.04.011DOI Listing

CREB Protects against Temporal Lobe Epilepsy Associated with Cognitive Impairment by Controlling Oxidative Neuronal Damage.

Neurodegener Dis 2020 May 15:1-13. Epub 2020 May 15.

Departments of Emergency Medicine, The First Hospital of Jilin University, Changchun, China,

Background: Cognitive dysfunction as a common comorbidity of epilepsy often manifests as learning and memory impairments in patients with temporal lobe epilepsy (TLE). The pathogenetic molecular mechanisms underlying epilepsy-associated cognitive dysfunction are incompletely understood. We investigated the role of cAMP response element binding protein (CREB) and its downstream signaling pathways in the pathogenesis of cognitive impairment in mice with TLE. Read More

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http://dx.doi.org/10.1159/000507023DOI Listing

Theta oscillation and functional connectivity alterations related to executive control in temporal lobe epilepsy with comorbid depression.

Clin Neurophysiol 2020 Apr 29;131(7):1599-1609. Epub 2020 Apr 29.

Department of Rehabilitation Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China. Electronic address:

Objective: Depression is widely acknowledged as the most common comorbidity of temporal lobe epilepsy (TLE), and executive control (EC) may be particularly impaired in patients with TLE with comorbid depression. The purpose of this study was to investigate brain network alterations in patients with TLE with or without depression using scalp electroencephalography (EEG), and to explore the potential mechanisms of TLE with comorbid depression.

Methods: Forty patients with TLE and 20 healthy controls (HC) were recruited for administered the BDI-II and HAMD-17 surveys. Read More

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http://dx.doi.org/10.1016/j.clinph.2020.03.038DOI Listing

Perceptions of illness severity in adults with drug-resistant temporal lobe epilepsy.

Epilepsy Behav 2020 May 14;109:107091. Epub 2020 May 14.

School of Nursing, University of California Los Angeles, Los Angeles, CA, United States of America.

Objective: The purpose of this study was to explore how subjective perceptions of illness severity were described by a sample of participants with drug-resistant epilepsy (DRE) who were considering surgery.

Methods: A qualitative methodology, constructivist grounded theory, guided all aspects of the study. Data were collected via 51 semi-structured interviews with 35 adults in our multiethnic sample. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107091DOI Listing

Clinical characteristics of GAD 65 associated autoimmune encephalitis.

Acta Neurol Scand 2020 May 16. Epub 2020 May 16.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, P.R. China.

Objectives: To examine the clinical characteristics of autoimmune encephalitis associated with the glutamate decarboxylase 65 (GAD 65) antibody.

Materials And Methods: Medical records of all patients that diagnosed with GAD65 antibody-associated encephalitis were retrospectively analyzed. Data regarding demographics and symptoms, neurological signs, laboratory and imaging results, treatment and prognosis were collected. Read More

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http://dx.doi.org/10.1111/ane.13281DOI Listing

Effect of miR-124 on PI3K/Akt signal pathway in refractory epilepsy rats.

Cell Mol Biol (Noisy-le-grand) 2020 May 15;66(2):146-152. Epub 2020 May 15.

Department of Neurology, Liaocheng Third People's Hospital, Liaocheng 252000, P.R. China.

This research aimed to investigate the effect of miR-124 on the PI3K/Akt signaling pathway in refractory epilepsy rats. Ten healthy SD rats were selected as a control group, thirty-six successfully established model rats were randomly divided into the model group, mir-124-agomir, mir-124-antagomir, mir-124-agomir+ LY294002 group (combined group), with 9 rats in each group. PI3K or (and) Akt expressions were intervened respectively. Read More

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Status Epilepticus Dynamics Predicts Latency to Spontaneous Seizures in the Kainic Acid Model.

Cell Physiol Biochem 2020 May;54(3):493-507

Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy,

Background/aims: Status epilepticus (SE) might be followed by temporal lobe epilepsy (TLE), a common neurologic disorder characterized by spontaneous recurrent seizures (SRSs). However, the relationship between SE and TLE is still incompletely characterized. For this reason, in a model of TLE we evaluated the lesion extent and the onset of SRSs to determine if they were influenced by the SE dynamics. Read More

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http://dx.doi.org/10.33594/000000232DOI Listing

Epigenetic regulation in mesial temporal lobe epilepsy associated with hippocampal sclerosis.

Neurol India 2020 Mar-Apr;68(2):314-315

Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, India.

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http://dx.doi.org/10.4103/0028-3886.284369DOI Listing

Temporopolar amygdalohippocampectomy: seizure control and postoperative outcomes.

J Neurosurg 2020 May 15:1-10. Epub 2020 May 15.

1Neuroimaging Laboratory (LNI), Department of Neurology.

Objective: The objective of this study was to evaluate the efficacy and safety of a modified surgical approach for the treatment of temporal lobe epilepsy secondary to hippocampal sclerosis (HS). This modified approach, called temporopolar amygdalohippocampectomy (TP-AH), includes a transsylvian resection of the temporal pole and subsequent amygdalohippocampectomy utilizing the limen insula as an anatomical landmark.

Methods: A total of 61 patients who were diagnosed with HS and underwent TP-AH between 2013 and 2017 were enrolled. Read More

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http://dx.doi.org/10.3171/2020.3.JNS192624DOI Listing
May 2020
3.737 Impact Factor

Stereotactic Laser Ablation for Mesial Temporal Lobe Epilepsy: A prospective, multicenter, single-arm study.

Epilepsia 2020 May 15. Epub 2020 May 15.

Medtronic, Louisville, CO, USA.

Objective: To describe the development of the Stereotactic Laser Ablation for Temporal Lobe Epilepsy study protocol in the context of current practice. An ideal treatment for drug-resistant epilepsy remains an ongoing area of research. Although there are several options available, each has challenges that not only make deciding on the appropriate treatment not clear-cut but also create difficulties in designing clinical studies to provide evidence in support of the treatment. Read More

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http://dx.doi.org/10.1111/epi.16529DOI Listing

Post-traumatic Stress Disorder With Flashbacks of an Old Childhood Memory Triggered by Right Temporal Lobe Epilepsy Surgery in Adulthood.

Front Psychiatry 2020 28;11:351. Epub 2020 Apr 28.

Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France.

Background: A plethora of data show that the hippocampus and the amygdala are involved in post-traumatic stress disorder (PTSD). Neural dysfunctions leading to PTSD (e.g. Read More

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http://dx.doi.org/10.3389/fpsyt.2020.00351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198875PMC

Brivaracetam prevents the over-expression of synaptic vesicle protein 2A and rescues the deficits of hippocampal Long-term potentiation in vivo in chronic temporal lobe epilepsy rats.

Curr Neurovasc Res 2020 May 14. Epub 2020 May 14.

Department of Neurology, Tongji University Affiliated Tenth People's Hospital, 200072 Shanghai. China.

Background: Patients with temporal lobe epilepsy (TLE) usually suffer from cognitive deficits and recurrent seizures. Brivaracetam (BRV) is a novel anti-epileptic drugs (AEDs) recently used for the treatment of partial seizures with or without secondary generalization. Different from other AEDs, BRV has some favorable properties on synaptic plasticity. Read More

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http://dx.doi.org/10.2174/1567202617666200514114917DOI Listing

How to carry out and interpret EEG recordings in COVID-19 patients in ICU?

Clin Neurophysiol 2020 May 13. Epub 2020 May 13.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

There are questions and challenges regarding neurologic complications in COVID-19 patients. EEG is a safe and efficient tool for the evaluation of brain function, even in the context of COVID-19. However, EEG technologists should not be put in danger if obtaining an EEG does not significantly advance diagnosis or change management in the patient. Read More

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http://dx.doi.org/10.1016/j.clinph.2020.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217782PMC

LncRNA ILF3-AS1 mediated the occurrence of epilepsy through suppressing hippocampal miR-212 expression.

Aging (Albany NY) 2020 May 13;12(9):8413-8422. Epub 2020 May 13.

Department of Neurology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Increased expression of some matrix metalloproteinases (MMPs) is closely associated with epilepsy. However, factors that promote their expression have not been clarified. Long noncoding RNAs (lncRNAs) play crucial roles in the development of human diseases, including various cancers, but its potential function in temporal lobe epilepsy (TLE) has remained unexplored. Read More

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http://dx.doi.org/10.18632/aging.103148DOI Listing

Lateralization of epilepsy using intra-hemispheric brain networks based on resting-state MEG data.

Hum Brain Mapp 2020 May 13. Epub 2020 May 13.

Department of Biomedical Engineering, University of Memphis, Memphis, Tennessee, USA.

Focal epilepsy originates within networks in one hemisphere. However, previous studies have investigated network topologies for the entire brain. In this study, magnetoencephalography (MEG) was used to investigate functional intra-hemispheric networks of healthy controls (HCs) and patients with left- or right-hemispheric temporal lobe or temporal plus extra-temporal lobe epilepsy. Read More

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http://dx.doi.org/10.1002/hbm.24990DOI Listing

Anti-seizure therapy with a long-term, implanted intra-cerebroventricular delivery system for drug-resistant epilepsy: A first-in-man study.

EClinicalMedicine 2020 May 3;22:100326. Epub 2020 May 3.

Cerebral Therapeutics, 12635 E. Montview Blvd., Aurora, CO 80010, Australia.

Background: A clinical feasibility study was undertaken at a single center of long-term intra-cerebroventricular drug delivery of the anti-seizure medication valproic acid, into the cerebrospinal fluid (CSF) in order to treat drug resistant focal seizures, using an implantable infusion system. The primary objective was to establish the dose range of VPA administered in this manner. Secondarily, safety, pharmacokinetics (PK) and a preliminary estimate of effectiveness were evaluated. Read More

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http://dx.doi.org/10.1016/j.eclinm.2020.100326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205744PMC

Calcifying pseudoneoplasm of the neuroaxis presenting with refractory seizures: Case report and literature review.

J Clin Neurosci 2020 May 6. Epub 2020 May 6.

Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Calcifying pseudoneoplasms of the neuraxis (CAPNON) are rare benign lesions that can arise anywhere within the central nervous system. The etiology of these lesions remains unknown and diagnosis is made on pathohistological analysis. We present the case of a 35-year-old male patient with a history of epilepsy since childhood who was evaluated for refractory seizures. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.05.001DOI Listing

Personality disorders in temporal lobe epilepsy: What do they signify?

Acta Neurol Scand 2020 May 9. Epub 2020 May 9.

R.Madhavan Nayar Center for Comprehensive Epilepsy Care, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.

Objectives: To estimate the prevalence of personality disorders in patients with TLE with mesial temporal sclerosis (MTS) and compare it with general population and analyze their implications on treatment outcome.

Materials And Methods: TLE was diagnosed based on clinical history, MRI and VEEG data. IPDE-ICD10 screening questionnaire was applied to investigate personality disorder in 120 subjects, 60 cases and 60 normal controls. Read More

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http://dx.doi.org/10.1111/ane.13259DOI Listing

MicroRNA-15a-5p serves as a potential biomarker and regulates the viability and apoptosis of hippocampus neuron in children with temporal lobe epilepsy.

Diagn Pathol 2020 May 8;15(1):46. Epub 2020 May 8.

Department of Medical Insurance, Weifang Maternal and Child Health Care Hospital, Weifang, Shandong, 261021, P.R. China.

Background: Temporal lobe epilepsy (TLE) is the most common type of epilepsy, usually starting in childhood. The dysregulation of microRNAs (miRNAs) has been identified in neurological disorders. The current study investigated the expression level and clinical significance of miR-15a-5p in TLE children, and explored its function in regulating cell behaviors of hippocampal neurons. Read More

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http://dx.doi.org/10.1186/s13000-020-00944-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206675PMC
May 2020
2.411 Impact Factor

Hippocampal shape is associated with memory deficits in temporal lobe epilepsy.

Ann Neurol 2020 May 7. Epub 2020 May 7.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, Queen Square, London, WC1N 3BG, United Kingdom.

Objectives: Cognitive problems, especially disturbances in episodic memory, and hippocampal sclerosis are common in temporal lobe epilepsy (TLE) but little is known about the relationship of hippocampal morphology with memory. We aimed to relate hippocampal surface-shape patterns to verbal and visual learning.

Methods: We analysed hippocampal surface shapes on high-resolution MRI images and the Adult Memory and Information Processing Battery in 145 unilateral refractory TLE patients undergoing epilepsy surgery, a validation set of 55 unilateral refractory TLE patients and 39 age- and sex-matched healthy volunteers. Read More

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http://dx.doi.org/10.1002/ana.25762DOI Listing

Retrospective Analysis of the Test of Memory Malingering in a Low Intellectual Quotient Intractable Epilepsy Sample.

Arch Clin Neuropsychol 2020 May 6. Epub 2020 May 6.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

Objective: The Test of Memory Malingering (TOMM) is commonly used by neuropsychologists (Sharland, M. J., & Gfeller, J. Read More

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http://dx.doi.org/10.1093/arclin/acaa022DOI Listing

Evaluation of the neuroprotective, anticonvulsant, and cognition-improvement effects of apigenin in temporal lobe epilepsy: Involvement of the mitochondrial apoptotic pathway.

Iran J Basic Med Sci 2019 Jul;22(7):752-758

Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Objectives: Cognitive deficit is a common problem in epilepsy. A major concern emergent from the use of antiepileptic drugs includes their side effects on learning and memory. Herbal medicine is considered a complementary and alternative therapy in epilepsy. Read More

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http://dx.doi.org/10.22038/ijbms.2019.33892.8064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196342PMC

Gelatinase Biosensor Reports Cellular Remodeling During Epileptogenesis.

Front Synaptic Neurosci 2020 21;12:15. Epub 2020 Apr 21.

IGF, Université de Montpellier, CNRS, INSERM, Montpellier, France.

Epileptogenesis is the gradual process responsible for converting a healthy brain into an epileptic brain. This process can be triggered by a wide range of factors, including brain injury or tumors, infections, and status epilepticus. Epileptogenesis results in aberrant synaptic plasticity, neuroinflammation and seizure-induced cell death. Read More

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http://dx.doi.org/10.3389/fnsyn.2020.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186352PMC

Identifying the characteristics of brain glucose metabolism using normal F-FDG PET database in patients with temporal lobe epilepsy.

Neurol Sci 2020 May 6. Epub 2020 May 6.

Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.

Objectives: This study aimed to measure the global brain glucose metabolism of patients with temporal lobe epilepsy (TLE) using MIMneuro software based on the normal brain glucose metabolism database.

Methods: In this cross-sectional study, 23 patients (11 males and 12 females, mean age 25.6 ± 10. Read More

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http://dx.doi.org/10.1007/s10072-020-04426-1DOI Listing

Ecstatic and gelastic seizures relate to the hypothalamus.

Epilepsy Behav Rep 2020 21;14:100358. Epub 2020 Mar 21.

Department of Neuroscience, Neurology, Uppsala University, University Hospital, Uppsala, Sweden.

Ecstatic seizures constitute a rare form of epilepsy, and the semiology is diverse. Previously, brain areas including the temporal lobe and the insula have been identified to be involved in clinical expression. The aim of this report is to review changes in ecstatic seizures in a patient before and after operation of a hypothalamic hamartoma, and to scrutinize the relation to gelastic seizures. Read More

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http://dx.doi.org/10.1016/j.ebr.2020.100358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186513PMC

Gelastic seizures: a retrospective study in five tertiary hospital centres.

Epileptic Disord 2020 Apr;22(2):165-175

Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN), Lisbon,, Faculdade de Medicina, Universidade de Lisboa, Lisbon.

This study aimed to characterize, clinically and neurophysiologically, a series of patients with gelastic seizures (GS), including both adults and children. We retrospectively collected patients with GS from epilepsy clinics of five tertiary hospital centres within a single country. Patients were selected through relatives'/caregivers' descriptions, home video and/or video-EEG monitoring. Read More

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http://dx.doi.org/10.1684/epd.2020.1153DOI Listing

Cognitive phenotypes in temporal lobe epilepsy utilizing data- and clinically driven approaches: Moving toward a new taxonomy.

Epilepsia 2020 May 4. Epub 2020 May 4.

San Diego State University, University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.

Objective: To identify cognitive phenotypes in temporal lobe epilepsy (TLE) and test their reproducibility in a large, multi-site cohort of patients using both data-driven and clinically driven approaches.

Method: Four-hundred seven patients with TLE who underwent a comprehensive neuropsychological evaluation at one of four epilepsy centers were included. Scores on tests of verbal memory, naming, fluency, executive function, and psychomotor speed were converted into z-scores based on 151 healthy controls (HCs). Read More

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http://dx.doi.org/10.1111/epi.16528DOI Listing

Clinical utility of structural connectomics in predicting memory in temporal lobe epilepsy.

Neurology 2020 May 1. Epub 2020 May 1.

From the Center for Multimodal Imaging and Genetics (A.R.B., E.K., N.B., A.R., A.C.M., C.R.M.) and Department of Psychiatry (C.R.M.), University of California, San Diego; San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology (A.R., C.R.M.); Department of Neurology (S.L., B.M.P.), University of California, San Francisco; Department of Neurology (L.B.), Medical University of South Carolina, Charleston; and Boston University School of Medicine (A.R.B.), MA.

Objective: To determine the predictive power of white matter neuronal networks (i.e., structural connectomes [SCs]) in discriminating memory-impaired patients with temporal lobe epilepsy (TLE) from those with normal memory. Read More

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http://dx.doi.org/10.1212/WNL.0000000000009457DOI Listing

Functional MRI (fMRI) human mapping for indicating hippocampal content-specific responsivity and laterality.

Neuropsychology 2020 Apr 30. Epub 2020 Apr 30.

Sagol Brain Institute, Tel Aviv Sourasky Medical Center.

Objective: Presurgical memory functional MRI (fMRI) mapping for temporal lobe epilepsy surgery is important because of the excision of structures in the temporal lobe (e.g., hippocampus) that are relevant for intact memory. Read More

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http://dx.doi.org/10.1037/neu0000634DOI Listing

Magnetic resonance-guided focused ultrasound for mesial temporal lobe epilepsy: a case report.

BMC Neurol 2020 Apr 29;20(1):160. Epub 2020 Apr 29.

Department of Neurosurgery, Moriyama Neurological Center Hospital, Tokyo, Japan.

Background: We report the first case of transcranial magnetic resonance-guided focused ultrasound (MRgFUS) for mesial temporal lobe epilepsy (MTLE).

Case Presentation: The target was located 20 mm lateral from the midline and 15 mm above the skull base (left hippocampus). Despite the application of maximal energy, the ablation temperature did not exceed 50 °C, probably because of the low number of effective transducer elements with incident angles below 25 degrees. Read More

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http://dx.doi.org/10.1186/s12883-020-01744-xDOI Listing