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Otolaryngol Head Neck Surg 2019 Jan 1:194599818821863. Epub 2019 Jan 1.

5 Division of Hematology, Oncology, Blood and Marrow Transplant, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.

Cholesteatomas (CHSTs) are congenital or acquired lesions of the temporal bone that are associated with significant morbidity. We hypothesized that an oncolytic herpes simplex virus (oHSV) could preferentially eradicate primary human CHST cells in vitro and that this virus will replicate selectively and efficiently in CHST cells when compared with control cells. In this work, primary human CHST cells were cultured from surgically collected tissue. Read More

Head Neck Pathol 2018 Sep 1;12(3):419-429. Epub 2018 Aug 1.

Department of Oral & Maxillofacial Pathology, Naval Postgraduate Dental School, Naval Medical Professional Development Center, 8955 Wood Road, Bethesda, MD, 20889-5638, USA.

The European Academy of Otology and Neurotology in collaboration with the Japanese Otological Society (EAONO/JOS) recently produced a joint consensus document outlining the definitions, classification and staging of middle ear cholesteatoma. The goals were to provide terminologies in the description of cholesteatoma, classify cholesteatoma into distinct categories to facilitate the comparison of surgical outcomes and to provide a staging system that reflects the severity, difficulty of complete removal and restoration of normal function. Cholesteatoma is considered a benign, expanding and destructive epithelial lesion of the temporal bone that is the result of a multifactorial process. Read More

BMJ Case Rep 2018 May 12;2018. Epub 2018 May 12.

Skull Base Unit, Queen Elizabeth Hospital, Birmingham, UK.

Temporal bone osteoma is an unusual pathology which can occur by birth or can be acquired and mostly involves the tympanomastoid segment of the temporal bone. Osteomas arising from the otic capsule are extremely rare, and there has been only one other report of a lateral semicircular canal osteoma in the literature. We report a similar case of an acquired lateral canal osteoma which presented as a chronic postaural fistula in an ear previously operated for paediatric cholesteatoma. Read More

Int J Pediatr Otorhinolaryngol 2018 Mar 2;106:80-84. Epub 2018 Feb 2.

Ann & Robert H. Lurie Children's Hospital of Chicago, Division of Pediatric Otolaryngology-Head and Neck Surgery, Chicago, IL, United States; Northwestern University Feinberg School of Medicine, Department of Otolaryngology-Head and Neck Surgery, Chicago, IL, United States. Electronic address:

Introduction: The high incidence of chronic otitis media with effusion and Eustachian tube dysfunction in children with Down syndrome (DS) may predispose them to cholesteatoma formation. Establishing the diagnosis, choosing the appropriate operative intervention, and post-operative care can be challenging.

Objective: To describe management strategies for cholesteatoma diagnosis, surgical treatment, and post-operative management in children with Down syndrome. Read More

Eur Arch Otorhinolaryngol 2018 Mar 11;275(3):691-698. Epub 2018 Jan 11.

Department of Otolaryngology, Kamio Memorial Hospital, Tokyo, Japan.

Objective: For successful canal wall up tympanoplasty (CWUT) for the treatment of cholesteatoma, the restoration of stable middle ear aeration is also important; however, little is known about the dynamics of such aeration or the optimal surgical procedure. In this study, alternative additional surgical procedure was selected based on the grade of middle ear aeration during the second-stage operation.

Subjects And Methods: Patients included in this study underwent staged CWUT surgeries with mastoid cortex plasty (MCP) for well-aerated ears (grade 3) and bony mastoid obliteration (BMO) for poorly aerated ears (grade 2-0). Read More

Eur J Radiol Open 2017 14;4:144-146. Epub 2017 Nov 14.

Department of Radiodiagnosis DRPGMC, Tanda, Kangra, H.P., India.

Objective: To determine the use of multi-detector computed tomography (MDCT) in the diagnostic interpretation of superior semicircular canal dehiscence (SSCD) or thinning and its association with ear pathologies and to find whether it is an acquired condition and its association with increase in age.

Materials And Methods: study was performed in a tertiary care institute present in a village, following approval of the institutional ethical committee. Retrospective review of temporal bone CT examinations performed between September 2016 and March 2017 was done. Read More

Eur Arch Otorhinolaryngol 2017 Nov 21;274(11):3959-3964. Epub 2017 Aug 21.

Department of Radiology, Ondokuz Mayis University Faculty of Medicine, 55139, Atakum, Samsun, Turkey.

Cholesteatoma is a benign epithelial lesion affecting the middle ear and/or mastoid process, causing otorrhea and hearing loss. Here, we retrospectively evaluated the temporal multidetector computed tomography and audiological findings of acquired cholesteatoma in children. Forty-three patients younger than 18 years old with middle ear acquired cholesteatoma were evaluated with regard to their clinical symptoms, temporal multidetector computed tomography findings, and audiometry results. Read More

Eur Arch Otorhinolaryngol 2017 12 14;274(12):4251-4252. Epub 2017 Jun 14.

Department of Oral Surgery, Medical University of Gdansk, Smoluchowskiego 17, 80-214, Gdansk, Poland.

J Clin Diagn Res 2017 Mar 1;11(3):ED08-ED10. Epub 2017 Mar 1.

Specialist, Department of ENT, Deen Dayal Upadhyay Hospital, Delhi, India.

Cholesteatoma is a well demarcated, non-neoplastic, temporal bone cystic lesion with extensive keratinisation. Keratoma and epidermoid cyst are other possibly more accurate names suggested to describe the same. It can be classified as congenital or acquired. Read More

Auris Nasus Larynx 2018 Feb 6;45(1):45-50. Epub 2017 Mar 6.

Department of Otorhinolaryngology, Mitsui Memorial Hospital, Japan. Electronic address:

Objective: The Objective of this study was to assess the practicality of the cholesteatoma staging system proposed by the Japan Otological Society (JOS) for acquired middle ear cholesteatoma (the 2010 JOS staging system).

Methods: Between 2009 and 2010, 446 ears with retraction pocket cholesteatoma underwent primary surgery at 6 institutions in Japan. The extent of cholesteatoma was surgically confirmed, and classified into three stages. Read More

Clin Exp Otorhinolaryngol 2017 Sep 12;10(3):213-220. Epub 2017 Jan 12.

Department of Pathology, Fujita Health University School of Medicine, Toyoake, Japan.

Objectives: Cholesteatoma is a nonneoplastic destructive lesion of the temporal bone with debated pathogenesis and bone resorptive mechanism. Both molecular and cellular events chiefly master its activity. Continued research is necessary to clarify factors related to its aggressiveness. Read More

Auris Nasus Larynx 2017 Dec 29;44(6):766-770. Epub 2016 Dec 29.

Department of Otolaryngology, Jichi Medical University, Saitama Medical Center, Saitama-shi, Omiya-ku, Amanuma-cho 1-847, Saitama, Japan.

We report three patients with pars flaccida-type cholesteatoma (attic cholesteatoma) with closure of the entrance to the cholesteatoma at the time of surgery. These patients were diagnosed with attic cholesteatoma requiring surgery on the basis of abnormal findings of the pars flaccida, audiometry, and temporal bone computed tomography during the clinical course. Intraoperatively, cholesteatoma matrix and granulation tissue were observed behind the intact pars flaccida epithelium, which suggested that the entrance had apparently closed and the continuity with the cholesteatoma matrix disappeared after resolution of inflammation at the pars flaccida. Read More

Eur Arch Otorhinolaryngol 2017 May 16;274(5):2071-2078. Epub 2016 Dec 16.

Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.

Cholesteatoma is a destructive squamous epithelial lesion of the temporal bone which gradually expands and leads to serious complications by destruction of nearby bony structures. Erosion caused by bone resorption of the ossicular chain and bony labyrinth may result in hearing loss, vestibular dysfunction, facial paralysis, labyrinthine fistulae and intracranial complications. The exact underlying cellular and molecular mechanism of bone resorption in acquired cholesteatoma still remains unexplained. Read More

Acta Otolaryngol 2017 Feb 30;137(2):127-130. Epub 2016 Aug 30.

a Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine , University of Occupational and Environmental Health , Kitakyushu , Japan.

Conclusions: Osteoclasts are unlikely to be involved in bone resorption in middle ear cholesteatoma.

Objective: The authors searched for osteoclasts in undecalcified bone sections in patients with middle ear cholesteatoma to determine whether and to what extent these cells are involved in this disease.

Methods: Twelve patients, eight men and four women, aged 30-87 years, who underwent tympanomastoidectomy were enrolled. Read More

Clin Exp Otorhinolaryngol 2016 Dec 21;9(4):298-308. Epub 2016 Jul 21.

Department of Otolaryngology, Second Hospital, Fujita Health University School of Medicine, Nagoya, Japan.

Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorption mechanisms, and offer a future vision of this serious disease. We have reviewed different theories for pathogenesis of acquired cholesteatoma including the most relevant and updated ones with special emphasis on the mechanisms of bone resorption through Medline/PubMed research using the keywords 'aetiopathogenesis, bone resorption, acquired cholesteatoma, temporal bone, and cytokines. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2016 Feb;30(4):338-41

Cholesteatoma is a non-neoplastic, keratinizing lesion, characterized by the proliferation of epithelium with aberrant micro-architecture into the middle ear or mastoid cavity. The exact pathogenic molecular mechanisms behind the formation and propagation of cholesteatoma remain unclear. Without timely detection and intervention, cholesteatomas can become dangerous and result in numerous intracranial and extracranial complications. Read More

Laryngoscope 2017 03 16;127(3):698-701. Epub 2016 Jun 16.

Department of Otorhinolaryngology, Mayo Clinic School of Medicine, Rochester, Minnesota, U.S.A.

Objectives/hypothesis: To highlight the phenomenon of cholesteatoma arising from the vascular strip following tympanoplasty and tympanomastoidectomy.

Study Design: Multi-institutional retrospective chart review.

Methods: Consecutive adult and pediatric patients evaluated between 2000 and 2015 with acquired cholesteatoma arising from the skin of a prior vascular strip were identified. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2016 May;51(5):338-42

Department of Otorhinolaryngology, the First Hospital of China Medical University, Shenyang 110001, China.

Objective: To investigate the efficacy of operations of acquired middle ear cholesteatoma.

Methods: Retrospectively analyzed clinical data of 102 patients whom received tympanoplasty with CWU or CWD with mastoid obliteration in our hospital between January 2014 and December 2014. Patients were divided into different groups according to types of the cholesteatoma as well as the different surgical procedures. Read More

J Neurol Surg Rep 2016 Mar;77(1):e46-9

Organi di Senso Department, Sapienza University of Rome, Rome, Italy.

Petrous bone cholesteatomas (PBCs) are epidermoid cysts, which have developed in the petrous portion of the temporal bone and may be congenital or acquired. Cholesteatomas arising in this region have a tendency to invade bone and functional structures and the middle and posterior fossae reaching an extensive size. Traditionally, surgery of a giant PBC contemplates lateral transtemporal or middle fossa microscopic surgery; however, in recent years, endoscopic surgical techniques (primary or complementary endoscopic approach) are starting to receive a greater consensus for middle ear and mastoid surgeries. Read More

Eur Arch Otorhinolaryngol 2016 Sep 7;273(9):2533-40. Epub 2016 Jan 7.

Department of Otology and Skull Base Surgery, Gruppo Otologico, C/o Casa di Cura Piacenza Privata spa, Via Emmanueli, 42, Piacenza, Rome, 29121, Italy.

The objective of this study is to evaluate the outcomes of the modified Bondy's technique performed at our center and for limited epitympanic cholesteatomas and to debate the purported benefits of endoscopic surgery for the same indication. This is a retrospective study. 269 ears of 258 patients with a minimum of 5-year follow-up that were operated for limited epitympanic cholesteatoma using the modified Bondy's technique were included in the study. Read More

Auris Nasus Larynx 2016 Aug 9;43(4):387-94. Epub 2015 Oct 9.

Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Department of Otolaryngology, National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC. Electronic address:

Objective: This article presents a points-based prognostic prediction model for pediatric acquired cholesteatoma, incorporating the multidimensional factors that contribute to surgical failure.

Methods: This study included 132 ears with acquired cholesteatoma from 128 children (≤18 years) identified between 1982 and 2012. Each case was scored for the extent of the cholesteatoma, history of grommet insertion, age of the patient, ossicular destruction, and otorrhea. Read More

Cell Tissue Bank 2016 Jun 5;17(2):199-204. Epub 2015 Sep 5.

Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Wilrijkstraat 10, 2650, Edegem, Belgium.

Allograft tympano-ossicular systems (ATOS) have proven their use over many decades in tympanoplasty and reconstruction after resection of cholesteatoma. The transcranial bone plug technique has been used in the past 50 years to procure en bloc ATOS (tympanic membrane with malleus, incus and stapes attached). Recently, our group reported the feasibility of the endoscopic procurement technique. Read More

Eur Arch Otorhinolaryngol 2016 May 5;273(5):1155-60. Epub 2015 Jun 5.

Department of Otolaryngology Head and Neck Surgery, Niigata University Faculty of Medicine, Asahimachi-dori 1, Chuo-ku, Niigata, 951-8510, Japan.

This study examined the differences between congenital cholesteatoma (CC) and acquired cholesteatomas (AC) in children by comparing clinical features and treatment courses. This was a retrospective study which retrospectively evaluated 127 children with middle ear cholesteatomas using medical records from January 1999 to December 2012 in the Department of Otolaryngology, Niigata University Hospital. The study comprised 69 and 58 cases of CC and AC, respectively. Read More

Otol Neurotol 2015 Jun;36(5):776-81

*Department of Otolaryngology, Takanoko Hospital, Matsuyama, Ehime; and †Department of Otolaryngology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.

Objectives: We investigated the factors that may possibly cause primary acquired cholesteatoma.

Setting: University-affiliated hospital.

Subjects And Methods: In 20 adult patients with unilateral cholesteatoma, the sizes of the osseous eustachian tubes (ETs) and the extent of peritubal and mastoid cell development in healthy and diseased ears were examined using high-resolution cone-beam computed tomography. Read More

Int J Pediatr Otorhinolaryngol 2015 Mar 7;79(3):316-22. Epub 2015 Jan 7.

Otolaryngology Department, University Hospital of Modena, Via del Pozzo 71, 41100 Modena, Italy.

Objectives: The aim of the present study is to describe our experience in the management of tympanic cavity cholesteatoma in pediatric patients, treated with endoscopic exclusive transcanal approach.

Methods: A chart review of clinical data and videos from the operations of 54 pediatric patients, undergoing surgery between January 2007 and December 2013, was made. Patients presenting with cholesteatoma involving the tympanic cavity (mesotympanum, epitympanum, protympanum and/or hypotympanum), with no mastoid involvement, were included in the first group and underwent an exclusive transcanalar endoscopic approach (TEA). Read More

Eur Arch Otorhinolaryngol 2015 Dec 17;272(12):3601-9. Epub 2014 Sep 17.

Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei, 112, Taiwan, ROC.

The aim of this study was to review recent advances in the management of acquired cholesteatoma. All papers referring to acquired cholesteatoma management were identified in Medline via OVID (1948 to December 2013), PubMed (to December 2013), and Cochrane Library (to December 2013). A total of 86 papers were included in the review. Read More

Laryngoscope 2015 Jan 14;125(1):234-40. Epub 2014 Aug 14.

Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital; Department of Otolaryngology, National Yang-Ming University School of Medicine; Institute of Brain Science, National Yang-Ming University; Department of Otolaryngology, National Defense Medical Center, Taipei, Taiwan, R.O.C.; Department of Otolaryngology, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan, R.O.C.

Objective: To review recent biomolecular advances in etiopathogenesis of acquired cholesteatoma.

Data Sources: MEDLINE via OVID (to March 2014) and PubMed (to March 2014).

Review Methods: All articles referring to etiopathogenesis of acquired cholesteatoma were identified in the above databases, from which 89 articles were included in this review. Read More

Am J Otolaryngol 2014 Sep-Oct;35(5):589-93. Epub 2014 Jun 5.

Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, Japan.

Objective: This study aimed to analyze the clinical features of patients who underwent surgery for secondary acquired cholesteatoma (SAC).

Materials And Methods: The subjects were 30 patients who underwent surgery for SAC in 30 ears. We investigated the age distribution, sex, tympanic membrane (TM) findings, temporal bone pneumatization, morphology of TM epidermis invasion, extent of cholesteatoma invasion, ossicular erosion, surgical methods and surgical results. Read More

J Neuroradiol 2015 Jul 9;42(4):193-201. Epub 2014 Jul 9.

Faculty of Medicine, Louis-Pasteur University, 67000 Strasbourg, France; Laboratory of Biostatistics and Medical Informatics, Louis-Pasteur University, 67000 Strasbourg, France.

Background And Purpose: To compare diagnostic performances for cholesteatoma diagnosis of incremental MRI protocols including non-echo planar diffusion-weighted imaging (DWI) performed on 3T and 1.5T scanners.

Materials And Methods: Thirty-nine patients with suspected cholesteatoma underwent 3T and 1. Read More

Auris Nasus Larynx 2014 Oct 2;41(5):417-21. Epub 2014 Jun 2.

Department of Otolaryngology-Head and Neck surgery, Faculty of Medicine, Niigata University, Japan.

Objective: In general, cholesteatoma tends to recur more frequently in children than in adults. This has been suggested to be due to immature Eustachian tube function, underdeveloped mastoid air cells, and subsequent repetitive otitis media in children. This study was undertaken to determine the characteristics of acquired cholesteatoma in children by comparison with that in adults. Read More

Otol Neurotol 2014 Jul;35(6):961-5

Department of Otolaryngology Head and Neck Surgery, Niigata University Faculty of Medicine, Niigata, Japan.

Background: The pathogenesis of recurrent cholesteatoma can be roughly divided into residual lesions and re-retraction of the epithelium. To prevent both residual and re-retraction cholesteatoma, we performed canal wall down tympanoplasty with mastoid obliteration using the bone pate plate for canal wall reconstruction as a fundamental surgical treatment for patients with acquired cholesteatoma. We attempted to achieve the complete extirpation of cholesteatoma in the wide surgical field made by the canal wall down procedure and simultaneously prevent recurrent retraction cholesteatoma and regain the physiologic canal wall, in which patients can have a "maintenance-free ear. Read More

Int J Pediatr Otorhinolaryngol 2014 Jun 15;78(6):918-22. Epub 2014 Mar 15.

Department of Clinical and Experimental Medicine, Unit of Audiology and Pediatric Otorhinolaryngology, University of Parma, Italy.

Objectives: To review an institutional experience with the surgical management of middle ear cholesteatoma in children with cleft palate.

Materials And Methods: We analyzed retrospectively 18 children diagnosed with cleft palate who underwent surgery for acquired middle ear cholesteatoma between 2000 and 2007. The following data were recorded: age, sex, history of ventilation tube insertion, status of the contralateral ear, cholesteatoma location and extension, and surgical technique involved. Read More

J Med Liban 2014 Jan-Mar;62(1):7-13

Aim Of The Study: To define the predictive factors of recurrence of the pediatric acquired cholesteatoma in order to improve the long-term results, to restore a good hearing function and to prevent the complications.

Patients And Methods: A retrospective study concerning all cases of pediatric acquired cholesteatoma, treated during the period 1997-2008 in our center, and followed up for at least one year. A description of the parameters concerning the patients, disease and treatment as well as a univariate analysis were undertaken in order to determine the recurrence predictors. Read More

Ear Nose Throat J 2014 Feb;93(2):E17-9

Department of Otolaryngology-Head and Neck Surgery, Northwestern Memorial Hospital, Chicago, IL, USA.

Acquired cholesteatomas typically arise in the middle ear and mastoid cavities; they rarely present elsewhere. We describe a case of acquired cholesteatoma that presented as a large mass of the pars squamosa of the temporal bone in a 16-year-old girl. The mass was surgically removed without complication. Read More

Mediators Inflamm 2013 7;2013:651207. Epub 2013 Nov 7.

Department of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China.

Cholesteatoma is a benign keratinizing and hyper proliferative squamous epithelial lesion of the temporal bone. Epidermal growth factor (EGF) is one of the most important cytokines which has been shown to play a critical role in cholesteatoma. In this investigation, we studied the effects of EGF on the proliferation of keratinocytes and EGF-mediated signaling pathways underlying the pathogenesis of cholesteatoma. Read More

Clin Med Insights Ear Nose Throat 2013 23;6:21-8. Epub 2013 Jul 23.

Department of Otorhinolaryngology, Faculty of Medicine, Minia University, Egypy.

Background: Acquired cholesteatomas are commonly seen in patients less than 30 years. There is a typical history of recurrent middle ear infections with tympanic membrane perforation. The diagnosis of cholesteatoma is usually made on otologic examination. Read More

Am J Otolaryngol 2013 Nov-Dec;34(6):652-7. Epub 2013 Aug 5.

Department of ENT, Cizre State Hospital, Sirnak, Turkey.

Objective: The aim of our study was to investigate the relationship between the destruction of temporal bone structures, ossicular chain destruction, dissemination of cholesteatoma and the expressions of bone morphogenetic proteins (BMPs), BMP-2, BMP-4 and BMP-6 in patients with acquired cholesteatoma.

Material And Methods: This study was performed in a total of 80 patients with cholesteatoma and without cholesteatoma who had undergone surgery due to chronic otitis media. The patients were grouped as the study and the control groups. Read More

Curr Opin Otolaryngol Head Neck Surg 2013 Oct;21(5):440-5

Department of Otolaryngology/Head and Neck Surgery, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, Arkansas 72205, USA.

Purpose Of Review: This review focuses on the most recent literature pertaining to pediatric acquired cholesteatoma and aims to integrate findings into a comprehensive management approach.

Recent Findings: Pediatric acquired cholesteatoma has been shown to differ from the adult variety secondary to anatomy and physiologic factors. Whereas the goals of therapeutic management are ultimately similar in adult and pediatric patients, special considerations must be taken into account when deciding on a treatment plan for a child. Read More

J Laryngol Otol 2013 Jun 9;127(6):542-9. Epub 2013 May 9.

Department of Otorhinolaryngology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.

Background: Cholesteatoma is considered a benign, gradually expanding and destructive epithelial lesion of the temporal bone. The pathogenesis of different classifications of cholesteatoma is marked by similar underlying cellular and molecular processes. Stepwise explanations of the histopathogenesis have been described previously. Read More

Eur Arch Otorhinolaryngol 2014 May 16;271(5):933-7. Epub 2013 Apr 16.

Department of Ear, Nose and Throat, National Hospital Abuja, Plot 132, Central Area Garki (Phase 2), Abuja, FCT 900001, Nigeria,

The incidence of cholesteatoma among Nigerians is not well documented, as is the outcome of surgical treatment. A descriptive analysis of prospectively collected data of cases of cholesteatoma managed with tympanomastoidectomy at National Hospital Abuja between September 2005 and April 2012 is presented. Cases were analyzed for age, sex, type of cholesteatoma, intra-operative findings, and post-operative outcome after 6 months of follow up. Read More

Audiol Neurootol 2012 28;17(6):386-94. Epub 2012 Aug 28.

Department of Otorhinolaryngology - Head and Neck Surgery, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.

Objective: Following cholesteatoma surgery, effective long-term hearing preservation in children is difficult and is not typically expected. Hence, long-term data on hearing outcomes are lacking. The aim of this study was to analyze long-term hearing outcomes in children following cholesteatoma surgery. Read More

Radiographics 2012 Jul-Aug;32(4):1197-213

Departments of Radiology and ENT Surgery, Hospital Universitari í Politècnic La Fé de Valencia, Bulevar Sur s/n, 46026 Valencia, Spain.

Middle ear cholesteatoma is a common inflammatory disease that requires surgery due to potentially serious intracranial complications. Diagnosis of cholesteatoma is mainly clinical, with computed tomography (CT) used to evaluate disease extension before surgery. Certain patterns of bone erosion are specific, but CT attenuation does not allow differentiation from other inflammatory middle ear diseases. Read More

Kulak Burun Bogaz Ihtis Derg 2012 Jul-Aug;22(4):207-13

Department of Otolaryngology, Tepecik Training and Research Hospital, İzmir, Turkey.

Objectives: In this study, we aimed to evaluate the anatomical and functional results of open cavity tympanomastoidectomy due to chronic otitis media with cholesteatoma.

Patients And Methods: Between January 2003 and October 2009, 166 patients who underwent open cavity tympanomastoidectomy due to chronic otitis media with cholesteatoma in our clinic were retrospectively analyzed. Seventy-two ears of 69 patients (40 males, 29 females; mean age 36. Read More

Braz J Otorhinolaryngol 2012 Jun;78(3):116-21

Medical Faculty of ABC.

Unlabelled: Acquired middle ear cholesteatoma is a benign keratinizing hyperproliferative squamous epithelial lesion that may result in the destruction of the bone structures surrounding the temporal bone. Recent studies show that variations in cellular production of matrix metalloproteinases (MMPs) and their specific inhibitors (TIMPs) contribute to the pathophysiology of cholesteatoma.

Objective: This study aims to analyze the use of RNA amplification tests to evaluate the expression of MMP and TIMP isoforms in cholesteatomas and their correlation with disease severity. Read More

Vojnosanit Pregl 2012 Apr;69(4):363-6

Institute for Otorhinolaringology and Maxillofacial Surgery, Faculty of Medicine, University of Belgrade, Serbia.

Introduction: Etiopathogenetically, there are two types of chollesteatomas: congenital, and acquired. Numerous theories in the literature try to explain the nature of the disease, however, the question about cholesteatomas remain still unanswered. The aim of the study was to present a case of external ear canal cholesteatoma (EEC) developed following microsurgery (ventilation tube insertion and mastoidectomy), as well as to point ant possible mechanisms if its development. Read More

Ear Nose Throat J 2012 May;91(5):188

House Ear Clinic, Los Angeles, USA.

Otol Neurotol 2012 Apr;33(3):387-92

Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York 10065, USA.

Objective: To investigate and analyze the relationship between individual ossicular erosion and air-bone gap (ABG) among patients with cholesteatoma.

Study Design: Retrospective case review.

Setting: Tertiary referral center. Read More

Otol Neurotol 2012 Jan;33(1):42-7

Department of Otolaryngology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.

Hypothesis: That acquired cholesteatoma of the human middle ear and mastoid process can be caused by migration of squamous epithelium from the tympanic membrane.

Objective: To provide histologic evidence in humans of the potential for medial epithelial migration toward the middle ear.

Background: The origin of cholesteatomas of the middle ear complex of humans is still not clearly understood. Read More

AJNR Am J Neuroradiol 2011 Nov-Dec;32(10):1915-8. Epub 2011 Jul 21.

Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background And Purpose: Previous reports have shown that DWI is useful in detecting cholesteatoma. SS-EPI is the most widely used DWI technique. However, SS-EPI may have susceptibility artifacts due to field inhomogeneity in the imaging of the temporal bone region. Read More

Otol Neurotol 2011 Aug;32(6):992-5

Department of Otolaryngology, Royal Children's Hospital, Brisbane, Australia.

Objective: Reclassification of acquired cholesteatoma into the commonly observed presentations of this condition to provide a simple and clear grouping that indicates the pathology, management, and outcomes of the group cases.

Patients: Virgin acquired cholesteatoma cases from a single center managed from 1986 to 2008 (515 cases).

Interventions: Cases were managed by transcanal (20%) or intact canal wall techniques. Read More