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    1 OF 135

    [Polymyalgia rheumatica: diagnostic and therapeutic issues of an apparently straightforward disease.]
    Recenti Prog Med 2017 May;108(5):221-231
    SC Reumatologia, Dipartimento Apparato Locomotore, ASL3 "Genovese" - Laboratorio di Autoimmunologia, Dipartimento di Medicina Interna (DiMI), Università di Genova.
    Polymyalgia rheumatica (PMR) is an inflammatory disease characterized by aching and stiffness in the girdles, which affects typically people over 50 years old and could overlap with giant cell arteritis (GCA) in about 15-20% of cases. Although the diagnosis of PMR is usually considered straightforward, clinicians facing this disease should be aware of its atypical manifestations, which can hamper the correct identification of PMR and, conversely, should be aware of other diseases which may present with polymyalgic features. The aim of this review is to synthetize current knowledge about clinical presentations of PMR, the differential diagnoses, the relationship with cancer, the clues to the presence of a concomitant GCA, the role of ultrasonography at the onset and in the follow-up and, finally, treatment approaches. Read More

    [Large vessel vasculitis : Giant cell arteritis and Takayasu arteritis].
    Z Rheumatol 2017 Jun 21. Epub 2017 Jun 21.
    Universitätsklinik für Rheumatologie, Immunologie und Allergologie, Inselspital und Universität, 3010, Bern, Schweiz.
    According to the Chapel Hill Classification, large vessel vasculitides encompass giant cell arteritis (GCA) and the histologically related Takakaysu arteritis (TAK). The two diseases lack autoantibodies and present with a systemic inflammatory response. GCA typically shows a sudden onset with profound sickness, loss of appetite and of body weight, and temporal headache. Read More

    Giant cell arteritis, polymyalgia rheumatica, and late-onset rheumatoid arthritis: Can they be components of a single disease process in elderly patients?
    Eur J Rheumatol 2017 Jun 24;4(2):157-160. Epub 2017 Feb 24.
    Department of Internal Medicine, Eskişehir Osmangazi University School of Medicine, Eskişehir, Turkey.
    Objective: To report two patients with giant cell arteritis (GCA) who developed rheumatoid arthritis (RA) and to review the literature in terms of coexistence of RA, GCA, and polymyalgia rheumatica (PMR).

    Methods: We conducted a comprehensive review of the English literature from 1980 to 2015 to analyze data on the coexistence of GCA and RA. The PubMed, Web of Science, Proquest, and Ovid databases were searched for articles using the term RA combined with temporal arteritis, GCA, and PMR. Read More

    A Rare Case of Paraneoplastic Aortitis Associated with Chronic Myelomonocytic Leukemia.
    Case Rep Hematol 2017 25;2017:3091973. Epub 2017 May 25.
    Division of Rheumatology, Cooper University Hospital, Camden, NJ, USA.
    Aortitis is a broad term describing inflammation of the aorta. The most common causes of aortitis are the large-vessel vasculitides giant cell arteritis and Takayasu arteritis. Other etiologies include aortitis associated with other autoimmune disorders, infectious causes, and paraneoplastic and idiopathic cases. Read More

    Association between giant cell arteritis and thyroid dysfunction in a "real life" population.
    Endocrine 2017 Jun 16. Epub 2017 Jun 16.
    Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.
    Purpose: Giant cell arteritis is a systemic autoimmune disorder which involves inflammation of medium to large vessels. The association between giant cell arteritis and autoimmune thyroid disorders has been investigated numerous times in the literature with inconsistent results. Our objective was to evaluate whether a genuine association exists between giant cell arteritis and thyroid dysfunction, which is often due to immune-mediated thyroid disease. Read More

    Thick corneas, large pupils, and a giant problem.
    Surv Ophthalmol 2017 Jun 13. Epub 2017 Jun 13.
    Baylor College of Medicine, Houston, Texas, United States of America.
    An 87-year-old woman presented 1 month after uneventful cataract surgery with ipsilateral corneal edema. She was diagnosed with pseudophakic bullous keratopathy and scheduled for endothelial transplantation. However, a few days later, she presented with bilateral corneal edema, dilated pupils and further reduction of visual acuity. Read More

    Is Routine Imaging of the Aorta Warranted in Patients With Giant Cell Arteritis?
    J Neuroophthalmol 2017 Jun 13. Epub 2017 Jun 13.
    Department of Ophthalmology and Neurology (JJC), Mayo Clinic, Rochester, Minnesota; Division of Rheumatology (KW), Mayo Clinic, Rochester, Minnesota; Department of Ophthalmology (JG), Mayo Clinic, Rochester, Minnesota; and Division of Neuro-Ophthalmology, Department of Neurology, Brigham and Women's Hospital (SP), Harvard Medical School, Boston, Massachusetts.

    [Granulomatous reaction pattern of the skin : Interstitial granulomatous dermatitis - lymphoma - vasculitis].
    Hautarzt 2017 Jun 12. Epub 2017 Jun 12.
    Konsultations- und Referenzzentrum für Vaskulitis-Diagnostik, MVZ am Marienkrankenhaus gGmbH, Hamburg, Deutschland.
    A particular diagnostic situation in the classification of a granulomatous dermatitis results when no circumscribed granulomas but instead a diffuse interstitial histiocytic inflammatory infiltrate, a granulomatous vasculitis or a neoplastic lymphocytic infiltrate is found. Interstitial granulomatous dermatitis was originally described in patients with arthritis. Later, it was recognized that there are also associations with other usually immunological diseases. Read More

    Endothelin-1 promotes vascular smooth muscle cell migration across the artery wall: a mechanism contributing to vascular remodelling and intimal hyperplasia in giant-cell arteritis.
    Ann Rheum Dis 2017 Jun 12. Epub 2017 Jun 12.
    Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CRB-CELLEX, Barcelona, Spain.
    Background: Giant-cell arteritis (GCA) is an inflammatory disease of large/medium-sized arteries, frequently involving the temporal arteries (TA). Inflammation-induced vascular remodelling leads to vaso-occlusive events. Circulating endothelin-1 (ET-1) is increased in patients with GCA with ischaemic complications suggesting a role for ET-1 in vascular occlusion beyond its vasoactive function. Read More

    Eosinophilic angiitis presenting with a true, fusiform, temporal artery aneurysm.
    Clin Case Rep 2017 Jun 8;5(6):769-773. Epub 2017 Apr 8.
    Department of RheumatologyQueen Elizabeth Hospital BirminghamMendelsohn Way, EdgbastonBirminghamB15 2THUK.
    Temporal artery aneurysm is a rare cause of temporal artery swelling in the absence of preceding trauma. Vasculitis other than giant cell arteritis, such as eosinophilic granulomatosis with polyangiitis, should be considered in such cases and a careful assessment of other medium-sized arteries undertaken. Read More

    Gillies temporal incision: an alternate approach to superficial temporal artery biopsy.
    Br J Oral Maxillofac Surg 2017 May 29. Epub 2017 May 29.
    Dept. of Oral & Maxillofacial Surgery, Pennine Acute NHS Trust. Electronic address:
    The main complications of a biopsy of the superficial temporal artery using a standard preauricular approach include scars on the face, weakness of the temporal branch of the facial nerve, and the possible harvest of a disease-free segment of artery. We describe a modification of the Gillies temporal approach, which when placed at the junction of the frontal and parietal branch can be easily modified to harvest either branch. It avoids scarring to the face as it is hidden within the hairline. Read More

    Recent advances in our understanding of giant cell arteritis pathogenesis.
    Autoimmun Rev 2017 May 28. Epub 2017 May 28.
    Department of Internal Medicine and Clinical Immunology, François Mitterrand Hospital, Dijon University Hospital, Dijon, France; INSERM, UMR1098, University of Bourgogne Franche-Comté, FHU INCREASE, Dijon, France.
    Giant cell arteritis (GCA) is a granulomatous vasculitis affecting large arteries, especially the aorta and the extracranial branches of the external carotid artery. Its exact pathogenesis is not fully understood but major progress has been made in recent years, leading to new therapeutic targets like inhibition of the interleukin-6 pathway or the modulation of immune checkpoints. The cause of GCA has not been clearly identified but it is thought that GCA occurs on a genetic background and is triggered by unknown environmental factors that could activate and lead to the maturation of dendritic cells localized in the adventitia of normal arteries. Read More

    Cutaneous nocardiosis manifesting as a frontal mass in a patient with giant cell arteritis.
    Clujul Med 2017 25;90(2):231-234. Epub 2017 Apr 25.
    Rheumatology Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
    We report the case of a subcutaneous abscess due to Nocardia spp. mimicking a spontaneous hematoma or an aneurysm of the temporal artery branch, in a giant cell arteritis patient treated with methylprednisolone and azathioprine. Ultrasonography, incision and drainage with cultures helped in the diagnosis. Read More

    Autoimmunity in 2016.
    Clin Rev Allergy Immunol 2017 May 30. Epub 2017 May 30.
    Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, via A. Manzoni 56, 20089, Rozzano, Milan, Italy.
    The number of peer-reviewed articles published during the 2016 solar year and retrieved using the "autoimmunity" key word remained stable while gaining a minimal edge among the immunology articles. Nonetheless, the quality of the publications has been rising significantly and, importantly, acquisitions have become available through scientific journals dedicated to immunology or autoimmunity. Major discoveries have been made in the fields of systemic lupus erythematosus, rheumatoid arthritis, autoimmunity of the central nervous system, vasculitis, and seronegative spondyloarthrithritides. Read More

    Contemporary prevalence estimates for giant cell arteritis and polymyalgia rheumatica, 2015.
    Semin Arthritis Rheum 2017 Apr 7. Epub 2017 Apr 7.
    Department of Internal Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN; Division of Epidemiology, Department of Health Science Research, Mayo Clinic College of Medicine and Science, Rochester, MN. Electronic address:
    Objective: There are no estimates of the prevalence of giant cell arteritis (GCA) or polymyalgia rheumatica (PMR) in a US population in the current millennium. The purpose of this study was to estimate the 2015 prevalence of GCA and PMR in a US population-based setting.

    Methods: Cohorts of incident GCA in 1950-2009 and incident PMR in 1970-2014 were previously identified among residents of Olmsted County, Minnesota. Read More

    Cutaneous Manifestations of Medium- and Large-Vessel Vasculitis.
    Clin Rev Allergy Immunol 2017 May 26. Epub 2017 May 26.
    Université Pierre et Marie Curie-Paris VI, Assistance Publique-Hôpitaux de Paris, Service de Dermatologie-Allergologie, Hôpital Tenon, 4 rue de la Chine, 75020, Paris, France.
    Dermatologic manifestations are observed in almost all systemic vasculitides, even in large-and medium-vessel vasculitides, although such vessels are not found in the skin. Cutaneous manifestations may be related to a direct skin localization of the systemic vasculitis or a non-specific process associated with the vasculitis. According to the 2012 International Chapel Hill consensus, the two major variants of large-vessel vasculitides are Takayasu arteritis and giant-cell arteritis. Read More

    Multiple Cranial Nerve Palsies in Giant Cell Arteritis.
    J Neuroophthalmol 2017 May 18. Epub 2017 May 18.
    Department of Ophthalmology (MR), McGill University, McGill Academic Eye Centre, Montreal, Quebec, Canada; Department of Ophthalmology (LB), Ivey Eye Institute, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; and Department of Ophthalmology (RS, MG), McGill University Montreal, Quebec, Canada.
    Giant cell arteritis (GCA) is a systemic vasculitis of medium and large arteries often with ophthalmic involvement, including ischemic optic neuropathy, retinal artery occlusion, and ocular motor cranial nerve palsies. This last complication occurs in 2%-15% of patients, but typically involves only 1 cranial nerve. We present 2 patients with biopsy-proven GCA associated with multiple cranial nerve palsies. Read More

    Cerebrovascular events are associated with lower survival in giant cell arteritis: a case-controlled multicenter study.
    Joint Bone Spine 2017 May 19. Epub 2017 May 19.
    Service de Médecine 2, Institut e3m, Centre National de Référence Maladies Systémiques Rares, Lupus systémique et Syndrome des Anticorps Antiphospholipides, Assistance Publique-Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, 75013, Paris, France; Université Paris VI Pierre et Marie Curie, Sorbonnes Universités, 75013, Paris, France. Electronic address:

    Giant cell arteritis with arteritic anterior ischemic optic neuropathy.
    Rom J Morphol Embryol 2017 ;58(1):281-285
    Department of Neurology, "Victor Babes" University of Medicine and Pharmacy, First Department of Neurology, Emergency County Hospital, Timisoara, Romania;
    Giant cell arteritis (GCA) is an inflammatory vasculitis of unknown etiology that mainly involves large and medium arteries, particularly the cranial branches of the aorta. GCA with consecutive arteritic-anterior ischemic optic neuropathy (A-AION) has rarely been diagnosed in Romania. Recently, we encountered an 83-year-old patient who presented with left eye visual impairment and corresponding optic disc diffusely swollen and pale. Read More

    (18)F-FDG PET/CT in polymyalgia rheumatica-a pictorial review.
    Br J Radiol 2017 Jun 16:20170198. Epub 2017 Jun 16.
    8 Rheumatology Unit, 2nd Department of Internal Medicine, St Anne's University Hospital Brno and Masaryk University, Brno, Czech Republic.
    Polymyalgia rheumatica (PMR) is one of the inflammatory rheumatic diseases that can potentially be detected by positron emission tomography/CT. High fluorine-18 fludeoxyglucose ((18)F-FDG) accumulation around the shoulders, sternoclavicular and hip joints are the most common pre-treatment features of patients with PMR. Another common sign is increased (18)F-FDG uptake in extra-articular regions between columnal spinous processes, near ischial tuberosities and in the praepubic area. Read More

    The value of ultrasound in diagnosing extracranial large-vessel vasculitis compared to FDG-PET/CT: A retrospective study.
    Clin Rheumatol 2017 May 15. Epub 2017 May 15.
    Department of Rheumatology, Nephrology, Oncology, Klinikum Ludwigshafen, Bremserstr. 79, D-67065, Ludwigshafen, Germany.
    Large-vessel vasculitis (LVV) is a group of diseases mainly comprised of giant-cell arteritis (GCA), Takayasu arteritis, and a series of rare diseases like Behçet's disease, IgG4-related disease, infectious aortitis, and other unfrequent entities. Besides clinical and laboratory features, Doppler sonography (DS) can assist in establishing the diagnosis. Its diagnostic sensitivity has been evaluated in various studies, most of them, however, in temporal arteritis (TA) respectively in LVV with involvement of the temporal artery. Read More

    A cohort study reveals myocarditis to be a rare and life-threatening presentation of large vessel vasculitis.
    Semin Arthritis Rheum 2017 Apr 4. Epub 2017 Apr 4.
    Rheumatology Department, Imperial College Healthcare NHS Trust and Imperial College London, Hammersmith Hospital, London, UK.
    Background: The predominant forms of adult large vessel vasculitis (LVV) are giant cell arteritis (GCA) and Takayasu arteritis (TA). Cardiac involvement in LVV is a cause of morbidity and mortality, particularly in TA. Cardiac failure is most commonly secondary to uncontrolled arterial hypertension or myocardial ischaemia. Read More

    Clinically isolated aortitis: pitfalls, progress, and possibilities.
    Cardiovasc Pathol 2017 Apr 23;29:23-32. Epub 2017 Apr 23.
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:
    Non-infectious aortitis may be caused by several distinct systemic rheumatologic diseases. In some patients, aortitis is identified either pathologically or radiologically in the absence of clinical evidence of a systemic vasculitis. By consensus nomenclature, such cases are referred to as clinically isolated aortitis (CIA). Read More

    Tocilizumab for giant cell arteritis with corticosteroid-resistant progressive anterior ischemic optic neuropathy.
    Joint Bone Spine 2017 May 9. Epub 2017 May 9.
    Service of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.
    Background: Giant cell arteritis is an inflammatory disorder of the medium- and large-size arteries. Permanent visual loss related to arteritic anterior ischemic optic neuropathy is among the most serious complications of this disease and initial treatment usually consists of high dose corticosteroids. There is no consensus in the literature concerning the optimal therapeutic approach in giant cell arteritis patients with corticosteroid-resistant arteritic anterior ischemic optic neuropathy. Read More

    Takayasu's Arteritis Presenting with Headache and Peripheral Facial Palsy: A Case Report.
    J Tehran Heart Cent 2016 Oct;11(4):195-197
    Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
    Takayasu's arteritis (TA) is a rare case of granulomatous arteritis which mainly involves the aorta and its large branches. Although arterial hypertension is the most common feature of the disease in both adults and children, patients with TA may present with numerous clinical manifestations. Our patient was a 45-year-old woman, known to have hypertension from 3 years earlier following assessments made for severe headache. Read More

    The Central Bright Spot Sign: A Potential New MR Imaging Sign for the Early Diagnosis of Anterior Ischemic Optic Neuropathy due to Giant Cell Arteritis.
    AJNR Am J Neuroradiol 2017 May 11. Epub 2017 May 11.
    From the Department of Neuroradiology and MRI (P.R., A.A., A.K.), SFR RMN Neurosciences, and Department of Ophthalmology (P.R., F.A., C.C.), University Hospital of Grenoble, Grenoble, France; University Grenoble Alpes (A.A., L.L., N.B., A.K.), IRMaGe, Grenoble, France; and Department of Neuroradiology (A.L.), Rothschild Foundation, Paris, France.
    Background And Purpose: A rapid identification of the etiology of anterior ischemic optic neuropathy is crucial because it determines therapeutic management. Our aim was to assess MR imaging to study the optic nerve head in patients referred with anterior ischemic optic neuropathy, due to either giant cell arteritis or the nonarteritic form of the disease, compared with healthy subjects.

    Materials And Methods: Fifteen patients with giant cell arteritis-related anterior ischemic optic neuropathy and 15 patients with nonarteritic anterior ischemic optic neuropathy from 2 medical centers were prospectively included in our study between August 2015 and May 2016. Read More

    Update on the management of giant cell arteritis.
    Ther Adv Chronic Dis 2017 Apr 28;8(4-5):69-79. Epub 2017 Mar 28.
    Division of Rheumatology, Department of Medicine, University of Alberta, 8-130K Clinical Sciences Building, Edmonton, AB, T6G 2G3, Canada.
    Giant cell arteritis (GCA) is a large vessel vasculitis that may be associated with significant complications such as blindness, stroke, or aortic aneurysm and dissection in a subset of patients. Given the serious side effects associated with prolonged courses of glucocorticoids and frequent relapses experienced when doses are tapered, increased efforts are being dedicated to the discovery of safer and more effective therapies to control this disease. The purpose of this review is to critically evaluate the role of glucocorticoid-sparing agents in the medical management of GCA with a special focus on the most recent evidence regarding the role of biologic agents, including tocilizumab (TCZ), abatacept and ustekinumab, and other novel therapies. Read More

    [Choosing wisely recommendations in rheumatology : One year after their first publication].
    Internist (Berl) 2017 Jun;58(6):580-584
    Deutsche Gesellschaft für Rheumatologie (DGRh), Berlin, Deutschland.
    Almost 1 year after publication of the Choosing wisely recommendations ("Klug-entscheiden-Empfehlungen," KEE) for rheumatology, it is evident that they have found their way into specialist and lay publications, the media used by self-help groups, online media, and continuing education congresses. As such, a broad target audience has been reached. In the meantime, newly established or updated guidelines have been published which incorporate the KEE for rheumatology. Read More

    Giant Cell Arteritis - Beyond temporal artery biopsy and steroids.
    Intern Med J 2017 May 9. Epub 2017 May 9.
    Rheumatology Unit, The Queen Elizabeth Hospital, Woodville, South Australia, Australia.
    Giant cell arteritis is the commonest primary vasculitis of the elderly. The acute complications of untreated Giant cell arteritis such as vision loss or occasionally stroke can be devastating. The diagnosis is however not altogether straightforward due to variable sensitivities of the temporal artery biopsy as a reference diagnostic test. Read More

    [Bilateral papilledema].
    J Fr Ophtalmol 2017 May 6;40(5):422-429. Epub 2017 May 6.
    Service d'ophtalmologie, CHU de Bordeaux, place Amelie-Raba-Léon, 33000 Bordeaux, France; Inserm, U1219, Bordeaux Population Health Research Center, 33000 Bordeaux, France. Electronic address:
    This article will review the current standard of care in the diagnosis and management of bilateral optic disc edema. Two emergent conditions must be considered first: secondary intracranial hypertension (cerebral tumor, cerebral thrombophlebitis…) and arteritic ischemic optic neuropathy (or giant cell arteritis). Having ruled out these two diagnoses, the management follows various steps in order to: (i) rule out pseudo-edema, and (ii) determine the underlying cause of the edema: papilledema, non-arteritic ischemic optic neuropathy or papillitis. Read More

    New insights into the pathogenesis of giant cell arteritis.
    Autoimmun Rev 2017 Jul 4;16(7):675-683. Epub 2017 May 4.
    Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Reumatologia, Università degli Studi di Palermo, Palermo, Italy. Electronic address:
    Giant cell arteritis (GCA) is an inflammatory chronic disease occurring exclusively in elderly individuals. Until recently, the disease has been considered a unique disease resulting from the interaction in the walls of susceptible arteries, between an unknown infectious agents with local dendritic cells (DCs), activated CD4 T cells and effector macrophages. Recent evidence has shown that this view was too simplistic and has clarified many of the pathogenetic aspects of the disease. Read More

    IgG, kappa monoclonal gammopathy of unknown significance with AL amyloidosis simulating giant cell arteritis.
    Rom J Intern Med 2017 May 3. Epub 2017 May 3.
    Medicine Clinic, Colentina Hospital, Bucharest.
    Monoclonal gammopathies complicated by AL amyloidosis can mimic giant cell arteritis (GCA).We hereby present the case of a 63 year old woman in whom symptoms consistent with GCA were the first manifestations of a monoclonal gammopathy of unknown significance (MGUS) associated with amyloidosis. A 63 year old woman was admitted for temporal headache, maseterine claudication, neck and shoulder stiffness. Read More

    Interleukin-6 and soluble interleukin-6 receptor are elevated in large-vessel vasculitis: a cross-sectional and longitudinal study.
    Clin Exp Rheumatol 2017 Mar-Apr;35 Suppl 103(1):102-110. Epub 2017 Apr 20.
    Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy.
    Objectives: To investigate serum levels of IL- 6 and soluble IL-6 receptor (sIL-6R) in patients with large-vessel vasculitis and their relationship with disease activity.

    Methods: Sera were obtained from 33 Takayasu's arteritis (TAK) patients and 14 giant cell arteritis (GCA) patients, and from 60 age-matched normal controls (NCs). Disease activity was assessed using 18F-FDG PET/CT and clinical indices including NIH/Kerr criteria and ITAS. Read More

    Risk factors for severe cranial ischaemic events in patients with giant cell arteritis.
    Clin Exp Rheumatol 2017 Mar-Apr;35 Suppl 103(1):88-93. Epub 2017 Apr 19.
    Department of Internal Medicine D and Rheumatology Unit, The Chaim Sheba Medical Center, Tel-Hashomer, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Israel.
    Objectives: Cranial ischaemic events constitute a significant component in the clinical spectrum of giant cell arteritis (GCA). Our aim was to investigate whether cardiovascular risk factors, specific medications and baseline clinical features are associated with the development of severe cranial ischaemic events in GCA patients.

    Methods: Retrospective analysis of GCA patients. Read More

    Poor Predictive Value of Isolated Adventitial and Periadventitial Infiltrates in Temporal Artery Biopsies for Diagnosis of Giant Cell Arteritis.
    J Rheumatol 2017 May 1. Epub 2017 May 1.
    From the Department of Internal Medicine, Unit for Systemic Diseases (UF07), and Department of Pathology, and Department of Internal Medicine, Unit for Autoimmune and Vascular Diseases (UF04), Saint-Louis University Hospital; ECSTRA Team, Epidemiology and Biostatistics, Sorbonne Paris Cité Research Center UMR 1153, INSERM, Paris; Department of Pathology, University Hospital Caen, Caen; Department of Biopathology, Léon-Bérard Cancer Center, Lyon, France. C. Le Pendu, MD, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital; V. Meignin, MD, Department of Pathology, Saint-Louis University Hospital; S. Gonzalez-Chiappe, MD, MPH, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital; A. Hij, MD, Department of Internal Medicine, Unit for Autoimmune and Vascular Diseases (UF04), Saint-Louis University Hospital; F. Galateau-Sallé, MD, PhD, Department of Pathology, University Hospital Caen, and Department of Biopathology, Léon-Bérard Cancer Center; A. Mahr, MD, MPH, PhD, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital, and ECSTRA Team, Epidemiology and Biostatistics, Sorbonne Paris Cité Research Center UMR 1153, INSERM. Address correspondence to Professor A. Mahr, Department of Internal Medicine, Hospital Saint-Louis, AP-HP, 1 avenue Claude-Vellefaux, 75475 Paris Cedex 10, France. E-mail: Accepted for publication March 17, 2017.
    Objective: We investigated the diagnostic value of inflammation limited to the adventitia (ILA), and isolated vasa vasorum or small-vessel vasculitis (VVV, SVV) in temporal artery biopsies (TAB) for giant cell arteritis (GCA).

    Methods: Two pathologists reviewed consecutive first TAB. Using the clinical diagnoses as the gold standard, positive predictive values (PPV) were calculated. Read More

    Healthcare Use and Direct Cost of Giant Cell Arteritis: A Population-based Study.
    J Rheumatol 2017 May 1. Epub 2017 May 1.
    From the Department of Internal Medicine, Division of Rheumatology; Department of Health Sciences Research, Division of Biomedical Statistics and Informatics; Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA. This study was made possible using the resources of the Rochester Epidemiology Project, which is supported by the US National Institute on Aging of the National Institutes of Health under Award Number R01-AG-034676 and the National Center for Advancing Translational Sciences through the Clinical and Translational Science Awards grant UL1-TR-000135. M.J. Koster, MD, Department of Internal Medicine, Division of Rheumatology, Mayo Clinic; S.J. Achenbach, MS, Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic; C.S. Crowson, MS, Department of Internal Medicine, Division of Rheumatology, and Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic; H. Maradit-Kremers, MD, MSc, Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic; E.L. Matteson, MD, MPH, Department of Internal Medicine, Division of Rheumatology, and Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic; K.J. Warrington, MD, Department of Internal Medicine, Division of Rheumatology, Mayo Clinic. Address correspondence to Dr. M.J. Koster, 200 First St. SW, Rochester, Minnesota 55905, USA. E-mail: Accepted for publication March 23, 2017.
    Objective: To determine the healthcare use and direct medical cost of giant cell arteritis (GCA) in a population-based cohort.

    Methods: A well-defined, retrospective population-based cohort of Olmsted County, Minnesota, USA, residents diagnosed with GCA from 1982-2009 was compared to a matched referent cohort from the same population. Standardized cost data (inflation-adjusted to 2014 US dollars) for 1987-2014 and outpatient use data for 1995-2014 were obtained. Read More

    Giant-Cell Arteritis: Do We Treat Patients with Large-Vessel Involvement Differently?
    Am J Med 2017 Apr 29. Epub 2017 Apr 29.
    Department of Internal Medicine, Caen University Hospital, University of Caen-Basse Normandie, France.
    Purpose: We aimed to describe the initial treatment that was used in a common hospital-based practice in patients with giant-cell arteritis with and without large-vessel involvement at diagnosis as well as the outcomes in both groups.

    Methods: This retrospective multi-center cohort included patients with giant-cell arteritis diagnosed between 2005 and 2015, all of whom had fluorodeoxyglucose (FDG) positron emission tomography combined with computed tomography (FDG-PET/CT) performed at giant-cell arteritis diagnosis and were followed up for ≥12 months. We compared the features, treatment, and outcomes of patients with large-vessel involvement demonstrated on FDG-PET/CT with those of patients with a negative PET/CT. Read More

    The use of ultrasound to assess giant cell arteritis: review of the current evidence and practical guide for the rheumatologist.
    Rheumatology (Oxford) 2017 Apr 27. Epub 2017 Apr 27.
    Rheumatology Department, NDORMS, Nuffield Orthopaedic Centre, University of Oxford, Oxford, UK.
    Colour duplex sonography (CDS) of temporal arteries and large vessels is an emerging diagnostic tool for GCA. CDS can detect wall oedema, known as a halo, throughout the length of the vessel and shows higher sensitivity compared with biopsy. Specificity reaches 100% in case of bilateral halos. Read More

    [Epidemiology and natural history of giant cell arteritis].
    Rev Med Interne 2017 Apr 27. Epub 2017 Apr 27.
    Unité de médecine interne-maladies systémiques, unité de médecine interne-maladies systémiques, CHU Saint-Louis, université Paris-Diderot, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France.
    Knowledge of the natural history and epidemiology of giant cell arteritis (GCA) is growing. With the recent conceptual change, GCA is no longer considered a disease with mandatory cranial symptoms but, rather, a larger disease spectrum also including idiopathic aortitis in people older than 50 and polymyalgia rheumatica with large-vessel involvement. The incidence peak between age 70 and 80 years, greater frequency in females and greater occurrence in Nordic countries are well-established epidemiological characteristics. Read More

    Head and neck giant cell arteritis: an autoimmune disease with many faces.
    Acta Otolaryngol 2017 Apr 25:1-6. Epub 2017 Apr 25.
    a Department of Otolaryngology - Head and Neck Surgery , Klinikum rechts der Isar, Technical University of Munich , Munich , Germany.
    Conclusion: A high rate of infrequent presentations of giant cell arteritis were seen in the ENT department and should be anticipated as a differential diagnosis in every older patient with odynophagia with high CRP values without cause in thorough ENT examination.

    Objective: To describe the clinical manifestation of head and neck giant cell arteritis and to derive a diagnostic pathway covering atypical cases.

    Method: Single-center, retrospective analysis of cases with GCA in the head and neck region (HN-GCA) (2002-2012) to describe the clinical presentation and to derive a diagnostic pathway covering manifestations presenting to an ENT department. Read More

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