Search our Database of Scientific Publications and Authors

I’m looking for a

    6762 results match your criteria Temporal Giant Cell Arteritis

    1 OF 136

    Painless Aortic Dissection-Diagnostic Dilemma With Fatal Outcomes: What Do We Learn?
    J Investig Med High Impact Case Rep 2017 Jul-Sep;5(3):2324709617721252. Epub 2017 Jul 31.
    Bassett Medical Center, Cooperstown, NY, USA.
    Aortic dissection is the most catastrophic clinical condition that involves the aorta. It has a high mortality as well as high rate of misdiagnosis due to frequent unusual presentation. Typically, it presents with acute chest, back, and tearing abdominal pain. Read More

    Amalric Triangular Syndrome Associated With Outer Nuclear Layer Infarction.
    Ophthalmic Surg Lasers Imaging Retina 2017 Aug;48(8):668-670
    An 85-year-old man presented with temporal headache and bilateral paracentral scotomas. Clinical examination, laboratory testing, and temporal artery biopsy confirmed the diagnosis of giant cell arteritis. Fluorescein angiography illustrated Amalric triangular choroidal infarction of the left eye. Read More

    Nonarteritic Jaw Claudication.
    J Neuroophthalmol 2017 Sep;37(3):281-284
    Department of Ophthalmology, University of Washington, Seattle, Washington.
    A 60-year-old woman with decreased visual acuity in her right eye and right-sided jaw claudication was found to have ocular ischemic syndrome secondary to complete occlusion of the brachiocephalic artery. Although jaw claudication is often considered to be pathognomonic for giant cell arteritis, it has a broad differential diagnosis including both vascular and nonvascular conditions. Read More

    Myelodysplastic Syndrome and Giant Cell Arteritis: A Nonfortuitous Association that Geriatricians Should Know About.
    J Am Geriatr Soc 2017 Aug 14. Epub 2017 Aug 14.
    Department of Geriatrics, Unit of Peri-Operative Geriatric Care, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France.

    [From pathogenesis of giant cell arteritis to new therapeutic targets].
    Rev Med Interne 2017 Aug 8. Epub 2017 Aug 8.
    Service de médecine interne et immunologie clinique, CHU François-Mitterrand, 2, boulevard Mal-de-Lattre-de-Tassigny, 21000 Dijon, France; Inserm U1098, université Bourgogne-Franche Comté, FHU Increase, 21000 Dijon, France.
    Giant cell arteritis (GCA) is the most common vasculitis in adults. GCA is a granulomatous large-vessel vasculitis involving the aorta and its major branches in people>50 years. Glucocorticoids (GC) remain the cornerstone of GCA treatment. Read More

    Giant Cell Arteritis Presenting as PUO.
    J Assoc Physicians India 2017 Aug;65(8):107-108
    Consultant Physician, Global Hospitals, Chennai, Tamil Nadu.
    Giant cell arteritis(GCA) is a primary granulomatous vasculitis affecting the large and medium sized arteries. We present here a case of GCA with pyrexia of unknown origin (PUO) as the presenting manifestation in the absence of other typical features. On evaluation, the patient had raised inflammatory markers with features of large vessel vasculitis on whole body PET-CT scan. Read More

    A 26-week feasibility study comparing the efficacy and safety of modified-release prednisone with immediate-release prednisolone in newly diagnosed cases of giant cell arteritis.
    Int J Rheum Dis 2017 Aug 9. Epub 2017 Aug 9.
    Department of Rheumatology, Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea, UK.
    Objective: A feasibility study to assess efficacy and safety of modified release (MR) prednisone (Lodotra™) compared to immediate release (IR) prednisolone in patients with newly diagnosed giant cell arteritis (GCA).

    Methods: Twelve patients with new diagnosis of GCA were initially treated with high-dose prednisolone (40-60 mg) daily for 4 weeks and then randomized to two open arms to continue tapering steroid treatment with either standard IR prednisolone or MR prednisone. Patients were reviewed every 2 weeks either face to face or by telephone, for a total of 26 weeks. Read More

    The Association Between Giant Cell Arteritis and Ischemic Heart Disease: A Population Based Cross-Sectional Study.
    Isr Med Assoc J 2017 Jul;19(7):411-414
    Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel.
    Background: Patients with giant cell arteritis (GCA) suffer from inflammatory diseases often treated by large amounts of corticosteroids. Whether this inflammatory burden also carries an increased risk for cardiovascular morbidity, and especially ischemic heart disease, is not clearly established.

    Objectives: To clarify the linkage between GCA and ischemic heart disease. Read More

    Classification of large vessel vasculitis: Can we separate giant cell arteritis from Takayasu arteritis?
    Presse Med 2017 Jul 31. Epub 2017 Jul 31.
    Mayo Clinic College of Medicine, Division of Rheumatology, Rochester, Minnesota, USA.
    The two main variants of large vessel vasculitis include Takayasu arteritis and giant cell arteritis. While these two conditions have historically been considered different conditions, recent evidence questions whether they are a spectrum of the same disease. Classification criteria are limited in distinguishing between cases with phenotypic overlap. Read More

    Polymyalgia rheumatica.
    Lancet 2017 Jul 31. Epub 2017 Jul 31.
    Rheumatology Division, Hospital de La Princesa, Instituto de Investigación Sanitaria-Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
    Polymyalgia rheumatica is an inflammatory disease that affects the shoulder, the pelvic girdles, and the neck, usually in individuals older than 50 years. Increases in acute phase reactants are typical of polymyalgia rheumatica. The disorder might present as an isolated condition or in association with giant cell arteritis. Read More

    Autoimmunity in the Elderly: Insights from Basic Science and Clinics - A Mini-Review.
    Gerontology 2017 Jul 29. Epub 2017 Jul 29.
    Department of Medicine 'B,' Sheba Medical Center, Tel-Hashomer, Israel.
    Advancements in the field of biomedicine, including the control of infectious diseases through antibiotics and vaccination practices and the prevention of chronic disorders, have led to reduced mortality, increased life expectancy and, as such, growth of the older population. Ageing is accompanied by profound morphological and physiological alterations. In particular, the immune system undergoes a complex series of remodeling/restructuring events, involving almost all compartments - both the innate and the adaptive system. Read More

    Diagnostic value of PET/CT for giant cell arteritis combined with pulmonary embolism presenting: Case report and literature review.
    Medicine (Baltimore) 2017 Aug;96(31):e7651
    aDepartment of Rheumatology, China-Japan Friendship Hospital, Beijing bDepartment of Rheumatology, YuLin Traditional Chinese Hospital, YuLin, GuangXi province, China.
    Rationale: Giant cell arteritis (GCA) combined with concomitant pulmonary embolism (PE) is extremely difficult to diagnose because of its low incidence and atypical clinical presentations.

    Patient Concerns: A 62-year-old male developed fever of unknown origin.

    Diagnoses: Positron emission tomography/computed tomography (PET/CT) revealed increased glucose metabolism in the vascular walls of the ascending and descending aorta and pulmonary artery, leading to a diagnosis of GCA combined with PE. Read More

    Investigational drugs in systemic vasculitis.
    Expert Opin Investig Drugs 2017 Sep 4;26(9):1049-1061. Epub 2017 Aug 4.
    a Département Hospitalo-Universitaire Inflammation-Immunopathologie-Biothérapie (DHU i2B) , Sorbonne Universités , UPMC Université Paris 06, UMR 7211 , Paris , France.
    Introduction: Treatment of systemic vasculitis is based on glucocorticoids (GC) in association with immunosuppressive therapy. There are still unmet needs, including earlier onset of response, more targeted therapies, reduction of relapse-risk and decrease of long-term GC and classic immunosuppressants toxicities. Areas covered: In this review, we discuss investigational drugs in early phase clinical trials for induction of remission in vasculitis. Read More

    Varicella Zoster Virus and Large Vessel Vasculitis, the Absence of an Association.
    Pathog Immun 2017 6;2(2):228-238. Epub 2017 Jun 6.
    Center for Vasculitis Care and Research, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, Ohio.
    Objective: It is controversial whether microorganisms play a role in the pathogenesis of large and medium vessel vasculitides (eg, giant cell arteritis [GCA], Takayasu arteritis [TAK] and focal idiopathic aortitis [FIA]). Recent studies have reported the presence of Varicella Zoster Virus (VZV) within formalin-fixed, paraffin-embedded temporal arteries and aortas of about three-quarters or more of patients with these conditions, and in a minority of controls. In a prospective study, we sought to confirm these findings using DNA extracted from vessels that were harvested under surgically aseptic conditions and snap frozen. Read More

    Involvement of Monocyte Subsets in the Immunopathology of Giant Cell Arteritis.
    Sci Rep 2017 Jul 26;7(1):6553. Epub 2017 Jul 26.
    Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
    Monocytes/macrophages are critical in systemic and local inflammation in giant cell arteritis (GCA) and possibly in clinically overlapping polymyalgia rheumatica (PMR). Therefore, we aimed to understand the contribution of monocyte subsets and the CX3CR1-CX3CL1 and CCR2-CCL2 migratory pathways, to the pathology of GCA. Peripheral blood monocytes were enumerated in samples from newly-diagnosed, untreated GCA and PMR patients and after prednisone-induced remission. Read More

    Trial of Tocilizumab in Giant-Cell Arteritis.
    N Engl J Med 2017 07;377(4):317-328
    From the Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston (J.H.S., S.H.U.); Roche Products, Welwyn Garden City (K.T., S.D., N.C.), and Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea (B.D.) - both in the United Kingdom; Genentech, South San Francisco, CA (M.K.); the Department of Rheumatology, Medicine III, University Medical Center and Faculty of Medicine Technische Universität Dresden, Dresden (M.A.), Friedrich-Alexander-University Erlangen-Nürnberg, Department of Internal Medicine 3-Rheumatology and Immunology (J.R.), and Institute of Clinical Immunology (G.S.), Universitätsklinikum Erlangen, Erlangen, and the Division of Rheumatology and Clinical Immunology, Department of Medicine IV, University of Munich, Munich (H.S.-K.) - all in Germany; the Department of General Internal Medicine, University Hospitals Gasthuisberg, Leuven, Belgium (D.B.); the Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center, Groningen, the Netherlands (E.B.); the Department of Autoimmune Diseases, Hospital Clínic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona (M.C.C.); the Division of Internal Medicine, Azienda Ospedaliera-Istituto di Ricovero e Cura a Carattere Scientifico di Reggio Emilia and Università di Modena e Reggio Emilia, Reggio Emilia, Italy (C.S.); and Hospital for Special Surgery, New York (R.S.).
    Background: Giant-cell arteritis commonly relapses when glucocorticoids are tapered, and the prolonged use of glucocorticoids is associated with side effects. The effect of the interleukin-6 receptor alpha inhibitor tocilizumab on the rates of relapse during glucocorticoid tapering was studied in patients with giant-cell arteritis.

    Methods: In this 1-year trial, we randomly assigned 251 patients, in a 2:1:1:1 ratio, to receive subcutaneous tocilizumab (at a dose of 162 mg) weekly or every other week, combined with a 26-week prednisone taper, or placebo combined with a prednisone taper over a period of either 26 weeks or 52 weeks. Read More

    Giant-cell arteritis: concordance study between aortic CT angiography and FDG-PET/CT in detection of large-vessel involvement.
    Eur J Nucl Med Mol Imaging 2017 Jul 24. Epub 2017 Jul 24.
    Department of Internal Medicine, Caen University Hospital, Avenue de la Côte de Nacre, 14000, Caen, France.
    Purpose: The purpose of our study was to assess the concordance of aortic CT angiography (CTA) and FDG-PET/CT in the detection of large-vessel involvement at diagnosis in patients with giant-cell arteritis (GCA).

    Methods: We created a multicenter cohort of patients with GCA diagnosed between 2010 and 2015, and who underwent both FDG-PET/CT and aortic CTA before or in the first ten days following treatment introduction. Eight vascular segments were studied on each procedure. Read More

    Settings and artefacts relevant for Doppler ultrasound in large vessel vasculitis.
    Arthritis Res Ther 2017 Jul 20;19(1):167. Epub 2017 Jul 20.
    Department Radiology, Copenhagen University Hospital. Rigshospitalet, Copenhagen, Denmark.
    Ultrasound is used increasingly for diagnosing large vessel vasculitis (LVV). The application of Doppler in LVV is very different from in arthritic conditions. This paper aims to explain the most important Doppler parameters, including spectral Doppler, and how the settings differ from those used in arthritic conditions and provide recommendations for optimal adjustments. Read More

    The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway.
    Sci Transl Med 2017 Jul;9(399)
    Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
    Microvascular networks in the adventitia of large arteries control access of inflammatory cells to the inner wall layers (media and intima) and thus protect the immune privilege of the aorta and its major branches. In autoimmune vasculitis giant cell arteritis (GCA), CD4 T helper 1 (TH1) and TH17 cells invade into the wall of the aorta and large elastic arteries to form tissue-destructive granulomas. Whether the disease microenvironment provides instructive cues for vasculitogenic T cells is unknown. Read More

    [Large vessel vasculitis : pathogenesis, diagnostic and medical management].
    Rev Med Suisse 2017 Apr;13(557):758-762
    Service d'immunologie et allergologie, Département des spécialités de médecine, HUG, 1211 Genève 14.
    Large vessels vasculitis includes two diseases : 1) giant cell arteritis, formerly known as Horton's arteritis and 2) Takayasu arteritis. In this article, we will describe and compare the epidemiology, pathogenesis, diagnostic criteria and medical management of both vasculitis. T helper (Th) 1 and Th17 responses, genetic links and the role of viral (varicella zoster) and bacterial infection (Mycoplasma pneumoniae or Chlamydia pneumoniae) will be discussed. Read More

    Headache, TIA and subarachnoid haemorrhage: dissecting an unusual cause for stroke-like symptoms.
    BMJ Case Rep 2017 Jul 13;2017. Epub 2017 Jul 13.
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
    We present a case of supraclinoid internal carotid artery dissection. Eleven months prior, the patient developed isolated periorbital pain and was diagnosed with giant-cell arteritis with iritis. The patient experienced recurrent spells concerning for transient ischaemic attacks and was transferred to our institution for endovascular intervention after head CT revealed an embolic infarct with a 'dense middle cerebral artery sign. Read More

    Symptomatic lower-limb giant-cell arteritis: Characteristics, management and long-term outcome.
    J Med Vasc 2017 May 18;42(3):148-156. Epub 2017 Apr 18.
    Vascular Medicine, la Musse, allée Louis-Martin, BP 119, 27180 Saint-Sébastien-de-Morsent, France.
    Objective: To describe characteristics and long-term outcomes of the rare symptomatic lower-limb giant-cell arteritis (LL-GCA).

    Methods: Retrospective analysis of 8 patients (6 women; mean±SD age, 63.6±10. Read More

    [Surgical and endoluminal management of the inflammatory aortitis: A Tunisian center experience].
    J Med Vasc 2017 Jul 2;42(4):213-220. Epub 2017 Jun 2.
    Service de chirurgie cardiovasculaire et thoracique, hôpital Habib Bourguiba, 3029 Sfax, Tunisie.
    Non-infectious aortitis is usually due to giant-cell arteritis, Takayasu disease or Behçet disease. The main aortic lesions are stenoses, occlusions and aneurysms in the Takayasu disease and aneurysms in the Behçet disease and giant-cell arteritis. Treatment is based on corticosteroid therapy and surgery. Read More

    [Anti-IL-6 : new therapeutic trends].
    Rev Med Suisse 2017 Jan;13(544-545):105-109
    Service de rhumatologie, Département de l'appareil locomoteur, CHUV, 1011 Lausanne.
    The anti-IL-6 tocilizumab is a recognized treatment in rheumatoid arthritis and in systemic juvenile idiopathic arthritis. Almost ten years after its first use, there is more information about its security profile and its indication should be extended to other systemic inflammatory diseases, such as the giant cell arteritis. New molecules targetting the IL-6 pathway are under validation : sarilumab, sirukumab and olokizumab. Read More

    An unusual case of aortic rupture after deployment of a bare stent in the treatment of aortic dissection in a patient with giant-cell arteritis.
    Wideochir Inne Tech Maloinwazyjne 2017 Jun 12;12(2):194-198. Epub 2017 May 12.
    Department of Vascular Surgery, Pomeranian Medical University, Szczecin, Poland.
    Giant-cell arteritis is associated with a higher risk of aortic aneurysm and aortic dissection formation. We present a women with aortic dissection type B treated with a stent graft and bare-metal stent implantation. After the stent deployment we noticed aortic rupture, which was successfully treated with implantation of an additional stent graft. Read More

    Giant cell arteritis with polymyalgia rheumatica on FDG-PET/CT.
    Clin Case Rep 2017 Jul 21;5(7):1186-1187. Epub 2017 May 21.
    Department of RheumatologyToho University Medical Center Ohashi HospitalTokyoJapan.
    If there is no pain in the temporal artery, the diagnosis of giant cell arteritis (GCA) may be delayed and blindness may occur. Therefore, FDG-PET/CT is important as a modality for diagnosis of GCA. When GCA is suspected and F-18 FDG-PET/CT is performed, it is worthwhile to pay attention to shoulder and hip joints as polymyalgia rheumatica commonly presents with GCA. Read More

    Visual loss and other cranial ischaemic complications in giant cell arteritis.
    Nat Rev Rheumatol 2017 Aug 6;13(8):476-484. Epub 2017 Jul 6.
    Division of Rheumatology, Azienda Ospedaliera, Istituto di Ricovero e Cura a Carattere Scientifico di Reggio Emilia, Viale Risorgimento 80, 42100 Reggio Emilia, Italy.
    Giant cell arteritis (GCA) is the most common form of vasculitis in individuals aged 50 years and over. GCA typically affects large and medium-sized arteries, with a predilection for the extracranial branches of the carotid artery. Patients with GCA usually present with symptoms and signs that are directly related to the artery that is affected, with or without constitutional manifestations. Read More

    Temporal artery biopsies in south-east Scotland: a five year review.
    J R Coll Physicians Edinb 2017 Jun;47(2):124-128
    S Gajree, 267 Crow Road, Glasgow G117BE UK. Email:
    Temporal artery biopsy is the gold standard investigation for the diagnosis of giant cell arteritis. The aim of this retrospective study was to investigate the use of temporal artery biopsy in diagnosing giant cell arteritis in south-east Scotland over a five-year period. We aimed to quantify success rates, and predictive factors for a positive biopsy, as well as compare the different specialities performing the biopsies. Read More

    Temporal artery biopsy in the diagnosis of giant cell arteritis: Does the end justify the means?
    Ann Med Surg (Lond) 2017 Aug 15;20:1-5. Epub 2017 Jun 15.
    Peninsula Deanery, Torbay Hospital, South Devon Healthcare Trust, Lawes Bridge, Torquay, TQ2 7AA, United Kingdom.
    Background: Early temporal artery biopsy is recommended in all patients with suspected cranial GCA (Giant Cell Arteritis) by the BSR (British Society of Rheumatology) and BHPR (British Health Professionals in Rheumatology) guidelines. This should be performed within one week ideally.

    Aim: To assess ACR (American College of Rheumatology) score at presentation and whether temporal artery biopsy result affects clinical management of the clinically suspected GCA patient. Read More

    Polymyalgia rheumatica and giant cell arteritis-three challenges-consequences of the vasculitis process, osteoporosis, and malignancy: A prospective cohort study protocol.
    Medicine (Baltimore) 2017 Jun;96(26):e7297
    aDepartment of Rheumatology, Odense University Hospital, Svendborg Hospital, Svendborg bFaculty of Health Sciences, University of Southern Denmark cDepartment of Nuclear Medicine, Odense University Hospital, Odense dDepartment of Radiology and Nuclear Medicine, Hospital Southwest Jutland, Esbjerg eCentre of Health Economics Research, University of Southern Denmark fDepartment of Endocrinology gDepartment of Rheumatology, Odense University Hospital, Odense hDiagnostic center, Odense University Hospital, Svendborg Hospital, Svendborg iDepartment of Pathology, Odense University Hospital, Odense jDepartment of Ear Nose Throat Surgery kDepartment of Radiology, Odense University Hospital, Svendborg Hospital, Svendborg lDepartment of Rheumatology, Hospital Southwest Jutland, Esbjerg mPatient Research Partner, Department of Rheumatology, Odense University Hospital, Svendborg Hospital, Svendborg, Denmark.
    Introduction: Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are common inflammatory conditions. The diagnosis of PMR/GCA poses many challenges since there are no specific diagnostic tests. Recent literature emphasizes the ability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to assess global disease activity in inflammatory diseases. Read More

    Diagnostic delay for giant cell arteritis - a systematic review and meta-analysis.
    BMC Med 2017 Jun 28;15(1):120. Epub 2017 Jun 28.
    Research Institute for Primary Care and Health Sciences, Keele University, ST5 5BG, Newcastle, UK.
    Background: Giant cell arteritis (GCA), if untreated, can lead to blindness and stroke. The study's objectives were to (1) determine a new evidence-based benchmark of the extent of diagnostic delay for GCA and (2) examine the role of GCA-specific characteristics on diagnostic delay.

    Methods: Medical literature databases were searched from inception to November 2015. Read More

    [Polymyalgia rheumatica: diagnostic and therapeutic issues of an apparently straightforward disease.]
    Recenti Prog Med 2017 May;108(5):221-231
    SC Reumatologia, Dipartimento Apparato Locomotore, ASL3 "Genovese" - Laboratorio di Autoimmunologia, Dipartimento di Medicina Interna (DiMI), Università di Genova.
    Polymyalgia rheumatica (PMR) is an inflammatory disease characterized by aching and stiffness in the girdles, which affects typically people over 50 years old and could overlap with giant cell arteritis (GCA) in about 15-20% of cases. Although the diagnosis of PMR is usually considered straightforward, clinicians facing this disease should be aware of its atypical manifestations, which can hamper the correct identification of PMR and, conversely, should be aware of other diseases which may present with polymyalgic features. The aim of this review is to synthetize current knowledge about clinical presentations of PMR, the differential diagnoses, the relationship with cancer, the clues to the presence of a concomitant GCA, the role of ultrasonography at the onset and in the follow-up and, finally, treatment approaches. Read More

    [Large vessel vasculitis : Giant cell arteritis and Takayasu arteritis].
    Z Rheumatol 2017 Jun 21. Epub 2017 Jun 21.
    Universitätsklinik für Rheumatologie, Immunologie und Allergologie, Inselspital und Universität, 3010, Bern, Schweiz.
    According to the Chapel Hill Classification, large vessel vasculitides encompass giant cell arteritis (GCA) and the histologically related Takakaysu arteritis (TAK). The two diseases lack autoantibodies and present with a systemic inflammatory response. GCA typically shows a sudden onset with profound sickness, loss of appetite and of body weight, and temporal headache. Read More

    Giant cell arteritis, polymyalgia rheumatica, and late-onset rheumatoid arthritis: Can they be components of a single disease process in elderly patients?
    Eur J Rheumatol 2017 Jun 24;4(2):157-160. Epub 2017 Feb 24.
    Department of Internal Medicine, Eskişehir Osmangazi University School of Medicine, Eskişehir, Turkey.
    Objective: To report two patients with giant cell arteritis (GCA) who developed rheumatoid arthritis (RA) and to review the literature in terms of coexistence of RA, GCA, and polymyalgia rheumatica (PMR).

    Methods: We conducted a comprehensive review of the English literature from 1980 to 2015 to analyze data on the coexistence of GCA and RA. The PubMed, Web of Science, Proquest, and Ovid databases were searched for articles using the term RA combined with temporal arteritis, GCA, and PMR. Read More

    A Rare Case of Paraneoplastic Aortitis Associated with Chronic Myelomonocytic Leukemia.
    Case Rep Hematol 2017 25;2017:3091973. Epub 2017 May 25.
    Division of Rheumatology, Cooper University Hospital, Camden, NJ, USA.
    Aortitis is a broad term describing inflammation of the aorta. The most common causes of aortitis are the large-vessel vasculitides giant cell arteritis and Takayasu arteritis. Other etiologies include aortitis associated with other autoimmune disorders, infectious causes, and paraneoplastic and idiopathic cases. Read More

    Association between giant cell arteritis and thyroid dysfunction in a "real life" population.
    Endocrine 2017 Aug 16;57(2):241-246. Epub 2017 Jun 16.
    Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.
    Purpose: Giant cell arteritis is a systemic autoimmune disorder which involves inflammation of medium to large vessels. The association between giant cell arteritis and autoimmune thyroid disorders has been investigated numerous times in the literature with inconsistent results. Our objective was to evaluate whether a genuine association exists between giant cell arteritis and thyroid dysfunction, which is often due to immune-mediated thyroid disease. Read More

    Thick corneas, large pupils, and a giant problem.
    Surv Ophthalmol 2017 Jun 13. Epub 2017 Jun 13.
    Baylor College of Medicine, Houston, Texas, USA.
    An 87-year-old woman presented 1 month after uneventful cataract surgery with ipsilateral corneal edema. She was diagnosed with pseudophakic bullous keratopathy and scheduled for endothelial transplantation. A few days later, however, she presented with bilateral corneal edema, dilated pupils, and further reduction of visual acuity. Read More

    Is Routine Imaging of the Aorta Warranted in Patients With Giant Cell Arteritis?
    J Neuroophthalmol 2017 Sep;37(3):314-319
    Department of Ophthalmology and Neurology (JJC), Mayo Clinic, Rochester, Minnesota; Division of Rheumatology (KW), Mayo Clinic, Rochester, Minnesota; Department of Ophthalmology (JG), Mayo Clinic, Rochester, Minnesota; and Division of Neuro-Ophthalmology, Department of Neurology, Brigham and Women's Hospital (SP), Harvard Medical School, Boston, Massachusetts.

    [Granulomatous reaction pattern of the skin : Interstitial granulomatous dermatitis - lymphoma - vasculitis].
    Hautarzt 2017 Jul;68(7):553-559
    Konsultations- und Referenzzentrum für Vaskulitis-Diagnostik, MVZ am Marienkrankenhaus gGmbH, Hamburg, Deutschland.
    A particular diagnostic situation in the classification of a granulomatous dermatitis results when no circumscribed granulomas but instead a diffuse interstitial histiocytic inflammatory infiltrate, a granulomatous vasculitis or a neoplastic lymphocytic infiltrate is found. Interstitial granulomatous dermatitis was originally described in patients with arthritis. Later, it was recognized that there are also associations with other usually immunological diseases. Read More

    Endothelin-1 promotes vascular smooth muscle cell migration across the artery wall: a mechanism contributing to vascular remodelling and intimal hyperplasia in giant-cell arteritis.
    Ann Rheum Dis 2017 Sep 12;76(9):1624-1634. Epub 2017 Jun 12.
    Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CRB-CELLEX, Barcelona, Spain.
    Background: Giant-cell arteritis (GCA) is an inflammatory disease of large/medium-sized arteries, frequently involving the temporal arteries (TA). Inflammation-induced vascular remodelling leads to vaso-occlusive events. Circulating endothelin-1 (ET-1) is increased in patients with GCA with ischaemic complications suggesting a role for ET-1 in vascular occlusion beyond its vasoactive function. Read More

    Eosinophilic angiitis presenting with a true, fusiform, temporal artery aneurysm.
    Clin Case Rep 2017 Jun 8;5(6):769-773. Epub 2017 Apr 8.
    Department of RheumatologyQueen Elizabeth Hospital BirminghamMendelsohn Way, EdgbastonBirminghamB15 2THUK.
    Temporal artery aneurysm is a rare cause of temporal artery swelling in the absence of preceding trauma. Vasculitis other than giant cell arteritis, such as eosinophilic granulomatosis with polyangiitis, should be considered in such cases and a careful assessment of other medium-sized arteries undertaken. Read More

    1 OF 136