18,912 results match your criteria Temporal Lobe Epilepsy


A Preliminary Study Evaluating the Safety and Efficacy of Bumetanide, an NKCC1 Inhibitor, in Patients with Drug-Resistant Epilepsy.

CNS Drugs 2019 Feb 19. Epub 2019 Feb 19.

Department of Neuroscience and Addiction Study, School of Advanced Technologies in Medicine, International Campus, Tehran University of Medical Sciences, Tehran, Iran.

Background: Dysregulation of cation-chloride cotransporters NKCC1 and KCC2 expression was shown to be related to drug-resistant epilepsy. Previous studies suggested that bumetanide, an inhibitor of NKCC1, might have antiepileptic effects.

Objective: The aim of this study was to investigate the safety and efficacy of bumetanide add-on therapy in patients with drug-resistant epilepsy and its relation to cation-chloride cotransporters NKCC1 and KCC2. Read More

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http://link.springer.com/10.1007/s40263-019-00607-5
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http://dx.doi.org/10.1007/s40263-019-00607-5DOI Listing
February 2019
1 Read

Large-Scale 3-5 Hz Oscillation Constrains the Expression of Neocortical Fast Ripples in a Mouse Model of Mesial Temporal Lobe Epilepsy.

eNeuro 2019 Jan-Feb;6(1). Epub 2019 Feb 12.

Functional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University of Geneva, 1202 Geneva, Switzerland.

Large-scale slow oscillations allow the integration of neuronal activity across brain regions during sensory or cognitive processing. However, evidence that this form of coding also holds for pathological networks, such as for distributed networks in epileptic disorders, does not yet exist. Here, we show in a mouse model of unilateral hippocampal epilepsy that epileptic fast ripples generated in the neocortex distant from the primary focus occur during transient trains of interictal epileptic discharges. Read More

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http://dx.doi.org/10.1523/ENEURO.0494-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378326PMC
February 2019

Are psychogenic nonepileptic seizures risk factors for a worse outcome in patients with refractory mesial temporal epilepsy submitted to surgery? Results of a retrospective cohort study.

Epilepsy Behav 2019 Feb 16;93:12-15. Epub 2019 Feb 16.

Department of Psychiatry and Medical Psychology, Faculdade de Medicina de São José do Rio Preto (FAMERP), Brazil. Electronic address:

Objective: The objective of this study was to verify if the presence of psychogenic nonepileptic seizures (PNES) could be a risk factor precluding corticoamygdalohippocampectomy (CAH) in patients with refractory temporal lobe epilepsy (TLE) and mesial temporal sclerosis (MTS) (TLE-MTS).

Methods: This retrospective cohort study analyzed medical data of patients with refractory TLE-MTS accompanied in a Brazilian epilepsy surgery center. Presurgical psychiatric evaluations were performed using the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.036DOI Listing
February 2019

Automated epileptic seizure detection based on break of excitation/inhibition balance.

Comput Biol Med 2019 Feb 10;107:30-38. Epub 2019 Feb 10.

Bio, Electro And Mechanical Systems (BEAMS), Université Libre de Bruxelles (ULB), Brussels, Belgium. Electronic address:

Physiological models are attractive for seizure detection, as their parameters are related to physiological meanings. We propose an algorithm to early detect epileptic seizures based on automatic estimation of average synaptic gains (excitatory Ae, slow and fast inhibitory B and G) by combining clinical data with a neural mass model. Three indices (Ae/B, Ae/G and Ae/(B + G)), all related to excitation/inhibition balance, were calculated and used as cues to detect seizures. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.02.005DOI Listing
February 2019
2 Reads

Impaired prefrontal cortex-thalamus pathway in intractable temporal lobe epilepsy with aberrant executive control function: MRI evidence.

Clin Neurophysiol 2019 Jan 18;130(4):484-490. Epub 2019 Jan 18.

Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, PR China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, PR China. Electronic address:

Objectives: This study aimed to assess structural and functional connectivity alterations of the prefrontal cortex (PFC)-thalamus axis in individuals with unilateral intractable temporal lobe epilepsy (TLE) showing executive control function (ECF) impairment and to explore the potential mechanism.

Methods: Thirty-eight individuals with intractable left TLE and twenty-nine healthy controls (HCs) were recruited for diffusion tensor imaging (DTI) and resting-state fMRI (rs-fMRI) scanning. According to the ECF state, patients were assigned to normal and impaired ECF groups. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.12.007DOI Listing
January 2019
1 Read
3.097 Impact Factor

Inhibitory effects of glucagon-like peptide-1 receptor on epilepsy.

Biochem Biophys Res Commun 2019 Feb 12. Epub 2019 Feb 12.

Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Number 1, Youyi Road Yuzhong District, 400042, Chongqing, China. Electronic address:

Glucagon-like peptide-1 (GLP-1) and its receptor, GLP-1R, are valuable tools in the therapy of type 2 diabetes mellitus. Although GLP-1R stimulation is also potentially applicable to neurological disorders, few investigators have evaluated its beneficial effects in neurological disease models. Thus, we aimed to look into the antiepileptic effects of GLP-1R on epilepsy and its underlying mechanisms. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.02.028DOI Listing
February 2019

The effect of medial pulvinar stimulation on temporal lobe seizures.

Epilepsia 2019 Feb 14. Epub 2019 Feb 14.

Clinical Neurophysiology and Epileptology Department, Timone Hospital, Assitance Publique Hôpitaux de Marseille, Marseille, France.

We investigated the effect of electrical stimulation of the medial pulvinar (PuM) in terms of its effect on temporal lobe seizures. Eight patients with drug-resistant temporal lobe epilepsy undergoing stereoelectroencephalographic exploration were included. All had at least one electrode exploring the PuM. Read More

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http://dx.doi.org/10.1111/epi.14677DOI Listing
February 2019
1 Read

The analysis of risk factors and survival outcome for Chinese high-grade glioma patients with epilepsy.

World Neurosurg 2019 Feb 11. Epub 2019 Feb 11.

Glioma Surgery Division, Neurological Surgery Department of Huashan Hospital, Fudan University, Shanghai, 200040, China. Electronic address:

Objective: To evaluate the risk factors of tumor related epilepsy (TRE) and the relationship between TRE and functional/survival outcomes in high-grade glioma (HGG) patients.

Method: The clinical data of 587 patients with HGG were retrospectively analyzed. Chi-square test and logistic multiple regression analysis were used to analyze factors associated with TRE. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193032
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http://dx.doi.org/10.1016/j.wneu.2019.01.213DOI Listing
February 2019
5 Reads

Epilepsy gene therapy using an engineered potassium channel.

J Neurosci 2019 Feb 12. Epub 2019 Feb 12.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.

Refractory focal epilepsy is a devastating disease for which there is frequently no effective treatment. Gene therapy represents a promising alternative, but treating epilepsy in this way involves irreversible changes to brain tissue, so vector design must be carefully optimized to guarantee safety without compromising efficacy. We set out to develop an epilepsy gene therapy vector optimized for clinical translation. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.1143-18.2019DOI Listing
February 2019
2 Reads

Annexin A1-derived peptide Ac in a pilocarpine-induced status epilepticus model: anti-inflammatory and neuroprotective effects.

J Neuroinflammation 2019 Feb 12;16(1):32. Epub 2019 Feb 12.

Department of Morphology and Genetics, Federal University of São Paulo (UNIFESP), São Paulo, SP, 04023-900, Brazil.

Background: The inflammatory process has been described as a crucial mechanism in the pathophysiology of temporal lobe epilepsy. The anti-inflammatory protein annexin A1 (ANXA1) represents an interesting target in the regulation of neuroinflammation through the inhibition of leukocyte transmigration and the release of proinflammatory mediators. In this study, the role of the ANXA1-derived peptide Ac in an experimental model of status epilepticus (SE) was evaluated. Read More

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http://dx.doi.org/10.1186/s12974-019-1414-7DOI Listing
February 2019
2 Reads

Curcumin reduces development of seizurelike events in the hippocampal-entorhinal cortex slice culture model for epileptogenesis.

Epilepsia 2019 Feb 12. Epub 2019 Feb 12.

Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.

Objective: Inhibition of the mammalian target of rapamycin (mTOR) pathway could be antiepileptogenic in temporal lobe epilepsy (TLE), possibly via anti-inflammatory actions. We studied effects of the mTOR inhibitor rapamycin and the anti-inflammatory compound curcumin-also reported to inhibit the mTOR pathway-on epileptogenesis and inflammation in an in vitro organotypic hippocampal-entorhinal cortex slice culture model.

Methods: Brain slices containing hippocampus and entorhinal cortex were obtained from 6-day-old rat pups and maintained in culture for up to 3 weeks. Read More

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http://dx.doi.org/10.1111/epi.14667DOI Listing
February 2019
1 Read

fMRI prediction of naming change after adult temporal lobe epilepsy surgery: Activation matters.

Epilepsia 2019 Feb 11. Epub 2019 Feb 11.

Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.

Objective: We aimed to predict language deficits after epilepsy surgery. In addition to evaluating surgical factors examined previously, we determined the impact of the extent of functional magnetic resonance imaging (fMRI) activation that was resected on naming ability.

Method: Thirty-five adults (mean age 37. Read More

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http://dx.doi.org/10.1111/epi.14656DOI Listing
February 2019
1 Read

Rapid and specific processing of person-related information in human anterior temporal lobe.

Commun Biol 2019 4;2. Epub 2019 Jan 4.

1Department of Medicine and Surgery, University of Parma, via Volturno 39E, 43125 Parma, Italy.

The anterior temporal lobe (ATL), located at the tip of the human temporal lobes, has been heavily implicated in semantic processing by neuropsychological and functional imaging studies. These techniques have revealed a hemispheric specialization of ATL, but little about the time scale on which it operates. Here we show that ATL is specifically activated in intracerebral recordings when subjects discriminate the gender of an actor presented in a static frame followed by a video. Read More

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http://dx.doi.org/10.1038/s42003-018-0250-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320334PMC
January 2019
1 Read

Ganglion cyst of the temporomandibular joint with intradural extension: case report.

J Neurosurg 2019 Feb 8:1-5. Epub 2019 Feb 8.

4Goodman Campbell Brain and Spine, Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana.

Intracranial extension of temporomandibular joint (TMJ) ganglion cysts is very rare. Two previously reported cases presented clinically due to effects on cranial nerves and had obvious association with the TMJ on imaging. To the authors' knowledge, intracranial extension of a TMJ ganglion cyst presenting with seizures and mimicking a primary brain tumor has not been previously reported. Read More

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http://dx.doi.org/10.3171/2018.10.JNS182665DOI Listing
February 2019
4 Reads

Sustained somatostatin gene expression reverses kindling-induced increases in the number of dividing Type-1 neural stem cells in the hippocampi of behaviorally responsive rats.

Epilepsy Res 2019 Feb 11;150:78-94. Epub 2019 Jan 11.

J. Crayton Pruitt Family Department of Biomedical Engineering, USA; Department of Neuroscience, USA; McKnight Brain Institute, USA. Electronic address:

Neurogenesis persists throughout life in the hippocampi of all mammals, including humans. In the healthy hippocampus, relatively quiescent Type-1 neural stem cells (NSCs) can give rise to more proliferative Type-2a neural progenitor cells (NPCs), which generate neuronal-committed Type-2b NPCs that mature into Type-3 neuroblasts. Many Type-3 neuroblasts survive and mature into functionally integrated granule neurons over several weeks. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.005DOI Listing
February 2019
2 Reads

Machine learning identifies "rsfMRI epilepsy networks" in temporal lobe epilepsy.

Eur Radiol 2019 Feb 8. Epub 2019 Feb 8.

Department of Electrical Engineering, Indian Institute of Technology Delhi, (IIT-D), New Delhi, Delhi, 110016, India.

Objectives: Experimental models have provided compelling evidence for the existence of neural networks in temporal lobe epilepsy (TLE). To identify and validate the possible existence of resting-state "epilepsy networks," we used machine learning methods on resting-state functional magnetic resonance imaging (rsfMRI) data from 42 individuals with TLE.

Methods: Probabilistic independent component analysis (PICA) was applied to rsfMRI data from 132 subjects (42 TLE patients + 90 healthy controls) and 88 independent components (ICs) were obtained following standard procedures. Read More

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http://link.springer.com/10.1007/s00330-019-5997-2
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http://dx.doi.org/10.1007/s00330-019-5997-2DOI Listing
February 2019
10 Reads

Altered upright face recognition and presence of face inversion effect in temporal lobe epilepsy: An event-related potential study.

Psychiatry Clin Neurosci 2019 Feb 7. Epub 2019 Feb 7.

Department of Psychiatry, National Defense Medical College, Japan.

Aim: Facial recognition can be assessed by examining an event-related potential component, namely the N170. The amplitude of the N170 is larger in response to inverted faces than to upright faces. To examine facial processing in patients with temporal lobe epilepsy (TLE), we investigated the amplitude of the N170, the face inversion effect, and the association between social functioning and face-specific configuration processing. Read More

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http://doi.wiley.com/10.1111/pcn.12829
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http://dx.doi.org/10.1111/pcn.12829DOI Listing
February 2019
4 Reads

Psychiatric Assessment in Patients with Mild Temporal Lobe Epilepsy.

Behav Neurol 2019 14;2019:4139404. Epub 2019 Jan 14.

Neurology Unit, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy.

Objectives: The findings of previous studies focused on personality disorders in epileptic patients are difficult to interpret due to nonhomogeneous samples and noncomparable methods. Here, we aimed at studying the personality profile in patients with mild temporal lobe epilepsy (mTLE) with psychiatric comorbidity.

Materials And Methods: Thirty-five patients with mTLE (22 males, mean age 40. Read More

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https://www.hindawi.com/journals/bn/2019/4139404/
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http://dx.doi.org/10.1155/2019/4139404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348858PMC
January 2019
5 Reads

Improved Detection of Subtle Mesial Temporal Sclerosis: Validation of a Commercially Available Software for Automated Segmentation of Hippocampal Volume.

AJNR Am J Neuroradiol 2019 Feb 7. Epub 2019 Feb 7.

Neurosurgery (P.L., R.M.R.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Background And Purpose: Identification of mesial temporal sclerosis is critical in the evaluation of individuals with temporal lobe epilepsy. Our aim was to assess the performance of FDA-approved software measures of hippocampal volume to identify mesial temporal sclerosis in patients with medically refractory temporal lobe epilepsy compared with the initial clinical interpretation of a neuroradiologist.

Materials And Methods: Preoperative MRIs of 75 consecutive patients who underwent a temporal resection for temporal lobe epilepsy from 2011 to 2016 were retrospectively reviewed, and 71 were analyzed using Neuroreader, a commercially available automated segmentation and volumetric analysis package. Read More

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http://dx.doi.org/10.3174/ajnr.A5966DOI Listing
February 2019
1 Read

Medial septal stimulation increases seizure threshold and improves cognition in epileptic rats.

Brain Stimul 2019 Jan 17. Epub 2019 Jan 17.

Department of Neurological Surgery, University of California, Davis, USA; Center for Neuroscience, University of California, Davis, USA. Electronic address:

Background: Temporal lobe epilepsy is most prevalent among focal epilepsies, and nearly one-third of patients are refractory to pharmacological intervention. Persistent cognitive and neurobehavioral comorbidities also occur due to the recurrent nature of seizures and medication-related side effects.

Hypothesis: Electrical neuromodulation is an effective strategy to reduce seizures both in animal models and clinically, but its efficacy to modulate cognition remains unclear. Read More

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http://dx.doi.org/10.1016/j.brs.2019.01.005DOI Listing
January 2019

Electrical cortical stimulation for refractory focal epilepsy: A long-term follow-up study.

Epilepsy Res 2019 Jan 9;151:24-30. Epub 2019 Jan 9.

Section of Epilepsy, Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, Taiwan; Department of Neurology, Xiamen Changgung Hospital, China. Electronic address:

Objective: To report the long-term seizure control and safety of open-loop electrical cortical stimulation in patients with refractory focal epilepsy of diverse etiologies.

Methods: Six patients who received a therapeutic trial of cortical stimulation were included retrospectively. The frequency of seizures was recorded before and after implantation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183049
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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.003DOI Listing
January 2019
8 Reads
2.015 Impact Factor

Effect of Co-administration of Bumetanide and Phenobarbital on Seizure Attacks in Temporal Lobe Epilepsy.

Basic Clin Neurosci 2018 Nov-Dec;9(6):408-416. Epub 2018 Nov 1.

Department of Tissue Engineering & Regenerative Medicine, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.

Introduction: The resistance of temporal lobe epilepsy to classic drugs is thought to be due to disruption in the excitation/inhibition of this pathway. Two chloride transporters, NKCC1 and KCC2, are expressed differently for the excitatory state of Gamma-Amino Butyric Acid (GABA). The present study explored the effect of bumetanide as a selective NKCC1 inhibitor either alone or in combination with the phenobarbital in the pilocarpine model of epilepsy. Read More

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http://bcn.iums.ac.ir/article-1-826-en.html
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http://dx.doi.org/10.32598/bcn.9.6.408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359685PMC
November 2018
2 Reads

Surgical techniques: Stereoelectroencephalography-guided radiofrequency-thermocoagulation (SEEG-guided RF-TC).

Seizure 2019 Jan 25. Epub 2019 Jan 25.

Department of Neurosurgery, Neurology & Neurosurgery Hospital Pierre Wertheimer, Hospices Civils de Lyon, France; University of Lyon, Faculty of medicine Claude Bernard, Lyon, France; NEUROPAIN team, Lyon Neuroscience Research Center, INSERM U1028, CNRS, 5292, Lyon, France.

Stereoelectroencephalography-guided radiofrequency-thermocoagulation (SEEG-guided RF-TC) consists of coupling SEEG investigation with RF-TC stereotactic lesioning directly through the recording electrodes. In this systematic review the surgical technique, indications, and outcomes are described. Maximum accuracy is reached when a frame-based procedure with a robotic assistance and a per-operative vascular X-ray imaging are performed. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.01.021DOI Listing
January 2019
1 Read

The effects of lamotrigine and ethosuximide on seizure frequency, neuronal loss, and astrogliosis in a model of temporal-lobe epilepsy.

Brain Res 2019 Jan 29. Epub 2019 Jan 29.

Neurology department of the First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

Objective: The putative neuroprotective and disease-modifying effects of lamotrigine (LTG) and ethosuximide (ESM) were investigated in the lithium-pilocarpine (Li-Pc) model of temporal-lobe epilepsy (TLE) in rats. Then, spontaneous recurrent seizures (SRS), neuronal loss and astrogliosis were assessed.

Methods: Status Epilepticus (SE) was induced by Li-Pc in five experimental groups: 24 h after SE, all rats received twice daily either a low (10 mg/kg) or high (20 mg/kg) dose of LTG, or a low (25 mg/kg) or high (50 mg/kg) dose of ESM, or solvent. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.01.031DOI Listing
January 2019
3 Reads
2.843 Impact Factor

Adult-onset Rasmussen's Syndrome with associated cortical dysplasia.

Epilepsy Behav Case Rep 2019 28;11:54-57. Epub 2018 Nov 28.

Department of Neurosurgery, UT Health San Antonio, San Antonio, TX, United States of America.

We describe a 23-year-old woman with previous right temporal lobe surgeries for underlying cortical dysplasia, presenting with right hemispheric seizures and epilepsia partialis continua (EPC). After anti-seizure medication adjustments, she developed focal status epilepticus with progressive EEG and neuroimaging changes. Cerebrospinal fluid and serum autoimmune panels were negative except for an elevated serum acetylcholine-receptor antibody titer, but she underwent immunosuppressive therapy. Read More

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http://dx.doi.org/10.1016/j.ebcr.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349012PMC
November 2018
5 Reads

Leukocyte expression profiles reveal gene sets with prognostic value for seizure-free outcome following stereotactic laser amygdalohippocampotomy.

Sci Rep 2019 Jan 31;9(1):1086. Epub 2019 Jan 31.

Division of Neurosurgery, Department of Surgery, University of Arizona College of Medicine, Tucson, AZ, 85724, USA.

Among patients with intractable epilepsy, the most commonly performed surgical procedure is craniotomy for amygdalohippocampectomy (AH). Stereotactic laser amygdalohippocampotomy (SLAH) has also been recently employed as a minimally invasive treatment for intractable temporal lobe epilepsy (TLE). Among patients treated with AH and SLAH approximately 65% and 54% of patients become seizure-free, respectively. Read More

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http://dx.doi.org/10.1038/s41598-018-37763-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355811PMC
January 2019

Seizures and Epilepsy.

Authors:
Emily L Johnson

Med Clin North Am 2019 Mar 3;103(2):309-324. Epub 2018 Dec 3.

Department of Neurology, Johns Hopkins School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA. Electronic address:

Epilepsy affects 65 million people worldwide, and is a leading neurologic cause of loss of quality-adjusted life years. The diagnosis of seizures and epilepsy often depends on a careful history, and is supported with electroencephalogram and imaging. First-line treatment of epilepsy includes medical management. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00257125183012
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http://dx.doi.org/10.1016/j.mcna.2018.10.002DOI Listing
March 2019
14 Reads

Excitotoxicity, neuroinflammation and oxidant stress as molecular bases of epileptogenesis and epilepsy-derived neurodegeneration: The role of vitamin E.

Biochim Biophys Acta Mol Basis Dis 2019 Jan 28. Epub 2019 Jan 28.

Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy. Electronic address:

Glutamate-mediated excitotoxicity, neuroinflammation, and oxidative stress are common underlying events in neurodegeneration. This pathogenic "triad" characterizes the neurobiology of epilepsy, leading to seizure-induced cell death, increased susceptibility to neuronal synchronization and network alterations. Along with other maladaptive changes, these events pave the way to spontaneous recurrent seizures and progressive degeneration of the interested brain areas. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.01.026DOI Listing
January 2019

Commonalities and differences in extracellular levels of hippocampal acetylcholine and amino acid neurotransmitters during status epilepticus and subsequent epileptogenesis in two rat models of temporal lobe epilepsy.

Brain Res 2019 Jan 28. Epub 2019 Jan 28.

Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany; Center for Systems Neuroscience, Hannover, Germany. Electronic address:

Chemically or electrically induced status epilepticus (SE) in rodents is a commonly used method for induction of epilepsy. Structural and functional changes in the hippocampus play a pivotal role in epileptogenesis induced by SE. Although cholinergic mechanisms have long been thought to play an important role in the onset and propagation of epileptic seizures, not much is known about the potential role of acetylcholine (ACh) in ictogenesis and epileptogenesis in SE models of temporal lobe epilepsy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00068993193005
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http://dx.doi.org/10.1016/j.brainres.2019.01.034DOI Listing
January 2019
4 Reads

Acute Seizure Control Efficacy of Multi-site Closed-loop Stimulation in a Temporal Lobe Seizure Model.

IEEE Trans Neural Syst Rehabil Eng 2019 Jan 25. Epub 2019 Jan 25.

Closed-loop electrical stimulation is emerging as a promising neural modulation therapy for refractory epilepsy. However, the efficacy of electrical stimulation is less than optimal and the mechanism of seizure control is still unclear. In this work, we evaluated the acute seizure control efficacy of multi-site closed-loop stimulation (MSCLS) in a rodent model with a custom designed closed-loop neurostimulator. Read More

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http://dx.doi.org/10.1109/TNSRE.2019.2894746DOI Listing
January 2019
1 Read

Over-expression of 5-HT6 Receptor and Activated Jab-1/p-c-Jun Play Important Roles in Pilocarpine-Induced Seizures and Learning-Memory Impairment.

J Mol Neurosci 2019 Jan 29. Epub 2019 Jan 29.

Department of Neurology, Fujian Medical University Union Hospital, Xinquan Road 29#, Fuzhou, 350001, China.

Cognitive impairment is a common comorbidity in patients with temporal lobe epilepsy (TLE) that severely affects patients' quality of life. Also, serotonin 5-hydroxytryptamine 6 (5-HT6) receptor plays an important role in cognition. This study aimed to investigate effects of 5-HT6 receptor on learning-memory capacities in epileptic rats. Read More

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http://link.springer.com/10.1007/s12031-018-1238-4
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http://dx.doi.org/10.1007/s12031-018-1238-4DOI Listing
January 2019
3 Reads

Chorea-Acanthocytosis Presenting as Autosomal Recessive Epilepsy in a Family With a Novel Mutation.

Front Neurol 2018 9;9:1168. Epub 2019 Jan 9.

Department of Neurology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany.

Chorea-acanthocytosis (ChAc) is a rare, adult-onset disease usually characterized by, hence the name, a movement disorder and acanthocytosis in the blood. It is caused by mutations of the gene with an autosomal recessive transmission. We report a consanguineous Turkish family with a different and informative clinical and diagnostic course. Read More

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http://dx.doi.org/10.3389/fneur.2018.01168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334619PMC
January 2019

Hippocampus and Insula Are Targets in Epileptic Patients With Glutamic Acid Decarboxylase Antibodies.

Front Neurol 2018 9;9:1143. Epub 2019 Jan 9.

Epilepsy Unit, Department of Neurology, Hospital Clinic i Provincial, Barcelona, Spain.

Antibodies to glutamic acid decarboxylase (GAD ab) have been found in patients with limbic encephalitis (LE) and chronic pharmacoresistant focal epilepsy (FE). The objectives of the study were to: (1) analyze the clinical and neuroimaging course of patients with FE+GAD ab, (2) compare these characteristics with a control group, and (3) describe the most affected cerebral areas with structural and functional imaging. Patients with FE + high titers of GAD ab and a follow-up of at least 5 years were selected. Read More

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http://dx.doi.org/10.3389/fneur.2018.01143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334555PMC
January 2019
3 Reads

NMDA receptor antibody encephalitis presenting as Transient Epileptic Amnesia.

J Neuroimmunol 2019 Feb 22;327:41-43. Epub 2019 Jan 22.

Cognitive Neurology Research Group, University of Exeter Medical School, Exeter, UK.

Transient Epileptic Amnesia (TEA) is a subtype of temporal lobe epilepsy, typically presenting in a person's early 60s, and of unknown aetiology. Encephalitis caused by antibodies to NMDA receptors (NMDARE) has not previously been documented in TEA. We describe a 47-year-old male who satisfied criteria for TEA, but given his atypical symptoms, was also screened for autoimmune epilepsy. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367595PMC
February 2019

JNK Isoforms Are Involved in the Control of Adult Hippocampal Neurogenesis in Mice, Both in Physiological Conditions and in an Experimental Model of Temporal Lobe Epilepsy.

Mol Neurobiol 2019 Jan 26. Epub 2019 Jan 26.

Departament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.

Neurogenesis in the adult dentate gyrus (DG) of the hippocampus allows the continuous generation of new neurons. This cellular process can be disturbed under specific environmental conditions, such as epileptic seizures; however, the underlying mechanisms responsible for their control remain largely unknown. Although different studies have linked the JNK (c-Jun-N-terminal-kinase) activity with the regulation of cell proliferation and differentiation, the specific function of JNK in controlling adult hippocampal neurogenesis is not well known. Read More

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http://dx.doi.org/10.1007/s12035-019-1476-7DOI Listing
January 2019
4 Reads

Transient seizure onset network for localization of epileptogenic zone: effective connectivity and graph theory-based analyses of ECoG data in temporal lobe epilepsy.

J Neurol 2019 Jan 25. Epub 2019 Jan 25.

Department of Geriatric Medicine, Beijing Luhe Hospital, Capital Medical University, No. 82, Xinhua South Street, Tongzhou District, Beijing, 101149, China.

Objective: Abnormal and dynamic epileptogenic networks cause difficulties for clinical epileptologists in the localization of the seizure onset zone (SOZ) and the epileptogenic zone (EZ) in preoperative assessments of patients with refractory epilepsy. The aim of this study is to investigate the characteristics of time-varying effective connectivity networks in various non-seizure and seizure periods, and to propose a quantitative approach for accurate localization of SOZ and EZ.

Methods: We used electrocorticogram recordings in the temporal lobe and hippocampus from seven patients with temporal lobe epilepsy to characterize the effective connectivity dynamics at a high temporal resolution using the full-frequency adaptive directed transfer function (ffADTF) measure and five graph metrics, i. Read More

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http://link.springer.com/10.1007/s00415-019-09204-4
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http://dx.doi.org/10.1007/s00415-019-09204-4DOI Listing
January 2019
4 Reads

Experience of adverse events with cerebral propofol testing in patients with drug resistant epilepsy.

Sci Rep 2019 Jan 24;9(1):592. Epub 2019 Jan 24.

Department of Neurosurgery, Medical University of Warsaw, Banacha 1a, 02-097, Warsaw, Poland.

The aim of this study was to assess the type and frequency of adverse events during the Wada test conducted with propofol as an anaesthetic agent. In total, 122 patients with temporal lobe epilepsy underwent the Wada test with propofol between 2006 and 2016 as part of presurgical evaluation at the Department of Neurosurgery of the Medical University of Warsaw. The Wada test was conducted bilaterally on 118 patients (236 cases). Read More

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http://dx.doi.org/10.1038/s41598-018-36031-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345790PMC
January 2019
3 Reads

Glia activation of eukaryotic translation initiation factor 4e-binding protein 1 in temporal lobe epilepsy.

Neuroreport 2019 Feb;30(3):222-226

Department of Physical Medicine and Rehabiliation, Qilu Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.

This study was aimed to investigate whether 4e-binding protein 1 is activated during temporal lobe epileptogenesis. We used the hippocampus of patients with refractory temporal lobe epilepsy (TLE), diagnosed with hippocampal sclerosis (HS) or non-HS, to examine the distribution of phospho-4e-binding protein 1 (p4EBP1) by immunohistochemical staining (n=3-5). We also examined p4EBP1 in the kainic acid (KA)-induced mouse model of TLE before and after anticonvulsant treatment (n=3 per group). Read More

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http://dx.doi.org/10.1097/WNR.0000000000001188DOI Listing
February 2019
2 Reads

Ictal asystole with isolated syncope: A case report and literature review.

Epilepsy Behav Case Rep 2019 24;11:47-51. Epub 2018 Nov 24.

Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198-8435, USA.

Ictal syncope is a rare phenomenon that occurs in association with 0.002-0.4% of seizures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22133232183014
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http://dx.doi.org/10.1016/j.ebcr.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327908PMC
November 2018
7 Reads

Role of t-PA and PAI-1 variants in temporal lobe epilepsy in Chinese Han population.

BMC Neurol 2019 Jan 22;19(1):13. Epub 2019 Jan 22.

Department of Pharmacy, Shandong Provincial Hospital affiliated to Shandong University, Jinan, 250100, China.

Background: Epilepsy is one of the most common chronic disabling neurologic diseases. The purpose of our study was to investigate whether there is an association between t-PA (tissue plasminogen activator, rs2020918 and rs4646972), PAI-1 (plasminogen activator inhibitor 1, rs1799768) polymorphisms and susceptibility to temporal lobe epilepsy (TLE) in Chinese Han population.

Method: One hundred and twenty-one cases of patients who were diagnosed as TLE and 146 normal controls were enrolled and the genotypes of t-PA and PAI-1 were detected by polymerase chain reaction-ligase detection reaction (PCR-LDR) method after the genomic DNA being extracted from peripheral blood. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
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http://dx.doi.org/10.1186/s12883-019-1239-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343363PMC
January 2019
7 Reads

Monaural 40-Hz auditory steady-state magnetic responses can be useful for identifying epileptic focus in mesial temporal lobe epilepsy.

Clin Neurophysiol 2019 Mar 28;130(3):341-351. Epub 2018 Dec 28.

Department of Clinical Neurophysiology, Neurological Institute, Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, Japan.

Objective: Patients with mesial temporal lobe epilepsy (mTLE) often exhibit central auditory processing (CAP) dysfunction. Monaural 40-Hz auditory steady-state magnetic responses (ASSRs) were recorded to explore the pathophysiology of mTLE.

Methods: Eighteen left mTLE patients, 11 right mTLE patients and 16 healthy controls (HCs) were examined. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457183140
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http://dx.doi.org/10.1016/j.clinph.2018.11.026DOI Listing
March 2019
5 Reads

What happens to temporal hypometabolism contralateral to side of surgery in patients with bilateral temporal hypometabolism?

Clin Neurol Neurosurg 2019 Mar 17;178:7-12. Epub 2019 Jan 17.

Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey. Electronic address:

Objective: To see what happens on PET hypometabolism on the temporal lobe contralateral to the side of surgery in patients with bitemporal hypometabolism (BTH).

Patients And Methods: This retrospective study with prospectively defined data evaluated the pre- and post-surgical PET hypometabolism on the contralateral temporal lobe after resection of ipsilateral temporal lobe in 10 patients with BTH operated between January, 2010 and May, 2018. On PET we compared standard uptake values (SUV) and relative metabolic activities as compared to normal subjects by means of Z-scores of hypometabolism of unresected temporal lobes before and after surgery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467193001
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http://dx.doi.org/10.1016/j.clineuro.2019.01.008DOI Listing
March 2019
5 Reads

Structural and functional asymmetry of medial temporal subregions in unilateral temporal lobe epilepsy: A 7T MRI study.

Hum Brain Mapp 2019 Jan 21. Epub 2019 Jan 21.

Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania.

Mesial temporal lobe epilepsy (TLE) is a common neurological disorder affecting the hippocampus and surrounding medial temporal lobe (MTL). Although prior studies have analyzed whole-brain network distortions in TLE patients, the functional network architecture of the MTL at the subregion level has not been examined. In this study, we utilized high-resolution 7T T2-weighted magnetic resonance imaging (MRI) and resting-state BOLD-fMRI to characterize volumetric asymmetry and functional network asymmetry of MTL subregions in unilateral medically refractory TLE patients and healthy controls. Read More

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http://doi.wiley.com/10.1002/hbm.24530
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http://dx.doi.org/10.1002/hbm.24530DOI Listing
January 2019
4 Reads

Is additional mesial temporal resection necessary for intractable epilepsy with cavernous malformations in the temporal neocortex?

Epilepsy Behav 2019 Jan 16;92:145-153. Epub 2019 Jan 16.

National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan.

Purpose: Cavernous malformation (CM) in the temporal neocortex causes intractable epilepsy. Whether to resect additional mesial temporal structures in addition to the lesionectomy is a still controversial issue. To clarify the need for the procedure, we retrospectively analyzed pre- and postoperative clinical data of patients with surgically removed CM. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183084
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http://dx.doi.org/10.1016/j.yebeh.2018.12.024DOI Listing
January 2019
9 Reads

Hemispheric Regional Based Analysis of Diffusion Tensor Imaging and Diffusion Tensor Tractography in Patients with Temporal Lobe Epilepsy and Correlation with Patient outcomes.

Sci Rep 2019 Jan 18;9(1):215. Epub 2019 Jan 18.

Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA.

Imaging in the field of epilepsy surgery remains an essential tool in terms of its ability to identify regions where the seizure focus might present as a resectable area. However, in many instances, an obvious structural abnormality is not visualized. This has created the opportunity for new approaches and imaging innovation in the field of epilepsy, such as with Diffusion Tensor Imaging (DTI) and Diffusion Tensor Tractography (DTT). Read More

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http://www.nature.com/articles/s41598-018-36818-x
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http://dx.doi.org/10.1038/s41598-018-36818-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338779PMC
January 2019
8 Reads

The neural response to deep brain stimulation of the anterior nucleus of the thalamus: a MEMRI and c-Fos study.

Brain Res Bull 2019 Jan 15. Epub 2019 Jan 15.

Department of Physiology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil; Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

Background: Deep brain stimulation (DBS) refers to the delivery of electric current to specific deep brain structures through implanted electrodes. Recently approved for use in United States, DBS to the anterior nucleus of thalamus (ANT) is a safe and effective alternative treatment for medically refractory seizures. Despite the anti-seizure effects of ANT DBS, preclinical and clinical studies have failed to demonstrate it actions at a whole brain level. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.011DOI Listing
January 2019
3 Reads

Real-time effects of interictal spikes on hippocampus and amygdala functional connectivity in unilateral temporal lobe epilepsy: An EEG-fMRI study.

Epilepsia 2019 Feb 17;60(2):246-254. Epub 2019 Jan 17.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Objective: To explore the real-time effects of interictal epileptiform discharges (IEDs) on hippocampus and amygdala functional connectivity (FC) in unilateral temporal lobe epilepsy (TLE).

Methods: Patients with unilateral TLE were recruited and underwent simultaneous electroencephalography-functional magnetic resonance imaging (EEG-fMRI) scanning. Simultaneous EEG was used to define the prespike (10 s before spike) and postspike (10 s after spike) periods. Read More

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http://doi.wiley.com/10.1111/epi.14646
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http://dx.doi.org/10.1111/epi.14646DOI Listing
February 2019
7 Reads
4.571 Impact Factor

Preoperative Systemic Inflammatory Markers in Different Brain Pathologies: An Analysis of 140 Patients.

Turk Neurosurg 2018 Oct 14. Epub 2018 Oct 14.

Cerrahpasa Medical Faculty.

Aim: The aim of this study was to analyze preoperative inflammatory markers including neutrophil, lymphocyte and platelet counts and neutrophil to lymphocyte (NLR) and platelet to lymphocyte (PLR) ratios in a group of patients with different brain pathologies and healthy controls.

Material And Methods: Above mentioned preoperative inflammatory markers were analyzed in a total of 140 patients included 39 with temporal lobe epilepsy, 37 with glioblastoma multiforme, 32 with grade-I meningioma and 32 with intracranial metastasis. Healthy controls included 30 subjects. Read More

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http://dx.doi.org/10.5137/1019-5149.JTN.24244-18.2DOI Listing
October 2018
3 Reads

Changing temporal context in human temporal lobe promotes memory of distinct episodes.

Nat Commun 2019 01 14;10(1):203. Epub 2019 Jan 14.

Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.

Memories of experiences that occur around the same time are linked together by a shared temporal context, represented by shared patterns of neural activity. However, shared temporal context may be problematic for selective retrieval of specific memories. Here, we examine intracranial EEG (iEEG) in the human temporal lobe as participants perform a verbal paired associates memory task that requires the encoding of distinct word pairs in memory. Read More

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http://dx.doi.org/10.1038/s41467-018-08189-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331638PMC
January 2019

Nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsy.

Neuroimage Clin 2019 Jan 9:101671. Epub 2019 Jan 9.

Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:

Background And Objectives: We assessed correlations between the resting state functional connectivity (RSFC) of different thalamic nuclei and seizure frequency in patients with drug-resistant medial temporal lobe epilepsy (mTLE).

Methods: Seventeen patients with mTLE and 17 sex-/age-/handedness-matched controls participated. A seed-based correlation method for the resting-state FMRI data was implemented to get RSFC maps of 70 thalamic nuclei seed masks. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101671DOI Listing
January 2019