7,685 results match your criteria Temporal Giant Cell Arteritis


Relapses and long-term remission in large vessel giant cell arteritis in northern Italy: Characteristics and predictors in a long-term follow-up study.

Semin Arthritis Rheum 2020 May 20;50(4):549-558. Epub 2020 May 20.

Rheumatology Unit, Department of Specialistic Medicine, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy; University of Modena and Reggio Emilia, Modena, Italy. Electronic address:

Objective: To evaluate characteristics and predictors of relapses and long-term remission in an Italian cohort of patients with large-vessel (LV) giant cell arteritis (GCA).

Methods: We evaluated 87 consecutive patients with LV-GCA followed up at the Rheumatology Unit of Reggio Emilia Hospital (Italy) for at least 2 years. Patients with relapses and long-term remission were compared to those without. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2020.04.004DOI Listing

Neurosarcoidosis Masquerading as Giant Cell Arteritis With Incidental Meningioma.

J Neuroophthalmol 2020 Apr 16. Epub 2020 Apr 16.

Wilmer Eye Institute (OMS, RF, ADH), Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Pathology (MAV), Division of Neuro-Ophthalmology (ADH, OMS); Division of Oculoplastics (RF), Johns Hopkins University School of Medicine, Baltimore, Maryland; and Department of Pathology, Mayo Clinic, Rochester, Minnesota.

We present a case of vision loss secondary to neurosarcoidosis, which initially presented with severe bilateral vision loss, temporal headaches, and elevated erythrocyte sedimentation rate, concerning for giant cell arteritis. However, temporal artery biopsy was negative. Initial neuroimaging features were misinterpreted to represent a meningioma that did not account for his clinical presentation. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000967DOI Listing

Colour Doppler ultrasound of temporal arteries for the diagnosis of giant cell arteritis: a multicentre deep learning study.

Clin Exp Rheumatol 2020 Mar-Apr;38 Suppl 124(2):120-125. Epub 2020 May 21.

Department of Internal Medicine, CHU Nantes, France.

Objectives: Giant cell arteritis (GCA) is the most common systemic vasculitis in adults. In recent years, colour Doppler ultrasound of the temporal arteries (CDU) has proven to be a powerful non-invasive diagnostic tool, but its place in the diagnosis of GCA remains to be defined. A limitation of the CDU is the inter-operator reproducibility. Read More

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Tocilizumab in giant cell arteritis: differences between the GiACTA trial and a multicentre series of patients from the clinical practice.

Clin Exp Rheumatol 2020 Mar-Apr;38 Suppl 124(2):112-119. Epub 2020 May 21.

Departments of Rheumatology, Internal Medicine and Pathology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Universidad de Cantabria, Santander, Spain.

Objectives: A potential point of concern among clinicians is whether results derived from the clinical trials can be reasonably applied or generalised to a definable group of patients seen in real world. It can be the case of the GiACTA study that is a phase III randomised controlled trial of tocilizumab (TCZ) in giant cell arteritis (GCA). To address this question, we compared the clinical features and the responses to TCZ from the GiACTA trial patients with those from a series of GCA seen in the daily clinical practice. Read More

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Retraction Note: Ultrasound versus temporal artery biopsy in patients with Giant cell arteritis: a prospective cohort study.

BMC Med Imaging 2020 May 21;20(1):54. Epub 2020 May 21.

Department of Cardiology, the first hospital of Lanzhou University, Lanzhou, 730000, China.

An amendment to this paper has been published and can be accessed via the original article. Read More

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http://dx.doi.org/10.1186/s12880-020-00454-7DOI Listing

[Pathogenesis of large vessel vasculitides].

Z Rheumatol 2020 May 19. Epub 2020 May 19.

Klinik für Rheumatologie und klinische Immunologie, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

Large vessel vasculitides comprise two distinct entities, giant cell arteritis (GCA) and Takayasu arteritis (TAK). GCA is the most common vasculitis in central Europe, becoming manifested at an age over 50 years. In contrast, the much rarer TAK affects almost exclusively young adults and mostly women. Read More

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http://dx.doi.org/10.1007/s00393-020-00809-zDOI Listing

[Long-term complications, monitoring and interventional treatment of large vessel vasculitis].

Z Rheumatol 2020 May 19. Epub 2020 May 19.

Klinik für Radiologie und Neuroradiologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Deutschland.

Giant cell arteritis (GCA) and Takayasu's arteritis (TAK) both belong to the group of large vessel vasculitides and require long-term drug treatment. Glucocorticoids (GC) are the first choice for the treatment of both diseases. For GCA immunosuppressants, such as tocilizumab or methotrexate should be considered in cases of treatment refractory and relapses or if there is a high risk for GC-related adverse events. Read More

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http://dx.doi.org/10.1007/s00393-020-00807-1DOI Listing

Giant Cell Arteritis with Aortic Involvement Leading to Cardio Vocal Syndrome (Ortner's Syndrome).

Arq Bras Cardiol 2020 Apr 18;114(4 Suppl 1):16-18. Epub 2020 May 18.

Departamento de Cardiologia, Hospital 13 de Maio, Sorriso, MT, Brasil.

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http://dx.doi.org/10.36660/abc.20180427DOI Listing

Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromes.

Blood Rev 2020 May 15:100707. Epub 2020 May 15.

Division of Hematology, University of British Columbia, Canada.

A subset of patients with severe COVID-19 develop profound inflammation and multi-organ dysfunction consistent with a "Cytokine Storm Syndrome" (CSS). In this review we compare the clinical features, diagnosis, and pathogenesis of COVID-CSS with other hematological CSS, namely secondary hemophagocytic lymphohistiocytosis (sHLH), idiopathic multicentric Castleman disease (iMCD), and CAR-T cell therapy associated Cytokine Release Syndrome (CRS). Novel therapeutics targeting cytokines or inhibiting cell signaling pathways have now become the mainstay of treatment in these CSS. Read More

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http://dx.doi.org/10.1016/j.blre.2020.100707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227559PMC

Giant cell arteritis: a pain in the neck.

Age Ageing 2020 May 18. Epub 2020 May 18.

Royal Berkshire NHS Foundation Trust, Reading, England.

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http://dx.doi.org/10.1093/ageing/afaa080DOI Listing

Involvement of the intracranial circulation in giant cell arteritis.

Can J Ophthalmol 2020 May 13. Epub 2020 May 13.

Division of Ophthalmology, Department of Surgery, McMaster University, Hamilton, Ont.; Division of Neurology, Department of Medicine, McMaster University, Hamilton, Ont.. Electronic address:

Objective: Giant cell arteritis (GCA) is the most common primary vasculitis affecting the elderly population. GCA preferentially involves the extracranial branches of the carotid artery; intracranial vasculitis is thought to be a rare occurrence. This study determined the prevalence of intracranial vasculitis in a large series of patients evaluated for GCA and describes the clinical presentation of such cases. Read More

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http://dx.doi.org/10.1016/j.jcjo.2020.04.002DOI Listing

Infections are associated with increased risk of giant cell arteritis - a population-based case-control study from Southern Sweden.

J Rheumatol 2020 May 15. Epub 2020 May 15.

From the Department of Clinical Sciences, Rheumatology, Lund University, Helsingborg, Sweden; Department of Clinical Sciences, Clinical Epidemiology Unit, Lund University, Lund, Sweden; Department of Clinical Sciences, Infection Medicine, Lund University, Lund, Sweden; Department of Clinical Sciences, Rheumatology, Lund University, Lund, Sweden; Department of Clinical Sciences Malmö, Rheumatology, Lund University, Malmö, Sweden; Department of Medicine, University of Cambridge, Cambridge, UK. This study was supported by grants from the Swedish Research Council (Vetenskapsrådet - 2019-01655). Address correspondence to Pavlos Stamatis, MD, Department of Internal Medicine, Rheumatology Section, SE-254 37 Helsingborg, Sweden.

Objective: To investigate the association of infections with the subsequent development of giant cell arteritis (GCA) in a large population-based cohort from a defined geographic area in Sweden.

Methods: Patients diagnosed with biopsy-confirmed GCA between 2000 and 2016 were identified through the database of the Department of Pathology in Skåne, the southernmost region of Sweden. For each GCA case, 10 controls matched for age, sex, and area of residence were randomly selected from the general population. Read More

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http://dx.doi.org/10.3899/jrheum.200211DOI Listing

Stevens Johnson Syndrome in a Patient with Giant Cell Arteritis During Short Term Tocilizumab Therapy.

Cureus 2020 Apr 13;12(4):e7662. Epub 2020 Apr 13.

Allergy and Immunology, Rutgers New Jersey Medical School, Newark, USA.

This case report represents a rare life-threatening hypersensitivity reaction of tocilizumab drug when it is used to treat giant cell arteritis. An elderly female with history of bilateral giant cell arteritis with anterior ischemic optic neuropathy of the right eye was started on tocilizumab after developing glucocorticoid-related complications. She received one month of the tocilizumab therapy along with the prednisone taper. Read More

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http://dx.doi.org/10.7759/cureus.7662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219013PMC

Acute visual loss without concurrent headaches due to ultrasound-negative, biopsy-proven giant cell arteritis.

Clin Med (Lond) 2020 Mar;20(Suppl 2):s58

The Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK.

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http://dx.doi.org/10.7861/clinmed.20-2-s58DOI Listing

Serious infections in people with polymyalgia rheumatica (PMR) or giant cell arteritis (GCA): a time-trend national US study.

Clin Rheumatol 2020 May 12. Epub 2020 May 12.

Department of Medicine, School of Medicine, Faculty Office Tower 805B, 510 20th Street S, Birmingham, AL, 35294-0022, USA.

Objective: To assess incidence, time-trends, and outcomes of serious infections in people with polymyalgia rheumatica (PMR) or giant cell arteritis (GCA).

Methods: We examined the 1998-2016 US National Inpatient Sample for serious infections in PMR or GCA, namely, opportunistic infections (OI), skin and soft tissue infections (SSTI), urinary tract infection (UTI), pneumonia, and sepsis/bacteremia. Multivariable-adjusted logistic regressions assessed association of the type of infection, demographics, comorbidity, and hospital characteristics with healthcare utilization and mortality. Read More

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http://dx.doi.org/10.1007/s10067-020-05129-wDOI Listing

[Treatment of giant cell arteritis: what is in the pipeline?]

Authors:
J U Holle F Moosig

Z Rheumatol 2020 May 12. Epub 2020 May 12.

Rheumazentrum Schleswig-Holstein Mitte, Kuhberg 5a-7, 24534, Neumünster, Deutschland.

Glucocorticoids (GC) represent the standard treatment in remission induction and maintenance in the treatment of giant cell arteritis (GCA). Additive immunosuppressants are currently only recommended in special situations, such as refractory or relapsing disease or in cases of glucocorticoid-induced side effects. Methotrexate has been the standard steroid-sparing agent for many years. Read More

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http://dx.doi.org/10.1007/s00393-020-00808-0DOI Listing

A rare presentation of kidney failure in a patient with giant cell arteritis: case report and review of literature.

Acta Clin Belg 2020 May 12:1-4. Epub 2020 May 12.

Department of Nephrology, Ghent University Hospital, Ghent, Belgium.

Although giant cell arteritis, also called temporal arteritis, is the most common primary vasculitis in the elderly, an association with AA amyloidosis has rarely been reported. AA amyloidosis is a disorder that results from the extracellular deposition of proteolytic cleavage products of serum amyloid A, which occurs in the setting of long-standing inflammation. We present a case of a patient with giant cell arteritis who developed a rapidly deteriorating kidney function, due to AA amyloidosis. Read More

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http://dx.doi.org/10.1080/17843286.2020.1763671DOI Listing

Practice Preferences: Temporal Artery Biopsy versus Doppler Ultrasound in the Work-Up of Giant Cell Arteritis.

Neuroophthalmology 2020 Jun 9;44(3):174-181. Epub 2019 Oct 9.

Department of Ophthalmology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.

To determine whether temporal artery biopsy (TABx) or Doppler ultrasound (US) of the temporal artery is the preferred confirmatory test for giant cell arteritis, an online survey of ophthalmologists and neurologists in North America, Europe and Israel was conducted in 2019; Canadian rheumatologists were also included. There were 406 survey participants with an estimated survey response rate of 18%. Ninety-four per cent of North American practitioners preferred TABx compared with 74% of their European counterparts. Read More

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http://dx.doi.org/10.1080/01658107.2019.1656752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202440PMC

Early variation of ultrasound halo sign with treatment and relation with clinical features in patients with giant cell arteritis.

Rheumatology (Oxford) 2020 May 11. Epub 2020 May 11.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford.

Objectives: To compare the ultrasound characteristics with clinical features, final diagnosis and outcome; and to evaluate the halo size following glucocorticoid treatment in patients with newly diagnosed GCA.

Methods: Patients with suspected GCA, recruited from an international cohort, had an ultrasound of temporal (TA) and axillary (AX) arteries performed within 7 days of commencing glucocorticoids. We compared differences in clinical features at disease presentation, after 2 weeks and after 6 months, according to the presence or absence of halo sign. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa196DOI Listing

Oral glucocorticoids and incidence of hypertension in people with chronic inflammatory diseases: a population-based cohort study.

CMAJ 2020 Mar;192(12):E295-E301

Leeds Institute of Biomedical and Clinical Sciences (Mebrahtu); Leeds Institute of Cardiovascular and Metabolic Medicine (Morgan), School of Medicine, University of Leeds; NIHR Biomedical Research Centre (Morgan, Stewart), Leeds Teaching Hospitals NHS Trust, Chapel Allerton Hospital; Leeds Institute of Health Sciences, (West, Pujades-Rodriguez), School of Medicine; Dean's office, Faculty of Medicine & Health (Stewart), University of Leeds, Leeds, UK

Background: Only a few population-based studies have examined the association between glucocorticoids and hypertension, with inconsistent results. We aimed to investigate the effect of oral glucocorticoids on incidence of hypertension in adults with chronic inflammatory diseases.

Methods: We analyzed electronic health records from 389 practices in England during 1998-2017 of adults diagnosed with any of 6 chronic inflammatory diseases but with no previous diagnosis of hypertension. Read More

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http://dx.doi.org/10.1503/cmaj.191012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101178PMC

Etiology, Diagnosis and Management of Aortitis.

Cardiovasc Intervent Radiol 2020 May 10. Epub 2020 May 10.

Department of Cardiovascular Radiology and Endovascular Interventions, All India Institute of Medical Sciences, New Delhi, 110029, India.

Aortitis includes conditions with infectious or non-infectious etiology, characterized by inflammatory changes in one or more layers in aortic wall. Age at onset, geographic predilections, distribution and pattern of involvement in aorta, its branches and pulmonary arteries, and systemic associations provide a clue to etiology. Clinical presentations are often non-specific. Read More

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http://dx.doi.org/10.1007/s00270-020-02486-6DOI Listing

Infectious keratitis as the presenting sign of giant cell arteritis.

Can J Ophthalmol 2020 May 5. Epub 2020 May 5.

Houston Methodist Hospital, Houston, TX; University of Texas MD Anderson Cancer Center, Houston, TX; Texas A and M College of Medicine, Bryan, TX; The University of Iowa Hospitals and Clinics, Iowa City, IA. Electronic address:

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http://dx.doi.org/10.1016/j.jcjo.2020.02.003DOI Listing

Diffuse large B cell lymphoma involving Meckel's cave masquerading as biopsy-negative giant cell arteritis: a case report.

J Med Case Rep 2020 May 10;14(1):57. Epub 2020 May 10.

Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.

Background: Given the absence of consensus diagnostic criteria for giant cell arteritis, clinicians may encounter difficulty with identification of new-onset headache in patients older than age 50 years presenting with visual changes and elevated inflammatory markers, particularly if temporal artery biopsies are performed and negative.

Case Presentation: We present a case of a 57-year-old white man with headache, diplopia, and jaw paresthesia initially diagnosed and managed as steroid-refractory biopsy-negative giant cell arteritis. Further investigation disclosed evidence of soft tissue infiltration into Meckel's (trigeminal) cave bilaterally. Read More

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http://dx.doi.org/10.1186/s13256-020-02379-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211338PMC

Endovascular Treatment of Intracerebral Giant Cell Arteritis.

Front Neurol 2020 16;11:287. Epub 2020 Apr 16.

Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.

Giant cell arteritis (GCA) is the most common primary systemic vasculitis predominantly affecting large and medium sized vessels. In rare cases, the vasculitis can affect the vessels of the brain. We describe four cases of GCA with involvement of the cerebral vessels causing stroke. Read More

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http://dx.doi.org/10.3389/fneur.2020.00287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177021PMC

Ophthalmic Emergencies for the Clinician.

Mayo Clin Proc 2020 May;95(5):1050-1058

Department of Ophthalmology, Mayo Clinic, Rochester, MN. Electronic address:

Primary care physicians are at the forefront of patient care and often are the first clinicians to triage and diagnose any eye-related complaints. They must be able to quickly identify vision-threatening pathologies, as delay in treatment of an ocular emergency can result in permanent vision loss. This concise review describes the definition, presentation, examination, and management of various ophthalmic emergencies including blunt ocular trauma, chemical ocular injury, orbital cellulitis, endophthalmitis, acute angle closure glaucoma, optic neuritis, giant cell arteritis, central retinal artery occlusion, retinal detachment, and homonymous hemianopia in a succinct manner. Read More

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http://dx.doi.org/10.1016/j.mayocp.2020.03.018DOI Listing

Reuma.pt/vasculitis - the Portuguese vasculitis registry.

Orphanet J Rare Dis 2020 May 5;15(1):110. Epub 2020 May 5.

Rheumatology Department, Hospital de Santa Maria - Centro Hospitalar Universitário Lisboa Norte, Centro Académico de Medicina de Lisboa, Lisbon, Portugal.

Background: The vasculitides are a group of rare diseases with different manifestations and outcomes. New therapeutic options have led to the need for long-term registries. The Rheumatic Diseases Portuguese Register, Reuma. Read More

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http://dx.doi.org/10.1186/s13023-020-01381-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201571PMC

Development of intracranial vasculitis in giant cell arteritis during tocilizumab treatment.

Authors:
Nazanin Naderi

Clin Exp Rheumatol 2020 Mar-Apr;38 Suppl 124(2):207-209. Epub 2020 May 1.

Department of Rheumatology, Danderyd Hospital, Stockholm, Sweden.

Giant cell arteritis (GCA), a systemic large-vessel vasculitis, is a disease that has been treated with glucocorticoids since 1950. Over the years, several disease-modifying anti-rheumatic drugs have been evaluated as steroid-sparing agents with disappointing results. Tocilizumab, an interleukin-6 inhibitor, has in recent years been approved for the treatment of GCA. Read More

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Follow-up vascular ultrasounds in patients with giant cell arteritis.

Clin Exp Rheumatol 2020 Mar-Apr;38 Suppl 124(2):107-111. Epub 2020 Apr 27.

Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, and Harvard Medical School, Boston, MA, USA.

Objectives: Literature describing follow-up vascular ultrasound (VUS) in giant cell arteritis (GCA) is limited. We report our experience with follow-up VUS obtained in clinical care of patients with GCA.

Methods: We retrospectively identified GCA patients with an abnormal initial VUS, defined as circumferential hypoechoic wall thickening ("halo sign"), or circumferential hyperechoic wall thickening without evidence of arteriosclerosis or arteritis, who subsequently underwent follow-up VUS during 2013-2018. Read More

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Skin necrosis in a patient with giant cell arteritis: a case report focusing on dermoscopic features.

Int J Dermatol 2020 May 2. Epub 2020 May 2.

Department of Dermatology, Hospital Universitario de Valme, Seville, Spain.

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http://dx.doi.org/10.1111/ijd.14912DOI Listing

Tocilizumab-induced sarcoidosis-like reaction in a patient with giant cell arteritis. Clinical implications of a paradoxical phenomenon.

Int J Dermatol 2020 May 2. Epub 2020 May 2.

Department of Dermatology-Venereology, Skåne University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.1111/ijd.14909DOI Listing

When the Temporal Artery Biopsy is Negative: A Case Series of Headache Attributed to Polymyalgia Rheumatica.

Neurologist 2020 May;25(3):70-72

Department of Neurology, Mayo Clinic, Scottsdale, AZ.

Introduction: Older adults presenting with a new or changed headache pattern in the setting of a diagnosis of polymyalgia rheumatica (PMR) are at risk for incident giant cell arteritis. However, the differential diagnosis of headache has not been evaluated in patients with a negative temporal artery biopsy (TAB). Headache has not been described as a symptom of PMR. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000262DOI Listing

Ocular manifestations in rheumatoid arthritis, connective tissue disease and vasculitis: a systematic review and meta-analysis.

J Rheumatol 2020 May 1. Epub 2020 May 1.

From the Schulich School of Medicine, University of Western Ontario, St. Joseph's Health Care, London, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada; Canadian Rheumatology Association Research studentship, University of Western Ontario. This funding was supported through the Canadian Rheumatology Association Roche summer studentship. There are no conflicts of interest. IRB was not necessary as this was a systematic literature review. Address correspondence to Dr. Janet Pope MD MPH FRCPC, Division of Rheumatology, St. Joseph's Health Care, 268 Grosvenor St. London ON N6A 4V2,

Objective: Rheumatoid Arthritis and other rheumatic diseases may present with ocular manifestations. The purpose of our work was to determine the prevalence and type of eye involvement in rheumatoid arthritis and other connective tissue diseases through a meta-analysis and literature review.

Methods: A systematic review of the literature was performed using Medline, Web of Science, and the Cochrane library from their inceptions until January 7, 2019. Read More

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http://dx.doi.org/10.3899/jrheum.190768DOI Listing

Training in and comfort with diagnosis and management of ophthalmic emergencies among emergency medicine physicians in the United States.

Eye (Lond) 2020 Apr 29. Epub 2020 Apr 29.

Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, 94305, USA.

Background/objectives: Patients with ophthalmic emergencies often present to emergency rooms. Emergency medicine (EM) physicians should feel comfortable encountering these conditions. We assessed EM physicians' comfort working up, diagnosing, and managing ophthalmic emergencies. Read More

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http://dx.doi.org/10.1038/s41433-020-0889-xDOI Listing

Treatment of giant-cell arteritis: from broad spectrum immunosuppressive agents to targeted therapies.

Rheumatology (Oxford) 2020 May;59(Supplement_3):iii17-iii27

Department of Autoimmune Diseases, Hospital Clínic, University of Barcelona. Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.

For decades, the treatment of GCA has relied on glucocorticoids. Work over the past two decades has supported a modest efficacy of MTX but no clear benefit from anti-TNF-based therapies. More recently, the therapeutic armamentarium for GCA has expanded. Read More

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http://dx.doi.org/10.1093/rheumatology/kez645DOI Listing

Diagnosis of giant cell arteritis.

Rheumatology (Oxford) 2020 May;59(Supplement_3):iii5-iii16

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

GCA is the most common form of primary systemic vasculitis affecting older people. It is considered a clinical emergency because it can lead to irreversible blindness in around 20% of untreated cases. High doses of glucocorticoids should be initiated promptly to prevent disease-related complications; however, glucocorticoids therapy usually results in significant toxicity. Read More

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http://dx.doi.org/10.1093/rheumatology/kez553DOI Listing

Window to the circulatory system: Ocular manifestations of cardiovascular diseases.

Eur J Ophthalmol 2020 Apr 27:1120672120914232. Epub 2020 Apr 27.

Department of Ophthalmology, Advanced Eye Center, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

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http://dx.doi.org/10.1177/1120672120914232DOI Listing

An atypical lower limb pain revealing a possible systemic venous vasculitis.

J Clin Ultrasound 2020 Apr 24. Epub 2020 Apr 24.

Département de médecine vasculaire, médecine interne et pneumologie, CHU de Brest, Hôpital La Cavale Blanche, Brest Cedex, France.

We describe a possible systemic vasculitis involving electively large veins. The patient presented with severe febrile lower limb pain. Diagnosis was made by color Doppler ultrasound (CDU) and confirmed by anatomopathological examination of the long saphenous vein, but not by examination of the temporal artery which was normal. Read More

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http://dx.doi.org/10.1002/jcu.22853DOI Listing

Translating IL-6 biology into effective treatments.

Nat Rev Rheumatol 2020 Apr 23. Epub 2020 Apr 23.

Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka, Japan.

In 1973, IL-6 was identified as a soluble factor that is secreted by T cells and is important for antibody production by B cells. Since its discovery more than 40 years ago, the IL-6 pathway has emerged as a pivotal pathway involved in immune regulation in health and dysregulation in many diseases. Targeting of the IL-6 pathway has led to innovative therapeutic approaches for various rheumatic diseases, such as rheumatoid arthritis, juvenile idiopathic arthritis, adult-onset Still's disease, giant cell arteritis and Takayasu arteritis, as well as other conditions such as Castleman disease and cytokine release syndrome. Read More

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http://dx.doi.org/10.1038/s41584-020-0419-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178926PMC

Giant Cell Arteritis Presenting as Bilateral Optic Perineuritis in an African Man.

J Neuroophthalmol 2020 Apr 21. Epub 2020 Apr 21.

Department of Ophthalmology and Medicine, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1097/WNO.0000000000000951DOI Listing

Red flags for a concomitant giant cell arteritis in patients with vertebrobasilar stroke: a cross-sectional study and systematic review.

Acta Neurol Belg 2020 Apr 22. Epub 2020 Apr 22.

Department of Neurology, University Hospital Würzburg, Josef-Schneider Street 11, 97080, Würzburg, Germany.

Giant cell arteritis (GCA) may affect the brain-supplying arteries, resulting in ischemic stroke, whereby the vertebrobasilar territory is most often involved. Since etiology is unknown in 25% of stroke patients and GCA is hardly considered as a cause, we examined in a pilot study, whether screening for GCA after vertebrobasilar stroke might unmask an otherwise missed disease. Consecutive patients with vertebrobasilar stroke were prospectively screened for GCA using erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), hemoglobin, and halo sign of the temporal and vertebral artery on ultrasound. Read More

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http://dx.doi.org/10.1007/s13760-020-01344-zDOI Listing

Temporal Artery Biopsy for Diagnosing Giant Cell Arteritis: A Ten-year Review.

J Ophthalmic Vis Res 2020 Apr-Jun;15(2):201-209. Epub 2020 Apr 6.

Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Purpose: To assess the use of temporal artery biopsy (TAB) in diagnosing giant cell arteritis (GCA) and to evaluate patients' clinical and laboratory characteristics.

Methods: We conducted a retrospective chart review of patients with suspected GCA who underwent TAB and had complete workup in a tertiary center in Iran between 2008 and 2017. The 2016 American College of Rheumatology (ACR) revised criteria for early diagnosis of GCA were used for each patient for inclusion in this study. Read More

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http://dx.doi.org/10.18502/jovr.v15i2.6738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151497PMC

Evaluation of deeper levels in initially negative temporal artery biopsies and likelihood of a positive result.

Ann Diagn Pathol 2020 Apr 8;46:151517. Epub 2020 Apr 8.

Department of Pathology, Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, OH 44195, USA. Electronic address:

Giant cell arteritis is a vasculitis that affects large- and medium-sized vessels in patients over the age of 50 years. The demonstration of granulomatous arteritis is the criterion standard to establish a definitive diagnosis. However, temporal arteritis is known to discontinuously involve the artery, and there is no standardization of the number of sections which should be examined in a length of sampled artery. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151517DOI Listing

Giant cell arteritis: more than a cranial disease.

Clin Exp Rheumatol 2020 Mar-Apr;38 Suppl 124(2):15-17. Epub 2020 Apr 5.

Division of Rheumatology, Hospital Universitario de la Princesa, IIS-Princesa, Madrid; and Cátedra UAM-ROCHE, Universidad Autónoma de Madrid (UAM), Madrid, Spain.

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3D T1-weighted black-blood magnetic resonance imaging for the diagnosis of giant cell arteritis.

Clin Exp Rheumatol 2020 Mar-Apr;38 Suppl 124(2):95-98. Epub 2020 Apr 4.

Université Paris Descartes, and Service de Médecine Interne, Centre de Référence Maladies Auto-Immunes et Systémiques Rares, Hôpital Cochin, AP-HP, Paris, France.

Objectives: Imaging techniques have an increasing place in the diagnosis of giant cell arteritis (GCA). Achieving a confident diagnosis of GCA is often challenging and temporal artery biopsy is still considered as the gold standard despite the delayed results. 3T-MRI with 2D sequences has been evaluated for the detection of mural inflammation in extracranial arteries to support the diagnosis of GCA. Read More

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Tropheryma Whipplei infection mimicking giant cell arteritis flare in a patient treated with interleukin-6 receptor blocker tocilizumab.

Clin Exp Rheumatol 2020 Mar-Apr;38 Suppl 124(2):245-246. Epub 2020 Apr 10.

Department of Internal Medicine, University Hospital, Besançon, France.

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Immunomodulatory role of Interleukin-33 in large vessel vasculitis.

Sci Rep 2020 Apr 14;10(1):6405. Epub 2020 Apr 14.

Sorbonne Universités, UPMC Univ Paris 06, INSERM, UMR S 959, Immunology-Immunopathology- Immunotherapy (I3), F-75005, Paris, France.

The mechanisms regulating inflammation in large vessels vasculitis (LVV) are poorly understood. Interleukin 33 (IL-33) has been shown to license innate and adaptive immunity by enhancing Th2 cytokines production. We aimed to examine the role of IL-33 in the immunomodulation of T cell activation in LVV. Read More

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http://dx.doi.org/10.1038/s41598-020-63042-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156501PMC
April 2020
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Temporal Arteritis and Vision Loss in Microscopic Polyangiitis: A Case Report and Literature Review.

Case Rep Nephrol 2020 26;2020:1426401. Epub 2020 Mar 26.

Penn Medicine Princeton Medical Center, Princeton Hypertension and Nephrology, 1 Plainsboro Rd, Plainsboro Township, NJ 08536, USA.

Microscopic polyangiitis (MPA) is an idiopathic autoimmune disease characterized by systemic vasculitis. While the lungs and kidneys are the major organs affected by MPA, it is known to involve multiple organ systems throughout the body. Temporal artery involvement is a very rare finding in MPA. Read More

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http://dx.doi.org/10.1155/2020/1426401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136809PMC

Temporal arteritis with focal pachymeningitis: a deceptive association.

Nagoya J Med Sci 2020 Feb;82(1):143-150

Department of Neurosurgery, Bantane Hospital, Fujita Health University, Nagoya, Japan.

Temporal arteritis is an immunological disorder mostly affecting the elderly population. This frequently occurs in association with other rheumatological diseases of the elderly. The symptoms of Temporal arteritis overlap with other symptoms of commonly occurring diseases in that population. Read More

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http://dx.doi.org/10.18999/nagjms.82.1.143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103863PMC
February 2020

Acute bilateral pseudogout of the temporomandibular joint.

Arthritis Rheumatol 2020 Apr 9. Epub 2020 Apr 9.

Department of Pathology, Good Samaritan Medical Center, Brockton, MA, United States.

An 84-year-old woman was transferred to a tertiary care center with 3 days of fevers, trismus, acute bilateral temporomandibular joint (TMJ) pain, and neck pain following a dental procedure. She had been treated empirically with broad-spectrum antibiotics and developed hypotension requiring vasopressors. CRP was >300 mg/L; ESR was 111 mm/h. Read More

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http://dx.doi.org/10.1002/art.41279DOI Listing