7,016 results match your criteria Temporal Giant Cell Arteritis


Myocarditis in Giant Cell Arteritis Diagnosed With Fluorine 18-Labeled Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography: Case Report and Review of the Literature.

J Clin Rheumatol 2018 Jun 21. Epub 2018 Jun 21.

Department of Medicine, Columbia University Medical Center-New York Presbyterian Hospital, New York, NY. Department of Rheumatology, Columbia University Medical Center-New York Presbyterian Hospital, New York, NY Department of Cardiology, Columbia University Medical Center-New York Presbyterian Hospital, New York, NY. Department of Pathology Columbia University Medical Center-New York Presbyterian HospitalNew York, NY. Department of Rheumatology, Columbia University Medical Center-New York Presbyterian Hospital, New York, NY.

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Giant Cell Arteritis.

Headache 2018 Jun;58(6):883-884

Department of Neurology, John R. Graham Headache Center, Brigham and Women's Faulkner Hospital, Harvard Medical School, Boston, MA, USA.

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Case report: giant cell arteritis in a patient with carotid atherosclerosis - a diagnostic dilemma.

Authors:
Beenish Fayyaz

J Community Hosp Intern Med Perspect 2018 12;8(3):134-137. Epub 2018 Jun 12.

Internal Medicine, Greater Baltimore Medical Center, Towson, MD, USA.

Carotid atherosclerosis and giant cell arteritis (GCA) are two distinct medical conditions with an overlapping clinical spectrum of vascular symptoms such as vision loss and ischemic stroke. This is because both diseases cause arterial ischemia with a predilection for carotid vasculature. In addition, high-vascular risk individuals who are diagnosed with GCA are usually elderly with age >55 years with high-vascular risk and thus can have underlying atherosclerosis. Read More

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Pain in optic neuropathies.

Neurol Sci 2018 Jun;39(Suppl 1):25-31

Neuro-ophthalmology and Ocular Electrophysiology Center, Department of Ophthalmology, Scientific Institute Capitanio Hospital, Istituto Auxologico Italiano Foundation, Via Mercalli, 28, 20122, Milan, Italy.

Pain occurs with optic neuropathies associated with inflammatory central nervous system diseases (MS and NMO), idiopathic intracranial hypertension and spontaneous hypotension, giant cell arteritis, immunomediated systemic diseases, compressive lesions, or infective disorders. Pain can precede the onset of visual loss in acute optic neuritis, it can be irradiated to the orbital region in giant cell arteritis and parasellar compressive optic neuropathies, or it may be located to the back of the eye with posterior scleritis. History of symptoms together with complete neuro-ophthalmological examination must guide the differential diagnosis and neuroimaging. Read More

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Predictors of positive F-FDG PET/CT-scan for large vessel vasculitis in patients with persistent polymyalgia rheumatica.

Semin Arthritis Rheum 2018 May 18. Epub 2018 May 18.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain; University of Cantabria, School of Medicine, Santander, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address:

Objective: Polymyalgia rheumatica (PMR) is often the presenting manifestation of giant cell arteritis (GCA). Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) scan often discloses the presence of large vessel vasculitis (LVV) in PMR patients. We aimed to identify predictive factors of a positive PET/CT scan for LVV in patients classified as having isolated PMR according to well-established criteria. Read More

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May 2018
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Radiographic study to assess the reliability of the Gillies approach for biopsy of the superficial temporal artery.

Br J Oral Maxillofac Surg 2018 Jun 9. Epub 2018 Jun 9.

Fiona Stanley Hospital, 11 Robin Warren Dr, Murdoch, WA, 6160. Electronic address:

Biopsy of the superficial temporal artery is often used in the diagnosis of giant cell arteritis, but at traditional sites there is a risk of injury to the facial nerve. Recently the Gillies incision has been suggested as an alternative means of access for the biopsy, but the anatomical basis of this has not been fully elucidated. We therefore undertook a radiographic review of 150 patients, and examining 300 vessels, to find out. Read More

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Pathologic Markers Determining Prognosis in Patients with Treated or Healing Giant Cell Arteritis.

Am J Ophthalmol 2018 Jun 8. Epub 2018 Jun 8.

Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA Blanton Eye Institute, Department of Ophthalmology, Houston Methodist Hospital, Houston, TX, USA Departments of Pathology and Laboratory Medicine and Ophthalmology, Weill Cornell Medical College, New York, NY, USA Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USA, Department of Pathology & Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Purpose: To provide quantitative evidence linking the Cluster of Differentiation-68 (CD68)+ macrophage-marker found on temporal artery biopsies (TABs) with disease prognosis.

Design: Retrospective, cross-sectional study METHODS: We examined 42 consecutive patients who had undergone unilateral TABs at a single hospital in 2015. Clinical data, laboratory data, and histopathologic features of TABs were recorded. Read More

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June 2018
2 Reads

The Association of Gout with Incident Giant Cell Arteritis in Older adults.

Joint Bone Spine 2018 Jun 7. Epub 2018 Jun 7.

Department of Medicine at School of Medicine.

Objectives: To assess whether gout is associated with a higher or lower risk of a new diagnosis of giant cell arteritis (GCA) in older adults, adjusting for known risk factors of GCA.

Methods: We used the 5% Medicare claims to conduct a multivariable Cox regression analyses to assess the association of gout with incident GCA in adults 65 years or older adjusting for age, gender, race (known risk factors for GCA) and Charlson-Romano comorbidity score, the use of medications for cardiovascular diseases (statins, beta-blockers, diuretics, ACE-inhibitors) and gout (allopurinol, febuxostat). Hazard ratios (HR) and 95% confidence intervals (CI) were calculated. Read More

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June 2018
2 Reads

Arterial lesions in giant cell arteritis: A longitudinal study.

Semin Arthritis Rheum 2018 May 9. Epub 2018 May 9.

Division of Rheumatology, St. Joseph's Healthcare, McMaster University, Hamilton, ON, Canada.

Objectives: To evaluate large-vessel (LV) abnormalities on serial imaging in patients with giant cell arteritis (GCA) and discern predictors of new lesions.

Methods: Clinical and imaging data from patients with GCA (including subjects diagnosed by LV imaging) enrolled in a prospective, multicenter, longitudinal study and/or a randomized clinical trial were included. New arterial lesions were defined as a lesion in a previously unaffected artery. Read More

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May 2018
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Incidence of cardiovascular events in polymyalgia rheumatica and giant cell arteritis amongst an Asian population: Propensity score matched cohort study.

Int J Rheum Dis 2018 Jun;21(6):1314-1321

Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Background: The hypothesis that patients with polymyalgia rheumatica (PMR) or giant cell arteritis (GCA) have a high risk for future cardiovascular diseases has not been adequately tested. The aim of this study is to evaluate this hypothesis in Japan, where the prevalence and severity of PMR and GCA are the lowest.

Methods: A propensity score matched cohort study was conducted at St. Read More

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June 2018
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Endovascular repair of inflammatory aortic aneuvrysm.

Tunis Med 2017 Dec;95(12):229-232

Introduction: While open repair was the gold standard treatment of atherosclerotic abdominal aortic aneurysms, its place in the treatment of inflammatory aortic aneurysms remains controversial.

Aim: To specify the place of endovascular repair in the treatment of inflammatory aneurysms.

Observation: We report 2 cases of inflammatory aortic aneurysms. Read More

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December 2017
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Should Antiviral/Anti-Varicella Zoster Virus Treatment Be Used in Patients With Giant Cell Arteritis?

J Neuroophthalmol 2018 Jun 5. Epub 2018 Jun 5.

Departments of Ophthalmology and Neurology (YJL), Stanford University Byers Eye Institute, Palo Alto, California; and Neurology and Ophthalmology (SK), University of Nebraska Medical Center, Omaha, Nebraska.

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June 2018
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Current and emerging diagnosis tools and therapeutics for giant cell arteritis.

Expert Rev Clin Immunol 2018 Jun 20:1-13. Epub 2018 Jun 20.

d Rheumatology Division , Hospital de La Princesa, IIS-Princesa, Universidad Autónoma de Madrid (UAM) , Madrid , Spain.

Introduction: Giant cell arteritis (GCA) is the most common large-vessel vasculitis in individuals older than 50 years from Western countries. The goal of the treatment is to achieve improvement of symptoms and clinical remission as well as decrease the risk of severe vascular complications. Areas covered: The review summarizes the main epidemiological and clinical features of GCA and discusses in depth both the classic and the new therapies used in the management of GCA. Read More

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June 2018
3 Reads

Co-Presentation of Giant Cell Arteritis and Granulomatosis with Polyangiitis: A Case Report and Review of Literature.

Am J Case Rep 2018 Jun 6;19:651-655. Epub 2018 Jun 6.

Department of Rheumatology, University of Missouri, Columbia, MO, USA.

BACKGROUND Systemic vasculitis can present with a multitude of symptoms involving multiple organ systems. Clinicians should avoid anchoring bias and be cognizant that different types of vasculitides can be present in the same patient and that the diagnosis of one should not preclude the subsequent diagnosis of another. CASE REPORT A 67-year-old woman was referred for evaluation of episodes of epistaxis and recurrent severe sinusitis. Read More

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June 2018
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Doppler ultrasonography of superficial temporal artery in a cohort of patients with strong clinical suspicion of giant cell arteritis.

Med Clin (Barc) 2018 Jun 2. Epub 2018 Jun 2.

Servei de Reumatologia, Hospital Moisès Broggi, Consorci Sanitari Integral (CSI), Sant Joan Despí (Barcelona), España; Servei de Reumatologia, Hospital General de L'Hospitalet, Consorci Sanitari Integral (CSI), L'Hospitalet (Barcelona), España. Electronic address:

Background And Objective: Giant cell arteritis (GCA) is the most frequent systemic vasculitis in adults. In recent years, the usefulness of temporal artery ultrasound (TAUS) as a diagnostic tool to assess the underlying inflammation of the vascular wall during the inflammatory process has been under clinical investigation.

Material And Methods: Observational and descriptive cohort study of 120 TAUS in 60 patients with clinical suspicions of GCA, according to the ACR (American College of Rheumatology) classification criteria. Read More

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June 2018
2 Reads

[Current patient care of giant cell arteritis in Rhineland-Palatinate].

Z Rheumatol 2018 Jun 4. Epub 2018 Jun 4.

Schwerpunkt Rheumatologie und klinische Immunologie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Langenbeckstraße 1, 55131, Mainz, Deutschland.

Background: Giant cell arteritis (GCA) is one of the most common forms of inflammatory vasculitis in older patients. Because of possible irreversible vision deterioration, a fastest possible diagnosis and therapy is of absolute importance. To date, there are still no reliable data to obtain an initial assessment of the outpatient health care situation of patients diagnosed with GCA in Rhineland-Palatinate. Read More

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June 2018
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Definitions and reliability assessment of elementary ultrasound lesions in giant cell arteritis: a study from the OMERACT Large Vessel Vasculitis Ultrasound Working Group.

RMD Open 2018 17;4(1):e000598. Epub 2018 May 17.

Medical Centre for Rheumatology, Immanuel Krankenhaus Berlin, Berlin, Germany.

Objectives: To define the elementary ultrasound (US) lesions in giant cell arteritis (GCA) and to evaluate the reliability of the assessment of US lesions according to these definitions in a web-based reliability exercise.

Methods: Potential definitions of normal and abnormal US findings of temporal and extracranial large arteries were retrieved by a systematic literature review. As a subsequent step, a structured Delphi exercise was conducted involving an expert panel of the Outcome Measures in Rheumatology (OMERACT) US Large Vessel Vasculitis Group to agree definitions of normal US appearance and key elementary US lesions of vasculitis of temporal and extracranial large arteries. Read More

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May 2018
3 Reads

Tongue and Scalp Necrosis: Simultaneous Initial Complications Revealing Giant Cell Arteritis.

J Rheumatol 2018 Jun;45(6):873-874

Department of Stomatology, Maxillofacial and Plastic Surgery, University Hospital, and UFR Medicine, University of Strasbourg, Strasbourg, France.

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June 2018
2 Reads

Inflammatory and infectious aortic diseases.

Cardiovasc Diagn Ther 2018 Apr;8(Suppl 1):S61-S70

Division of Vascular & Interventional Radiology, Mayo Clinic, Phoenix, AZ, USA.

Aortitis is aortic inflammation, which can be due to inflammatory or infectious diseases. Left undiagnosed, aortitis can lead to aneurysm formation and rupture, in addition to ischemic compromise of major organs. Infectious aortic diseases include mycotic aneurysm and graft infection; the most common inflammatory diseases are Takayasu's and giant cell arteritis. Read More

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April 2018
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Distribution patterns of 18F-fluorodeoxyglucose in large vessels of Takayasu's and giant cell arteritis using positron emission tomography.

Clin Exp Rheumatol 2018 Mar-Apr;36 Suppl 111(2):99-106. Epub 2018 May 18.

Rheumatology Unit, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, and Università di Modena e Reggio Emilia, Italy.

Objectives: To compare patterns of vascular involvement using 18F-fluorodeoxyglucose-positron emission tomography computed tomography (FDG PET/CT) in patients with giant cell arteritis (GCA) and Takayasu's arteritis (TAK).

Methods: A total of 130 consecutive 18F-FDG PET/CT scans performed during the disease course for evaluating disease activity in 15 GCA and 13 TAK patients were retrospectively examined by two nuclear physicians blinded to clinical data. Standardised uptake values (SUVmax) in 14 vascular districts including all the aortic segments and the main tributaries were measured. Read More

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May 2018
3 Reads

[«Man-in-the-barrel» syndrome: atypical manifestation of giant cell arteritis].

Rev Neurol 2018 Jun;66(11):373-376

Universidad de Antioquia, Medellin, Colombia.

Introduction: «Man-in-the-barrel» syndrome refers to diplegia of the upper extremities in which mobility of the head and lower limbs is preserved. Brachial plexitis that presents as «man-in-the-barrel» syndrome is an unusual manifestation of giant cell arteritis. We report a case of C5-C6 plexitis as part of the clinical features of a patient with giant cell arteritis. Read More

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June 2018
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Lower ocular pulse amplitude with dynamic contour tonometry is associated with biopsy-proven giant cell arteritis.

Can J Ophthalmol 2018 Jun 26;53(3):215-221. Epub 2017 Dec 26.

Harvard Medical School, Beth Israel Deaconess Hospital, Boston Department of Ophthalmology, Boston, MA.

Objectives: To determine the role of the ocular pulse amplitude (OPA) from Pascal dynamic contour tonometry in predicting the temporal artery biopsy (TABx) result in patients with suspected giant cell arteritis (GCA).

Design: Prospective validation study.

Participants: Adults aged 50 years or older who underwent TABx from March 2015 to April 2017. Read More

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June 2018
2 Reads

Simultaneous Presentation of Giant Cell Arteritis and Myelodysplastic Syndrome in an Elderly Japanese Man.

Intern Med 2018 May 18. Epub 2018 May 18.

Division of Hematology, St. Luke' s International Hospital, Japan.

An 81-year-old Japanese man presented with constitutional symptoms and anemia and was diagnosed with giant cell arteritis (GCA) and myelodysplastic syndrome (MDS) simultaneously. His symptoms and anemia improved promptly with steroids; however, the MDS rapidly progressed to overt leukemia. While MDS patients are at an increased risk of autoimmune diseases, an association with GCA has rarely been reported. Read More

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May 2018
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Paraneoplastic Large-vessel Vasculitis Associated with Myelodysplastic Syndrome.

Authors:
Hiroki Yabe

Intern Med 2018 May 18. Epub 2018 May 18.

Division of Rheumatology, First Department of Comprehensive Medicine, Jichi Medical University Saitama Medical Center, Japan.

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May 2018
1 Read

[Transient monocular blindness: Vascular causes and differential diagnoses].

Authors:
S Bidot D Biotti

J Fr Ophtalmol 2018 May;41(5):453-461

Service de neurologie B4, neurologie inflammatoire, neuro-ophtalmologie, bâtiment Pierre-Paul-Riquet, place du Dr-Baylac-TSA 40031, 31059 Toulouse cedex 9, France.

Transient monocular blindness is an acute episode of ischemic origin in which one eye has profound visual loss, followed by full recovery within one hour. Transient monocular blindness most often occurs in the setting of retinal ischemia secondary to carotid embolism, but other mechanisms have been reported, including thrombosis (most often in the setting of giant cell arteritis), hemodynamic disorders (secondary to severe carotid stenosis) or vasospasm. Transient monocular blindness is considered a transient ischemic attack originating in the carotid arteries and must benefit from the same management as transient ischemic attack involving the brain, in order to prevent a subsequent stroke. Read More

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May 2018
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Ustekinumab for refractory giant cell arteritis: A prospective 52-week trial.

Semin Arthritis Rheum 2018 Apr 22. Epub 2018 Apr 22.

Centre for Arthritis and Rheumatic Diseases, St Vincent's University Hospital, Dublin Academic Medical Centre, Elm Park, Dublin 4, Ireland.

Objectives: Giant cell arteritis (GCA) is the most common form of systemic vasculitis. Glucocorticoids are an effective treatment but have significant adverse events and relapses are common. Interleukins 12 (IL-12) and 23 (IL-23) stimulate T1 and T17 responses and are implicated in the pathogenesis of GCA. Read More

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April 2018
3 Reads

Primary Care Vasculitis: Polymyalgia Rheumatica and Giant Cell Arteritis.

Authors:
Mathilde H Pioro

Prim Care 2018 Jun;45(2):305-323

Department of Rheumatology, Orthopedic and Rheumatologic Institute, Cleveland Clinic, 9500 Euclid Avenue A50, Cleveland, OH 44195, USA; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 9500 Euclid Avenue A50, Cleveland, OH 44195, USA. Electronic address:

Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are related inflammatory diseases of adults aged 50 years or older. The diagnosis of PMR is based on morning stiffness, proximal shoulder and pelvic girdle pain, and functional impairment. GCA is characterized by headache, jaw claudication, and visual disturbances. Read More

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June 2018
2 Reads

species and orbital apex syndrome: Unsuspected co-infection.

Saudi J Ophthalmol 2018 Jan-Mar;32(1):86-89. Epub 2018 Feb 8.

Diagnostic Services of Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada.

species are thermally dimorphic fungi existing as yeast in tissue. We report an initially immunocompetent patient with orbital apex syndrome (OAS) whose presentation suggested giant cell arteritis. Subsequently, metastatic carcinoma was entertained as a cause of OAS until bronchoscopy yielded species. Read More

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February 2018
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Risk Associated with Cumulative Oral Glucocorticoid Use in Patients with Giant Cell Arteritis in Real-World Databases from the USA and UK.

Rheumatol Ther 2018 May 11. Epub 2018 May 11.

Genentech, Inc., South San Francisco, CA, USA.

Introduction: Treatment of giant cell arteritis (GCA) involves immediate initiation of high-dose glucocorticoid therapy with slow tapering of the dose over many months. Chronic exposure to glucocorticoids is associated with serious comorbidities. The objective of this analysis was to determine the glucocorticoid exposure and risk of glucocorticoid-related adverse events (AEs) in real-world patients with GCA. Read More

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May 2018
3 Reads

Pericarditis among giant cell arteritis patients: From myth to reality.

Clin Cardiol 2018 May 10;41(5):623-627. Epub 2018 May 10.

Department of Medicine B and Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.

Background: Giant cell arteritis (GCA) is an inflammatory disease of unknown etiology affecting adults age > 50 years. GCA (also known as temporal arteritis) is a vasculitis of large and medium-size vessels that involves the extracranial branches of the carotid artery. Common manifestations include constitutional symptoms, headache, jaw claudication, scalp tenderness, and vision loss. Read More

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May 2018
2 Reads

A case of giant cell arteritis mimicking vertebral dissection on contrast-enhanced magnetic resonance angiography.

Clin Exp Rheumatol 2018 Mar-Apr;36 Suppl 111(2):178-179. Epub 2018 Apr 19.

Division of Rheumatic Diseases, National Centre for Global Health and Medicine, Shinjuku, Tokyo, Japan.

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April 2018
2 Reads

Expression and Function of IL12/23 Related Cytokine Subunits (p35, p40, and p19) in Giant-Cell Arteritis Lesions: Contribution of p40 to Th1- and Th17-Mediated Inflammatory Pathways.

Front Immunol 2018 20;9:809. Epub 2018 Apr 20.

Vasculitis Research Unit, Department of Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS-CRB CELLEX), Barcelona, Spain.

Background: Giant-cell arteritis (GCA) is considered a T helper (Th)1- and Th17-mediated disease. Interleukin (IL)-12 is a heterodimeric cytokine (p35/p40) involved in Th1 differentiation. When combining with p19 subunit, p40 compose IL-23, a powerful pro-inflammatory cytokine that maintains Th17 response. Read More

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April 2018
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Platelet activation, as measured by plasma soluble glycoprotein VI, is not associated with disease activity or ischaemic events in giant cell arteritis.

Ann Rheum Dis 2018 May 5. Epub 2018 May 5.

Department of Rheumatology, Mater Misericordiae University Hospital, Dublin Academic Medical Centre, Dublin, Ireland.

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May 2018
3 Reads

Association between the functional PTPN22 G788A (R263Q) polymorphism and susceptibility to autoimmune diseases: A meta-analysis.

Cell Mol Biol (Noisy-le-grand) 2018 Apr 30;64(5):46-51. Epub 2018 Apr 30.

Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

This study explored whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) G788A (R263Q) polymorphism is associated with susceptibility to autoimmune diseases. A meta-analysis was conducted using 23 comparative studies with a total of 16,719 patients and 17,783 controls. The meta-analysis showed an association between the A allele of the PTPN22 G788A polymorphism and decreased risk of autoimmune diseases in all subjects (p < 0. Read More

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April 2018
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Positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging of macrophages in large vessel vasculitis: Current status and future prospects.

Autoimmun Rev 2018 May 3. Epub 2018 May 3.

Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

Macrophages are key players in the pathogenesis of large-vessel vasculitis (LVV) and may serve as a target for diagnostic imaging of LVV. The radiotracer, F-FDG has proven to be useful in the diagnosis of giant cell arteritis (GCA), a form of LVV. Although uptake of F-FDG is high in activated macrophages, it is not a specific radiotracer as its uptake is high in any proliferating cell and other activated immune cells resulting in high non-specific background radioactivity especially in aging and atherosclerotic vessels which dramatically lowers the diagnostic accuracy. Read More

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May 2018
1 Read

Cough and Giant Cell Arteritis.

QJM 2018 May 3. Epub 2018 May 3.

Department of General Medicine, Chiba University Hospital, Japan.

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May 2018
2 Reads

Bloodwork statistical prediction model for giant cell arteritis.

Authors:
Edsel Ing

Intern Med J 2018 05;48(5):607-608

Department of Ophthalmology, Michael Garron Hospital University of Toronto, Toronto, Ontario, Canada.

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May 2018
1 Read

Bilateral Giant Cell Arteritis Presenting as Bilateral Sudden Vision Loss.

Conn Med 2017 Apr;81(4):235-236

Giant cell arteritis (GCA) is the most common form of primary vasculitis and it mainly involves large to medium sized vessels. It is also referred to as temporal arteritis as it primarily affects the temporal artery. Ocular involvement frequently occurs in GCA; if not promptly diagnosed, it can cause devastating ocular complications including complete vision loss and permanent blindness. Read More

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April 2017
1 Read

Pseudolipomatosis of the Colon and Cecum Followed by Pneumatosis Intestinalis.

Intern Med 2018 Apr 27. Epub 2018 Apr 27.

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan.

A 74-year-old Japanese woman was diagnosed with pseudolipomatosis of the cecum and ascending colon. Colonoscopy was performed, which revealed the presence of slightly elevated white lesions, while a magnifying observation showed microbubbles within the mucosa. A month after colonoscopy, the patient was diagnosed with pneumatosis intestinalis. Read More

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April 2018
1 Read

Non-infective endocarditis: Expanding the phenotype of giant cell arteritis.

Joint Bone Spine 2018 Apr 27. Epub 2018 Apr 27.

Department of internal medicine, Croix Saint-Simon hospital, 75020 Paris, France.

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April 2018
2 Reads

CD3 immunohistochemistry is helpful in the diagnosis of giant cell arteritis.

Rheumatology (Oxford) 2018 Apr 25. Epub 2018 Apr 25.

Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Unità Operativa Complessa di Anatomia Patologica, Palermo, Italy.

Objective: To evaluate whether CD3 staining performed routinely on temporal artery biopsy specimens might improve the sensitivity of temporal artery biopsy in patients with biopsy-negative GCA.

Methods: Two hundred and seventy biopsies were considered for this study, stained with haematoxylin and eosin and with an anti-CD3 antibody.

Results: The addition of CD3 staining modified the sensibility and the specificity of the histologic examination in 89. Read More

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April 2018
2 Reads

Retrospective, Multicenter Comparison of the Clinical Presentation of Patients Presenting With Diplopia From Giant Cell Arteritis vs Other Causes.

J Neuroophthalmol 2018 Apr 24. Epub 2018 Apr 24.

Department of Ophthalmology (AGR, MP, GTL, KSS, MAT), Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Ophthalmology (IJ), University of Toronto, Toronto, Ontario, Canada; Department of Ophthalmology (GR), Cornell Medical Center, New York, New York; Department of Ophthalmology and Neurology (JJ-WC), Mayo Clinic, Rochester, New York; Department of Ophthalmology (RCS, MM), Wills Eye Hospital, Philadelphia, Pennsylvania; Department of Ophthalmology & Visual Sciences (CAS), University of British Columbia, Vancouver, British Columbia, Canada; Department of Ophthalmology (RF), Baylor College of Medicine, Houston, Texas; Department of Neurology (MWK), SUNY Upstate Medical University, Syracuse, New York; Department of Ophthalmology (CEF), University of Washington, Seattle, Washington; Department of Ophthalmology (ZRW), Flaum Eye Institute, University of Rochester Medical Center, Rochester, New York; Houston Methodist Ophthalmology Associates (AGL, SY, EP, MR), Houston, Texas; Department of Ophthalmology and Visual Neurosciences (CMM), University of Minnesota, Minneapolis, Minnesota; Department of Neurology and Ophthalmology (BO), Georgetown University, Washington DC; New England Eye Center (TRH), Tufts University, Boston, Massachusetts; Department of Ophthalmology and Neurology (GPVS, IG-B), Washington University, St. Louis, Missouri; and Department of Ophthalmology, University Hospital Virgen de la Victoria, Campus Teatinos, Málaga, Spain.

Background: Although giant cell arteritis (GCA) is a well-known cause of transient and permanent vision loss, diplopia as a presenting symptom of this condition is uncommon. We compared symptoms and signs of patients presenting with diplopia from GCA to those from other causes.

Methods: This was a multicenter, retrospective study comparing the clinical characteristics of patients presenting with diplopia from GCA with age-matched controls. Read More

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April 2018
3 Reads

Evaluating the utility of autoantibodies for disease activity and relapse in giant cell arteritis.

J Biol Regul Homeost Agents 2018 Mar-Apr;32(2):313-319

Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia.

In patients with giant cell arteritis (GCA), autoantibodies against cytoskeletal elements, cardiolipin, neutrophil cytoplasmic antigens, ferritin, endothelial and smooth muscle cells have been reported, however no updated reviews are available evaluating their clinical utility. Methodology of detection is important, especially for quantitative assays, e.g. Read More

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June 2018
1 Read

Temporal headache and jaw claudication may be the key for the diagnosis of giant cell arteritis.

Med Oral Patol Oral Cir Bucal 2018 May 1;23(3):e290-e294. Epub 2018 May 1.

Servicio Regional de Cirugía Oral y Maxilofacial, Hospital Universitario del Río Hortega, C/Dulzaina n 2, 47012 Valladolid, Spain,

Background: Temporal artery biopsy (TAB) is a surgical procedure with a low positive yield. The purpose of this study is to determine which variables are the most important in the giant cell arteritis (GCA) diagnosis. The objective of this evaluation is to improve the percentage of positive temporal artery biopsy and if possible, avoid the biopsy in some cases. Read More

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May 2018
1 Read

Tocilizumab for the treatment of giant cell arteritis.

Expert Rev Clin Immunol 2018 May 9;14(5):339-349. Epub 2018 May 9.

b Rheumatology Unit , Azienda Unità Sanitaria Locale IRCCS di Reggio Emilia, and Università di Modena e Reggio Emilia , Modena , Italy.

Introduction: Giant cell arteritis (GCA) is the most frequent type of vasculitis, occurring in people older than 50 years. So far, treatment has been limited to corticosteroids and methotrexate only. Areas covered: Interleukin-6 (IL-6) plays a role in the pathophysiology of GCA. Read More

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May 2018
3 Reads

Diagnostic positron emission tomography-computed tomography in clinically elusive giant cell arteritis.

Indian J Ophthalmol 2018 05;66(5):693-694

Department of Ophthalmology, Royal Free Hospitals NHS Foundation Trust, London, UK.

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May 2018
3 Reads

Prognosis and monitoring of giant cell arteritis and associated complications.

Expert Rev Clin Immunol 2018 May 26;14(5):379-388. Epub 2018 Apr 26.

b Division of Rheumatology , Mayo Clinic College of Medicine , Rochester , MN , USA.

Introduction: Giant cell arteritis (GCA) is the most common systemic vasculitis in people over the age of 50 years. Prospective imaging studies in GCA highlight the systemic nature of this vasculitis. Areas covered: This review summarizes literature using PubMed on complications of GCA and its treatment. Read More

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May 2018
3 Reads

Transient monocular blindness: Vascular causes and differential diagnoses.

Authors:
S Bidot D Biotti

J Fr Ophtalmol 2018 Apr 16;41(4):e129-e136. Epub 2018 Apr 16.

Centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France; Service de neurologie B4, neurologie inflammatoire, neuro-ophtalmologie, bâtiment Pierre-Paul-Riquet, place du Dr-Baylac, TSA 40031, 31059 Toulouse cedex 9, France.

Transient monocular blindness is an acute episode of ischemic origin in which one eye has profound visual loss, followed by full recovery within one hour. Transient monocular blindness most often occurs in the setting of retinal ischemia secondary to carotid embolism, but other mechanisms have been reported, including thrombosis (most often in the setting of giant cell arteritis), hemodynamic disorders (secondary to severe carotid stenosis), or vasospasm. Transient monocular blindness is considered a transient ischemic attack originating in the carotid arteries, and must be managed the same as transient ischemic attack involving the brain, in order to prevent a subsequent stroke. Read More

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April 2018
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Three days of high-dose glucocorticoid treatment attenuates large-vessel 18F-FDG uptake in large-vessel giant cell arteritis but with a limited impact on diagnostic accuracy.

Eur J Nucl Med Mol Imaging 2018 Jul 18;45(7):1119-1128. Epub 2018 Apr 18.

Department of Rheumatology, Aarhus University Hospital, Nørrebrogade 44, bygning 3, 8000, Århus C, Denmark.

Purpose: To evaluate the in-treatment diagnostic accuracy of FDG PET/CT in large-vessel giant cell arteritis (LV-GCA) by serial scans before and after a short course of high-dose glucocorticoid treatment.

Methods: Twenty-four glucocorticoid-naïve patients with new-onset PET/CT verified LV-GCA (pre-treatment baseline PET) were prospectively included. Excluded were patients with a previous history of GCA or polymyalgia rheumatica, LV-GCA-mimicking conditions and patients on immunosuppressive therapy. Read More

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July 2018
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Diagnosis and management of giant cell arteritis: an Asia-Pacific perspective.

Int J Rheum Dis 2018 Apr 17. Epub 2018 Apr 17.

Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia.

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April 2018
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