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    Varicella zoster virus-infected cerebrovascular cells produce a proinflammatory environment.
    Neurol Neuroimmunol Neuroinflamm 2017 Sep 13;4(5):e382. Epub 2017 Jul 13.
    Department of Neurology (D.J., M.A.N.), Department of Medicine (C.P.N., B.E.P.), and Department of Pediatrics (K.S.), University of Colorado School of Medicine, Aurora.
    Objective: To test whether varicella zoster virus (VZV) infection of human brain vascular cells and of lung fibroblasts directly increases proinflammatory cytokine levels, consistent with VZV as a causative agent in intracerebral VZV vasculopathy and giant-cell arteritis (GCA).

    Methods: Conditioned supernatant from mock- and VZV-infected human brain vascular adventitial fibroblasts (HBVAFs), human perineurial cells (HPNCs), human brain vascular smooth muscle cells (HBVSMCs), and human fetal lung fibroblasts (HFLs) were collected at 72 hours postinfection and analyzed for levels of 30 proinflammatory cytokines using the Meso Scale Discovery Multiplex ELISA platform.

    Results: Compared with mock infection, VZV infection led to significantly increased levels of the following: interleukin-8 (IL-8) in all cell lines examined; IL-6 in HBVAFs, HPNCs, and HFLs, with no change in HBVSMCs; and vascular endothelial growth factor A in HBVAFs, HBVSMCs, and HFLs, with a significant decrease in HPNCs. Read More

    Biological treatments in giant cell arteritis & Takayasu arteritis.
    Eur J Intern Med 2017 Nov 13. Epub 2017 Nov 13.
    Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
    Giant cell arteritis (GCA) and Takayasu arteritis (TAK) are the two main large vessel vasculitides. They share some similarities regarding their clinical, radiological and histological presentations but some pathogenic processes in GCA and TAK are activated differently, thus explaining their different sensitivity to biological therapies. The treatment of GCA and TAK essentially relies on glucocorticoids. Read More

    Positron Emission Tomography as an Imaging Biomarker in a Prospective, Longitudinal Cohort of Patients with Large Vessel Vasculitis.
    Arthritis Rheumatol 2017 Nov 16. Epub 2017 Nov 16.
    National Institutes of Health, Clinical Center, Radiology and Imaging Sciences, Bethesda, MD, USA.
    Objectives: To assess the clinical value of (18) F-flurodeoxyglucose (FDG) positron emission tomography (PET) in a prospective cohort of patients with large-vessel vasculitis (LVV) and disease comparators.

    Methods: Patients with Takayasu's arteritis (TAK) and giant cell arteritis (GCA) were studied, along with a comparator group consisting of patients with hyperlipidemia, diseases that mimic LVV, and healthy controls. Participants underwent clinical evaluation and FDG-PET imaging, and patients with LVV underwent serial imaging at six-month intervals. Read More

    [A Rare Differential Diagnosis of Chronic Cough].
    Dtsch Med Wochenschr 2017 Nov 16;142(23):1751-1755. Epub 2017 Nov 16.
    Klinik für Allgemeine Innere Medizin und Hausarztmedizin, Kantonsspital St. Gallen.
    History and admission findings We report on a 62-year-old male patient with dry cough for 3 months, constitutional symptoms and elevated inflammatory markers. Investigations Despite extensive diagnostics no infectious, malignant or rheumatologic disease could be found. Bronchoscopy with bronchoalveolar lavage showed lymphocytosis. Read More

    Neuroimaging diagnostic and monitoring approaches in ophthalmology.
    Curr Opin Neurol 2017 Nov 14. Epub 2017 Nov 14.
    aMassachusetts General Hospital bBrigham and Women's Hospital, Harvard Medical School cNeuro-ophthalmology Service, Massachusetts Eye & Ear, Harvard Medical School, Boston, Massachusetts, USA.
    Purpose Of Review: We review new applications of optical coherence tomography (OCT) technology in neuro-ophthalmology. We also describe new technologies for visualizing the extracranial vessels in the diagnosis of giant cell arteritis (GCA).

    Recent Findings: Newer OCT modalities are expanding the evaluation of the optic disc, and are being applied to a number of neurologic conditions such as demyelinating and neurodegenerative disease. Read More

    [18F]FDG positron emission tomography in patients presenting with suspicion of giant cell arteritis-lessons from a vasculitis clinic.
    Eur Heart J Cardiovasc Imaging 2017 Nov 8. Epub 2017 Nov 8.
    Department of Rheumatology, University Basel Hospital, Petersgraben 4, Basel 4031 Switzerland.
    Aims: The usefulness of [18F] fluorodeoxyglucose-positron emission tomography/computed tomography ([18F]FDG-PET/CT) for diagnosing giant cell arteritis (GCA) has been previously reported. Yet, the interpretation of PET scans is not clear-cut. The present study aimed at determining the best method to analyse PET/CT in a large, real-life cohort of patients presenting with suspicion of GCA. Read More

    Long-term glucocorticoid treatment in patients with polymyalgia rheumatica, giant cell arteritis, or both diseases: results from a national rheumatology database.
    Rheumatol Int 2017 Nov 9. Epub 2017 Nov 9.
    Epidemiology Unit, German Rheumatism Research Center, A Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.
    The objective of this study was to evaluate glucocorticoid (GC) use in patients with polymyalgia rheumatica (PMR), giant cell arteritis (GCA) or both diseases (PMR + GCA) under rheumatological care. Data from patients with PMR (n = 1420), GCA (n = 177) or PMR + GCA (n = 261) from the National Database of the German Collaborative Arthritis Centers were analyzed regarding GCs and related comorbidities (osteoporosis, diabetes and cardiovascular disease), stratified by disease duration (DD). Longitudinal data were analyzed for all patients with a DD ≤ 2 years at database entry (n = 1397). Read More

    Optical coherence tomographic angiography identifies peripapillary microvascular dilation and focal non-perfusion in giant cell arteritis.
    Br J Ophthalmol 2017 Nov 9. Epub 2017 Nov 9.
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
    Aims: We set out to determine the optical coherence tomographic angiography (OCT-A) characteristics of arteritic anterior ischaemic optic neuropathy (AAION) in the context of giant cell arteritis (GCA).

    Methods: This is an observational case series of four patients with AAION secondary to GCA, three with unilateral AAION and one with bilateral AAION. We reviewed the charts, fundus photography, visual fields, fluorescein angiography (FA) and OCT-A images for all patients to identify a unifying theme in a range of AAION clinical severity. Read More

    Case Report: Masquerading Large-vessel Giant Cell Arteritis.
    Optom Vis Sci 2017 Nov 9. Epub 2017 Nov 9.
    1Ophthalmology Service, University Hospitals and School of Medicine, Geneva, Switzerland 2Immunology and Allergy, University Hospitals and School of Medicine, Geneva, Switzerland
    Significance: Large-vessel giant cell arteritis (GCA) can be a diagnostic dilemma for the eye care provider because it may not involve the typical cranial arteries. When any of its potential ocular complications are diagnosed, it is important to consider this unusual form of GCA.

    Purpose: To report an unusual ophthalmic presentation of large-vessel GCA with sequential bilateral anterior ischemic optic neuropathy and branch retinal artery occlusion. Read More

    Decreased Immunity to Varicella Zoster Virus in Giant Cell Arteritis.
    Front Immunol 2017 24;8:1377. Epub 2017 Oct 24.
    Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Centre Groningen, Groningen, Netherlands.
    Introduction: Herpes zoster, which can have a major impact on quality of life, results from reactivation of a latent varicella zoster virus (VZV) infection. We hypothesized that giant cell arteritis (GCA) patients are at increased risk of herpes zoster because of treatment with high-dose glucocorticoids and advanced age. Aim of the study, therefore, was to determine cell-mediated and humoral immunity to VZV in patients with GCA, patients with closely related disease polymyalgia rheumatica (PMR; treated with lower doses of glucocorticoids) and healthy controls (HCs). Read More

    Clinical utility of anti-C1q antibody in primary and secondary vasculitic conditions.
    Int J Health Sci (Qassim) 2017 Nov-Dec;11(5):3-6
    Department of Clinical Immunology & Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India.
    Objective: Anti-C1q antibodies (Anti-C1q Ab) are seen in hypocomplementemic urticarial vasculitis syndrome (HUVS), infection-associated vasculitis such as hepatitis C virus-related vasculitis and in autoimmune diseases such as rheumatoid vasculitis, polyarteritis nodosa, giant cell arteritis, vascular Behcet's disease, and cryoglobulin associated vasculitis. Aim of this study is to evaluate the presence of Anti-C1q Ab in vasculitis and to determine if any difference exists between primary and secondary vasculitis in relation to this antibody.

    Patients And Methods: Consecutive patients with diagnosis of either a primary or secondary vasculitis were recruited. Read More

    Atherosclerosis as a potential pitfall in the diagnosis of giant cell arteritis.
    Rheumatology (Oxford) 2017 Nov 2. Epub 2017 Nov 2.
    Internal Medicine Department, Hospital Universitario La Paz, Madrid, Spain.
    Objectives: To explore whether the increase in the intima-media thickness (IMT) in arteriosclerotic disease correlates with the increase in the IMT in temporal arteries (TAs) and if that could mimic the US GCA halo sign.

    Methods: Consecutive patients ⩾50 years old with high vascular risk and without signs or symptoms of GCA were included. The carotid US IMT measurements were obtained using a standardized software radiofrequency-tracking technology. Read More

    Evaluation of damage in giant cell arteritis.
    Rheumatology (Oxford) 2017 Nov 3. Epub 2017 Nov 3.
    Division of Rheumatology and Department of Biostatistics and Clinical Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.
    Objectives: To evaluate damage and variables associated with damage in GCA.

    Methods: Patients with GCA enrolled in a prospective, multicentre, longitudinal study were included. Per-protocol assessments were made with the Vasculitis Damage Index and the Large-Vessel Vasculitis Index of Damage. Read More

    Reply to Bigler et al. (ar-17-1461).
    Arthritis Rheumatol 2017 Nov 6. Epub 2017 Nov 6.
    University of Alabama at Birmingham, Birmingham, AL.
    We thank Dr. Bigler and his colleagues for their interest in our article and sharing the results from their laboratory. The authors proposed evaluating a biologic mechanism linking Varicella Zoster Virus (VZV) to giant cell arteritis (GCA) through assessment of cross-reactive VZV-specific T cell immunity, hypothesizing that VZV reactive T-cells would be increased in GCA patients relative to controls. Read More

    Histopathological aspects of cardiovascular lesions in Kawasaki disease.
    Int J Rheum Dis 2017 Nov 3. Epub 2017 Nov 3.
    Department of Pathology, Ohashi Hospital, Toho University School of Medicine, Tokyo, Japan.
    Kawasaki disease (KD) is the commonest vasculitic syndrome. It affects medium-sized arteries, principally the coronary arteries. Histologically, coronary arteritis begins at 6 to 8 days after the onset of KD and the inflammation rapidly involves all layers of the artery. Read More

    Varicella Zoster Virus specific T cell responses in untreated Giant Cell Arteritis.
    Arthritis Rheumatol 2017 Oct 31. Epub 2017 Oct 31.
    Translational Immunology, Dep. of Biomedicine, University of Basel, Basel, Switzerland.
    Giant cell arteritis (GCA) is a large vessel vasculitis of unknown cause. Infections were long suspected as potential disease triggers, yet a disease causing pathogen has not been identified to date(1). Recently, several studies reported Varicella zoster virus (VZV) particles in artery biopsies(2). Read More

    Current and emerging therapies in large-vessel vasculitis.
    Rheumatology (Oxford) 2017 Oct 24. Epub 2017 Oct 24.
    Department of Rheumatology, Southend University Hospital & Anglia Ruskin University, Westcliff-on-sea, UK.
    GCA shares many clinical features with PMR and Takayasu arteritis. The current mainstay of therapy for all three conditions is glucocorticoid therapy. Given the chronic, relapsing nature of these conditions and the morbidity associated with glucocorticoid therapy, there is a need for better treatment options to induce and sustain remission with fewer adverse effects. Read More

    Refractory Giant Cell Arteritis Complicated by Vision Loss From Optic Atrophy and Maculopathy Associated With Pachymeningitis.
    J Neuroophthalmol 2017 Oct 20. Epub 2017 Oct 20.
    Departments of Rheumatology (JAU, IA, CMW), Ophthalmology (JW, YJL), and Pathology (GJB), Stanford University School of Medicine, Stanford, California; and Department of Rheumatology (US), Sequoia Hospital, Redwood City, California.
    Background: We describe a 75-year-old woman who experienced vision loss in her left eye due to biopsy-proven giant cell arteritis (GCA). She subsequently developed pachymeningitis causing refractory headaches and bilateral optic neuropathy and maculopathy.

    Methods: Case report with literature review. Read More

    Rare presentation of an old bug.
    BMJ Case Rep 2017 Oct 19;2017. Epub 2017 Oct 19.
    Department of Medicine, Division of Pulmonary and Critical Care, Mayo Clinic, Rochester, Minnesota, USA.
    We highlight a rare presentation of Legionella infection in a 77-year-old woman with a clinical diagnosis of giant cell arteritis 2 months prior to presentation. She was started on 60 mg prednisone that was tapered to 10 mg after 4 weeks following her diagnosis. She presented with a 1-month progressive dyspnoea in the absence of any other symptoms. Read More

    The proposed role of ultrasound in the management of giant cell arteritis in routine clinical practice.
    Rheumatology (Oxford) 2017 Oct 16. Epub 2017 Oct 16.
    Rheumatology Department, NDORMS, Nuffield Orthopaedic Centre, University of Oxford, Oxford, UK.
    Objective: To develop and explore a protocol for using colour duplex sonography (CDS) in the routine care of GCA.

    Methods: We tested CDS of temporal arteries and axillary arteries (AXs) on consecutive patients with suspected or established GCA, between July 2014 and September 2016.

    Results: We assessed 293 patients [age 72 (10), female/male 196/97], of whom 118 had clinically confirmed GCA. Read More

    Tempo(ral) was the heart of the matter.
    Surv Ophthalmol 2017 Oct 10. Epub 2017 Oct 10.
    Baylor College of Medicine, Houston, Texas, USA.
    A 71-year-old woman was admitted with fever, headache, and weight loss associated with elevated inflammatory markers. She developed acute bilateral ophthalmoplegia and asymmetrical ptosis, rapidly followed by anterior ischemic optic neuropathy. Although the first temporal artery biopsy was negative, contralateral temporal artery biopsy revealed features consistent with giant cell arteritis. Read More

    Diagnosis and management of polymyalgia rheumatica.
    Practitioner 2016 12;260(1799):13-6
    Polymyalgia rheumatica (PMR) is a common inflammatory condition of unknown aetiology with a prevalence of 1 in 133 in the over 50s, and a female to male ratio of 2:1. Symptoms develop over a matter of weeks; typically bilateral shoulder or pelvic girdle pain and stiffness, that is worse in the mornings. Associated symptoms include low-grade fever, malaise, fatigue, low mood, poor appetite, and weight loss. Read More

    Anterior Ischemic Optic Neuropathy Due to Calciphylaxis.
    J Neuroophthalmol 2017 Oct 6. Epub 2017 Oct 6.
    Departments of Ophthalmology (MSS, ØKJ), Pathology (EHS) and Dermatology (KMAE), Oslo University Hospital, Oslo, Norway.
    A 72-year-old woman experienced anterior ischemic optic neuropathy in her left eye. The funduscopic and fluorescein angiographic findings were strongly suggestive of giant cell arteritis. Temporal artery biopsy revealed extensive calcification in the vessel wall consistent with calciphylaxis. Read More

    Recognition of giant cell arteritis in patients with polymyalgia rheumatica who have a stroke: a cautionary tale.
    Intern Med J 2017 Oct;47(10):1199-1201
    West Australian Neuroscience Research Institute, QEII Medical Centre, Perth, Western Australia, Australia.
    An 82-year-old woman with polymyalgia rheumatica (PMR) on prednisone 7 mg daily was admitted to an acute stroke unit with a right homonymous hemianopia, a left posterior cerebral artery occlusion and occipital lobe infarct. She had raised inflammatory markers, did not have a temporal artery biopsy, and was discharged on the same dose of prednisone. After 21 months, off prednisone, her ophthalmologist, concerned about giant cell arteritis (GCA), restarted prednisone 40 mg daily, with rapid, profound visual improvement. Read More

    Teaching NeuroImages: Giant cell arteritis presenting with acute ischemic strokes due to diffuse intracranial stenoses.
    Neurology 2017 Oct 9;89(15):e190-e191. Epub 2017 Oct 9.
    From the Stroke Unit (O.K., A.S., G.M., E.S.) and Department of Pathology (V.N.P.), Metropolitan Hospital, Piraeus; Second Department of Neurology (A.S., G.T.), National & Kapodistiran University of Athens, School of Medicine, "Attikon" University, Greece; Department of Neurology (G.T.), The University of Tennessee Health Science Center, Memphis; and International Clinical Research Center (G.T.), Department of Neurology, St. Anne's University Hospital in Brno, Czech Republic.

    The role of colour doppler ultrasonography of facial and occipital arteries in patients with giant cell arteritis: A prospective study.
    Eur J Radiol 2017 Oct 16;95:9-12. Epub 2017 Jul 16.
    University Medical Centre Ljubljana, Department of Rheumatology, Vodnikova cesta 62, SI-1000 Ljubljana, Slovenia.
    Objective: Colour Doppler Sonography (CDS) in giant cell arteritis (GCA) allows the study of involvement of cranial arteries other than the temporal arteries, which are inconvenient to biopsy, such as the facial (FaA), and occipital (OcA) arteries. We aimed to estimate the frequency of the FaA, and OcA involvement in GCA; and to explore the clinical characteristics of these subgroups of patients.

    Methods: From 1 January 2014 to 31 December 2016 we prospectively performed a CDS of the FaA, and OcA in addition to the temporal (TA), and the extracranial supra-aortic arteries in all newly diagnosed patients suspected of having GCA. Read More

    PET-CT findings in patients with polymyalgia rheumatica without symptoms of cranial ischaemia.
    Dan Med J 2017 Oct;64(10)
    Introduction: Polymyalgia rheumatica (PMR) is an inflammatory disorder that affects the elderly. At present, evidence is limited regarding the usefulness of positron emission tomography-computed tomography (PET-CT) in the diagnosis of PMR. This study aimed to compare patient characteristics and symptoms with PET-CT findings in a Danish population of PMR patients without clinical symptoms of giant cell arteritis. Read More

    Incremental Costs in Giant Cell Arteritis.
    Arthritis Care Res (Hoboken) 2017 Oct 3. Epub 2017 Oct 3.
    INSERM, UMR 1027, F-31000, Toulouse, France.
    Objectives: To assess and compare direct costs between giant cell arteritis (GCA) patients and matched-controls and identify incremental cost drivers.

    Methods: We carried out a population-based, retrospective, cohort study using the French National Health Insurance System Database. Cost analysis was performed from the French health insurance perspective and took into account direct medical and non-medical costs (€, 2014). Read More

    Discrepancies between vascular and systemic inflammation in large vessel vasculitis: an important problem revisited.
    Rheumatology (Oxford) 2017 Sep 7. Epub 2017 Sep 7.
    Department of Internal Medicine, Division of Rheumatology, Marmara University School of Medicine, Istanbul, Turkey.
    A lack of absolute correlation between systemic inflammation parameters and ongoing vascular disease activity is an important problem in some patients with large vessel vasculitis, especially Takayasu arteritis (TAK). Systemic and vascular wall inflammation in TAK are obviously interrelated, but sometimes they may act independently. There are clear discrepancies between these two types of inflammation, including cytokine patterns and responses to treatment. Read More

    Increased expression of interleukin-22 in patients with giant cell arteritis.
    Rheumatology (Oxford) 2017 Sep 7. Epub 2017 Sep 7.
    Unit of Clinical Immunology, Allergy and Advanced Biotechnologies, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia.
    Objectives: GCA is characterized by arterial remodelling driven by inflammation. IL-22 is an attractive cytokine which acts at the crosstalk between immune and stromal cells. We hypothesized that IL-22 might be induced in GCA and might be involved in disease pathogenesis. Read More

    (18)F-FDG PET/CT in the follow-up of large-vessel vasculitis: A study of 37 consecutive patients.
    Semin Arthritis Rheum 2017 Aug 31. Epub 2017 Aug 31.
    Department of Nuclear Medicine, Hospital Universitario Marqués de Valdecilla, Molecular Imaging Group (IDIVAL), Santander, Spain; School of Medicine, University of Cantabria, Santander, Spain.
    Objective: (18)F-FDG PET/CT has proved to be of potential value for early diagnosis of large-vessel vasculitis (LVV), which frequently involves the aorta. However, its role in the follow-up of these patients has not been well established. Our aim was to evaluate the contribution of (18)F-FDG PET/CT in this clinical situation. Read More

    An update on the role of epigenetics in systemic vasculitis.
    Curr Opin Rheumatol 2017 Sep 27. Epub 2017 Sep 27.
    aDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA bDivision of Rheumatology, Faculty of Medicine, Marmara University, Istanbul, Turkey cCenter for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
    Purpose Of Review: The purpose of this review is to discuss recent observations of epigenetic changes related to the complex pathogenesis of systemic vasculitides and their contribution to the field.

    Recent Findings: There have been new observations of epigenetic changes in vasculitis and their potential role in disease pathogenesis in antineutrophil cytoplasmic antibody-associated vasculitis, giant-cell arteritis, Kawasaki disease, Behçet's disease, and IgA vasculitis. Some of this recent work has focused on the efficacy of using DNA methylation and miRNA expression as clinical biomarkers for disease activity and how DNA methylation and histone modifications interact to regulate disease-related gene expression. Read More

    Fluorine-18 Fluoro-2-Deoxyglucose Positron Emission Tomography Uptake in the Superficial Temporal and Vertebral Arteries in Biopsy Positive Giant Cell Arteritis.
    J Clin Rheumatol 2017 Sep 26. Epub 2017 Sep 26.
    From the *Departments of Rheumatology, Nuclear Medicine and Ophthalmology, Royal North Shore Hospital; †University of Sydney; ‡Institute of Rheumatology and Orthopaedics, Royal Prince Alfred Hospital; §Save Sight Institute; and ∥Concord Repatriation Hospital, Sydney, New South Wales, Australia.

    CYTOMEGALOVIRUS RETINITIS ASSOCIATED WITH OCCLUSIVE VASCULOPATHY IN AN ELDERLY, HUMAN IMMUNODEFICIENCY VIRUS-NEGATIVE MAN.
    Retin Cases Brief Rep 2017 Sep 20. Epub 2017 Sep 20.
    *Francis I. Proctor Foundation, Department of Ophthalmology, University of California, San Francisco, San Francisco, California; †Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California; ‡Department of Ophthalmology, California Pacific Medical Center, San Francisco, California; and §West Coast Retina Medical Group, San Francisco, California.
    Purpose: To present a case of cytomegalovirus (CMV) retinitis associated with occlusive vasculopathy presenting as sudden unilateral loss of vision in a human immunodeficiency virus-negative elderly man.

    Methods: Clinical case report and literature review.

    Results: An 84-year-old Chinese man with diabetes mellitus and primary open-angle glaucoma was seen in consultation by our uveitis service for evaluation of sudden vision loss in the right eye. Read More

    Positron Emission Tomography/Computerized Tomography in Newly Diagnosed Patients with Giant Cell Arteritis Who Are Taking Glucocorticoids.
    J Rheumatol 2017 Sep 15. Epub 2017 Sep 15.
    From the Division of Rheumatology, Department of Medicine, and the Department of Diagnostic Imaging, and the Division of Anatomic Pathology, Department of Pathology and Laboratory Medicine, and the Division of Vascular Surgery, Department of Surgery, Queen Elizabeth II Health Sciences Centre, Nova Scotia Health Authority; Dalhousie University, Halifax; Department of Radiology, Valley Regional Hospital, Kentville, Nova Scotia; Division of Rheumatology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. GE Healthcare Canada provided an unrestricted academic grant to support the imaging studies. A.H. Clifford, MD, Assistant Professor, Division of Rheumatology, University of Alberta; E.M. Murphy, MD, Assistant Professor of Medicine, Queen Elizabeth II Health Sciences Centre, Nova Scotia Health Authority, and Dalhousie University; S.C. Burrell, MD, Professor of Radiology, Queen Elizabeth II Health Sciences Centre, Nova Scotia Health Authority, and Dalhousie University; M.P. Bligh, MD, MASc, Department of Diagnostic Radiology, Queen Elizabeth II Health Sciences Centre, Nova Scotia Health Authority, and Dalhousie University; R.F. MacDougall, MD, FRCPC, Department of Radiology, Valley Regional Hospital; J.G. Heathcote, MB, PhD, FRCPC, Professor of Pathology and Ophthalmology and Visual Sciences, Queen Elizabeth II Health Sciences Centre, Nova Scotia Health Authority and Dalhousie University; M.C. Castonguay, MD, Assistant Professor, Departments of Pathology and Laboratory Medicine and Surgery, Queen Elizabeth II Health Sciences Centre, Nova Scotia Health Authority, and Dalhousie University; K. Matheson, MSc, Department of Medicine, Queen Elizabeth II Health Sciences Centre, Nova Scotia Health Authority, and Dalhousie University; M.S. Lee, MD, Assistant Professor, Division of Vascular Surgery, Department of Surgery, Queen Elizabeth II Health Sciences Centre, Nova Scotia Health Authority, and Dalhousie University, Halifax; J.G. Hanly, MD, Professor of Medicine and Pathology, Queen Elizabeth II Health Sciences Centre, Nova Scotia Health Authority, and Dalhousie University. Address correspondence to Dr. Alison H. Clifford, Division of Rheumatology, Department of Medicine, University of Alberta, 8-130K Clinical Sciences Building, University Campus, Edmonton, Alberta T6G 2G3, Canada. E-mail: Accepted for publication July 7, 2017.
    Objective: Large vessel uptake on positron emission tomography/computerized tomography (PET/CT) supports the diagnosis of giant cell arteritis (GCA). Its value, however, in patients without arteritis on temporal artery biopsy and in those receiving glucocorticoids remains unknown. We compared PET/CT results in GCA patients with positive (TAB+) and negative temporal artery biopsies (TAB-), and controls. Read More

    [Giant cell arteritis: Genetic and epigenetic aspects].
    Ter Arkh 2017;89(8):72-76
    I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.
    The paper describes clinical cases in 2 patients (brothers) with giant cell arteritis. It analyzes the genetic and epigenetic aspects of the disease. The data available in the Russian and foreign literature are given. Read More

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